What's new — Degenerative disc disease¶
Generated 2026-09-03 from the publication dates of every paper cited in this condition's pages.
This page answers a different question from the curation log. The log says when we last edited a page; this says how recent the evidence on those pages is — so you can tell settled ground from a field that is actively moving, and jump straight to what has emerged lately.
How much of this condition's evidence is recent¶
| Published within | Cited papers |
|---|---|
| last week | 0 |
| last month | 0 |
| last 2 months | 0 |
| last 3 months | 2 |
| last 6 months | 7 |
| last year | 19 |
| older than a year | 329 |
Counts are cumulative: a paper from last week also counts inside "last month". Dates are PubMed publication or e-publication dates, so a paper may have appeared online before its journal issue.
Newest evidence first¶
The most recent cited papers, with the pages that use them.
| Published | Paper | Cited on |
|---|---|---|
| 2026-07-01 | Convergent validity and responsiveness of the 9-item PROMIS-29 derived low back pain impact score — J Pain ([PMID 42471169](https://pubmed.ncbi.nlm.nih.gov/42471169/){target="_blank" rel="noopener"}) | outcomes-and-measurement |
| 2026-07-01 | Total disc replacement versus lumbar interbody fusion for degenerative disc disease: a meta-analysis of randomized controlled trials — Neurosurg Focus ([PMID 42385251](https://pubmed.ncbi.nlm.nih.gov/42385251/){target="_blank" rel="noopener"}) | fusion-and-disc-replacement |
| 2026-06-01 | Effectiveness of telerehabilitation in managing chronic low back pain: a pragmatic randomized controlled non-inferiority trial — Int J Med Inform ([PMID 42284831](https://pubmed.ncbi.nlm.nih.gov/42284831/){target="_blank" rel="noopener"}) | clinical-trials-landscape |
| 2026-05-03 | MRI-based deep learning radiomics model for automated classification of disc degeneration in the lumbar spine — Sci Rep ([PMID 42218311](https://pubmed.ncbi.nlm.nih.gov/42218311/){target="_blank" rel="noopener"}) | biomarkers |
| 2026-05-02 | Modelling disc degeneration-induced neurovascular invasion on a chip for chronic low back pain therapeutic testing — Acta Biomater ([PMID 42178083](https://pubmed.ncbi.nlm.nih.gov/42178083/){target="_blank" rel="noopener"}) | cellular-and-molecular-degeneration |
| 2026-05-01 | Efficacy of Antibiotics for Chronic Low Back Pain With Disc Herniation: A Randomized Clinical Trial — JAMA Netw Open ([PMID 42149593](https://pubmed.ncbi.nlm.nih.gov/42149593/){target="_blank" rel="noopener"}) | injections-and-ablative-procedures |
| 2026-04-02 | Platelet-Rich Plasma vs. Mesenchymal Stem Cells for Lumbar Disc Degeneration: A Systematic Review and Meta-Analysis — Int J Mol Sci ([PMID 42123394](https://pubmed.ncbi.nlm.nih.gov/42123394/){target="_blank" rel="noopener"}) | clinical-trials-landscape |
| 2026-03-03 | Progression of lumbar disc degeneration: a 26-year follow-up study of healthy individuals from childhood to adulthood — Spine J ([PMID 41786224](https://pubmed.ncbi.nlm.nih.gov/41786224/){target="_blank" rel="noopener"}) | epidemiology-and-natural-history, genetics-and-environmental-risk, overview |
| 2026-02-02 | Mapping the degenerating intervertebral disc: a systematic review of histological evidence — Front Med (Lausanne) ([PMID 41822885](https://pubmed.ncbi.nlm.nih.gov/41822885/){target="_blank" rel="noopener"}) | cellular-and-molecular-degeneration |
| 2026-01-08 | Assessment of the content validity of the Oswestry Disability Index (ODI) in patients with Degenerative Disc Disease (DDD): a qualitative study — BMC Musculoskelet Disord ([PMID 41507883](https://pubmed.ncbi.nlm.nih.gov/41507883/){target="_blank" rel="noopener"}) | patient-experience-and-advocacy |
| 2025-12-03 | Mesenchymal Stromal Cells for the Treatment of Discogenic Low Back Pain: A Systematic Review of Clinical Studies — Neurospine ([PMID 41508590](https://pubmed.ncbi.nlm.nih.gov/41508590/){target="_blank" rel="noopener"}) | regenerative-and-biologic-therapy |
| 2025-12-03 | A Commentary on "Magnetic Resonance Spectroscopy Lipids Peak May Serve as a Potential Biomarker for Back Pain in Intervertebral Disc Degeneration: An Integrative Metabolomics and Proteomics Study Investigating the Role of the Lipid Droplets-Interleukin-17 Inflammatory Axis" — Neurospine ([PMID 41508583](https://pubmed.ncbi.nlm.nih.gov/41508583/){target="_blank" rel="noopener"}) | biomarkers |
| 2025-12-01 | Stem cell therapy for degenerative disc disease: A systematic review of preclinical evidence, clinical translation, and future directions — N Am Spine Soc J ([PMID 41608524](https://pubmed.ncbi.nlm.nih.gov/41608524/){target="_blank" rel="noopener"}) | clinical-trials-landscape |
| 2025-12-01 | Comprehensive Evidence-Based Guidelines for Regenerative Therapies in the Management of Chronic Low Back Pain: 2025 Update from the American Society Of Interventional Pain Physicians (ASIPP) — Pain Physician ([PMID 41481869](https://pubmed.ncbi.nlm.nih.gov/41481869/){target="_blank" rel="noopener"}) | guidelines |
| 2025-10-02 | Human molecular mechanisms of lumbar disc degeneration: A scoping review — Spine Open ([PMID 41585630](https://pubmed.ncbi.nlm.nih.gov/41585630/){target="_blank" rel="noopener"}) | nomenclature-and-diagnostic-validity |
| 2025-10-01 | Diagnostic Utility of Red Flags for Detecting Spinal Malignancies in Patients with Low Back Pain: A Scoping Review — J Clin Med ([PMID 41156041](https://pubmed.ncbi.nlm.nih.gov/41156041/){target="_blank" rel="noopener"}) | red-flags-and-safety-concerns |
| 2025-10-01 | Understanding the Microenvironment of Intervertebral Disc Degeneration: A Comprehensive Review of Pathophysiological Insights and Therapeutic Implications — Int J Mol Sci ([PMID 41155233](https://pubmed.ncbi.nlm.nih.gov/41155233/){target="_blank" rel="noopener"}) | cellular-and-molecular-degeneration |
| 2025-10-01 | From molecular regulation to tissue repair: hydrogels in the fight against intervertebral disc degeneration — Ann Med ([PMID 41084298](https://pubmed.ncbi.nlm.nih.gov/41084298/){target="_blank" rel="noopener"}) | clinical-trials-landscape, regenerative-and-biologic-therapy |
| 2025-09-08 | Patient selection, clinical outcomes, associated healthcare utilization, and cost-effectiveness of basivertebral nerve ablation for the treatment of vertebrogenic low back pain: A narrative review — N Am Spine Soc J ([PMID 41146940](https://pubmed.ncbi.nlm.nih.gov/41146940/){target="_blank" rel="noopener"}) | clinical-trials-landscape |
Trials — what has moved¶
48 registered trials are cited by this condition's pages. Registry records were re-checked live when this page was generated, so status, enrolment and results-posting below reflect ClinicalTrials.gov as of that date.
| Registry activity | Trials |
|---|---|
| trial records updated in the last week | 0 |
| trial records updated in the last month | 3 |
| trial records updated in the last 2 months | 5 |
| trial records updated in the last 3 months | 10 |
| trial records updated in the last 6 months | 16 |
| trial records updated in the last year | 24 |
Recently updated registrations¶
Posted efficacy and safety results¶
Trials whose sponsors have posted results to the registry. Adverse-event figures are participant counts summed across all arms as reported — read them against enrolment, and follow the registry link for the arm-by-arm breakdown that determines whether a signal is real.
| Results posted | Trial | Phase | N | Primary outcome | Serious AE | Other AE | Deaths |
|---|---|---|---|---|---|---|---|
| 2025-05-08 | CLBP Single-Arm Long-Term Follow-up Study | NA | 42 | Mean Change in ODI From Baseline to 5 Years Post Intracept Procedure | 0 | 0 | 0 |
| 2023-12-11 | Intradiscal Platelet Rich Plasma | PHASE4 | 3 | Numeric Rating Scale for Low Back Pain at 2-Month Follow-up | 0 | 0 | 0 |
| 2017-06-08 | Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symp | PHASE4 | 81 | Percent Change in Average Daily Pain Score | 0 | 0 | 0 |
| 2011-11-28 | Drug Use Survey (DUS) of Triple Therapy (Methycobal (MBL)+ Myonal (MYO | NA | 478 | Overall Satisfaction Degree After 2 Weeks Treatment of Triple Therapy | 0 | 13 | 0 |
22 of these trials are still recruiting or active — see the condition's clinical trials page for the full landscape.
Which pages rest on the newest evidence¶
🔥 marks a page citing three or more papers from the last year — the pages worth re-reading if you have been away.
| Page | Newest citation | In last year | Total citations |
|---|---|---|---|
| fusion-and-disc-replacement | 2026-07-01 | 1 | 32 |
| outcomes-and-measurement | 2026-07-01 | 1 | 31 |
| clinical-trials-landscape | 2026-06-01 | 5 | 32 |
| biomarkers | 2026-05-03 | 2 | 32 |
| cellular-and-molecular-degeneration | 2026-05-02 | 3 | 33 |
| injections-and-ablative-procedures | 2026-05-01 | 1 | 34 |
| epidemiology-and-natural-history | 2026-03-03 | 1 | 31 |
| genetics-and-environmental-risk | 2026-03-03 | 1 | 31 |
| overview | 2026-03-03 | 1 | 42 |
| patient-experience-and-advocacy | 2026-01-08 | 1 | 31 |
| regenerative-and-biologic-therapy | 2025-12-03 | 2 | 33 |
| guidelines | 2025-12-01 | 1 | 35 |
| nomenclature-and-diagnostic-validity | 2025-10-02 | 1 | 32 |
| red-flags-and-safety-concerns | 2025-10-01 | 1 | 31 |
| imaging-and-grading | 2025-09-01 | 0 | 31 |
| conservative-treatment | 2025-01-02 | 0 | 31 |
| disc-anatomy-and-biomechanics | 2024-10-08 | 0 | 31 |
| discogenic-pain-and-differential | 2024-05-01 | 0 | 31 |
Recency is not quality: an old paper may be the definitive one, and a new paper may not replicate. Use this to find movement, not to rank evidence. See open questions for what remains unresolved, and the curation log for when these pages were last revised.