Rheumatoid arthritis — master bibliography

Last curated: 2026-08-31 · 262 live-retrieved PubMed records cited across 18 wiki pages and literature artifacts.

The five 2026-08-31 additions were returned by live PubMed E-utilities searches in this sweep; earlier records retain their dated audit provenance. Grouping reflects the first principal topic; cross-page use is recorded explicitly.

Foundations

• Wang H, et al. Rheumatoid arthritis burden in 129 low- and middle-income countries from 1990 to 2023. iScience. 2026;29:116881. PMID 42495527 — tags: [rheumatoid-arthritis, epidemiology, burden, LMIC] — cited by: OPEN-QUESTIONS.md, STATISTICS.md

• Lipsky PE, et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med. 2000;343:1594-602. PMID 11096166 — tags: [rheumatoid-arthritis, overview] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, classification-and-diagnosis.md, epidemiology-and-burden.md, jak-inhibitors-and-targeted-therapy.md, overview.md, patient-experience-and-advocacy.md, synovial-immunobiology.md

• Rech J, et al. Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): a randomised, international, multicentre, double-blind, placebo-controlled trial. Lancet. 2024;403:850-859. PMID 38364841 — tags: [rheumatoid-arthritis, overview] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, clinical-trials-landscape.md, epidemiology-and-burden.md, genetics-environment-and-mucosal-origins.md, jak-inhibitors-and-targeted-therapy.md, overview.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md
• Cope AP, et al. Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial. Lancet. 2024;403:838-849. PMID 38364839 — tags: [rheumatoid-arthritis, overview] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, clinical-trials-landscape.md, epidemiology-and-burden.md, genetics-environment-and-mucosal-origins.md, jak-inhibitors-and-targeted-therapy.md, overview.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md
• Rubbert-Roth A, et al. Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis. N Engl J Med. 2020;383:1511-1521. PMID 33053283 — tags: [rheumatoid-arthritis, overview] — cited by: biologic-dmards.md, classification-and-diagnosis.md, epidemiology-and-burden.md, jak-inhibitors-and-targeted-therapy.md, overview.md, patient-experience-and-advocacy.md
• Ytterberg SR, et al. Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis. N Engl J Med. 2022;386:316-326. PMID 35081280 — tags: [rheumatoid-arthritis, overview] — cited by: biologic-dmards.md, classification-and-diagnosis.md, conventional-dmards.md, epidemiology-and-burden.md, extra-articular-and-comorbid-disease.md, guidelines.md, jak-inhibitors-and-targeted-therapy.md, overview.md, patient-experience-and-advocacy.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md, treat-to-target-and-remission.md
• Smolen JS, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update. Ann Rheum Dis. 2023;82:3-18. PMID 36357155 — tags: [rheumatoid-arthritis, overview] — cited by: biologic-dmards.md, classification-and-diagnosis.md, conventional-dmards.md, epidemiology-and-burden.md, guidelines.md, jak-inhibitors-and-targeted-therapy.md, overview.md, patient-experience-and-advocacy.md, treat-to-target-and-remission.md
• Fraenkel L, et al. 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Rheumatol. 2021;73:1108-1123. PMID 34101376 — tags: [rheumatoid-arthritis, overview] — cited by: biologic-dmards.md, classification-and-diagnosis.md, conventional-dmards.md, difficult-to-treat-and-refractory-ra.md, epidemiology-and-burden.md, guidelines.md, jak-inhibitors-and-targeted-therapy.md, overview.md, patient-experience-and-advocacy.md, treat-to-target-and-remission.md
• Jang S, et al. Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells. Int J Mol Sci. 2022;23:905. PMID 35055087 — tags: [rheumatoid-arthritis, overview] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, classification-and-diagnosis.md, epidemiology-and-burden.md, jak-inhibitors-and-targeted-therapy.md, overview.md, patient-experience-and-advocacy.md, synovial-immunobiology.md
• Humby F, et al. Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial. Lancet. 2021;397:305-317. PMID 33485455 — tags: [rheumatoid-arthritis, overview] — cited by: biomarkers-and-tissue-precision.md, classification-and-diagnosis.md, clinical-trials-landscape.md, difficult-to-treat-and-refractory-ra.md, epidemiology-and-burden.md, genetics-environment-and-mucosal-origins.md, overview.md, patient-experience-and-advocacy.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md
• van Heemst J, et al. HLA and rheumatoid arthritis: how do they connect?. Ann Med. 2014;46:304-10. PMID 24813459 — tags: [rheumatoid-arthritis, overview] — cited by: biomarkers-and-tissue-precision.md, classification-and-diagnosis.md, clinical-trials-landscape.md, difficult-to-treat-and-refractory-ra.md, genetics-environment-and-mucosal-origins.md, overview.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md
• Perera J, et al. Clinical Phenotypes, Serological Biomarkers, and Synovial Features Defining Seropositive and Seronegative Rheumatoid Arthritis: A Literature Review. Cells. 2024;13:743. PMID 38727279 — tags: [rheumatoid-arthritis, overview] — cited by: biomarkers-and-tissue-precision.md, classification-and-diagnosis.md, clinical-trials-landscape.md, difficult-to-treat-and-refractory-ra.md, genetics-environment-and-mucosal-origins.md, overview.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md
• de Pablo P, et al. Systematic review of imaging tests to predict the development of rheumatoid arthritis in people with unclassified arthritis. Semin Arthritis Rheum. 2022;52:151919. PMID 34782180 — tags: [rheumatoid-arthritis, overview] — cited by: biomarkers-and-tissue-precision.md, classification-and-diagnosis.md, clinical-trials-landscape.md, difficult-to-treat-and-refractory-ra.md, genetics-environment-and-mucosal-origins.md, overview.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md
• Mandl P, et al. The role of ultrasound and magnetic resonance imaging for treat to target in rheumatoid arthritis and psoriatic arthritis. Rheumatology (Oxford). 2019;58:2091-2098. PMID 31518423 — tags: [rheumatoid-arthritis, overview] — cited by: biomarkers-and-tissue-precision.md, classification-and-diagnosis.md, clinical-trials-landscape.md, conventional-dmards.md, difficult-to-treat-and-refractory-ra.md, epidemiology-and-burden.md, genetics-environment-and-mucosal-origins.md, guidelines.md, overview.md, patient-experience-and-advocacy.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md, treat-to-target-and-remission.md
• Aletaha D, et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62:2569-81. PMID 20872595 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, epidemiology-and-burden.md, overview.md, patient-experience-and-advocacy.md
• Varache S, et al. Diagnostic accuracy of ACR/EULAR 2010 criteria for rheumatoid arthritis in a 2-year cohort. J Rheumatol. 2011;38:1250-7. PMID 21572146 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, epidemiology-and-burden.md, overview.md, patient-experience-and-advocacy.md
• Kay J, et al. ACR/EULAR 2010 rheumatoid arthritis classification criteria. Rheumatology (Oxford). 2012;51 Suppl 6:vi5-9. PMID 23221588 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, overview.md
• Breedveld FC, et al. Appropriate and effective management of rheumatoid arthritis. Ann Rheum Dis. 2004;63:627-33. PMID 15140767 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, overview.md
• Smolen JS, et al. Rheumatoid arthritis. Lancet. 2016;388:2023-2038. PMID 27156434 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, epidemiology-and-burden.md, overview.md, patient-experience-and-advocacy.md
• GBD 2021 Rheumatoid Arthritis Collaborators Global, regional, and national burden of rheumatoid arthritis, 1990-2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5:e594-e610. PMID 37795020 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, epidemiology-and-burden.md, extra-articular-and-comorbid-disease.md, overview.md, patient-experience-and-advocacy.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Dedmon LE, et al. The genetics of rheumatoid arthritis. Rheumatology (Oxford). 2020;59:2661-2670. PMID 32638005 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, clinical-trials-landscape.md, epidemiology-and-burden.md, genetics-environment-and-mucosal-origins.md, overview.md, patient-experience-and-advocacy.md, preclinical-autoimmunity-and-prevention.md
• Grigor C, et al. Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial. Lancet. 2004;364:263-9. PMID 15262104 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, clinical-trials-landscape.md, conventional-dmards.md, difficult-to-treat-and-refractory-ra.md, epidemiology-and-burden.md, genetics-environment-and-mucosal-origins.md, guidelines.md, overview.md, patient-experience-and-advocacy.md, preclinical-autoimmunity-and-prevention.md, treat-to-target-and-remission.md
• Korpela M, et al. Retardation of joint damage in patients with early rheumatoid arthritis by initial aggressive treatment with disease-modifying antirheumatic drugs: five-year experience from the FIN-RACo study. Arthritis Rheum. 2004;50:2072-81. PMID 15248204 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, clinical-trials-landscape.md, conventional-dmards.md, difficult-to-treat-and-refractory-ra.md, epidemiology-and-burden.md, genetics-environment-and-mucosal-origins.md, guidelines.md, overview.md, patient-experience-and-advocacy.md, preclinical-autoimmunity-and-prevention.md, treat-to-target-and-remission.md
• Kerschbaumer A, et al. Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2023;82:95-106. PMID 36368906 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, conventional-dmards.md, epidemiology-and-burden.md, guidelines.md, overview.md, patient-experience-and-advocacy.md, treat-to-target-and-remission.md
• Studenic P, et al. American College of Rheumatology/EULAR Remission Criteria for Rheumatoid Arthritis: 2022 Revision. Arthritis Rheumatol. 2023;75:15-22. PMID 36274193 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, conventional-dmards.md, epidemiology-and-burden.md, guidelines.md, overview.md, patient-experience-and-advocacy.md, treat-to-target-and-remission.md
• Wang W, et al. Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review. Eur J Med Chem. 2018;158:502-516. PMID 30243154 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, conventional-dmards.md, epidemiology-and-burden.md, guidelines.md, overview.md, patient-experience-and-advocacy.md, treat-to-target-and-remission.md
• Nagy G, et al. EULAR definition of difficult-to-treat rheumatoid arthritis. Ann Rheum Dis. 2021;80:31-35. PMID 33004335 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, conventional-dmards.md, difficult-to-treat-and-refractory-ra.md, epidemiology-and-burden.md, guidelines.md, overview.md, patient-experience-and-advocacy.md, treat-to-target-and-remission.md
• Kadura S, et al. Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management. Eur Respir Rev. 2021;30:210011. PMID 34168062 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, clinical-trials-landscape.md, epidemiology-and-burden.md, extra-articular-and-comorbid-disease.md, genetics-environment-and-mucosal-origins.md, overview.md, patient-experience-and-advocacy.md, preclinical-autoimmunity-and-prevention.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Lee YH, et al. All-cause and cause-specific mortality in rheumatoid arthritis: a meta-analysis. Z Rheumatol. 2024;83:314-320. PMID 38918258 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, epidemiology-and-burden.md, extra-articular-and-comorbid-disease.md, overview.md, patient-experience-and-advocacy.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• van Tuyl LH, et al. Patient-Reported Outcomes in Rheumatoid Arthritis. Rheum Dis Clin North Am. 2016;42:219-37. PMID 27133486 — tags: [rheumatoid-arthritis, overview] — cited by: classification-and-diagnosis.md, difficult-to-treat-and-refractory-ra.md, epidemiology-and-burden.md, overview.md, patient-experience-and-advocacy.md
• Frazzei G, et al. Prevention of rheumatoid arthritis: A systematic literature review of preventive strategies in at-risk individuals. Autoimmun Rev. 2023;22:103217. PMID 36280095 — tags: [rheumatoid-arthritis, overview] — cited by: clinical-trials-landscape.md, epidemiology-and-burden.md, genetics-environment-and-mucosal-origins.md, overview.md, preclinical-autoimmunity-and-prevention.md
• Nagy G, et al. EULAR points to consider for the management of difficult-to-treat rheumatoid arthritis. Ann Rheum Dis. 2022;81:20-33. PMID 34407926 — tags: [rheumatoid-arthritis, classification-and-diagnosis] — cited by: classification-and-diagnosis.md, conventional-dmards.md, difficult-to-treat-and-refractory-ra.md, guidelines.md, treat-to-target-and-remission.md
• Buch MH, et al. Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis. Nat Rev Rheumatol. 2021;17:17-33. PMID 33293696 — tags: [rheumatoid-arthritis, classification-and-diagnosis] — cited by: classification-and-diagnosis.md, conventional-dmards.md, difficult-to-treat-and-refractory-ra.md, guidelines.md, treat-to-target-and-remission.md
• Greenblatt HK, et al. Preclinical rheumatoid arthritis and rheumatoid arthritis prevention. Curr Opin Rheumatol. 2020;32:289-296. PMID 32205569 — tags: [rheumatoid-arthritis, classification-and-diagnosis] — cited by: classification-and-diagnosis.md, clinical-trials-landscape.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md
• Lucchino B, et al. Mucosa-Environment Interactions in the Pathogenesis of Rheumatoid Arthritis. Cells. 2019;8:700. PMID 31295951 — tags: [rheumatoid-arthritis, epidemiology-and-burden] — cited by: clinical-trials-landscape.md, epidemiology-and-burden.md, genetics-environment-and-mucosal-origins.md, patient-experience-and-advocacy.md, preclinical-autoimmunity-and-prevention.md
• Michaud K, et al. Systematic Literature Review of Residual Symptoms and an Unmet Need in Patients With Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2021;73:1606-1616. PMID 32619340 — tags: [rheumatoid-arthritis, epidemiology-and-burden] — cited by: conventional-dmards.md, difficult-to-treat-and-refractory-ra.md, epidemiology-and-burden.md, guidelines.md, patient-experience-and-advocacy.md, treat-to-target-and-remission.md
• Pope JE, et al. Management of Fatigue in Rheumatoid Arthritis. RMD Open. 2020;6:e001084. PMID 32385141 — tags: [rheumatoid-arthritis, epidemiology-and-burden] — cited by: difficult-to-treat-and-refractory-ra.md, epidemiology-and-burden.md, patient-experience-and-advocacy.md
• Safiri S, et al. Global, regional and national burden of rheumatoid arthritis 1990-2017: a systematic analysis of the Global Burden of Disease study 2017. Ann Rheum Dis. 2019;78:1463-1471. PMID 31511227 — tags: [rheumatoid-arthritis, epidemiology-and-burden] — cited by: epidemiology-and-burden.md, extra-articular-and-comorbid-disease.md, patient-experience-and-advocacy.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Druce KL, et al. Predictors of fatigue in rheumatoid arthritis. Rheumatology (Oxford). 2019;58:v29-v34. PMID 31435677 — tags: [rheumatoid-arthritis, epidemiology-and-burden] — cited by: epidemiology-and-burden.md, patient-experience-and-advocacy.md
• Cassone G, et al. Treatment of Rheumatoid Arthritis-Associated Interstitial Lung Disease: Lights and Shadows. J Clin Med. 2020;9:1082. PMID 32290218 — tags: [rheumatoid-arthritis, epidemiology-and-burden] — cited by: epidemiology-and-burden.md, extra-articular-and-comorbid-disease.md, patient-experience-and-advocacy.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md

Origins and prevention

• Rivellese F, et al. Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial. Nat Med. 2022;28:1256-1268. PMID 35589854 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, clinical-trials-landscape.md, conventional-dmards.md, difficult-to-treat-and-refractory-ra.md, genetics-environment-and-mucosal-origins.md, guidelines.md, jak-inhibitors-and-targeted-therapy.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md, treat-to-target-and-remission.md
• Schonfeldova B, et al. Synovial single-cell heterogeneity, zonation and interactions: a patchwork of effectors in arthritis. Rheumatology (Oxford). 2022;61:913-925. PMID 34559213 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, difficult-to-treat-and-refractory-ra.md, genetics-environment-and-mucosal-origins.md, jak-inhibitors-and-targeted-therapy.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md
• Bhamidipati K, et al. Precision medicine in rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2022;36:101742. PMID 35248489 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: biomarkers-and-tissue-precision.md, clinical-trials-landscape.md, difficult-to-treat-and-refractory-ra.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md
• Atzeni F, et al. Biomarkers in Rheumatoid Arthritis. Isr Med Assoc J. 2017;19:512-516. PMID 28825772 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: biomarkers-and-tissue-precision.md, clinical-trials-landscape.md, difficult-to-treat-and-refractory-ra.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md
• He S, et al. A longitudinal cohort study uncovers plasma protein biomarkers predating clinical onset and treatment response of rheumatoid arthritis. Nat Commun. 2025;16:6692. PMID 40691443 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: biomarkers-and-tissue-precision.md, clinical-trials-landscape.md, difficult-to-treat-and-refractory-ra.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md
• Ling SF, et al. Pharmacogenetics of methotrexate response in rheumatoid arthritis: an update. Pharmacogenomics. 2020;21:3-6. PMID 31849277 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: biomarkers-and-tissue-precision.md, conventional-dmards.md, difficult-to-treat-and-refractory-ra.md, genetics-environment-and-mucosal-origins.md, guidelines.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md, treat-to-target-and-remission.md
• Caproli A, et al. Calprotectin as a biomarker in rheumatoid arthritis: the potential predictive value of response to treatment. Bioanalysis. 2023;15:1111-1113. PMID 37584369 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: biomarkers-and-tissue-precision.md, difficult-to-treat-and-refractory-ra.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md, synovial-immunobiology.md
• Krijbolder DI, et al. Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial. Lancet. 2022;400:283-294. PMID 35871815 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md
• Cope AP, et al. Long-term outcomes of abatacept in individuals at risk of developing rheumatoid arthritis (ALTO): a randomised, double-blind, placebo-controlled trial. Lancet Rheumatol. 2026;8:e171-e180. PMID 41576971 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, overview.md, preclinical-autoimmunity-and-prevention.md, OPEN-QUESTIONS.md, STATISTICS.md
• Mulligen EV, et al. Long-term durability of a time-limited methotrexate intervention in patients with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative arthralgia at increased risk for rheumatoid arthritis (TREAT EARLIER): 5-year data from a double-blind, randomised, placebo-controlled trial. Lancet Rheumatol. 2026;8:e638-e649. PMID 42392130 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, overview.md, preclinical-autoimmunity-and-prevention.md, OPEN-QUESTIONS.md, STATISTICS.md
• Deane KD, et al. A Phase 2 Trial of Hydroxychloroquine in Individuals at Risk for Rheumatoid Arthritis. Arthritis Rheumatol. 2026;78:809-820. PMID 40884017 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, preclinical-autoimmunity-and-prevention.md, STATISTICS.md
• Petrovská N, et al. The pre-clinical phase of rheumatoid arthritis: From risk factors to prevention of arthritis. Autoimmun Rev. 2021;20:102797. PMID 33746022 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md
• Haville S, et al. Pre-RA: Can early diagnosis lead to prevention?. Best Pract Res Clin Rheumatol. 2022;36:101737. PMID 34991984 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md
• Dumoulin QA, et al. Development of rheumatoid arthritis after methotrexate in anticitrullinated protein antibody-negative people with clinically suspect arthralgia at risk of rheumatoid arthritis: 4-year data from the TREAT EARLIER trial. Lancet Rheumatol. 2024;6:e827-e836. PMID 39303731 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md
• Möller B, et al. Infectious Triggers in Periodontitis and the Gut in Rheumatoid Arthritis (RA): A Complex Story About Association and Causality. Front Immunol. 2020;11:1108. PMID 32582191 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md
• Kim Y, et al. Etiology and Pathogenesis of Rheumatoid Arthritis-Interstitial Lung Disease. Int J Mol Sci. 2023;24:14509. PMID 37833957 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, extra-articular-and-comorbid-disease.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Qi XY, et al. Gut microbiota in rheumatoid arthritis: Mechanistic insights, clinical biomarkers, and translational perspectives. Autoimmun Rev. 2025;24:103912. PMID 40825448 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md
• Frade-Sosa B, et al. Neutrophils, neutrophil extracellular traps, and rheumatoid arthritis: An updated review for clinicians. Reumatol Clin (Engl Ed). 2023;19:515-526. PMID 37867028 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md
• Aletaha D, et al. Precision medicine and management of rheumatoid arthritis. J Autoimmun. 2020;110:102405. PMID 32276742 — tags: [rheumatoid-arthritis, preclinical-autoimmunity-and-prevention] — cited by: clinical-trials-landscape.md, genetics-environment-and-mucosal-origins.md, preclinical-autoimmunity-and-prevention.md

Synovial biology and biomarkers

• Dalix E, et al. DNA hypo-methylation of the TNFA gene predicts response to methotrexate in rheumatoid arthritis but not in psoriatic arthritis. Rheumatology (Oxford). 2026. PMID 42664067 — tags: [rheumatoid-arthritis, biomarker, methotrexate, epigenetics] — cited by: OPEN-QUESTIONS.md, STATISTICS.md

• Breedveld FC, et al. The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum. 2006;54:26-37. PMID 16385520 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md

• Klareskog L, et al. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet. 2004;363:675-81. PMID 15001324 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md
• Gabay C, et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet. 2013;381:1541-50. PMID 23515142 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md
• Jones G, et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann Rheum Dis. 2010;69:88-96. PMID 19297346 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md
• Cohen SB, et al. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum. 2006;54:2793-806. PMID 16947627 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md
• Fleischmann R, et al. Efficacy of Abatacept and Adalimumab in Patients with Early Rheumatoid Arthritis With Multiple Poor Prognostic Factors: Post Hoc Analysis of a Randomized Controlled Clinical Trial (AMPLE). Rheumatol Ther. 2019;6:559-571. PMID 31642045 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md
• Lee YH, et al. Comparative efficacy and safety of tocilizumab, rituximab, abatacept and tofacitinib in patients with active rheumatoid arthritis that inadequately responds to tumor necrosis factor inhibitors: a Bayesian network meta-analysis of randomized controlled trials. Int J Rheum Dis. 2016;19:1103-1111. PMID 26692536 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md
• Sung YK, et al. Comparative efficacy and safety of biologic agents in patients with active rheumatoid arthritis and inadequate response to tumor necrosis factor inhibitors: A Bayesian network meta-analysis of randomized controlled trials. Int J Clin Pharmacol Ther. 2022;60:13-23. PMID 34622767 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md
• Cheng L, et al. New Insights From Single-Cell Sequencing Data: Synovial Fibroblasts and Synovial Macrophages in Rheumatoid Arthritis. Front Immunol. 2021;12:709178. PMID 34349767 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md
• Knab K, et al. Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation. Front Med (Lausanne). 2022;9:862161. PMID 35547214 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md
• Kemble S, et al. Critical Role of Synovial Tissue-Resident Macrophage and Fibroblast Subsets in the Persistence of Joint Inflammation. Front Immunol. 2021;12:715894. PMID 34539648 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md
• Pap T, et al. Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis. Arthritis Res. 2000;2:361-7. PMID 11094449 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biologic-dmards.md, biomarkers-and-tissue-precision.md, jak-inhibitors-and-targeted-therapy.md, synovial-immunobiology.md
• Komatsu N, et al. Mechanisms of joint destruction in rheumatoid arthritis - immune cell-fibroblast-bone interactions. Nat Rev Rheumatol. 2022;18:415-429. PMID 35705856 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biomarkers-and-tissue-precision.md, synovial-immunobiology.md
• Matsuda K, et al. New Insights into the Role of Synovial Fibroblasts Leading to Joint Destruction in Rheumatoid Arthritis. Int J Mol Sci. 2023;24:5173. PMID 36982247 — tags: [rheumatoid-arthritis, synovial-immunobiology] — cited by: biomarkers-and-tissue-precision.md, synovial-immunobiology.md

Treatment strategy and conventional therapy

• Fernández-Codina A, et al. Use of parenteral compared with oral glucocorticoids in early rheumatoid arthritis for chance of being off steroids and escalation of therapy at 1 year. Ann Rheum Dis. 2026. PMID 42665531 — tags: [rheumatoid-arthritis, glucocorticoids, early-ra] — cited by: OPEN-QUESTIONS.md, STATISTICS.md

• Konzett V, et al. Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2025 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2026;85:1039-1054. PMID 41997804 — tags: [rheumatoid-arthritis, guidelines] — cited by: guidelines.md, REGISTRY.md

• Laskou F, et al. Safety of synthetic and biological DMARDs: a systematic literature review informing the 2025 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis. 2026;85:1055-1072. PMID 41951459 — tags: [rheumatoid-arthritis, guidelines] — cited by: REGISTRY.md
• Yamaoka K, et al. 2024 Update of the Asia-Pacific League of Associations for Rheumatology (APLAR) Recommendations for Rheumatoid Arthritis Management. Int J Rheum Dis. 2026;29:e70752. PMID 42362943 — tags: [rheumatoid-arthritis, guidelines] — cited by: guidelines.md, REGISTRY.md
• Alberti ML, et al. Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD): An Official 2025 ALAT Clinical Practice Guideline. Arch Bronconeumol. 2026. PMID 42034552 — tags: [rheumatoid-arthritis, guidelines] — cited by: guidelines.md, REGISTRY.md

• Scott IC, et al. The 2026 British Society for Rheumatology guideline for pain management in people with inflammatory arthritis. Rheumatology (Oxford). 2026;65. PMID 42476581 — tags: [rheumatoid-arthritis, guidelines, pain] — cited by: REGISTRY.md

• van Vollenhoven RF, et al. Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial. Lancet. 2009;374:459-66. PMID 19665644 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: clinical-trials-landscape.md, conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md

• Tascilar K, et al. Treatment tapering and stopping in patients with rheumatoid arthritis in stable remission (RETRO): a multicentre, randomised, controlled, open-label, phase 3 trial. Lancet Rheumatol. 2021;3:e767-e777. PMID 38297524 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: clinical-trials-landscape.md, conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• van Mulligen E, et al. Tapering towards DMARD-free remission in established rheumatoid arthritis: 2-year results of the TARA trial. Ann Rheum Dis. 2020;79:1174-1181. PMID 32482645 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: clinical-trials-landscape.md, conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• Hazlewood GS, et al. Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic drugs for rheumatoid arthritis: abridged Cochrane systematic review and network meta-analysis. BMJ. 2016;353:i1777. PMID 27102806 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• Katchamart W, et al. Efficacy and toxicity of methotrexate (MTX) monotherapy versus MTX combination therapy with non-biological disease-modifying antirheumatic drugs in rheumatoid arthritis: a systematic review and meta-analysis. Ann Rheum Dis. 2009;68:1105-12. PMID 19054823 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• Bijlsma JW, et al. Glucocorticoids in the treatment of rheumatoid arthritis. Clin Exp Rheumatol. 2015;33:S34-6. PMID 26457916 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• Messelink MA, et al. What is the best target in a treat-to-target strategy in rheumatoid arthritis? Results from a systematic review and meta-regression analysis. RMD Open. 2023;9:e003196. PMID 37116986 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• Haschka J, et al. Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: interim results from the prospective randomised controlled RETRO study. Ann Rheum Dis. 2016;75:45-51. PMID 25660991 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• England BR, et al. 2022 American College of Rheumatology Guideline for Exercise, Rehabilitation, Diet, and Additional Integrative Interventions for Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2023;75:1603-1615. PMID 37227116 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• Peter WF, et al. Clinical Practice Guideline for Physical Therapist Management of People With Rheumatoid Arthritis. Phys Ther. 2021;101:pzab127. PMID 34003240 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• Saavedra AA, et al. Treatment of rheumatoid arthritis-associated interstitial lung disease: An appraisal of the 2023 ACR/CHEST guideline. Curr Treatm Opt Rheumatol. 2024;10:43-60. PMID 39822854 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, extra-articular-and-comorbid-disease.md, guidelines.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md, treat-to-target-and-remission.md
• Fautrel B, et al. 2024 update of the recommendations of the French Society of Rheumatology for the diagnosis and management of patients with rheumatoid arthritis. Joint Bone Spine. 2024;91:105790. PMID 39389412 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• Abud-Mendoza C, et al. Update of the guidelines for the pharmacological treatment of rheumatoid arthritis by the Mexican College of Rheumatology 2023. Reumatol Clin (Engl Ed). 2024;20:263-280. PMID 38796394 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• Harigai M, et al. 2024 Update of the Japan College of Rheumatology Clinical Practice Guidelines for the Management of Rheumatoid Arthritis: Secondary publication. Mod Rheumatol. 2025;35:387-401. PMID 39820350 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md
• Conley B, et al. What are the core recommendations for rheumatoid arthritis care? Systematic review of clinical practice guidelines. Clin Rheumatol. 2023;42:2267-2278. PMID 37291382 — tags: [rheumatoid-arthritis, treat-to-target-and-remission] — cited by: conventional-dmards.md, guidelines.md, treat-to-target-and-remission.md

Biologic and targeted therapy

• Ikeda K, et al. Real-World Outcomes of Baricitinib in Patients with Rheumatoid Arthritis: A Two-Year Observational Study of Overall and Difficult-to-Treat Patients in Japan. Mod Rheumatol. 2026. PMID 42667647 — tags: [rheumatoid-arthritis, baricitinib, difficult-to-treat, real-world] — cited by: STATISTICS.md

• Strand V, et al. Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials. Arthritis Res Ther. 2015;17:362. PMID 26669566 — tags: [rheumatoid-arthritis, biologic-dmards] — cited by: biologic-dmards.md, jak-inhibitors-and-targeted-therapy.md

• Tarp S, et al. Risk of serious adverse effects of biological and targeted drugs in patients with rheumatoid arthritis: a systematic review meta-analysis. Rheumatology (Oxford). 2017;56:417-425. PMID 28013201 — tags: [rheumatoid-arthritis, biologic-dmards] — cited by: biologic-dmards.md, jak-inhibitors-and-targeted-therapy.md
• Fleischmann R, et al. Upadacitinib Versus Placebo or Adalimumab in Patients With Rheumatoid Arthritis and an Inadequate Response to Methotrexate: Results of a Phase III, Double-Blind, Randomized Controlled Trial. Arthritis Rheumatol. 2019;71:1788-1800. PMID 31287230 — tags: [rheumatoid-arthritis, biologic-dmards] — cited by: biologic-dmards.md, jak-inhibitors-and-targeted-therapy.md
• Fleischmann R, et al. Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial. Lancet. 2017;390:457-468. PMID 28629665 — tags: [rheumatoid-arthritis, biologic-dmards] — cited by: biologic-dmards.md, jak-inhibitors-and-targeted-therapy.md
• Russell MD, et al. JAK inhibitors and the risk of malignancy: a meta-analysis across disease indications. Ann Rheum Dis. 2023;82:1059-1067. PMID 37247942 — tags: [rheumatoid-arthritis, biologic-dmards] — cited by: biologic-dmards.md, jak-inhibitors-and-targeted-therapy.md
• Kubo S, et al. JAK inhibitors for rheumatoid arthritis. Expert Opin Investig Drugs. 2023;32:333-344. PMID 37014106 — tags: [rheumatoid-arthritis, biologic-dmards] — cited by: biologic-dmards.md, jak-inhibitors-and-targeted-therapy.md
• Traves PG, et al. JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib. Ann Rheum Dis. 2021;80:865-875. PMID 33741556 — tags: [rheumatoid-arthritis, biologic-dmards] — cited by: biologic-dmards.md, jak-inhibitors-and-targeted-therapy.md
• Narváez J, et al. Janus kinase inhibitors in rheumatoid arthritis-associated interstitial lung disease: A systematic review and meta-analysis. Autoimmun Rev. 2024;23:103636. PMID 39270812 — tags: [rheumatoid-arthritis, biologic-dmards] — cited by: biologic-dmards.md, extra-articular-and-comorbid-disease.md, jak-inhibitors-and-targeted-therapy.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Hofman ZLM, et al. Difficult-to-treat rheumatoid arthritis: what have we learned and what do we still need to learn?. Rheumatology (Oxford). 2025;64:65-73. PMID 39383505 — tags: [rheumatoid-arthritis, difficult-to-treat-and-refractory-ra] — cited by: difficult-to-treat-and-refractory-ra.md
• David P, et al. Poly-Refractory Rheumatoid Arthritis: An Uncommon Subset of Difficult to Treat Disease With Distinct Inflammatory and Noninflammatory Phenotypes. Arthritis Rheumatol. 2024;76:510-521. PMID 38059326 — tags: [rheumatoid-arthritis, difficult-to-treat-and-refractory-ra] — cited by: difficult-to-treat-and-refractory-ra.md
• Su QY, et al. Efficacy and safety of current therapies for difficult-to-treat rheumatoid arthritis: a systematic review and network meta-analysis. J Transl Med. 2024;22:795. PMID 39198829 — tags: [rheumatoid-arthritis, difficult-to-treat-and-refractory-ra] — cited by: difficult-to-treat-and-refractory-ra.md
• Genovese MC, et al. Safety and efficacy of upadacitinib in patients with active rheumatoid arthritis refractory to biologic disease-modifying anti-rheumatic drugs (SELECT-BEYOND): a double-blind, randomised controlled phase 3 trial. Lancet. 2018;391:2513-2524. PMID 29908670 — tags: [rheumatoid-arthritis, difficult-to-treat-and-refractory-ra] — cited by: difficult-to-treat-and-refractory-ra.md
• Sung YK, et al. Comparative effectiveness and safety of non-tumour necrosis factor biologics and Janus kinase inhibitors in patients with active rheumatoid arthritis showing insufficient response to tumour necrosis factor inhibitors: A Bayesian network meta-analysis of randomized controlled trials. J Clin Pharm Ther. 2021;46:984-992. PMID 33600008 — tags: [rheumatoid-arthritis, difficult-to-treat-and-refractory-ra] — cited by: difficult-to-treat-and-refractory-ra.md
• Santos EJF, et al. Effectiveness of non-pharmacological and non-surgical interventions for rheumatoid arthritis: an umbrella review. JBI Database System Rev Implement Rep. 2019;17:1494-1531. PMID 31169776 — tags: [rheumatoid-arthritis, difficult-to-treat-and-refractory-ra] — cited by: difficult-to-treat-and-refractory-ra.md
• Bucci L, et al. Bispecific T cell engager therapy for refractory rheumatoid arthritis. Nat Med. 2024;30:1593-1601. PMID 38671240 — tags: [rheumatoid-arthritis, difficult-to-treat-and-refractory-ra] — cited by: difficult-to-treat-and-refractory-ra.md
• Katz P, et al. Fatigue in Rheumatoid Arthritis. Curr Rheumatol Rep. 2017;19:25. PMID 28386762 — tags: [rheumatoid-arthritis, difficult-to-treat-and-refractory-ra] — cited by: difficult-to-treat-and-refractory-ra.md, patient-experience-and-advocacy.md
• Michaud K, et al. Relative Impact of Pain and Fatigue on Work Productivity in Patients with Rheumatoid Arthritis from the RA-BEAM Baricitinib Trial. Rheumatol Ther. 2019;6:409-419. PMID 31228100 — tags: [rheumatoid-arthritis, difficult-to-treat-and-refractory-ra] — cited by: difficult-to-treat-and-refractory-ra.md, patient-experience-and-advocacy.md

Systemic disease and safety

• Sugiyama M, et al. Inflammatory and traditional risk factors associated with the progression of chronic kidney disease in patients with rheumatoid arthritis. Clin Exp Nephrol. 2026. PMID 42667508 — tags: [rheumatoid-arthritis, chronic-kidney-disease, comorbidity] — cited by: STATISTICS.md

• Restivo V, et al. Systematic review and meta-analysis of cardiovascular risk in rheumatological disease: Symptomatic and non-symptomatic events in rheumatoid arthritis and systemic lupus erythematosus. Autoimmun Rev. 2022;21:102925. PMID 34454117 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md

• Singh S, et al. Comparative Risk of Cardiovascular Events With Biologic and Synthetic Disease-Modifying Antirheumatic Drugs in Patients With Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Arthritis Care Res (Hoboken). 2020;72:561-576. PMID 30875456 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Mehta B, et al. Serious infection risk in rheumatoid arthritis compared with non-inflammatory rheumatic and musculoskeletal diseases: a US national cohort study. RMD Open. 2019;5:e000935. PMID 31245055 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• George MD, et al. Risk for Serious Infection With Low-Dose Glucocorticoids in Patients With Rheumatoid Arthritis : A Cohort Study. Ann Intern Med. 2020;173:870-878. PMID 32956604 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Xue AL, et al. Bone fracture risk in patients with rheumatoid arthritis: A meta-analysis. Medicine (Baltimore). 2017;96:e6983. PMID 28885321 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Jin S, et al. Incidence of fractures among patients with rheumatoid arthritis: a systematic review and meta-analysis. Osteoporos Int. 2018;29:1263-1275. PMID 29546507 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Kanis JA, et al. Rheumatoid arthritis and subsequent fracture risk: an individual person meta-analysis to update FRAX. Osteoporos Int. 2025;36:653-671. PMID 39955689 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Turk MA, et al. Ocular Manifestations in Rheumatoid Arthritis, Connective Tissue Disease, and Vasculitis: A Systematic Review and Metaanalysis. J Rheumatol. 2021;48:25-34. PMID 32358156 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Mertz P, et al. Rheumatoid vasculitis in 2023: Changes and challenges since the biologics era. Autoimmun Rev. 2023;22:103391. PMID 37468085 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• de Cerqueira DPA, et al. Biological therapy in rheumatoid vasculitis: a systematic review. Clin Rheumatol. 2021;40:1717-1724. PMID 33058033 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Murray KE, et al. Updated pharmacological management of rheumatoid arthritis for women before, during, and after pregnancy, reflecting recent guidelines. Ir J Med Sci. 2019;188:169-172. PMID 29748892 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Chin A, et al. Recommendations for the Use of Disease-Modifying Antirheumatic Drugs in Pregnancy and Reproductive Health for Patients With Rheumatic Disease: A Scoping Review. Arthritis Care Res (Hoboken). 2025;77:1273-1281. PMID 40256995 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Sullivan DI, et al. Rheumatoid Arthritis-Associated Interstitial Lung Disease (RA-ILD): Update on Prevalence, Risk Factors, Pathogenesis, and Therapy. Curr Rheumatol Rep. 2024;26:431-449. PMID 39320427 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Yao C, et al. Rheumatoid arthritis-associated interstitial lung disease: clinical predictive model and external validation. Respir Res. 2025;26:331. PMID 41299487 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Krishna Boppana T, et al. Rituximab for rheumatoid arthritis-related interstitial lung disease: A systematic review and meta-analysis. Arch Rheumatol. 2024;39:317-329. PMID 38933731 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Provan SA, et al. Interstitial Lung Disease in Patients With Rheumatoid Arthritis or Psoriatic Arthritis Initiating Biologics and Controls: Data From 5 Nordic Registries. J Rheumatol. 2024;51:1111-1118. PMID 39218450 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Earwood JS, et al. Septic Arthritis: Diagnosis and Treatment. Am Fam Physician. 2021;104:589-597. PMID 34913662 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Margaretten ME, et al. Does this adult patient have septic arthritis?. JAMA. 2007;297:1478-88. PMID 17405973 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Shlobin NA, et al. Cervical spine manifestations of rheumatoid arthritis: a review. Neurosurg Rev. 2021;44:1957-1965. PMID 33037539 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Joaquim AF, et al. Cervical spine involvement in rheumatoid arthritis--a systematic review. Autoimmun Rev. 2014;13:1195-202. PMID 25151973 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md
• Friedman MA, et al. Vaccinations for rheumatoid arthritis. Curr Opin Rheumatol. 2016;28:330-6. PMID 26986246 — tags: [rheumatoid-arthritis, extra-articular-and-comorbid-disease] — cited by: extra-articular-and-comorbid-disease.md, ra-associated-interstitial-lung-disease.md, red-flags-and-safety-concerns.md

Trials and patient experience

Deepening additions — 2026-08-30

• Schoels M, et al. Treating rheumatoid arthritis to target: evidence-based recommendations for enhanced disease management. Reumatol Clin. 2012;8:1-2. PMID 22089062 — tags: [rheumatoid-arthritis, guidelines, treat-to-target] — cited by: literature/guidelines/REGISTRY.md
• Smolen JS, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis. 2017;76:960-977. PMID 28264816 — tags: [rheumatoid-arthritis, guidelines, superseded] — cited by: literature/guidelines/REGISTRY.md
• Smolen JS, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis. 2020;79:685-699. PMID 31969328 — tags: [rheumatoid-arthritis, guidelines, superseded] — cited by: literature/guidelines/REGISTRY.md
• Crotti C, et al. The Italian Society for Rheumatology guidelines for the treatment of patients with rheumatoid arthritis and interstitial lung disease. Reumatismo. 2026;78:10.4081/reumatismo.2025.1865. PMID 41247141 — tags: [rheumatoid-arthritis, guidelines, ra-ild] — cited by: literature/guidelines/REGISTRY.md
• Smolen JS, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biologic disease-modifying antirheumatic drugs: 2025 update. Ann Rheum Dis. 2026;85:991-1009. PMID 41826212 — tags: [rheumatoid-arthritis, guidelines] — cited by: guidelines.md
• Navarro-Sarabia F, et al. Adalimumab for treating rheumatoid arthritis. Cochrane Database Syst Rev. 2005;2005:CD005113. PMID 16034967 — tags: [rheumatoid-arthritis, deepening] — cited by: biologic-dmards.md
• Goekoop-Ruiterman YP, et al. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. Arthritis Rheum. 2005;52:3381-90. PMID 16258899 — tags: [rheumatoid-arthritis, deepening] — cited by: treat-to-target-and-remission.md
• Burton W, et al. Systematic review of studies of productivity loss due to rheumatoid arthritis. Occup Med (Lond). 2006;56:18-27. PMID 16286432 — tags: [rheumatoid-arthritis, deepening] — cited by: epidemiology-and-burden.md
• Zintzaras E, et al. The risk of lymphoma development in autoimmune diseases: a meta-analysis. Arch Intern Med. 2005;165:2337-44. PMID 16287762 — tags: [rheumatoid-arthritis, deepening] — cited by: extra-articular-and-comorbid-disease.md
• Emery P, et al. The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial. Arthritis Rheum. 2006;54:1390-400. PMID 16649186 — tags: [rheumatoid-arthritis, deepening] — cited by: biologic-dmards.md
• Verstappen SM, et al. Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial). Ann Rheum Dis. 2007;66:1443-9. PMID 17519278 — tags: [rheumatoid-arthritis, deepening] — cited by: treat-to-target-and-remission.md
• Nishimura K, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007;146:797-808. PMID 17548411 — tags: [rheumatoid-arthritis, deepening] — cited by: classification-and-diagnosis.md
• Visser K, et al. Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature. Ann Rheum Dis. 2009;68:1094-9. PMID 19033290 — tags: [rheumatoid-arthritis, deepening] — cited by: conventional-dmards.md
• Bos WH, et al. Effect of dexamethasone on autoantibody levels and arthritis development in patients with arthralgia: a randomised trial. Ann Rheum Dis. 2010;69:571-4. PMID 19363022 — tags: [rheumatoid-arthritis, deepening] — cited by: preclinical-autoimmunity-and-prevention.md
• Singh JA, et al. Golimumab for rheumatoid arthritis. Cochrane Database Syst Rev. 2010;2010:CD008341. PMID 20091667 — tags: [rheumatoid-arthritis, deepening] — cited by: biologic-dmards.md
• Katchamart W, et al. Systematic monitoring of disease activity using an outcome measure improves outcomes in rheumatoid arthritis. J Rheumatol. 2010;37:1411-5. PMID 20436069 — tags: [rheumatoid-arthritis, deepening] — cited by: treat-to-target-and-remission.md
• Meune C, et al. High risk of clinical cardiovascular events in rheumatoid arthritis: Levels of associations of myocardial infarction and stroke through a systematic review and meta-analysis. Arch Cardiovasc Dis. 2010;103:253-61. PMID 20656636 — tags: [rheumatoid-arthritis, deepening] — cited by: extra-articular-and-comorbid-disease.md, overview.md
• Bøyesen P, et al. MRI in early rheumatoid arthritis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progression. Ann Rheum Dis. 2011;70:428-33. PMID 20810395 — tags: [rheumatoid-arthritis, deepening] — cited by: biomarkers-and-tissue-precision.md
• Campbell L, et al. Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of randomized controlled trials. Rheumatology (Oxford). 2011;50:552-62. PMID 21078627 — tags: [rheumatoid-arthritis, deepening] — cited by: biologic-dmards.md
• Duer-Jensen A, et al. Bone edema on magnetic resonance imaging is an independent predictor of rheumatoid arthritis development in patients with early undifferentiated arthritis. Arthritis Rheum. 2011;63:2192-202. PMID 21484772 — tags: [rheumatoid-arthritis, deepening] — cited by: classification-and-diagnosis.md
• Kremer JM, et al. Long-term safety, efficacy and inhibition of radiographic progression with abatacept treatment in patients with rheumatoid arthritis and an inadequate response to methotrexate: 3-year results from the AIM trial. Ann Rheum Dis. 2011;70:1826-30. PMID 21893583 — tags: [rheumatoid-arthritis, deepening] — cited by: biologic-dmards.md
• Stack RJ, et al. Delays in help seeking at the onset of the symptoms of rheumatoid arthritis: a systematic synthesis of qualitative literature. Ann Rheum Dis. 2012;71:493-7. PMID 22121128 — tags: [rheumatoid-arthritis, deepening] — cited by: patient-experience-and-advocacy.md
• Moreland LW, et al. A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial. Arthritis Rheum. 2012;64:2824-35. PMID 22508468 — tags: [rheumatoid-arthritis, deepening] — cited by: conventional-dmards.md
• Porter D, et al. Intensive management of early rheumatoid arthritis: the TICORA and TEAR studies. Clin Exp Rheumatol. 2012;30:S32-4. PMID 23078791 — tags: [rheumatoid-arthritis, deepening] — cited by: treat-to-target-and-remission.md
• Townsend A, et al. A qualitative interview study: patient accounts of medication use in early rheumatoid arthritis from symptom onset to early postdiagnosis. BMJ Open. 2013;3:e002164. PMID 23408077 — tags: [rheumatoid-arthritis, deepening] — cited by: patient-experience-and-advocacy.md
• Sakellariou G, et al. Performance of the 2010 classification criteria for rheumatoid arthritis: a systematic literature review and a meta-analysis. PLoS One. 2013;8:e56528. PMID 23437156 — tags: [rheumatoid-arthritis, deepening] — cited by: classification-and-diagnosis.md
• Svendsen AJ, et al. On the origin of rheumatoid arthritis: the impact of environment and genes--a population based twin study. PLoS One. 2013;8:e57304. PMID 23468964 — tags: [rheumatoid-arthritis, deepening] — cited by: genetics-environment-and-mucosal-origins.md
• Radner H, et al. Performance of the 2010 ACR/EULAR classification criteria for rheumatoid arthritis: a systematic literature review. Ann Rheum Dis. 2014;73:114-23. PMID 23592710 — tags: [rheumatoid-arthritis, deepening] — cited by: classification-and-diagnosis.md, overview.md
• O'Dell JR, et al. Therapies for active rheumatoid arthritis after methotrexate failure. N Engl J Med. 2013;369:307-18. PMID 23755969 — tags: [rheumatoid-arthritis, deepening] — cited by: conventional-dmards.md, guidelines.md
• Matcham F, et al. The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis. Rheumatology (Oxford). 2013;52:2136-48. PMID 24003249 — tags: [rheumatoid-arthritis, deepening] — cited by: epidemiology-and-burden.md, extra-articular-and-comorbid-disease.md, overview.md
• Sun J, et al. Diagnostic accuracy of combined tests of anti cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis: a meta-analysis. Clin Exp Rheumatol. 2014;32:11-21. PMID 24050751 — tags: [rheumatoid-arthritis, deepening] — cited by: classification-and-diagnosis.md
• de Rooy DP, et al. Smoking as a risk factor for the radiological severity of rheumatoid arthritis: a study on six cohorts. Ann Rheum Dis. 2014;73:1384-7. PMID 24389296 — tags: [rheumatoid-arthritis, deepening] — cited by: biomarkers-and-tissue-precision.md
• Goodman SM, et al. Outcomes related to methotrexate dose and route of administration in patients with rheumatoid arthritis: a systematic literature review. Clin Exp Rheumatol. 2015;33:272-8. PMID 25536122 — tags: [rheumatoid-arthritis, deepening] — cited by: conventional-dmards.md
• van Steenbergen HW, et al. Association of valine and leucine at HLA-DRB1 position 11 with radiographic progression in rheumatoid arthritis, independent of the shared epitope alleles but not independent of anti-citrullinated protein antibodies. Arthritis Rheumatol. 2015;67:877-86. PMID 25580908 — tags: [rheumatoid-arthritis, deepening] — cited by: biomarkers-and-tissue-precision.md
• Molina E, et al. Association of socioeconomic status with treatment delays, disease activity, joint damage, and disability in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2015;67:940-6. PMID 25581770 — tags: [rheumatoid-arthritis, deepening] — cited by: classification-and-diagnosis.md
• Verschueren P, et al. Patients lacking classical poor prognostic markers might also benefit from a step-down glucocorticoid bridging scheme in early rheumatoid arthritis: week 16 results from the randomized multicenter CareRA trial. Arthritis Res Ther. 2015;17:97. PMID 25889222 — tags: [rheumatoid-arthritis, deepening] — cited by: conventional-dmards.md
• Rudan I, et al. Prevalence of rheumatoid arthritis in low- and middle-income countries: A systematic review and analysis. J Glob Health. 2015;5:010409. PMID 25969732 — tags: [rheumatoid-arthritis, deepening] — cited by: epidemiology-and-burden.md
• Usenbo A, et al. Prevalence of Arthritis in Africa: A Systematic Review and Meta-Analysis. PLoS One. 2015;10:e0133858. PMID 26241756 — tags: [rheumatoid-arthritis, deepening] — cited by: epidemiology-and-burden.md
• Simon TA, et al. Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis. Arthritis Res Ther. 2015;17:212. PMID 26271620 — tags: [rheumatoid-arthritis, deepening] — cited by: extra-articular-and-comorbid-disease.md
• Jiang X, et al. An Immunochip-based interaction study of contrasting interaction effects with smoking in ACPA-positive versus ACPA-negative rheumatoid arthritis. Rheumatology (Oxford). 2016;55:149-55. PMID 26272072 — tags: [rheumatoid-arthritis, deepening] — cited by: genetics-environment-and-mucosal-origins.md
• van Steenbergen HW, et al. Clinical factors, anticitrullinated peptide antibodies and MRI-detected subclinical inflammation in relation to progression from clinically suspect arthralgia to arthritis. Ann Rheum Dis. 2016;75:1824-30. PMID 26613769 — tags: [rheumatoid-arthritis, deepening] — cited by: preclinical-autoimmunity-and-prevention.md
• Bougea A, et al. A Systematic Review of Peripheral and Central Nervous System Involvement of Rheumatoid Arthritis, Systemic Lupus Erythematosus, Primary Sjögren's Syndrome, and Associated Immunological Profiles. Int J Chronic Dis. 2015;2015:910352. PMID 26688829 — tags: [rheumatoid-arthritis, deepening] — cited by: extra-articular-and-comorbid-disease.md
• Terao C, et al. A twin study of rheumatoid arthritis in the Japanese population. Mod Rheumatol. 2016;26:685-9. PMID 26727555 — tags: [rheumatoid-arthritis, deepening] — cited by: genetics-environment-and-mucosal-origins.md
• Jalal H, et al. Cost-Effectiveness of Triple Therapy Versus Etanercept Plus Methotrexate in Early Aggressive Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2016;68:1751-1757. PMID 27015606 — tags: [rheumatoid-arthritis, deepening] — cited by: conventional-dmards.md
• Dale J, et al. Targeting ultrasound remission in early rheumatoid arthritis: the results of the TaSER study, a randomised clinical trial. Ann Rheum Dis. 2016;75:1043-50. PMID 27026689 — tags: [rheumatoid-arthritis, deepening] — cited by: treat-to-target-and-remission.md
• Smolen JS, et al. Discordance between patient and physician assessments of global disease activity in rheumatoid arthritis and association with work productivity. Arthritis Res Ther. 2016;18:114. PMID 27209012 — tags: [rheumatoid-arthritis, deepening] — cited by: patient-experience-and-advocacy.md
• Koopman FA, et al. Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2016;113:8284-9. PMID 27382171 — tags: [rheumatoid-arthritis, deepening] — cited by: clinical-trials-landscape.md
• Haavardsholm EA, et al. Ultrasound in management of rheumatoid arthritis: ARCTIC randomised controlled strategy trial. BMJ. 2016;354:i4205. PMID 27530741 — tags: [rheumatoid-arthritis, deepening] — cited by: treat-to-target-and-remission.md
• Lage-Hansen PR, et al. The role of ultrasound in diagnosing rheumatoid arthritis, what do we know? An updated review. Rheumatol Int. 2017;37:179-187. PMID 27803965 — tags: [rheumatoid-arthritis, deepening] — cited by: classification-and-diagnosis.md
• Minozzi S, et al. Risk of infections using anti-TNF agents in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: a systematic review and meta-analysis. Expert Opin Drug Saf. 2016;15:11-34. PMID 27924643 — tags: [rheumatoid-arthritis, deepening] — cited by: red-flags-and-safety-concerns.md
• Burmester GR, et al. A randomised phase IIb study of mavrilimumab, a novel GM-CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis. Ann Rheum Dis. 2017;76:1020-1030. PMID 28213566 — tags: [rheumatoid-arthritis, deepening] — cited by: clinical-trials-landscape.md
• Jørgensen KK, et al. Switching from originator infliximab to biosimilar CT-P13 compared with maintained treatment with originator infliximab (NOR-SWITCH): a 52-week, randomised, double-blind, non-inferiority trial. Lancet. 2017;389:2304-2316. PMID 28502609 — tags: [rheumatoid-arthritis, deepening] — cited by: biologic-dmards.md
• Zhang Q, et al. Rheumatoid arthritis is associated with negatively variable impacts on domains of female sexual function: evidence from a systematic review and meta-analysis. Psychol Health Med. 2018;23:114-125. PMID 28635309 — tags: [rheumatoid-arthritis, deepening] — cited by: patient-experience-and-advocacy.md
• Weinblatt ME, et al. A Randomized Phase IIb Study of Mavrilimumab and Golimumab in Rheumatoid Arthritis. Arthritis Rheumatol. 2018;70:49-59. PMID 28941039 — tags: [rheumatoid-arthritis, deepening] — cited by: clinical-trials-landscape.md
• de Hair MJH, et al. Difficult-to-treat rheumatoid arthritis: an area of unmet clinical need. Rheumatology (Oxford). 2018;57:1135-1144. PMID 29029308 — tags: [rheumatoid-arthritis, deepening] — cited by: difficult-to-treat-and-refractory-ra.md
• Park JK, et al. Impact of temporary methotrexate discontinuation for 2 weeks on immunogenicity of seasonal influenza vaccination in patients with rheumatoid arthritis: a randomised clinical trial. Ann Rheum Dis. 2018;77:898-904. PMID 29572291 — tags: [rheumatoid-arthritis, deepening] — cited by: red-flags-and-safety-concerns.md
• Tasaki S, et al. Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission. Nat Commun. 2018;9:2755. PMID 30013029 — tags: [rheumatoid-arthritis, deepening] — cited by: biomarkers-and-tissue-precision.md, synovial-immunobiology.md
• Holers VM, et al. Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction. Nat Rev Rheumatol. 2018;14:542-557. PMID 30111803 — tags: [rheumatoid-arthritis, deepening] — cited by: genetics-environment-and-mucosal-origins.md
• Archer R, et al. Assessing prognosis and prediction of treatment response in early rheumatoid arthritis: systematic reviews. Health Technol Assess. 2018;22:1-294. PMID 30501821 — tags: [rheumatoid-arthritis, deepening] — cited by: biomarkers-and-tissue-precision.md
• Gerlag DM, et al. Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study. Ann Rheum Dis. 2019;78:179-185. PMID 30504445 — tags: [rheumatoid-arthritis, deepening] — cited by: preclinical-autoimmunity-and-prevention.md
• Curtis JR, et al. Adjustment of the multi-biomarker disease activity score to account for age, sex and adiposity in patients with rheumatoid arthritis. Rheumatology (Oxford). 2019;58:874-883. PMID 30590790 — tags: [rheumatoid-arthritis, deepening] — cited by: biomarkers-and-tissue-precision.md
• Durand C, et al. Patient Preferences for Disease-modifying Antirheumatic Drug Treatment in Rheumatoid Arthritis: A Systematic Review. J Rheumatol. 2020;47:176-187. PMID 30988125 — tags: [rheumatoid-arthritis, deepening] — cited by: patient-experience-and-advocacy.md
• Genovese MC, et al. Effect of Filgotinib vs Placebo on Clinical Response in Patients With Moderate to Severe Rheumatoid Arthritis Refractory to Disease-Modifying Antirheumatic Drug Therapy: The FINCH 2 Randomized Clinical Trial. JAMA. 2019;322:315-325. PMID 31334793 — tags: [rheumatoid-arthritis, deepening] — cited by: jak-inhibitors-and-targeted-therapy.md
• Furer V, et al. 2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases. Ann Rheum Dis. 2020;79:39-52. PMID 31413005 — tags: [rheumatoid-arthritis, deepening] — cited by: guidelines.md
• Xie W, et al. A meta-analysis of biologic therapies on risk of new or recurrent cancer in patients with rheumatoid arthritis and a prior malignancy. Rheumatology (Oxford). 2020;59:930-939. PMID 31620795 — tags: [rheumatoid-arthritis, deepening] — cited by: red-flags-and-safety-concerns.md
• Sammaritano LR, et al. 2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases. Arthritis Care Res (Hoboken). 2020;72:461-488. PMID 32090466 — tags: [rheumatoid-arthritis, deepening] — cited by: guidelines.md
• Hsieh PH, et al. Economic burden of rheumatoid arthritis: a systematic review of literature in biologic era. Ann Rheum Dis. 2020;79:771-777. PMID 32245893 — tags: [rheumatoid-arthritis, deepening] — cited by: epidemiology-and-burden.md, overview.md
• Zhang L, et al. Rheumatoid arthritis is associated with negatively variable impacts on domains of sleep disturbances: evidence from a systematic review and meta-analysis. Psychol Health Med. 2021;26:267-277. PMID 32420757 — tags: [rheumatoid-arthritis, deepening] — cited by: patient-experience-and-advocacy.md
• Qiao Y, et al. Rheumatoid arthritis risk in periodontitis patients: A systematic review and meta-analysis. Joint Bone Spine. 2020;87:556-564. PMID 32593704 — tags: [rheumatoid-arthritis, deepening] — cited by: genetics-environment-and-mucosal-origins.md
• Mehri F, et al. The association Between Occupational Exposure to silica and Risk of Developing Rheumatoid Arthritis: A Meta-Analysis. Saf Health Work. 2020;11:136-142. PMID 32596007 — tags: [rheumatoid-arthritis, deepening] — cited by: genetics-environment-and-mucosal-origins.md
• Juge PA, et al. Methotrexate and rheumatoid arthritis associated interstitial lung disease. Eur Respir J. 2021;57:2000337. PMID 32646919 — tags: [rheumatoid-arthritis, deepening] — cited by: ra-associated-interstitial-lung-disease.md
• Wang D, et al. Diagnostic accuracy of 14-3-3 η protein in rheumatoid arthritis: A meta-analysis. Int J Rheum Dis. 2020;23:1443-1451. PMID 32909672 — tags: [rheumatoid-arthritis, deepening] — cited by: biomarkers-and-tissue-precision.md
• Yates M, et al. Venous Thromboembolism Risk With JAK Inhibitors: A Meta-Analysis. Arthritis Rheumatol. 2021;73:779-788. PMID 33174384 — tags: [rheumatoid-arthritis, deepening] — cited by: jak-inhibitors-and-targeted-therapy.md
• Almutairi K, et al. The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review. Rheumatol Int. 2021;41:863-877. PMID 33175207 — tags: [rheumatoid-arthritis, deepening] — cited by: epidemiology-and-burden.md, overview.md
• Rogier C, et al. Subclinical synovitis in arthralgia: how often does it result in clinical arthritis? Reflecting on starting points for disease-modifying anti-rheumatic drug treatment. Rheumatology (Oxford). 2021;60:3872-3878. PMID 33331633 — tags: [rheumatoid-arthritis, deepening] — cited by: preclinical-autoimmunity-and-prevention.md
• Westhovens R, et al. Filgotinib in combination with methotrexate or as monotherapy versus methotrexate monotherapy in patients with active rheumatoid arthritis and limited or no prior exposure to methotrexate: the phase 3, randomised controlled FINCH 3 trial. Ann Rheum Dis. 2021;80:727-738. PMID 33452004 — tags: [rheumatoid-arthritis, deepening] — cited by: jak-inhibitors-and-targeted-therapy.md
• Roodenrijs NMT, et al. Non-adherence in difficult-to-treat rheumatoid arthritis from the perspectives of patients and rheumatologists: a concept mapping study. Rheumatology (Oxford). 2021;60:5105-5116. PMID 33560301 — tags: [rheumatoid-arthritis, deepening] — cited by: difficult-to-treat-and-refractory-ra.md
• Sun KJ, et al. Methotrexate can prevent cardiovascular events in patients with rheumatoid arthritis: An updated meta-analysis. Medicine (Baltimore). 2021;100:e24579. PMID 33607787 — tags: [rheumatoid-arthritis, deepening] — cited by: extra-articular-and-comorbid-disease.md
• Morotti A, et al. Systematic Review and Meta-analysis on the Association of Occupational Exposure to Free Crystalline Silica and Rheumatoid Arthritis. Clin Rev Allergy Immunol. 2022;62:333-345. PMID 33651342 — tags: [rheumatoid-arthritis, deepening] — cited by: genetics-environment-and-mucosal-origins.md
• van Boheemen L, et al. Atorvastatin is unlikely to prevent rheumatoid arthritis in high risk individuals: results from the prematurely stopped STAtins to Prevent Rheumatoid Arthritis (STAPRA) trial. RMD Open. 2021;7:e001591. PMID 33685928 — tags: [rheumatoid-arthritis, deepening] — cited by: preclinical-autoimmunity-and-prevention.md
• Alves C, et al. The Risk of Infections Associated With JAK Inhibitors in Rheumatoid Arthritis: A Systematic Review and Network Meta-analysis. J Clin Rheumatol. 2022;28:e407-e414. PMID 33902098 — tags: [rheumatoid-arthritis, deepening] — cited by: jak-inhibitors-and-targeted-therapy.md
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