MTA Cooperative Group. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD. Archives of general psychiatry. 1999;56:1073-86. PMID 10591283

One-paragraph summary

579 children aged 7–9.9 years; 14 months; medication management and combined care produced the largest core-symptom gains. (MTA Cooperative Group 1999, PMID 10591283).

Key findings

• 579 children aged 7–9.9 years; 14 months; medication management and combined care produced the largest core-symptom gains.

Limitations

• The trial enrolled combined-type children; later naturalistic convergence prevents simple long-term randomized attribution.

Why it matters

It remains the pivotal direct comparison of carefully managed medication, intensive behavioral care, their combination and community care.

Cited by wiki pages

• Childhood and adolescent ADHD
• Pharmacologic treatment
• Psychosocial and digital treatment