Master bibliography — colorectal adenocarcinoma

Last curated: 2026-08-30

Scope. 304 unique papers cited across the 18 wiki pages and supporting literature layer. All 304 PMIDs were re-retrieved through live PubMed E-utilities in the 2026-08-30 audit session. Entries are grouped by first major use; cited by records every condition file that cites the paper.

Foundations and reviews

• Vogelstein B, et al. Genetic alterations during colorectal-tumor development. N Engl J Med. 1988;319(9):525-32. PMID 2841597 — tags: [foundations-reviews] — cited by: INDEX.md, literature/notes/vogelstein-1988-sequence.md, wiki/adenoma-carcinoma-and-serrated-pathways.md, wiki/overview.md
• MERCURY Study Group. Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. BMJ. 2006;333(7572):779. PMID 16984925 — tags: [foundations-reviews] — cited by: literature/statistics/STATISTICS.md, wiki/localized-rectal-cancer.md, wiki/overview.md, wiki/pathology-staging-and-diagnostic-workup.md
• Chang GJ, et al. Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst. 2007;99(6):433-41. PMID 17374833 — tags: [foundations-reviews, systematic-review, survivorship] — cited by: literature/statistics/STATISTICS.md, wiki/biomarkers-and-liquid-biopsy.md, wiki/guidelines.md, wiki/localized-colon-cancer.md, wiki/overview.md, wiki/pathology-staging-and-diagnostic-workup.md
• Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012;487(7407):330-7. PMID 22810696 — tags: [foundations-reviews] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md, wiki/molecular-subtypes-and-tumor-microenvironment.md, wiki/overview.md, wiki/pathology-staging-and-diagnostic-workup.md
• Zauber AG, et al. Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths. N Engl J Med. 2012;366(8):687-96. PMID 22356322 — tags: [foundations-reviews] — cited by: literature/statistics/STATISTICS.md, wiki/adenoma-carcinoma-and-serrated-pathways.md, wiki/overview.md, wiki/screening-and-early-detection.md
• Nordlinger B, et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2013;14(12):1208-15. PMID 24120480 — tags: [foundations-reviews, randomized-trial] — cited by: literature/statistics/STATISTICS.md, wiki/clinical-trials-landscape.md, wiki/guidelines.md, wiki/liver-and-lung-metastasis.md, wiki/overview.md
• Corley DA, et al. Adenoma detection rate and risk of colorectal cancer and death. N Engl J Med. 2014;370(14):1298-306. PMID 24693890 — tags: [foundations-reviews] — cited by: literature/statistics/STATISTICS.md, wiki/adenoma-carcinoma-and-serrated-pathways.md, wiki/overview.md, wiki/screening-and-early-detection.md
• Imperiale TF, et al. Multitarget stool DNA testing for colorectal-cancer screening. N Engl J Med. 2014;370(14):1287-97. PMID 24645800 — tags: [foundations-reviews, screening] — cited by: wiki/overview.md, wiki/screening-and-early-detection.md
• Kloor M, et al. Clinical significance of microsatellite instability in colorectal cancer. Langenbecks Arch Surg. 2014;399(1):23-31. PMID 24048684 — tags: [foundations-reviews, msi] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md, wiki/overview.md, wiki/pathology-staging-and-diagnostic-workup.md
• Lee JK, et al. Accuracy of fecal immunochemical tests for colorectal cancer: systematic review and meta-analysis. Ann Intern Med. 2014;160(3):171. PMID 24658694 — tags: [foundations-reviews, meta-analysis, systematic-review] — cited by: literature/statistics/STATISTICS.md, wiki/overview.md, wiki/screening-and-early-detection.md
• André T, et al. Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study. J Clin Oncol. 2015;33(35):4176-87. PMID 26527776 — tags: [foundations-reviews, survivorship] — cited by: INDEX.md, OPEN-QUESTIONS.md, literature/notes/andre-2015-mosaic.md, literature/statistics/STATISTICS.md, wiki/localized-colon-cancer.md, wiki/overview.md
• El-Shami K, et al. American Cancer Society Colorectal Cancer Survivorship Care Guidelines. CA Cancer J Clin. 2015;65(6):428-55. PMID 26348643 — tags: [foundations-reviews, guideline, survivorship] — cited by: literature/guidelines/REGISTRY.md, wiki/overview.md, wiki/survivorship-and-late-effects.md
• Guinney J, et al. The consensus molecular subtypes of colorectal cancer. Nat Med. 2015;21(11):1350-6. PMID 26457759 — tags: [foundations-reviews] — cited by: OPEN-QUESTIONS.md, literature/notes/guinney-2015-cms.md, wiki/biomarkers-and-liquid-biopsy.md, wiki/molecular-subtypes-and-tumor-microenvironment.md, wiki/overview.md
• O'Brien MJ, Zhao Q, Yang S. Colorectal serrated pathway cancers and precursors. Histopathology. 2015;66(1):49-65. PMID 25263173 — tags: [foundations-reviews] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md, wiki/overview.md, wiki/pathology-staging-and-diagnostic-workup.md
• Lugli A, et al. Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016. Mod Pathol. 2017;30(9):1299-1311. PMID 28548122 — tags: [foundations-reviews] — cited by: literature/guidelines/REGISTRY.md, wiki/biomarkers-and-liquid-biopsy.md, wiki/guidelines.md, wiki/overview.md, wiki/pathology-staging-and-diagnostic-workup.md
• De Palma FDE, et al. The Molecular Hallmarks of the Serrated Pathway in Colorectal Cancer. Cancers (Basel). 2019;11(7). PMID 31330830 — tags: [foundations-reviews] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md, wiki/molecular-subtypes-and-tumor-microenvironment.md, wiki/overview.md
• Ganesh K, et al. Immunotherapy in colorectal cancer: rationale, challenges and potential. Nat Rev Gastroenterol Hepatol. 2019;16(6):361-375. PMID 30886395 — tags: [foundations-reviews] — cited by: wiki/clinical-trials-landscape.md, wiki/molecular-subtypes-and-tumor-microenvironment.md, wiki/overview.md
• Keum N, Giovannucci E. Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nat Rev Gastroenterol Hepatol. 2019;16(12):713-732. PMID 31455888 — tags: [foundations-reviews] — cited by: wiki/epidemiology-and-burden.md, wiki/overview.md
• Treasure T, et al. Pulmonary Metastasectomy versus Continued Active Monitoring in Colorectal Cancer (PulMiCC): a multicentre randomised clinical trial. Trials. 2019;20(1):718. PMID 31831062 — tags: [foundations-reviews, randomized-trial] — cited by: wiki/liver-and-lung-metastasis.md, wiki/overview.md
• André T, et al. Pembrolizumab in Microsatellite-Instability-High Advanced Colorectal Cancer. N Engl J Med. 2020;383(23):2207-2218. PMID 33264544 — tags: [foundations-reviews, msi] — cited by: OPEN-QUESTIONS.md, literature/notes/andre-2020-keynote177.md, literature/statistics/STATISTICS.md, wiki/metastatic-systemic-therapy.md, wiki/overview.md, wiki/precision-oncology.md
• André T, et al. Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. Lancet Oncol. 2020;21(12):1620-1629. PMID 33271092 — tags: [foundations-reviews, randomized-trial] — cited by: OPEN-QUESTIONS.md, wiki/guidelines.md, wiki/localized-colon-cancer.md, wiki/overview.md
• Bridgewater JA, et al. Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial. Lancet Oncol. 2020;21(3):398-411. PMID 32014119 — tags: [foundations-reviews, randomized-trial] — cited by: wiki/clinical-trials-landscape.md, wiki/guidelines.md, wiki/liver-and-lung-metastasis.md, wiki/overview.md
• Cremolini C, et al. Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial. Lancet Oncol. 2020;21(4):497-507. PMID 32164906 — tags: [foundations-reviews, randomized-trial] — cited by: OPEN-QUESTIONS.md, literature/statistics/STATISTICS.md, wiki/metastatic-systemic-therapy.md, wiki/overview.md
• He X, et al. Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps. Gastroenterology. 2020;158(4):852-861.e4. PMID 31302144 — tags: [foundations-reviews] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md, wiki/guidelines.md, wiki/overview.md, wiki/screening-and-early-detection.md
• Hong DS, et al. Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials. Lancet Oncol. 2020;21(4):531-540. PMID 32105622 — tags: [foundations-reviews] — cited by: wiki/overview.md, wiki/precision-oncology.md
• Pieniowski EHA, et al. Prevalence of low anterior resection syndrome and impact on quality of life after rectal cancer surgery: population-based study. BJS Open. 2020;4(5):935-942. PMID 32530135 — tags: [foundations-reviews] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/README.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, literature/statistics/STATISTICS.md, wiki/localized-rectal-cancer.md, wiki/overview.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Bahadoer RR, et al. Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial. Lancet Oncol. 2021;22(1):29-42. PMID 33301740 — tags: [foundations-reviews, randomized-trial] — cited by: INDEX.md, OPEN-QUESTIONS.md, literature/statistics/STATISTICS.md, wiki/localized-rectal-cancer.md, wiki/overview.md
• Biller LH, Schrag D. Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review. JAMA. 2021;325(7):669-685. PMID 33591350 — tags: [foundations-reviews] — cited by: INDEX.md, OPEN-QUESTIONS.md, wiki/metastatic-systemic-therapy.md, wiki/overview.md
• Tabernero J, et al. Encorafenib Plus Cetuximab as a New Standard of Care for Previously Treated BRAF V600E-Mutant Metastatic Colorectal Cancer: Updated Survival Results and Subgroup Analyses from the BEACON Study. J Clin Oncol. 2021;39(4):273-284. PMID 33503393 — tags: [foundations-reviews, survivorship] — cited by: literature/statistics/STATISTICS.md, wiki/clinical-trials-landscape.md, wiki/metastatic-systemic-therapy.md, wiki/overview.md, wiki/precision-oncology.md
• US Preventive Services Task Force, et al. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. JAMA. 2021;325(19):1965-1977. PMID 34003218 — tags: [foundations-reviews, screening] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md, wiki/overview.md, wiki/screening-and-early-detection.md
• Bretthauer M, et al. Effect of Colonoscopy Screening on Risks of Colorectal Cancer and Related Death. N Engl J Med. 2022;387(17):1547-1556. PMID 36214590 — tags: [foundations-reviews, screening] — cited by: INDEX.md, OPEN-QUESTIONS.md, literature/statistics/STATISTICS.md, wiki/guidelines.md, wiki/overview.md, wiki/screening-and-early-detection.md
• Coughlin SE, et al. Multigene Panel Testing Yields High Rates of Clinically Actionable Variants Among Patients With Colorectal Cancer. JCO Precis Oncol. 2022;6:e2200517. PMID 36370464 — tags: [foundations-reviews] — cited by: literature/statistics/STATISTICS.md, wiki/epidemiology-and-burden.md, wiki/guidelines.md, wiki/hereditary-syndromes-and-genetics.md, wiki/overview.md, wiki/pathology-staging-and-diagnostic-workup.md
• Eikenboom EL, et al. Universal Immunohistochemistry for Lynch Syndrome: A Systematic Review and Meta-analysis of 58,580 Colorectal Carcinomas. Clin Gastroenterol Hepatol. 2022;20(3):e496-e507. PMID 33887476 — tags: [foundations-reviews, meta-analysis, systematic-review] — cited by: literature/statistics/STATISTICS.md, wiki/biomarkers-and-liquid-biopsy.md, wiki/hereditary-syndromes-and-genetics.md, wiki/overview.md, wiki/pathology-staging-and-diagnostic-workup.md
• Garcia-Aguilar J, et al. Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy. J Clin Oncol. 2022;40(23):2546-2556. PMID 35483010 — tags: [foundations-reviews] — cited by: INDEX.md, OPEN-QUESTIONS.md, wiki/localized-rectal-cancer.md, wiki/overview.md
• Sullivan BA, Noujaim M, Roper J. Cause, Epidemiology, and Histology of Polyps and Pathways to Colorectal Cancer. Gastrointest Endosc Clin N Am. 2022;32(2):177-194. PMID 35361330 — tags: [foundations-reviews] — cited by: INDEX.md, OPEN-QUESTIONS.md, wiki/adenoma-carcinoma-and-serrated-pathways.md, wiki/overview.md
• Tie J, et al. Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer. N Engl J Med. 2022;386(24):2261-2272. PMID 35657320 — tags: [foundations-reviews, ctdna] — cited by: INDEX.md, OPEN-QUESTIONS.md, literature/notes/tie-2022-dynamic.md, literature/statistics/STATISTICS.md, wiki/biomarkers-and-liquid-biopsy.md, wiki/clinical-trials-landscape.md, wiki/guidelines.md, wiki/localized-colon-cancer.md, wiki/overview.md
• Dijkstra EA, et al. Locoregional Failure During and After Short-course Radiotherapy Followed by Chemotherapy and Surgery Compared With Long-course Chemoradiotherapy and Surgery: A 5-Year Follow-up of the RAPIDO Trial. Ann Surg. 2023;278(4):e766-e772. PMID 36661037 — tags: [foundations-reviews] — cited by: literature/statistics/STATISTICS.md, wiki/guidelines.md, wiki/localized-rectal-cancer.md, wiki/overview.md
• Fakih MG, et al. Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C. N Engl J Med. 2023;389(23):2125-2139. PMID 37870968 — tags: [foundations-reviews] — cited by: literature/statistics/STATISTICS.md, wiki/clinical-trials-landscape.md, wiki/overview.md, wiki/precision-oncology.md
• Morgan E, et al. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN. Gut. 2023;72(2):338-344. PMID 36604116 — tags: [foundations-reviews] — cited by: literature/statistics/STATISTICS.md, wiki/epidemiology-and-burden.md, wiki/overview.md
• Rossini D, et al. Primary tumour side as a driver for treatment choice in RAS wild-type metastatic colorectal cancer patients: a systematic review and pooled analysis of randomised trials. Eur J Cancer. 2023;184:106-116. PMID 36913832 — tags: [foundations-reviews, randomized-trial, systematic-review] — cited by: wiki/metastatic-systemic-therapy.md, wiki/overview.md, wiki/precision-oncology.md
• Spaander MCW, et al. Young-onset colorectal cancer. Nat Rev Dis Primers. 2023;9(1):21. PMID 37105987 — tags: [foundations-reviews] — cited by: INDEX.md, OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, literature/statistics/STATISTICS.md, wiki/clinical-trials-landscape.md, wiki/epidemiology-and-burden.md, wiki/overview.md, wiki/patient-experience-and-advocacy.md
• Strickler JH, et al. Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study. Lancet Oncol. 2023;24(5):496-508. PMID 37142372 — tags: [foundations-reviews] — cited by: literature/statistics/STATISTICS.md, wiki/clinical-trials-landscape.md, wiki/overview.md, wiki/precision-oncology.md
• Bray F, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-263. PMID 38572751 — tags: [foundations-reviews] — cited by: literature/statistics/STATISTICS.md, wiki/epidemiology-and-burden.md, wiki/overview.md
• Chung DC, et al. A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening. N Engl J Med. 2024;390(11):973-983. PMID 38477985 — tags: [foundations-reviews, screening] — cited by: literature/statistics/STATISTICS.md, wiki/biomarkers-and-liquid-biopsy.md, wiki/overview.md, wiki/screening-and-early-detection.md
• Doubeni CA, et al. Fecal Immunochemical Test Screening and Risk of Colorectal Cancer Death. JAMA Netw Open. 2024;7(7):e2423671. PMID 39028667 — tags: [foundations-reviews, screening] — cited by: INDEX.md, OPEN-QUESTIONS.md, wiki/overview.md, wiki/screening-and-early-detection.md
• Gupta S, et al. Birth Cohort Colorectal Cancer (CRC): Implications for Research and Practice. Clin Gastroenterol Hepatol. 2024;22(3):455-469.e7. PMID 38081492 — tags: [foundations-reviews] — cited by: wiki/epidemiology-and-burden.md, wiki/overview.md
• Verheij FS, et al. Long-Term Results of Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy: The Randomized Phase II OPRA Trial. J Clin Oncol. 2024;42(5):500-506. PMID 37883738 — tags: [foundations-reviews, randomized-trial] — cited by: OPEN-QUESTIONS.md, literature/notes/verheij-2024-opra.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, literature/statistics/STATISTICS.md, wiki/clinical-trials-landscape.md, wiki/guidelines.md, wiki/localized-rectal-cancer.md, wiki/overview.md
• Wooldrage K, et al. Long-term effects of once-only flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: 21-year follow-up of the UK Flexible Sigmoidoscopy Screening randomised controlled trial. Lancet Gastroenterol Hepatol. 2024;9(9):811-824. PMID 39038482 — tags: [foundations-reviews, randomized-trial, screening] — cited by: wiki/guidelines.md, wiki/overview.md, wiki/screening-and-early-detection.md
• Kopetz S, et al. Encorafenib, cetuximab and chemotherapy in BRAF-mutant colorectal cancer: a randomized phase 3 trial. Nat Med. 2025;31(3):901-908. PMID 39863775 — tags: [foundations-reviews, randomized-trial] — cited by: wiki/clinical-trials-landscape.md, wiki/guidelines.md, wiki/metastatic-systemic-therapy.md, wiki/overview.md, wiki/precision-oncology.md

Pathology, staging and diagnostic workup

• Jass JR, et al. Recommendations for the reporting of surgically resected specimens of colorectal carcinoma. Hum Pathol. 2007;38(4):537-545. PMID 17270246 — tags: [pathology-staging-diagnostic-workup] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md, wiki/pathology-staging-and-diagnostic-workup.md
• Pisano M, et al. 2017 WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation. World J Emerg Surg. 2018;13:36. PMID 30123315 — tags: [pathology-staging-diagnostic-workup, guideline] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md, wiki/pathology-staging-and-diagnostic-workup.md, wiki/red-flags-and-safety-concerns.md
• Shinkins B, et al. Serum carcinoembryonic antigen trends for diagnosing colorectal cancer recurrence in the FACS randomized clinical trial. Br J Surg. 2018;105(6):658-662. PMID 29579327 — tags: [pathology-staging-diagnostic-workup, randomized-trial] — cited by: wiki/biomarkers-and-liquid-biopsy.md, wiki/pathology-staging-and-diagnostic-workup.md, wiki/survivorship-and-late-effects.md
• Dawson H, et al. Validation of the International Tumor Budding Consensus Conference 2016 recommendations on tumor budding in stage I-IV colorectal cancer. Hum Pathol. 2019;85:145-151. PMID 30428391 — tags: [pathology-staging-diagnostic-workup] — cited by: wiki/pathology-staging-and-diagnostic-workup.md
• Ried T, et al. The landscape of genomic copy number alterations in colorectal cancer and their consequences on gene expression levels and disease outcome. Mol Aspects Med. 2019;69:48-61. PMID 31365882 — tags: [pathology-staging-diagnostic-workup] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md, wiki/pathology-staging-and-diagnostic-workup.md
• Huang A, et al. Mucinous adenocarcinoma: A unique clinicopathological subtype in colorectal cancer. World J Gastrointest Surg. 2021;13(12):1567-1583. PMID 35070064 — tags: [pathology-staging-diagnostic-workup] — cited by: wiki/pathology-staging-and-diagnostic-workup.md
• Liemburg GB, et al. Diagnostic accuracy of follow-up tests for detecting colorectal cancer recurrences in primary care: A systematic review and meta-analysis. Eur J Cancer Care (Engl). 2021;30(5):e13432. PMID 33704843 — tags: [pathology-staging-diagnostic-workup, meta-analysis, systematic-review] — cited by: wiki/biomarkers-and-liquid-biopsy.md, wiki/pathology-staging-and-diagnostic-workup.md, wiki/red-flags-and-safety-concerns.md, wiki/survivorship-and-late-effects.md
• Pearlman R, et al. Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention Initiative. JCO Precis Oncol. 2021;5. PMID 34250417 — tags: [pathology-staging-diagnostic-workup, screening] — cited by: literature/statistics/STATISTICS.md, wiki/hereditary-syndromes-and-genetics.md, wiki/pathology-staging-and-diagnostic-workup.md
• Studer L, et al. Taking tumour budding to the next frontier - a post International Tumour Budding Consensus Conference (ITBCC) 2016 review. Histopathology. 2021;78(4):476-484. PMID 33001500 — tags: [pathology-staging-diagnostic-workup] — cited by: wiki/pathology-staging-and-diagnostic-workup.md
• Emile SH, et al. Assessment of mesorectal fascia status in MRI compared with circumferential resection margin after total mesorectal excision and predictors of involved margins. Surgery. 2022;172(4):1085-1092. PMID 35970606 — tags: [pathology-staging-diagnostic-workup] — cited by: wiki/pathology-staging-and-diagnostic-workup.md
• Jiang W, et al. Universal germline testing among patients with colorectal cancer: clinical actionability and optimised panel. J Med Genet. 2022;59(4):370-376. PMID 33563768 — tags: [pathology-staging-diagnostic-workup] — cited by: wiki/hereditary-syndromes-and-genetics.md, wiki/pathology-staging-and-diagnostic-workup.md
• Khaliq AM, et al. Refining colorectal cancer classification and clinical stratification through a single-cell atlas. Genome Biol. 2022;23(1):113. PMID 35538548 — tags: [pathology-staging-diagnostic-workup] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md, wiki/pathology-staging-and-diagnostic-workup.md
• Lambregts DMJ, et al. Current controversies in TNM for the radiological staging of rectal cancer and how to deal with them: results of a global online survey and multidisciplinary expert consensus. Eur Radiol. 2022;32(7):4991-5003. PMID 35254485 — tags: [pathology-staging-diagnostic-workup] — cited by: wiki/localized-rectal-cancer.md, wiki/pathology-staging-and-diagnostic-workup.md
• Uson PLS, et al. Germline Cancer Susceptibility Gene Testing in Unselected Patients With Colorectal Adenocarcinoma: A Multicenter Prospective Study. Clin Gastroenterol Hepatol. 2022;20(3):e508-e528. PMID 33857637 — tags: [pathology-staging-diagnostic-workup] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, literature/statistics/STATISTICS.md, wiki/epidemiology-and-burden.md, wiki/guidelines.md, wiki/hereditary-syndromes-and-genetics.md, wiki/pathology-staging-and-diagnostic-workup.md, wiki/patient-experience-and-advocacy.md
• Cornish AJ, et al. The genomic landscape of 2,023 colorectal cancers. Nature. 2024;633(8028):127-136. PMID 39112709 — tags: [pathology-staging-diagnostic-workup] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md, wiki/pathology-staging-and-diagnostic-workup.md
• Dunne PD, Arends MJ. Molecular pathological classification of colorectal cancer-an update. Virchows Arch. 2024;484(2):273-285. PMID 38319359 — tags: [pathology-staging-diagnostic-workup] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md, wiki/pathology-staging-and-diagnostic-workup.md
• Williams H, et al. MRI Predicts Residual Disease and Outcomes in Watch-and-Wait Patients with Rectal Cancer. Radiology. 2024;312(3):e232748. PMID 39225603 — tags: [pathology-staging-diagnostic-workup] — cited by: wiki/localized-rectal-cancer.md, wiki/pathology-staging-and-diagnostic-workup.md

Epidemiology and burden

• Huang JL, et al. Approaching the Hard-to-Reach in Organized Colorectal Cancer Screening: an Overview of Individual, Provider and System Level Coping Strategies. AIMS Public Health. 2017;4(3):289-300. PMID 29546218 — tags: [epidemiology-burden, screening] — cited by: wiki/epidemiology-and-burden.md, wiki/screening-and-early-detection.md
• Liang PS, et al. Temporal Trends in Geographic and Sociodemographic Disparities in Colorectal Cancer Among Medicare Patients, 1973-2010. J Rural Health. 2017;33(4):361-370. PMID 27578387 — tags: [epidemiology-burden] — cited by: wiki/epidemiology-and-burden.md
• Zahnd WE, Fogleman AJ, Jenkins WD. Rural-Urban Disparities in Stage of Diagnosis Among Cancers With Preventive Opportunities. Am J Prev Med. 2018;54(5):688-698. PMID 29550163 — tags: [epidemiology-burden] — cited by: wiki/epidemiology-and-burden.md
• Mauri G, et al. Early-onset colorectal cancer in young individuals. Mol Oncol. 2019;13(2):109-131. PMID 30520562 — tags: [epidemiology-burden] — cited by: wiki/epidemiology-and-burden.md
• Moss JL, et al. Geographic disparities in cancer screening and fatalism among a nationally representative sample of US adults. J Epidemiol Community Health. 2019;73(12):1128-1135. PMID 31615890 — tags: [epidemiology-burden, screening] — cited by: wiki/epidemiology-and-burden.md
• Patel A, et al. The role of socioeconomic disparity in colorectal cancer stage at presentation. Updates Surg. 2019;71(3):523-531. PMID 30788664 — tags: [epidemiology-burden] — cited by: wiki/epidemiology-and-burden.md
• Burn J, et al. Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial. Lancet. 2020;395(10240):1855-1863. PMID 32534647 — tags: [epidemiology-burden, randomized-trial] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md, wiki/epidemiology-and-burden.md, wiki/hereditary-syndromes-and-genetics.md
• Global Burden of Disease 2019 Cancer Collaboration, et al. Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019. JAMA Oncol. 2022;8(3):420-444. PMID 34967848 — tags: [epidemiology-burden] — cited by: INDEX.md, literature/statistics/STATISTICS.md, wiki/epidemiology-and-burden.md
• Iezzoni LI. Cancer detection, diagnosis, and treatment for adults with disabilities. Lancet Oncol. 2022;23(4):e164-e173. PMID 35358465 — tags: [epidemiology-burden] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/epidemiology-and-burden.md, wiki/patient-experience-and-advocacy.md
• Ogawa K, et al. Evaluation of clinical outcomes with propensity-score matching for colorectal cancer presenting as an oncologic emergency. Ann Gastroenterol Surg. 2022;6(4):523-530. PMID 35847445 — tags: [epidemiology-burden] — cited by: wiki/epidemiology-and-burden.md, wiki/red-flags-and-safety-concerns.md
• Vives N, et al. Short-term impact of the COVID-19 pandemic on a population-based screening program for colorectal cancer in Catalonia (Spain). Prev Med. 2022;155:106929. PMID 34954239 — tags: [epidemiology-burden, screening] — cited by: wiki/epidemiology-and-burden.md
• Xia C, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J (Engl). 2022;135(5):584-590. PMID 35143424 — tags: [epidemiology-burden] — cited by: wiki/epidemiology-and-burden.md
• Cubiella J, et al. Impact of the COVID-19 Pandemic on the Diagnosis of Colorectal Cancer within a Population-Based Organized Screening Program. Cancers (Basel). 2023;15(19). PMID 37835547 — tags: [epidemiology-burden, screening] — cited by: wiki/epidemiology-and-burden.md
• Saraiva MR, Rosa I, Claro I. Early-onset colorectal cancer: A review of current knowledge. World J Gastroenterol. 2023;29(8):1289-1303. PMID 36925459 — tags: [epidemiology-burden] — cited by: wiki/epidemiology-and-burden.md
• Tobin EC, et al. The Intersection of Race and Rurality and its Effect on Colorectal Cancer Survival. Am Surg. 2023;89(7):3163-3170. PMID 36890731 — tags: [epidemiology-burden, survivorship] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/epidemiology-and-burden.md, wiki/patient-experience-and-advocacy.md
• Cao W, et al. Socioeconomic inequalities in cancer incidence and mortality: An analysis of GLOBOCAN 2022. Chin Med J (Engl). 2024;137(12):1407-1413. PMID 38616547 — tags: [epidemiology-burden] — cited by: wiki/epidemiology-and-burden.md
• Islami F, et al. American Cancer Society's report on the status of cancer disparities in the United States, 2023. CA Cancer J Clin. 2024;74(2):136-166. PMID 37962495 — tags: [epidemiology-burden] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, literature/statistics/STATISTICS.md, wiki/epidemiology-and-burden.md, wiki/patient-experience-and-advocacy.md
• Coughlin SS, et al. The Influence of Poverty and Rurality on Colorectal Cancer Survival by Race/Ethnicity: An Analysis of SEER Data with a Census Tract-Level Measure of Persistent Poverty. Curr Oncol. 2025;32(5). PMID 40422507 — tags: [epidemiology-burden, survivorship] — cited by: wiki/epidemiology-and-burden.md

Carcinogenesis, precursors and screening biology

• Cottet V, et al. Long-term risk of colorectal cancer after adenoma removal: a population-based cohort study. Gut. 2012;61(8):1180-6. PMID 22110052 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Bettington M, et al. The serrated pathway to colorectal carcinoma: current concepts and challenges. Histopathology. 2013;62(3):367-86. PMID 23339363 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Knabe M, et al. Standardized long-term follow-up after endoscopic resection of large, nonpedunculated colorectal lesions: a prospective two-center study. Am J Gastroenterol. 2014;109(2):183-9. PMID 24343549 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Coleman HG, et al. Colorectal Cancer Risk Following Adenoma Removal: A Large Prospective Population-Based Cohort Study. Cancer Epidemiol Biomarkers Prev. 2015;24(9):1373-80. PMID 26082403 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Kahi CJ. How does the serrated polyp pathway alter CRC screening and surveillance? Dig Dis Sci. 2015;60(3):773-80. PMID 25556584 — tags: [carcinogenesis-precursors-screening-biology, screening] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Langner C. Serrated and non-serrated precursor lesions of colorectal cancer. Dig Dis. 2015;33(1):28-37. PMID 25531494 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Atkin W, et al. Adenoma surveillance and colorectal cancer incidence: a retrospective, multicentre, cohort study. Lancet Oncol. 2017;18(6):823-834. PMID 28457708 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md, wiki/guidelines.md
• Cisyk AL, et al. Characterizing Microsatellite Instability and Chromosome Instability in Interval Colorectal Cancers. Neoplasia. 2018;20(9):943-950. PMID 30121009 — tags: [carcinogenesis-precursors-screening-biology, msi] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md, wiki/molecular-subtypes-and-tumor-microenvironment.md
• Mouchli MA, et al. Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer. World J Gastroenterol. 2018;24(8):905-916. PMID 29491684 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Lindholm CR, Anderson JC, Srivastava A. The dark side of the colon: current issues surrounding the significance, prevalence, detection, diagnosis and management of serrated polyps. Curr Opin Gastroenterol. 2019;35(1):34-41. PMID 30407260 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Maida M, et al. Quality measures improving endoscopic screening of colorectal cancer: a review of the literature. Expert Rev Anticancer Ther. 2019;19(3):223-235. PMID 30614284 — tags: [carcinogenesis-precursors-screening-biology, screening] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• McCarthy AJ, Serra S, Chetty R. Traditional serrated adenoma: an overview of pathology and emphasis on molecular pathogenesis. BMJ Open Gastroenterol. 2019;6(1):e000317. PMID 31413858 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Kim JH, Kang GH. Evolving pathologic concepts of serrated lesions of the colorectum. J Pathol Transl Med. 2020;54(4):276-289. PMID 32580537 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Song M, et al. Risk of colorectal cancer incidence and mortality after polypectomy: a Swedish record-linkage study. Lancet Gastroenterol Hepatol. 2020;5(6):537-547. PMID 32192628 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Yang X, et al. Incidence and Mortality of Post-Polypectomy Colorectal Cancer in Patients with Low-Risk Adenomas: A Systematic Review and Meta-Analysis of Observational Studies. Dig Dis. 2023;41(2):206-216. PMID 35350026 — tags: [carcinogenesis-precursors-screening-biology, meta-analysis, systematic-review] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md
• Wang JD, et al. The histologic features, molecular features, detection and management of serrated polyps: a review. Front Oncol. 2024;14:1356250. PMID 38515581 — tags: [carcinogenesis-precursors-screening-biology] — cited by: wiki/adenoma-carcinoma-and-serrated-pathways.md

Molecular subtypes and tumor microenvironment

• Hagland HR, et al. Molecular pathways and cellular metabolism in colorectal cancer. Dig Surg. 2013;30(1):12-25. PMID 23595116 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Vilar E, Tabernero J. Molecular dissection of microsatellite instable colorectal cancer. Cancer Discov. 2013;3(5):502-11. PMID 23454900 — tags: [molecular-subtypes-tumor-microenvironment, msi] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Kudryavtseva AV, et al. Important molecular genetic markers of colorectal cancer. Oncotarget. 2016;7(33):53959-53983. PMID 27276710 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Fischer J, et al. Clinical implications of the genetics of sporadic colorectal cancer. ANZ J Surg. 2019;89(10):1224-1229. PMID 30919552 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Fontana E, et al. Context matters-consensus molecular subtypes of colorectal cancer as biomarkers for clinical trials. Ann Oncol. 2019;30(4):520-527. PMID 30796810 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Lenz HJ, et al. Impact of Consensus Molecular Subtype on Survival in Patients With Metastatic Colorectal Cancer: Results From CALGB/SWOG 80405 (Alliance). J Clin Oncol. 2019;37(22):1876-1885. PMID 31042420 — tags: [molecular-subtypes-tumor-microenvironment, survivorship] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Serebriiskii IG, et al. Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients. Nat Commun. 2019;10(1):3722. PMID 31427573 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Rebersek M. Consensus molecular subtypes (CMS) in metastatic colorectal cancer - personalized medicine decision. Radiol Oncol. 2020;54(3):272-277. PMID 32463385 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Valenzuela G, et al. Consensus molecular subtypes of colorectal cancer in clinical practice: A translational approach. World J Clin Oncol. 2021;12(11):1000-1008. PMID 34909395 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Stahler A, et al. Consensus Molecular Subtypes as Biomarkers of Fluorouracil and Folinic Acid Maintenance Therapy With or Without Panitumumab in RAS Wild-Type Metastatic Colorectal Cancer (PanaMa, AIO KRK 0212). J Clin Oncol. 2023;41(16):2975-2987. PMID 37018649 — tags: [molecular-subtypes-tumor-microenvironment, randomized-trial] — cited by: OPEN-QUESTIONS.md, wiki/molecular-subtypes-and-tumor-microenvironment.md
• Farin HF, et al. Colorectal Cancer Organoid-Stroma Biobank Allows Subtype-Specific Assessment of Individualized Therapy Responses. Cancer Discov. 2023;13(10):2192-2211. PMID 37489084 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Heiser CN, et al. Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors. Cell. 2023;186(25):5620-5637.e16. PMID 38065082 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Chowdhury S, et al. Consensus molecular subtyping of metastatic colorectal cancer expands biomarker-directed therapeutic benefit for patients with CMS1 and CMS2 tumors. Br J Cancer. 2024;131(8):1328-1339. PMID 39227409 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Feliu J, et al. Functional proteomics of colon cancer Consensus Molecular Subtypes. Br J Cancer. 2024;130(10):1670-1678. PMID 38486123 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• Valdeolivas A, et al. Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics. NPJ Precis Oncol. 2024;8(1):10. PMID 38200223 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md
• de Back TR, et al. A consensus molecular subtypes classification strategy for clinical colorectal cancer tissues. Life Sci Alliance. 2024;7(8). PMID 38782602 — tags: [molecular-subtypes-tumor-microenvironment] — cited by: wiki/molecular-subtypes-and-tumor-microenvironment.md

Hereditary syndromes and genetics

• Lynch HT, Smyrk T, Lynch J. An update of HNPCC (Lynch syndrome). Cancer Genet Cytogenet. 1997;93(1):84-99. PMID 9062584 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Lynch HT, de la Chapelle A. Genetic susceptibility to non-polyposis colorectal cancer. J Med Genet. 1999;36(11):801-18. PMID 10544223 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Dunlop MG, British Society for Gastroenterology, Association of Coloproctology for Great Britain and Ireland. Guidance on gastrointestinal surveillance for hereditary non-polyposis colorectal cancer, familial adenomatous polypolis, juvenile polyposis, and Peutz-Jeghers syndrome. Gut. 2002;51 Suppl 5(Suppl 5):V21-7. PMID 12221036 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Knudsen AL, Bisgaard ML, Bülow S. Attenuated familial adenomatous polyposis (AFAP). A review of the literature. Fam Cancer. 2003;2(1):43-55. PMID 14574166 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Galiatsatos P, Foulkes WD. Familial adenomatous polyposis. Am J Gastroenterol. 2006;101(2):385-98. PMID 16454848 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Half E, Bercovich D, Rozen P. Familial adenomatous polyposis. Orphanet J Rare Dis. 2009;4:22. PMID 19822006 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Aretz S. The differential diagnosis and surveillance of hereditary gastrointestinal polyposis syndromes. Dtsch Arztebl Int. 2010;107(10):163-73. PMID 20358032 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Tudyka VN, Clark SK. Surgical treatment in familial adenomatous polyposis. Ann Gastroenterol. 2012;25(3):201-206. PMID 24714154 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Aihara H, Kumar N, Thompson CC. Diagnosis, surveillance, and treatment strategies for familial adenomatous polyposis: rationale and update. Eur J Gastroenterol Hepatol. 2014;26(3):255-62. PMID 24161962 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Syngal S, et al. ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol. 2015;110(2):223-62; quiz 263. PMID 25645574 — tags: [hereditary-syndromes-genetics, guideline] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md, wiki/hereditary-syndromes-and-genetics.md
• Møller P, et al. Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database. Gut. 2017;66(3):464-472. PMID 26657901 — tags: [hereditary-syndromes-genetics, survivorship] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Buchanan DD, et al. Risk of colorectal cancer for carriers of a germ-line mutation in POLE or POLD1. Genet Med. 2018;20(8):890-895. PMID 29120461 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Monahan KJ, et al. Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG). Gut. 2020;69(3):411-444. PMID 31780574 — tags: [hereditary-syndromes-genetics, guideline] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md, wiki/hereditary-syndromes-and-genetics.md
• Mur P, et al. Role of POLE and POLD1 in familial cancer. Genet Med. 2020;22(12):2089-2100. PMID 32792570 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Seppälä TT, et al. Prospective observational data informs understanding and future management of Lynch syndrome: insights from the Prospective Lynch Syndrome Database (PLSD). Fam Cancer. 2021;20(1):35-39. PMID 32507935 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Mathers JC, et al. Cancer Prevention with Resistant Starch in Lynch Syndrome Patients in the CAPP2-Randomized Placebo Controlled Trial: Planned 10-Year Follow-up. Cancer Prev Res (Phila). 2022;15(9):623-634. PMID 35878732 — tags: [hereditary-syndromes-genetics, randomized-trial] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Dominguez-Valentin M, et al. Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database. EClinicalMedicine. 2023;58:101909. PMID 37181409 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Mur P, et al. Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1. Genome Med. 2023;15(1):85. PMID 37848928 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md, wiki/precision-oncology.md
• Peltomäki P, et al. Lynch Syndrome Genetics and Clinical Implications. Gastroenterology. 2023;164(5):783-799. PMID 36706841 — tags: [hereditary-syndromes-genetics] — cited by: wiki/hereditary-syndromes-and-genetics.md
• Ehrencrona H, et al. Direct letters to relatives at risk of hereditary cancer-a randomised trial on healthcare-assisted versus family-mediated risk disclosure. Eur J Hum Genet. 2025;33(10):1359-1367. PMID 40745491 — tags: [hereditary-syndromes-genetics, randomized-trial] — cited by: OPEN-QUESTIONS.md, wiki/hereditary-syndromes-and-genetics.md

Screening and early detection

• Honein-AbouHaidar GN, et al. Systematic Review and Meta-study Synthesis of Qualitative Studies Evaluating Facilitators and Barriers to Participation in Colorectal Cancer Screening. Cancer Epidemiol Biomarkers Prev. 2016;25(6):907-17. PMID 27197277 — tags: [screening-early-detection, systematic-review, screening] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/screening-and-early-detection.md
• Wieszczy P, Regula J, Kaminski MF. Adenoma detection rate and risk of colorectal cancer. Best Pract Res Clin Gastroenterol. 2017;31(4):441-446. PMID 28842054 — tags: [screening-early-detection] — cited by: wiki/screening-and-early-detection.md
• Holme Ø, et al. Long-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men: A Randomized Trial. Ann Intern Med. 2018;168(11):775-782. PMID 29710125 — tags: [screening-early-detection, randomized-trial, screening] — cited by: wiki/screening-and-early-detection.md
• Wolf AMD, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA Cancer J Clin. 2018;68(4):250-281. PMID 29846947 — tags: [screening-early-detection, guideline, screening] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md, wiki/screening-and-early-detection.md
• Miller EA, et al. Effect of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: long-term follow-up of the randomised US PLCO cancer screening trial. Lancet Gastroenterol Hepatol. 2019;4(2):101-110. PMID 30502933 — tags: [screening-early-detection, randomized-trial, screening] — cited by: wiki/screening-and-early-detection.md
• Chin YH, et al. Evolving perspectives on stool testing for colorectal cancer: a qualitative systematic review. Eur J Cancer Prev. 2020;29(5):416-423. PMID 32740167 — tags: [screening-early-detection, systematic-review] — cited by: literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/screening-and-early-detection.md
• Lim KT, et al. Barriers and facilitators towards colonoscopy: a qualitative systematic review. Eur J Cancer Prev. 2021;30(3):232-238. PMID 32694277 — tags: [screening-early-detection, systematic-review] — cited by: literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/screening-and-early-detection.md
• Waldmann E, et al. Association of Adenoma Detection Rate and Adenoma Characteristics With Colorectal Cancer Mortality After Screening Colonoscopy. Clin Gastroenterol Hepatol. 2021;19(9):1890-1898. PMID 33878471 — tags: [screening-early-detection, screening] — cited by: wiki/screening-and-early-detection.md
• Senore C, et al. Long-Term Follow-up of the Italian Flexible Sigmoidoscopy Screening Trial. Ann Intern Med. 2022;175(1):36-45. PMID 34748376 — tags: [screening-early-detection, screening] — cited by: wiki/screening-and-early-detection.md
• Harnan S, et al. Faecal immunochemical tests for patients with symptoms suggestive of colorectal cancer: An updated systematic review and multiple-threshold meta-analysis of diagnostic test accuracy studies. Colorectal Dis. 2024;27(1). PMID 39690130 — tags: [screening-early-detection, meta-analysis, systematic-review] — cited by: wiki/screening-and-early-detection.md
• Imperiale TF, et al. Next-Generation Multitarget Stool DNA Test for Colorectal Cancer Screening. N Engl J Med. 2024;390(11):984-993. PMID 38477986 — tags: [screening-early-detection, screening] — cited by: literature/statistics/STATISTICS.md, wiki/screening-and-early-detection.md
• Castells A, et al. Effect of invitation to colonoscopy versus faecal immunochemical test screening on colorectal cancer mortality (COLONPREV): a pragmatic, randomised, controlled, non-inferiority trial. Lancet. 2025;405(10486):1231-1239. PMID 40158525 — tags: [screening-early-detection, randomized-trial, screening] — cited by: wiki/screening-and-early-detection.md
• Shaukat A, et al. Clinical Validation of a Circulating Tumor DNA-Based Blood Test to Screen for Colorectal Cancer. JAMA. 2025;334(1):56-63. PMID 40455622 — tags: [screening-early-detection, ctdna, screening] — cited by: wiki/screening-and-early-detection.md
• Chaparro S, et al. Disparities in colonoscopy adherence and neoplasia detection after positive fecal immunochemical test: a retrospective matched cohort study. Cancer Causes Control. 2026;37(9). PMID 42517977 — tags: [screening-early-detection] — cited by: wiki/screening-and-early-detection.md
• Kaminski MF, et al. Long-term effects of colonoscopy screening on colorectal cancer incidence and mortality: a multicountry, population-based randomised controlled trial. Lancet. 2026;407(10541):1787-1795. PMID 42102826 — tags: [screening-early-detection, randomized-trial, screening] — cited by: wiki/screening-and-early-detection.md

Localized colon cancer

• Quasar Collaborative Group, et al. Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet. 2007;370(9604):2020-9. PMID 18083404 — tags: [localized-colon-cancer, randomized-trial] — cited by: literature/statistics/STATISTICS.md, wiki/guidelines.md, wiki/localized-colon-cancer.md
• Kontovounisios C, et al. Complete mesocolic excision in colorectal cancer: a systematic review. Colorectal Dis. 2015;17(1):7-16. PMID 25283236 — tags: [localized-colon-cancer, systematic-review] — cited by: wiki/localized-colon-cancer.md
• Pectasides D, et al. Randomized phase III clinical trial comparing the combination of capecitabine and oxaliplatin (CAPOX) with the combination of 5-fluorouracil, leucovorin and oxaliplatin (modified FOLFOX6) as adjuvant therapy in patients with operated high-risk stage II or stage III colorectal cancer. BMC Cancer. 2015;15:384. PMID 25956750 — tags: [localized-colon-cancer, randomized-trial] — cited by: wiki/localized-colon-cancer.md
• Emmanuel A, Haji A. Complete mesocolic excision and extended (D3) lymphadenectomy for colonic cancer: is it worth that extra effort? A review of the literature. Int J Colorectal Dis. 2016;31(4):797-804. PMID 26833471 — tags: [localized-colon-cancer] — cited by: wiki/localized-colon-cancer.md
• Kahi CJ, et al. Colonoscopy Surveillance After Colorectal Cancer Resection: Recommendations of the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2016;150(3):758-768.e11. PMID 26892199 — tags: [localized-colon-cancer] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md, wiki/localized-colon-cancer.md, wiki/survivorship-and-late-effects.md
• Lonardi S, et al. Phase III trial comparing 3-6 months of adjuvant FOLFOX4/XELOX in stage II-III colon cancer: safety and compliance in the TOSCA trial. Ann Oncol. 2016;27(11):2074-2081. PMID 27573560 — tags: [localized-colon-cancer] — cited by: wiki/localized-colon-cancer.md
• André T, et al. Three Versus 6 Months of Oxaliplatin-Based Adjuvant Chemotherapy for Patients With Stage III Colon Cancer: Disease-Free Survival Results From a Randomized, Open-Label, International Duration Evaluation of Adjuvant (IDEA) France, Phase III Trial. J Clin Oncol. 2018;36(15):1469-1477. PMID 29620995 — tags: [localized-colon-cancer, randomized-trial, survivorship] — cited by: wiki/localized-colon-cancer.md
• Henricks LM, et al. DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis. Lancet Oncol. 2018;19(11):1459-1467. PMID 30348537 — tags: [localized-colon-cancer] — cited by: wiki/localized-colon-cancer.md, wiki/red-flags-and-safety-concerns.md
• Lieu C, et al. Duration of Oxaliplatin-Containing Adjuvant Therapy for Stage III Colon Cancer: ASCO Clinical Practice Guideline. J Clin Oncol. 2019;37(16):1436-1447. PMID 30986117 — tags: [localized-colon-cancer, guideline] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md, wiki/localized-colon-cancer.md
• Souglakos J, et al. Three- versus six-month adjuvant FOLFOX or CAPOX for high-risk stage II and stage III colon cancer patients: the efficacy results of Hellenic Oncology Research Group (HORG) participation to the International Duration Evaluation of Adjuvant Chemotherapy (IDEA) project. Ann Oncol. 2019;30(8):1304-1310. PMID 31228203 — tags: [localized-colon-cancer] — cited by: wiki/localized-colon-cancer.md
• Anania G, et al. Right hemicolectomy with complete mesocolic excision is safe, leads to an increased lymph node yield and to increased survival: results of a systematic review and meta-analysis. Tech Coloproctol. 2021;25(10):1099-1113. PMID 34120270 — tags: [localized-colon-cancer, meta-analysis, systematic-review] — cited by: wiki/localized-colon-cancer.md
• Taniguchi H, et al. CIRCULATE-Japan: Circulating tumor DNA-guided adaptive platform trials to refine adjuvant therapy for colorectal cancer. Cancer Sci. 2021;112(7):2915-2920. PMID 33931919 — tags: [localized-colon-cancer, ctdna] — cited by: wiki/biomarkers-and-liquid-biopsy.md, wiki/clinical-trials-landscape.md, wiki/localized-colon-cancer.md
• Baxter NN, et al. Adjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update. J Clin Oncol. 2022;40(8):892-910. PMID 34936379 — tags: [localized-colon-cancer, guideline] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md, wiki/localized-colon-cancer.md
• Giani A, et al. Mid-term oncological outcomes after complete versus conventional mesocolic excision for right-sided colon cancer: a propensity score matching analysis. Surg Endosc. 2022;36(9):6489-6496. PMID 35028735 — tags: [localized-colon-cancer] — cited by: wiki/localized-colon-cancer.md
• Konishi T, You YN. Complete Mesocolic Excision and Extent of Lymphadenectomy for the Treatment of Colon Cancer. Surg Oncol Clin N Am. 2022;31(2):293-306. PMID 35351279 — tags: [localized-colon-cancer] — cited by: wiki/localized-colon-cancer.md
• Xu J, et al. Complete mesocolic excision versus standard resection for colon cancer: a systematic review and meta-analysis of perioperative safety and an evaluation of the use of a robotic approach. Tech Coloproctol. 2023;27(11):995-1005. PMID 37414915 — tags: [localized-colon-cancer, meta-analysis, systematic-review] — cited by: wiki/localized-colon-cancer.md
• Franken IA, et al. Survival and patient-reported outcomes of real-world high-risk stage II and stage III colon cancer patients after reduction of adjuvant CAPOX duration from 6 to 3 months. Eur J Cancer. 2024;208:114207. PMID 39024724 — tags: [localized-colon-cancer, survivorship] — cited by: wiki/localized-colon-cancer.md
• Nakamura Y, et al. ctDNA-based molecular residual disease and survival in resectable colorectal cancer. Nat Med. 2024;30(11):3272-3283. PMID 39284954 — tags: [localized-colon-cancer, survivorship] — cited by: wiki/biomarkers-and-liquid-biopsy.md, wiki/localized-colon-cancer.md
• Noronha MM, et al. Neoadjuvant chemotherapy for colon cancer: A systematic review and meta-analysis of randomized controlled trials. Eur J Cancer. 2025;222:115476. PMID 40306117 — tags: [localized-colon-cancer, randomized-trial, meta-analysis] — cited by: wiki/localized-colon-cancer.md
• Tie J, et al. Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: 5-year outcomes of the randomized DYNAMIC trial. Nat Med. 2025;31(5):1509-1518. PMID 40055522 — tags: [localized-colon-cancer, randomized-trial, ctdna] — cited by: wiki/biomarkers-and-liquid-biopsy.md, wiki/clinical-trials-landscape.md, wiki/localized-colon-cancer.md
• Tie J, et al. Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial. Nat Med. 2025;31(12):4291-4300. PMID 41115959 — tags: [localized-colon-cancer, randomized-trial, ctdna] — cited by: wiki/biomarkers-and-liquid-biopsy.md, wiki/clinical-trials-landscape.md, wiki/localized-colon-cancer.md

Localized rectal cancer

• van Gijn W, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial. Lancet Oncol. 2011;12(6):575-82. PMID 21596621 — tags: [localized-rectal-cancer, randomized-trial] — cited by: wiki/localized-rectal-cancer.md
• Bondeven P. Cancer of the upper rectum. Dan Med J. 2016;63(10). PMID 27697137 — tags: [localized-rectal-cancer] — cited by: wiki/localized-rectal-cancer.md
• Bernier L, et al. Watch-and-Wait as a Therapeutic Strategy in Rectal Cancer. Curr Colorectal Cancer Rep. 2018;14(2):37-55. PMID 29576755 — tags: [localized-rectal-cancer] — cited by: wiki/localized-rectal-cancer.md
• Feeney G, et al. Neoadjuvant radiotherapy for rectal cancer management. World J Gastroenterol. 2019;25(33):4850-4869. PMID 31543678 — tags: [localized-rectal-cancer] — cited by: wiki/localized-rectal-cancer.md
• Keane C, et al. International Consensus Definition of Low Anterior Resection Syndrome. Dis Colon Rectum. 2020;63(3):274-284. PMID 32032141 — tags: [localized-rectal-cancer] — cited by: wiki/localized-rectal-cancer.md, wiki/survivorship-and-late-effects.md
• Conroy T, et al. Neoadjuvant chemotherapy with FOLFIRINOX and preoperative chemoradiotherapy for patients with locally advanced rectal cancer (UNICANCER-PRODIGE 23): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2021;22(5):702-715. PMID 33862000 — tags: [localized-rectal-cancer, randomized-trial] — cited by: literature/statistics/STATISTICS.md, wiki/localized-rectal-cancer.md
• Yuval JB, Garcia-Aguilar J. Watch-and-wait Management for Rectal Cancer After Clinical Complete Response to Neoadjuvant Therapy. Adv Surg. 2021;55:89-107. PMID 34389102 — tags: [localized-rectal-cancer] — cited by: wiki/localized-rectal-cancer.md, wiki/red-flags-and-safety-concerns.md
• Cercek A, et al. PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer. N Engl J Med. 2022;386(25):2363-2376. PMID 35660797 — tags: [localized-rectal-cancer] — cited by: literature/statistics/STATISTICS.md, wiki/clinical-trials-landscape.md, wiki/localized-rectal-cancer.md
• Fokas E, et al. Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial. JAMA Oncol. 2022;8(1):e215445. PMID 34792531 — tags: [localized-rectal-cancer, randomized-trial] — cited by: wiki/localized-rectal-cancer.md
• Jin J, et al. Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR). J Clin Oncol. 2022;40(15):1681-1692. PMID 35263150 — tags: [localized-rectal-cancer, randomized-trial] — cited by: wiki/localized-rectal-cancer.md
• Basch E, et al. Patient-Reported Outcomes During and After Treatment for Locally Advanced Rectal Cancer in the PROSPECT Trial (Alliance N1048). J Clin Oncol. 2023;41(21):3724-3734. PMID 37270691 — tags: [localized-rectal-cancer] — cited by: wiki/localized-rectal-cancer.md
• Custers PA, et al. Long-term Quality of Life and Functional Outcome of Patients With Rectal Cancer Following a Watch-and-Wait Approach. JAMA Surg. 2023;158(5):e230146. PMID 36988922 — tags: [localized-rectal-cancer] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/localized-rectal-cancer.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Schrag D, et al. Preoperative Treatment of Locally Advanced Rectal Cancer. N Engl J Med. 2023;389(4):322-334. PMID 37272534 — tags: [localized-rectal-cancer] — cited by: literature/statistics/STATISTICS.md, wiki/guidelines.md, wiki/localized-rectal-cancer.md
• Bercz A, et al. Organ preservation after neoadjuvant long-course chemoradiotherapy versus short-course radiotherapy. Ann Oncol. 2024;35(11):1003-1014. PMID 39266364 — tags: [localized-rectal-cancer] — cited by: wiki/localized-rectal-cancer.md
• Thompson HM, et al. Organ Preservation and Survival by Clinical Response Grade in Patients With Rectal Cancer Treated With Total Neoadjuvant Therapy: A Secondary Analysis of the OPRA Randomized Clinical Trial. JAMA Netw Open. 2024;7(1):e2350903. PMID 38194231 — tags: [localized-rectal-cancer, randomized-trial, survivorship] — cited by: wiki/localized-rectal-cancer.md
• Cercek A, et al. Nonoperative Management of Mismatch Repair-Deficient Tumors. N Engl J Med. 2025;392(23):2297-2308. PMID 40293177 — tags: [localized-rectal-cancer] — cited by: wiki/clinical-trials-landscape.md, wiki/localized-rectal-cancer.md
• Fernandez LM, et al. Risks of Organ Preservation in Rectal Cancer: Data From Two International Registries on Rectal Cancer. J Clin Oncol. 2025;43(14):1663-1672. PMID 39467217 — tags: [localized-rectal-cancer] — cited by: wiki/localized-rectal-cancer.md

Metastatic systemic therapy

• Grothey A, et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013;381(9863):303-12. PMID 23177514 — tags: [metastatic-systemic-therapy, randomized-trial] — cited by: literature/statistics/STATISTICS.md, wiki/metastatic-systemic-therapy.md
• Carter NJ. Regorafenib: a review of its use in previously treated patients with progressive metastatic colorectal cancer. Drugs Aging. 2014;31(1):67-78. PMID 24276917 — tags: [metastatic-systemic-therapy] — cited by: wiki/metastatic-systemic-therapy.md
• Mayer RJ, et al. Randomized trial of TAS-102 for refractory metastatic colorectal cancer. N Engl J Med. 2015;372(20):1909-19. PMID 25970050 — tags: [metastatic-systemic-therapy, randomized-trial] — cited by: literature/statistics/STATISTICS.md, wiki/metastatic-systemic-therapy.md
• Simkens LH, et al. Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): a phase 3 randomised controlled trial of the Dutch Colorectal Cancer Group. Lancet. 2015;385(9980):1843-52. PMID 25862517 — tags: [metastatic-systemic-therapy, randomized-trial] — cited by: wiki/metastatic-systemic-therapy.md
• Stein A, et al. Effect of Application and Intensity of Bevacizumab-based Maintenance After Induction Chemotherapy With Bevacizumab for Metastatic Colorectal Cancer: A Meta-analysis. Clin Colorectal Cancer. 2016;15(2):e29-39. PMID 26781523 — tags: [metastatic-systemic-therapy, meta-analysis] — cited by: wiki/metastatic-systemic-therapy.md
• Goey KKH, et al. Maintenance treatment with capecitabine and bevacizumab versus observation in metastatic colorectal cancer: updated results and molecular subgroup analyses of the phase 3 CAIRO3 study. Ann Oncol. 2017;28(9):2128-2134. PMID 28911067 — tags: [metastatic-systemic-therapy] — cited by: wiki/metastatic-systemic-therapy.md
• Venook AP, et al. Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial. JAMA. 2017;317(23):2392-2401. PMID 28632865 — tags: [metastatic-systemic-therapy, randomized-trial, survivorship] — cited by: literature/statistics/STATISTICS.md, wiki/metastatic-systemic-therapy.md, wiki/precision-oncology.md
• Shui L, et al. Triplet Chemotherapy (FOLFOXIRI) Plus Bevacizumab Versus Doublet Chemotherapy (FOLFOX/FOLFIRI) Plus Bevacizumab in Conversion Therapy for Metastatic Colorectal Cancer: a Meta-Analysis. Cell Physiol Biochem. 2018;48(5):1870-1881. PMID 30092572 — tags: [metastatic-systemic-therapy, meta-analysis] — cited by: wiki/metastatic-systemic-therapy.md
• Hurwitz HI, et al. Phase II Randomized Trial of Sequential or Concurrent FOLFOXIRI-Bevacizumab Versus FOLFOX-Bevacizumab for Metastatic Colorectal Cancer (STEAM). Oncologist. 2019;24(7):921-932. PMID 30552157 — tags: [metastatic-systemic-therapy, randomized-trial] — cited by: wiki/metastatic-systemic-therapy.md
• Parseghian CM, et al. Anti-EGFR-resistant clones decay exponentially after progression: implications for anti-EGFR re-challenge. Ann Oncol. 2019;30(2):243-249. PMID 30462160 — tags: [metastatic-systemic-therapy] — cited by: literature/statistics/STATISTICS.md, wiki/biomarkers-and-liquid-biopsy.md, wiki/metastatic-systemic-therapy.md, wiki/precision-oncology.md
• Sunakawa Y, et al. RAS Mutations in Circulating Tumor DNA and Clinical Outcomes of Rechallenge Treatment With Anti-EGFR Antibodies in Patients With Metastatic Colorectal Cancer. JCO Precis Oncol. 2020;4:898-911. PMID 35050760 — tags: [metastatic-systemic-therapy, ctdna] — cited by: wiki/metastatic-systemic-therapy.md, wiki/precision-oncology.md
• Rossini D, et al. Treatments after progression to first-line FOLFOXIRI and bevacizumab in metastatic colorectal cancer: a pooled analysis of TRIBE and TRIBE2 studies by GONO. Br J Cancer. 2021;124(1):183-190. PMID 33024268 — tags: [metastatic-systemic-therapy] — cited by: wiki/metastatic-systemic-therapy.md
• Bond MJG, et al. First-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases (CAIRO5): an open-label, multicentre, randomised, controlled, phase 3 study from the Dutch Colorectal Cancer Group. Lancet Oncol. 2023;24(7):757-771. PMID 37329889 — tags: [metastatic-systemic-therapy, randomized-trial] — cited by: wiki/liver-and-lung-metastasis.md, wiki/metastatic-systemic-therapy.md
• Chitkara A, et al. Risks of hypertension and thromboembolism in patients receiving bevacizumab with chemotherapy for colorectal cancer: A systematic review and meta-analysis. Cancer Med. 2023;12(24):21579-21591. PMID 38069531 — tags: [metastatic-systemic-therapy, meta-analysis, systematic-review] — cited by: wiki/metastatic-systemic-therapy.md, wiki/red-flags-and-safety-concerns.md
• Dasari A, et al. Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study. Lancet. 2023;402(10395):41-53. PMID 37331369 — tags: [metastatic-systemic-therapy, randomized-trial] — cited by: literature/statistics/STATISTICS.md, wiki/metastatic-systemic-therapy.md
• Prager GW, et al. Trifluridine-Tipiracil and Bevacizumab in Refractory Metastatic Colorectal Cancer. N Engl J Med. 2023;388(18):1657-1667. PMID 37133585 — tags: [metastatic-systemic-therapy] — cited by: literature/statistics/STATISTICS.md, wiki/metastatic-systemic-therapy.md
• Andre T, et al. Nivolumab plus Ipilimumab in Microsatellite-Instability-High Metastatic Colorectal Cancer. N Engl J Med. 2024;391(21):2014-2026. PMID 39602630 — tags: [metastatic-systemic-therapy, msi] — cited by: wiki/clinical-trials-landscape.md, wiki/metastatic-systemic-therapy.md, wiki/precision-oncology.md
• André T, et al. Nivolumab plus ipilimumab versus nivolumab in microsatellite instability-high metastatic colorectal cancer (CheckMate 8HW): a randomised, open-label, phase 3 trial. Lancet. 2025;405(10476):383-395. PMID 39874977 — tags: [metastatic-systemic-therapy, randomized-trial, msi] — cited by: wiki/clinical-trials-landscape.md, wiki/guidelines.md, wiki/metastatic-systemic-therapy.md, wiki/precision-oncology.md, wiki/red-flags-and-safety-concerns.md
• Ciracì P, et al. Late-line options for patients with metastatic colorectal cancer: a review and evidence-based algorithm. Nat Rev Clin Oncol. 2025;22(1):28-45. PMID 39558030 — tags: [metastatic-systemic-therapy] — cited by: wiki/metastatic-systemic-therapy.md

Precision oncology

• Sartore-Bianchi A, et al. Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial. Lancet Oncol. 2016;17(6):738-746. PMID 27108243 — tags: [precision-oncology] — cited by: wiki/precision-oncology.md
• Parseghian CM, et al. Mechanisms of Innate and Acquired Resistance to Anti-EGFR Therapy: A Review of Current Knowledge with a Focus on Rechallenge Therapies. Clin Cancer Res. 2019;25(23):6899-6908. PMID 31263029 — tags: [precision-oncology] — cited by: wiki/precision-oncology.md
• Tabernero J, et al. Management of adverse events from the treatment of encorafenib plus cetuximab for patients with BRAF V600E-mutant metastatic colorectal cancer: insights from the BEACON CRC study. ESMO Open. 2021;6(6):100328. PMID 34896698 — tags: [precision-oncology] — cited by: wiki/precision-oncology.md
• Sartore-Bianchi A, et al. Application of histology-agnostic treatments in metastatic colorectal cancer. Dig Liver Dis. 2022;54(10):1291-1303. PMID 35701319 — tags: [precision-oncology] — cited by: wiki/precision-oncology.md
• Le DT, et al. Pembrolizumab for previously treated, microsatellite instability-high/mismatch repair-deficient advanced colorectal cancer: final analysis of KEYNOTE-164. Eur J Cancer. 2023;186:185-195. PMID 37141828 — tags: [precision-oncology, msi] — cited by: wiki/precision-oncology.md
• Morris VK, et al. Treatment of Metastatic Colorectal Cancer: ASCO Guideline. J Clin Oncol. 2023;41(3):678-700. PMID 36252154 — tags: [precision-oncology, guideline] — cited by: literature/guidelines/REGISTRY.md, wiki/biomarkers-and-liquid-biopsy.md, wiki/guidelines.md, wiki/precision-oncology.md
• Patelli G, et al. Circulating Tumor DNA to Drive Treatment in Metastatic Colorectal Cancer. Clin Cancer Res. 2023;29(22):4530-4539. PMID 37436743 — tags: [precision-oncology, ctdna] — cited by: wiki/biomarkers-and-liquid-biopsy.md, wiki/precision-oncology.md
• Raghav K, et al. Acquired Genomic Alterations on First-Line Chemotherapy With Cetuximab in Advanced Colorectal Cancer: Circulating Tumor DNA Analysis of the CALGB/SWOG-80405 Trial (Alliance). J Clin Oncol. 2023;41(3):472-478. PMID 36067452 — tags: [precision-oncology, ctdna] — cited by: wiki/biomarkers-and-liquid-biopsy.md, wiki/precision-oncology.md
• Silvertown JD, et al. Prevalence of NTRK Fusions in Canadian Solid Tumour Cancer Patients. Mol Diagn Ther. 2023;27(1):87-103. PMID 36194351 — tags: [precision-oncology] — cited by: wiki/precision-oncology.md
• Topham JT, et al. Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti-Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer. J Clin Oncol. 2023;41(3):485-496. PMID 36007218 — tags: [precision-oncology, ctdna] — cited by: wiki/biomarkers-and-liquid-biopsy.md, wiki/precision-oncology.md
• Kuboki Y, et al. Sotorasib with panitumumab in chemotherapy-refractory KRASG12C-mutated colorectal cancer: a phase 1b trial. Nat Med. 2024;30(1):265-270. PMID 38177853 — tags: [precision-oncology] — cited by: wiki/precision-oncology.md
• da Silva LFL, et al. Anti-EGFR Rechallenge in Metastatic Colorectal Cancer and the Role of ctDNA: A Systematic Review and Meta-analysis. J Gastrointest Cancer. 2024;56(1):28. PMID 39623250 — tags: [precision-oncology, meta-analysis, systematic-review] — cited by: wiki/precision-oncology.md

Liver and lung metastasis

• Nordlinger B, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008;371(9617):1007-16. PMID 18358928 — tags: [liver-lung-metastasis, randomized-trial] — cited by: literature/statistics/STATISTICS.md, wiki/liver-and-lung-metastasis.md
• Sorbye H, et al. Predictive factors for the benefit of perioperative FOLFOX for resectable liver metastasis in colorectal cancer patients (EORTC Intergroup Trial 40983). Ann Surg. 2012;255(3):534-9. PMID 22314329 — tags: [liver-lung-metastasis] — cited by: wiki/liver-and-lung-metastasis.md
• Jones RP, et al. Perioperative chemotherapy for resectable colorectal liver metastases: where now? Eur J Surg Oncol. 2013;39(8):807-11. PMID 23726258 — tags: [liver-lung-metastasis] — cited by: wiki/liver-and-lung-metastasis.md
• Tanis E, et al. Local recurrence rates after radiofrequency ablation or resection of colorectal liver metastases. Analysis of the European Organisation for Research and Treatment of Cancer #40004 and #40983. Eur J Cancer. 2014;50(5):912-9. PMID 24411080 — tags: [liver-lung-metastasis] — cited by: literature/statistics/STATISTICS.md, wiki/liver-and-lung-metastasis.md
• Treasure T, et al. Pulmonary metastasectomy: what is the practice and where is the evidence for effectiveness? Thorax. 2014;69(10):946-9. PMID 24415715 — tags: [liver-lung-metastasis] — cited by: wiki/liver-and-lung-metastasis.md
• Beppu T, et al. Perioperative chemotherapy and hepatic resection for resectable colorectal liver metastases. Hepatobiliary Surg Nutr. 2015;4(1):72-5. PMID 25713806 — tags: [liver-lung-metastasis] — cited by: wiki/liver-and-lung-metastasis.md
• Dueland S, et al. Chemotherapy or liver transplantation for nonresectable liver metastases from colorectal cancer? Ann Surg. 2015;261(5):956-60. PMID 24950280 — tags: [liver-lung-metastasis] — cited by: literature/statistics/STATISTICS.md, wiki/liver-and-lung-metastasis.md
• Nigri G, et al. Neoadjuvant chemotherapy for resectable colorectal liver metastases: what is the evidence? Results of a systematic review of comparative studies. Surgeon. 2015;13(2):83-90. PMID 25257725 — tags: [liver-lung-metastasis, systematic-review] — cited by: wiki/liver-and-lung-metastasis.md
• Padmanabhan C, Parikh A. Perioperative chemotherapy for resectable colorectal hepatic metastases-What does the EORTC 40983 trial update mean? Hepatobiliary Surg Nutr. 2015;4(1):80-3. PMID 25713808 — tags: [liver-lung-metastasis] — cited by: wiki/liver-and-lung-metastasis.md
• Tanis E, et al. Prognostic impact of immune response in resectable colorectal liver metastases treated by surgery alone or surgery with perioperative FOLFOX in the randomised EORTC study 40983. Eur J Cancer. 2015;51(17):2708-17. PMID 26342674 — tags: [liver-lung-metastasis, randomized-trial] — cited by: wiki/liver-and-lung-metastasis.md
• Torres OJ, et al. BRAZILIAN CONSENSUS FOR MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 3: CONTROVERSIES AND UNRESECTABLE METASTASES. Arq Bras Cir Dig. 2016;29(3):173-179. PMID 27759781 — tags: [liver-lung-metastasis] — cited by: wiki/liver-and-lung-metastasis.md
• Stewart CL, et al. Cytoreduction for colorectal metastases: liver, lung, peritoneum, lymph nodes, bone, brain. When does it palliate, prolong survival, and potentially cure? Curr Probl Surg. 2018;55(9):330-379. PMID 30526930 — tags: [liver-lung-metastasis, survivorship] — cited by: wiki/liver-and-lung-metastasis.md
• Simoneau E, D'Angelica M, Halazun KJ. Liver transplantation for colorectal liver metastasis. Curr Opin Organ Transplant. 2019;24(2):175-181. PMID 30839338 — tags: [liver-lung-metastasis] — cited by: wiki/liver-and-lung-metastasis.md
• Bolhuis K, et al. Conversion strategies with chemotherapy plus targeted agents for colorectal cancer liver-only metastases: A systematic review. Eur J Cancer. 2020;141:225-238. PMID 33189037 — tags: [liver-lung-metastasis, systematic-review] — cited by: wiki/liver-and-lung-metastasis.md
• Dueland S, et al. Survival Following Liver Transplantation for Patients With Nonresectable Liver-only Colorectal Metastases. Ann Surg. 2020;271(2):212-218. PMID 31188200 — tags: [liver-lung-metastasis, survivorship] — cited by: literature/statistics/STATISTICS.md, wiki/clinical-trials-landscape.md, wiki/liver-and-lung-metastasis.md
• Dueland S, et al. Selection criteria related to long-term survival following liver transplantation for colorectal liver metastasis. Am J Transplant. 2020;20(2):530-537. PMID 31674105 — tags: [liver-lung-metastasis, survivorship] — cited by: wiki/liver-and-lung-metastasis.md
• Line PD, et al. Liver transplantation for colorectal liver metastases: What do we need to know? Int J Surg. 2020;82S:87-92. PMID 32305529 — tags: [liver-lung-metastasis] — cited by: wiki/liver-and-lung-metastasis.md
• Milosevic M, et al. Pulmonary Metastasectomy in Colorectal Cancer: updated analysis of 93 randomized patients - control survival is much better than previously assumed. Colorectal Dis. 2020;22(10):1314-1324. PMID 32388895 — tags: [liver-lung-metastasis, randomized-trial, survivorship] — cited by: literature/statistics/STATISTICS.md, wiki/guidelines.md, wiki/liver-and-lung-metastasis.md
• Smedman TM, et al. Liver transplantation for unresectable colorectal liver metastases in patients and donors with extended criteria (SECA-II arm D study). BJS Open. 2020;4(3):467-477. PMID 32333527 — tags: [liver-lung-metastasis] — cited by: literature/statistics/STATISTICS.md, wiki/clinical-trials-landscape.md, wiki/liver-and-lung-metastasis.md
• Maspero M, et al. Liver Transplantation for Hepatic Metastases from Colorectal Cancer: Current Knowledge and Open Issues. Cancers (Basel). 2023;15(2). PMID 36672295 — tags: [liver-lung-metastasis] — cited by: wiki/liver-and-lung-metastasis.md
• Bregni G, et al. Systemic chemotherapy for patients with resectable or resected colorectal cancer liver metastases: An individual patient data meta-analysis. Eur J Cancer. 2025;231:116092. PMID 41197289 — tags: [liver-lung-metastasis, meta-analysis] — cited by: wiki/liver-and-lung-metastasis.md
• Su L, et al. Thermal ablation versus liver resection for small colorectal liver metastases (≤3 cm): a systematic review and meta-analysis of randomized and propensity score-matched studies. Surg Endosc. 2026. PMID 42463528 — tags: [liver-lung-metastasis, randomized-trial, meta-analysis, systematic-review] — cited by: wiki/liver-and-lung-metastasis.md

Survivorship and late effects

• Harrington CB, et al. It's not over when it's over: long-term symptoms in cancer survivors--a systematic review. Int J Psychiatry Med. 2010;40(2):163-81. PMID 20848873 — tags: [survivorship-late-effects, systematic-review, survivorship] — cited by: literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Emmertsen KJ, Laurberg S. Low anterior resection syndrome score: development and validation of a symptom-based scoring system for bowel dysfunction after low anterior resection for rectal cancer. Ann Surg. 2012;255(5):922-8. PMID 22504191 — tags: [survivorship-late-effects] — cited by: wiki/survivorship-and-late-effects.md
• Pachler J, Wille-Jørgensen P. Quality of life after rectal resection for cancer, with or without permanent colostomy. Cochrane Database Syst Rev. 2012;12(12):CD004323. PMID 23235607 — tags: [survivorship-late-effects] — cited by: literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Keane C, et al. Defining low anterior resection syndrome: a systematic review of the literature. Colorectal Dis. 2017;19(8):713-722. PMID 28612460 — tags: [survivorship-late-effects, systematic-review] — cited by: wiki/survivorship-and-late-effects.md
• Arthur EK, Wills CE, Menon U. A Systematic Review of Interventions for Sexual Well-Being in Women With Gynecologic, Anal, or Rectal Cancer. Oncol Nurs Forum. 2018;45(4):469-482. PMID 29947348 — tags: [survivorship-late-effects, systematic-review] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Kuriyama A, Endo K. Goshajinkigan for prevention of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis. Support Care Cancer. 2018;26(4):1051-1059. PMID 29280005 — tags: [survivorship-late-effects, meta-analysis, systematic-review] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/red-flags-and-safety-concerns.md, wiki/survivorship-and-late-effects.md
• Hassan C, et al. Endoscopic surveillance after surgical or endoscopic resection for colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Digestive Oncology (ESDO) Guideline. Endoscopy. 2019;51(3):266-277. PMID 30722071 — tags: [survivorship-late-effects, guideline] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md, wiki/survivorship-and-late-effects.md
• Nguyen TH, Chokshi RV. Low Anterior Resection Syndrome. Curr Gastroenterol Rep. 2020;22(10):48. PMID 32749603 — tags: [survivorship-late-effects] — cited by: wiki/survivorship-and-late-effects.md
• Rutherford C, et al. Patient-reported outcomes and experiences from the perspective of colorectal cancer survivors: meta-synthesis of qualitative studies. J Patient Rep Outcomes. 2020;4(1):27. PMID 32335745 — tags: [survivorship-late-effects, survivorship] — cited by: literature/patient-voice/README.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Wiltink LM, et al. Systematic review of clinical practice guidelines for colorectal and anal cancer: the extent of recommendations for managing long-term symptoms and functional impairments. Support Care Cancer. 2020;28(6):2523-2532. PMID 32025805 — tags: [survivorship-late-effects, guideline, systematic-review] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Hardiman KM, et al. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Surveillance and Survivorship Care of Patients After Curative Treatment of Colon and Rectal Cancer. Dis Colon Rectum. 2021;64(5):517-533. PMID 33591043 — tags: [survivorship-late-effects, guideline, survivorship] — cited by: literature/guidelines/REGISTRY.md, wiki/survivorship-and-late-effects.md
• Pape E, et al. Experiences and needs of patients with rectal cancer confronted with bowel problems after stoma reversal: A systematic review and thematic-synthesis. Eur J Oncol Nurs. 2021;54:102018. PMID 34543812 — tags: [survivorship-late-effects, systematic-review] — cited by: literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Wallington DG, Holliday EB. Preparing Patients for Sexual Dysfunction After Radiation for Anorectal Cancers: A Systematic Review. Pract Radiat Oncol. 2021;11(3):193-201. PMID 32777386 — tags: [survivorship-late-effects, systematic-review] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Bhimani N, et al. Cost of treating metastatic colorectal cancer: a systematic review. Public Health. 2022;211:97-104. PMID 36063775 — tags: [survivorship-late-effects, systematic-review] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Dawood ZS, et al. Colonoscopy, imaging, and carcinoembryonic antigen: Comparison of guideline adherence to surveillance strategies in patients who underwent resection of colorectal cancer - A systematic review and meta-analysis. Surg Oncol. 2023;47:101910. PMID 36806402 — tags: [survivorship-late-effects, guideline, meta-analysis] — cited by: wiki/guidelines.md, wiki/survivorship-and-late-effects.md
• Meurs J, et al. Low anterior resection syndrome (LARS) and quality of life after colectomy. Int J Colorectal Dis. 2023;38(1):180. PMID 37369860 — tags: [survivorship-late-effects] — cited by: wiki/survivorship-and-late-effects.md
• Azzani M, et al. Subjective and objective financial toxicity among colorectal cancer patients: a systematic review. BMC Cancer. 2024;24(1):40. PMID 38182993 — tags: [survivorship-late-effects, systematic-review] — cited by: OPEN-QUESTIONS.md, literature/patient-voice/README.md, literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Fernandes D, et al. Non-gastrointestinal symptom burden following colorectal cancer treatment-a systematic review. Support Care Cancer. 2024;32(10):699. PMID 39361213 — tags: [survivorship-late-effects, systematic-review] — cited by: literature/patient-voice/sources.md, wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md
• Raichurkar P, et al. Undergoing Cytoreductive Surgery for Colorectal Peritoneal Metastases: A Qualitative Exploration of the Lived Experiences of Patients and Carers. Ann Surg Oncol. 2025;32(7):5042-5050. PMID 40295419 — tags: [survivorship-late-effects] — cited by: wiki/patient-experience-and-advocacy.md, wiki/survivorship-and-late-effects.md

Guidelines and standards

• Arezzo A, et al. Stent as bridge to surgery for left-sided malignant colonic obstruction reduces adverse events and stoma rate compared with emergency surgery: results of a systematic review and meta-analysis of randomized controlled trials. Gastrointest Endosc. 2017;86(3):416-426. PMID 28392363 — tags: [guidelines-standards, randomized-trial, meta-analysis] — cited by: wiki/guidelines.md, wiki/red-flags-and-safety-concerns.md
• Cervantes A, et al. Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2023;34(1):10-32. PMID 36307056 — tags: [guidelines-standards, guideline] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md
• Scott AJ, et al. Management of Locally Advanced Rectal Cancer: ASCO Guideline. J Clin Oncol. 2024;42(28):3355-3375. PMID 39116386 — tags: [guidelines-standards, guideline] — cited by: literature/guidelines/REGISTRY.md, wiki/guidelines.md

Biomarkers and liquid biopsy

• McCall JL, et al. The value of serum carcinoembryonic antigen in predicting recurrent disease following curative resection of colorectal cancer. Dis Colon Rectum. 1994;37(9):875-81. PMID 8076486 — tags: [biomarkers-liquid-biopsy] — cited by: wiki/biomarkers-and-liquid-biopsy.md
• Petit J, et al. Cell-Free DNA as a Diagnostic Blood-Based Biomarker for Colorectal Cancer: A Systematic Review. J Surg Res. 2019;236:184-197. PMID 30694754 — tags: [biomarkers-liquid-biopsy, systematic-review] — cited by: wiki/biomarkers-and-liquid-biopsy.md
• Taieb J, et al. Prognostic Value and Relation with Adjuvant Treatment Duration of ctDNA in Stage III Colon Cancer: a Post Hoc Analysis of the PRODIGE-GERCOR IDEA-France Trial. Clin Cancer Res. 2021;27(20):5638-5646. PMID 34083233 — tags: [biomarkers-liquid-biopsy] — cited by: wiki/biomarkers-and-liquid-biopsy.md
• Young GP, et al. Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancer. Clin Epigenetics. 2021;13(1):14. PMID 33478584 — tags: [biomarkers-liquid-biopsy] — cited by: wiki/biomarkers-and-liquid-biopsy.md
• Hoang T, et al. Utility of circulating tumor DNA to detect minimal residual disease in colorectal cancer: A systematic review and network meta-analysis. Int J Cancer. 2025;157(4):722-740. PMID 40293388 — tags: [biomarkers-liquid-biopsy, meta-analysis, systematic-review] — cited by: wiki/biomarkers-and-liquid-biopsy.md
• Martínez-Castedo B, et al. Minimal residual disease in colorectal cancer. Tumor-informed versus tumor-agnostic approaches: unraveling the optimal strategy. Ann Oncol. 2025;36(3):263-276. PMID 39675560 — tags: [biomarkers-liquid-biopsy] — cited by: wiki/biomarkers-and-liquid-biopsy.md
• Hlauschek D, et al. Common analysis pitfalls in longitudinal ctDNA studies: lead time, sensitivity and immortal time bias. EBioMedicine. 2026;130:106407. PMID 42508231 — tags: [biomarkers-liquid-biopsy] — cited by: wiki/biomarkers-and-liquid-biopsy.md
• Khan AU, et al. Circulating Tumor DNA as a Biomarker for Recurrence After Curative Resection of Colorectal Cancer Liver Metastases: A Systematic Review and Meta-Analysis. Clin Colorectal Cancer. 2026;25(2):181-190.e1. PMID 41723037 — tags: [biomarkers-liquid-biopsy, meta-analysis, systematic-review] — cited by: wiki/biomarkers-and-liquid-biopsy.md

Patient experience and advocacy

• Travis E, et al. Barriers to flexible sigmoidoscopy colorectal cancer screening in low uptake socio-demographic groups: A systematic review. Psychooncology. 2020;29(8):1237-1247. PMID 32539187 — tags: [patient-experience-advocacy, systematic-review, screening] — cited by: literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md
• Le Bonniec A, et al. Barriers and Facilitators to Participation in Health Screening: an Umbrella Review Across Conditions. Prev Sci. 2022;23(7):1115-1142. PMID 35705780 — tags: [patient-experience-advocacy, screening] — cited by: literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md
• Mol MJ, et al. Mental Health in Familial Adenomatous Polyposis: A Systematic Review. Psychooncology. 2025;34(5):e70176. PMID 40356044 — tags: [patient-experience-advocacy, systematic-review] — cited by: literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md
• Yeniğűn Akbulut SC, Ilgaz A. Psychosocial effects and quality of life after stoma surgery: systematic review and qualitative meta-synthesis. BMC Psychol. 2026;14(1). PMID 41578363 — tags: [patient-experience-advocacy, systematic-review] — cited by: literature/patient-voice/sources.md, literature/patient-voice/themes.md, wiki/patient-experience-and-advocacy.md

Red flags and safety

• Wyrzykowski AD, et al. Emergent right hemicolectomies. Am Surg. 2005;71(8):653-6; discussion 656-7. PMID 16217947 — tags: [red-flags-safety] — cited by: wiki/red-flags-and-safety-concerns.md
• Hahn KK, Wolff JJ, Kolesar JM. Pharmacogenetics and irinotecan therapy. Am J Health Syst Pharm. 2006;63(22):2211-7. PMID 17090741 — tags: [red-flags-safety] — cited by: wiki/red-flags-and-safety-concerns.md
• Cao Y, et al. A meta-analysis of randomized controlled trials comparing chemotherapy plus bevacizumab with chemotherapy alone in metastatic colorectal cancer. Int J Colorectal Dis. 2009;24(6):677-85. PMID 19184059 — tags: [red-flags-safety, randomized-trial, meta-analysis] — cited by: wiki/red-flags-and-safety-concerns.md
• Mirza NN, McCloud JM, Cheetham MJ. Clostridium septicum sepsis and colorectal cancer - a reminder. World J Surg Oncol. 2009;7:73. PMID 19807912 — tags: [red-flags-safety] — cited by: wiki/red-flags-and-safety-concerns.md
• De Ceglie A, et al. A meta-analysis of endoscopic stenting as bridge to surgery versus emergency surgery for left-sided colorectal cancer obstruction. Crit Rev Oncol Hematol. 2013;88(2):387-403. PMID 23845505 — tags: [red-flags-safety, meta-analysis] — cited by: wiki/red-flags-and-safety-concerns.md
• Kelly C, et al. Use of raltitrexed as an alternative to 5-fluorouracil and capecitabine in cancer patients with cardiac history. Eur J Cancer. 2013;49(10):2303-10. PMID 23583220 — tags: [red-flags-safety] — cited by: wiki/red-flags-and-safety-concerns.md
• Huang X, et al. Preoperative colonic stents versus emergency surgery for acute left-sided malignant colonic obstruction: a meta-analysis. J Gastrointest Surg. 2014;18(3):584-91. PMID 24170606 — tags: [red-flags-safety, meta-analysis] — cited by: wiki/red-flags-and-safety-concerns.md
• Matsuda A, et al. Comparison of long-term outcomes of colonic stent as "bridge to surgery" and emergency surgery for malignant large-bowel obstruction: a meta-analysis. Ann Surg Oncol. 2015;22(2):497-504. PMID 25120255 — tags: [red-flags-safety, meta-analysis] — cited by: wiki/red-flags-and-safety-concerns.md
• Botrel TEA, et al. Efficacy and safety of bevacizumab plus chemotherapy compared to chemotherapy alone in previously untreated advanced or metastatic colorectal cancer: a systematic review and meta-analysis. BMC Cancer. 2016;16(1):677. PMID 27558497 — tags: [red-flags-safety, meta-analysis, systematic-review] — cited by: wiki/red-flags-and-safety-concerns.md
• Deenen MJ, et al. Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis. J Clin Oncol. 2016;34(3):227-34. PMID 26573078 — tags: [red-flags-safety] — cited by: wiki/red-flags-and-safety-concerns.md
• Allievi N, et al. Endoscopic Stenting as Bridge to Surgery versus Emergency Resection for Left-Sided Malignant Colorectal Obstruction: An Updated Meta-Analysis. Int J Surg Oncol. 2017;2017:2863272. PMID 28761765 — tags: [red-flags-safety, meta-analysis] — cited by: wiki/red-flags-and-safety-concerns.md
• Cecchin E, et al. Host genetic profiling to increase drug safety in colorectal cancer from discovery to implementation. Drug Resist Updat. 2018;39:18-40. PMID 30075835 — tags: [red-flags-safety] — cited by: wiki/red-flags-and-safety-concerns.md
• Spannenburg L, et al. Surgical outcomes of colonic stents as a bridge to surgery versus emergency surgery for malignant colorectal obstruction: A systematic review and meta-analysis of high quality prospective and randomised controlled trials. Eur J Surg Oncol. 2020;46(8):1404-1414. PMID 32418754 — tags: [red-flags-safety, randomized-trial, meta-analysis] — cited by: wiki/red-flags-and-safety-concerns.md
• Kanaka S, et al. Colonic stent as a bridge to surgery versus emergency resection for right-sided malignant large bowel obstruction: a meta-analysis. Surg Endosc. 2022;36(5):2760-2770. PMID 35113211 — tags: [red-flags-safety, meta-analysis] — cited by: wiki/red-flags-and-safety-concerns.md
• McKechnie T, et al. Management of left-sided malignant colorectal obstructions with curative intent: a network meta-analysis. Surg Endosc. 2023;37(6):4159-4178. PMID 36869265 — tags: [red-flags-safety, meta-analysis] — cited by: wiki/red-flags-and-safety-concerns.md
• Ogawa K, et al. Prolonged door-to-antibiotics time is associated with high hospital mortality in patients with perforated colorectal peritonitis. Langenbecks Arch Surg. 2023;408(1):220. PMID 37261545 — tags: [red-flags-safety] — cited by: wiki/red-flags-and-safety-concerns.md

Guideline registry

• Labianca R, et al. Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24 Suppl 6:vi64-72. PMID 24078664 — tags: [guideline-registry, guideline] — cited by: literature/guidelines/REGISTRY.md
• US Preventive Services Task Force, et al. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement. JAMA. 2016;315(23):2564-2575. PMID 27304597 — tags: [guideline-registry, screening] — cited by: literature/guidelines/REGISTRY.md
• Glynne-Jones R, et al. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017;28(suppl_4):iv22-iv40. PMID 28881920 — tags: [guideline-registry, guideline] — cited by: literature/guidelines/REGISTRY.md
• Benson AB, et al. NCCN Guidelines Insights: Colon Cancer, Version 2.2018. J Natl Compr Canc Netw. 2018;16(4):359-369. PMID 29632055 — tags: [guideline-registry, guideline] — cited by: literature/guidelines/REGISTRY.md
• Costas-Chavarri A, et al. Treatment of Patients With Early-Stage Colorectal Cancer: ASCO Resource-Stratified Guideline. J Glob Oncol. 2019;5:1-19. PMID 30802158 — tags: [guideline-registry, guideline] — cited by: literature/guidelines/REGISTRY.md
• Argilés G, et al. Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020;31(10):1291-1305. PMID 32702383 — tags: [guideline-registry, guideline] — cited by: literature/guidelines/REGISTRY.md
• Benson AB, et al. NCCN Guidelines Insights: Rectal Cancer, Version 6.2020. J Natl Compr Canc Netw. 2020;18(7):806-815. PMID 32634771 — tags: [guideline-registry, guideline] — cited by: literature/guidelines/REGISTRY.md
• Chiorean EG, et al. Treatment of Patients With Late-Stage Colorectal Cancer: ASCO Resource-Stratified Guideline. JCO Glob Oncol. 2020;6:414-438. PMID 32150483 — tags: [guideline-registry, guideline] — cited by: literature/guidelines/REGISTRY.md
• Yoshino T, et al. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis treatment and follow-up of patients with localised colon cancer. Ann Oncol. 2021;32(12):1496-1510. PMID 34411693 — tags: [guideline-registry, guideline] — cited by: literature/guidelines/REGISTRY.md
• Benson AB, et al. NCCN Guidelines® Insights: Rectal Cancer, Version 3.2024. J Natl Compr Canc Netw. 2024;22(6):366-375. PMID 39151454 — tags: [guideline-registry, guideline] — cited by: literature/guidelines/REGISTRY.md

Research frontier

• Gupta S, et al. Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2020;158(4):1131-1153.e5. PMID 32044092 — tags: [research-frontier] — cited by: OPEN-QUESTIONS.md, literature/guidelines/REGISTRY.md
• Shaukat A, et al. ACG Clinical Guidelines: Colorectal Cancer Screening 2021. Am J Gastroenterol. 2021;116(3):458-479. PMID 33657038 — tags: [research-frontier, guideline, screening] — cited by: OPEN-QUESTIONS.md, literature/guidelines/REGISTRY.md