Demontis et al. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature genetics. 2019;51:63-75. PMID 30478444

One-paragraph summary

20,183 cases and 35,191 controls; 12 independent genome-wide significant loci; enrichment near brain-expressed regulatory marks. (Demontis 2019, PMID 30478444).

Key findings

• 20,183 cases and 35,191 controls; 12 independent genome-wide significant loci; enrichment near brain-expressed regulatory marks.

Limitations

• Case-control composition and ancestry constrain transportability; individual variants have very small effects.

Why it matters

It converted common-variant ADHD genetics from sub-threshold candidate signals to reproducible genome-wide discovery.

Cited by wiki pages

• Genetics and neurobiology
• Biomarkers
• Attention-deficit/hyperactivity disorder — overview