Created:INDEX.md (18-row canonical Pages table), wiki/overview.md (draft, 27 verified PMIDs), OPEN-QUESTIONS.md (7 seed questions), and this log.
Searches run (live PubMed E-utilities esearch/esummary): global stroke burden; acute ischemic stroke definition and treatment; NINDS/ECASS alteplase and time-to-treatment meta-analysis; AcT tenecteplase; MR CLEAN, HERMES, DAWN and DEFUSE 3 thrombectomy; stroke-unit care; ICH guideline and INTERACT2; secondary-prevention guideline, PROGRESS, CHANCE/POINT, ARISTOTLE, ECST and DEFENSE-PFO; stroke rehabilitation standards; small-vessel disease; premature stroke; neuroprotection.
Verification: every cited PMID was returned by live PubMed in this session; claims were limited to the retrieved article's scope.
Next: full build queued per CONDITIONS-ROADMAP.md; build remaining canonical pages, literature and patient-voice layers, verify trials against ClinicalTrials.gov, and independently audit claim–citation pairs.
Built all 18 canonical wiki pages: extended overview.md; added classification/workup, epidemiology/burden, penumbra biology, cerebral small-vessel disease, acute ischemic stroke, ICH, SAH, systems of care, secondary prevention, cardioembolic/cryptogenic stroke, rehabilitation, outcomes, guidelines, biomarkers, trial landscape, patient experience, and red-flags pages. All remain status: draft pending the separate audit required by the playbook.
Built the literature layer: 399-record cross-indexed BIBLIOGRAPHY.md; five landmark notes (NINDS alteplase, HERMES, DAWN, INTERACT2, organized stroke-unit care); a 29-record guideline registry with supersession chains, disagreements and watch list; 196-line statistics quick reference; and four patient-voice files.
Rebuilt the research frontier:OPEN-QUESTIONS.md now has 16 Tier 1 questions, eight Tier 2 questions, stable OQ IDs, design implications, and a 12-row “Dots not yet connected” table.
PubMed searches: more than 300 live E-utilities searches across definitions/mimics/imaging; global and regional burden; ischemic biology/collaterals/BBB; thrombolysis/thrombectomy; ICH/SAH; prevention/AF/ESUS/PFO/carotid disease; small-vessel disease; rehabilitation/outcomes; systems/prehospital care; guidelines; biomarkers; and qualitative patient/caregiver research. Final whole-condition ESummary retrieval resolved all 399 distinct PMIDs.
ClinicalTrials.gov: live v2 condition searches covered acute ischemic stroke, ICH, and rehabilitation. All 30 distinct NCT IDs used in the condition were then re-fetched from their individual v2 study endpoints; 30/30 resolved.
Patient voice: 12 organization sites and two public story hubs returned HTTP 200 and were catalogued with access dates. Themes are aggregate, public-source only, and each has at least two sources.
Could not verify through direct site fetch: AHA professional pages, American Stroke Association, Stroke Association UK, National Aphasia Association, and Aphasia Recovery Connection returned HTTP 403; several legacy India/South Africa/SAFE domains failed DNS; guessed story URLs returning 403/404 were not used. These failures are explicitly quarantined in the registry/patient-voice coverage notes; PubMed-indexed AHA/ASA guideline identity remains live-verified through E-utilities.
Validation: required page sections/frontmatter present; wiki page lengths within 150–400 lines; inline/reference PMID sets match; local Markdown links resolve; NCT IDs resolve; no unresolved verification markers remain; no prohibited paths were changed and no Git command was run.
Next: run the build playbook's independent audit in a fresh session, re-check each claim–citation pair and quoted number, fix any substantive mismatch, and only then promote passing pages to curated and roadmap status to audited.
Scope completed: audited all 18 canonical wiki pages and every literature artifact: the 407-record bibliography, five landmark notes, 31-row guideline registry, statistics tables, and all four patient-voice files. Checked 942 wiki-body PMID mentions against the retrieved records, plus 488 page-reference entries and 239 PMID mentions in non-bibliography literature artifacts. All 407 distinct PMIDs resolved through live PubMed E-utilities; six group-authored records omitted from one batch response were re-queried individually and resolved. All 30 distinct NCT IDs (45 mentions) resolved through the ClinicalTrials.gov v2 individual-study endpoint.
Errors found and fixed — 14 correction sites: two repeated DAWN numerical errors (control utility-weighted mRS corrected from 2.1 to 3.4 in acute-ischemic-stroke.md and outcomes-and-prognostication.md); one wrong inline author label (Rensma → Fang for PMID 32715831); ten collective-author/metadata citation entries repaired across page references and BIBLIOGRAPHY.md (ECST, SPS3 blood-pressure and antiplatelet reports, AVERT, CAST, IST, WFNS, and NASCET); and one stale guideline-map assertion corrected after the new AHA/ASA adult rehabilitation guideline was located.
Fresh searches behind absence/gap claims: reran PubMed searches for post-stroke insomnia incidence, blood biomarkers replacing imaging, human no-reflow treatment phenotypes, aSAH external-ventricular-drain weaning, 2025–2026 stroke guidelines, and clinical neuroprotection trials. Converted the insomnia, blood-biomarker, EVD-weaning, and neuroprotection statements into positively stated evidence gaps dated 2026-08-30, adding current effect sizes and boundaries rather than retaining timeless absence claims.
Current evidence added (all live-retrieved): the AHA/ASA 2026 adult rehabilitation guideline (PMID 42657476), the SVIN 2026 distal/medium-vessel thrombectomy focused guideline (PMID 42404835), a 2026 post-stroke insomnia cohort (PMID 41924789), acute-vertigo blood-biomarker study (PMID 41961296), EVD-weaning meta-analysis (PMID 41949294), EnTRIPS post-conditioning RCT (PMID 42267436), phase IIb adjunctive normobaric-hyperoxia RCT (PMID 42403344), and preliminary DSA no-reflow prediction work (PMID 42184179). The bibliography therefore increased from 399 to 407 distinct records and the guideline registry from 29 to 31 rows.
Registry and web verification: every one of the 30 trial rows still matched live status, planned/actual enrollment, and phase. All 14 organization/story-hub URLs and the NICE, Australian living-guideline, and Canadian guideline endpoints returned HTTP 200 on 2026-08-30; access dates were refreshed. Landmark-note PMIDs and DOIs matched PubMed.
Validation passed: 18/18 pages remain within 150–400 lines; required frontmatter/TL;DR/open-questions/related-pages/references sections are present; every page's body PMID set exactly matches its references; all local wiki links target canonical pages; all used PMIDs occur exactly once in the bibliography and every bibliography record has a downstream use; no duplicate PMID entry, unresolved link, verification marker, or substantive citation mismatch remains.
Disposition: promoted all 18 pages to status: curated; updated INDEX.md and CONDITIONS-ROADMAP.md to audited. Nothing remains flagged for citation resolution. Continuing scientific uncertainties are retained as dated open questions or guideline watch-list items, not verification failures.