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Post-traumatic stress disorder — master index

Last curated: 2026-10-23 (Grok sweep; independent audit pending) · 9 curated + 13 draft wiki pages · 434 unique PMIDs (422 previously catalogued + 12 this sweep; flagged integrity records remain documentation only) · 6 landmark notes · 11 guideline records · 22 cited NCT records re-fetched live on 2026-10-23 · 9 organizations listed · 17 open questions + 21 unconnected-dot junctions

The condition in five sentences. PTSD is a trauma- and stressor-related disorder defined by a qualifying exposure, a patterned syndrome, persistence and impairment—not by trauma exposure alone. DSM-5 and ICD-11 identify overlapping but non-identical cases, and ICD-11 adds complex PTSD, leaving a live transportability problem for trials built under DSM definitions (Cloitre 2018, PMID 30178492). Trauma-focused CBT variants and EMDR have the strongest comparative evidence, but active-comparator differences, dropout and long-term function are less certain than waitlist-referenced symptom effects (Mavranezouli 2020, PMID 32063234; McLean 2022, PMID 34954460). Medication evidence is narrower — SSRIs improve response versus placebo (RR 0.66, 95% CI 0.59–0.74) but only sertraline and paroxetine are FDA-approved — and prazosin illustrates unresolved heterogeneity, because three positive trials and two meta-analyses favouring it sit alongside a 304-person null re-test (Williams 2022, PMID 35234292; Raskind 2018, PMID 29414272; Yücel 2020, PMID 31855732). MDMA-assisted therapy produced two positive phase 3 trials, but the FDA declined approval in August 2024 and required another phase 3 trial, so efficacy, safety, blinding and regulation remain separate questions (Mitchell 2021, PMID 33972795; Mitchell 2023, PMID 37709999; Morland 2026, PMID 41820235). Three sponsor-authored pooled phase 2 analyses were retracted in 2024; none is cited here as evidence (Mithoefer 2024, PMID 39126501).

Start here: overview. Research frontier: OPEN-QUESTIONS.md. Growth history: LOG.md.

Scope and pooling rule

  • PTSD owns the disorder, not trauma exposure in general.
  • PTSD and generalized anxiety disorder are neighbours, not subsets. Mixed-anxiety estimates are labelled and only PTSD strata are used as PTSD effects.
  • Comorbid depression is cross-linked rather than absorbed.
  • Complex PTSD is in scope as an ICD-11 sibling diagnosis and unresolved treatment-transport problem.

Reading paths

Wiki pages

Section Page Scope Status
Overview overview.md Post-traumatic stress disorder — Overview curated
Diagnosis diagnosis-and-classification.md PTSD — Diagnosis and classification draft — edited at 2026-10-23 sweep, awaiting audit
Complex-Ptsd complex-ptsd.md Complex PTSD draft — demoted at 2026-10-23 sweep, awaiting audit
Epidemiology epidemiology-and-risk.md PTSD — Epidemiology and risk curated
Neurobiology neurobiology-and-mechanism.md PTSD — Neurobiology and mechanism curated
Prolonged-Exposure prolonged-exposure.md Prolonged exposure for PTSD curated
Cognitive-Processing-Therapy cognitive-processing-therapy.md Cognitive processing therapy for PTSD curated
Emdr emdr.md Eye movement desensitization and reprocessing curated
Psychotherapy comparative-psychotherapy-evidence.md PTSD — Comparative psychotherapy evidence draft — edited at 2026-10-09 sweep, awaiting audit
Dropout dropout-and-nonresponse.md PTSD treatment dropout and nonresponse draft — edited at 2026-10-09 sweep, awaiting audit
Pharmacotherapy pharmacotherapy.md PTSD pharmacotherapy draft — edited at 2026-10-09 sweep, awaiting audit
Sleep sleep-and-nightmare-treatment.md PTSD sleep and nightmare treatment curated
Mdma mdma-and-psychedelic-assisted-therapy.md MDMA and psychedelic-assisted therapy for PTSD draft — edited at 2026-10-23 sweep, awaiting audit
Prevention early-intervention-and-prevention.md PTSD early intervention and prevention draft — edited at 2026-10-09 sweep, awaiting audit
Military military-and-veteran-populations.md PTSD in military and veteran populations draft — demoted at 2026-10-23 sweep, awaiting audit
Children children-and-adolescents.md PTSD in children and adolescents draft — edited at 2026-10-09 sweep, awaiting audit
Comorbidity comorbidity.md PTSD comorbidity draft — edited at 2026-10-23 sweep, awaiting audit
Moral-Injury moral-injury.md Moral injury and PTSD curated
Guidelines guidelines.md PTSD clinical practice guidelines draft — see audit note
Safety red-flags-and-safety-concerns.md PTSD red flags and safety concerns draft — demoted at 2026-10-23 sweep, awaiting audit
Patient-Experience patient-experience-and-advocacy.md PTSD patient experience and advocacy curated
Clinical-Trials clinical-trials-landscape.md PTSD clinical trials landscape draft — edited at 2026-10-23 sweep, awaiting audit

Literature layer

Artifact Contents Status
BIBLIOGRAPHY.md 434 unique live-retrieved PubMed records; tags and cited-by index draft
notes/ 6 landmark deep notes curated
guidelines/REGISTRY.md Current and superseded international guidance; disagreements and watch list draft
statistics/STATISTICS.md Definition-preserving quantitative reference tables draft
patient-voice/ Ethics/method, 9 organizations, 10 themes, annotated sources curated

Curation state

The 22 pages were written by Codex from live PubMed E-utilities and ClinicalTrials.gov v2 queries on 2026-09-02, then independently audited by Claude on the same date. No model audited its own writing.

The audit re-fetched all 385 PMIDs and 15 NCT IDs live, checked 659 reference lines, 655 evidence-ledger rows and every claim-to-citation pair on every page, re-ran the searches behind each asserted absence, and fixed what was wrong rather than only reporting it. 21 pages passed and are now status: curated.

guidelines.md remains draft for one specific reason: three of its load-bearing facts rest on issuing-body web pages rather than PubMed records, and those could not be independently re-fetched from the audit session — healthquality.va.gov failed at the TLS layer, and istss.org returned its content client-side so the 361-RCT/208-meta-analysis/125-recommendation counts could not be read from the raw HTML. The VA/DoD guideline has since been re-anchored to its peer-reviewed synopsis (Schnurr 2024, PMID 38408360), which independently confirms the 34-recommendation figure. Separately, NICE's NG116 evidence page lists a July 2026 exceptional surveillance whose decision document returned HTTP 403; until its outcome is known, describing NG116 as unchanged since April 2025 would be an assumption rather than a finding. That is the first item for the next sweep.

2026-10-23 sweep (Grok). Twelve PubMed records were added. Complex PTSD, military and veteran populations, and safety were demoted to draft because their text changed. Diagnosis, comorbidity, MDMA and psychedelics, and the trials landscape were already draft and were edited again. The NICE evidence index was re-checked and still lists the July 2026 exceptional surveillance as its latest entry; the decision document was not re-opened. No page was promoted. An independent audit is pending.