Cole EJ, et al. Stanford Neuromodulation Therapy: a double-blind randomized controlled trial¶

One-paragraph summary¶

This small double-blind sham-controlled trial tested an accelerated, high-dose intermittent theta-burst course with individualized functional-connectivity targeting in treatment-resistant depression and found a large short-term benefit, following an earlier open-label report.

Key findings¶

Demonstrated controlled efficacy of the compressed SNT protocol.
Combined acceleration, high pulse dose, and individualized targeting.

Limitations¶

Small, single-center sample.
Component contribution, independent replication, and durability remain uncertain.

Why it matters¶

It made days-long personalized TMS a major replication and implementation target.

Cited by wiki pages¶

Neuromodulation
Overview