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Curation log — asthma

2026-08-28 — Seed

  • Created: four seed files, 18 canonical pages, overview with 26 PMIDs, and 7 seed questions.
  • Searches run (live PubMed E-utilities esearch/esummary): diagnosis and GBD; type-2/non-type-2 immunology, endotypes, genetics and environment; SYGMA/Novel START and SMART; SABINA; omalizumab, mepolizumab, benralizumab, dupilumab and tezepelumab; oral-steroid harms; thermoplasty, immunotherapy and pregnancy; attack prediction and remission.
  • Verification: all cited PMIDs were returned live. Three recalled guideline/childhood-asthma identifiers returned unrelated papers and were excluded.
  • Next: full build queued per CONDITIONS-ROADMAP.md.

2026-08-29 — Full build

  • Built all 18 planned pages: diagnosis; epidemiology; airway biology; genetics/environment/prevention; phenotypes/endotypes/treatable traits; mild/moderate disease; severe asthma/biologics; exacerbations; inhaler technique/adherence/self-management; children; pregnancy; comorbidity/mimics; guidelines; biomarkers; trials; patient experience; safety; and the expanded overview.
  • Page depth: every wiki page is 150–400 lines. Seventeen pages carry 25–32 unique PubMed citations; the trials landscape carries 16 PubMed citations plus 15 live-verified ClinicalTrials.gov records.
  • Literature layer: generated a 394-record master bibliography with page provenance; wrote six landmark-study notes; built current guideline and quantitative-statistics registries; and added a four-file patient-voice layer with public-source ethics, organization verification and a two-source minimum for themes.
  • Research frontier: replaced the seed list with 24 stable, tiered open questions and a 14-row “Dots not yet connected” junction table.
  • Live literature work: ran broad and focused PubMed E-utilities searches across every page domain, then resolved every cited PMID from the live records cache before use. Queried ClinicalTrials.gov API v2 across six asthma trial searches, yielding 482 unique live records used to verify every cited NCT ID.
  • Current guidance checked live: GINA 2026 Strategy and Summary Guide; BTS/NICE/SIGN NG245; NHLBI/NAEPP 2020 focused updates; Australian Asthma Handbook v3.0; and WHO PEN.
  • Patient organizations checked live: Asthma Australia, Asthma + Lung UK, Asthma Canada, Allergy & Asthma Network and GAAPP.
  • Preventive citation control: an exact-ID PubMed check exposed several plausible but unrelated recalled PMIDs. They were excluded, and final validation now compares every PMID to live metadata, every NCT to the live ClinicalTrials.gov cache, inline author/year to PubMed authorship, and in-text citations to each page's reference list.
  • Could not verify / coverage limits: the English-language patient-organization search did not establish representative coverage for Africa, South Asia, Latin America or most of continental Europe, so no absence claim was made. Registry recruitment status was treated as provisional, and this build did not independently audit every quantitative claim against full text; that remains the required separate audit.
  • Verification: 18/18 planned pages exist; 394/394 unique wiki PMIDs resolve in the session cache; 15/15 NCT IDs resolve in the session API cache; all local Markdown links resolve; all in-text PMID citations have corresponding page references; and asthma is marked built in the roadmap.
  • Next: independent citation/content audit before any page status moves from draft to curated.

2026-08-30 — Independent audit

  • Scope completed: audited 18/18 wiki pages and every asthma literature artifact: the 401-record bibliography, six landmark notes, guideline registry, statistics register, and four patient-voice files.
  • Citation volume checked: re-fetched all 401 unique PMIDs through live PubMed E-utilities summary and full-record queries and reviewed 1,645 pre-audit PMID occurrences in context. After bibliography and evidence-gap corrections, the condition contains 1,707 exact PMID occurrences; all resolve to the same 401 live records and every wiki in-text PMID has a matching page reference.
  • Trial-registry volume checked: re-fetched all 15 originally cited NCT records individually through ClinicalTrials.gov API v2. Focused repeat searches added four relevant records, producing a final set of 19/19 individually resolved NCT IDs.
  • Errors found and fixed: 10 discrete citation/content issues. Seven live-verified guideline PMIDs used by the condition were absent from the master bibliography and were added. One asthma-death uncertainty interval could not be reproduced from the cited live record and was removed while retaining the supported point estimate with a caveat. One stale statement implying no biologic-withdrawal trial was corrected after NCT06818019 was found. One pregnancy evidence-gap statement was sharpened after live records for omalizumab, dupilumab and benralizumab pregnancy-exposure studies were found (NCT00373061, NCT04173442 and NCT03794999).
  • Absence claims re-searched: repeated live searches for direct biologic comparisons, biologic withdrawal, type-2-low targeted therapy, primary prevention, biologics in pregnancy, diagnostic test combinations, biomarker validation, social-media harm evidence, digital-monitoring mortality and low-resource AIR/MART implementation. Claims were converted to dated descriptions of what the searches did find and what outcome evidence remains missing; no claim of universal nonexistence remains.
  • External-source checks: rechecked the current GINA, BTS/NICE/SIGN, NHLBI/NAEPP, Australian Asthma Handbook and WHO sources, plus every patient-organization source used in the patient-voice layer. Access/verification dates were synchronized to 2026-08-30.
  • Remaining flags: none. No unresolved verification marker, unresolved PMID/NCT identifier, broken local Markdown link, unmatched wiki citation or substantive audit issue remains.
  • Promotion decision: all 18 pages passed. Every wiki page is now status: curated with last-curated: 2026-08-30; the master index and roadmap are audited.
  • Final validation: page lengths remain within the required 150–400-line range (167–230 lines); all required TL;DR, open-question, related-page and reference sections are present; 401/401 exact PMIDs and 19/19 exact NCT IDs resolve live; all 401 bibliography identifiers cover the condition corpus; and all local links resolve.