What's new — Bipolar disorder¶
Generated 2026-11-01 from the publication dates of every paper cited in this condition's pages.
This page answers a different question from the curation log. The log says when we last edited a page; this says how recent the evidence on those pages is — so you can tell settled ground from a field that is actively moving, and jump straight to what has emerged lately.
How much of this condition's evidence is recent¶
| Published within | Cited papers |
|---|---|
| last week | 5 |
| last month | 12 |
| last 2 months | 27 |
| last 3 months | 32 |
| last 6 months | 46 |
| last year | 55 |
| older than a year | 368 |
Counts are cumulative: a paper from last week also counts inside "last month". Dates are PubMed publication or e-publication dates, so a paper may have appeared online before its journal issue.
Newest evidence first¶
The most recent cited papers, with the pages that use them.
| Published | Paper | Cited on |
|---|---|---|
| 2026-11-01 | Women With Bipolar Disorder are at Increased Risk of Sarcopenia — Bipolar Disord ([PMID 42897866](https://pubmed.ncbi.nlm.nih.gov/42897866/){target="_blank" rel="noopener"}) | suicide-mortality-and-physical-health |
| 2026-11-01 | Bipolar Disorder and Perimenopause: An Update — Bipolar Disord ([PMID 42811911](https://pubmed.ncbi.nlm.nih.gov/42811911/){target="_blank" rel="noopener"}) | pregnancy-and-reproductive-health |
| 2026-11-01 | Tirzepatide Initiation in Lithium-Treated Bipolar Disorder: Renal Biomarker Trajectories and Lithium Safety Signals Over 12 Months in a Real-World Cohort — Hum Psychopharmacol ([PMID 42803597](https://pubmed.ncbi.nlm.nih.gov/42803597/){target="_blank" rel="noopener"}) | lithium |
| 2026-11-01 | Comparative Effectiveness of Lithium- Vs. Valproate-Based Combinations With Atypical Antipsychotics in Preventing Rehospitalization After a First Manic Episode of Bipolar I Disorder — Bipolar Disord ([PMID 42765449](https://pubmed.ncbi.nlm.nih.gov/42765449/){target="_blank" rel="noopener"}) | maintenance-and-relapse-prevention |
| 2026-11-01 | Association Between Lithium Use and Suicide-Related Behaviors in Bipolar Disorder: A Multicenter Study — Bipolar Disord ([PMID 42713736](https://pubmed.ncbi.nlm.nih.gov/42713736/){target="_blank" rel="noopener"}) | suicide-mortality-and-physical-health |
| 2026-10-09 | Contraceptive use in women of childbearing age with bipolar disorder — BMC Psychiatry ([PMID 42850618](https://pubmed.ncbi.nlm.nih.gov/42850618/){target="_blank" rel="noopener"}) | pregnancy-and-reproductive-health |
| 2026-10-08 | Copeptin and urine concentrating capacity predict kidney function decline in lithium-treated patients — Nephrol Dial Transplant ([PMID 42847926](https://pubmed.ncbi.nlm.nih.gov/42847926/){target="_blank" rel="noopener"}) | lithium |
| 2026-10-07 | Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder — Br J Psychiatry ([PMID 42841250](https://pubmed.ncbi.nlm.nih.gov/42841250/){target="_blank" rel="noopener"}) | lithium |
| 2026-10-06 | Cannabis use and subsequent onset of manic symptoms and bipolar disorder: A systematic review and meta-analysis — J Affect Disord ([PMID 42838231](https://pubmed.ncbi.nlm.nih.gov/42838231/){target="_blank" rel="noopener"}) | comorbidity-and-differential-diagnosis |
| 2026-10-05 | EDIT-B consortium: an external pan-European validation of an innovative machine learning-based test for bipolar disorder diagnosis — BMJ Ment Health ([PMID 42833865](https://pubmed.ncbi.nlm.nih.gov/42833865/){target="_blank" rel="noopener"}) | biomarkers-and-digital-phenotyping |
| 2026-10-02 | Bipolar Disorder and the Risk of Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Observational Studies — Acta Psychiatr Scand ([PMID 42902526](https://pubmed.ncbi.nlm.nih.gov/42902526/){target="_blank" rel="noopener"}) | suicide-mortality-and-physical-health |
| 2026-10-02 | Meta-Analytic Evidence of Clinical, Cognitive, Biological and Treatment Characteristics of Bipolar Spectrum Disorder in Children and Adolescents: Results From an Umbrella Review — J Am Acad Child Adolesc Psychiatry ([PMID 42901238](https://pubmed.ncbi.nlm.nih.gov/42901238/){target="_blank" rel="noopener"}) | suicide-mortality-and-physical-health |
| 2026-10-01 | Ethnic disparities in time to bipolar disorder diagnosis: retrospective cohort study — BJPsych Open ([PMID 42894408](https://pubmed.ncbi.nlm.nih.gov/42894408/){target="_blank" rel="noopener"}) | epidemiology-and-course |
| 2026-10-01 | Network analysis of the genetic relationships between twenty psychiatric and substance use disorders — World Psychiatry ([PMID 42742582](https://pubmed.ncbi.nlm.nih.gov/42742582/){target="_blank" rel="noopener"}) | genetics-and-neurobiology |
| 2026-10-01 | Comparative effectiveness of mood stabiliser monotherapy versus second-generation antipsychotic monotherapy versus combination therapy for continuation and maintenance treatment after a first episode of psychotic mania in North America, Chile, and Spain: a target trial emulation using data from the BD-CAUSAL Collaboration — Lancet Psychiatry ([PMID 42716056](https://pubmed.ncbi.nlm.nih.gov/42716056/){target="_blank" rel="noopener"}) | maintenance-and-relapse-prevention |
| 2026-09-09 | Comparison of Long-Acting Injectable and Oral Antipsychotics in Bipolar Disorder — Am J Psychiatry ([PMID 42711749](https://pubmed.ncbi.nlm.nih.gov/42711749/){target="_blank" rel="noopener"}) | maintenance-and-relapse-prevention |
| 2026-09-07 | Predicting SILENT after lithium poisoning: a multicenter cohort study and pragmatic risk stratification model — Clin Toxicol (Phila) ([PMID 42703744](https://pubmed.ncbi.nlm.nih.gov/42703744/){target="_blank" rel="noopener"}) | lithium |
| 2026-09-06 | Cardiorespiratory fitness in people with bipolar disorder: A systematic review and meta-analysis — J Affect Disord ([PMID 42702273](https://pubmed.ncbi.nlm.nih.gov/42702273/){target="_blank" rel="noopener"}) | suicide-mortality-and-physical-health |
| 2026-09-03 | Pharmacological interventions for acute major depression and bipolar depression with mixed features: A systematic review and dose-related network meta-analysis across different age groups — J Affect Disord ([PMID 42815730](https://pubmed.ncbi.nlm.nih.gov/42815730/){target="_blank" rel="noopener"}) | bipolar-depression |
| 2026-09-02 | Association of lithium versus valproate initiation with all-cause mortality and incident dementia: a multinational real-world cohort study — Front Neurol ([PMID 42839929](https://pubmed.ncbi.nlm.nih.gov/42839929/){target="_blank" rel="noopener"}) | lithium |
| 2026-09-02 | Effects of Lithium Treatment on Renal Function in Bipolar Disorder: A Retrospective Cohort Study — Psychiatry Res ([PMID 42810282](https://pubmed.ncbi.nlm.nih.gov/42810282/){target="_blank" rel="noopener"}) | lithium |
| 2026-09-02 | Correction to "Practice Guidelines for Bipolar Disorder by the JSMD (Japanese Society of Mood Disorders)" — Psychiatry Clin Neurosci ([PMID 42768410](https://pubmed.ncbi.nlm.nih.gov/42768410/){target="_blank" rel="noopener"}) | guidelines |
| 2026-09-02 | An Open-Label, Dose-Escalation Trial of Psilocybin-Assisted Therapy for Bipolar II Depression — J Clin Psychiatry ([PMID 42765891](https://pubmed.ncbi.nlm.nih.gov/42765891/){target="_blank" rel="noopener"}) | clinical-trials-landscape |
| 2026-09-02 | Comparing lithium and valproate in reducing suicide risk: A territory-wide retrospective cohort study with pairwise and network meta-analysis — Psychol Med ([PMID 42765379](https://pubmed.ncbi.nlm.nih.gov/42765379/){target="_blank" rel="noopener"}) | suicide-mortality-and-physical-health |
| 2026-09-02 | Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression: A Randomized Clinical Trial — JAMA Psychiatry ([PMID 42684694](https://pubmed.ncbi.nlm.nih.gov/42684694/){target="_blank" rel="noopener"}) | bipolar-depression, clinical-trials-landscape, guidelines |
| 2026-09-01 | Psychotic and bipolar disorder diagnoses following contact with child and adolescent mental health services-a longitudinal, nationwide register study of 2 million individuals — J Child Psychol Psychiatry ([PMID 42753132](https://pubmed.ncbi.nlm.nih.gov/42753132/){target="_blank" rel="noopener"}) | epidemiology-and-course |
| 2026-09-01 | Comparative Analysis of the Burden of Bipolar Disorder Among Individuals Aged 15-49 Years in China and Globally, 1990-2021: An Ecological Trend Analysis Based on GBD 2021 — Health Sci Rep ([PMID 42688390](https://pubmed.ncbi.nlm.nih.gov/42688390/){target="_blank" rel="noopener"}) | epidemiology-and-course |
| 2026-08-03 | Reducing the risk of obesity, diabetes, and metabolic disorders in patients treated with antipsychotics - recommendations of the Polish Psychiatric Association Part II: diagnostics and pharmacological treatment — Psychiatr Pol ([PMID 42857934](https://pubmed.ncbi.nlm.nih.gov/42857934/){target="_blank" rel="noopener"}) | guidelines |
| 2026-08-03 | Reducing the risk of obesity, diabetes, and metabolic disorders in patients treated with antipsychotics - recommendations of the Polish Psychiatric Association Part I: risk factors and psychological interventions — Psychiatr Pol ([PMID 42857933](https://pubmed.ncbi.nlm.nih.gov/42857933/){target="_blank" rel="noopener"}) | guidelines |
| 2026-08-03 | Retinal electrophysiology in mood disorders: Toward clinically relevant biomarkers. A systematic review and meta-analysis — J Affect Disord ([PMID 42669383](https://pubmed.ncbi.nlm.nih.gov/42669383/){target="_blank" rel="noopener"}) | biomarkers-and-digital-phenotyping |
| 2026-08-02 | Examination of the intersection of bipolar I disorder status and cannabis use disorder severity in relation to health-related quality-of-life and lifetime suicide attempts — J Psychiatr Res ([PMID 42664567](https://pubmed.ncbi.nlm.nih.gov/42664567/){target="_blank" rel="noopener"}) | suicide-mortality-and-physical-health |
| 2026-08-02 | Higher frequencies of CNV deletions in bipolar disorder among Chinese Population — Mol Psychiatry ([PMID 42661060](https://pubmed.ncbi.nlm.nih.gov/42661060/){target="_blank" rel="noopener"}) | genetics-and-neurobiology |
| 2026-08-01 | Therapeutic strategies after discontinuation of valproate in females of child-bearing potential with bipolar disorder: an insurance claims database study in France and the United Kingdom — Psychiatry Res ([PMID 42700484](https://pubmed.ncbi.nlm.nih.gov/42700484/){target="_blank" rel="noopener"}) | pregnancy-and-reproductive-health |
| 2026-08-01 | Association of Lithium Use With Suicide and Self-Harm Among Chinese Adolescents and Adults With Bipolar Disorder: A Nationwide Multicenter Retrospective Cohort Study — J Clin Psychiatry ([PMID 42671279](https://pubmed.ncbi.nlm.nih.gov/42671279/){target="_blank" rel="noopener"}) | suicide-mortality-and-physical-health |
| 2026-08-01 | Risk of heart failure in patients with schizophrenia or bipolar disorder: A systematic review and meta-analysis — Pak J Med Sci ([PMID 42668911](https://pubmed.ncbi.nlm.nih.gov/42668911/){target="_blank" rel="noopener"}) | suicide-mortality-and-physical-health |
| 2026-08-01 | Sedentary Behavior and Physical Activity in Individuals With Bipolar Disorder: An Evidence Synthesis and Position Statement From the ISBD Nutrition and Exercise Task Force (NExT) — Bipolar Disord ([PMID 42545207](https://pubmed.ncbi.nlm.nih.gov/42545207/){target="_blank" rel="noopener"}) | guidelines, suicide-mortality-and-physical-health |
| 2026-08-01 | Cause-specific mortality due to physical illness in severe mental disorders in Europe: a population-based multi-country cohort study — Lancet Public Health ([PMID 42480565](https://pubmed.ncbi.nlm.nih.gov/42480565/){target="_blank" rel="noopener"}) | suicide-mortality-and-physical-health |
| 2026-08-01 | Correction to "Defining Treatment-Resistant Bipolar Depression: Recommendations From the ISBD Task Force" — Bipolar Disord ([PMID 42478728](https://pubmed.ncbi.nlm.nih.gov/42478728/){target="_blank" rel="noopener"}) | guidelines |
| 2026-08-01 | Towards a Safe and Effective Lithium Therapeutic Range for Older Adults With Bipolar Disorder: An ISBD Task Force Systematic Review — Bipolar Disord ([PMID 42460615](https://pubmed.ncbi.nlm.nih.gov/42460615/){target="_blank" rel="noopener"}) | guidelines, lithium |
| 2026-08-01 | Essential Information About Chronobiology and Chronotherapy for the Optimal Care of People With Bipolar Disorders: An Expert Consensus — Bipolar Disord ([PMID 42429210](https://pubmed.ncbi.nlm.nih.gov/42429210/){target="_blank" rel="noopener"}) | guidelines |
| 2026-08-01 | Towards an Integrated Staging Model for Bipolar Disorders: An International Society for Bipolar Disorders (ISBD) Staging Task Force Consensus Report — Bipolar Disord ([PMID 42310905](https://pubmed.ncbi.nlm.nih.gov/42310905/){target="_blank" rel="noopener"}) | guidelines |
| 2026-07-01 | An international initiative to implement recommendations for a lower therapeutic range of maintenance lithium in older adults with bipolar disorder — Curr Opin Psychiatry ([PMID 42489486](https://pubmed.ncbi.nlm.nih.gov/42489486/){target="_blank" rel="noopener"}) | guidelines |
| 2026-06-02 | Circadian Rhythm Stabilization App to Prevent Mood Episode Recurrence in Patients With Mood Disorders: A Multicenter, Double-Blind, Sham-Controlled, Randomized Clinical Trial — Am J Psychiatry ([PMID 42337416](https://pubmed.ncbi.nlm.nih.gov/42337416/){target="_blank" rel="noopener"}) | biomarkers-and-digital-phenotyping, psychotherapy-and-self-management |
| 2026-06-02 | Recommendations for Research and Clinical Implementation of Ambulatory Assessment, Mood Monitoring, Digital Phenotyping, and Remote Measurement Technology in Mood Disorders: Synthesis of Systematic Review Findings — JMIR Ment Health ([PMID 42228842](https://pubmed.ncbi.nlm.nih.gov/42228842/){target="_blank" rel="noopener"}) | biomarkers-and-digital-phenotyping |
| 2026-06-01 | Advancing Brain and Body Vascular Imaging in Bipolar Disorder: A Report From the International Society for Bipolar Disorders Vascular Task Force — Bipolar Disord ([PMID 42249599](https://pubmed.ncbi.nlm.nih.gov/42249599/){target="_blank" rel="noopener"}) | guidelines |
| 2026-05-09 | Digital phenotyping for predicting relapse in psychiatric disorders: a systematic review of passive sensing approaches — BMC Psychiatry ([PMID 42106724](https://pubmed.ncbi.nlm.nih.gov/42106724/){target="_blank" rel="noopener"}) | biomarkers-and-digital-phenotyping |
| 2026-05-02 | White matter microstructure in relatives of people with schizophrenia or bipolar disorder: an ENIGMA meta-analysis — Mol Psychiatry ([PMID 42168580](https://pubmed.ncbi.nlm.nih.gov/42168580/){target="_blank" rel="noopener"}) | biomarkers-and-digital-phenotyping |
| 2026-04-03 | The proportion of people with primary affective disorders presenting to early intervention services: systematic review and meta-analysis — Br J Psychiatry ([PMID 42057639](https://pubmed.ncbi.nlm.nih.gov/42057639/){target="_blank" rel="noopener"}) | comorbidity-and-differential-diagnosis |
| 2026-03-02 | The effect of smartphone-based monitoring and treatment including clinical feedback in progressed bipolar disorder: the SmartBipolar trial randomised controlled parallel-group trial — Int J Bipolar Disord ([PMID 41865316](https://pubmed.ncbi.nlm.nih.gov/41865316/){target="_blank" rel="noopener"}) | biomarkers-and-digital-phenotyping, psychotherapy-and-self-management |
| 2026-02-01 | Lithium nephrotoxicity: a systematic review and meta-analysis of lithium versus non-lithium control studies in patients with affective disorders — Ther Adv Psychopharmacol ([PMID 41727809](https://pubmed.ncbi.nlm.nih.gov/41727809/){target="_blank" rel="noopener"}) | lithium |
| 2026-01-07 | Mood Monitoring, Mood Tracking, and Ambulatory Assessment Interventions in Depression and Bipolar Disorder: Systematic Review and Meta-Analysis of Randomized Controlled Trials — JMIR Ment Health ([PMID 41499681](https://pubmed.ncbi.nlm.nih.gov/41499681/){target="_blank" rel="noopener"}) | biomarkers-and-digital-phenotyping, psychotherapy-and-self-management |
| 2026-01-02 | Clinical practice guidelines for the management of bipolar disorder: 2025 update — Indian J Psychiatry ([PMID 41694044](https://pubmed.ncbi.nlm.nih.gov/41694044/){target="_blank" rel="noopener"}) | guidelines |
| 2025-12-02 | Mixed features in depressive and bipolar disorders: An updated systematic review — J Affect Disord ([PMID 41448395](https://pubmed.ncbi.nlm.nih.gov/41448395/){target="_blank" rel="noopener"}) | diagnosis-and-bipolar-spectrum |
| 2025-12-01 | Longitudinal associations of electroconvulsive therapy with all-cause mortality and suicide deaths in severe unipolar or bipolar depression: a systematic review and meta-analysis — BMJ Ment Health ([PMID 41407487](https://pubmed.ncbi.nlm.nih.gov/41407487/){target="_blank" rel="noopener"}) | bipolar-depression |
| 2025-11-01 | Occurrence of Psychosis and Bipolar Disorder in Individuals With Attention-Deficit/Hyperactivity Disorder Treated With Stimulants: A Systematic Review and Meta-Analysis — JAMA Psychiatry ([PMID 40900605](https://pubmed.ncbi.nlm.nih.gov/40900605/){target="_blank" rel="noopener"}) | comorbidity-and-differential-diagnosis |
Trials — what has moved¶
40 registered trials are cited by this condition's pages. Registry records were re-checked live when this page was generated, so status, enrolment and results-posting below reflect ClinicalTrials.gov as of that date.
| Registry activity | Trials |
|---|---|
| trial records updated in the last week | 1 |
| trial records updated in the last month | 10 |
| trial records updated in the last 2 months | 14 |
| trial records updated in the last 3 months | 21 |
| trial records updated in the last 6 months | 25 |
| trial records updated in the last year | 35 |
Recently updated registrations¶
36 of these trials are still recruiting or active — see the condition's clinical trials page for the full landscape.
Which pages rest on the newest evidence¶
🔥 marks a page citing three or more papers from the last year — the pages worth re-reading if you have been away.
| Page | Newest citation | In last year | Total citations |
|---|---|---|---|
| lithium | 2026-11-01 | 8 | 28 |
| maintenance-and-relapse-prevention | 2026-11-01 | 3 | 23 |
| pregnancy-and-reproductive-health | 2026-11-01 | 3 | 28 |
| suicide-mortality-and-physical-health | 2026-11-01 | 11 | 38 |
| comorbidity-and-differential-diagnosis | 2026-10-06 | 3 | 28 |
| biomarkers-and-digital-phenotyping | 2026-10-05 | 8 | 40 |
| epidemiology-and-course | 2026-10-01 | 3 | 33 |
| genetics-and-neurobiology | 2026-10-01 | 2 | 27 |
| bipolar-depression | 2026-09-03 | 3 | 26 |
| clinical-trials-landscape | 2026-09-02 | 2 | 20 |
| guidelines | 2026-09-02 | 12 | 45 |
| psychotherapy-and-self-management | 2026-06-02 | 3 | 28 |
| diagnosis-and-bipolar-spectrum | 2025-12-02 | 1 | 31 |
| patient-experience-and-advocacy | 2025-10-01 | 0 | 23 |
| antidepressant-controversy | 2025-08-07 | 0 | 20 |
| mania-and-mixed-states | 2025-08-01 | 0 | 20 |
| overview | 2025-05-02 | 0 | 30 |
| red-flags-and-safety-concerns | 2024-06-03 | 0 | 30 |
Recency is not quality: an old paper may be the definitive one, and a new paper may not replicate. Use this to find movement, not to rank evidence. See open questions for what remains unresolved, and the curation log for when these pages were last revised.