What's new — Degenerative disc disease¶
Generated 2026-11-01 from the publication dates of every paper cited in this condition's pages.
This page answers a different question from the curation log. The log says when we last edited a page; this says how recent the evidence on those pages is — so you can tell settled ground from a field that is actively moving, and jump straight to what has emerged lately.
How much of this condition's evidence is recent¶
| Published within | Cited papers |
|---|---|
| last week | 0 |
| last month | 3 |
| last 2 months | 8 |
| last 3 months | 9 |
| last 6 months | 15 |
| last year | 25 |
| older than a year | 334 |
Counts are cumulative: a paper from last week also counts inside "last month". Dates are PubMed publication or e-publication dates, so a paper may have appeared online before its journal issue.
Newest evidence first¶
The most recent cited papers, with the pages that use them.
| Published | Paper | Cited on |
|---|---|---|
| 2026-10-09 | Preparation methods and clinical outcomes of platelet-rich plasma for chronic discogenic low back pain: A systematic review and meta-analysis of randomized controlled trials — PM R ([PMID 42852874](https://pubmed.ncbi.nlm.nih.gov/42852874/){target="_blank" rel="noopener"}) | guidelines, injections-and-ablative-procedures, regenerative-and-biologic-therapy |
| 2026-10-02 | Cost-effectiveness of recommended interventions for managing low back pain: A systematic review — PLoS Med ([PMID 42945153](https://pubmed.ncbi.nlm.nih.gov/42945153/){target="_blank" rel="noopener"}) | guidelines |
| 2026-10-02 | The ISSLS VERTEBRA initiative: establishing reporting standards for regenerative medicine trials in disc degeneration and low back pain — Eur Spine J ([PMID 42900386](https://pubmed.ncbi.nlm.nih.gov/42900386/){target="_blank" rel="noopener"}) | regenerative-and-biologic-therapy |
| 2026-10-01 | Pain Coping Strategies Among Adult Patients with Degenerative Disc Disease — J Clin Med ([PMID 42941526](https://pubmed.ncbi.nlm.nih.gov/42941526/){target="_blank" rel="noopener"}) | patient-experience-and-advocacy |
| 2026-09-02 | Optimal exercise dose in adults with chronic low back pain disorders: systematic review with dose-response network meta-analysis — Br J Sports Med ([PMID 42785965](https://pubmed.ncbi.nlm.nih.gov/42785965/){target="_blank" rel="noopener"}) | conservative-treatment |
| 2026-09-02 | Assessment and Treatment of Acute Low Back Pain: A Multidisciplinary Clinical Practice Guideline — Pain Med ([PMID 42687437](https://pubmed.ncbi.nlm.nih.gov/42687437/){target="_blank" rel="noopener"}) | guidelines |
| 2026-09-01 | Regenerative Therapies in the Management of Chronic Low Back Pain from Evidence to Practice: An Analytical Summary of the 2025 Comprehensive Evidence-Based Guidelines — Pain Physician ([PMID 42804305](https://pubmed.ncbi.nlm.nih.gov/42804305/){target="_blank" rel="noopener"}) | guidelines |
| 2026-09-01 | Analysis of Complications Associated with Basivertebral Nerve Ablation for Vertebrogenic Low Back Pain: A Multicenter Retrospective Cohort Study of 1,145 Patients — Pain Med ([PMID 42765343](https://pubmed.ncbi.nlm.nih.gov/42765343/){target="_blank" rel="noopener"}) | injections-and-ablative-procedures |
| 2026-08-02 | Multidisciplinary expert consensus on clinical diagnosis and therapies for low back pain — Bone Res ([PMID 42660880](https://pubmed.ncbi.nlm.nih.gov/42660880/){target="_blank" rel="noopener"}) | guidelines, injections-and-ablative-procedures |
| 2026-07-09 | Adverse events associated with basivertebral nerve radiofrequency ablation: A comprehensive analysis from the MAUDE database — Interv Pain Med ([PMID 42473615](https://pubmed.ncbi.nlm.nih.gov/42473615/){target="_blank" rel="noopener"}) | injections-and-ablative-procedures |
| 2026-07-02 | Pamidronate is ineffective for inflammatory-like low back pain associated with Modic type 1 changes: A double-blind, randomised controlled trial — Osteoarthr Cartil Open ([PMID 42569384](https://pubmed.ncbi.nlm.nih.gov/42569384/){target="_blank" rel="noopener"}) | conservative-treatment |
| 2026-07-01 | Convergent validity and responsiveness of the 9-item PROMIS-29 derived low back pain impact score — J Pain ([PMID 42471169](https://pubmed.ncbi.nlm.nih.gov/42471169/){target="_blank" rel="noopener"}) | outcomes-and-measurement |
| 2026-07-01 | Total disc replacement versus lumbar interbody fusion for degenerative disc disease: a meta-analysis of randomized controlled trials — Neurosurg Focus ([PMID 42385251](https://pubmed.ncbi.nlm.nih.gov/42385251/){target="_blank" rel="noopener"}) | fusion-and-disc-replacement |
| 2026-06-01 | Effectiveness of telerehabilitation in managing chronic low back pain: a pragmatic randomized controlled non-inferiority trial — Int J Med Inform ([PMID 42284831](https://pubmed.ncbi.nlm.nih.gov/42284831/){target="_blank" rel="noopener"}) | clinical-trials-landscape |
| 2026-05-03 | MRI-based deep learning radiomics model for automated classification of disc degeneration in the lumbar spine — Sci Rep ([PMID 42218311](https://pubmed.ncbi.nlm.nih.gov/42218311/){target="_blank" rel="noopener"}) | biomarkers |
| 2026-05-02 | Modelling disc degeneration-induced neurovascular invasion on a chip for chronic low back pain therapeutic testing — Acta Biomater ([PMID 42178083](https://pubmed.ncbi.nlm.nih.gov/42178083/){target="_blank" rel="noopener"}) | cellular-and-molecular-degeneration |
| 2026-05-01 | Efficacy of Antibiotics for Chronic Low Back Pain With Disc Herniation: A Randomized Clinical Trial — JAMA Netw Open ([PMID 42149593](https://pubmed.ncbi.nlm.nih.gov/42149593/){target="_blank" rel="noopener"}) | injections-and-ablative-procedures |
| 2026-04-02 | Platelet-Rich Plasma vs. Mesenchymal Stem Cells for Lumbar Disc Degeneration: A Systematic Review and Meta-Analysis — Int J Mol Sci ([PMID 42123394](https://pubmed.ncbi.nlm.nih.gov/42123394/){target="_blank" rel="noopener"}) | clinical-trials-landscape |
| 2026-03-03 | Progression of lumbar disc degeneration: a 26-year follow-up study of healthy individuals from childhood to adulthood — Spine J ([PMID 41786224](https://pubmed.ncbi.nlm.nih.gov/41786224/){target="_blank" rel="noopener"}) | epidemiology-and-natural-history, genetics-and-environmental-risk, overview |
| 2026-02-02 | Mapping the degenerating intervertebral disc: a systematic review of histological evidence — Front Med (Lausanne) ([PMID 41822885](https://pubmed.ncbi.nlm.nih.gov/41822885/){target="_blank" rel="noopener"}) | cellular-and-molecular-degeneration |
| 2026-01-08 | Assessment of the content validity of the Oswestry Disability Index (ODI) in patients with Degenerative Disc Disease (DDD): a qualitative study — BMC Musculoskelet Disord ([PMID 41507883](https://pubmed.ncbi.nlm.nih.gov/41507883/){target="_blank" rel="noopener"}) | patient-experience-and-advocacy |
| 2025-12-03 | Mesenchymal Stromal Cells for the Treatment of Discogenic Low Back Pain: A Systematic Review of Clinical Studies — Neurospine ([PMID 41508590](https://pubmed.ncbi.nlm.nih.gov/41508590/){target="_blank" rel="noopener"}) | regenerative-and-biologic-therapy |
| 2025-12-03 | A Commentary on "Magnetic Resonance Spectroscopy Lipids Peak May Serve as a Potential Biomarker for Back Pain in Intervertebral Disc Degeneration: An Integrative Metabolomics and Proteomics Study Investigating the Role of the Lipid Droplets-Interleukin-17 Inflammatory Axis" — Neurospine ([PMID 41508583](https://pubmed.ncbi.nlm.nih.gov/41508583/){target="_blank" rel="noopener"}) | biomarkers |
| 2025-12-01 | Stem cell therapy for degenerative disc disease: A systematic review of preclinical evidence, clinical translation, and future directions — N Am Spine Soc J ([PMID 41608524](https://pubmed.ncbi.nlm.nih.gov/41608524/){target="_blank" rel="noopener"}) | clinical-trials-landscape |
| 2025-12-01 | Comprehensive Evidence-Based Guidelines for Regenerative Therapies in the Management of Chronic Low Back Pain: 2025 Update from the American Society Of Interventional Pain Physicians (ASIPP) — Pain Physician ([PMID 41481869](https://pubmed.ncbi.nlm.nih.gov/41481869/){target="_blank" rel="noopener"}) | guidelines |
Trials — what has moved¶
54 registered trials are cited by this condition's pages. Registry records were re-checked live when this page was generated, so status, enrolment and results-posting below reflect ClinicalTrials.gov as of that date.
| Registry activity | Trials |
|---|---|
| trial records updated in the last week | 1 |
| trial records updated in the last month | 6 |
| trial records updated in the last 2 months | 11 |
| trial records updated in the last 3 months | 13 |
| trial records updated in the last 6 months | 18 |
| trial records updated in the last year | 28 |
Recently updated registrations¶
Posted efficacy and safety results¶
Trials whose sponsors have posted results to the registry. Adverse-event figures are participant counts summed across all arms as reported — read them against enrolment, and follow the registry link for the arm-by-arm breakdown that determines whether a signal is real.
| Results posted | Trial | Phase | N | Primary outcome | Serious AE | Other AE | Deaths |
|---|---|---|---|---|---|---|---|
| 2025-05-08 | CLBP Single-Arm Long-Term Follow-up Study | NA | 42 | Mean Change in ODI From Baseline to 5 Years Post Intracept Procedure | 0 | 0 | 0 |
| 2023-12-11 | Intradiscal Platelet Rich Plasma | PHASE4 | 3 | Numeric Rating Scale for Low Back Pain at 2-Month Follow-up | 0 | 0 | 0 |
| 2017-06-08 | Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symp | PHASE4 | 81 | Percent Change in Average Daily Pain Score | 0 | 0 | 0 |
| 2011-11-28 | Drug Use Survey (DUS) of Triple Therapy (Methycobal (MBL)+ Myonal (MYO | NA | 478 | Overall Satisfaction Degree After 2 Weeks Treatment of Triple Therapy | 0 | 13 | 0 |
27 of these trials are still recruiting or active — see the condition's clinical trials page for the full landscape.
Which pages rest on the newest evidence¶
🔥 marks a page citing three or more papers from the last year — the pages worth re-reading if you have been away.
| Page | Newest citation | In last year | Total citations |
|---|---|---|---|
| guidelines | 2026-10-09 | 6 | 40 |
| injections-and-ablative-procedures | 2026-10-09 | 5 | 38 |
| regenerative-and-biologic-therapy | 2026-10-09 | 3 | 35 |
| patient-experience-and-advocacy | 2026-10-01 | 2 | 32 |
| conservative-treatment | 2026-09-02 | 2 | 33 |
| fusion-and-disc-replacement | 2026-07-01 | 1 | 32 |
| outcomes-and-measurement | 2026-07-01 | 1 | 31 |
| clinical-trials-landscape | 2026-06-01 | 3 | 32 |
| biomarkers | 2026-05-03 | 2 | 32 |
| cellular-and-molecular-degeneration | 2026-05-02 | 2 | 33 |
| epidemiology-and-natural-history | 2026-03-03 | 1 | 31 |
| genetics-and-environmental-risk | 2026-03-03 | 1 | 31 |
| overview | 2026-03-03 | 1 | 42 |
| nomenclature-and-diagnostic-validity | 2025-10-02 | 0 | 32 |
| red-flags-and-safety-concerns | 2025-10-01 | 0 | 31 |
| imaging-and-grading | 2025-09-01 | 0 | 31 |
| disc-anatomy-and-biomechanics | 2024-10-08 | 0 | 31 |
| discogenic-pain-and-differential | 2024-05-01 | 0 | 31 |
Recency is not quality: an old paper may be the definitive one, and a new paper may not replicate. Use this to find movement, not to rank evidence. See open questions for what remains unresolved, and the curation log for when these pages were last revised.