Effect of intensive versus standard blood pressure control on probable dementia¶

One-paragraph summary¶

SPRINT MIND compared intensive and standard systolic BP targets. Intensive control did not significantly reduce probable dementia (HR 0.83, 95% CI 0.67–1.04) but reduced MCI (HR 0.81, 95% CI 0.69–0.95); early trial termination reduced dementia-endpoint power (Williamson 2019, PMID 30688979).

Key findings¶

Dementia direction favored intensive control but crossed the null.
MCI was significantly reduced.
Endpoint hierarchy and power constrain interpretation.

Limitations¶

Selected trial population limits generalization.
Not a trial of established vascular dementia.
Cognitive subtype attribution was limited.

Why it matters¶

It is the best-known randomized anchor for the gap between vascular prevention and dementia-specific proof.

Cited by wiki pages¶

Prevention
Overview