Bipolar disorder — master bibliography

Every PMID cited anywhere in the bipolar-disorder condition appears in this bibliography. The 304-record audited set was expanded on 2026-09-03 with page-specific trials, syntheses, mechanistic studies, guideline documents and lived-experience evidence; four earlier sweep-context records cited only in LOG.md were also reconciled. The bibliography now contains 393 distinct live-resolved PubMed records. Records are grouped by primary topic; cited by lists wiki pages or literature-layer files that use the paper.

Diagnosis and bipolar spectrum

• Amerio A, et al. Diagnostic validity of comorbid bipolar disorder and obsessive-compulsive disorder: a systematic review. Acta Psychiatr Scand. 2014;129:343–358. PMID 24506190 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Angst J, et al. Diagnostic issues in bipolar disorder. Eur Neuropsychopharmacol. 2003;13 Suppl 2:S43–S50. PMID 12957719 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Benazzi F, et al. Bipolar II disorder: epidemiology, diagnosis and management. CNS Drugs. 2007;21:727–740. PMID 17696573 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Chakrabarti S, et al. Bipolar disorder in ICD-11: a review of the changes, their basis, and usefulness. World J Psychiatry. 2022;12:1335–1355. PMID 36579354 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Ducharme S, et al. Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders. Brain. 2020;143:1632–1650. PMID 32129844 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Dunalska A, et al. Comorbidity of bipolar disorder and autism spectrum disorder. Psychiatr Pol. 2021;55:1421–1431. PMID 35472236 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Frey BN, et al. Sensitivity and specificity of the Mood Disorder Questionnaire during pregnancy and the postpartum period. J Clin Psychiatry. 2012;73:1456–1461. PMID 23146292 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Grasso V, et al. Mixed features in depressive and bipolar disorders: an updated systematic review. J Affect Disord. 2026;398:120929. PMID 41448395 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Hirschfeld RM, et al. Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire. Am J Psychiatry. 2000;157:1873–1875. PMID 11058490 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Koukopoulos A, et al. DSM-5 criteria for depression with mixed features: a farewell to mixed depression. Acta Psychiatr Scand. 2014;129:4–16. PMID 23600771 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Kowatch RA, et al. Diagnosis, phenomenology, differential diagnosis, and comorbidity of pediatric bipolar disorder. J Clin Psychiatry. 2016;77 Suppl E1:e1. PMID 27570927 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Lazaratou H, et al. Attention-deficit hyperactivity disorder or bipolar disorder in childhood? Psychiatriki. 2012;23:304–313. PMID 23399752 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Miller CJ, et al. Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder. J Affect Disord. 2004;81:167–171. PMID 15306144 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Miller S, et al. The prevalence and diagnostic validity of short-duration hypomanic episodes and major depressive episodes. Curr Psychiatry Rep. 2016;18:27. PMID 26830885 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Na KS, et al. Prevalence of DSM-5 mixed features: a meta-analysis and systematic review. J Affect Disord. 2021;282:203–210. PMID 33418368 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Nierenberg AA, et al. Diagnosis and Treatment of Bipolar Disorder: A Review. JAMA. 2023;330:1370–1380. PMID 37815563 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md, epidemiology-and-course.md, overview.md
• Parker G, et al. Cyclothymia. Depress Anxiety. 2012;29:487–494. PMID 22553122 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Sharma V, et al. Screening for postpartum bipolar disorder: validation of the Mood Disorder Questionnaire. J Affect Disord. 2011;131:408–411. PMID 21185082 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• van de Burgt N, et al. Psychiatric manifestations of inborn errors of metabolism: a systematic review. Neurosci Biobehav Rev. 2023;144:104970. PMID 36436739 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Van Meter AR, et al. Cyclothymic disorder: a critical review. Clin Psychol Rev. 2012;32:229–243. PMID 22459786 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Verdolini N, et al. The state of the art of the DSM-5 “with mixed features” specifier. ScientificWorldJournal. 2015;2015:757258. PMID 26380368 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Vieta E, et al. Bipolar II disorder: arguments for and against a distinct diagnostic entity. Bipolar Disord. 2008;10:163–178. PMID 18199235 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Wang HR, et al. The influence of current mood states on screening accuracy of the Mood Disorder Questionnaire. Clin Psychopharmacol Neurosci. 2020;18:25–31. PMID 31958902 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Wang HR, et al. The validity of the Mood Disorder Questionnaire for screening bipolar disorder: a meta-analysis. Depress Anxiety. 2015;32:527–538. PMID 26010478 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Youngstrom EA, et al. Improving the global identification of bipolar spectrum disorders: meta-analysis of diagnostic accuracy of checklists. Psychol Bull. 2018;144:315–342. PMID 29389179 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md
• Zaratiegui RM, et al. Sensitivity and specificity of the Mood Disorder Questionnaire and the Bipolar Spectrum Diagnostic Scale in Argentinean patients with mood disorders. J Affect Disord. 2011;132:445–449. PMID 21440943 — tags: [bipolar-disorder, diagnosis_bipolar_spectrum] — cited by: diagnosis-and-bipolar-spectrum.md

Epidemiology and course

• Antunes A, et al. Disability and common mental disorders: Results from the World Mental Health Survey Initiative Portugal. Eur Psychiatry. 2018;49:56–61. PMID 29366849 — tags: [bipolar-disorder, epidemiology_course, statistics] — cited by: literature/statistics/STATISTICS.md
• Almeida OP, et al. Bipolar disorder: similarities and differences between patients with illness onset before and after 65 years. Int Psychogeriatr. 2002;14:311–322. PMID 12475092 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Altshuler LL, et al. Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively. Am J Psychiatry. 2010;167:708–715. PMID 20231325 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Baldessarini RJ, et al. Episode cycles with increasing recurrences in first-episode bipolar-I disorder patients. J Affect Disord. 2012;136:149–154. PMID 21943930 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Baryshnikov I, et al. Diagnostic conversion from unipolar depression: a 15-year register study. Bipolar Disord. 2020;22:582–592. PMID 32385906 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Bebbington P, et al. The epidemiology of bipolar affective disorder. Soc Psychiatry Psychiatr Epidemiol. 1995;30:279–292. PMID 8560330 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Biazus TB, et al. All-cause and cause-specific mortality among people with bipolar disorder: a systematic review and meta-analysis. Mol Psychiatry. 2023;28:2508-2524. PMID 37491460 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md, clinical-trials-landscape.md, patient-experience-and-advocacy.md, red-flags-and-safety-concerns.md, overview.md
• Birmaher B, et al. Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry. 2006;63:175–183. PMID 16461861 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Carpenter JS, et al. Predicting emergence of full-threshold bipolar and psychotic disorders in young people. Psychol Med. 2022;52:1990–2000. PMID 33121545 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Dominiak M, et al. The impact of bipolar spectrum disorders on professional functioning: a systematic review. Front Psychiatry. 2022;13:951008. PMID 36090375 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Esan O, et al. Epidemiology and burden of bipolar disorder in Africa: a systematic review. Soc Psychiatry Psychiatr Epidemiol. 2016;51:93–100. PMID 26155900 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• GBD 2019 Mental Disorders Collaborators. Global burden of 12 mental disorders, 1990–2019. Lancet Psychiatry. 2022;9:137–150. PMID 35026139 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md, overview.md
• Hu YH, et al. Predictors for early detection of conversion from major depression to bipolar disorder. JMIR Med Inform. 2020;8:e14278. PMID 32242821 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Jiang J, et al. Global, regional, and national burden of bipolar disorder, 1990–2021. J Affect Disord. 2025;389:119638. PMID 40499832 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Joffe RT, et al. A prospective, longitudinal study of percentage of time spent ill in bipolar I or II disorders. Bipolar Disord. 2004;6:62–66. PMID 14996142 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Goldberg JF, et al. Consistency of remission and outcome in bipolar and unipolar mood disorders: a 10-year prospective follow-up. J Affect Disord. 2004;81:123–131. PMID 15306137 — tags: [bipolar-disorder, epidemiology_course, statistics] — cited by: literature/statistics/STATISTICS.md
• Kohn R, et al. The treatment gap in mental health care. Bull World Health Organ. 2004;82:858–866. PMID 15640922 — tags: [bipolar-disorder, epidemiology_course, statistics] — cited by: literature/statistics/STATISTICS.md
• Kroon JS, et al. Incidence rates and risk factors of bipolar disorder in the general population. Bipolar Disord. 2013;15:306–313. PMID 23531096 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Lomastro MJ, et al. Manic morbidity and executive function impairment as determinants of long-term psychosocial dysfunction. Acta Psychiatr Scand. 2021;144:72–81. PMID 33792890 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Merikangas KR, et al. Prevalence and correlates of bipolar spectrum disorder in the World Mental Health Survey Initiative. Arch Gen Psychiatry. 2011;68:241–251. PMID 21383262 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md, comorbidity-and-differential-diagnosis.md, overview.md
• Mitchell PB, et al. Bipolar disorder in a national survey: impact of differing diagnostic algorithms. Acta Psychiatr Scand. 2013;127:381–393. PMID 22906117 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Montoya A, et al. Functioning and symptomatic outcomes in patients with bipolar I disorder in syndromal remission: a 1-year prospective cohort study. J Affect Disord. 2010;127:50–57. PMID 20557947 — tags: [bipolar-disorder, epidemiology_course, statistics] — cited by: literature/statistics/STATISTICS.md
• Oliveira JP, et al. Predictors of conversion from major depressive disorder to bipolar disorder. Psychiatry Res. 2021;297:113740. PMID 33493732 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Pallaskorpi S, et al. Predominant polarity in bipolar I and II disorders: a five-year follow-up study. J Affect Disord. 2019;246:806–813. PMID 30634112 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Rhee SJ, et al. Predictors of diagnostic conversion from major depression to bipolar disorder. Psychol Med. 2023;53:7805–7816. PMID 37427550 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Subramaniam M, et al. Prevalence, correlates, comorbidity and severity of bipolar disorder: Singapore Mental Health Study. J Affect Disord. 2013;146:189–196. PMID 23017543 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Teh WL, et al. Prevalence and correlates of bipolar spectrum disorders in Singapore. J Affect Disord. 2020;274:339–346. PMID 32469825 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md
• Tokumitsu K, et al. Real-world clinical predictors of manic/hypomanic episodes among outpatients. PLoS One. 2021;16:e0262129. PMID 34972188 — tags: [bipolar-disorder, epidemiology_course] — cited by: epidemiology-and-course.md

Genetics and neurobiology

• Agnew-Blais J, et al. Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder: a systematic review and meta-analysis. Lancet Psychiatry. 2016. PMID 26873185 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md, comorbidity-and-differential-diagnosis.md, suicide-mortality-and-physical-health.md
• Atagun MI, et al. Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder. Psychiatry Research: Neuroimaging. 2020. PMID 32361172 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Chen G, et al. Functional and structural brain differences in bipolar disorder: a multimodal meta-analysis of neuroimaging studies. Psychological Medicine. 2022. PMID 36093787 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Ching CRK, et al. What we learn about bipolar disorder from large-scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group. Human Brain Mapping. 2022. PMID 32725849 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. 2019. PMID 31835028 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Dargél AA, et al. C-reactive protein alterations in bipolar disorder: a meta-analysis. Journal of Clinical Psychiatry. 2015. PMID 25742201 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Fernandes BS, et al. Leptin in bipolar disorder: A systematic review and meta-analysis. Eur Psychiatry. 2016;35:1-7. PMID 27065008 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md, suicide-mortality-and-physical-health.md, biomarkers-and-digital-phenotyping.md
• Grigolon RB, et al. Hypersomnia and Bipolar Disorder: A systematic review and meta-analysis of proportion. Journal of Affective Disorders. 2019. PMID 30611064 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Li HJ, et al. Novel Risk Loci Associated With Genetic Risk for Bipolar Disorder Among Han Chinese Individuals: A Genome-Wide Association Study and Meta-analysis. JAMA Psychiatry. 2021. PMID 33263727 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Linke M, et al. Chronotype in individuals with schizophrenia: A meta-analysis. Schizophrenia Research. 2021. PMID 34332427 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Lizano P, et al. A Meta-analysis of Retinal Cytoarchitectural Abnormalities in Schizophrenia and Bipolar Disorder. Schizophr Bull. 2020;46:43-53. PMID 31112601 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md, biomarkers-and-digital-phenotyping.md
• McNamara RK, et al. Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. Bipolar Disorders. 2016. PMID 27087497 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Miola A, et al. Insulin resistance in bipolar disorder: A systematic review of illness course and clinical correlates. Journal of Affective Disorders. 2023. PMID 37086806 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md, suicide-mortality-and-physical-health.md
• Mullins N, et al. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics. 2021. PMID 34002096 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Pfeifer JC, et al. Meta-analysis of amygdala volumes in children and adolescents with bipolar disorder. Journal of the American Academy of Child & Adolescent Psychiatry. 2008. PMID 18827720 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Scott LJ, et al. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proceedings of the National Academy of Sciences USA. 2009. PMID 19416921 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Simjanoski M, et al. Lifestyle interventions for bipolar disorders: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews. 2023. PMID 37263531 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md
• Stahl EA, et al. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019;51:793-803. PMID 31043756 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md, comorbidity-and-differential-diagnosis.md, biomarkers-and-digital-phenotyping.md
• van Hulzen KJE, et al. Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis. Biological Psychiatry. 2017. PMID 27890468 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md, comorbidity-and-differential-diagnosis.md
• Wu Y, et al. Higher frequencies of CNV deletions in bipolar disorder among Chinese Population. Mol Psychiatry. 2026. PMID 42661060 — tags: [bipolar-disorder, genetics_neurobiology] — cited by: genetics-and-neurobiology.md, OPEN-QUESTIONS.md

Mania and mixed states

• Vázquez GH, et al. Mixed symptoms in major depressive and bipolar disorders: a systematic review. J Affect Disord. 2018;225:756–760. PMID 28922738 — tags: [bipolar-disorder, mania_mixed_states, statistics] — cited by: literature/statistics/STATISTICS.md
• Cipriani A, et al. Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet. 2011. PMID 21851976 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md
• Cipriani A, et al. Haloperidol alone or in combination for acute mania. Cochrane Database of Systematic Reviews. 2006. PMID 16856043 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md
• Sachs GS, et al. Cariprazine in the treatment of acute mania in bipolar I disorder: a double-blind, placebo-controlled, phase III trial. Journal of Affective Disorders. 2015. PMID 25532076 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md
• Fornaro M, et al. Atypical antipsychotics in the treatment of acute bipolar depression with mixed features: a systematic review and exploratory meta-analysis. International Journal of Molecular Sciences. 2016. PMID 26891297 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md
• Goldberg JF, et al. Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from STEP-BD. American Journal of Psychiatry. 2007. PMID 17728419 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md, antidepressant-controversy.md
• Takeshima M, et al. Treating mixed mania/hypomania: a review and synthesis of the evidence. CNS Spectrums. 2017. PMID 28004626 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md
• Kishi T, et al. Pharmacological treatment for bipolar mania: a systematic review and network meta-analysis of double-blind randomized controlled trials. Molecular Psychiatry. 2022. PMID 34642461 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md, overview.md
• Miura T, et al. Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: a systematic review and network meta-analysis. Lancet Psychiatry. 2014. PMID 26360999 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md, maintenance-and-relapse-prevention.md, lithium.md
• Xiao N, et al. The efficacy of pharmacological interventions in the treatment of major depressive disorder and bipolar depression with mixed features: a systematic review. Bipolar Disorders. 2025. PMID 40808264 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md, bipolar-depression.md, antidepressant-controversy.md
• Sachs GS, et al. Adjunctive treatment of acute mania: a clinical overview. Acta Psychiatrica Scandinavica Supplementum. 2007. PMID 17688460 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md
• Shim IH, et al. Pharmacological treatment of major depressive episodes with mixed features: a systematic review. Clinical Psychopharmacology and Neuroscience. 2018. PMID 30466209 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md
• Smith LA, et al. Pharmacological interventions for acute bipolar mania: a systematic review of randomized placebo-controlled trials. Bipolar Disorders. 2007. PMID 17845269 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md
• Khanna S, et al. Risperidone in the treatment of acute mania: double-blind, placebo-controlled study. British Journal of Psychiatry. 2005. PMID 16135859 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md
• Tohen M, et al. Olanzapine versus placebo in the treatment of acute mania. American Journal of Psychiatry. 1999. PMID 10327902 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md
• Miola A, et al. Prevalence and outcomes of rapid cycling bipolar disorder: mixed method systematic meta-review. Journal of Psychiatric Research. 2023. PMID 37429185 — tags: [bipolar-disorder, mania_mixed_states] — cited by: mania-and-mixed-states.md, antidepressant-controversy.md

Bipolar depression

• Yildiz A, et al. Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2023. PMID 37595997 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md, antidepressant-controversy.md, overview.md
• Bahji A, et al. Efficacy and safety of racemic ketamine and esketamine for depression: a systematic review and meta-analysis. Expert Opinion on Drug Safety. 2022. PMID 35231204 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md
• Calabrese JR, et al. Efficacy and safety of lumateperone for major depressive episodes associated with bipolar I or bipolar II disorder. American Journal of Psychiatry. 2021. PMID 34551584 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md
• Calabrese JR, et al. Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled trials. Bipolar Disorders. 2008. PMID 18271912 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md
• Citrome L. Olanzapine-fluoxetine combination for the treatment of bipolar depression. Expert Opinion on Pharmacotherapy. 2011. PMID 22035291 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md
• Earley W, et al. Cariprazine treatment of bipolar depression: a randomized double-blind placebo-controlled phase 3 study. American Journal of Psychiatry. 2019. PMID 30845817 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md, overview.md
• Frye MA, et al. A placebo-controlled evaluation of adjunctive modafinil in bipolar depression. American Journal of Psychiatry. 2007. PMID 17671288 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md
• Geddes JR, et al. Lamotrigine for treatment of bipolar depression: individual patient data from five randomised trials. British Journal of Psychiatry. 2009. PMID 19118318 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md
• Kato T, et al. Double-blind, placebo-controlled study of lurasidone monotherapy for the treatment of bipolar I depression. Psychiatry and Clinical Neurosciences. 2020. PMID 32827348 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md
• Loebel A, et al. Lurasidone monotherapy in the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study. American Journal of Psychiatry. 2014. PMID 24170180 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md, overview.md
• McElroy SL, et al. A double-blind, placebo-controlled study of quetiapine and paroxetine in bipolar depression (EMBOLDEN II). Journal of Clinical Psychiatry. 2010. PMID 20122366 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md, antidepressant-controversy.md
• Rajagopalan K, et al. Direct and indirect effects of lurasidone monotherapy on functional improvement among patients with bipolar depression. International Journal of Bipolar Disorders. 2016. PMID 26928122 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md
• Thase ME, et al. Efficacy of quetiapine monotherapy in bipolar I and II depression: the BOLDER II study. Journal of Clinical Psychopharmacology. 2006. PMID 17110817 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md, overview.md
• Tohen M, et al. Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression. Archives of General Psychiatry. 2003. PMID 14609883 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md, antidepressant-controversy.md, overview.md
• Kato M, et al. Efficacy and safety of lurasidone in bipolar I depression with and without rapid cycling. Journal of Affective Disorders. 2023. PMID 37245552 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md
• Lam RW, et al. Light therapy for patients with bipolar depression: systematic review and meta-analysis of randomized controlled trials. Canadian Journal of Psychiatry. 2020. PMID 31826657 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md, psychotherapy-and-self-management.md
• Young AH, et al. A double-blind, placebo-controlled study of quetiapine and lithium monotherapy in bipolar depression (EMBOLDEN I). Journal of Clinical Psychiatry. 2010. PMID 20122369 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md, lithium.md
• Zarate CA Jr, et al. Pramipexole for bipolar II depression: a placebo-controlled proof of concept study. Biological Psychiatry. 2004. PMID 15219473 — tags: [bipolar-disorder, bipolar_depression] — cited by: bipolar-depression.md

Maintenance and relapse prevention

• Bowden CL, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients. Archives of General Psychiatry. 2003. PMID 12695317 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md, lithium.md, overview.md
• Calabrese JR, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients. Journal of Clinical Psychiatry. 2003. PMID 14628976 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md, lithium.md
• Cipriani A, et al. Valproic acid, valproate and divalproex in maintenance treatment of bipolar disorder. Cochrane Database of Systematic Reviews. 2013. PMID 24132760 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md
• Colom F, et al. Group psychoeducation for stabilised bipolar disorders: 5-year outcome of a randomised clinical trial. British Journal of Psychiatry. 2009. PMID 19252157 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md, psychotherapy-and-self-management.md
• de Vries C, et al. Effectiveness of restarted lithium treatment after discontinuation. Bipolar Disorders. 2013. PMID 23911110 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md, lithium.md
• Geddes JR, et al. Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE). Lancet. 2010. PMID 20092882 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md, lithium.md
• Kishi T, et al. Mood stabilizers and/or antipsychotics for bipolar disorder in the maintenance phase: systematic review and network meta-analysis. Mol Psychiatry. 2021;26:4146-4157. PMID 33177610 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md, clinical-trials-landscape.md, red-flags-and-safety-concerns.md, overview.md
• Kishi T, et al. Recurrence of mania or depression among adult bipolar patients who continued using lithium. Journal of Clinical Psychopharmacology. 2020. PMID 32701902 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md, lithium.md
• Kishi T, et al. Recurrence rates in stable bipolar disorder patients after drug discontinuation versus drug maintenance: a systematic review and meta-analysis. Psychological Medicine. 2021. PMID 33046156 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md, lithium.md
• Lam DH, et al. Psychological therapies in bipolar disorder: effect of illness history on relapse prevention. Bipolar Disorders. 2009. PMID 19624386 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md, psychotherapy-and-self-management.md
• Lindström L, et al. Maintenance therapy with second generation antipsychotics for bipolar disorder: systematic review and meta-analysis. Journal of Affective Disorders. 2017. PMID 28222360 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md
• Miklowitz DJ, et al. A randomized study of family-focused psychoeducation and pharmacotherapy in outpatient management of bipolar disorder. Archives of General Psychiatry. 2003. PMID 12963672 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md, psychotherapy-and-self-management.md
• Oya K, et al. Efficacy and safety of lithium and lamotrigine for maintenance treatment: a systematic review and meta-analysis. Neuropsychopharmacology Reports. 2019. PMID 31026388 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md, lithium.md
• Vieta E, et al. Effectiveness of psychotropic medications in maintenance phase of bipolar disorder: meta-analysis. International Journal of Neuropsychopharmacology. 2011. PMID 21733231 — tags: [bipolar-disorder, maintenance_relapse_prevention] — cited by: maintenance-and-relapse-prevention.md

Lithium

• Cipriani A, et al. Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. BMJ. 2013;346:f3646. PMID 23814104 — tags: [bipolar-disorder, lithium] — cited by: lithium.md, clinical-trials-landscape.md, red-flags-and-safety-concerns.md, overview.md
• Keller MB, et al. Subsyndromal symptoms in bipolar disorder: comparison of standard and low serum levels of lithium. Archives of General Psychiatry. 1992. PMID 1586272 — tags: [bipolar-disorder, lithium] — cited by: lithium.md
• Hsu CW, et al. Lithium concentration and recurrence risk during maintenance treatment: multicenter cohort and meta-analysis. Acta Psychiatrica Scandinavica. 2021. PMID 34227095 — tags: [bipolar-disorder, lithium] — cited by: lithium.md
• McKnight RF, et al. Lithium toxicity profile: a systematic review and meta-analysis. Lancet. 2012;379:721-728. PMID 22265699 — tags: [bipolar-disorder, lithium] — cited by: lithium.md, clinical-trials-landscape.md, red-flags-and-safety-concerns.md
• Nabi Z, et al. Effects of lithium on suicide and suicidal behaviour: systematic review and meta-analysis of randomised trials. Epidemiology and Psychiatric Sciences. 2022. PMID 36111461 — tags: [bipolar-disorder, lithium] — cited by: lithium.md, overview.md
• Patorno E, et al. Lithium Use in Pregnancy and the Risk of Cardiac Malformations. New England Journal of Medicine. 2017. PMID 28591541 — tags: [bipolar-disorder, lithium] — cited by: lithium.md, pregnancy-and-reproductive-health.md
• Schoretsanitis G, et al. Prevalence of impaired kidney function in patients with long-term lithium treatment. Bipolar Disorders. 2022. PMID 34783413 — tags: [bipolar-disorder, lithium] — cited by: lithium.md

Antidepressant controversy

• Fornaro M, et al. Incidence, prevalence and clinical correlates of antidepressant-emergent mania in bipolar depression. Bipolar Disorders. 2018. PMID 29441650 — tags: [bipolar-disorder, antidepressant_controversy] — cited by: antidepressant-controversy.md
• Gijsman HJ, et al. Antidepressants for bipolar depression: a systematic review of randomized controlled trials. American Journal of Psychiatry. 2004. PMID 15337640 — tags: [bipolar-disorder, antidepressant_controversy] — cited by: antidepressant-controversy.md
• Leverich GS, et al. Risk of switch in mood polarity during trials of venlafaxine, sertraline and bupropion. American Journal of Psychiatry. 2006. PMID 16449476 — tags: [bipolar-disorder, antidepressant_controversy] — cited by: antidepressant-controversy.md
• Oliva V, et al. Switch to mania after acute antidepressant treatment for bipolar depression: systematic review and network meta-analysis. EClinicalMedicine. 2025. PMID 40823496 — tags: [bipolar-disorder, antidepressant_controversy] — cited by: antidepressant-controversy.md
• Post RM, et al. Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline. British Journal of Psychiatry. 2006. PMID 16880481 — tags: [bipolar-disorder, antidepressant_controversy] — cited by: antidepressant-controversy.md
• Sachs GS, et al. Effectiveness of adjunctive antidepressant treatment for bipolar depression. New England Journal of Medicine. 2007. PMID 17392295 — tags: [bipolar-disorder, antidepressant_controversy] — cited by: antidepressant-controversy.md, overview.md
• Sidor MM, Macqueen GM. Antidepressants for acute treatment of bipolar depression: systematic review and meta-analysis. Journal of Clinical Psychiatry. 2011. PMID 21034686 — tags: [bipolar-disorder, antidepressant_controversy] — cited by: antidepressant-controversy.md
• Taylor DM, et al. Comparative efficacy and acceptability of drug treatments for bipolar depression. Acta Psychiatrica Scandinavica. 2014. PMID 25283309 — tags: [bipolar-disorder, antidepressant_controversy] — cited by: antidepressant-controversy.md
• Zhang Y, et al. Antidepressants for bipolar disorder: a meta-analysis of randomized, double-blind, controlled trials. Neural Regeneration Research. 2013. PMID 25206617 — tags: [bipolar-disorder, antidepressant_controversy] — cited by: antidepressant-controversy.md

Psychotherapy and self-management

• Beynon S, et al. Psychosocial interventions for prevention of relapse in bipolar disorder. British Journal of Psychiatry. 2008. PMID 18174500 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Cardoso Tde A, et al. Biological rhythm and bipolar disorder: twelve-month follow-up of a randomized clinical trial. Journal of Nervous and Mental Disease. 2015. PMID 26348588 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Chiang KJ, et al. Efficacy of cognitive-behavioral therapy in patients with bipolar disorder: meta-analysis of randomized trials. PLoS One. 2017. PMID 28472082 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Colom F, et al. A randomized trial on the efficacy of group psychoeducation in prophylaxis of recurrences in bipolar patients. Archives of General Psychiatry. 2003. PMID 12695318 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Colom F, et al. Psychoeducation efficacy in bipolar disorders: beyond compliance enhancement. Journal of Clinical Psychiatry. 2003. PMID 14628987 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Depp CA, et al. Augmenting psychoeducation with a mobile intervention for bipolar disorder. Journal of Affective Disorders. 2015. PMID 25479050 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Goulding EH, et al. Effects of a smartphone-based self-management intervention for individuals with bipolar disorder. JAMA Psychiatry. 2023. PMID 36542401 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Hautzinger M, Meyer TD. Psychotherapy for bipolar disorder: systematic review of controlled studies. Nervenarzt. 2007. PMID 17604972 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Hlastala SA, et al. Interpersonal and social rhythm therapy for adolescents with bipolar disorder. Depression and Anxiety. 2010. PMID 20186968 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Gliddon E, et al. A randomized controlled trial of MoodSwings 2.0. Bipolar Disorders. 2019. PMID 29931798 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Miklowitz DJ, et al. Family-focused treatment for adolescents with bipolar disorder: results of a 2-year randomized trial. Archives of General Psychiatry. 2008. PMID 18762591 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Miklowitz DJ, et al. Intensive psychosocial intervention enhances functioning in patients with bipolar depression. American Journal of Psychiatry. 2007. PMID 17728418 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Barnes CW, et al. A web-based preventive intervention program for bipolar disorder. Journal of Affective Disorders. 2015. PMID 25554993 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Rea MM, et al. Family-focused treatment versus individual treatment for bipolar disorder. Journal of Consulting and Clinical Psychology. 2003. PMID 12795572 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Reinares M, et al. Impact of caregiver group psychoeducation on the course and outcome of bipolar patients in remission. Bipolar Disorders. 2008. PMID 18452447 — tags: [bipolar-disorder, psychotherapy_self_management] — cited by: psychotherapy-and-self-management.md
• Astill Wright L, et al. Mood Monitoring, Mood Tracking, and Ambulatory Assessment Interventions in Depression and Bipolar Disorder: Systematic Review and Meta-Analysis of Randomized Controlled Trials. JMIR Ment Health. 2026;13:e84020. PMID 41499681 — tags: [bipolar-disorder, psychotherapy_self_management, biomarkers_digital_phenotyping] — cited by: psychotherapy-and-self-management.md, biomarkers-and-digital-phenotyping.md, OPEN-QUESTIONS.md
• Faurholt-Jepsen M, et al. The effect of smartphone-based monitoring and treatment including clinical feedback in progressed bipolar disorder: the SmartBipolar trial randomised controlled parallel-group trial. Int J Bipolar Disord. 2026;14:17. PMID 41865316 — tags: [bipolar-disorder, psychotherapy_self_management, biomarkers_digital_phenotyping] — cited by: psychotherapy-and-self-management.md, biomarkers-and-digital-phenotyping.md, OPEN-QUESTIONS.md
• Yeom JW, et al. Circadian Rhythm Stabilization App to Prevent Mood Episode Recurrence in Patients With Mood Disorders. Am J Psychiatry. 2026. PMID 42337416 — tags: [bipolar-disorder, psychotherapy_self_management, biomarkers_digital_phenotyping] — cited by: psychotherapy-and-self-management.md, biomarkers-and-digital-phenotyping.md, OPEN-QUESTIONS.md

Comorbidity and differential diagnosis

• Asherson P, et al. Differential diagnosis, comorbidity, and treatment of attention-deficit/hyperactivity disorder in relation to bipolar disorder or borderline personality disorder in adults. Current Medical Research and Opinion. 2014. PMID 24804976 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Bartoli F, et al. Cannabis use disorder and suicide attempts in bipolar disorder: A meta-analysis. Neuroscience & Biobehavioral Reviews. 2019. PMID 31121199 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md, suicide-mortality-and-physical-health.md, red-flags-and-safety-concerns.md
• Bartoli F, et al. Clinical correlates of DSM-5 mixed features in bipolar disorder: A meta-analysis. Journal of Affective Disorders. 2020. PMID 32697704 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md, suicide-mortality-and-physical-health.md
• Bayes A, et al. Differential Diagnosis of Bipolar II Disorder and Borderline Personality Disorder. Current Psychiatry Reports. 2019. PMID 31749106 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Carvalho AF, et al. Screening for bipolar spectrum disorders: A comprehensive meta-analysis of accuracy studies. Journal of Affective Disorders. 2015. PMID 25451435 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Catalán A, et al. The proportion of people with primary affective disorders presenting to early intervention services: systematic review and meta-analysis. British Journal of Psychiatry. 2026. PMID 42057639 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Frías Á, et al. Comorbidity in pediatric bipolar disorder: prevalence, clinical impact, etiology and treatment. Journal of Affective Disorders. 2015. PMID 25545605 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Hartman CA, et al. Anxiety, mood, and substance use disorders in adult men and women with and without attention-deficit/hyperactivity disorder. Neuroscience & Biobehavioral Reviews. 2023. PMID 37149075 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Messer T, et al. Substance abuse in patients with bipolar disorder: A systematic review and meta-analysis. Psychiatry Research. 2017. PMID 28419959 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Massó Rodriguez A, et al. A systematic review of bipolar disorder and borderline personality disorder: overlap and discrimination of both diagnoses. Aust N Z J Psychiatry. 2021. PMID 34177664 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Bayes A, et al. Differentiation of bipolar disorder versus borderline personality disorder: A machine learning approach. J Affect Disord. 2021;288:68-73. PMID 33845326 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Parker G, et al. Why might bipolar disorder and borderline personality disorder be bonded? Journal of Psychiatric Research. 2022. PMID 35397334 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Phillips ML, Kupfer DJ. Bipolar disorder diagnosis: challenges and future directions. Lancet. 2013. PMID 23663952 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Radua J, et al. Meta-analysis of the effects of adjuvant drugs in co-occurring bipolar and substance use disorder. Spanish Journal of Psychiatry and Mental Health. 2024. PMID 37689524 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Sayyah M, et al. Assessment of the diagnostic performance of two new tools versus routine screening instruments for bipolar disorder: a meta-analysis. Revista Brasileira de Psiquiatria. 2022. PMID 35588536 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Schiweck C, et al. Comorbidity of ADHD and adult bipolar disorder: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews. 2021. PMID 33515607 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Wright L, et al. Differential diagnosis of borderline personality disorder and bipolar disorder: Self-concept, identity and self-esteem. Clinical Psychology & Psychotherapy. 2022. PMID 33811707 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md
• Yapıcı Eser H, et al. Anxiety disorders comorbidity in pediatric bipolar disorder: a meta-analysis and meta-regression study. Acta Psychiatrica Scandinavica. 2020. PMID 31899546 — tags: [bipolar-disorder, comorbidity_differential_diagnosis] — cited by: comorbidity-and-differential-diagnosis.md

Suicide, mortality and physical health

• Ayerbe L, et al. Hypertension risk and clinical care in patients with bipolar disorder or schizophrenia. Journal of Affective Disorders. 2018. PMID 28915505 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Chan JKN, et al. Life expectancy and years of potential life lost in bipolar disorder: systematic review and meta-analysis. British Journal of Psychiatry. 2022. PMID 35184778 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Chan JKN, et al. Mortality, Revascularization, and Cardioprotective Pharmacotherapy After Acute Coronary Syndrome in Patients With Severe Mental Illness. Schizophrenia Bulletin. 2022. PMID 35786737 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Cirone C, et al. What Do We Know about the Long-Term Course of Early Onset Bipolar Disorder? Brain Sciences. 2021. PMID 33800274 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Dong Q, Ye X. Risk of heart failure in patients with schizophrenia or bipolar disorder: A systematic review and meta-analysis. Pak J Med Sci. 2026;42:2129-2137. PMID 42668911 — tags: [bipolar-disorder, suicide_mortality_physical_health, statistics] — cited by: suicide-mortality-and-physical-health.md, literature/statistics/STATISTICS.md, OPEN-QUESTIONS.md
• Gustafsson TT, et al. Cause-specific mortality due to physical illness in severe mental disorders in Europe. Lancet Public Health. 2026. PMID 42480565 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Hayes JF, et al. A systematic review and meta-analysis of premature mortality in bipolar affective disorder. Acta Psychiatr Scand. 2015;131:417-425. PMID 25735195 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md, red-flags-and-safety-concerns.md
• Kambey PA, et al. The bi-directional association between bipolar disorder and obesity. International Journal of Obesity. 2023. PMID 36806758 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Khoso AB, et al. Prevalence of suicidal ideation and suicide attempts in individuals with psychosis and bipolar disorder in South Asia. BJPsych Open. 2023. PMID 37814419 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Lambert AM, et al. Temporal trends in associations between severe mental illness and risk of cardiovascular disease. PLoS Medicine. 2022. PMID 35439243 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Rotella F, et al. Long-term metabolic and cardiovascular effects of antipsychotic drugs. European Neuropsychopharmacology. 2020. PMID 31917068 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Salari N, et al. Global prevalence of metabolic syndrome among individuals with bipolar disorder. Archives of Psychiatric Nursing. 2025. PMID 40921519 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Solmi M, et al. Disparities in Screening and Treatment of Cardiovascular Diseases in Patients With Mental Disorders Across the World. American Journal of Psychiatry. 2021. PMID 34256605 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Tao H, et al. A Systematic Review and Meta-Analysis of Metabolic Syndrome Prevalence in Chinese Inpatients with Bipolar Disorder. Hormone and Metabolic Research. 2022. PMID 35738391 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Uelman C, et al. Examination of the intersection of bipolar I disorder status and cannabis use disorder severity in relation to health-related quality-of-life and lifetime suicide attempts. J Psychiatr Res. 2026;202:206-210. PMID 42664567 — tags: [bipolar-disorder, suicide_mortality_physical_health, statistics] — cited by: suicide-mortality-and-physical-health.md, literature/statistics/STATISTICS.md
• Walker ER, et al. Mortality in mental disorders and global disease burden implications. JAMA Psychiatry. 2015. PMID 25671328 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Wang JX, et al. The efficacy of lithium in the treatment of suicidal ideation, behavior and suicide. Journal of Affective Disorders. 2025. PMID 40441661 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Yuan M, et al. Bipolar disorder and the risk for stroke incidence and mortality: a meta-analysis. Neurological Sciences. 2022. PMID 34052937 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md
• Zhang L, et al. Reproductive and metabolic abnormalities in women taking valproate for bipolar disorder. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2016. PMID 27160812 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md, pregnancy-and-reproductive-health.md
• Zhao Z, et al. The potential association between obesity and bipolar disorder: A meta-analysis. Journal of Affective Disorders. 2016. PMID 27262632 — tags: [bipolar-disorder, suicide_mortality_physical_health] — cited by: suicide-mortality-and-physical-health.md

Pregnancy and reproductive health

• Bergink V, et al. Management of Bipolar Disorder in Pregnancy and Postpartum: A Clinicians' Guide. CNS Drugs. 2025. PMID 40593436 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Bjørk MH, et al. Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability. JAMA Neurology. 2022. PMID 35639399 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Bodén R, et al. Risks of adverse pregnancy and birth outcomes in women treated or not treated with mood stabilisers for bipolar disorder. BMJ. 2012. PMID 23137820 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Cantilino A, et al. Mood Stabilizers, Antipsychotics, and Electroconvulsive Therapy in Patients With Bipolar Disorder During Pregnancy and Postpartum. Journal of Psychiatric Practice. 2025. PMID 40679799 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Chan JKN, et al. Risk of adverse pregnancy, delivery and neonatal outcomes associated with bipolar disorder and prenatal use of mood stabilizers. Psychiatry Research. 2024. PMID 38914040 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Cohen JM, et al. Anticonvulsant Mood Stabilizer and Lithium Use and Risk of Adverse Pregnancy Outcomes. Journal of Clinical Psychiatry. 2019. PMID 31237992 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Fornaro M, et al. Lithium Exposure During Pregnancy and the Postpartum Period. American Journal of Psychiatry. 2020. PMID 31623458 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Gehrmann A, et al. Lithium Medication in Pregnancy and Breastfeeding—A Case Series. Medicina. 2021. PMID 34207460 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Imaz ML, et al. Peripartum lithium management: Early maternal and neonatal outcomes. Journal of Affective Disorders. 2024. PMID 39187196 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Kan ACO, et al. Psychotropic drug utilization patterns in pregnant women with bipolar disorder. European Neuropsychopharmacology. 2022. PMID 35151952 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Madley-Dowd P, et al. Antiseizure medication use during pregnancy and children's neurodevelopmental outcomes. Nature Communications. 2024. PMID 39548057 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Molenaar NM, et al. Management of lithium dosing around delivery: An observational study. Bipolar Disorders. 2021. PMID 32526071 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Newport DJ, et al. Lamotrigine in bipolar disorder: efficacy during pregnancy. Bipolar Disorders. 2008. PMID 18402631 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Pacchiarotti I, et al. Mood stabilizers and antipsychotics during breastfeeding: Focus on bipolar disorder. European Neuropsychopharmacology. 2016. PMID 27568278 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Samalin L, et al. Evolution and characteristics of the use of valproate in women of childbearing age with bipolar disorder. Journal of Affective Disorders. 2020. PMID 32745833 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Sharma V, et al. Occurrence of postpartum manic or mixed episodes in women with bipolar I disorder. Bipolar Disorders. 2024. PMID 38258551 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Tebeka S, et al. Clinical characteristics of bipolar disorders with postpartum depressive onset. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2021. PMID 33347983 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Viguera AC, et al. Risk of recurrence in women with bipolar disorder during pregnancy: prospective study of mood stabilizer discontinuation. American Journal of Psychiatry. 2007. PMID 18056236 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md
• Wesseloo R, et al. Risk of Postpartum Relapse in Bipolar Disorder and Postpartum Psychosis. American Journal of Psychiatry. 2016. PMID 26514657 — tags: [bipolar-disorder, pregnancy_reproductive_health] — cited by: pregnancy-and-reproductive-health.md

Guidelines

• Cutler AJ, et al. Anhedonia in patients with major depressive disorder (MDD): State-of-the-art consensus review. Psychiatry Res. 2026;364:117225. PMID 42314447 — tags: [guidelines, screened-not-bipolar] — cited by: literature/guidelines/REGISTRY.md (search provenance only: screened in the 2026-08-31 guideline sweep and excluded as MDD-specific, not a bipolar practice guideline)
• Sakurai H, et al. Pharmacological management of bipolar disorder: Japanese expert consensus. Bipolar Disord. 2020;22:822–830. PMID 32558145 — tags: [bipolar-disorder, guidelines, Japan] — cited by: literature/guidelines/REGISTRY.md
• American College of Obstetricians and Gynecologists. Treatment and Management of Mental Health Conditions During Pregnancy and Postpartum: Clinical Practice Guideline No. 5. Obstet Gynecol. 2023;141:1262-1288. PMID 37486661 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md, red-flags-and-safety-concerns.md
• Arnold MJ. Management of Bipolar Disorder: Guidelines From the VA/DoD. Am Fam Physician. 2024;109:585-587. PMID 38905567 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Cheng CM, et al. Taiwan consensus on biological treatment of bipolar disorder: the 2022 update. Asian J Psychiatr. 2023;82:103480. PMID 36724568 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Fountoulakis KN, et al. CINP Treatment Guidelines for Bipolar Disorder in Adults, Part 1: Background and Methods. Int J Neuropsychopharmacol. 2017;20:98-120. PMID 27815414 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Fountoulakis KN, et al. CINP Treatment Guidelines for Bipolar Disorder in Adults, Part 2: Review, Grading of Evidence, and Algorithm. Int J Neuropsychopharmacol. 2017;20:121-179. PMID 27816941 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Fountoulakis KN, et al. CINP Treatment Guidelines for Bipolar Disorder in Adults, Part 3: Clinical Guidelines. Int J Neuropsychopharmacol. 2017;20:180-195. PMID 27941079 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Garriga M, et al. Assessment and management of agitation in psychiatry: Expert consensus. World J Biol Psychiatry. 2016;17:86-128. PMID 26912127 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md, red-flags-and-safety-concerns.md
• Gautam S, et al. Clinical Practice Guidelines for Bipolar Affective Disorder in Children and Adolescents. Indian J Psychiatry. 2019;61:S294-S305. PMID 30745704 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Giese AA, et al. Closing the gap between guidelines for bipolar disorder treatment and clinical practice. Am J Psychiatry. 2009;166:1205-1206. PMID 19884231 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Goodwin GM, et al. Evidence-based guidelines for treating bipolar disorder: Revised third edition recommendations from the British Association for Psychopharmacology. J Psychopharmacol. 2016;30:495-553. PMID 26979387 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Grunze H, et al. WFSBP Guidelines: acute and long-term treatment of mixed states in bipolar disorder. World J Biol Psychiatry. 2018;19:2-58. PMID 29098925 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md, red-flags-and-safety-concerns.md
• Grunze H, et al. WFSBP guidelines: update 2012 on long-term treatment of bipolar disorder. World J Biol Psychiatry. 2013;14:154-219. PMID 23480132 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Jon DI, et al. Korean Medication Algorithm Project for Bipolar Disorder: changes over 16 years and five editions. Bipolar Disord. 2020;22:461-471. PMID 32202033 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Kato T, et al. Practice Guidelines for Bipolar Disorder by the Japanese Society of Mood Disorders. Psychiatry Clin Neurosci. 2024;78:633-645. PMID 39194164 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Keramatian K, et al. The CANMAT and ISBD Guidelines for the Treatment of Bipolar Disorder: Summary and a 2023 Update of Evidence. Focus. 2023;21:344-353. PMID 38695002 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md, overview.md
• Kowatch RA, et al. Treatment guidelines for children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2005;44:213-235. PMID 15725966 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Malhi GS, et al. RANZCP clinical practice guidelines for mood disorders: bipolar disorder summary. Med J Aust. 2018;208:219-225. PMID 29540132 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Malhi GS, et al. The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders. Aust N Z J Psychiatry. 2021;55:7-117. PMID 33353391 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Ostacher MJ, et al. Synopsis of the 2023 US Department of Veterans Affairs and US Department of Defense Clinical Practice Guideline for the Management of Bipolar Disorder. J Clin Psychiatry. 2025;86:24cs15546. PMID 39832345 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Park JH, et al. Global perspectives on bipolar disorder treatment: comparative analysis of international guidelines. BJPsych Open. 2024;10:e75. PMID 38586960 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Parker GB, et al. Is there consensus across international evidence-based guidelines for the management of bipolar disorder? Acta Psychiatr Scand. 2017;135:515-526. PMID 28260229 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Sarris J, et al. WFSBP and CANMAT clinician guidelines for psychiatric disorders with nutraceuticals and phytoceuticals. World J Biol Psychiatry. 2022;23:424-455. PMID 35311615 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Shah N, et al. Clinical Practice Guidelines for Management of Bipolar Disorder. Indian J Psychiatry. 2017;59:S51-S66. PMID 28216785 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Menon V, et al. Clinical practice guidelines for the management of bipolar disorder: 2025 update. Indian J Psychiatry. 2026;68:8-43. PMID 41694044 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md, literature/guidelines/REGISTRY.md
• Wang Z, et al. Assessment and management of bipolar disorder: Principal summary of updated Chinese guidelines. Bipolar Disord. 2018;20:289-292. PMID 29604156 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md
• Yatham LN, et al. Canadian Network for Mood and Anxiety Treatments and International Society for Bipolar Disorders 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disord. 2018;20:97-170. PMID 29536616 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md, red-flags-and-safety-concerns.md
• Yatham LN. The evolution of CANMAT Bipolar Disorder Guidelines: past, present, and future. Bipolar Disord. 2013;15:58-60. PMID 23339676 — tags: [bipolar-disorder, guidelines] — cited by: guidelines.md

Biomarkers and digital phenotyping

• Antosik-Wójcińska AZ, et al. Smartphone as a monitoring tool for bipolar disorder: a systematic review. Int J Med Inform. 2020;138:104131. PMID 32305023 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Astill Wright L, et al. Recommendations for Research and Clinical Implementation of Ambulatory Assessment, Mood Monitoring, Digital Phenotyping, and Remote Measurement Technology in Mood Disorders: Synthesis of Systematic Review Findings. JMIR Ment Health. 2026;13:e79501. PMID 42228842 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md, OPEN-QUESTIONS.md
• Busk J, et al. Forecasting Mood in Bipolar Disorder From Smartphone Self-assessments. JMIR Mhealth Uhealth. 2020;8:e15028. PMID 32234702 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md, clinical-trials-landscape.md
• Capuzzi E, et al. Malondialdehyde as a candidate biomarker for bipolar disorder: A meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2022;113:110469. PMID 34740710 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• da Rosa MI, et al. Serum S100B in manic bipolar disorder patients: Systematic review and meta-analysis. J Affect Disord. 2016;206:210-215. PMID 27475892 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• de Deus M, et al. Retinal electrophysiology in mood disorders: Toward clinically relevant biomarkers. A systematic review and meta-analysis. J Affect Disord. 2026. PMID 42669383 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• De Crescenzo F, et al. Actigraphic features of bipolar disorder: A systematic review and meta-analysis. Sleep Med Rev. 2017;33:58-69. PMID 28185811 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Dombi ZB, et al. Brain Derived Neurotrophic Factor and Cognitive Dysfunction in the Schizophrenia-Bipolar Spectrum: A Systematic Review and Meta-Analysis. Front Psychiatry. 2022;13:827322. PMID 35686181 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Faurholt-Jepsen M. Electronic monitoring in bipolar disorder. Dan Med J. 2018;65:B5460. PMID 29510813 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md, patient-experience-and-advocacy.md, red-flags-and-safety-concerns.md
• Fraccaro P, et al. Digital biomarkers from geolocation data in bipolar disorder and schizophrenia: a systematic review. J Am Med Inform Assoc. 2019;26:1412-1420. PMID 31260049 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Fries GR, et al. The miRNome of bipolar disorder. J Affect Disord. 2018;233:110-116. PMID 28969861 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Gama CS, et al. Staging and neuroprogression in bipolar disorder: a systematic review. Rev Bras Psiquiatr. 2013;35:70-74. PMID 23567604 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Hsieh YC, et al. Serum folate levels in bipolar disorder: a systematic review and meta-analysis. BMC Psychiatry. 2019;19:305. PMID 31640634 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Hu X, et al. Biomarkers and detection methods of bipolar disorder. Biosens Bioelectron. 2023;220:114842. PMID 36347076 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md, clinical-trials-landscape.md
• Langholm C, et al. Classifying and clustering mood disorder patients using smartphone data. NPJ Digit Med. 2023;6:238. PMID 38129571 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md, clinical-trials-landscape.md
• Long X, et al. Gray matter alterations in adolescent major depressive disorder and adolescent bipolar disorder. J Affect Disord. 2023;325:550-563. PMID 36669567 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Maatoug R, et al. Digital phenotype of mood disorders: A conceptual and critical review. Front Psychiatry. 2022;13:895860. PMID 35958638 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• MacDonald K, et al. Biomarkers for major depressive and bipolar disorders using metabolomics: A systematic review. Am J Med Genet B. 2019;180:122-137. PMID 30411484 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Obi-Azuike C, et al. A systematic review on gut-brain axis aberrations in bipolar disorder. Brain Behav. 2023;13:e3037. PMID 37127945 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Ortiz A, et al. Apps and gaps in bipolar disorder: electronic monitoring for episode prediction. J Affect Disord. 2021;295:1190-1200. PMID 34706433 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md, clinical-trials-landscape.md
• Roda Â, et al. Biomarkers and staging of bipolar disorder: a systematic review. Trends Psychiatry Psychother. 2015;37:3-11. PMID 25860561 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Ruiz-Sastre P, et al. Pharmacotherapeutic value of inflammatory and neurotrophic biomarkers in bipolar disorder: A systematic review. Prog Neuropsychopharmacol Biol Psychiatry. 2024;134:111056. PMID 38879067 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Saccaro LF, et al. Portable technologies for digital phenotyping of bipolar disorder: A systematic review. J Affect Disord. 2021;295:323-338. PMID 34488086 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md, clinical-trials-landscape.md, patient-experience-and-advocacy.md
• Tatham I, et al. Process and Outcome Evaluations of Smartphone Apps for Bipolar Disorder: Scoping Review. J Med Internet Res. 2022;24:e29114. PMID 35319470 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Tazawa Y, et al. Actigraphy for evaluation of mood disorders: A systematic review and meta-analysis. J Affect Disord. 2019;253:257-269. PMID 31060012 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md, clinical-trials-landscape.md
• Wada M, et al. The P300 event-related potential in bipolar disorder: A systematic review and meta-analysis. J Affect Disord. 2019;256:234-249. PMID 31200163 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md
• Zhong R, et al. Using Digital Phenotyping to Discriminate Unipolar Depression and Bipolar Disorder: Systematic Review. J Med Internet Res. 2025;27:e72229. PMID 40408762 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md, patient-experience-and-advocacy.md, overview.md
• Zhu Z, et al. Cortical thickness abnormalities in patients with bipolar disorder: A systematic review and meta-analysis. J Affect Disord. 2022;300:209-218. PMID 34971699 — tags: [bipolar-disorder, biomarkers_digital_phenotyping] — cited by: biomarkers-and-digital-phenotyping.md

Clinical trials

• Katz IR, et al. Lithium Treatment in the Prevention of Repeat Suicide-Related Outcomes in Veterans With Major Depression or Bipolar Disorder. JAMA Psychiatry. 2022;79:24-32. PMID 34787653 — tags: [bipolar-disorder, clinical_trials_landscape] — cited by: clinical-trials-landscape.md, red-flags-and-safety-concerns.md
• Paljärvi T, et al. Cardiovascular mortality in bipolar disorder: Population-based cohort study. Acta Psychiatr Scand. 2024;150:56-64. PMID 38826056 — tags: [bipolar-disorder, clinical_trials_landscape] — cited by: clinical-trials-landscape.md, red-flags-and-safety-concerns.md
• Roosen L, et al. Evidence-based treatment strategies for rapid cycling bipolar disorder: a systematic review. J Affect Disord. 2022;311:69-77. PMID 35545157 — tags: [bipolar-disorder, clinical_trials_landscape] — cited by: clinical-trials-landscape.md

Patient experience and advocacy

• Bulteau S, et al. Bipolar disorder and adherence: implications of manic subjective experience on treatment disruption. Patient Prefer Adherence. 2018;12:1355-1361. PMID 30100712 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md
• Cerimele JM, et al. Bipolar Disorder Symptom Monitoring Measures: A Mixed-Methods Study of Patient Preferences. J Acad Consult Liaison Psychiatry. 2024;65:148-156. PMID 37967752 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md
• Ellison N, et al. Bipolar disorder and stigma: a systematic review of the literature. J Affect Disord. 2013;151:805-820. PMID 24135506 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md
• Glossop Z, et al. Personal Recovery With Bipolar Disorder: A Network Analysis. Clin Psychol Psychother. 2024;31:e70001. PMID 39441546 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md
• Karidi MV, et al. Bipolar disorder and self-stigma: A comparison with schizophrenia. J Affect Disord. 2015;184:209-215. PMID 26112330 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md
• Krogh HB, et al. Bipolar disorder and sexuality: a preliminary qualitative pilot study. Int J Bipolar Disord. 2023;11:5. PMID 36735118 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md
• Miklowitz DJ, et al. Adjunctive Psychotherapy for Bipolar Disorder: A Systematic Review and Component Network Meta-analysis. JAMA Psychiatry. 2021;78:141-150. PMID 33052390 — tags: [bipolar-disorder, patient_experience_advocacy, psychotherapy_self_management] — cited by: patient-experience-and-advocacy.md, psychotherapy-and-self-management.md, overview.md
• Rabelo JL, et al. Psychoeducation in bipolar disorder: A systematic review. World J Psychiatry. 2021;11:1407-1424. PMID 35070785 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md
• Samalin L, et al. Shared Decision-Making: a Systematic Review Focusing on Mood Disorders. Curr Psychiatry Rep. 2018;20:23. PMID 29589129 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md
• Speirs B, et al. The lived experience of caring for someone with bipolar disorder: A qualitative study. PLoS One. 2023;18:e0280059. PMID 36656805 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md, red-flags-and-safety-concerns.md
• Williams E, et al. Burden and Heart Rate Variability in Bipolar Disorder Family Caregivers. West J Nurs Res. 2022;44:279-287. PMID 34889140 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md
• Wittkowski A, et al. Exploring psychosis and bipolar disorder in women: a critical review of the qualitative literature. BMC Psychiatry. 2014;14:281. PMID 25403956 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md
• Zhou Y, et al. Comparison of burden among family members of patients with schizophrenia and bipolar disorder in China. BMC Psychiatry. 2016;16:283. PMID 27515535 — tags: [bipolar-disorder, patient_experience_advocacy] — cited by: patient-experience-and-advocacy.md

Red flags and safety concerns

• Correll CU, et al. Cardiovascular disease in severe mental illness: large-scale meta-analysis. World Psychiatry. 2017;16:163-180. PMID 28498599 — tags: [bipolar-disorder, red_flags_safety_concerns] — cited by: red-flags-and-safety-concerns.md
• Decker BS, et al. Extracorporeal Treatment for Lithium Poisoning: EXTRIP recommendations. Clin J Am Soc Nephrol. 2015;10:875-887. PMID 25583292 — tags: [bipolar-disorder, red_flags_safety_concerns] — cited by: red-flags-and-safety-concerns.md
• García-Jiménez J, et al. Cigarette smoking and risk of suicide in bipolar disorder: a systematic review. Front Psychiatry. 2023;14:1179733. PMID 37275988 — tags: [bipolar-disorder, red_flags_safety_concerns] — cited by: red-flags-and-safety-concerns.md
• Goldberg JF, Truman CJ. Antidepressant-induced mania: an overview of current controversies. Bipolar Disord. 2003;5:407-420. PMID 14636364 — tags: [bipolar-disorder, red_flags_safety_concerns] — cited by: red-flags-and-safety-concerns.md
• Izadi N, et al. Suicide Assessment and Prevention in Bipolar Disorder. Focus. 2023;21:380-388. PMID 38695007 — tags: [bipolar-disorder, red_flags_safety_concerns] — cited by: red-flags-and-safety-concerns.md
• Lavonas EJ, Buchanan J. Hemodialysis for lithium poisoning. Cochrane Database Syst Rev. 2015;2015:CD007951. PMID 26374731 — tags: [bipolar-disorder, red_flags_safety_concerns] — cited by: red-flags-and-safety-concerns.md
• Miller JN, et al. Bipolar Disorder and Suicide: a Review. Curr Psychiatry Rep. 2020;22:6. PMID 31955273 — tags: [bipolar-disorder, red_flags_safety_concerns] — cited by: red-flags-and-safety-concerns.md
• Plans L, et al. Association between completed suicide and bipolar disorder: A systematic review. J Affect Disord. 2019;242:111-122. PMID 30173059 — tags: [bipolar-disorder, red_flags_safety_concerns] — cited by: red-flags-and-safety-concerns.md
• Schaffer A, et al. ISBD Task Force on Suicide: meta-analyses and meta-regression. Bipolar Disord. 2015;17:1-16. PMID 25329791 — tags: [bipolar-disorder, red_flags_safety_concerns] — cited by: red-flags-and-safety-concerns.md
• Sun M, et al. Lithium Toxicity in Older Adults: a Systematic Review of Case Reports. Clin Drug Investig. 2018;38:201-209. PMID 29189921 — tags: [bipolar-disorder, red_flags_safety_concerns] — cited by: red-flags-and-safety-concerns.md
• Zeller SL, et al. Managing Agitation Associated with Schizophrenia and Bipolar Disorder in the Emergency Setting. West J Emerg Med. 2016;17:165-172. PMID 26973742 — tags: [bipolar-disorder, red_flags_safety_concerns] — cited by: red-flags-and-safety-concerns.md

Overview and general reviews

• Cegla-Schvartzman FB, et al. Diagnostic stability in bipolar disorder. Harv Rev Psychiatry. 2019. PMID 30358663 — tags: [bipolar-disorder, overview] — cited by: overview.md
• Chancel R, et al. Biomarkers of bipolar disorder in late life. Curr Psychiatry Rep. 2024. PMID 38470559 — tags: [bipolar-disorder, overview] — cited by: overview.md
• Chen J, et al. Metabolomic biomarkers of bipolar disorder. J Affect Disord. 2024. PMID 38218254 — tags: [bipolar-disorder, overview] — cited by: overview.md
• El-Mallakh RS, et al. Antidepressants worsen rapid-cycling course in bipolar depression. J Affect Disord. 2015. PMID 26142612 — tags: [bipolar-disorder, overview] — cited by: overview.md
• Gordovez FJA, et al. The genetics of bipolar disorder. Mol Psychiatry. 2020. PMID 31907381 — tags: [bipolar-disorder, overview] — cited by: overview.md
• Harrison PJ, et al. The emerging neurobiology of bipolar disorder. Trends Neurosci. 2018. PMID 29169634 — tags: [bipolar-disorder, overview] — cited by: overview.md
• Hashimoto Y, et al. Lamotrigine in maintenance treatment of bipolar disorder. Cochrane Database Syst Rev. 2021. PMID 34523118 — tags: [bipolar-disorder, overview] — cited by: overview.md

Evidence broadening pass — 2026-09-03

• Frank E, et al. Interpersonal and social rhythm therapy: managing the chaos of bipolar disorder. Biological psychiatry. 2000;48:593-604. PMID 11018230 — tags: [bipolar-disorder, evidence-broadening-2026-09-03] — cited by: psychotherapy-and-self-management.md
• Dean BB, et al. A systematic review evaluating health-related quality of life, work impairment, and healthcare costs and utilization in bipolar disorder. Current medical research and opinion. 2004;20:139-54. PMID 15006007 — tags: [bipolar-disorder, evidence-broadening-2026-09-03] — cited by: overview.md
• Pavuluri MN, et al. Psychotic symptoms in pediatric bipolar disorder. Journal of affective disorders. 2004;80:19-28. PMID 15094254 — tags: [bipolar-disorder, evidence-broadening-2026-09-03] — cited by: diagnosis-and-bipolar-spectrum.md, literature/statistics/STATISTICS.md
• Yatham LN, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: update 2007. Bipolar disorders. 2006;8:721-39. PMID 17156158 — tags: [bipolar-disorder, evidence-broadening-2026-09-03] — cited by: guidelines.md, literature/guidelines/REGISTRY.md
• Youngstrom EA, et al. Pediatric bipolar disorder: validity, phenomenology, and recommendations for diagnosis. Bipolar disorders. 2008;10:194-214. PMID 18199237 — tags: [bipolar-disorder, evidence-broadening-2026-09-03] — cited by: diagnosis-and-bipolar-spectrum.md
• Amsterdam JD, et al. Venlafaxine versus lithium monotherapy of rapid and non-rapid cycling patients with bipolar II major depressive episode: a randomized, parallel group, open-label trial. Journal of affective disorders. 2009;112:219-30. PMID 18486235 — tags: [bipolar-disorder, evidence-broadening-2026-09-03] — cited by: antidepressant-controversy.md
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• Pedersen CB, et al. Absolute and relative risks of mental disorders in families: a Danish register-based study. The lancet. Psychiatry. 2025;12:590-599. PMID 40675715 — tags: [bipolar-disorder, evidence-broadening-2026-09-03] — cited by: epidemiology-and-course.md
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Screened contextual records retained for provenance

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