{
 "condition": "type-1-diabetes",
 "date": "2026-10-29",
 "date_from": "2026-08-28",
 "date_to": "2026-10-29",
 "window_decision": "Full window re-searched in PubMed (dp 2026/08/28–2026/10/29). Triage limited to the 101 PMIDs absent from the 2026-10-15 and 2026-10-22 manifests, plus follow-up items those sweeps left (teplizumab/EBV-HLH full text; organization-reported renal-treatment and tegoprubart developments).",
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   "title": "AIRE Deficiency Impairs Thymic Epithelial Progenitor Differentiation from Mouse Embryonic Stem Cells and Accelerates Type 1 Diabetes in NOD/Ltj Mice.",
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   "title": "National clinical audits as distributed diabetes surveillance infrastructure: Consensus lessons from Ireland.",
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   "title": "GLP-1-Based Therapy in Type 1 Diabetes: Balancing Efficacy, Safety, and Patient Selection.",
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   "change": "bibliography-only -> cited in disease-modifying-immunotherapy.md after full-text read (PMC13594791)"
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    "FINE-ONE (Finerenone Efficacy and Safety in Chronic Kidney Disease and Type One Diabetes) was the first successful phase 3 clinical trial in >30 years in people with type 1 diabetes and CKD",
    "median UACR decreased from 574.6 to 373.5 mg/g with finerenone and from 506.4 to 475.6 mg/g with placebo, corresponding to a placebo-corrected UACR change of −25% (95% CI −35%, −13%; P = 0.0001)",
    "Treatment discontinuation because of hyperkalemia was infrequent, occurring in none of the 120 participants receiving placebo and in two of 119 participants receiving finerenone (1.7%)",
    "the relatively short 6-month treatment period constrained the ability to evaluate longer-term kidney outcomes"
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   "pmid": "42927222",
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   "quotes": [
    "the acute change in eGFR from baseline to 1 month postrandomization was greater with finerenone (−2.78 ml/min per 1.73 m2 [95% CI, −4.15 to −1.40]) versus placebo (−0.78 ml/min per 1.73 m2 [95% CI, −2.22 to 0.66]), with a treatment difference of –1.99 ml/min per 1.73 m2 (95% CI, –3.97 to –0.01 [P = 0.049])",
    "It was partially reversible after treatment discontinuation at follow-up.",
    "comparisons between dip categories are no longer protected by randomization"
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   "source": "Europe PMC fullTextXML",
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    "A 44-year-old man with trisomy 21 and stage 2 T1D received a standard 14-day teplizumab course",
    "EBV PCR was not performed immediately before teplizumab administration.",
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    "The HScore was 238, corresponding to a >98% probability of secondary HLH",
    "Renal replacement therapy was required for ∼2 weeks",
    "At 12-month follow-up, the patient remained clinically stable with stage 2 T1D (HbA1c 5.9% [41 mmol/mol], fasting plasma glucose 96 mg/dL [5.3 mmol/L], and no insulin treatment)",
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    "42802417",
    "42802057",
    "42797879",
    "42792959",
    "42782737",
    "42778262",
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    "42362970",
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    "42009279",
    "41915459",
    "41733533",
    "41545210"
   ],
   "topic": "immunopathogenesis"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (genetics OR HLA OR enterovirus OR microbiome OR environmental) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"genetic\"[All Fields] OR \"genetical\"[All Fields] OR \"genetically\"[All Fields] OR \"genetics\"[MeSH Subheading] OR \"genetics\"[All Fields] OR \"genetics\"[MeSH Terms] OR (\"hla\"[Journal] OR \"hla\"[All Fields]) OR (\"enterovirus\"[MeSH Terms] OR \"enterovirus\"[All Fields]) OR (\"microbiome s\"[All Fields] OR \"microbiomic\"[All Fields] OR \"microbiomics\"[All Fields] OR \"microbiota\"[MeSH Terms] OR \"microbiota\"[All Fields] OR \"microbiome\"[All Fields] OR \"microbiomes\"[All Fields]) OR (\"environment\"[MeSH Terms] OR \"environment\"[All Fields] OR \"environmental\"[All Fields] OR \"environmentally\"[All Fields] OR \"environmentals\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 195,
   "ids": [
    "42943299",
    "42942062",
    "42941952",
    "42938275",
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   ],
   "topic": "genetics-environment"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (screening OR \"early detection\" OR cost-effectiveness OR \"cost effectiveness\") AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"diagnosis\"[MeSH Subheading] OR \"diagnosis\"[All Fields] OR \"screening\"[All Fields] OR \"mass screening\"[MeSH Terms] OR (\"mass\"[All Fields] AND \"screening\"[All Fields]) OR \"mass screening\"[All Fields] OR \"early detection of cancer\"[MeSH Terms] OR (\"early\"[All Fields] AND \"detection\"[All Fields] AND \"cancer\"[All Fields]) OR \"early detection of cancer\"[All Fields] OR \"screen\"[All Fields] OR \"screenings\"[All Fields] OR \"screened\"[All Fields] OR \"screens\"[All Fields] OR \"early detection\"[All Fields] OR (\"cost effectiveness analysis\"[MeSH Terms] OR (\"cost effectiveness\"[All Fields] AND \"analysis\"[All Fields]) OR \"cost effectiveness analysis\"[All Fields] OR (\"cost\"[All Fields] AND \"effectiveness\"[All Fields]) OR \"cost effectiveness\"[All Fields]) OR \"cost effectiveness\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 272,
   "ids": [
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   ],
   "topic": "screening"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (insulin OR \"continuous glucose monitoring\" OR \"automated insulin delivery\" OR \"closed-loop\" OR \"closed loop\") AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"insulin\"[Supplementary Concept] OR \"insulin\"[All Fields] OR \"insulin\"[MeSH Terms] OR \"insulin s\"[All Fields] OR \"insuline\"[All Fields] OR \"insulinic\"[All Fields] OR \"insulinization\"[All Fields] OR \"insulinized\"[All Fields] OR \"insulins\"[MeSH Terms] OR \"insulins\"[All Fields] OR \"continuous glucose monitoring\"[All Fields] OR \"automated insulin delivery\"[All Fields] OR \"closed-loop\"[All Fields] OR \"closed-loop\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 464,
   "ids": [
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    "42476956",
    "42476949",
    "42474688",
    "42474296",
    "42474167",
    "42473259",
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    "42461939",
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    "42455340",
    "42449473",
    "42448043",
    "42443623",
    "42439827",
    "42439191",
    "42438283",
    "42438052",
    "42432283",
    "42432282",
    "42430938",
    "42430131",
    "42429743",
    "42429615",
    "42426563",
    "42425326",
    "42424112",
    "42423477",
    "42420766",
    "42418171",
    "42411938",
    "42410321",
    "42410316",
    "42409045",
    "42407337",
    "42406897",
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    "42371338",
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    "42283146",
    "42277401",
    "42276316",
    "42269903",
    "42267931",
    "42262529",
    "42258635",
    "42246173",
    "42241891",
    "42234494",
    "42219533",
    "42208318",
    "42190899",
    "42189218",
    "42184542",
    "42169365",
    "42163482",
    "42162762",
    "42130086",
    "42119975",
    "42119276",
    "42060373",
    "42044156",
    "42030705",
    "42025651",
    "42008285",
    "41983933",
    "41968580",
    "41968498",
    "41966452",
    "41947337",
    "41915459",
    "41914386",
    "41904365",
    "41882966",
    "41879821",
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    "40808595",
    "40607635",
    "40331898",
    "40260699",
    "40207786",
    "40159903"
   ],
   "topic": "insulin-technology"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (teplizumab OR abatacept OR rituximab OR antithymocyte OR verapamil OR immunotherapy OR \"low-dose IL-2\" OR \"GAD-alum\") AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"teplizumab\"[Supplementary Concept] OR \"teplizumab\"[All Fields] OR (\"abatacept\"[Supplementary Concept] OR \"abatacept\"[All Fields] OR \"abatacept\"[MeSH Terms]) OR (\"rituximab\"[Supplementary Concept] OR \"rituximab\"[All Fields] OR \"rituximab\"[MeSH Terms] OR \"rituximab s\"[All Fields]) OR (\"antithymocyte\"[All Fields] OR \"antithymocytic\"[All Fields]) OR (\"verapamil\"[Supplementary Concept] OR \"verapamil\"[All Fields] OR \"verapamil\"[MeSH Terms] OR \"verapamil s\"[All Fields]) OR (\"immunotherapy\"[MeSH Terms] OR \"immunotherapy\"[All Fields] OR \"immunotherapies\"[All Fields] OR \"immunotherapy s\"[All Fields]) OR \"low-dose IL-2\"[All Fields] OR \"GAD-alum\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 48,
   "ids": [
    "42946247",
    "42920033",
    "42909882",
    "42908608",
    "42901255",
    "42895779",
    "42887691",
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    "42850666",
    "42834840",
    "42822480",
    "42812022",
    "42808315",
    "42806034",
    "42802417",
    "42778314",
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    "42738899",
    "42737905",
    "42724548",
    "42720753",
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    "42694947",
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    "42663626",
    "42634089",
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    "42625911",
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    "42520060",
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    "42456777",
    "42442554",
    "42432282",
    "42411999",
    "42405898",
    "42361719",
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    "42269843",
    "42251204",
    "42163482",
    "42138126",
    "42060373",
    "41879139"
   ],
   "topic": "immunotherapy"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (\"islet transplantation\" OR \"stem-cell\" OR \"stem cell\" OR zimislecel OR hypoimmune OR encapsulation OR VX-880 OR VX-264) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"islet transplantation\"[All Fields] OR \"stem-cell\"[All Fields] OR \"stem-cell\"[All Fields] OR \"zimislecel\"[All Fields] OR \"hypoimmune\"[All Fields] OR (\"encapsulant\"[All Fields] OR \"encapsulants\"[All Fields] OR \"encapsulate\"[All Fields] OR \"encapsulated\"[All Fields] OR \"encapsulates\"[All Fields] OR \"encapsulating\"[All Fields] OR \"encapsulation\"[All Fields] OR \"encapsulations\"[All Fields] OR \"encapsulators\"[All Fields] OR \"encapsuled\"[All Fields]) OR \"VX-880\"[All Fields] OR \"VX-264\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 39,
   "ids": [
    "42949132",
    "42941952",
    "42928611",
    "42928449",
    "42926365",
    "42923301",
    "42908675",
    "42907150",
    "42898925",
    "42887499",
    "42876362",
    "42869305",
    "42865487",
    "42850666",
    "42816465",
    "42816440",
    "42811814",
    "42808120",
    "42789342",
    "42787837",
    "42774728",
    "42750143",
    "42743864",
    "42741944",
    "42739778",
    "42722448",
    "42711287",
    "42697977",
    "42690930",
    "42679324",
    "42666090",
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    "42608595",
    "42571658",
    "42517907",
    "42439827",
    "42411999",
    "42387220",
    "41728887"
   ],
   "topic": "cell-replacement"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (hypoglycemia OR hypoglycaemia OR glucagon OR \"impaired awareness\") AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"hypoglycaemia\"[All Fields] OR \"hypoglycemia\"[MeSH Terms] OR \"hypoglycemia\"[All Fields] OR \"hypoglycaemias\"[All Fields] OR \"hypoglycemias\"[All Fields] OR (\"hypoglycaemia\"[All Fields] OR \"hypoglycemia\"[MeSH Terms] OR \"hypoglycemia\"[All Fields] OR \"hypoglycaemias\"[All Fields] OR \"hypoglycemias\"[All Fields]) OR (\"glucagon\"[Supplementary Concept] OR \"glucagon\"[All Fields] OR \"glucagon\"[MeSH Terms] OR \"glucagone\"[All Fields] OR \"glucagons\"[All Fields] OR \"glucagon s\"[All Fields]) OR \"impaired awareness\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 163,
   "ids": [
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    "42707966",
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    "42687770",
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    "42684963",
    "42678336",
    "42676757",
    "42675550",
    "42675375",
    "42675218",
    "42671562",
    "42671087",
    "42669381",
    "42667391",
    "42667348",
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    "42638087",
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    "42608595",
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    "42598998",
    "42580597",
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    "42533279",
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    "42527001",
    "42526999",
    "42526998",
    "42526997",
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    "42526995",
    "42526994",
    "42517907",
    "42503314",
    "42488981",
    "42486409",
    "42476949",
    "42474688",
    "42474167",
    "42473259",
    "42467087",
    "42455340",
    "42443623",
    "42438052",
    "42430938",
    "42429743",
    "42426563",
    "42424112",
    "42417985",
    "42410321",
    "42410316",
    "42409045",
    "42406897",
    "42384016",
    "42380553",
    "42361830",
    "42348165",
    "42347980",
    "42338167",
    "42322375",
    "42321600",
    "42319755",
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    "42312577",
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    "41947337",
    "41904365",
    "41837438",
    "41816915",
    "41784095",
    "40607635"
   ],
   "topic": "hypoglycemia"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (retinopathy OR nephropathy OR neuropathy OR cardiovascular OR complications) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"retinal diseases\"[MeSH Terms] OR (\"retinal\"[All Fields] AND \"diseases\"[All Fields]) OR \"retinal diseases\"[All Fields] OR \"retinopathies\"[All Fields] OR \"retinopathy\"[All Fields] OR (\"kidney diseases\"[MeSH Terms] OR (\"kidney\"[All Fields] AND \"diseases\"[All Fields]) OR \"kidney diseases\"[All Fields] OR \"nephropathies\"[All Fields] OR \"nephropathy\"[All Fields]) OR (\"neuropathies\"[All Fields] OR \"neuropathy\"[All Fields]) OR (\"cardiovascular system\"[MeSH Terms] OR (\"cardiovascular\"[All Fields] AND \"system\"[All Fields]) OR \"cardiovascular system\"[All Fields] OR \"cardiovascular\"[All Fields] OR \"cardiovasculars\"[All Fields]) OR (\"complicances\"[All Fields] OR \"complicate\"[All Fields] OR \"complicated\"[All Fields] OR \"complicates\"[All Fields] OR \"complicating\"[All Fields] OR \"complication\"[All Fields] OR \"complication s\"[All Fields] OR \"complications\"[MeSH Subheading] OR \"complications\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 342,
   "ids": [
    "42951245",
    "42949836",
    "42949632",
    "42944644",
    "42944608",
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    "42938261",
    "42938178",
    "42931559",
    "42930010",
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    "42448043",
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    "42362970",
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    "42303108",
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    "42283146",
    "42270944",
    "42258635",
    "42251204",
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    "42208083",
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    "42169365",
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    "42162840",
    "42162762",
    "42128812",
    "42119975",
    "42119276",
    "42117336",
    "42114588",
    "42104992",
    "42095877",
    "42091850",
    "42087708",
    "42044156",
    "42025651",
    "42009279",
    "42008285",
    "41983933",
    "41981796",
    "41968580",
    "41931209",
    "41904365",
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    "41876711",
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    "41649970",
    "41607087",
    "41290372",
    "40607635",
    "40260699",
    "40207786"
   ],
   "topic": "complications"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (distress OR psychosocial OR behavioral OR behavioural OR \"eating disorder\" OR transition OR \"quality of life\") AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"distress\"[All Fields] OR \"distressed\"[All Fields] OR \"distresses\"[All Fields] OR \"distressful\"[All Fields] OR \"distressing\"[All Fields] OR (\"psychosocial\"[All Fields] OR \"psychosocially\"[All Fields]) OR (\"behavior s\"[All Fields] OR \"behaviorally\"[All Fields] OR \"behaviour\"[All Fields] OR \"behavior\"[MeSH Terms] OR \"behavior\"[All Fields] OR \"behavioural\"[All Fields] OR \"behavioral\"[All Fields] OR \"behaviourally\"[All Fields] OR \"behaviours\"[All Fields] OR \"behaviors\"[All Fields] OR \"pattern\"[All Fields] OR \"pattern s\"[All Fields] OR \"patternability\"[All Fields] OR \"patternable\"[All Fields] OR \"patterned\"[All Fields] OR \"patterning\"[All Fields] OR \"patternings\"[All Fields] OR \"patterns\"[All Fields]) OR (\"behavior s\"[All Fields] OR \"behaviorally\"[All Fields] OR \"behaviour\"[All Fields] OR \"behavior\"[MeSH Terms] OR \"behavior\"[All Fields] OR \"behavioural\"[All Fields] OR \"behavioral\"[All Fields] OR \"behaviourally\"[All Fields] OR \"behaviours\"[All Fields] OR \"behaviors\"[All Fields] OR \"pattern\"[All Fields] OR \"pattern s\"[All Fields] OR \"patternability\"[All Fields] OR \"patternable\"[All Fields] OR \"patterned\"[All Fields] OR \"patterning\"[All Fields] OR \"patternings\"[All Fields] OR \"patterns\"[All Fields]) OR \"eating disorder\"[All Fields] OR (\"transit\"[All Fields] OR \"transited\"[All Fields] OR \"transiting\"[All Fields] OR \"transition\"[All Fields] OR \"transitional\"[All Fields] OR \"transitionals\"[All Fields] OR \"transitioned\"[All Fields] OR \"transitioning\"[All Fields] OR \"transitions\"[All Fields] OR \"transits\"[All Fields]) OR \"quality of life\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 268,
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   ],
   "topic": "psychosocial"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (guideline OR consensus OR \"Standards of Care\" OR ISPAD OR NICE OR AACE OR EASD) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"guideline\"[Publication Type] OR \"guidelines as topic\"[MeSH Terms] OR \"guideline\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR \"Standards of Care\"[All Fields] OR \"ISPAD\"[All Fields] OR \"NICE\"[All Fields] OR \"AACE\"[All Fields] OR \"EASD\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 61,
   "ids": [
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    "42944644",
    "42895779",
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    "41681035",
    "40159903"
   ],
   "topic": "guidelines"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (biomarker OR \"C-peptide\" OR autoantibody OR prediction) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"biomarker s\"[All Fields] OR \"biomarkers\"[Supplementary Concept] OR \"biomarkers\"[All Fields] OR \"biomarker\"[All Fields] OR \"biomarkers\"[MeSH Terms] OR \"C-peptide\"[All Fields] OR (\"autoantibodies\"[Supplementary Concept] OR \"autoantibodies\"[All Fields] OR \"autoantibodies\"[MeSH Terms] OR \"autoantibody\"[All Fields]) OR (\"predict\"[All Fields] OR \"predictabilities\"[All Fields] OR \"predictability\"[All Fields] OR \"predictable\"[All Fields] OR \"predictably\"[All Fields] OR \"predicted\"[All Fields] OR \"predicting\"[All Fields] OR \"prediction\"[All Fields] OR \"predictions\"[All Fields] OR \"predictive\"[All Fields] OR \"predictively\"[All Fields] OR \"predictiveness\"[All Fields] OR \"predictives\"[All Fields] OR \"predictivities\"[All Fields] OR \"predictivity\"[All Fields] OR \"predicts\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 250,
   "ids": [
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   ],
   "topic": "biomarkers"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (\"clinical trial\" OR randomized OR randomised) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"clinical trial\"[All Fields] OR (\"random allocation\"[MeSH Terms] OR (\"random\"[All Fields] AND \"allocation\"[All Fields]) OR \"random allocation\"[All Fields] OR \"randomization\"[All Fields] OR \"randomized\"[All Fields] OR \"random\"[All Fields] OR \"randomisation\"[All Fields] OR \"randomisations\"[All Fields] OR \"randomise\"[All Fields] OR \"randomised\"[All Fields] OR \"randomising\"[All Fields] OR \"randomizations\"[All Fields] OR \"randomize\"[All Fields] OR \"randomizes\"[All Fields] OR \"randomizing\"[All Fields] OR \"randomness\"[All Fields] OR \"randoms\"[All Fields]) OR (\"random allocation\"[MeSH Terms] OR (\"random\"[All Fields] AND \"allocation\"[All Fields]) OR \"random allocation\"[All Fields] OR \"randomization\"[All Fields] OR \"randomized\"[All Fields] OR \"random\"[All Fields] OR \"randomisation\"[All Fields] OR \"randomisations\"[All Fields] OR \"randomise\"[All Fields] OR \"randomised\"[All Fields] OR \"randomising\"[All Fields] OR \"randomizations\"[All Fields] OR \"randomize\"[All Fields] OR \"randomizes\"[All Fields] OR \"randomizing\"[All Fields] OR \"randomness\"[All Fields] OR \"randoms\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 150,
   "ids": [
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    "42945539",
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    "42574728",
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    "42545686",
    "42537433",
    "42533279",
    "42526999",
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    "42526991",
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    "42517687",
    "42517200",
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    "42498676",
    "42486409",
    "42473259",
    "42467087",
    "42449473",
    "42432283",
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    "41830209",
    "41816915",
    "41784095",
    "41703423",
    "41681122",
    "40260699"
   ],
   "topic": "clinical-trials"
  },
  {
   "source": "pubmed",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (\"patient experience\" OR qualitative OR advocacy OR access OR stigma) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"patient experience\"[All Fields] OR (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields]) OR (\"advocacies\"[All Fields] OR \"advocacy\"[All Fields] OR \"advocacy s\"[All Fields]) OR (\"access\"[All Fields] OR \"accessed\"[All Fields] OR \"accesses\"[All Fields] OR \"accessibilities\"[All Fields] OR \"accessibility\"[All Fields] OR \"accessible\"[All Fields] OR \"accessing\"[All Fields]) OR (\"social stigma\"[MeSH Terms] OR (\"social\"[All Fields] AND \"stigma\"[All Fields]) OR \"social stigma\"[All Fields] OR \"stigma\"[All Fields] OR \"stigmas\"[All Fields] OR \"stigma s\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 143,
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   ],
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  },
  {
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   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (ketoacidosis OR safety OR \"adverse event\" OR SGLT OR driving OR exercise) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"ketosis\"[MeSH Terms] OR \"ketosis\"[All Fields] OR \"ketoacidosis\"[All Fields] OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]) OR \"adverse event\"[All Fields] OR \"SGLT\"[All Fields] OR (\"automobile driving\"[MeSH Terms] OR (\"automobile\"[All Fields] AND \"driving\"[All Fields]) OR \"automobile driving\"[All Fields] OR \"driving\"[All Fields] OR \"drive\"[MeSH Terms] OR \"drive\"[All Fields] OR \"drives\"[All Fields] OR \"drivings\"[All Fields]) OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 233,
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   ],
   "topic": "safety"
  }
 ],
 "cochrane_queries_via_pubmed": [
  {
   "source": "cochrane-via-pubmed",
   "topic": "staging",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (staging OR progression OR \"natural history\" OR seroconversion) AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"stage\"[All Fields] OR \"staged\"[All Fields] OR \"stages\"[All Fields] OR \"staging\"[All Fields] OR \"stagings\"[All Fields] OR (\"disease progression\"[MeSH Terms] OR (\"disease\"[All Fields] AND \"progression\"[All Fields]) OR \"disease progression\"[All Fields] OR \"progression\"[All Fields] OR \"progress\"[All Fields] OR \"progressed\"[All Fields] OR \"progresses\"[All Fields] OR \"progressing\"[All Fields] OR \"progressions\"[All Fields] OR \"progressive\"[All Fields] OR \"progressively\"[All Fields] OR \"progressives\"[All Fields]) OR \"natural history\"[All Fields] OR (\"seroconversion\"[MeSH Terms] OR \"seroconversion\"[All Fields] OR \"seroconversions\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "burden",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (epidemiology OR incidence OR prevalence OR mortality OR registry OR burden) AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"epidemiologies\"[All Fields] OR \"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"epidemiology\"[MeSH Terms] OR \"epidemiology s\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields]) OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading]) OR (\"registries\"[MeSH Terms] OR \"registries\"[All Fields] OR \"registry\"[All Fields] OR \"registry s\"[All Fields]) OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "immunopathogenesis",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (immunopathogenesis OR insulitis OR \"T-cell\" OR \"beta-cell stress\" OR \"beta cell stress\") AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"immunopathogenesis\"[All Fields] OR \"insulitis\"[All Fields] OR \"T-cell\"[All Fields] OR \"beta-cell stress\"[All Fields] OR \"beta-cell stress\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "genetics-environment",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (genetics OR HLA OR enterovirus OR microbiome OR environmental) AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"genetic\"[All Fields] OR \"genetical\"[All Fields] OR \"genetically\"[All Fields] OR \"genetics\"[MeSH Subheading] OR \"genetics\"[All Fields] OR \"genetics\"[MeSH Terms] OR (\"hla\"[Journal] OR \"hla\"[All Fields]) OR (\"enterovirus\"[MeSH Terms] OR \"enterovirus\"[All Fields]) OR (\"microbiome s\"[All Fields] OR \"microbiomic\"[All Fields] OR \"microbiomics\"[All Fields] OR \"microbiota\"[MeSH Terms] OR \"microbiota\"[All Fields] OR \"microbiome\"[All Fields] OR \"microbiomes\"[All Fields]) OR (\"environment\"[MeSH Terms] OR \"environment\"[All Fields] OR \"environmental\"[All Fields] OR \"environmentally\"[All Fields] OR \"environmentals\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "screening",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (screening OR \"early detection\" OR cost-effectiveness OR \"cost effectiveness\") AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"diagnosis\"[MeSH Subheading] OR \"diagnosis\"[All Fields] OR \"screening\"[All Fields] OR \"mass screening\"[MeSH Terms] OR (\"mass\"[All Fields] AND \"screening\"[All Fields]) OR \"mass screening\"[All Fields] OR \"early detection of cancer\"[MeSH Terms] OR (\"early\"[All Fields] AND \"detection\"[All Fields] AND \"cancer\"[All Fields]) OR \"early detection of cancer\"[All Fields] OR \"screen\"[All Fields] OR \"screenings\"[All Fields] OR \"screened\"[All Fields] OR \"screens\"[All Fields] OR \"early detection\"[All Fields] OR (\"cost effectiveness analysis\"[MeSH Terms] OR (\"cost effectiveness\"[All Fields] AND \"analysis\"[All Fields]) OR \"cost effectiveness analysis\"[All Fields] OR (\"cost\"[All Fields] AND \"effectiveness\"[All Fields]) OR \"cost effectiveness\"[All Fields]) OR \"cost effectiveness\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "insulin-technology",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (insulin OR \"continuous glucose monitoring\" OR \"automated insulin delivery\" OR \"closed-loop\" OR \"closed loop\") AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"insulin\"[Supplementary Concept] OR \"insulin\"[All Fields] OR \"insulin\"[MeSH Terms] OR \"insulin s\"[All Fields] OR \"insuline\"[All Fields] OR \"insulinic\"[All Fields] OR \"insulinization\"[All Fields] OR \"insulinized\"[All Fields] OR \"insulins\"[MeSH Terms] OR \"insulins\"[All Fields] OR \"continuous glucose monitoring\"[All Fields] OR \"automated insulin delivery\"[All Fields] OR \"closed-loop\"[All Fields] OR \"closed-loop\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "immunotherapy",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (teplizumab OR abatacept OR rituximab OR antithymocyte OR verapamil OR immunotherapy OR \"low-dose IL-2\" OR \"GAD-alum\") AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"teplizumab\"[Supplementary Concept] OR \"teplizumab\"[All Fields] OR (\"abatacept\"[Supplementary Concept] OR \"abatacept\"[All Fields] OR \"abatacept\"[MeSH Terms]) OR (\"rituximab\"[Supplementary Concept] OR \"rituximab\"[All Fields] OR \"rituximab\"[MeSH Terms] OR \"rituximab s\"[All Fields]) OR (\"antithymocyte\"[All Fields] OR \"antithymocytic\"[All Fields]) OR (\"verapamil\"[Supplementary Concept] OR \"verapamil\"[All Fields] OR \"verapamil\"[MeSH Terms] OR \"verapamil s\"[All Fields]) OR (\"immunotherapy\"[MeSH Terms] OR \"immunotherapy\"[All Fields] OR \"immunotherapies\"[All Fields] OR \"immunotherapy s\"[All Fields]) OR \"low-dose IL-2\"[All Fields] OR \"GAD-alum\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "cell-replacement",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (\"islet transplantation\" OR \"stem-cell\" OR \"stem cell\" OR zimislecel OR hypoimmune OR encapsulation OR VX-880 OR VX-264) AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"islet transplantation\"[All Fields] OR \"stem-cell\"[All Fields] OR \"stem-cell\"[All Fields] OR \"zimislecel\"[All Fields] OR \"hypoimmune\"[All Fields] OR (\"encapsulant\"[All Fields] OR \"encapsulants\"[All Fields] OR \"encapsulate\"[All Fields] OR \"encapsulated\"[All Fields] OR \"encapsulates\"[All Fields] OR \"encapsulating\"[All Fields] OR \"encapsulation\"[All Fields] OR \"encapsulations\"[All Fields] OR \"encapsulators\"[All Fields] OR \"encapsuled\"[All Fields]) OR \"VX-880\"[All Fields] OR \"VX-264\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "hypoglycemia",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (hypoglycemia OR hypoglycaemia OR glucagon OR \"impaired awareness\") AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"hypoglycaemia\"[All Fields] OR \"hypoglycemia\"[MeSH Terms] OR \"hypoglycemia\"[All Fields] OR \"hypoglycaemias\"[All Fields] OR \"hypoglycemias\"[All Fields] OR (\"hypoglycaemia\"[All Fields] OR \"hypoglycemia\"[MeSH Terms] OR \"hypoglycemia\"[All Fields] OR \"hypoglycaemias\"[All Fields] OR \"hypoglycemias\"[All Fields]) OR (\"glucagon\"[Supplementary Concept] OR \"glucagon\"[All Fields] OR \"glucagon\"[MeSH Terms] OR \"glucagone\"[All Fields] OR \"glucagons\"[All Fields] OR \"glucagon s\"[All Fields]) OR \"impaired awareness\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "complications",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (retinopathy OR nephropathy OR neuropathy OR cardiovascular OR complications) AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"retinal diseases\"[MeSH Terms] OR (\"retinal\"[All Fields] AND \"diseases\"[All Fields]) OR \"retinal diseases\"[All Fields] OR \"retinopathies\"[All Fields] OR \"retinopathy\"[All Fields] OR (\"kidney diseases\"[MeSH Terms] OR (\"kidney\"[All Fields] AND \"diseases\"[All Fields]) OR \"kidney diseases\"[All Fields] OR \"nephropathies\"[All Fields] OR \"nephropathy\"[All Fields]) OR (\"neuropathies\"[All Fields] OR \"neuropathy\"[All Fields]) OR (\"cardiovascular system\"[MeSH Terms] OR (\"cardiovascular\"[All Fields] AND \"system\"[All Fields]) OR \"cardiovascular system\"[All Fields] OR \"cardiovascular\"[All Fields] OR \"cardiovasculars\"[All Fields]) OR (\"complicances\"[All Fields] OR \"complicate\"[All Fields] OR \"complicated\"[All Fields] OR \"complicates\"[All Fields] OR \"complicating\"[All Fields] OR \"complication\"[All Fields] OR \"complication s\"[All Fields] OR \"complications\"[MeSH Subheading] OR \"complications\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "psychosocial",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (distress OR psychosocial OR behavioral OR behavioural OR \"eating disorder\" OR transition OR \"quality of life\") AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"distress\"[All Fields] OR \"distressed\"[All Fields] OR \"distresses\"[All Fields] OR \"distressful\"[All Fields] OR \"distressing\"[All Fields] OR (\"psychosocial\"[All Fields] OR \"psychosocially\"[All Fields]) OR (\"behavior s\"[All Fields] OR \"behaviorally\"[All Fields] OR \"behaviour\"[All Fields] OR \"behavior\"[MeSH Terms] OR \"behavior\"[All Fields] OR \"behavioural\"[All Fields] OR \"behavioral\"[All Fields] OR \"behaviourally\"[All Fields] OR \"behaviours\"[All Fields] OR \"behaviors\"[All Fields] OR \"pattern\"[All Fields] OR \"pattern s\"[All Fields] OR \"patternability\"[All Fields] OR \"patternable\"[All Fields] OR \"patterned\"[All Fields] OR \"patterning\"[All Fields] OR \"patternings\"[All Fields] OR \"patterns\"[All Fields]) OR (\"behavior s\"[All Fields] OR \"behaviorally\"[All Fields] OR \"behaviour\"[All Fields] OR \"behavior\"[MeSH Terms] OR \"behavior\"[All Fields] OR \"behavioural\"[All Fields] OR \"behavioral\"[All Fields] OR \"behaviourally\"[All Fields] OR \"behaviours\"[All Fields] OR \"behaviors\"[All Fields] OR \"pattern\"[All Fields] OR \"pattern s\"[All Fields] OR \"patternability\"[All Fields] OR \"patternable\"[All Fields] OR \"patterned\"[All Fields] OR \"patterning\"[All Fields] OR \"patternings\"[All Fields] OR \"patterns\"[All Fields]) OR \"eating disorder\"[All Fields] OR (\"transit\"[All Fields] OR \"transited\"[All Fields] OR \"transiting\"[All Fields] OR \"transition\"[All Fields] OR \"transitional\"[All Fields] OR \"transitionals\"[All Fields] OR \"transitioned\"[All Fields] OR \"transitioning\"[All Fields] OR \"transitions\"[All Fields] OR \"transits\"[All Fields]) OR \"quality of life\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "guidelines",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (guideline OR consensus OR \"Standards of Care\" OR ISPAD OR NICE OR AACE OR EASD) AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"guideline\"[Publication Type] OR \"guidelines as topic\"[MeSH Terms] OR \"guideline\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR \"Standards of Care\"[All Fields] OR \"ISPAD\"[All Fields] OR \"NICE\"[All Fields] OR \"AACE\"[All Fields] OR \"EASD\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "biomarkers",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (biomarker OR \"C-peptide\" OR autoantibody OR prediction) AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"biomarker s\"[All Fields] OR \"biomarkers\"[Supplementary Concept] OR \"biomarkers\"[All Fields] OR \"biomarker\"[All Fields] OR \"biomarkers\"[MeSH Terms] OR \"C-peptide\"[All Fields] OR (\"autoantibodies\"[Supplementary Concept] OR \"autoantibodies\"[All Fields] OR \"autoantibodies\"[MeSH Terms] OR \"autoantibody\"[All Fields]) OR (\"predict\"[All Fields] OR \"predictabilities\"[All Fields] OR \"predictability\"[All Fields] OR \"predictable\"[All Fields] OR \"predictably\"[All Fields] OR \"predicted\"[All Fields] OR \"predicting\"[All Fields] OR \"prediction\"[All Fields] OR \"predictions\"[All Fields] OR \"predictive\"[All Fields] OR \"predictively\"[All Fields] OR \"predictiveness\"[All Fields] OR \"predictives\"[All Fields] OR \"predictivities\"[All Fields] OR \"predictivity\"[All Fields] OR \"predicts\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "clinical-trials",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (\"clinical trial\" OR randomized OR randomised) AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"clinical trial\"[All Fields] OR (\"random allocation\"[MeSH Terms] OR (\"random\"[All Fields] AND \"allocation\"[All Fields]) OR \"random allocation\"[All Fields] OR \"randomization\"[All Fields] OR \"randomized\"[All Fields] OR \"random\"[All Fields] OR \"randomisation\"[All Fields] OR \"randomisations\"[All Fields] OR \"randomise\"[All Fields] OR \"randomised\"[All Fields] OR \"randomising\"[All Fields] OR \"randomizations\"[All Fields] OR \"randomize\"[All Fields] OR \"randomizes\"[All Fields] OR \"randomizing\"[All Fields] OR \"randomness\"[All Fields] OR \"randoms\"[All Fields]) OR (\"random allocation\"[MeSH Terms] OR (\"random\"[All Fields] AND \"allocation\"[All Fields]) OR \"random allocation\"[All Fields] OR \"randomization\"[All Fields] OR \"randomized\"[All Fields] OR \"random\"[All Fields] OR \"randomisation\"[All Fields] OR \"randomisations\"[All Fields] OR \"randomise\"[All Fields] OR \"randomised\"[All Fields] OR \"randomising\"[All Fields] OR \"randomizations\"[All Fields] OR \"randomize\"[All Fields] OR \"randomizes\"[All Fields] OR \"randomizing\"[All Fields] OR \"randomness\"[All Fields] OR \"randoms\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "patient-experience",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (\"patient experience\" OR qualitative OR advocacy OR access OR stigma) AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"patient experience\"[All Fields] OR (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields]) OR (\"advocacies\"[All Fields] OR \"advocacy\"[All Fields] OR \"advocacy s\"[All Fields]) OR (\"access\"[All Fields] OR \"accessed\"[All Fields] OR \"accesses\"[All Fields] OR \"accessibilities\"[All Fields] OR \"accessibility\"[All Fields] OR \"accessible\"[All Fields] OR \"accessing\"[All Fields]) OR (\"social stigma\"[MeSH Terms] OR (\"social\"[All Fields] AND \"stigma\"[All Fields]) OR \"social stigma\"[All Fields] OR \"stigma\"[All Fields] OR \"stigmas\"[All Fields] OR \"stigma s\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  },
  {
   "source": "cochrane-via-pubmed",
   "topic": "safety",
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (ketoacidosis OR safety OR \"adverse event\" OR SGLT OR driving OR exercise) AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND (\"ketosis\"[MeSH Terms] OR \"ketosis\"[All Fields] OR \"ketoacidosis\"[All Fields] OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]) OR \"adverse event\"[All Fields] OR \"SGLT\"[All Fields] OR (\"automobile driving\"[MeSH Terms] OR (\"automobile\"[All Fields] AND \"driving\"[All Fields]) OR \"automobile driving\"[All Fields] OR \"driving\"[All Fields] OR \"drive\"[MeSH Terms] OR \"drive\"[All Fields] OR \"drives\"[All Fields] OR \"drivings\"[All Fields]) OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": []
  }
 ],
 "supplemental_pubmed": [
  {
   "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract]) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 0,
   "ids": [],
   "topic": "cdsr-condition-wide"
  },
  {
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp]) AND (guideline[pt] OR \"practice guideline\"[pt] OR \"systematic review\"[pt] OR \"meta-analysis\"[pt] OR \"randomized controlled trial\"[pt] OR \"clinical trial\"[pt] OR \"consensus development conference\"[pt])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND 2026/08/28:2026/10/29[Date - Publication] AND (\"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"systematic review\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"randomized controlled trial\"[Publication Type] OR \"clinical trial\"[Publication Type])",
   "count": 68,
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   "topic": "high-signal-pt"
  },
  {
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp]) AND (\"Retracted Publication\"[pt] OR \"Expression of Concern\"[pt])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND 2026/08/28:2026/10/29[Date - Publication] AND (\"Retracted Publication\"[Publication Type] OR \"Expression of Concern\"[Publication Type])",
   "count": 0,
   "ids": [],
   "topic": "retractions-dp"
  },
  {
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (\"2026/10/23\"[edat] : \"2026/10/29\"[edat]) AND (\"Retracted Publication\"[pt] OR \"Expression of Concern\"[pt] OR \"Retraction of Publication\"[pt])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND 2026/10/23:2026/10/29[Date - Entry] AND (\"Retracted Publication\"[Publication Type] OR \"Expression of Concern\"[Publication Type])",
   "count": 0,
   "ids": [],
   "topic": "retractions-edat"
  },
  {
   "query": "(\"Diabetes Mellitus, Type 1\"[Mesh] OR \"type 1 diabetes\"[tiab] OR \"type 1 diabetic\"[tiab]) AND (\"2026/10/23\"[edat] : \"2026/10/29\"[edat]) AND (\"2026/08/28\"[dp] : \"3000\"[dp])",
   "translation": "(\"diabetes mellitus, type 1\"[MeSH Terms] OR \"type 1 diabetes\"[Title/Abstract] OR \"type 1 diabetic\"[Title/Abstract]) AND 2026/10/23:2026/10/29[Date - Entry] AND 2026/08/28:3000/12/31[Date - Publication]",
   "count": 87,
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    "42909882",
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    "42909321",
    "42909265",
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    "42908659",
    "42908608"
   ],
   "topic": "newly-indexed-in-window"
  },
  {
   "query": "(ISPAD[ti] OR \"Standards of Care in Diabetes\"[ti] OR \"consensus statement\"[ti] OR \"consensus report\"[ti] OR \"clinical practice guideline\"[ti]) AND (diabetes[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "(\"ISPAD\"[Title] OR \"consensus statement\"[Title] OR \"consensus report\"[Title] OR \"clinical practice guideline\"[Title]) AND \"diabetes\"[Title/Abstract] AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 15,
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    "42747450",
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    "42734653",
    "42734244",
    "42709002",
    "42692169"
   ],
   "topic": "ispad-ada-update"
  },
  {
   "query": "\"Cochrane Database Syst Rev\"[jour] AND (diabetes[tiab] OR insulin[tiab] OR hypoglycaemia[tiab] OR hypoglycemia[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/29\"[dp])",
   "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"diabetes\"[Title/Abstract] OR \"insulin\"[Title/Abstract] OR \"hypoglycaemia\"[Title/Abstract] OR \"hypoglycemia\"[Title/Abstract]) AND 2026/08/28:2026/10/29[Date - Publication]",
   "count": 1,
   "ids": [
    "42788405"
   ],
   "topic": "cdsr-diabetes-broad"
  }
 ],
 "cochrane_note": "All 16 topic CDSR queries and the condition-wide CDSR query returned 0. A broader diabetes CDSR query returned 1 record, PMID 42788405 (Larvie 2026, 'Blood pressure targets for hypertension in people with diabetes mellitus'), which is a protocol for a review with no results; it does not supersede or contradict any claim here. CENTRAL not searched (cochranelibrary.com HTTP 403).",
 "bibliography_retraction_batches": [
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   "title": "Maternal Autoimmune Diseases During Pregnancy and Offspring Type 1 Diabetes.",
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    "title": "Population‐Based Screening for Type 1 Diabetes in Czechia: Results From the First 1% of th"
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   "title": "Population-Based Screening for Type 1 Diabetes in Czechia: Results From the First 1% of the Paediatric Population.",
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   "check": "ISPAD",
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   "check": "NICE NG17/NG18/TA1176",
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