Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial.

One-paragraph summary

Compared three 16-week first-line drug pathways and combination rescue. (PMID 36007534)

Key findings

• Compared three 16-week first-line drug pathways and combination rescue.

Limitations

• Population, follow-up, comparator and outcome definitions constrain generalization.

Why it matters

This paper changed diagnostic, preventive or treatment practice and anchors multiple wiki pages.

Cited by wiki pages

• diabetic-neuropathic-pain.md
• clinical-trials-landscape.md
• pharmacologic-treatment.md