Osteoarthritis — master bibliography

Last updated: 2026-08-31 · unique PubMed records cited across condition artifacts (deepening pass added landmark trials and competing-guideline sources).

Every PMID below was returned by live PubMed E-utilities in the build session. A paper appears once under the first artifact topic that introduced it; cited by records every current condition use.

Index

• Bedson J, Croft PR. The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature. BMC Musculoskelet Disord. 2008;9;116. PMID 18764949 — tags: [INDEX] — cited by: INDEX, literature/statistics/STATISTICS
• Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377(9783);2115-26. PMID 21684382 — tags: [INDEX] — cited by: INDEX, wiki/hip-osteoarthritis, wiki/overview
• Skou ST, Roos EM, Laursen MB, et al. A Randomized, Controlled Trial of Total Knee Replacement. N Engl J Med. 2015;373(17);1597-606. PMID 26488691 — tags: [INDEX] — cited by: INDEX, LOG, OPEN-QUESTIONS, literature/notes/skou-2015-knee-replacement, literature/statistics/STATISTICS, wiki/overview
• Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care Res (Hoboken). 2020;72(2);149-162. PMID 31908149 — tags: [INDEX] — cited by: INDEX, OPEN-QUESTIONS, literature/guidelines/REGISTRY, literature/notes/kolasinski-2020-acr-guideline, wiki/diagnosis-and-classification, wiki/epidemiology-and-burden, wiki/guidelines, wiki/overview
• Cho Y, Jeong S, Kim H, et al. Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions. Exp Mol Med. 2021;53(11);1689-1696. PMID 34848838 — tags: [INDEX] — cited by: INDEX, OPEN-QUESTIONS, wiki/disease-modifying-therapies, wiki/overview
• da Costa BR, Pereira TV, Saadat P, et al. Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis: network meta-analysis. BMJ. 2021;375;n2321. PMID 34642179 — tags: [INDEX] — cited by: INDEX, literature/statistics/STATISTICS, wiki/clinical-trials-landscape, wiki/epidemiology-and-burden, wiki/overview, wiki/pharmacologic-treatment, wiki/red-flags-and-safety-concerns
• Dainese P, Wyngaert KV, De Mits S, et al. Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review. Osteoarthritis Cartilage. 2022;30(4);516-534. PMID 34968719 — tags: [INDEX] — cited by: INDEX, OPEN-QUESTIONS, wiki/cartilage-bone-and-synovium, wiki/overview, wiki/pain-mechanisms-and-sensitization
• GBD 2021 Osteoarthritis Collaborators. Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5(9);e508-e522. PMID 37675071 — tags: [INDEX] — cited by: INDEX, literature/notes/gbd-2023-global-burden, literature/statistics/STATISTICS, wiki/epidemiology-and-burden, wiki/exercise-weight-and-self-management, wiki/genetics-and-risk-factors, wiki/overview

Open Questions

• de Santana GN, Dibai-Filho AV, da Silva Júnior JEF, et al. Association between adherence to a home exercise program and central sensitization, pain intensity, and functionality in individuals with knee osteoarthritis. BMC Musculoskelet Disord. 2022;23(1):989. PMID 36397008 — tags: [open-questions, audit-2026-08-30] — cited by: OPEN-QUESTIONS.md
• Kawamura K, Sasaki E, Tsushima T, et al. Relationships Among Bone Marrow Lesions, Cartilage Improvement, and Short- to Midterm Patient-Reported Outcomes After Opening-Wedge High Tibial Osteotomy. Orthop J Sports Med. 2026;14(4):23259671261425635. PMID 42004451 — tags: [open-questions, audit-2026-08-30] — cited by: OPEN-QUESTIONS.md
• Lu C, Wang L, Cao X, et al. Integrated post-GWAS, single-cell, and functional analyses prioritize TCTN2 at an osteoarthritis locus associated with innate immunity-related cartilage remodeling. Front Immunol. 2026;17:1883412. PMID 42519341 — tags: [open-questions, audit-2026-08-30] — cited by: OPEN-QUESTIONS.md
• Saw MM, Kruger-Jakins T, Edries N, et al. Significant improvements in pain after a six-week physiotherapist-led exercise and education intervention, in patients with osteoarthritis awaiting arthroplasty, in South Africa: a randomised controlled trial. BMC Musculoskelet Disord. 2016;17:236. PMID 27233479 — tags: [open-questions, audit-2026-08-30] — cited by: OPEN-QUESTIONS.md
• MacFarlane LA, Williams EE, Lenhard NK, et al. Factors Influencing Physician Recommendation for Intraarticular Therapies in Osteoarthritis: Results From a Qualitative Study. Arthritis Care Res (Hoboken). 2022;74(4):617-625. PMID 33166060 — tags: [open-questions, audit-2026-08-30] — cited by: OPEN-QUESTIONS.md

• Tchetina E, Glemba K, Yunitskaya A, et al. Cathepsin S Upregulation Measured in the Peripheral Blood Mononuclear Cells Prior to Surgery Points to Postoperative Pain Development in Patients with Hip Osteoarthritis. Diagnostics (Basel). 2023;13(10):1739. PMID 37238223 — tags: [open-questions, audit-2026-08-30] — cited by: OPEN-QUESTIONS.md

• Yusuf E, Kortekaas MC, Watt I, et al. Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review. Ann Rheum Dis. 2011;70(1);60-7. PMID 20829200 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/biomarkers-and-imaging-markers, wiki/pain-mechanisms-and-sensitization

• McWilliams DF, Leeb BF, Muthuri SG, et al. Occupational risk factors for osteoarthritis of the knee: a meta-analysis. Osteoarthritis Cartilage. 2011;19(7);829-39. PMID 21382500 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS
• Messier SP, Mihalko SL, Legault C, et al. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013;310(12);1263-73. PMID 24065013 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/notes/messier-2013-idea, literature/statistics/STATISTICS, wiki/exercise-weight-and-self-management, wiki/overview
• Nelson AE, Smith MW, Golightly YM, et al. "Generalized osteoarthritis": a systematic review. Semin Arthritis Rheum. 2014;43(6);713-20. PMID 24461078 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/biomarkers-and-imaging-markers, wiki/overview
• Zhou ZY, Liu YK, Chen HL, et al. Body mass index and knee osteoarthritis risk: a dose-response meta-analysis. Obesity (Silver Spring). 2014;22(10);2180-5. PMID 24990315 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS, wiki/genetics-and-risk-factors
• Wang ZY, Shi SY, Li SJ, et al. Efficacy and Safety of Duloxetine on Osteoarthritis Knee Pain: A Meta-Analysis of Randomized Controlled Trials. Pain Med. 2015;16(7);1373-85. PMID 26176791 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS, wiki/pharmacologic-treatment
• Fransen M, McConnell S, Harmer AR, et al. Exercise for osteoarthritis of the knee: a Cochrane systematic review. Br J Sports Med. 2015;49(24);1554-7. PMID 26405113 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS, wiki/exercise-weight-and-self-management, wiki/overview
• Dell'Isola A, Allan R, Smith SL, et al. Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature. BMC Musculoskelet Disord. 2016;17(1);425. PMID 27733199 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS
• Isla Pera P, Ferrér MC, Nuñez Juarez M, et al. Obesity, knee osteoarthritis, and polypathology: factors favoring weight loss in older people. Patient Prefer Adherence. 2016;10;957-65. PMID 27313449 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• Roemer FW, Guermazi A, Collins JE, et al. Semi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort - Methodologic aspects and definition of change. BMC Musculoskelet Disord. 2016;17(1);466. PMID 27832771 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/biomarkers-and-imaging-markers
• van Middelkoop M, Arden NK, Atchia I, et al. The OA Trial Bank: meta-analysis of individual patient data from knee and hip osteoarthritis trials show that patients with severe pain exhibit greater benefit from intra-articular glucocorticoids. Osteoarthritis Cartilage. 2016;24(7);1143-52. PMID 26836288 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS
• McAlindon TE, LaValley MP, Harvey WF, et al. Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial. JAMA. 2017;317(19);1967-1975. PMID 28510679 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/notes/mcalindon-2017-triamcinolone, literature/statistics/STATISTICS, wiki/injections-and-orthobiologics, wiki/overview
• Styrkarsdottir U, Lund SH, Thorleifsson G, et al. Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. Nat Genet. 2018;50(12);1681-1687. PMID 30374069 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS, wiki/genetics-and-risk-factors
• Watt FE. Osteoarthritis biomarkers: year in review. Osteoarthritis Cartilage. 2018;26(3);312-318. PMID 29107060 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/overview
• Agaliotis M, Mackey MG, Jan S, et al. Perceptions of working with chronic knee pain: A qualitative study. Work. 2018;61(3);379-390. PMID 30373994 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/patient-voice/sources, literature/patient-voice/themes
• Bannuru RR, Osani MC, Vaysbrot EE, et al. OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis. Osteoarthritis Cartilage. 2019;27(11);1578-1589. PMID 31278997 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/guidelines/REGISTRY, wiki/guidelines, wiki/overview
• Saberi Hosnijeh F, Bierma-Zeinstra SM, Bay-Jensen AC. Osteoarthritis year in review 2018: biomarkers (biochemical markers). Osteoarthritis Cartilage. 2019;27(3);412-423. PMID 30552966 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/biomarkers-and-imaging-markers, wiki/overview
• Zhang W. The powerful placebo effect in osteoarthritis. Clin Exp Rheumatol. 2019;37 Suppl 120(5);118-123. PMID 31621561 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS
• Toupin April K, Bisaillon J, Welch V, et al. Tramadol for osteoarthritis. Cochrane Database Syst Rev. 2019;5(5);CD005522. PMID 31132298 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS
• Wluka AE, Yan MK, Lim KY, et al. Does preoperative neuropathic-like pain and central sensitisation affect the post-operative outcome of knee joint replacement for osteoarthritis? A systematic review and meta analysis. Osteoarthritis Cartilage. 2020;28(11);1403-1411. PMID 32791103 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/pain-mechanisms-and-sensitization
• Sabha M, Siaton BC, Hochberg MC. Lorecivivint, an intra-articular potential disease-modifying osteoarthritis drug. Expert Opin Investig Drugs. 2020;29(12);1339-1346. PMID 33096010 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/overview
• Al-Omari B, McMeekin P. Patients' Preferences Regarding Osteoarthritis Medications: An Adaptive Choice-Based Conjoint Analysis Study. Patient Prefer Adherence. 2020;14;2501-2515. PMID 33376311 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/patient-voice/sources, wiki/patient-experience-and-advocacy
• Tang JZ, Nie MJ, Zhao JZ, et al. Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. J Orthop Surg Res. 2020;15(1);403. PMID 32912243 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/injections-and-orthobiologics, wiki/overview
• Panter C, Berry P, Chauhan D, et al. A qualitative exploration of the patient experience of erosive and non-erosive hand osteoarthritis. J Patient Rep Outcomes. 2021;5(1);18. PMID 33537932 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• Zeng C, Doherty M, Persson MSM, et al. Comparative efficacy and safety of acetaminophen, topical and oral non-steroidal anti-inflammatory drugs for knee osteoarthritis: evidence from a network meta-analysis of randomized controlled trials and real-world data. Osteoarthritis Cartilage. 2021;29(9);1242-1251. PMID 34174454 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS, wiki/overview, wiki/pharmacologic-treatment
• Jayakumar P, Moore MG, Furlough KA, et al. Comparison of an Artificial Intelligence-Enabled Patient Decision Aid vs Educational Material on Decision Quality, Shared Decision-Making, Patient Experience, and Functional Outcomes in Adults With Knee Osteoarthritis: A Randomized Clinical Trial. JAMA Netw Open. 2021;4(2);e2037107. PMID 33599773 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/patient-voice/sources, literature/patient-voice/themes
• Boer CG, Hatzikotoulas K, Southam L, et al. Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations. Cell. 2021;184(18);4784-4818.e17. PMID 34450027 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS, wiki/genetics-and-risk-factors
• Bennell KL, Paterson KL, Metcalf BR, et al. Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial. JAMA. 2021;326(20);2021-2030. PMID 34812863 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/notes/bennell-2021-restore, literature/statistics/STATISTICS, wiki/injections-and-orthobiologics, wiki/overview
• Gazendam A, Ekhtiari S, Bozzo A, et al. Intra-articular saline injection is as effective as corticosteroids, platelet-rich plasma and hyaluronic acid for hip osteoarthritis pain: a systematic review and network meta-analysis of randomised controlled trials. Br J Sports Med. 2021;55(5);256-261. PMID 32829298 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS
• Caesar U, Hansson-Olofsson E, Karlsson J, et al. A sense of being rejected: Patients' lived experiences of cancelled knee or hip replacement surgery. Scand J Caring Sci. 2022;36(4);1054-1063. PMID 33988862 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/patient-voice/sources, literature/patient-voice/themes
• Brophy RH, Fillingham YA. AAOS Clinical Practice Guideline Summary: Management of Osteoarthritis of the Knee (Nonarthroplasty), Third Edition. J Am Acad Orthop Surg. 2022;30(9);e721-e729. PMID 35383651 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/guidelines/REGISTRY, wiki/guidelines
• Webster KE, Hewett TE. Anterior Cruciate Ligament Injury and Knee Osteoarthritis: An Umbrella Systematic Review and Meta-analysis. Clin J Sport Med. 2022;32(2);145-152. PMID 33852440 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS, wiki/epidemiology-and-burden, wiki/genetics-and-risk-factors
• Kunze KN, Fontana MA, MacLean CH, et al. Defining the Patient Acceptable Symptom State for the HOOS JR and KOOS JR After Primary Total Joint Arthroplasty. J Bone Joint Surg Am. 2022;104(4);345-352. PMID 34958538 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS
• Kim MS, Kim JJ, Kang KH, et al. Diagnosis of Central Sensitization and Its Effects on Postoperative Outcomes following Total Knee Arthroplasty: A Systematic Review and Meta-Analysis. Diagnostics (Basel). 2022;12(5);1248. PMID 35626402 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/pain-mechanisms-and-sensitization
• Previtali D, Capone G, Marchettini P, et al. High Prevalence of Pain Sensitization in Knee Osteoarthritis: A Meta-Analysis with Meta-Regression. Cartilage. 2022;13(1);19476035221087698. PMID 35356833 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS, wiki/pain-mechanisms-and-sensitization
• Brown MT, Cornblath DR, Koltzenburg M, et al. Peripheral Nerve Safety of Nerve Growth Factor Inhibition by Tanezumab: Pooled Analyses of Phase III Clinical Studies in Over 5000 Patients with Osteoarthritis. Clin Drug Investig. 2023;43(7);551-563. PMID 37460782 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/overview
• Marriott KA, Hall M, Maciukiewicz JM, et al. Are the Effects of Resistance Exercise on Pain and Function in Knee and Hip Osteoarthritis Dependent on Exercise Volume, Duration, and Adherence? A Systematic Review and Meta-Analysis. Arthritis Care Res (Hoboken). 2024;76(6);821-830. PMID 38317328 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/hip-osteoarthritis
• Wang Q, Runhaar J, Kloppenburg M, et al. Evaluation of the Diagnostic Performance of American College of Rheumatology, EULAR, and National Institute for Health and Clinical Excellence Criteria Against Clinically Relevant Knee Osteoarthritis: Data From the CHECK Cohort. Arthritis Care Res (Hoboken). 2024;76(4);511-516. PMID 37933434 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/diagnosis-and-classification
• Alyousef YS, Ross MH, Johnston V, et al. Experiences of Working with Lower Limb Osteoarthritis: A Qualitative Study. J Occup Rehabil. 2024;34(3);683-692. PMID 37995059 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• Bliddal H, Bays H, Czernichow S, et al. Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis. N Engl J Med. 2024;391(17);1573-1583. PMID 39476339 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, literature/statistics/STATISTICS, wiki/overview
• Kiadaliri A, Cronström A, Dahlberg LE, et al. Patient acceptable symptom state and treatment failure threshold values for work productivity and activity Impairment and EQ-5D-5L in osteoarthritis. Qual Life Res. 2024;33(5);1257-1266. PMID 38409279 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS
• Runhaar J, Özbulut Ö, Kloppenburg M, et al. Two-year clinical follow-up enhances the diagnosis of early-stage hip osteoarthritis: data from check cohort. RMD Open. 2024;10(2);e004208. PMID 38862243 — tags: [OPEN-QUESTIONS] — cited by: OPEN-QUESTIONS, wiki/diagnosis-and-classification

Literature — Guidelines — Registry

• Zhang W, Doherty M, Leeb BF, et al. EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2007;66(3);377-88. PMID 17046965 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/guidelines
• Zhang W, Doherty M, Leeb BF, et al. EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis. 2009;68(1);8-17. PMID 18250111 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/guidelines
• Swierstra BA, Bijlsma JW, de Beer JJ, et al. [Guideline 'Diagnostics and treatment of osteoarthrosis of the hip and knee']. Ned Tijdschr Geneeskd. 2009;153;B39. PMID 19818192 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY
• Hochberg MC, Altman RD, April KT, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2012;64(4);465-74. PMID 22563589 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY
• Manara M, Bortoluzzi A, Favero M, et al. Italian Society for Rheumatology recommendations for the management of hand osteoarthritis. Reumatismo. 2013;65(4);167-85. PMID 24192562 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/guidelines
• Jevsevar DS. Treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition. J Am Acad Orthop Surg. 2013;21(9);571-6. PMID 23996988 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/guidelines
• Loyola-Sanchez A, Richardson J, Pelaez-Ballestas I, et al. Barriers to implementing the "2008 Mexican Clinical Practice Guideline recommendations for the management of hip and knee osteoarthritis" in primary healthcare practice. Reumatol Clin. 2014;10(6);364-72. PMID 24909101 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY
• McAlindon TE, Bannuru RR, Sullivan MC, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014;22(3);363-88. PMID 24462672 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/patient-experience-and-advocacy, wiki/pharmacologic-treatment
• Weber KL, Jevsevar DS, McGrory BJ. AAOS Clinical Practice Guideline: Surgical Management of Osteoarthritis of the Knee: Evidence-based Guideline. J Am Acad Orthop Surg. 2016;24(8);e94-6. PMID 27355287 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/guidelines
• Sakellariou G, Conaghan PG, Zhang W, et al. EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis. Ann Rheum Dis. 2017;76(9);1484-1494. PMID 28389554 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/guidelines
• Kroon FPB, Carmona L, Schoones JW, et al. Efficacy and safety of non-pharmacological, pharmacological and surgical treatment for hand osteoarthritis: a systematic literature review informing the 2018 update of the EULAR recommendations for the management of hand osteoarthritis. RMD Open. 2018;4(2);e000734. PMID 30402266 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/guidelines
• Kloppenburg M, Kroon FP, Blanco FJ, et al. 2018 update of the EULAR recommendations for the management of hand osteoarthritis. Ann Rheum Dis. 2019;78(1);16-24. PMID 30154087 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/guidelines
• Kucharz EJ, Szántó S, Ivanova Goycheva M, et al. Endorsement by Central European experts of the revised ESCEO algorithm for the management of knee osteoarthritis. Rheumatol Int. 2019;39(7);1117-1123. PMID 31129712 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY
• van Doormaal MCM, Meerhoff GA, Vliet Vlieland TPM, et al. A clinical practice guideline for physical therapy in patients with hip or knee osteoarthritis. Musculoskeletal Care. 2020;18(4);575-595. PMID 32643252 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY
• Ayhan FF, Sunar İ, Umay E, et al. The Turkish League Against Rheumatism Recommendations for the Management of Hand Osteoarthritis Under Guidance of the Current Literature and 2018 European League Against Rheumatism Recommendations. Arch Rheumatol. 2020;35(3);309-320. PMID 33458653 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/guidelines
• Uson J, Rodriguez-García SC, Castellanos-Moreira R, et al. EULAR recommendations for intra-articular therapies. Ann Rheum Dis. 2021;80(10);1299-1305. PMID 34035002 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY
• Pers YM, Nguyen C, Borie C, et al. Recommendations from the French Societies of Rheumatology and Physical Medicine and Rehabilitation on the non-pharmacological management of knee osteoarthritis. Ann Phys Rehabil Med. 2024;67(7);101883. PMID 39490291 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/knee-osteoarthritis
• Courties A, Daste C, Homs AF, et al. French Societies of Rheumatology and of Physical and Rehabilitation Medicine recommendations for the management of people living with hand osteoarthritis. Joint Bone Spine. 2026;93(2);106000. PMID 41183591 — tags: [literature-guidelines-REGISTRY] — cited by: literature/guidelines/REGISTRY, wiki/guidelines

Literature — Patient Voice — Sources

• Bozic KJ, Chiu V, Slover JD, et al. Patient preferences and willingness to pay for arthroplasty surgery in patients with osteoarthritis of the hip. J Arthroplasty. 2012;27(4);503-506.e2. PMID 21955791 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• Stamm T, Hieblinger R, Boström C, et al. Similar problem in the activities of daily living but different experience: a qualitative analysis in six rheumatic conditions and eight European countries. Musculoskeletal Care. 2014;12(1);22-33. PMID 23362188 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes
• Maillette P, Coutu MF, Gaudreault N. Workers' perspectives on return to work after total knee arthroplasty. Ann Phys Rehabil Med. 2017;60(5);299-305. PMID 28347691 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• Hurley M, Dickson K, Hallett R, et al. Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review. Cochrane Database Syst Rev. 2018;4(4);CD010842. PMID 29664187 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes, wiki/diagnosis-and-classification, wiki/exercise-weight-and-self-management, wiki/patient-experience-and-advocacy
• O'Brien P, Bunzli S, Ayton D, et al. What are the patient factors that impact on decisions to progress to total knee replacement? A qualitative study involving patients with knee osteoarthritis. BMJ Open. 2019;9(9);e031310. PMID 31551388 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• Rivero-Santana A, Torrente-Jiménez RS, Perestelo-Pérez L, et al. Effectiveness of a decision aid for patients with knee osteoarthritis: a randomized controlled trial. Osteoarthritis Cartilage. 2021;29(9);1265-1274. PMID 34174455 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes
• Teo PL, Bennell KL, Lawford B, et al. Patient experiences with physiotherapy for knee osteoarthritis in Australia-a qualitative study. BMJ Open. 2021;11(3);e043689. PMID 34006028 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• Bansback N, Trenaman L, MacDonald KV, et al. An online individualised patient decision aid improves the quality of decisions in patients considering total knee arthroplasty in routine care: A randomized controlled trial. Osteoarthr Cartil Open. 2022;4(3);100286. PMID 36474942 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes
• Taylor CEV, Murray CM, Stanton TR. Patient perspectives of pain and function after knee replacement: a systematic review and meta-synthesis of qualitative studies. Pain Rep. 2022;7(3);e1006. PMID 35558092 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes
• Yang SY, Woon EYS, Griva K, et al. A Qualitative Study of Psychosocial Factors in Patients With Knee Osteoarthritis: Insights Learned From an Asian Population. Clin Orthop Relat Res. 2023;481(5);874-884. PMID 36580492 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• Thom JM, Dennis S, Gibson KA, et al. Knee osteoarthritis patient perspectives of their care in an australian private physiotherapy setting: a qualitative exploratory interview study. BMC Musculoskelet Disord. 2023;24(1);564. PMID 37434180 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• O'Brien P, Prehn R, Green C, et al. Understanding the Impact and Tackling the Burden of Osteoarthritis for Aboriginal and Torres Strait Islander People. Arthritis Care Res (Hoboken). 2023;75(1);125-135. PMID 36214055 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• King LK, Mahmoudian A, Waugh EJ, et al. "You don't put it down to arthritis": A qualitative study of the first symptoms recalled by individuals with knee osteoarthritis. Osteoarthr Cartil Open. 2024;6(1);100428. PMID 38229918 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• Te Molder MEM, Vriezekolk JE, van Onsem S, et al. Exploration of adverse consequences of total knee arthroplasty by patients and knee specialists: a qualitative study. Rheumatol Adv Pract. 2024;8(1);rkad111. PMID 38152392 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy
• Reischl S, Ziebart C, Johnston Z, et al. Patient Experience of Stiffness With Knee Osteoarthritis: An Interpretative Description Study. Musculoskeletal Care. 2024;22(3);e1922. PMID 39073278 — tags: [literature-patient-voice-sources] — cited by: literature/patient-voice/sources, literature/patient-voice/themes, wiki/patient-experience-and-advocacy

Literature — Patient Voice — Themes

• Zou Q, Chen N, Cheng J, et al. The Illness Experience of Patients With Knee Osteoarthritis: A Qualitative Study. J Eval Clin Pract. 2025;31(5);e70235. PMID 40762627 — tags: [literature-patient-voice-themes] — cited by: literature/patient-voice/themes, wiki/patient-experience-and-advocacy

Literature — Statistics — Statistics

• Sihvonen R, Paavola M, Malmivaara A, et al. Arthroscopic partial meniscectomy versus sham surgery for a degenerative meniscal tear. N Engl J Med. 2013;369(26);2515-24. PMID 24369076 — tags: [literature-statistics-STATISTICS] — cited by: literature/statistics/STATISTICS, wiki/knee-osteoarthritis
• Fingleton C, Smart K, Moloney N, et al. Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2015;23(7);1043-56. PMID 25749012 — tags: [literature-statistics-STATISTICS] — cited by: literature/statistics/STATISTICS, wiki/pain-mechanisms-and-sensitization
• Wilson HA, Middleton R, Abram SGF, et al. Patient relevant outcomes of unicompartmental versus total knee replacement: systematic review and meta-analysis. BMJ. 2019;364;l352. PMID 30792179 — tags: [literature-statistics-STATISTICS] — cited by: literature/statistics/STATISTICS, wiki/overview
• Zolio L, Lim KY, McKenzie JE, et al. Systematic review and meta-analysis of the prevalence of neuropathic-like pain and/or pain sensitization in people with knee and hip osteoarthritis. Osteoarthritis Cartilage. 2021;29(8);1096-1116. PMID 33971205 — tags: [literature-statistics-STATISTICS] — cited by: literature/statistics/STATISTICS, wiki/pain-mechanisms-and-sensitization
• Pereira TV, Jüni P, Saadat P, et al. Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis. BMJ. 2022;378;e069722. PMID 36333100 — tags: [literature-statistics-STATISTICS] — cited by: literature/statistics/STATISTICS, wiki/clinical-trials-landscape, wiki/epidemiology-and-burden
• Fan Z, Yan L, Liu H, et al. The prevalence of hip osteoarthritis: a systematic review and meta-analysis. Arthritis Res Ther. 2023;25(1);51. PMID 36991481 — tags: [literature-statistics-STATISTICS] — cited by: literature/statistics/STATISTICS, wiki/epidemiology-and-burden, wiki/overview

Wiki — Biomarkers And Imaging Markers

• Samuels J, Krasnokutsky S, Abramson SB. Osteoarthritis: a tale of three tissues. Bull NYU Hosp Jt Dis. 2008;66(3);244-50. PMID 18937640 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Chapple CM, Nicholson H, Baxter GD, et al. Patient characteristics that predict progression of knee osteoarthritis: a systematic review of prognostic studies. Arthritis Care Res (Hoboken). 2011;63(8);1115-25. PMID 21560257 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Blanco FJ. Osteoarthritis year in review 2014: we need more biochemical biomarkers in qualification phase. Osteoarthritis Cartilage. 2014;22(12);2025-32. PMID 25456298 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Glyn-Jones S, Palmer AJ, Agricola R, et al. Osteoarthritis. Lancet. 2015;386(9991);376-87. PMID 25748615 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers, wiki/overview
• Roux CH, Foltz V, Maheu E, et al. MRI and serum biomarkers correlate with radiographic features in painful hand osteoarthritis. Clin Exp Rheumatol. 2016;34(6);991-998. PMID 27749237 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Wu J, Wang K, Xu J, et al. Associations between serum ghrelin and knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee osteoarthritis. Osteoarthritis Cartilage. 2017;25(9);1428-1435. PMID 28602782 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Mobasheri A, Bay-Jensen AC, van Spil WE, et al. Osteoarthritis Year in Review 2016: biomarkers (biochemical markers). Osteoarthritis Cartilage. 2017;25(2);199-208. PMID 28099838 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Nguyen LT, Sharma AR, Chakraborty C, et al. Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis. Int J Mol Sci. 2017;18(3);601. PMID 28287489 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Oo WM, Linklater JM, Daniel M, et al. Clinimetrics of ultrasound pathologies in osteoarthritis: systematic literature review and meta-analysis. Osteoarthritis Cartilage. 2018;26(5);601-611. PMID 29426009 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Jin X, Antony B, Wang X, et al. Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis. BMJ Open. 2020;10(4);e035302. PMID 32332006 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• van Spil WE, Szilagyi IA. Osteoarthritis year in review 2019: biomarkers (biochemical markers). Osteoarthritis Cartilage. 2020;28(3);296-315. PMID 31887390 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Previtali D, Andriolo L, Di Laura Frattura G, et al. Pain Trajectories in Knee Osteoarthritis-A Systematic Review and Best Evidence Synthesis on Pain Predictors. J Clin Med. 2020;9(9);2828. PMID 32882828 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Martel-Pelletier J, Tardif G, Paiement P, et al. Common Biochemical and Magnetic Resonance Imaging Biomarkers of Early Knee Osteoarthritis and of Exercise/Training in Athletes: A Narrative Review. Diagnostics (Basel). 2021;11(8);1488. PMID 34441422 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Eseonu KC, Neale J, Lyons A, et al. Are Outcomes of Acute Meniscus Root Tear Repair Better Than Debridement or Nonoperative Management? A Systematic Review. Am J Sports Med. 2022;50(11);3130-3139. PMID 34633226 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Roemer FW, Jansen M, Marijnissen ACA, et al. Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort. BMC Musculoskelet Disord. 2022;23(1);988. PMID 36397054 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Wang X, Chen T, Liang W, et al. Synovitis mediates the association between bone marrow lesions and knee pain in osteoarthritis: data from the Foundation for the National Institute of Health (FNIH) Osteoarthritis Biomarkers Consortium. Osteoarthritis Cartilage. 2022;30(9);1270-1277. PMID 35750239 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Lynskey SJ, Macaluso MJ, Gill SD, et al. Biomarkers of Osteoarthritis-A Narrative Review on Causal Links with Metabolic Syndrome. Life (Basel). 2023;13(3);730. PMID 36983885 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Mourad C, Vande Berg B. Osteoarthritis of the hip: is radiography still needed? Skeletal Radiol. 2023;52(11);2259-2270. PMID 36538067 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Liu M, Haque N, Huang J, et al. Osteoarthritis year in review 2023: metabolite and protein biomarkers. Osteoarthritis Cartilage. 2023;31(11);1437-1453. PMID 37611797 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Runhaar J, van Middelkoop M, Oei EHG, et al. Potential surrogate outcomes in individuals at high risk for incident knee osteoarthritis. Osteoarthritis Cartilage. 2023;31(3);414-420. PMID 36646305 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Smith SE, Bahouth SM, Duryea J. Quantitative bone marrow lesion, meniscus, and synovitis measurement: current status. Skeletal Radiol. 2023;52(11);2123-2135. PMID 36928478 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Hannani MT, Thudium CS, Karsdal MA, et al. From biochemical markers to molecular endotypes of osteoarthritis: a review on validated biomarkers. Expert Rev Mol Diagn. 2024;24(1-2);23-38. PMID 38353446 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers, wiki/clinical-trials-landscape
• Roemer FW, Jansen MP, Maschek S, et al. Fluctuation of Bone Marrow Lesions and Inflammatory MRI Markers over 2 Years and Concurrent Associations with Quantitative Cartilage Loss. Cartilage. 2025;16(3);308-321. PMID 39460605 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Chlorogiannis DD, Taslakian B, Ahmed O, et al. Key Osteoarthritis Biomarkers: What Interventional Radiologists Performing Genicular Artery Embolization Need to Know. Cardiovasc Intervent Radiol. 2025;48(6);729-738. PMID 40399701 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Kelliher A, Beilharz SA, Sutton R. Efficacy of Intra-Articular Corticosteroid Injection for Hip Osteoarthritis: A Systematic Review with Meta-Analysis. J Arthroplasty. 2026;S0883-5403(26)00772-2. PMID 42462884 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Mohammadi S, Harandi H, Alikarami S, et al. MRI-defined tissue damage as predictors of the incidence and progression of knee osteoarthritis: A systematic review. Semin Arthritis Rheum. 2026;79;152999. PMID 42176660 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers
• Siddiq MAB, Duong V, Jia J, et al. Validity of ultrasound in knee osteoarthritis - A systematic review and meta-analysis. Osteoarthritis Cartilage. 2026;34(7);1007-1016. PMID 41831592 — tags: [wiki-biomarkers-and-imaging-markers] — cited by: wiki/biomarkers-and-imaging-markers

Wiki — Cartilage Bone And Synovium

• Charni-Ben Tabassi N, Garnero P. Monitoring cartilage turnover. Curr Rheumatol Rep. 2007;9(1);16-24. PMID 17437662 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Martel-Pelletier J, Boileau C, Pelletier JP, et al. Cartilage in normal and osteoarthritis conditions. Best Pract Res Clin Rheumatol. 2008;22(2);351-84. PMID 18455690 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Little CB, Fosang AJ. Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis--insights from studies of aggrecan and collagen proteolysis? Curr Drug Targets. 2010;11(5);561-75. PMID 20199393 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol. 2011;23(5);471-8. PMID 21788902 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Troeberg L, Nagase H. Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta. 2012;1824(1);133-45. PMID 21777704 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Scanzello CR, Goldring SR. The role of synovitis in osteoarthritis pathogenesis. Bone. 2012;51(2);249-57. PMID 22387238 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Li G, Yin J, Gao J, et al. Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes. Arthritis Res Ther. 2013;15(6);223. PMID 24321104 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Wang XD, Zhang JN, Gan YH, et al. Current understanding of pathogenesis and treatment of TMJ osteoarthritis. J Dent Res. 2015;94(5);666-73. PMID 25744069 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Funck-Brentano T, Cohen-Solal M. Subchondral bone and osteoarthritis. Curr Opin Rheumatol. 2015;27(4);420-6. PMID 26002035 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Muttigi MS, Han I, Park HK, et al. Matrilin-3 Role in Cartilage Development and Osteoarthritis. Int J Mol Sci. 2016;17(4);590. PMID 27104523 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Mathiessen A, Conaghan PG. Synovitis in osteoarthritis: current understanding with therapeutic implications. Arthritis Res Ther. 2017;19(1);18. PMID 28148295 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Luo Y, Sinkeviciute D, He Y, et al. The minor collagens in articular cartilage. Protein Cell. 2017;8(8);560-572. PMID 28213717 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Guilak F, Nims RJ, Dicks A, et al. Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biol. 2018;71-72;40-50. PMID 29800616 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Donell S. Subchondral bone remodelling in osteoarthritis. EFORT Open Rev. 2019;4(6);221-229. PMID 31210964 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Zhang H, Cai D, Bai X. Macrophages regulate the progression of osteoarthritis. Osteoarthritis Cartilage. 2020;28(5);555-561. PMID 31982565 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Zhu X, Chan YT, Yung PSH, et al. Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis. Front Cell Dev Biol. 2020;8;607764. PMID 33553146 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Sun K, Luo J, Guo J, et al. The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review. Osteoarthritis Cartilage. 2020;28(4);400-409. PMID 32081707 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Zeng CY, Zhang ZR, Tang ZM, et al. Benefits and Mechanisms of Exercise Training for Knee Osteoarthritis. Front Physiol. 2021;12;794062. PMID 34975542 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Hu W, Chen Y, Dou C, et al. Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis. Ann Rheum Dis. 2021;80(4);413-422. PMID 33158879 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Hu Y, Chen X, Wang S, et al. Subchondral bone microenvironment in osteoarthritis and pain. Bone Res. 2021;9(1);20. PMID 33731688 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Xu XL, Xue Y, Ding JY, et al. Nanodevices for deep cartilage penetration. Acta Biomater. 2022;154;23-48. PMID 36243371 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Jiang Y. Osteoarthritis year in review 2021: biology. Osteoarthritis Cartilage. 2022;30(2);207-215. PMID 34801671 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Rapp AE, Zaucke F. Cartilage extracellular matrix-derived matrikines in osteoarthritis. Am J Physiol Cell Physiol. 2023;324(2);C377-C394. PMID 36571440 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• De Roover A, Escribano-Núñez A, Monteagudo S, et al. Fundamentals of osteoarthritis: Inflammatory mediators in osteoarthritis. Osteoarthritis Cartilage. 2023;31(10);1303-1311. PMID 37353140 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Knights AJ, Redding SJ, Maerz T. Inflammation in osteoarthritis: the latest progress and ongoing challenges. Curr Opin Rheumatol. 2023;35(2);128-134. PMID 36695054 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Geng R, Li J, Yu C, et al. Knee osteoarthritis: Current status and research progress in treatment (Review). Exp Ther Med. 2023;26(4);481. PMID 37745043 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Oláh T, Cucchiarini M, Madry H. Subchondral bone remodeling patterns in larger animal models of meniscal injuries inducing knee osteoarthritis - a systematic review. Knee Surg Sports Traumatol Arthrosc. 2023;31(12);5346-5364. PMID 37742232 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Li Y, Fu T, Yu W, et al. Mesenchymal stem cells and extracellular vesicles for knee osteoarthritis: clinical application, mechanism exploration and prospect. Stem Cell Res Ther. 2025;16(1);688. PMID 41276868 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium
• Liu W, Guo NY, Wang JQ, et al. Osteoarthritis: Mechanisms and Therapeutic Advances. MedComm (2020). 2025;6(8);e70290. PMID 40757100 — tags: [wiki-cartilage-bone-and-synovium] — cited by: wiki/cartilage-bone-and-synovium

Wiki — Clinical Trials Landscape

• Gregori D, Giacovelli G, Minto C, et al. Association of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis. JAMA. 2018;320(24);2564-2579. PMID 30575881 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape, wiki/disease-modifying-therapies, wiki/epidemiology-and-burden, wiki/pharmacologic-treatment
• Miller RE, Block JA, Malfait AM. What is new in pain modification in osteoarthritis? Rheumatology (Oxford). 2018;57(suppl_4);iv99-iv107. PMID 29361112 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Hochberg MC, Guermazi A, Guehring H, et al. Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial. JAMA. 2019;322(14);1360-1370. PMID 31593273 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape, wiki/disease-modifying-therapies
• García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, et al. Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. Int Orthop. 2019;43(3);531-538. PMID 30368550 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Tachmazidou I, Hatzikotoulas K, Southam L, et al. Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. Nat Genet. 2019;51(2);230-236. PMID 30664745 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Fortuna R, Hart DA, Sharkey KA, et al. Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: study protocol for a randomized controlled trial. Trials. 2021;22(1);255. PMID 33827639 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Cai X, Yuan S, Zeng Y, et al. New Trends in Pharmacological Treatments for Osteoarthritis. Front Pharmacol. 2021;12;645842. PMID 33935742 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Filardo G, Previtali D, Napoli F, et al. PRP Injections for the Treatment of Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials. Cartilage. 2021;13(1_suppl);364S-375S. PMID 32551947 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Gerwin N, Scotti C, Halleux C, et al. Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial. Nat Med. 2022;28(12);2633-2645. PMID 36456835 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Chavda S, Rabbani SA, Wadhwa T. Role and Effectiveness of Intra-articular Injection of Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Systematic Review. Cureus. 2022;14(4);e24503. PMID 35651409 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Kim KI, Lee MC, Lee JH, et al. Clinical Efficacy and Safety of the Intra-articular Injection of Autologous Adipose-Derived Mesenchymal Stem Cells for Knee Osteoarthritis: A Phase III, Randomized, Double-Blind, Placebo-Controlled Trial. Am J Sports Med. 2023;51(9);2243-2253. PMID 37345256 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Assi R, Quintiens J, Monteagudo S, et al. Innovation in Targeted Intra-articular Therapies for Osteoarthritis. Drugs. 2023;83(8);649-663. PMID 37067759 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Rabade A, Viswanatha GL, Nandakumar K, et al. Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis. Inflammopharmacology. 2024;32(3);1759-1775. PMID 38581640 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Ehioghae M, Vippa TK, Askins D, et al. Exploring Orthopedic Stem-Cell Approaches for Osteoarthritis Management: Current Trends and Future Horizons. Curr Pain Headache Rep. 2024;28(1);27-35. PMID 38010488 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Grol MW. The evolving landscape of gene therapy strategies for the treatment of osteoarthritis. Osteoarthritis Cartilage. 2024;32(4);372-384. PMID 38199296 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Del Río E. A Multidimensional Definition of Pre-Osteoarthritis: Toward 21st-Century Subclinical Detection and Targeted Intervention. Int J Mol Sci. 2025;26(23);11447. PMID 41373603 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Simental-Mendía M, Ortega-Mata D, Acosta-Olivo CA, et al. Effect of collagen supplementation on knee osteoarthritis: an updated systematic review and meta-analysis of randomised controlled trials. Clin Exp Rheumatol. 2025;43(1);126-134. PMID 39212129 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Wang C, Yao B. Efficacy and safety of platelet-rich plasma injections for the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Eur J Med Res. 2025;30(1);992. PMID 41107915 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Lee BW, Lee JJ, Jung JY, et al. Intra-Articular Injection of Human Bone Marrow-Derived Mesenchymal Stem Cells in Knee Osteoarthritis: A Randomized, Double-Blind, Controlled Trial. Cell Transplant. 2025;34;9636897241303275. PMID 39874108 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Zhu Z, Yu Q, Leng X, et al. Low-Dose Methotrexate for the Treatment of Inflammatory Knee Osteoarthritis: A Randomized Clinical Trial. JAMA Intern Med. 2025;185(7);808-816. PMID 40455462 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Dell'Isola A, Recenti F, Giardulli B, et al. Osteoarthritis year in review 2025: Epidemiology and therapy. Osteoarthritis Cartilage. 2025;33(11);1300-1306. PMID 40914550 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Duong V, Abdel Shaheed C, Ferreira ML, et al. Risk factors for the development of knee osteoarthritis across the lifespan: A systematic review and meta-analysis. Osteoarthritis Cartilage. 2025;33(10);1162-1179. PMID 40174718 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape, wiki/epidemiology-and-burden, wiki/genetics-and-risk-factors
• Dong P, Zhao Q, Yang B, et al. Disease-Modifying Antirheumatic Drugs for Hand Osteoarthritis: A Systematic Review and Network Meta-analysis. Hand Surg Rehabil. 2026;102762. PMID 42632595 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Perry TA, Deng Y, Hulley PA, et al. Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum. Nat Commun. 2026;17(1);4721. PMID 42230587 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Zhong J, Yang G. Metabolic syndrome-osteoarthritis axis: Beyond mechanical loading toward a cardiometabolic OA phenotype. Biomed Pharmacother. 2026;200;119583. PMID 42190498 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Evans CH, Ghivizzani SC, Robbins PD. Osteoarthritis Gene Therapy: A 30-Year Journey From Concept to Clinical Trials. J Orthop Res. 2026;44(2);e70141. PMID 41607103 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape
• Heijman MWJ, Hartog M, van den Ende CHM, et al. The Potential of Authorised Drugs to be Repurposed for the Treatment of Osteoarthritis: A Scoping Review of Clinical Studies. Drugs. 2026;86(3);359-376. PMID 41619152 — tags: [wiki-clinical-trials-landscape] — cited by: wiki/clinical-trials-landscape

Wiki — Diagnosis And Classification

• Bauer HW, Klasser M, von Hanstein KL, et al. Oxaceprol is as effective as diclofenac in the therapy of osteoarthritis of the knee and hip. Clin Rheumatol. 1999;18(1);4-9. PMID 10088941 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Lievense AM, Bierma-Zeinstra SM, Verhagen AP, et al. Influence of obesity on the development of osteoarthritis of the hip: a systematic review. Rheumatology (Oxford). 2002;41(10);1155-62. PMID 12364636 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• D'Agostino MA, Conaghan P, Le Bars M, et al. EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: prevalence of inflammation in osteoarthritis. Ann Rheum Dis. 2005;64(12);1703-9. PMID 15878903 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Turajane T, Tanavaree A, Labpiboonpong V, et al. Outcomes of intra-articular injection of sodium hyaluronate for the treatment of osteoarthritis of the knee. J Med Assoc Thai. 2007;90(9);1845-52. PMID 17957929 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Henrotin Y, Mobasheri A, Marty M. Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis? Arthritis Res Ther. 2012;14(1);201. PMID 22293240 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Abbott JH, Robertson MC, Chapple C, et al. Manual therapy, exercise therapy, or both, in addition to usual care, for osteoarthritis of the hip or knee: a randomized controlled trial. 1: clinical effectiveness. Osteoarthritis Cartilage. 2013;21(4);525-34. PMID 23313532 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification, wiki/hip-osteoarthritis
• Yoshida K, Barr RJ, Galea-Soler S, et al. Reproducibility and Diagnostic Accuracy of Kellgren-Lawrence Grading for Osteoarthritis Using Radiographs and Dual-Energy X-ray Absorptiometry Images. J Clin Densitom. 2015;18(2);239-44. PMID 25304911 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Hayes B, Kittelson A, Loyd B, et al. Assessing Radiographic Knee Osteoarthritis: An Online Training Tutorial for the Kellgren-Lawrence Grading Scale. MedEdPORTAL. 2016;12;10503. PMID 30984845 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Mohammed RHA, Kotb H, Amir M, et al. Subclinical crystal arthropathy: a silent contributor to inflammation and functional disability in knees with osteoarthritis-an ultrasound study. J Med Ultrason (2001). 2019;46(1);137-146. PMID 30327988 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Ferguson RJ, Prieto-Alhambra D, Walker C, et al. Validation of hip osteoarthritis diagnosis recording in the UK Clinical Practice Research Datalink. Pharmacoepidemiol Drug Saf. 2019;28(2);187-193. PMID 30375101 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Skou ST, Koes BW, Grønne DT, et al. Comparison of three sets of clinical classification criteria for knee osteoarthritis: a cross-sectional study of 13,459 patients treated in primary care. Osteoarthritis Cartilage. 2020;28(2);167-172. PMID 31539621 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Olsson S, Akbarian E, Lind A, et al. Automating classification of osteoarthritis according to Kellgren-Lawrence in the knee using deep learning in an unfiltered adult population. BMC Musculoskelet Disord. 2021;22(1);844. PMID 34600505 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Eckersley T, Faulkner J, Al-Dadah O. Inter- and intra-observer reliability of radiological grading systems for knee osteoarthritis. Skeletal Radiol. 2021;50(10);2069-2078. PMID 33855593 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Atsma F, Molenkamp O, Bouma H, et al. Uniform criteria for total hip replacement surgery in patients with hip osteoarthritis: a decision tool to guide treatment decisions. Int J Qual Health Care. 2021;33(1);mzab030. PMID 33616656 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• French HP, Abbott JH, Galvin R. Adjunctive therapies in addition to land-based exercise therapy for osteoarthritis of the hip or knee. Cochrane Database Syst Rev. 2022;10(10);CD011915. PMID 36250418 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification, wiki/exercise-weight-and-self-management
• Lee SH, Kao CC, Liang HW, et al. Validity of the Osteoarthritis Research Society International (OARSI) recommended performance-based tests of physical function in individuals with symptomatic Kellgren and Lawrence grade 0-2 knee osteoarthritis. BMC Musculoskelet Disord. 2022;23(1);1040. PMID 36451167 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Hu C, Zhu B, Wang Y, et al. Effectiveness of blood flow restriction versus traditional weight-bearing training in rehabilitation of knee osteoarthritis patients with MASLD: a multicenter randomized controlled trial. Front Endocrinol (Lausanne). 2023;14;1220758. PMID 38155949 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Longo UG, de Sire A, De Salvatore S, et al. Imaging of glenohumeral osteoarthritis: Reliability and reproducibility of radiological classifications. J Back Musculoskelet Rehabil. 2024;37(6);1729-1739. PMID 39093064 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Ilahi OA. International Knee Documentation Committee Radiographic Knee Joint Grading More Reliable Than Kellgren-Lawrence Grading and Other Grading Systems. Arthroscopy. 2024;40(5);1716-1719. PMID 38092278 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Han S, Li T, Cao Y, et al. Quantitative analysis of effectiveness and associated factors of exercise on symptoms in osteoarthritis: a pharmacodynamic model-based meta-analysis. Br J Sports Med. 2024;58(24);1539-1550. PMID 39393837 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Okamoto Y, Wakama H, Nakamura K, et al. Worse Patient-Reported Outcomes and Spino-Pelvic Parameters After Total Hip Arthroplasty for Rapidly Progressive Osteoarthritis of the Hip Compared to Osteoarthritis: A Propensity-Matched Cohort Study. J Arthroplasty. 2024;39(9);2303-2310. PMID 38608844 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Drummen SJJ, Runhaar J, Bierma-Zeinstra SM, et al. Early-stage vs established knee osteoarthritis: A comparative observational study on prevalence and changes in pain, function and quality of life after supervised exercise and education among 10,365 patients. Osteoarthritis Cartilage. 2025;33(3);364-372. PMID 39617203 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Guede-Rojas F, Mendoza C, Rodríguez-Lagos L, et al. Effects of Non-Immersive Virtual Reality Exercise on Self-Reported Pain and Mechanical Hyperalgesia in Older Adults with Knee and Hip Osteoarthritis: A Secondary Analysis of a Randomized Controlled Trial. Medicina (Kaunas). 2025;61(7);1122. PMID 40731752 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Alhasan MK, Obeidat N, Al Bdour IR, et al. Radiographic predictors of knee osteoarthritis. Radiography (Lond). 2025;31(5);103086. PMID 40639313 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Zhang H, Kong C, Chang H, et al. Automated Kellgren-Lawrence grading of knee osteoarthritis using a multi-scale attention-based deep learning framework. Front Med (Lausanne). 2026;13;1809768. PMID 42375198 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification
• Khela MS, Lee T, Mulford KL, et al. Minimum joint space width demonstrates higher inter-and intra-observer reliability than Kellgren-Lawrence grading in knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2026;10.1002/ksa.70395. PMID 41979362 — tags: [wiki-diagnosis-and-classification] — cited by: wiki/diagnosis-and-classification

Wiki — Disease Modifying Therapies

• Lohmander LS, Hellot S, Dreher D, et al. Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial. Arthritis Rheumatol. 2014;66(7);1820-31. PMID 24740822 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Dahlberg LE, Aydemir A, Muurahainen N, et al. A first-in-human, double-blind, randomised, placebo-controlled, dose ascending study of intra-articular rhFGF18 (sprifermin) in patients with advanced knee osteoarthritis. Clin Exp Rheumatol. 2016;34(3);445-50. PMID 27050139 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Roemer FW, Aydemir A, Lohmander S, et al. Structural effects of sprifermin in knee osteoarthritis: a post-hoc analysis on cartilage and non-cartilaginous tissue alterations in a randomized controlled trial. BMC Musculoskelet Disord. 2016;17;267. PMID 27393009 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Yazici Y, McAlindon TE, Fleischmann R, et al. A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study. Osteoarthritis Cartilage. 2017;25(10);1598-1606. PMID 28711582 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Brett A, Bowes MA, Conaghan PG, et al. Automated MRI assessment confirms cartilage thickness modification in patients with knee osteoarthritis: post-hoc analysis from a phase II sprifermin study. Osteoarthritis Cartilage. 2020;28(11);1432-1436. PMID 32860991 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Conaghan PG, Bowes MA, Kingsbury SR, et al. Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized Controlled Trial. Ann Intern Med. 2020;172(2);86-95. PMID 31887743 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Roemer FW, Kraines J, Aydemir A, et al. Evaluating the structural effects of intra-articular sprifermin on cartilage and non-cartilaginous tissue alterations, based on sqMRI assessment over 2 years. Osteoarthritis Cartilage. 2020;28(9);1229-1234. PMID 32619609 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Eckstein F, Kraines JL, Aydemir A, et al. Intra-articular sprifermin reduces cartilage loss in addition to increasing cartilage gain independent of location in the femorotibial joint: post-hoc analysis of a randomised, placebo-controlled phase II clinical trial. Ann Rheum Dis. 2020;79(4);525-528. PMID 32098758 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Yazici Y, McAlindon TE, Gibofsky A, et al. Lorecivivint, a Novel Intraarticular CDC-like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial. Arthritis Rheumatol. 2020;72(10);1694-1706. PMID 32432388 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Yazici Y, McAlindon TE, Gibofsky A, et al. A Phase 2b randomized trial of lorecivivint, a novel intra-articular CLK2/DYRK1A inhibitor and Wnt pathway modulator for knee osteoarthritis. Osteoarthritis Cartilage. 2021;29(5);654-666. PMID 33588087 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Katz JN, Arant KR, Loeser RF. Diagnosis and Treatment of Hip and Knee Osteoarthritis: A Review. JAMA. 2021;325(6);568-578. PMID 33560326 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies, wiki/hip-osteoarthritis, wiki/overview
• Tambiah JRS, Kennedy S, Swearingen CJ, et al. Individual Participant Symptom Responses to Intra-Articular Lorecivivint in Knee Osteoarthritis: Post Hoc Analysis of a Phase 2B Trial. Rheumatol Ther. 2021;8(2);973-985. PMID 34101138 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Eckstein F, Hochberg MC, Guehring H, et al. Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study. Ann Rheum Dis. 2021;80(8);1062-1069. PMID 33962962 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Lv Z, Yang YX, Li J, et al. Molecular Classification of Knee Osteoarthritis. Front Cell Dev Biol. 2021;9;725568. PMID 34513847 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Guehring H, Moreau F, Daelken B, et al. The effects of sprifermin on symptoms and structure in a subgroup at risk of progression in the FORWARD knee osteoarthritis trial. Semin Arthritis Rheum. 2021;51(2);450-456. PMID 33752164 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Pye C, Bruniges N, Peffers M, et al. Advances in the pharmaceutical treatment options for canine osteoarthritis. J Small Anim Pract. 2022;63(10);721-738. PMID 35285032 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Tambiah JRS, Simsek I, Swearingen CJ, et al. Comparing Patient-Reported Outcomes From Sham and Saline-Based Placebo Injections for Knee Osteoarthritis: Data From a Randomized Clinical Trial of Lorecivivint. Am J Sports Med. 2022;50(3);630-636. PMID 35005990 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Lim YZ, Wang Y, Estee M, et al. Metformin as a potential disease-modifying drug in osteoarthritis: a systematic review of pre-clinical and human studies. Osteoarthritis Cartilage. 2022;30(11);1434-1442. PMID 35597372 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Oo WM. Prospects of Disease-Modifying Osteoarthritis Drugs. Clin Geriatr Med. 2022;38(2);397-432. PMID 35410687 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Zhou R, Fu W, Vasylyev D, et al. Ion channels in osteoarthritis: emerging roles and potential targets. Nat Rev Rheumatol. 2024;20(9);545-564. PMID 39122910 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Perruccio AV, Young JJ, Wilfong JM, et al. Osteoarthritis year in review 2023: Epidemiology & therapy. Osteoarthritis Cartilage. 2024;32(2);159-165. PMID 38035975 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Oo WM. Prospects of Disease-Modifying Osteoarthritis Drugs. Rheum Dis Clin North Am. 2024;50(3);483-518. PMID 38942581 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Eckstein F, Maschek S, Wirth W, et al. Unbiased analysis of knee cartilage thickness change over three years after sprifermin vs. placebo treatment - A post-hoc analysis from the phase 2B FORWARD study. Osteoarthr Cartil Open. 2024;6(4);100513. PMID 39286575 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Yazici Y, Tambiah JRS, Swearingen CJ, et al. A Phase 3, 28-week, multicentre, randomised, double-blind, placebo-controlled trial (OA-10) to evaluate the efficacy and safety of a single injection of lorecivivint in the target knee joint of moderately to severely symptomatic osteoarthritis patients. Clin Exp Rheumatol. 2025;43(5);847-853. PMID 39808288 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Yazici Y, Tambiah JRS, Swearingen CJ, et al. A Phase 3, 56-week, randomised, double-blind, placebo-controlled study (OA-11) utilising patient-reported and radiographic outcomes evaluating the efficacy and safety of a lorecivivint injection in patients with moderate to severe knee osteoarthritis. Clin Exp Rheumatol. 2025;43(5);854-860. PMID 39808286 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Conaghan PG, Katz N, Hunter DJ, et al. Exploring a novel outcome measure of symptom progression in knee osteoarthritis utilizing a large randomized trial. Osteoarthritis Cartilage. 2025;33(3);383-390. PMID 39734047 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies
• Shah SAA, Sachdev DS, Shahid ZUA, et al. Efficacy and safety of lorecivivint for the treatment of knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials. J Orthop Surg (Hong Kong). 2026;34(2);10225536261466342. PMID 42402776 — tags: [wiki-disease-modifying-therapies] — cited by: wiki/disease-modifying-therapies

Wiki — Epidemiology And Burden

• Dagenais S, Garbedian S, Wai EK. Systematic review of the prevalence of radiographic primary hip osteoarthritis. Clin Orthop Relat Res. 2009;467(3);623-37. PMID 19037710 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Silverwood V, Blagojevic-Bucknall M, Jinks C, et al. Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2015;23(4);507-15. PMID 25447976 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden, wiki/genetics-and-risk-factors
• Collins NJ, Prinsen CA, Christensen R, et al. Knee Injury and Osteoarthritis Outcome Score (KOOS): systematic review and meta-analysis of measurement properties. Osteoarthritis Cartilage. 2016;24(8);1317-29. PMID 27012756 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Alentorn-Geli E, Samuelsson K, Musahl V, et al. The Association of Recreational and Competitive Running With Hip and Knee Osteoarthritis: A Systematic Review and Meta-analysis. J Orthop Sports Phys Ther. 2017;47(6);373-390. PMID 28504066 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden, wiki/exercise-weight-and-self-management
• Madaleno FO, Santos BA, Araújo VL, et al. Prevalence of knee osteoarthritis in former athletes: a systematic review with meta-analysis. Braz J Phys Ther. 2018;22(6);437-451. PMID 29636304 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Heerey JJ, Kemp JL, Mosler AB, et al. What is the Prevalence of Hip Intra-Articular Pathologies and Osteoarthritis in Active Athletes with Hip and Groin Pain Compared with Those Without? A Systematic Review and Meta-Analysis. Sports Med. 2019;49(6);951-972. PMID 30972659 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Safari R, Jackson J, Sheffield D. Digital Self-Management Interventions for People With Osteoarthritis: Systematic Review With Meta-Analysis. J Med Internet Res. 2020;22(7);e15365. PMID 32706657 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Saueressig T, Owen PJ, Zebisch J, et al. Evaluation of Exercise Interventions and Outcomes After Hip Arthroplasty: A Systematic Review and Meta-analysis. JAMA Netw Open. 2021;4(2);e210254. PMID 33635329 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden, wiki/exercise-weight-and-self-management, wiki/hip-osteoarthritis
• Shi J, Fan K, Yan L, et al. Cost Effectiveness of Pharmacological Management for Osteoarthritis: A Systematic Review. Appl Health Econ Health Policy. 2022;20(3);351-370. PMID 35138600 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Young JJ, Jensen RK, Hartvigsen J, et al. Prevalence of multimorbid degenerative lumbar spinal stenosis with knee or hip osteoarthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2022;23(1);177. PMID 35209884 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Dong Y, Yan Y, Zhou J, et al. Evidence on risk factors for knee osteoarthritis in middle-older aged: a systematic review and meta analysis. J Orthop Surg Res. 2023;18(1);634. PMID 37641050 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden, wiki/genetics-and-risk-factors
• Wang HN, Luo P, Liu S, et al. Effectiveness of Internet-Based Telehealth Programs in Patients With Hip or Knee Osteoarthritis: Systematic Review and Meta-Analysis. J Med Internet Res. 2024;26;e55576. PMID 39348685 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Lawford BJ, Hall M, Hinman RS, et al. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2024;12(12);CD004376. PMID 39625083 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden, wiki/exercise-weight-and-self-management
• Jahn A, Andersen JH, Seidler A, et al. Hip osteoarthritis and occupational mechanical exposures: a systematic review and meta-analysis. Scand J Work Environ Health. 2024;50(4);244-256. PMID 38483209 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Wu R, Peng Q, Wang W, et al. Systematic review and network meta-analysis on the efficacy and safety of parmacotherapy for hand osteoarthritis. PLoS One. 2024;19(5);e0298774. PMID 38722915 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Pereira TV, Saadat P, Bobos P, et al. Effectiveness and safety of intra-articular interventions for knee and hip osteoarthritis based on large randomized trials: A systematic review and network meta-analysis. Osteoarthritis Cartilage. 2025;33(2);207-217. PMID 39265924 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden, wiki/injections-and-orthobiologics
• Kjeken I, Bordvik DH, Osteras N, et al. Efficacy and safety of non-pharmacological, pharmacological and surgical treatments for hand osteoarthritis in 2024: a systematic review. RMD Open. 2025;11(1);e004963. PMID 39793978 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden, wiki/guidelines
• Chen X, Shao C, Li L, et al. Prevalence of knee osteoarthritis in the Chinese population, 2013-2023: a systematic review and meta-analysis. J Orthop Surg Res. 2025;20(1);916. PMID 41121150 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Hsueh TY, Chen YP. The association between dyslipidemia and hand osteoarthritis: a systematic review and meta-analysis. Clin Rheumatol. 2025;44(4);1439-1448. PMID 40047991 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Somade OA, Shinde S, Thorat VM, et al. Physical Therapy-Based Realignment Strategies for Knee Osteoarthritis: A Systematic Review. Cureus. 2026;18(6);e110125. PMID 42395233 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Mathieu S, Rat AC, Sellam J. Prevalence and impact of sleep disorders in osteoarthritis: A systematic review and meta-analysis. Osteoarthr Cartil Open. 2026;8(1);100738. PMID 41550413 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Christofides I, Vavliakis I, de Klerk HH, et al. Prevalence of hip and knee osteoarthritis in Europe: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2026;27(1);155. PMID 41578252 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden
• Mathieu S, Fauchon C, Courties A, et al. Prevalence of neuropathic-like pain phenotype in people with hand osteoarthritis: A systematic literature review and meta-analysis. Joint Bone Spine. 2026;93(1);106012. PMID 41297581 — tags: [wiki-epidemiology-and-burden] — cited by: wiki/epidemiology-and-burden

Wiki — Exercise Weight And Self Management

• Fransen M, McConnell S, Harmer AR, et al. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2015;1(1);CD004376. PMID 25569281 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management, wiki/genetics-and-risk-factors
• Bartels EM, Juhl CB, Christensen R, et al. Aquatic exercise for the treatment of knee and hip osteoarthritis. Cochrane Database Syst Rev. 2016;3(3);CD005523. PMID 27007113 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management, wiki/hip-osteoarthritis
• Dong R, Wu Y, Xu S, et al. Is aquatic exercise more effective than land-based exercise for knee osteoarthritis? Medicine (Baltimore). 2018;97(52);e13823. PMID 30593178 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Munugoda IP, Beavers DP, Wirth W, et al. The effect of weight loss on the progression of meniscal extrusion and size in knee osteoarthritis: a post-hoc analysis of the Intensive Diet and Exercise for Arthritis (IDEA) trial. Osteoarthritis Cartilage. 2020;28(4);410-417. PMID 32014493 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Jiang X, Nelson AE, Cleveland RJ, et al. Precision Medicine Approach to Develop and Internally Validate Optimal Exercise and Weight-Loss Treatments for Overweight and Obese Adults With Knee Osteoarthritis: Data From a Single-Center Randomized Trial. Arthritis Care Res (Hoboken). 2021;73(5);693-701. PMID 32144896 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Luan L, Bousie J, Pranata A, et al. Stationary cycling exercise for knee osteoarthritis: A systematic review and meta-analysis. Clin Rehabil. 2021;35(4);522-533. PMID 33167714 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Bichsel D, Liechti FD, Schlapbach JM, et al. Cross-sectional Analysis of Recommendations for the Treatment of Hip and Knee Osteoarthritis in Clinical Guidelines. Arch Phys Med Rehabil. 2022;103(3);559-569.e5. PMID 34411512 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Sasaki R, Honda Y, Oga S, et al. Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: A systematic review with meta-analysis. PLoS One. 2022;17(11);e0275591. PMID 36409668 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management, wiki/hip-osteoarthritis
• Thomas DT, R S, Prabhakar AJ, et al. Hip abductor strengthening in patients diagnosed with knee osteoarthritis - a systematic review and meta-analysis. BMC Musculoskelet Disord. 2022;23(1);622. PMID 35768802 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Weng Q, Goh SL, Wu J, et al. Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials. Br J Sports Med. 2023;57(15);990-996. PMID 36593092 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management, wiki/hip-osteoarthritis, wiki/pharmacologic-treatment, wiki/red-flags-and-safety-concerns
• Mo L, Jiang B, Mei T, et al. Exercise Therapy for Knee Osteoarthritis: A Systematic Review and Network Meta-analysis. Orthop J Sports Med. 2023;11(5);23259671231172773. PMID 37346776 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management, wiki/genetics-and-risk-factors
• Holden MA, Hattle M, Runhaar J, et al. Moderators of the effect of therapeutic exercise for knee and hip osteoarthritis: a systematic review and individual participant data meta-analysis. Lancet Rheumatol. 2023;5(7);e386-e400. PMID 38251550 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Mao Y, Qiu B, Wang W, et al. Efficacy of home-based exercise in the treatment of pain and disability at the hip and knee in patients with osteoarthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2024;25(1);499. PMID 38926896 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management, wiki/hip-osteoarthritis
• Ding X, Yang Y, Xing Y, et al. Efficacy of lower limb strengthening exercises based on different muscle contraction characteristics for knee osteoarthritis: a systematic review and network meta-analysis. Front Med (Lausanne). 2024;11;1442683. PMID 39386751 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Somaiya KJ, Samal S, Boob MA. Physiotherapeutic Intervention Techniques for Knee Osteoarthritis: A Systematic Review. Cureus. 2024;16(3);e56817. PMID 38654798 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Welhaven HD, Welfley AH, Bothner B, et al. The metabolome of male and female individuals with knee osteoarthritis is influenced by 18-months of weight loss intervention: the IDEA trial. BMC Musculoskelet Disord. 2024;25(1);1057. PMID 39707277 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Yan L, Li D, Xing D, et al. Comparative efficacy and safety of exercise modalities in knee osteoarthritis: systematic review and network meta-analysis. BMJ. 2025;391;e085242. PMID 41093618 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Aftab S, Ali HN, Saeed B, et al. Early Physiotherapy for Post-Total Knee Arthroplasty Recovery: A Systematic Review of Randomized Controlled Trials on Quality of Life, Pain, and Range of Motion Outcomes. Musculoskeletal Care. 2025;23(3);e70158. PMID 40635148 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Hohmann E. Editorial Commentary: High-Platelet-Dose Platelet-Rich Plasma May Be the Nonoperative Treatment of Choice for Knee Osteoarthritis. Arthroscopy. 2025;41(3);818-820. PMID 38604391 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Liang Z, Wang C, Zhang M, et al. Optimal modality and dose of exercise for relieving pain in patients with knee or hip osteoarthritis: Bayesian pairwise, network, and dose-response meta-analyses. Semin Arthritis Rheum. 2025;75;152855. PMID 41124830 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Yang Y, Wang J, Wang T, et al. Optimal resistance training strategies for knee osteoarthritis symptom relief: a systematic review and network meta-analysis. BMC Musculoskelet Disord. 2025;27(1);48. PMID 41387830 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management
• Tian S, Liang Z, Yu Y, et al. Comparative Efficacy of Various Exercise Modalities and Doses in Reducing Pain and Improving Function in Older Adults With Knee or Hip Osteoarthritis: A Bayesian Network and Dose-Response Meta-analysis. Arch Phys Med Rehabil. 2026;107(4);784-796. PMID 40858208 — tags: [wiki-exercise-weight-and-self-management] — cited by: wiki/exercise-weight-and-self-management

Wiki — Genetics And Risk Factors

• Muthuri SG, Hui M, Doherty M, et al. What if we prevent obesity? Risk reduction in knee osteoarthritis estimated through a meta-analysis of observational studies. Arthritis Care Res (Hoboken). 2011;63(7);982-90. PMID 21425246 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Cross M, Smith E, Hoy D, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73(7);1323-30. PMID 24553908 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Rodriguez-Fontenla C, Gonzalez A. Genetics of osteoarthritis. Reumatol Clin. 2015;11(1);33-40. PMID 24992825 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Warner SC, Valdes AM. Genetic association studies in osteoarthritis: is it fairytale? Curr Opin Rheumatol. 2017;29(1);103-109. PMID 27755178 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Yau MS, Yerges-Armstrong LM, Liu Y, et al. Genome-Wide Association Study of Radiographic Knee Osteoarthritis in North American Caucasians. Arthritis Rheumatol. 2017;69(2);343-351. PMID 27696742 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Barowsky S, Jung JY, Nesbit N, et al. Cross-Disorder Genomics Data Analysis Elucidates a Shared Genetic Basis Between Major Depression and Osteoarthritis Pain. Front Genet. 2021;12;687687. PMID 34603368 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Cao Z, Wu Y, Li Q, et al. A causal relationship between childhood obesity and risk of osteoarthritis: results from a two-sample Mendelian randomization analysis. Ann Med. 2022;54(1);1636-1645. PMID 35703935 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Aubourg G, Rice SJ, Bruce-Wootton P, et al. Genetics of osteoarthritis. Osteoarthritis Cartilage. 2022;30(5);636-649. PMID 33722698 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors, wiki/overview
• Vasso M, Corona K, Gomberg B, et al. Obesity increases the risk of conversion to total knee arthroplasty after unicompartimental knee arthroplasty: a meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2022;30(12);3945-3957. PMID 34718836 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Whittaker JL, Losciale JM, Juhl CB, et al. Risk factors for knee osteoarthritis after traumatic knee injury: a systematic review and meta-analysis of randomised controlled trials and cohort studies for the OPTIKNEE Consensus. Br J Sports Med. 2022;56(24);1406-1421. PMID 36455966 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Zhang F, Rao S, Baranova A. Shared genetic liability between major depressive disorder and osteoarthritis. Bone Joint Res. 2022;11(1);12-22. PMID 35023758 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Faber BG, Frysz M, Boer CG, et al. The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses. EBioMedicine. 2023;95;104759. PMID 37619450 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Wu Q, Xu Z, Ma X, et al. Association of low muscle mass index and sarcopenic obesity with knee osteoarthritis: a systematic review and meta-analysis. J Int Soc Sports Nutr. 2024;21(1);2352393. PMID 38775452 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Wu Y, Hu H, Wang T, et al. Characterizing mitochondrial features in osteoarthritis through integrative multi-omics and machine learning analysis. Front Immunol. 2024;15;1414301. PMID 39026663 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Fu K, Si S, Jin X, et al. Exploring antidiabetic drug targets as potential disease-modifying agents in osteoarthritis. EBioMedicine. 2024;107;105285. PMID 39153411 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Liu J, Jin H, Yon DK, et al. Risk Factors for Depression in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis. Orthopedics. 2024;47(5);e225-e232. PMID 39208396 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Fan Y, Bian X, Meng X, et al. Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration. Ann Rheum Dis. 2024;83(7);926-944. PMID 38325908 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Zheng J, Sun Y, Liu W, et al. Genome-wide association assessment between immune cells and osteoarthritis: a bidirectional Mendelian randomization study. Ann Jt. 2025;10;22. PMID 40791899 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Hatzikotoulas K, Southam L, Stefansdottir L, et al. Translational genomics of osteoarthritis in 1,962,069 individuals. Nature. 2025;641(8065);1217-1224. PMID 40205036 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors
• Hatzikotoulas K, Southam L, Zeggini E. Genetics of osteoarthritis: Insights from GWAS to therapeutic opportunities. Osteoarthritis Cartilage. 2026;34(8);1153-1160. PMID 42128200 — tags: [wiki-genetics-and-risk-factors] — cited by: wiki/genetics-and-risk-factors

Wiki — Guidelines

• Jacobs JJ, Jevsevar DS, Brown GA, et al. AAOS Osteoarthritis Guideline: transparency and credibility. Arthroscopy. 2014;30(6);656-8. PMID 24862694 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Hauk L. Treatment of knee osteoarthritis: a clinical practice guideline from the AAOS. Am Fam Physician. 2014;89(11);918-20. PMID 25077402 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Giwnewer U, Rubin G, Orbach H, et al. [TREATMENT FOR OSTEOARTHRITIS OF THE KNEE]. Harefuah. 2016;155(7);403-406. PMID 28514128 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Scott J, Checketts JX, Horn JG, et al. "Knee osteoarthritis and current research for evidence-are we on the right way?". Int Orthop. 2018;42(9);2105-2112. PMID 29732493 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Manner PA, Tubb CC, Levine BR. AAOS Appropriate Use Criteria: Surgical Management of Osteoarthritis of the Knee. J Am Acad Orthop Surg. 2018;26(9);e194-e197. PMID 29621052 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Rheumatol. 2020;72(2);220-233. PMID 31908163 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Squiers M, Nelms NJ, Davis AT, et al. A Poster Summarizing the American Academy of Orthopaedic Surgeons Knee Osteoarthritis Clinical Practice Guideline Is a Powerful Tool for Patient Education: A Randomized Controlled Trial. J Arthroplasty. 2021;36(1);102-106.e5. PMID 32863075 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Dabbagh A, MacDermid JC. Appraisal of Clinical Practice Guideline: 2018 update of the EULAR recommendations for the management of hand osteoarthritis. J Physiother. 2021;67(1);68. PMID 32768184 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Kaur M, Black D, Fine J, et al. Referrals for physical therapy for osteoarthritis during the COVID-19 pandemic: A retrospective analysis. PLoS One. 2021;16(11);e0259679. PMID 34739521 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Leopold SS. Editorial: The New AAOS Guidelines on Knee Arthroscopy for Degenerative Meniscus Tears are a Step in the Wrong Direction. Clin Orthop Relat Res. 2022;480(1);1-3. PMID 34870953 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Anderson JM, Howard C, Staggs J, et al. Inadequate Reporting of Complications in Randomized Controlled Trials Cited as Supporting Evidence Underpinning AAOS CPG Recommendations for Hip and Knee Osteoarthritis: Application of the CONSORT Harms Checklist. J Arthroplasty. 2022;37(12);2466-2472.e2. PMID 35709908 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Fuggle N, Bere N, Bruyère O, et al. Management of hand osteoarthritis: from an US evidence-based medicine guideline to a European patient-centric approach. Aging Clin Exp Res. 2022;34(9);1985-1995. PMID 35864304 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Expert Panel on Musculoskeletal Imaging, Subhas N, Wu F, et al. ACR Appropriateness Criteria® Chronic Extremity Joint Pain-Suspected Inflammatory Arthritis, Crystalline Arthritis, or Erosive Osteoarthritis: 2022 Update. J Am Coll Radiol. 2023;20(5S);S20-S32. PMID 37236743 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Nelligan RK. Appraisal of Clinical Practice Guideline: National Institute for Health and Care Excellence (NICE) Clinical Practice Guideline for Osteoarthritis in over 16s: diagnosis and management. J Physiother. 2023;69(3);196. PMID 37263908 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Suh YS, Kim HO, Lee CH, et al. Correspondence on '2018 update of the EULAR recommendations for the management of hand osteoarthritis'. Ann Rheum Dis. 2023;82(9);e209. PMID 33082128 — tags: [wiki-guidelines] — cited by: wiki/guidelines
• Pi Z, He W, Lv X, et al. Comparative effectiveness of non-pharmacological interventions for knee osteoarthritis: protocol for a Bayesian Network meta-analysis. Syst Rev. 2025;15(1);11. PMID 41366780 — tags: [wiki-guidelines] — cited by: wiki/guidelines

Wiki — Hip Osteoarthritis

• Deyle GD, Henderson NE, Matekel RL, et al. Effectiveness of manual physical therapy and exercise in osteoarthritis of the knee. A randomized, controlled trial. Ann Intern Med. 2000;132(3);173-81. PMID 10651597 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Ganz R, Parvizi J, Beck M, et al. Femoroacetabular impingement: a cause for osteoarthritis of the hip. Clin Orthop Relat Res. 2003;(417);112-20. PMID 14646708 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Hoeksma HL, Dekker J, Ronday HK, et al. Comparison of manual therapy and exercise therapy in osteoarthritis of the hip: a randomized clinical trial. Arthritis Rheum. 2004;51(5);722-9. PMID 15478147 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Petis S, Howard JL, Lanting BL, et al. Surgical approach in primary total hip arthroplasty: anatomy, technique and clinical outcomes. Can J Surg. 2015;58(2);128-39. PMID 25799249 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Gala L, Clohisy JC, Beaulé PE. Hip Dysplasia in the Young Adult. J Bone Joint Surg Am. 2016;98(1);63-73. PMID 26738905 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Hofstede SN, Gademan MG, Vliet Vlieland TP, et al. Preoperative predictors for outcomes after total hip replacement in patients with osteoarthritis: a systematic review. BMC Musculoskelet Disord. 2016;17;212. PMID 27184266 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Dias JM, Cisneros L, Dias R, et al. Hydrotherapy improves pain and function in older women with knee osteoarthritis: a randomized controlled trial. Braz J Phys Ther. 2017;21(6);449-456. PMID 28733093 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Lespasio MJ, Sultan AA, Piuzzi NS, et al. Hip Osteoarthritis: A Primer. Perm J. 2018;22;17-084. PMID 29309269 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Goh SL, Persson MSM, Stocks J, et al. Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: A systematic review and meta-analysis. Ann Phys Rehabil Med. 2019;62(5);356-365. PMID 31121333 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Yuenyongviwat V, Duangmanee S, Iamthanaporn K, et al. Effect of hip abductor strengthening exercises in knee osteoarthritis: a randomized controlled trial. BMC Musculoskelet Disord. 2020;21(1);284. PMID 32380994 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Günther KP, Deckert S, Lützner C, et al. Total Hip Replacement for Osteoarthritis-Evidence-Based and Patient-Oriented Indications. Dtsch Arztebl Int. 2021;118(43);730-736. PMID 34693905 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Hall M, van der Esch M, Hinman RS, et al. How does hip osteoarthritis differ from knee osteoarthritis? Osteoarthritis Cartilage. 2022;30(1);32-41. PMID 34600121 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Runge N, Aina A, May S. The Benefits of Adding Manual Therapy to Exercise Therapy for Improving Pain and Function in Patients With Knee or Hip Osteoarthritis: A Systematic Review With Meta-analysis. J Orthop Sports Phys Ther. 2022;52(10);675-A13. PMID 35881705 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Salman LA, Hantouly AT, Khatkar H, et al. The outcomes of total hip replacement in osteonecrosis versus osteoarthritis: a systematic review and meta-analysis. Int Orthop. 2023;47(12);3043-3052. PMID 36905418 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis, wiki/surgery-and-joint-replacement
• Chen G, Yu D, Wang Y, et al. A Prospective Randomized Controlled Trial Assessing the Impact of Preoperative Combined with Postoperative Progressive Resistance Training on Muscle Strength, Gait, Balance and Function in Patients Undergoing Total Hip Arthroplasty. Clin Interv Aging. 2024;19;745-760. PMID 38736563 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Funahashi H, Osawa Y, Takegami Y, et al. Acetabular osteophyte formation in dysplastic hip osteoarthritis. BMC Musculoskelet Disord. 2024;25(1);1072. PMID 39725945 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Kjeldsen T, Skou ST, Dalgas U, et al. Progressive Resistance Training or Neuromuscular Exercise for Hip Osteoarthritis : A Multicenter Cluster Randomized Controlled Trial. Ann Intern Med. 2024;177(5);573-582. PMID 38588540 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Frydendal T, Christensen R, Mechlenburg I, et al. Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis. N Engl J Med. 2024;391(17);1610-1620. PMID 39476341 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Loke RWK, Lim YH, Chan YK, et al. MAKO robotic-assisted compared to conventional total hip arthroplasty for hip osteoarthritis: a systematic review and meta-analysis. J Orthop Surg Res. 2025;20(1);466. PMID 40380310 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis, wiki/surgery-and-joint-replacement
• Honvo G, Lengelé L, Alokail M, et al. Safety of Anti-osteoarthritis Medications: A Systematic Literature Review of Post-marketing Surveillance Studies. Drugs. 2025;85(4);505-555. PMID 40095377 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis
• Young JJ, Zywiel MG, Skou ST, et al. Total Hip Arthroplasty versus Education and Exercise: A Secondary Analysis of Propensity Matched Data Comparing Outcomes Across Hip Osteoarthritis Symptom Severity. J Arthroplasty. 2025;40(9 Suppl 1);S246-S252. PMID 40841100 — tags: [wiki-hip-osteoarthritis] — cited by: wiki/hip-osteoarthritis

Wiki — Injections And Orthobiologics

• Wang CT, Lin J, Chang CJ, et al. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials. J Bone Joint Surg Am. 2004;86(3);538-45. PMID 14996880 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics, wiki/pharmacologic-treatment
• Bannuru RR, Schmid CH, Kent DM, et al. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162(1);46-54. PMID 25560713 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics, wiki/pharmacologic-treatment
• Henricsdotter C, Ellegaard K, Klokker L, et al. Changes in ultrasound assessed markers of inflammation following intra-articular steroid injection combined with exercise in knee osteoarthritis: exploratory outcome from a randomized trial. Osteoarthritis Cartilage. 2016;24(5);814-21. PMID 26746147 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Bannuru RR, Osani M, Vaysbrot EE, et al. Comparative safety profile of hyaluronic acid products for knee osteoarthritis: a systematic review and network meta-analysis. Osteoarthritis Cartilage. 2016;24(12);2022-2041. PMID 27492466 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Xing D, Wang B, Liu Q, et al. Intra-articular Hyaluronic Acid in Treating Knee Osteoarthritis: a PRISMA-Compliant Systematic Review of Overlapping Meta-analysis. Sci Rep. 2016;6;32790. PMID 27616273 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Bisicchia S, Tudisco C. Hyaluronic acid vs corticosteroids in symptomatic knee osteoarthritis: a mini-review of the literature. Clin Cases Miner Bone Metab. 2017;14(2);182-185. PMID 29263730 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Paterson KL, Hunter DJ, Metcalf BR, et al. Efficacy of intra-articular injections of platelet-rich plasma as a symptom- and disease-modifying treatment for knee osteoarthritis - the RESTORE trial protocol. BMC Musculoskelet Disord. 2018;19(1);272. PMID 30055602 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Nielsen FK, Boesen M, Jurik AG, et al. The effect of intra-articular glucocorticosteroids and exercise on symptoms and bone marrow lesions in knee osteoarthritis: a secondary analysis of results from a randomized controlled trial. Osteoarthritis Cartilage. 2018;26(7);895-902. PMID 29499289 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Paik J, Duggan ST, Keam SJ. Triamcinolone Acetonide Extended-Release: A Review in Osteoarthritis Pain of the Knee. Drugs. 2019;79(4);455-462. PMID 30847805 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Zhao D, Pan JK, Yang WY, et al. Intra-Articular Injections of Platelet-Rich Plasma, Adipose Mesenchymal Stem Cells, and Bone Marrow Mesenchymal Stem Cells Associated With Better Outcomes Than Hyaluronic Acid and Saline in Knee Osteoarthritis: A Systematic Review and Network Meta-analysis. Arthroscopy. 2021;37(7);2298-2314.e10. PMID 33713757 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Anil U, Markus DH, Hurley ET, et al. The efficacy of intra-articular injections in the treatment of knee osteoarthritis: A network meta-analysis of randomized controlled trials. Knee. 2021;32;173-182. PMID 34500430 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Manchikanti L, Atluri S, Hirsch JA. Comment on "Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients with Knee Osteoarthritis: The Restore Randomized Clinical Trial". Pain Physician. 2022;25(4);E698. PMID 35793195 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Donovan RL, Edwards TA, Judge A, et al. Effects of recurrent intra-articular corticosteroid injections for osteoarthritis at 3 months and beyond: a systematic review and meta-analysis in comparison to other injectables. Osteoarthritis Cartilage. 2022;30(12);1658-1669. PMID 36108937 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Li Y, Mai Y, Cao P, et al. Relative Efficacy and Safety of Anti-Inflammatory Biologic Agents for Osteoarthritis: A Conventional and Network Meta-Analysis. J Clin Med. 2022;11(14);3958. PMID 35887724 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Yu SP, Ferreira ML, Duong V, et al. Responsiveness of an activity tracker as a measurement tool in a knee osteoarthritis clinical trial (ACTIVe-OA study). Ann Phys Rehabil Med. 2022;65(5);101619. PMID 34879312 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Liao CD, Chen HC, Huang MH, et al. Comparative Efficacy of Intra-Articular Injection, Physical Therapy, and Combined Treatments on Pain, Function, and Sarcopenia Indices in Knee Osteoarthritis: A Network Meta-Analysis of Randomized Controlled Trials. Int J Mol Sci. 2023;24(7);6078. PMID 37047058 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Zhang Y, Ruan G, Zheng P, et al. Efficacy and safety of GLucocorticoid injections into InfrapaTellar faT pad in patients with knee ostEoarthRitiS: protocol for the GLITTERS randomized controlled trial. Trials. 2023;24(1);6. PMID 36597103 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Qiao X, Yan L, Feng Y, et al. Efficacy and safety of corticosteroids, hyaluronic acid, and PRP and combination therapy for knee osteoarthritis: a systematic review and network meta-analysis. BMC Musculoskelet Disord. 2023;24(1);926. PMID 38037038 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Sullivan JK, Gottreich JR, Imrey PB, et al. The Corticosteroid Meniscectomy Trial of Extended-Release Triamcinolone Injection After Arthroscopic Partial Meniscectomy: Protocol for a Double-Blind Randomized Controlled Trial. Orthop J Sports Med. 2023;11(4);23259671231150812. PMID 37113139 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Tschopp M, Pfirrmann CWA, Brunner F, et al. Morphological and Quantitative Parametric MRI Follow-up of Cartilage Changes Before and After Intra-articular Injection Therapy in Patients With Mild to Moderate Knee Osteoarthritis: A Randomized, Placebo-Controlled Trial. Invest Radiol. 2024;59(9);646-655. PMID 38421679 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Loke RYJ, Chu Z, Liang J, et al. Allogenic MSCs are a safe and efficacious treatment for knee osteoarthritis: A systematic review of randomised controlled trials. J Exp Orthop. 2025;12(3);e70437. PMID 40980258 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Nawaz HMT, Jawwad MA, Khan MU, et al. Efficacy of Platelet-Rich Plasma Injections in Knee Osteoarthritis: A Systematic Review and Meta-Analysis. Cureus. 2025;17(10);e94288. PMID 41216044 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Whittle SL, Johnston RV, McDonald S, et al. Stem cell injections for osteoarthritis of the knee. Cochrane Database Syst Rev. 2025;4(4);CD013342. PMID 40169165 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics, wiki/pharmacologic-treatment, wiki/red-flags-and-safety-concerns
• Zhang Y, Ruan G, Fan T, et al. Infrapatellar Fat Pad Glucocorticoid Injection in Knee Osteoarthritis: A Randomized Clinical Trial. JAMA Netw Open. 2026;9(1);e2549938. PMID 41481293 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Batista JD, Silva LD, Batista JD, et al. Intra-articular adipose-derived cell therapies for knee osteoarthritis: a systematic review of randomized controlled trials. Front Med (Lausanne). 2026;13;1771008. PMID 42100287 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics
• Xu B, Huang X, Su X, et al. Leukocyte-rich versus leukocyte-poor platelet-rich plasma and hyaluronic acid for knee osteoarthritis: a systematic review and network meta-analysis. J Orthop Surg Res. 2026;21(1);222. PMID 41629990 — tags: [wiki-injections-and-orthobiologics] — cited by: wiki/injections-and-orthobiologics

Wiki — Knee Osteoarthritis

• Brouwer RW, van Raaij TM, Verhaar JA, et al. Brace treatment for osteoarthritis of the knee: a prospective randomized multi-centre trial. Osteoarthritis Cartilage. 2006;14(8);777-83. PMID 16563810 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Beaudreuil J, Bendaya S, Faucher M, et al. Clinical practice guidelines for rest orthosis, knee sleeves, and unloading knee braces in knee osteoarthritis. Joint Bone Spine. 2009;76(6);629-36. PMID 19467901 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Tsoukas D, Fotopoulos V, Basdekis G, et al. No difference in osteoarthritis after surgical and non-surgical treatment of ACL-injured knees after 10 years. Knee Surg Sports Traumatol Arthrosc. 2016;24(9);2953-2959. PMID 25854500 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Chesham RA, Shanmugam S. Does preoperative physiotherapy improve postoperative, patient-based outcomes in older adults who have undergone total knee arthroplasty? A systematic review. Physiother Theory Pract. 2017;33(1);9-30. PMID 27736286 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis, wiki/surgery-and-joint-replacement
• Cao Z, Mai X, Wang J, et al. Unicompartmental Knee Arthroplasty vs High Tibial Osteotomy for Knee Osteoarthritis: A Systematic Review and Meta-Analysis. J Arthroplasty. 2018;33(3);952-959. PMID 29203354 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Faucett SC, Geisler BP, Chahla J, et al. Meniscus Root Repair vs Meniscectomy or Nonoperative Management to Prevent Knee Osteoarthritis After Medial Meniscus Root Tears: Clinical and Economic Effectiveness. Am J Sports Med. 2019;47(3);762-769. PMID 29517925 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis, wiki/surgery-and-joint-replacement
• Petersen W, Ellermann A, Henning J, et al. Non-operative treatment of unicompartmental osteoarthritis of the knee: a prospective randomized trial with two different braces-ankle-foot orthosis versus knee unloader brace. Arch Orthop Trauma Surg. 2019;139(2);155-166. PMID 30255369 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Robert-Lachaine X, Dessery Y, Belzile ÉL, et al. Three-month efficacy of three knee braces in the treatment of medial knee osteoarthritis in a randomized crossover trial. J Orthop Res. 2020;38(10);2262-2271. PMID 32077519 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Gueugnon M, Fournel I, Soilly AL, et al. Effectiveness, safety, and cost-utility of a knee brace in medial knee osteoarthritis: the ERGONOMIE randomized controlled trial. Osteoarthritis Cartilage. 2021;29(4);491-501. PMID 33524515 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Moller F, Ortíz-Muñoz L, Irarrázaval S. Offloader knee braces for knee osteoarthritis. Medwave. 2021;21(3);e8115. PMID 34038401 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• He M, Zhong X, Li Z, et al. Progress in the treatment of knee osteoarthritis with high tibial osteotomy: a systematic review. Syst Rev. 2021;10(1);56. PMID 33583421 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Huang XM, Yuan FZ, Chen YR, et al. Physical therapy and orthopaedic equipment-induced reduction in the biomechanical risk factors related to knee osteoarthritis: a systematic review and Bayesian network meta-analysis of randomised controlled trials. BMJ Open. 2022;12(2);e051608. PMID 35140149 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Wu ZX, Ren WX, Wang ZQ. Proximal fibular osteotomy versus high tibial osteotomy for treating knee osteoarthritis: a systematic review and meta-analysis. J Orthop Surg Res. 2022;17(1);470. PMID 36307827 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Xie T, Brouwer RW, van den Akker-Scheek I, et al. Clinical relevance of joint line obliquity after high tibial osteotomy for medial knee osteoarthritis remains controversial: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2023;31(10);4355-4367. PMID 37340220 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Marriott KA, Birmingham TB. Fundamentals of osteoarthritis. Rehabilitation: Exercise, diet, biomechanics, and physical therapist-delivered interventions. Osteoarthritis Cartilage. 2023;31(10);1312-1326. PMID 37423596 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Marshall DA, Trenaman L, MacDonald KV, et al. Impact of an online, individualised, patient reported outcome measures based patient decision aid on patient expectations, decisional regret, satisfaction, and health-related quality-of-life for patients considering total knee arthroplasty: Results from a randomised controlled trial. J Eval Clin Pract. 2023;29(3);513-524. PMID 36575631 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis, wiki/surgery-and-joint-replacement
• Kurien T, East J, Mandalia V. The effects of open wedge high tibial osteotomy for knee osteoarthritis on the patellofemoral joint. A systematic review. Knee. 2023;40;201-219. PMID 36512892 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Zhang B, Qian H, Wu H, et al. Unicompartmental knee arthroplasty versus high tibial osteotomy for medial knee osteoarthritis: A systematic review and meta-analysis. J Orthop Surg (Hong Kong). 2023;31(1);10225536231162829. PMID 36893443 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Harvey J, Eltayeb M, Moulder EH, et al. Compensatory mechanisms for proximal & distal joint alignment & gait in varus knee osteoarthritis treated with high tibial osteotomy: A systematic review. J Orthop. 2024;54;148-157. PMID 38586600 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Zhang W, Ma Y, Lu F, et al. Efficacy and safety of high tibial osteotomy combined with platelet-rich plasma for treating knee osteoarthritis: a systematic review and meta-analysis of the Chinese population. BMC Musculoskelet Disord. 2024;25(1);876. PMID 39487422 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Dal Fabbro G, Grassi A, Agostinone P, et al. High survivorship rate and good clinical outcomes after high tibial osteotomy in patients with radiological advanced medial knee osteoarthritis: a systematic review. Arch Orthop Trauma Surg. 2024;144(9);3977-3988. PMID 38430233 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Rogoschin J, Komnik I, Potthast W. Neuromuscular Adaptations Related to Medial Knee Osteoarthritis and Influence of Unloader Braces on Neuromuscular Activity in Knee Osteoarthritis Subjects-A Systematic Review. Am J Phys Med Rehabil. 2024;103(11);1051-1059. PMID 38709674 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Chen X, Fan Y, Tu H, et al. Clinical efficacy of different therapeutic options for knee osteoarthritis: A network meta-analysis based on randomized clinical trials. PLoS One. 2025;20(6);e0324864. PMID 40531843 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Vosoughi F, Vahedi P, Nakhjiri MT, et al. High tibial osteotomy and concurrent medial meniscus root repair provides improved objective outcomes compared to high tibial osteotomy alone for knee osteoarthritis: A systematic review. Knee Surg Sports Traumatol Arthrosc. 2025;33(9);3361-3374. PMID 40679279 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Liu H, Qin L, Liu Y, et al. Knee osteoarthritis rehabilitation: an integrated framework of exercise, nutrition, biomechanics, and physical therapist guidance-a narrative review. Eur J Med Res. 2025;30(1);826. PMID 40887656 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Cortina G, Antuofermo SM, Papalia GF, et al. Limited clinical benefit of medial meniscus posterior root repair combined with high tibial osteotomy in varus knee osteoarthritis: A systematic review and meta-analysis. J Exp Orthop. 2025;12(3);e70431. PMID 40989938 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Stam M, Verschueren J, Van Outeren MV, et al. Unloader brace or high tibial osteotomy in the treatment of the young patient with medial knee osteoarthritis: a randomized controlled trial. Acta Orthop. 2025;96;102-109. PMID 39832288 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis
• Pacheco-Brousseau L, Abdelrazeq S, Kelly SE, et al. Total and partial knee arthroplasty versus non-surgical interventions of the knee for moderate to severe osteoarthritis. Cochrane Database Syst Rev. 2026;1(1);CD015378. PMID 41494148 — tags: [wiki-knee-osteoarthritis] — cited by: wiki/knee-osteoarthritis, wiki/surgery-and-joint-replacement

Wiki — Overview

• Krebs EE, Gravely A, Nugent S, et al. Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial. JAMA. 2018;319(9);872-882. PMID 29509867 — tags: [wiki-overview] — cited by: wiki/overview
• Primorac D, Molnar V, Rod E, et al. Knee Osteoarthritis: A Review of Pathogenesis and State-Of-The-Art Non-Operative Therapeutic Considerations. Genes (Basel). 2020;11(8);854. PMID 32722615 — tags: [wiki-overview] — cited by: wiki/overview

Wiki — Pain Mechanisms And Sensitization

• Dimitroulas T, Duarte RV, Behura A, et al. Neuropathic pain in osteoarthritis: a review of pathophysiological mechanisms and implications for treatment. Semin Arthritis Rheum. 2014;44(2);145-54. PMID 24928208 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Perrot S. Osteoarthritis pain. Best Pract Res Clin Rheumatol. 2015;29(1);90-7. PMID 26267003 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• O'Neill TW, Felson DT. Mechanisms of Osteoarthritis (OA) Pain. Curr Osteoporos Rep. 2018;16(5);611-616. PMID 30155845 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Syx D, Tran PB, Miller RE, et al. Peripheral Mechanisms Contributing to Osteoarthritis Pain. Curr Rheumatol Rep. 2018;20(2);9. PMID 29480410 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Vincent TL. Peripheral pain mechanisms in osteoarthritis. Pain. 2020;161 Suppl 1(1);S138-S146. PMID 33090747 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Sandhar S, Smith TO, Toor K, et al. Risk factors for pain and functional impairment in people with knee and hip osteoarthritis: a systematic review and meta-analysis. BMJ Open. 2020;10(8);e038720. PMID 32771991 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Nairn LN, Subramaniam M, Ekhtiari S, et al. Safety and early results of Subchondroplasty® for the treatment of bone marrow lesions in osteoarthritis: a systematic review. Knee Surg Sports Traumatol Arthrosc. 2021;29(11);3599-3607. PMID 32990774 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Obotiba AD, Swain S, Kaur J, et al. Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies. Osteoarthritis Cartilage. 2021;29(7);946-955. PMID 33895290 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Leaney AA, Lyttle JR, Segan J, et al. Antidepressants for hip and knee osteoarthritis. Cochrane Database Syst Rev. 2022;10(10);CD012157. PMID 36269595 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Kleinschmidt AC, Singh A, Hussain S, et al. How Effective Are Non-Operative Intra-Articular Treatments for Bone Marrow Lesions in Knee Osteoarthritis in Adults? A Systematic Review of Controlled Clinical Trials. Pharmaceuticals (Basel). 2022;15(12);1555. PMID 36559005 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Coaccioli S, Sarzi-Puttini P, Zis P, et al. Osteoarthritis: New Insight on Its Pathophysiology. J Clin Med. 2022;11(20);6013. PMID 36294334 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Tran Y, Pelletier-Roy R, Merle G, et al. Subchondroplasty in the treatment of bone Marrow lesion in early Knee Osteoarthritis: A systematic review of clinical and radiological outcomes. Knee. 2022;39;279-290. PMID 36332558 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Solanki P, Hussain SM, Abidi J, et al. Association between weight gain and knee osteoarthritis: a systematic review. Osteoarthritis Cartilage. 2023;31(3);300-316. PMID 36511280 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Dainese P, Mahieu H, De Mits S, et al. Associations between markers of inflammation and altered pain perception mechanisms in people with knee osteoarthritis: a systematic review. RMD Open. 2023;9(2);e002945. PMID 37225282 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Ohashi Y, Uchida K, Fukushima K, et al. Mechanisms of Peripheral and Central Sensitization in Osteoarthritis Pain. Cureus. 2023;15(2);e35331. PMID 36846635 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Fang H, Zhang X, Wang J, et al. The relationship between MRI-detected hip abnormalities and hip pain in hip osteoarthritis: a systematic review. Rheumatol Int. 2024;44(10);1887-1896. PMID 39136786 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Binvignat M, Sellam J, Berenbaum F, et al. The role of obesity and adipose tissue dysfunction in osteoarthritis pain. Nat Rev Rheumatol. 2024;20(9);565-584. PMID 39112603 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Rodríguez-Lagos L, Fernández-Carnero J, Laguarta-Val S, et al. Conditioned pain modulation and temporal summation in patients with knee osteoarthritis: A systematic review and meta-analysis. J Pain. 2025;33;105464. PMID 40517980 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Gonzalez FF, Barone A, Palaniappan R, et al. Preoperative neuropathic-like pain and central sensitisation are risk factors for chronic pain after total knee arthroplasty: A systematic review and meta-analysis. Osteoarthr Cartil Open. 2025;7(4);100674. PMID 40995335 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Huang K, Cai H. Mechanisms of pain occurrence in osteoarthritis: peripheral triggers, sensitization, and the path to persistence. Front Immunol. 2026;17;1820875. PMID 42433364 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Klincke V, Demoor B, Dehouwer F, et al. Subchondroplasty for bone-marrow lesions in the osteoarthritic knee improves pain and function: a systematic review and meta-analysis. Knee. 2026;61;104441. PMID 41950892 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Kow CS, Ramachandram DS, Thiruchelvam K. The effect of pregabalin on pain and function in knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Inflammopharmacology. 2026;10.1007/s10787-026-02344-w. PMID 42481863 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization
• Shangguan Y, Zhou Z, Liu K, et al. Transcranial direct current stimulation for pain threshold in knee osteoarthritis: a mechanism-oriented systematic review and meta-analysis of randomized controlled trials. Front Physiol. 2026;17;1890510. PMID 42523626 — tags: [wiki-pain-mechanisms-and-sensitization] — cited by: wiki/pain-mechanisms-and-sensitization

Wiki — Patient Experience And Advocacy

• Snoeker BA, Bakker EW, Kegel CA, et al. Risk factors for meniscal tears: a systematic review including meta-analysis. J Orthop Sports Phys Ther. 2013;43(6);352-67. PMID 23628788 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy
• Wellsandt E, Golightly Y. Exercise in the management of knee and hip osteoarthritis. Curr Opin Rheumatol. 2018;30(2);151-159. PMID 29251659 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy
• McGruer N, Baldwin JN, Ruakere BT, et al. Māori lived experience of osteoarthritis: a qualitative study guided by Kaupapa Māori principles. J Prim Health Care. 2019;11(2);128-137. PMID 32171355 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy
• Milić M, Nonković M, Buterin A, et al. Informed Patient Is Satisfied Patient - Qualitative Study of Patients' Experience after Total Hip Arthroplasty. Psychiatr Danub. 2021;33(Suppl 4);1303-1308. PMID 35503946 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy
• Harris AB, Oni JK. Cementless, Cruciate-Retaining Primary Total Knee Arthroplasty Using Conventional Instrumentation: Technical Pearls and Intraoperative Considerations. JBJS Essent Surg Tech. 2024;14(3);e23.00036. PMID 39280965 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy
• Gibbs AJ, Barton CJ, Taylor NF, et al. General practitioners experience multi-level barriers to implementing recommended care for hip and knee osteoarthritis: a qualitative study. BMC Prim Care. 2024;25(1);423. PMID 39702012 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy
• Caneiro JP, O'Sullivan P, Tan JS, et al. Process of change for people with knee osteoarthritis undergoing cognitive functional therapy: a replicated single-case experimental design study. Disabil Rehabil. 2024;46(11);2348-2364. PMID 37317550 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy
• Kloppenburg M, Namane M, Cicuttini F. Osteoarthritis. Lancet. 2025;405(10472);71-85. PMID 39755397 — tags: [overview, DMOAD, wiki-patient-experience-and-advocacy] — cited by: OPEN-QUESTIONS.md, wiki/overview, wiki/patient-experience-and-advocacy
• Zhao G, Ma C, Ma J, et al. Patient perceptions regarding ambulatory knee arthroplasties in China. Arthroplasty. 2025;7(1);28. PMID 40484958 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy
• Babatunde OO, Adetunji O, Alonge I, et al. Process and feasibility of implementing guideline recommendations for the care of osteoarthritis in West Africa. BMJ Glob Health. 2025;10(6);e018714. PMID 40537272 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy
• Whitehouse MR, Judge A, Hawley S, et al. RecUrrent Intra-articular Corticosteroid injections in Osteoarthritis: the RUbICOn mixed-methods study. Health Technol Assess. 2025;29(56);1-167. PMID 41217479 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy
• Anombem OM, Oliver JE, Kilmer J, et al. Comparing the Effectiveness of Radiofrequency Ablation and Intra-articular Steroid Injections in the Management of Knee Osteoarthritis: A Systematic Review. Cureus. 2026;18(3);e104652. PMID 41939559 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy
• Zhan YF, Yang L, Zhang SZ, et al. Experience of patients with total knee arthroplasty for knee osteoarthritis in China: a patient journey map based on qualitative research. BMJ Open. 2026;16(3);e104740. PMID 41857856 — tags: [wiki-patient-experience-and-advocacy] — cited by: wiki/patient-experience-and-advocacy

Wiki — Pharmacologic Treatment

• Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008;16(2);137-62. PMID 18279766 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Xing RL, Zhao LR, Wang PM. Bisphosphonates therapy for osteoarthritis: a meta-analysis of randomized controlled trials. Springerplus. 2016;5(1);1704. PMID 27757376 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• da Costa BR, Reichenbach S, Keller N, et al. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet. 2017;390(10090);e21-e33. PMID 28699595 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Vaysbrot EE, Osani MC, Musetti MC, et al. Are bisphosphonates efficacious in knee osteoarthritis? A meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2018;26(2);154-164. PMID 29222056 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Zeng C, Wei J, Persson MSM, et al. Relative efficacy and safety of topical non-steroidal anti-inflammatory drugs for osteoarthritis: a systematic review and network meta-analysis of randomised controlled trials and observational studies. Br J Sports Med. 2018;52(10);642-650. PMID 29436380 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Meng Z, Huang R. Topical Treatment of Degenerative Knee Osteoarthritis. Am J Med Sci. 2018;355(1);6-12. PMID 29289264 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Rodriguez-Merchan EC. Topical therapies for knee osteoarthritis. Postgrad Med. 2018;130(7);607-612. PMID 30156934 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Osani MC, Bannuru RR. Efficacy and safety of duloxetine in osteoarthritis: a systematic review and meta-analysis. Korean J Intern Med. 2019;34(5);966-973. PMID 30871298 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Chen L, Gong M, Liu G, et al. Efficacy and tolerability of duloxetine in patients with knee osteoarthritis: a meta-analysis of randomised controlled trials. Intern Med J. 2019;49(12);1514-1523. PMID 30993832 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Gao SH, Huo JB, Pan QM, et al. The short-term effect and safety of duloxetine in osteoarthritis: A systematic review and meta-analysis. Medicine (Baltimore). 2019;98(44);e17541. PMID 31689755 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Chen B, Duan J, Wen S, et al. An Updated Systematic Review and Meta-analysis of Duloxetine for Knee Osteoarthritis Pain. Clin J Pain. 2021;37(11);852-862. PMID 34483232 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Liu CY, Duan YS, Zhou H, et al. Clinical effect and contributing factors of acupuncture for knee osteoarthritis: a systematic review and pairwise and exploratory network meta-analysis. BMJ Evid Based Med. 2024;29(6);374-384. PMID 39486882 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Zhong H, Li J, Chen Y, et al. Effect of duloxetine on pain and opioid consumption after total knee and hip arthroplasty: a systematic review and meta-analysis of randomized controlled trials. Int J Clin Pharm. 2024;46(1);14-25. PMID 37294475 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Zhao J, Liang G, Zhou G, et al. Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis. J Ethnopharmacol. 2024;321;117493. PMID 38036015 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Sethi V, Qin L, Cox E, et al. Model-Based Meta-Analysis Supporting the Combination of Acetaminophen and Topical Diclofenac in Acute Pain: A Therapy for Mild-to-Moderate Osteoarthritis Pain? Pain Ther. 2024;13(1);145-159. PMID 38183573 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Cao Z, Han K, Lu H, et al. Paracetamol Combination Therapy for Back Pain and Osteoarthritis: A Systematic Review and Meta-Analyses. Drugs. 2024;84(8);953-967. PMID 38937394 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment, wiki/red-flags-and-safety-concerns
• JiaoYi P, YongQi S, KeChun G, et al. Assessing the efficacy and safety of different nonsteroidal anti-inflammatory drugs in the treatment of osteoarthritis: A systematic review and network meta-analysis based on RCT trials. PLoS One. 2025;20(5);e0320379. PMID 40333622 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment, wiki/red-flags-and-safety-concerns
• Zhang Y, Gui Y, Adams R, et al. Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis. Nutrients. 2025;17(15);2547. PMID 40806131 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment, wiki/red-flags-and-safety-concerns
• Wai HS, Pathomwichaiwat T, Suansanae T, et al. Effect of turmeric products on knee osteoarthritis: a systematic review and network meta-analysis. BMC Complement Med Ther. 2025;25(1);292. PMID 40731001 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment
• Chen ZR, Chen BK, Li P, et al. Efficacy and safety of different topical diclofenac formulations for the treatment of knee osteoarthritis: a meta-analysis of short-term and long-term treatment comparisons. BMC Musculoskelet Disord. 2025;26(1);230. PMID 40065343 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment, wiki/red-flags-and-safety-concerns
• Bhandari B, Bisht K, Purohit G, et al. Navigating the Efficacy and Safety Landscape of Duloxetine in Osteoarthritis Management: A Meta-Analysis of Randomized Controlled Trials. Indian J Orthop. 2025;59(8);1123-1136. PMID 40852552 — tags: [wiki-pharmacologic-treatment] — cited by: wiki/pharmacologic-treatment

Wiki — Red Flags And Safety Concerns

• Batra S, Batra M, McMurtrie A, et al. Rapidly destructive osteoarthritis of the hip joint: a case series. J Orthop Surg Res. 2008;3;3. PMID 18190689 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Bartels EM, Bliddal H, Schøndorff PK, et al. Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta-analysis of randomized placebo-controlled trials. Osteoarthritis Cartilage. 2010;18(3);289-96. PMID 19857509 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Steel CM, Pannirselvam RR, Anderson GA. Risk of septic arthritis after intra-articular medication: a study of 16,624 injections in Thoroughbred racehorses. Aust Vet J. 2013;91(7);268-73. PMID 23782019 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Fukui K, Kaneuji A, Fukushima M, et al. Inversion of the acetabular labrum triggers rapidly destructive osteoarthritis of the hip: representative case report and proposed etiology. J Arthroplasty. 2014;29(12);2468-72. PMID 25081509 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Munigangaiah S, O'Sullivan TA, Lenehan B. Simultaneous bilateral septic arthritis of the knee after intraarticular steroid injection: A clinical report. J Nat Sci Biol Med. 2014;5(2);485-7. PMID 25097444 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Werner BC, Cancienne JM, Browne JA. The Timing of Total Hip Arthroplasty After Intraarticular Hip Injection Affects Postoperative Infection Risk. J Arthroplasty. 2016;31(4);820-3. PMID 26803711 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Flemming DJ, Gustas-French CN. Rapidly Progressive Osteoarthritis: a Review of the Clinical and Radiologic Presentation. Curr Rheumatol Rep. 2017;19(7);42. PMID 28689367 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Delgado-Noguera MF, Forero Delgadillo JM, Franco AA, et al. Corticosteroids for septic arthritis in children. Cochrane Database Syst Rev. 2018;11(11);CD012125. PMID 30480764 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Ross KM, Mehr JS, Carothers BL, et al. Bacterial septic arthritis infections associated with intra-articular injection practices for osteoarthritis knee pain-New Jersey, 2017. Infect Control Hosp Epidemiol. 2019;40(9);1013-1018. PMID 31311611 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Petersen SK, Hansen I, Andreasen RA. Low frequency of septic arthritis after arthrocentesis and intra-articular glucocorticoid injection. Scand J Rheumatol. 2019;48(5);393-397. PMID 31146626 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Wagenaar FBM, Löwik CAM, Zahar A, et al. Persistent Wound Drainage After Total Joint Arthroplasty: A Narrative Review. J Arthroplasty. 2019;34(1);175-182. PMID 30245124 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Zeng L, Yu G, Hao W, et al. The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis. Biosci Rep. 2021;41(6);BSR20210817. PMID 34017975 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Sabatini FM, Cohen-Rosenblum A, Eason TB, et al. Incidence of Rapidly Progressive Osteoarthritis Following Intra-articular Hip Corticosteroid Injection: A Systematic Review and Meta-Analysis. Arthroplast Today. 2023;24;101242. PMID 37941925 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Montero Furelos LA, De Castro Carrasco A, Cons Lamas S, et al. Rapidly Progressive Osteoarthritis of the Hip: A Prospective Study. J Clin Med. 2024;13(9);2467. PMID 38730996 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Chau HTH, Wong PY, Pan NY, et al. Rapidly destructive hip osteoarthritis: a diagnosis not to miss. Br J Radiol. 2024;97(1161);1526-1533. PMID 38936340 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Oprișan A, Feier AM, Zuh SG, et al. The Presentation, Clinical Diagnosis, Risk Factors, and Management of Rapidly Progressive Hip Osteoarthritis: A Narrative Literature Review. J Clin Med. 2024;13(20);6194. PMID 39458144 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Naik H. Arthritis: Septic Arthritis. FP Essent. 2025;548;18-24. PMID 39836892 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Vidal F, Carles M, Courjon J. Intra-articular procedures and associated septic arthritis: A mini-review. Infect Dis Now. 2025;55(1);105023. PMID 39798919 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Kano Y. Predictive value of preceding fever or rigor for septic arthritis in acute monoarthritis: A retrospective observational study. Am J Emerg Med. 2025;98;334-338. PMID 41138310 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Cooper C, Horace R, Wilson R. Risk of septic arthritis after corticosteroid joint injections: A retrospective propensity score-matched cohort analysis. PM R. 2025;17(11);1260-1266. PMID 40607839 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns
• Bayrak Demirel O, Demirel M, Bayrak OC, et al. Differentiating septic arthritis from non-infectious inflammatory causes of acute monoarticular arthritis in children: A machine learning approach based on routine laboratory tests. Ir J Med Sci. 2026;10.1007/s11845-026-04560-3. PMID 42467382 — tags: [wiki-red-flags-and-safety-concerns] — cited by: wiki/red-flags-and-safety-concerns

Wiki — Surgery And Joint Replacement

• Lewis DP, Wæver D, Thorninger R, et al. Hemiarthroplasty vs Total Hip Arthroplasty for the Management of Displaced Neck of Femur Fractures: A Systematic Review and Meta-Analysis. J Arthroplasty. 2019;34(8);1837-1843.e2. PMID 31060915 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Crompton J, Osagie-Clouard L, Patel A. Do hip precautions after posterior-approach total hip arthroplasty affect dislocation rates? A systematic review of 7 studies with 6,900 patients. Acta Orthop. 2020;91(6);687-692. PMID 32718213 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Dillon MT, Page RS, Graves SE, et al. Early revision in anatomic total shoulder arthroplasty in osteoarthritis: a cross-registry comparison. Shoulder Elbow. 2020;12(1 Suppl);81-87. PMID 33343719 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Gill DRJ, Page BMedSci RS, Graves SE, et al. A Comparison of Revision Rates for Osteoarthritis of Primary Reverse Total Shoulder Arthroplasty to Primary Anatomic Shoulder Arthroplasty with a Cemented All-polyethylene Glenoid: Analysis from the Australian Orthopaedic Association National Joint Replacement Registry. Clin Orthop Relat Res. 2021;479(10);2216-2224. PMID 34180871 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Shapira J, Chen SL, Rosinsky PJ, et al. Outcomes of outpatient total hip arthroplasty: a systematic review. Hip Int. 2021;31(1);4-11. PMID 32157903 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Vajapey SP, McKeon JF, Krueger CA, et al. Outcomes of total joint arthroplasty in patients with depression: A systematic review. J Clin Orthop Trauma. 2021;18;187-198. PMID 34026486 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Gademan MGJ, Van Steenbergen LN, Cannegieter SC, et al. Population-based 10-year cumulative revision risks after hip and knee arthroplasty for osteoarthritis to inform patients in clinical practice: a competing risk analysis from the Dutch Arthroplasty Register. Acta Orthop. 2021;92(3);280-284. PMID 33478320 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Moran MM, Wessman P, Rolfson O, et al. The risk of revision following total hip arthroplasty in patients with inflammatory bowel disease, a registry based study. PLoS One. 2021;16(11);e0257310. PMID 34735461 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Cooper HJ, Bongards C, Silverman RP. Cost-Effectiveness of Closed Incision Negative Pressure Therapy for Surgical Site Management After Revision Total Knee Arthroplasty: Secondary Analysis of a Randomized Clinical Trial. J Arthroplasty. 2022;37(8S);S790-S795. PMID 35288248 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• O'Connor JP, Holden P, Gagnier JJ. Systematic review: preoperative psychological factors and total hip arthroplasty outcomes. J Orthop Surg Res. 2022;17(1);457. PMID 36253795 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Fowler TJ, Aquilina AL, Reed MR, et al. The association between surgeon grade and risk of revision following total hip arthroplasty : an analysis of National Joint Registry data. Bone Joint J. 2022;104-B(3);341-351. PMID 35227094 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• DeFrance MJ, Scuderi GR. Are 20% of Patients Actually Dissatisfied Following Total Knee Arthroplasty? A Systematic Review of the Literature. J Arthroplasty. 2023;38(3);594-599. PMID 36252743 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Ang JJM, Onggo JR, Stokes CM, et al. Comparing direct anterior approach versus posterior approach or lateral approach in total hip arthroplasty: a systematic review and meta-analysis. Eur J Orthop Surg Traumatol. 2023;33(7);2773-2792. PMID 37010580 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Korfitsen CB, Mikkelsen LR, Mikkelsen ML, et al. Hip precautions after posterior-approach total hip arthroplasty among patients with primary hip osteoarthritis do not influence early recovery: a systematic review and meta-analysis of randomized and non-randomized studies with 8,835 patients. Acta Orthop. 2023;94;141-151. PMID 37039064 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Konnyu KJ, Thoma LM, Cao W, et al. Prehabilitation for Total Knee or Total Hip Arthroplasty: A Systematic Review. Am J Phys Med Rehabil. 2023;102(1);1-10. PMID 35302954 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Riantho A, Butarbutar JCP, Fidiasrianto K, et al. Radiographic Outcomes of Robot-Assisted Versus Conventional Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. JB JS Open Access. 2023;8(2);e23.00010. PMID 37197698 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Konnyu KJ, Pinto D, Cao W, et al. Rehabilitation for Total Hip Arthroplasty: A Systematic Review. Am J Phys Med Rehabil. 2023;102(1);11-18. PMID 35302955 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Zhang Q, Chen Y, Li Y, et al. Enhanced recovery after surgery in patients after hip and knee arthroplasty: a systematic review and meta-analysis. Postgrad Med J. 2024;100(1181);159-173. PMID 38134323 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• de Ree RHGM, de Jong LD, Hazebroek EJ, et al. Optimal timing of hip and knee arthroplasty after bariatric surgery: A systematic review. J Clin Orthop Trauma. 2024;52;102423. PMID 38766387 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Roerink AMC, Nelissen RGHH, Holder C, et al. Sex-based differences in risk of revision for infection after hip, knee, shoulder, and ankle arthroplasty in osteoarthritis patients: a multinational registry study of 4,800,000 implants. Acta Orthop. 2024;95;730-736. PMID 39656214 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Davies AR, Sabharwal S, Liddle AD, et al. The risk of revision is higher following shoulder hemiarthroplasty compared with total shoulder arthroplasty for osteoarthritis: a matched cohort study of 11,556 patients from the National Joint Registry, UK. Acta Orthop. 2024;95;73-85. PMID 38289339 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Huerfano E, Bautista M, Huerfano M, et al. Total hip arthroplasty in adolescents: a systematic review and meta-analysis. Int Orthop. 2024;48(9);2483-2492. PMID 38619564 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Hall MC, Smith B, Sheehan KJ, et al. Non-surgical interventions for arthrofibrosis following knee joint replacement: A systematic review. Clin Rehabil. 2025;39(5);580-599. PMID 40111909 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement
• Keogh JAJ, Keng I, Dhillon DS, et al. The Effects of Structured Prehabilitation on Postoperative Outcomes Following Total Hip and Total Knee Arthroplasty: An Overview of Systematic Reviews and Meta-analyses of Randomized Controlled Trials. J Orthop Sports Phys Ther. 2025;55(5);344-365. PMID 40298246 — tags: [wiki-surgery-and-joint-replacement] — cited by: wiki/surgery-and-joint-replacement

Deepening 2026-08-31 — newly cited landmark records

Every PMID below was returned by live PubMed E-utilities esearch/efetch in the 2026-08-31 deepening session.

• Losina E, Weinstein AM, Reichmann WM, et al. Lifetime risk and age at diagnosis of symptomatic knee osteoarthritis in the US. Arthritis Care Res (Hoboken). 2013;65:703-11. PMID 23203864 — tags: [epidemiology, lifetime-risk] — cited by: wiki/overview, wiki/epidemiology-and-burden
• Dillon CF, Rasch EK, Gu Q, et al. Prevalence of knee osteoarthritis in the United States: arthritis data from NHANES III 1991-94. J Rheumatol. 2006;33:2271-9. PMID 17013996 — tags: [epidemiology, NHANES] — cited by: wiki/epidemiology-and-burden
• Murphy LB, Helmick CG, Schwartz TA, et al. One in four people may develop symptomatic hip osteoarthritis in his or her lifetime. Osteoarthritis Cartilage. 2010;18:1372-9. PMID 20713163 — tags: [epidemiology, hip] — cited by: wiki/overview, wiki/epidemiology-and-burden, wiki/hip-osteoarthritis
• Safiri S, Kolahi AA, Smith E, et al. Global, regional and national burden of osteoarthritis 1990-2017. Ann Rheum Dis. 2020;79:819-828. PMID 32398285 — tags: [epidemiology, GBD] — cited by: wiki/epidemiology-and-burden
• Wallace IJ, Worthington S, Felson DT, et al. Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proc Natl Acad Sci U S A. 2017;114:9332-9336. PMID 28808025 — tags: [epidemiology, secular-trend] — cited by: wiki/epidemiology-and-burden
• Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis of the knee. Arthritis Rheum. 1986;29:1039-49. PMID 3741515 — tags: [diagnosis, ACR] — cited by: wiki/diagnosis-and-classification
• Altman R, Alarcon G, Appelrouth D, et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum. 1991;34:505-14. PMID 2025304 — tags: [diagnosis, ACR, hip] — cited by: wiki/diagnosis-and-classification
• Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16:494-502. PMID 13498604 — tags: [diagnosis, radiography] — cited by: wiki/diagnosis-and-classification
• Zhang W, Doherty M, Peat G, et al. EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis. Ann Rheum Dis. 2010;69:483-9. PMID 19762361 — tags: [diagnosis, EULAR] — cited by: wiki/diagnosis-and-classification
• Guermazi A, Niu J, Hayashi D, et al. Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis. BMJ. 2012;345:e5339. PMID 22932918 — tags: [imaging, discordance] — cited by: wiki/diagnosis-and-classification, wiki/biomarkers-and-imaging-markers
• Hannan MT, Felson DT, Pincus T. Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee. J Rheumatol. 2000;27:1513-7. PMID 10852280 — tags: [pain, discordance] — cited by: wiki/diagnosis-and-classification, wiki/pain-mechanisms-and-sensitization
• Glasson SS, Askew R, Sheppard B, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature. 2005;434:644-8. PMID 15800624 — tags: [mechanism, aggrecanase] — cited by: wiki/cartilage-bone-and-synovium
• Little CB, Meeker CT, Golub SB, et al. Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. J Clin Invest. 2007;117:1627-36. PMID 17510707 — tags: [mechanism, aggrecan] — cited by: wiki/cartilage-bone-and-synovium
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