Skip to content

Albert 2016 — LOTT oxygen trial

One-paragraph summary

LOTT randomized stable COPD with moderate resting desaturation or exercise-induced moderate desaturation to long-term supplemental oxygen or no long-term oxygen. It found no significant improvement in time to death or first hospitalization, constraining extension of older severe-hypoxemia evidence to moderate desaturation (PMID 27783918).

Key findings

  • No benefit for the composite of death or first hospitalization.
  • The trial directly addressed a common extrapolation beyond classic LTOT eligibility.

Limitations

  • Does not test severe resting hypoxemia.
  • Does not exclude short-term exercise-test benefit for an individual.

Why it matters

It established a quantitative boundary around routine oxygen prescribing.

Cited by wiki pages

  • Overview
  • Oxygen and ventilatory support
  • Guidelines