{
 "condition": "stroke",
 "sweep_date": "2026-10-20",
 "author_engine": "Claude (Anthropic)",
 "window": {
  "from": "2026-08-28",
  "to": "2026-10-20",
  "date_field": "PubMed [Date - Publication] (one Cochrane query also by [edat]); Europe PMC FIRST_PDATE",
  "interpretation": "Publication-date window; includes some records e-published before 2026-08-28 whose print date falls in-window."
 },
 "pubmed_esearch": {
  "all": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 5207,
   "ids": []
  },
  "classification-workup": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (mimic*[tiab] OR \"transient ischemic attack\"[tiab] OR TIA[tiab] OR \"diagnostic accuracy\"[tiab] OR TOAST[tiab] OR misdiagnos*[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"mimic*\"[Title/Abstract] OR \"transient ischemic attack\"[Title/Abstract] OR \"TIA\"[Title/Abstract] OR \"diagnostic accuracy\"[Title/Abstract] OR \"TOAST\"[Title/Abstract] OR \"misdiagnos*\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 35,
   "ids": [
    "42821840",
    "42866879",
    "42748394",
    "42848092",
    "42841215",
    "42786657",
    "42837286",
    "42636678",
    "42418757",
    "42269861",
    "42087032",
    "41568775",
    "40542821",
    "42876773",
    "42876495",
    "42851412",
    "42785737",
    "42778898",
    "42767275",
    "42777111",
    "42753254",
    "42859543",
    "42723534",
    "42670979",
    "42713886",
    "42704590",
    "42707892",
    "42878597",
    "42537727",
    "42307458",
    "42302394",
    "42218849",
    "41801307",
    "41791634",
    "42667231"
   ]
  },
  "epidemiology-burden": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"global burden\"[tiab] OR incidence[ti] OR prevalence[ti] OR \"Global Burden of Disease\"[tiab] OR GBD[tiab] OR mortality[ti]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"global burden\"[Title/Abstract] OR \"incidence\"[Title] OR \"prevalence\"[Title] OR \"Global Burden of Disease\"[Title/Abstract] OR \"GBD\"[Title/Abstract] OR \"mortality\"[Title]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 24,
   "ids": [
    "42745683",
    "42848227",
    "42808440",
    "42832041",
    "42826016",
    "42679840",
    "42663055",
    "42526164",
    "42336097",
    "41934293",
    "41294218",
    "42877103",
    "42736741",
    "42720234",
    "42869063",
    "42743071",
    "42701683",
    "42699213",
    "42506988",
    "42081237",
    "41942673",
    "41833723",
    "38990003",
    "42670293"
   ]
  },
  "penumbra-biology": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (penumbra[tiab] OR collateral*[tiab] OR \"reperfusion injury\"[tiab] OR \"no-reflow\"[tiab] OR neuroprotect*[tiab] OR \"blood-brain barrier\"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"penumbra\"[Title/Abstract] OR \"collateral*\"[Title/Abstract] OR \"reperfusion injury\"[Title/Abstract] OR \"no-reflow\"[Title/Abstract] OR \"neuroprotect*\"[Title/Abstract] OR \"blood-brain barrier\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 31,
   "ids": [
    "42679920",
    "42844856",
    "42831671",
    "42828605",
    "42892901",
    "42607786",
    "42462342",
    "42341998",
    "42336097",
    "41568775",
    "42705987",
    "42817137",
    "42809028",
    "42775432",
    "42840117",
    "42767275",
    "42751921",
    "42425262",
    "42721021",
    "42711080",
    "42709254",
    "42706345",
    "42747864",
    "42683771",
    "42707803",
    "42698301",
    "42497969",
    "42483807",
    "42460477",
    "42381628",
    "42360458"
   ]
  },
  "small-vessel": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"small vessel disease\"[tiab] OR \"small-vessel disease\"[tiab] OR lacun*[tiab] OR \"white matter hyperintensit*\"[tiab] OR microbleed*[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"small-vessel disease\"[Title/Abstract] OR \"small-vessel disease\"[Title/Abstract] OR \"lacun*\"[Title/Abstract] OR \"white matter hyperintensit*\"[Title/Abstract] OR \"microbleed*\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 8,
   "ids": [
    "42858287",
    "42848092",
    "41934293",
    "41605866",
    "42349084",
    "42614618",
    "42532456",
    "42155300"
   ]
  },
  "acute-ischemic-thrombolysis": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (thromboly*[tiab] OR alteplase[tiab] OR tenecteplase[tiab] OR reteplase[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"thromboly*\"[Title/Abstract] OR \"alteplase\"[Title/Abstract] OR \"tenecteplase\"[Title/Abstract] OR \"reteplase\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 43,
   "ids": [
    "42886317",
    "42886241",
    "42480380",
    "42859208",
    "42669921",
    "42851038",
    "42727034",
    "42689322",
    "42644244",
    "42607786",
    "42565455",
    "42526164",
    "42213333",
    "41671570",
    "40990648",
    "40801885",
    "39246132",
    "42804200",
    "42803981",
    "42788228",
    "42776543",
    "42623571",
    "42762269",
    "42777111",
    "42758278",
    "42749350",
    "42813025",
    "42812199",
    "41136212",
    "42711080",
    "42704605",
    "42734928",
    "42755478",
    "42537729",
    "42497969",
    "42488952",
    "42483807",
    "42258034",
    "40659573",
    "42675092",
    "42670735",
    "42729340",
    "42729048"
   ]
  },
  "acute-ischemic-thrombectomy": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (thrombectomy[tiab] OR endovascular[tiab] OR \"large vessel occlusion\"[tiab] OR \"large core\"[tiab] OR \"medium vessel\"[tiab] OR \"distal vessel\"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"thrombectomy\"[Title/Abstract] OR \"endovascular\"[Title/Abstract] OR \"large vessel occlusion\"[Title/Abstract] OR \"large core\"[Title/Abstract] OR \"medium vessel\"[Title/Abstract] OR \"distal vessel\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 91,
   "ids": [
    "42715615",
    "42893468",
    "42886317",
    "42886241",
    "42480380",
    "41339078",
    "42852505",
    "42848053",
    "42844856",
    "42844891",
    "42669921",
    "42831671",
    "42867860",
    "42861756",
    "42727034",
    "42607786",
    "42565455",
    "42526164",
    "42468039",
    "42440218",
    "42423416",
    "42284631",
    "42178454",
    "42083289",
    "41935978",
    "41771155",
    "41706582",
    "41671570",
    "41637662",
    "41568775",
    "41029948",
    "41026943",
    "40990648",
    "40953191",
    "40801885",
    "40717608",
    "40660916",
    "40452472",
    "40398477",
    "40398471",
    "40398466",
    "40254985",
    "39267355",
    "39246132",
    "42876773",
    "42871239",
    "42809482",
    "42809028",
    "42827913",
    "42804200",
    "42803981",
    "42785737",
    "42776543",
    "42770646",
    "42623571",
    "42767728",
    "42777111",
    "42760130",
    "42758278",
    "42813025",
    "42349084",
    "41136212",
    "42425262",
    "42787098",
    "42780889",
    "42716680",
    "42711461",
    "42706345",
    "42585603",
    "42622212",
    "42621146",
    "42545711",
    "42498265",
    "42495732",
    "42485024",
    "42460477",
    "42456970",
    "42456958",
    "42414634",
    "42381628",
    "42360458",
    "42258034",
    "42084585",
    "41801307",
    "41746322",
    "40946161",
    "40659573",
    "42670735",
    "42729340",
    "42729048",
    "42665158"
   ]
  },
  "ich": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"intracerebral hemorrhage\"[tiab] OR \"intracerebral haemorrhage\"[tiab] OR \"hematoma expansion\"[tiab] OR andexanet[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"hematoma expansion\"[Title/Abstract] OR \"andexanet\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 31,
   "ids": [
    "42691720",
    "42715615",
    "42848972",
    "42679920",
    "42830311",
    "42870767",
    "42821508",
    "42644244",
    "42617990",
    "42558067",
    "42087030",
    "42010003",
    "41934293",
    "41641790",
    "42827913",
    "42735090",
    "42736741",
    "42710698",
    "42708556",
    "42704590",
    "42747864",
    "42806719",
    "42740560",
    "42586098",
    "42585721",
    "42492370",
    "42484370",
    "42190986",
    "42190804",
    "41496301",
    "40659573"
   ]
  },
  "sah": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"subarachnoid hemorrhage\"[tiab] OR \"subarachnoid haemorrhage\"[tiab] OR aneurysm*[tiab] OR vasospasm[tiab] OR \"delayed cerebral ischemia\"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract] OR \"aneurysm*\"[Title/Abstract] OR \"vasospasm\"[Title/Abstract] OR \"delayed cerebral ischemia\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 36,
   "ids": [
    "42885258",
    "42848158",
    "42848053",
    "42679840",
    "42647980",
    "42617990",
    "42552475",
    "42468039",
    "42423416",
    "42341998",
    "42087032",
    "42083289",
    "41975120",
    "41906705",
    "41622833",
    "41026943",
    "40953191",
    "40717608",
    "40660916",
    "42778898",
    "41979041",
    "42242899",
    "41120206",
    "40813071",
    "42780004",
    "42711461",
    "42709254",
    "42706345",
    "42684449",
    "42678455",
    "42496900",
    "42190986",
    "42150371",
    "41496301",
    "41255278",
    "42665158"
   ]
  },
  "systems-of-care": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"stroke unit\"[tiab] OR prehospital[tiab] OR \"mobile stroke unit\"[tiab] OR telestroke[tiab] OR \"door-to-needle\"[tiab] OR transfer[tiab] OR \"quality improvement\"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"stroke unit\"[Title/Abstract] OR \"prehospital\"[Title/Abstract] OR \"mobile stroke unit\"[Title/Abstract] OR \"telestroke\"[Title/Abstract] OR \"door-to-needle\"[Title/Abstract] OR \"transfer\"[Title/Abstract] OR \"quality improvement\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 18,
   "ids": [
    "42829971",
    "42407017",
    "41641790",
    "40452472",
    "42809588",
    "42803981",
    "42785737",
    "42770646",
    "42812199",
    "42710698",
    "42703715",
    "42755478",
    "42622212",
    "42497969",
    "42414634",
    "42190804",
    "42084585",
    "42729340"
   ]
  },
  "secondary-prevention": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"secondary prevention\"[tiab] OR antiplatelet[tiab] OR clopidogrel[tiab] OR ticagrelor[tiab] OR statin*[tiab] OR \"blood pressure\"[tiab] OR carotid[tiab] OR \"recurrent stroke\"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"secondary prevention\"[Title/Abstract] OR \"antiplatelet\"[Title/Abstract] OR \"clopidogrel\"[Title/Abstract] OR \"ticagrelor\"[Title/Abstract] OR \"statin*\"[Title/Abstract] OR \"blood pressure\"[Title/Abstract] OR \"carotid\"[Title/Abstract] OR \"recurrent stroke\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 116,
   "ids": [
    "42821840",
    "42815042",
    "42745683",
    "42744018",
    "42678121",
    "42848972",
    "42892998",
    "42894060",
    "42875834",
    "42607744",
    "42546365",
    "42866879",
    "42748394",
    "42860163",
    "42859208",
    "42852505",
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    "42669071",
    "42669035",
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   ]
  },
  "cardioembolic-cryptogenic": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"atrial fibrillation\"[tiab] OR ESUS[tiab] OR cryptogenic[tiab] OR \"patent foramen ovale\"[tiab] OR anticoagula*[tiab] OR \"left atrial appendage\"[tiab] OR \"factor XI\"[tiab] OR asundexian[tiab] OR milvexian[tiab] OR abelacimab[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"atrial fibrillation\"[Title/Abstract] OR \"ESUS\"[Title/Abstract] OR \"cryptogenic\"[Title/Abstract] OR \"patent foramen ovale\"[Title/Abstract] OR \"anticoagula*\"[Title/Abstract] OR \"left atrial appendage\"[Title/Abstract] OR \"factor XI\"[Title/Abstract] OR \"asundexian\"[Title/Abstract] OR \"milvexian\"[Title/Abstract] OR \"abelacimab\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 72,
   "ids": [
    "42805026",
    "42821842",
    "42866879",
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    "38990003",
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    "42667231"
   ]
  },
  "rehabilitation": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (rehabilitat*[tiab] OR aphasia[tiab] OR \"upper limb\"[tiab] OR \"vagus nerve stimulation\"[tiab] OR \"motor recovery\"[tiab] OR spasticity[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"rehabilitat*\"[Title/Abstract] OR \"aphasia\"[Title/Abstract] OR \"upper limb\"[Title/Abstract] OR \"vagus nerve stimulation\"[Title/Abstract] OR \"motor recovery\"[Title/Abstract] OR \"spasticity\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 143,
   "ids": [
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    "42729965",
    "42729340",
    "42729195",
    "42684273",
    "42607705"
   ]
  },
  "outcomes-prognosis": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (prognos*[tiab] OR \"modified Rankin\"[tiab] OR \"post-stroke cognitive\"[tiab] OR \"poststroke cognitive\"[tiab] OR \"post-stroke depression\"[tiab] OR \"poststroke depression\"[tiab] OR fatigue[tiab] OR \"return to work\"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"prognos*\"[Title/Abstract] OR \"modified Rankin\"[Title/Abstract] OR \"post-stroke cognitive\"[Title/Abstract] OR \"poststroke cognitive\"[Title/Abstract] OR \"post-stroke depression\"[Title/Abstract] OR \"poststroke depression\"[Title/Abstract] OR \"fatigue\"[Title/Abstract] OR \"return to work\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 152,
   "ids": [
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    "42727543",
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    "40990648",
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    "42704590",
    "42704480",
    "42761006",
    "42760929",
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    "42755508",
    "42683771",
    "42878597",
    "42710847",
    "42707803",
    "42688575",
    "42687126",
    "42585721",
    "42570806",
    "42552177",
    "42498265",
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    "42496900",
    "42495732",
    "42492370",
    "42485024",
    "42483807",
    "42467386",
    "42460477",
    "42456970",
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    "40946161",
    "40659573",
    "42675092",
    "42674805",
    "42729048"
   ]
  },
  "biomarkers": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (biomarker*[tiab] OR GFAP[tiab] OR \"neurofilament\"[tiab] OR \"perfusion imaging\"[tiab] OR \"artificial intelligence\"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"biomarker*\"[Title/Abstract] OR \"GFAP\"[Title/Abstract] OR \"neurofilament\"[Title/Abstract] OR \"perfusion imaging\"[Title/Abstract] OR \"artificial intelligence\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 46,
   "ids": [
    "42885258",
    "42886317",
    "42876068",
    "42857900",
    "42848092",
    "42841486",
    "42757936",
    "42867860",
    "42861756",
    "42829971",
    "42689322",
    "42607786",
    "42087032",
    "42817137",
    "42788867",
    "42851412",
    "42785737",
    "42784901",
    "42840117",
    "42766685",
    "42766680",
    "42763842",
    "42751921",
    "42812344",
    "42610271",
    "42425262",
    "42716572",
    "42713886",
    "42760929",
    "42707892",
    "42691252",
    "42707803",
    "42706959",
    "42698301",
    "42687126",
    "42622212",
    "42614618",
    "42537729",
    "42483807",
    "42414634",
    "42155300",
    "42150371",
    "42120210",
    "42049068",
    "42675092",
    "42250854"
   ]
  },
  "patient-experience": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (caregiver*[tiab] OR carer*[tiab] OR qualitative[tiab] OR \"lived experience\"[tiab] OR \"patient-reported\"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt] OR guideline[pt] OR practice guideline[pt] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"caregiver*\"[Title/Abstract] OR \"carer*\"[Title/Abstract] OR \"qualitative\"[Title/Abstract] OR \"lived experience\"[Title/Abstract] OR \"patient-reported\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title] OR \"trial\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 30,
   "ids": [
    "42865266",
    "42862086",
    "42825924",
    "42892901",
    "42696967",
    "42679412",
    "42657476",
    "42571232",
    "42140823",
    "42126820",
    "42083289",
    "41800806",
    "41781013",
    "41778502",
    "42876799",
    "42852744",
    "42816085",
    "42809354",
    "42803430",
    "42772871",
    "42754280",
    "42728242",
    "42704590",
    "42755662",
    "42769401",
    "42740560",
    "42488952",
    "41666123",
    "41664923",
    "42729340"
   ]
  },
  "cochrane-stroke": {
   "query": "\"Cochrane Database Syst Rev\"[jour] AND (stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 5,
   "ids": [
    "42781846",
    "42764178",
    "42742033",
    "42713886",
    "42695385"
   ]
  },
  "cochrane-stroke-edat": {
   "query": "\"Cochrane Database Syst Rev\"[jour] AND (stroke[tiab] OR cerebrovascular[tiab] OR \"intracranial hemorrhage\"[tiab] OR aphasia[tiab] OR hemipar*[tiab]) AND (\"2026/08/28\"[edat] : \"2026/10/20\"[edat])",
   "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"stroke\"[Title/Abstract] OR \"cerebrovascular\"[Title/Abstract] OR \"intracranial hemorrhage\"[Title/Abstract] OR \"aphasia\"[Title/Abstract] OR \"hemipar*\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Entry]",
   "count": 5,
   "ids": [
    "42781846",
    "42764178",
    "42742033",
    "42713886",
    "42695385"
   ]
  },
  "guidelines": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (guideline[pt] OR practice guideline[pt] OR guideline[ti] OR \"scientific statement\"[ti] OR consensus[ti] OR recommendation*[ti]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"guideline\"[Title] OR \"scientific statement\"[Title] OR \"consensus\"[Title] OR \"recommendation*\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 46,
   "ids": [
    "42741845",
    "42886153",
    "42877955",
    "42758512",
    "42844837",
    "42843567",
    "42786624",
    "42824889",
    "42823897",
    "42817881",
    "42804552",
    "42657476",
    "42648009",
    "42552475",
    "42454751",
    "42229617",
    "41568775",
    "41133376",
    "42809101",
    "42786382",
    "42773699",
    "42771011",
    "42484019",
    "42758665",
    "42762208",
    "42377292",
    "42706205",
    "42727963",
    "42726040",
    "42704068",
    "42703764",
    "42703353",
    "42694467",
    "42683974",
    "42780603",
    "42712147",
    "42535283",
    "42473796",
    "42454915",
    "42190804",
    "42190798",
    "42183183",
    "42176356",
    "41967716",
    "41837852",
    "42665234"
   ]
  },
  "topjournals": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"N Engl J Med\"[jour] OR \"Lancet\"[jour] OR \"JAMA\"[jour] OR \"BMJ\"[jour] OR \"Lancet Neurol\"[jour] OR \"JAMA Neurol\"[jour]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"N Engl J Med\"[Journal] OR \"Lancet\"[Journal] OR \"JAMA\"[Journal] OR \"BMJ\"[Journal] OR \"Lancet Neurol\"[Journal] OR \"JAMA Neurol\"[Journal]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 37,
   "ids": [
    "42895730",
    "42815506",
    "42758512",
    "42772314",
    "42679840",
    "42671865",
    "42670961",
    "42636016",
    "42606848",
    "42804200",
    "42785800",
    "42663323",
    "42663303",
    "42778212",
    "42776543",
    "42623085",
    "42623045",
    "42766300",
    "42669300",
    "42734938",
    "42669307",
    "42721023",
    "42721021",
    "42721018",
    "42670979",
    "42709430",
    "42684258",
    "42586098",
    "42545711",
    "42485053",
    "42485024",
    "42670968",
    "42670965",
    "42670964",
    "42670955",
    "42667231",
    "42665319"
   ]
  },
  "statistics": {
   "query": "(stroke[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"Global Burden of Disease\"[tiab] OR GBD[tiab] OR \"statistics\"[ti] OR registry[ti] OR \"heart disease and stroke statistics\"[ti]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
   "translation": "(\"Stroke\"[Title/Abstract] OR \"Stroke\"[MeSH Terms] OR \"intracerebral hemorrhage\"[Title/Abstract] OR \"intracerebral haemorrhage\"[Title/Abstract] OR \"subarachnoid hemorrhage\"[Title/Abstract] OR \"subarachnoid haemorrhage\"[Title/Abstract]) AND (\"Global Burden of Disease\"[Title/Abstract] OR \"GBD\"[Title/Abstract] OR \"statistics\"[Title] OR \"registry\"[Title]) AND 2026/08/28:2026/10/20[Date - Publication]",
   "count": 124,
   "ids": [
    "42734442",
    "42835503",
    "42761622",
    "42824751",
    "42761424",
    "42896742",
    "42895770",
    "42893162",
    "42887713",
    "42885775",
    "42880431",
    "42879357",
    "42447835",
    "42442066",
    "42874593",
    "42870561",
    "42863865",
    "42862855",
    "42861997",
    "42861503",
    "42853400",
    "42850460",
    "42849516",
    "42844013",
    "42843620",
    "42842428",
    "42838357",
    "42838146",
    "42786624",
    "42786616",
    "42667628",
    "42879301",
    "42832467",
    "42832450",
    "42831638",
    "42845010",
    "42825143",
    "42821493",
    "42772298",
    "42676066",
    "42610235",
    "42532482",
    "42532308",
    "42508635",
    "42508625",
    "42495266",
    "42403449",
    "42298270",
    "42252074",
    "42218359",
    "42107684",
    "41984154",
    "41974363",
    "41934293",
    "41728668",
    "41631666",
    "41605880",
    "39043366",
    "42816088",
    "41739048",
    "42808167",
    "42805273",
    "42801415",
    "42791587",
    "42786895",
    "42812767",
    "42788119",
    "42766685",
    "42766680",
    "41914181",
    "42767416",
    "42767390",
    "42767254",
    "42796069",
    "42763076",
    "42760071",
    "42796014",
    "42751781",
    "42873164",
    "42750062",
    "41934630",
    "42750931",
    "30570990",
    "42757302",
    "42745273",
    "42727697",
    "42722732",
    "42731175",
    "42709641",
    "42709158",
    "42360276",
    "42730738",
    "42705504",
    "42717488",
    "42700278",
    "42697181",
    "42894453",
    "42878595",
    "42869063",
    "42856620",
    "42851363",
    "42847089",
    "42780603",
    "42767659",
    "42765781",
    "42698069",
    "42682942",
    "42682935",
    "42622230",
    "42576682",
    "42516272",
    "42485012",
    "42442625",
    "42373365",
    "42269957",
    "42262301",
    "42247831",
    "42030545",
    "41942673",
    "40946161",
    "42739749",
    "42739645",
    "42675717",
    "42668372"
   ]
  }
 },
 "pubmed_esearch_note": "Topic queries (all except 'all', 'cochrane-*', 'guidelines', 'topjournals', 'statistics') were restricted to RCT / meta-analysis / systematic review / guideline publication types or 'randomized/randomised/trial' in title. They are high-evidence filters, not exhaustive topic sweeps. The unfiltered stroke query returned 5,207 records in the window, which were not individually screened.",
 "pubmed_targeted_esearch": {
  "fxia": {
   "query": "(asundexian[tiab] OR milvexian[tiab] OR \"OCEANIC-STROKE\"[tiab] OR \"LIBREXIA\"[tiab]) AND stroke[tiab] AND (randomized controlled trial[pt] OR trial[ti])",
   "count": 21,
   "purpose": "locate the phase 3 trial driving the in-window FXIa meta-analysis; found OCEANIC-STROKE (PMID 41985132, pre-window, absent from the condition)"
  },
  "cochrane_extended": {
   "query": "\"Cochrane Database Syst Rev\"[jour] AND (stroke[tiab] OR cerebrovascular[tiab] OR \"subarachnoid\"[tiab] OR \"intracerebral\"[tiab]) AND (\"2026/08/01\"[dp] : \"2026/10/20\"[dp])",
   "count": 9,
   "purpose": "catch August Cochrane reviews published after the 2026-08-30 audit's searches"
  }
 },
 "cochrane": {
  "in_window_stroke_reviews": [
   "42742033 Cardiorespiratory training for people with stroke (new; splits Saunders 2020)",
   "42713886 Imaging-based models for carotid stenosis (protocol only; not used)"
  ],
  "august_catch_up": [
   "42626977 Brain-computer interface training (used)",
   "42573047 Swallowing therapy for dysphagia (used)",
   "42635089 Synthetic vs biological patches for carotid endarterectomy (not used; procedural detail outside page scope)"
  ],
  "not_searched": "Cochrane Library / CENTRAL (cochranelibrary.com HTTP 403 on 2026-10-20)"
 },
 "europe_pmc": {
  "thrombolysis": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (thrombolysis OR tenecteplase OR alteplase) AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 292,
   "no_pmid": 70,
   "no_pmid_sources": {
    "PMC": 62,
    "PPR": 8
   }
  },
  "thrombectomy": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (thrombectomy OR \"vessel occlusion\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 342,
   "no_pmid": 77,
   "no_pmid_sources": {
    "PPR": 9,
    "PMC": 68
   }
  },
  "ich": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (\"intracerebral hemorrhage\" OR \"intracerebral haemorrhage\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 177,
   "no_pmid": 42,
   "no_pmid_sources": {
    "PMC": 33,
    "PPR": 9
   }
  },
  "sah": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (\"subarachnoid hemorrhage\" OR \"subarachnoid haemorrhage\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 188,
   "no_pmid": 38,
   "no_pmid_sources": {
    "PPR": 14,
    "PMC": 24
   }
  },
  "secondary-prevention": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (\"secondary prevention\" OR antiplatelet OR \"factor XI\" OR asundexian) AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 201,
   "no_pmid": 52,
   "no_pmid_sources": {
    "PPR": 9,
    "PMC": 43
   }
  },
  "cardioembolic": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (\"atrial fibrillation\" OR cryptogenic OR ESUS OR \"patent foramen ovale\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 285,
   "no_pmid": 61,
   "no_pmid_sources": {
    "PMC": 56,
    "PPR": 5
   }
  },
  "neuroprotection": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (neuroprotect* OR edaravone OR loberamisal) AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 189,
   "no_pmid": 34,
   "no_pmid_sources": {
    "PMC": 27,
    "PPR": 7
   }
  },
  "small-vessel": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (\"small vessel disease\" OR lacunar) AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 100,
   "no_pmid": 24,
   "no_pmid_sources": {
    "PPR": 3,
    "PMC": 21
   }
  },
  "rehabilitation": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (rehabilitation OR aphasia OR dysphagia) AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 682,
   "no_pmid": 138,
   "no_pmid_sources": {
    "PMC": 98,
    "PPR": 40
   }
  },
  "systems": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (\"stroke unit\" OR prehospital OR telestroke) AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 114,
   "no_pmid": 22,
   "no_pmid_sources": {
    "PMC": 19,
    "PPR": 3
   }
  },
  "epidemiology": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (\"global burden\" OR incidence OR prevalence) AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 509,
   "no_pmid": 118,
   "no_pmid_sources": {
    "PMC": 96,
    "PPR": 22
   }
  },
  "biomarkers": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (biomarker OR GFAP OR neurofilament) AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 227,
   "no_pmid": 61,
   "no_pmid_sources": {
    "PPR": 14,
    "PMC": 47
   }
  },
  "patient-experience": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (caregiver OR qualitative OR \"lived experience\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 202,
   "no_pmid": 53,
   "no_pmid_sources": {
    "PMC": 40,
    "PPR": 13
   }
  },
  "outcomes": {
   "query": "(TITLE:stroke OR TITLE:\"cerebral hemorrhage\" OR TITLE:\"subarachnoid\") AND (\"modified Rankin\" OR prognosis OR \"post-stroke cognitive\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
   "hitCount": 505,
   "no_pmid": 112,
   "no_pmid_sources": {
    "PPR": 21,
    "PMC": 91
   }
  }
 },
 "europe_pmc_note": "299 distinct non-PMID records were screened by title. One potentially relevant record, PMC13676718 (Lancet Reg Health West Pac, tirofiban vs standard antiplatelet therapy in branch atheromatous disease, phase III), had no PMID, no DOI in Europe PMC and no Crossref match on title search, so it is not citable. Europe PMC fullTextXML returned HTTP 500 for 8 PMC IDs (JAMA/Cochrane records with metadata-only PMC deposits); full text was retrieved for PMC13531381, PMC13619137 and PMC13642444.",
 "clinicaltrials_gov": {
  "endpoint": "https://clinicaltrials.gov/api/v2/studies/{nct}",
  "records": {
   "NCT03243175": {
    "title": "Avoiding Anticoagulation After IntraCerebral Haemorrhage",
    "status": "RECRUITING",
    "last": "2026-04-07",
    "results": false,
    "enroll": {
     "count": 300,
     "type": "ESTIMATED"
    },
    "phase": [
     "PHASE3"
    ],
    "resfirst": null,
    "completion": {
     "date": "2029-12",
     "type": "ESTIMATED"
    }
   },
   "NCT03735901": {
    "title": "Enhancement of Stroke Rehabilitation With Levodopa",
    "status": "ACTIVE_NOT_RECRUITING",
    "last": "2024-10-15",
    "results": false,
    "enroll": {
     "count": 610,
     "type": "ACTUAL"
    },
    "phase": [
     "PHASE3"
    ],
    "resfirst": null,
    "completion": {
     "date": "2029-06-30",
     "type": "ESTIMATED"
    }
   },
   "NCT04625127": {
    "title": "GaitBetter: Motor and Cognitive Training for Gait Rehabilitation and Falls Prevention in Stroke Survivors.",
    "status": "ACTIVE_NOT_RECRUITING",
    "last": "2026-07-13",
    "results": false,
    "enroll": {
     "count": 76,
     "type": "ESTIMATED"
    },
    "phase": [
     "NA"
    ],
    "resfirst": null,
    "completion": {
     "date": "2026-08",
     "type": "ESTIMATED"
    }
   },
   "NCT04667078": {
    "title": "REperfusion With P2Y12 Inhibitors in Addition to mEchanical thRombectomy for perFUsion Imaging Selected Acute Stroke patiEnts",
    "status": "SUSPENDED",
    "last": "2026-09-25",
    "results": false,
    "enroll": {
     "count": 368,
     "type": "ESTIMATED"
    },
    "phase": [
     "PHASE3"
    ],
    "resfirst": null,
    "completion": {
     "date": "2027-12-21",
     "type": "ESTIMATED"
    }
   },
   "NCT05413733": {
    "title": "Neuropsychological Rehabilitation Over the Internet",
    "status": "COMPLETED",
    "last": "2026-09-18",
    "results": false,
    "enroll": {
     "count": 21,
     "type": "ACTUAL"
    },
    "phase": [
     "NA"
    ],
    "resfirst": null,
    "completion": {
     "date": "2025-07-31",
     "type": "ACTUAL"
    }
   },
   "NCT05511285": {
    "title": "Improving Sleep and Learning in Rehabilitation After Stroke, Part 2",
    "status": "RECRUITING",
    "last": "2026-08-10",
    "results": false,
    "enroll": {
     "count": 100,
     "type": "ESTIMATED"
    },
    "phase": [
     "NA"
    ],
    "resfirst": null,
    "completion": {
     "date": "2027-12",
     "type": "ESTIMATED"
    }
   },
   "NCT05789823": {
    "title": "Ischemic Post-conditioning in Acute Ischemic Stroke Thrombectomy (PROTECT-2)",
    "status": "RECRUITING",
    "last": "2025-03-26",
    "results": false,
    "enroll": {
     "count": 160,
     "type": "ESTIMATED"
    },
    "phase": [
     "PHASE2"
    ],
    "resfirst": null,
    "completion": {
     "date": "2026-02-01",
     "type": "ESTIMATED"
    }
   },
   "NCT05830305": {
    "title": "MOBILE Health Intervention in IntraCerebral Hemorrhage Survivors",
    "status": "RECRUITING",
    "last": "2026-01-06",
    "results": false,
    "enroll": {
     "count": 140,
     "type": "ESTIMATED"
    },
    "phase": [
     "NA"
    ],
    "resfirst": null,
    "completion": {
     "date": "2027-03-31",
     "type": "ESTIMATED"
    }
   },
   "NCT05832762": {
    "title": "Evaluation of Acute Endovascular Treatment in Symptomatic Isolated Cervical Internal Carotid Artery Occlusion (ETICA)",
    "status": "RECRUITING",
    "last": "2026-01-28",
    "results": false,
    "enroll": {
     "count": 200,
     "type": "ESTIMATED"
    },
    "phase": [
     "NA"
    ],
    "resfirst": null,
    "completion": {
     "date": "2026-11-01",
     "type": "ESTIMATED"
    }
   },
   "NCT05836831": {
    "title": "Indian Trial of Tranexamic Acid in Spontaneous Intracerebral Haemorrhage",
    "status": "RECRUITING",
    "last": "2026-01-22",
    "results": false,
    "enroll": {
     "count": 3400,
     "type": "ESTIMATED"
    },
    "phase": [
     "PHASE4"
    ],
    "resfirst": null,
    "completion": {
     "date": "2026-11",
     "type": "ESTIMATED"
    }
   },
   "NCT05898542": {
    "title": "Nature-based Therapies in Stroke Rehabilitation",
    "status": "RECRUITING",
    "last": "2024-07-03",
    "results": false,
    "enroll": {
     "count": 60,
     "type": "ESTIMATED"
    },
    "phase": [
     "NA"
    ],
    "resfirst": null,
    "completion": {
     "date": "2026-12-31",
     "type": "ESTIMATED"
    }
   },
   "NCT06045156": {
    "title": "Early Tirofiban Administration After Intravenous Thrombolysis in Acute Ischemic Stroke",
    "status": "RECRUITING",
    "last": "2025-12-30",
    "results": false,
    "enroll": {
     "count": 1084,
     "type": "ESTIMATED"
    },
    "phase": [
     "NA"
    ],
    "resfirst": null,
    "completion": {
     "date": "2026-12-30",
     "type": "ESTIMATED"
    }
   },
   "NCT06146790": {
    "title": "Evaluation of Endovascular Treatment in Acute Intracranial Distal Medium Vessel Occlusion Stroke",
    "status": "UNKNOWN",
    "last": "2024-09-05",
    "results": false,
    "enroll": {
     "count": 564,
     "type": "ESTIMATED"
    },
    "phase": [
     "NA"
    ],
    "resfirst": null,
    "completion": {
     "date": "2026-03-01",
     "type": "ESTIMATED"
    }
   },
   "NCT06402968": {
    "title": "Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage",
    "status": "RECRUITING",
    "last": "2026-08-07",
    "results": false,
    "enroll": {
     "count": 1018,
     "type": "ESTIMATED"
    },
    "phase": null,
    "resfirst": null,
    "completion": {
     "date": "2028-07-30",
     "type": "ESTIMATED"
    }
   },
   "NCT06429332": {
    "title": "International Care Bundle Evaluation in Cerebral Hemorrhage Research",
    "status": "RECRUITING",
    "last": "2026-05-22",
    "results": false,
    "enroll": {
     "count": 3500,
     "type": "ESTIMATED"
    },
    "phase": [
     "PHASE4"
    ],
    "resfirst": null,
    "completion": {
     "date": "2027-07",
     "type": "ESTIMATED"
    }
   },
   "NCT06437431": {
    "title": "Glenzocimab in Anterior Stroke With Large Ischemic Core Eligible for Endovascular Therapy",
    "status": "WITHDRAWN",
    "last": "2026-09-09",
    "results": false,
    "enroll": {
     "count": 0,
     "type": "ACTUAL"
    },
    "phase": [
     "PHASE2",
     "PHASE3"
    ],
    "resfirst": null,
    "completion": {
     "date": "2030-10",
     "type": "ESTIMATED"
    }
   },
   "NCT06587737": {
    "title": "Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage",
    "status": "NOT_YET_RECRUITING",
    "last": "2026-09-01",
    "results": false,
    "enroll": {
     "count": 1125,
     "type": "ESTIMATED"
    },
    "phase": [
     "PHASE3"
    ],
    "resfirst": null,
    "completion": {
     "date": "2028-10-30",
     "type": "ESTIMATED"
    }
   },
   "NCT06604143": {
    "title": "Stroke Motor Recovery for the Hand and Fingers",
    "status": "RECRUITING",
    "last": "2026-05-08",
    "results": false,
    "enroll": {
     "count": 40,
     "type": "ESTIMATED"
    },
    "phase": [
     "NA"
    ],
    "resfirst": null,
    "completion": {
     "date": "2027-12-31",
     "type": "ESTIMATED"
    }
   },
   "NCT06760078": {
    "title": "Tranexamic Acid with Intensive Blood Pressure Management in Ultra-Early Intracerebral Hemorrhage",
    "status": "NOT_YET_RECRUITING",
    "last": "2025-01-07",
    "results": false,
    "enroll": {
     "count": 532,
     "type": "ESTIMATED"
    },
    "phase": [
     "PHASE4"
    ],
    "resfirst": null,
    "completion": {
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