{ "retrieved_on": "2026-09-30", "condition": "thoracic-aortic-aneurysm", "author": "Codex", "publication_window": { "from": "2026-08-31", "through": "2026-09-30", "inclusive": true, "date_type": "pdat" }, "pubmed_endpoints": [ "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi", "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi" ], "searches": { "all_thoracic": { "parameters": { "db": "pubmed", "term": "\"aortic aneurysm, thoracic\"[MeSH Terms] OR (thoracic[Title/Abstract] AND aortic[Title/Abstract] AND aneurysm*[Title/Abstract])", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 91, "translated_query": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR (\"thoracic\"[Title/Abstract] AND \"aortic\"[Title/Abstract] AND \"aneurysm*\"[Title/Abstract])) AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42805273", "42803214", "42799237", "42794678", "42790905", "42790271", "42787211", "42784427", "42780647", "42777112", "42773497", "42768306", "42762683", "42762216", "42761954", "42761108", "42760670", "42760095", "42755965", "42755723", "42754219", "42752781", "42751870", "42750854", "42750146", "42746227", "42744127", "42741076", "42735960", "42735959", "42735958", "42735956", "42735953", "42734998", "42724656", "42724486", "42724301", "42722267", "42722264", "42722197", "42710832", "42708483", "42705374", "42704441", "42702804", "42700319", "42697566", "42696310", "42688651", "42685200", "42683959", "42678485", "42678067", "42674098", "42593274", "42561585", "42545482", "42527266", "42506939", "42506925", "42480780", "42446466", "42364561", "42323238", "42283670", "42283085", "42266042", "42250598", "42215397", "42215388", "42190970", "42128131", "42119758", "42103141", "42103139", "42103136", "42086160", "42083064", "42082039", "42055302", "42053472", "42011731", "41949160", "41935738", "41894096", "41819247", "41655633", "41627038", "41581749", "41539593", "40643772" ] }, "epidemiology": { "parameters": { "db": "pubmed", "term": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR aortopathy[Title/Abstract] OR aortopathies[Title/Abstract]) AND (epidemiology OR incidence OR prevalence OR growth OR natural history OR registry OR burden OR mortality)", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 114, "translated_query": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR \"aortopathy\"[Title/Abstract] OR \"aortopathies\"[Title/Abstract]) AND (\"epidemiologies\"[All Fields] OR \"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"epidemiology\"[MeSH Terms] OR \"epidemiology s\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields]) OR (\"growth and development\"[MeSH Subheading] OR (\"growth\"[All Fields] AND \"development\"[All Fields]) OR \"growth and development\"[All Fields] OR \"growth\"[All Fields] OR \"growth\"[MeSH Terms] OR \"growths\"[All Fields]) OR (\"natural history\"[MeSH Terms] OR (\"natural\"[All Fields] AND \"history\"[All Fields]) OR \"natural history\"[All Fields]) OR (\"registries\"[MeSH Terms] OR \"registries\"[All Fields] OR \"registry\"[All Fields] OR \"registry s\"[All Fields]) OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading])) AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42814054", "42810709", "42808436", "42806353", "42806093", "42805273", "42803214", "42794678", "42792802", "42789747", "42786732", "42785369", "42783440", "42783052", "42780583", "42780433", "42773928", "42768306", "42766226", "42764722", "42761954", "42761108", "42760095", "42758426", "42757002", "42756735", "42756438", "42755965", "42754184", "42752801", "42752795", "42752781", "42750854", "42749231", "42745983", "42745167", "42744127", "42742085", "42741187", "42739831", "42739242", "42735974", "42735961", "42735958", "42735956", "42735953", "42735951", "42735948", "42734858", "42724524", "42724517", "42724301", "42722729", "42722539", "42722267", "42720823", "42719662", "42719621", "42716262", "42714430", "42711262", "42710829", "42710196", "42707265", "42705504", "42704441", "42702206", "42701023", "42697313", "42696310", "42693914", "42693683", "42689446", "42683959", "42678067", "42675665", "34662092", "42670210", "42665038", "42633938", "42593274", "42532706", "42527266", "42489613", "42473603", "42448851", "42446466", "42438739", "42431105", "42386011", "42364561", "42330609", "42307107", "42283700", "42283670", "42283085", "42266042", "42250598", "42229204", "42215388", "42190970", "42128131", "42119758", "42103141", "42086160", "42083064", "42082039", "42053472", "41935738", "41875997", "41787887", "41655633", "41654180", "41539593" ] }, "genetics_syndromes": { "parameters": { "db": "pubmed", "term": "(Marfan OR Loeys-Dietz OR vascular Ehlers-Danlos OR Turner OR (\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR aortopathy[Title/Abstract] OR aortopathies[Title/Abstract])) AND (aort* AND (genetic* OR heritable OR variant OR syndrome OR screening))", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 130, "translated_query": "(\"marfan\"[All Fields] OR \"marfan s\"[All Fields] OR \"marfans\"[All Fields] OR \"Loeys-Dietz\"[All Fields] OR ((\"blood vessels\"[MeSH Terms] OR (\"blood\"[All Fields] AND \"vessels\"[All Fields]) OR \"blood vessels\"[All Fields] OR \"vascular\"[All Fields] OR \"vascularisation\"[All Fields] OR \"neovascularization, pathologic\"[MeSH Terms] OR (\"neovascularization\"[All Fields] AND \"pathologic\"[All Fields]) OR \"pathologic neovascularization\"[All Fields] OR \"vascularization\"[All Fields] OR \"vascularisations\"[All Fields] OR \"vascularise\"[All Fields] OR \"vascularised\"[All Fields] OR \"vascularities\"[All Fields] OR \"vascularitis\"[All Fields] OR \"vascularity\"[All Fields] OR \"vascularizations\"[All Fields] OR \"vascularize\"[All Fields] OR \"vascularized\"[All Fields] OR \"vascularizes\"[All Fields] OR \"vascularizing\"[All Fields] OR \"vasculars\"[All Fields]) AND \"Ehlers-Danlos\"[All Fields]) OR (\"turner\"[All Fields] OR \"turner s\"[All Fields] OR \"turners\"[All Fields]) OR (\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR \"aortopathy\"[Title/Abstract] OR \"aortopathies\"[Title/Abstract])) AND (\"aort*\"[All Fields] AND (\"genetic*\"[All Fields] OR (\"heritabilities\"[All Fields] OR \"heritability\"[All Fields] OR \"heritable\"[All Fields] OR \"heritably\"[All Fields]) OR (\"variant\"[All Fields] OR \"variant s\"[All Fields] OR \"variants\"[All Fields]) OR (\"syndrom\"[All Fields] OR \"syndromal\"[All Fields] OR \"syndromally\"[All Fields] OR \"syndrome\"[MeSH Terms] OR \"syndrome\"[All Fields] OR \"syndromes\"[All Fields] OR \"syndrome s\"[All Fields] OR \"syndromic\"[All Fields] OR \"syndroms\"[All Fields]) OR (\"diagnosis\"[MeSH Subheading] OR \"diagnosis\"[All Fields] OR \"screening\"[All Fields] OR \"mass screening\"[MeSH Terms] OR (\"mass\"[All Fields] AND \"screening\"[All Fields]) OR \"mass screening\"[All Fields] OR \"early detection of cancer\"[MeSH Terms] OR (\"early\"[All Fields] AND \"detection\"[All Fields] AND \"cancer\"[All Fields]) OR \"early detection of cancer\"[All Fields] OR \"screen\"[All Fields] OR \"screenings\"[All Fields] OR \"screened\"[All Fields] OR \"screens\"[All Fields]))) AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42814054", "42813845", "42812842", "42803733", "42795938", "42794678", "42783440", "42783052", "42773928", "42768306", "42761954", "42761146", "42760744", "42760670", "42760095", "42757899", "42757002", "42755424", "42755320", "42752801", "42751128", "42751106", "42750854", "42749231", "42747764", "42747000", "42743781", "42742085", "42741187", "42735974", "42735961", "42735960", "42735959", "42735958", "42735956", 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"41943504", "41935738", "41916683", "41819247", "41655633", "41627038", "41581749", "41539593", "41531143", "41429339", "40643772", "40454880" ] }, "bicuspid": { "parameters": { "db": "pubmed", "term": "(bicuspid aortic valve) AND (aortopathy OR aneurysm OR dilation OR dilatation)", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 21, "translated_query": "(\"bicuspid aortic valve disease\"[MeSH Terms] OR (\"bicuspid\"[All Fields] AND \"aortic\"[All Fields] AND \"valve\"[All Fields] AND \"disease\"[All Fields]) OR \"bicuspid aortic valve disease\"[All Fields] OR (\"bicuspid\"[All Fields] AND \"aortic\"[All Fields] AND \"valve\"[All Fields]) OR \"bicuspid aortic valve\"[All Fields]) AND (\"aortopathies\"[All Fields] OR \"aortopathy\"[All Fields] OR (\"aneurysm\"[MeSH Terms] OR \"aneurysm\"[All Fields] OR \"aneurysms\"[All Fields] OR \"aneurysm s\"[All Fields] OR \"aneurysmal\"[All Fields] OR \"aneurysmally\"[All Fields] OR \"aneurysmic\"[All Fields]) OR (\"dilatable\"[All Fields] OR \"dilatated\"[All Fields] OR \"dilatating\"[All Fields] OR \"dilatation\"[MeSH Terms] OR \"dilatation\"[All Fields] OR \"dilatations\"[All Fields] OR \"dilate\"[All Fields] OR \"dilation\"[All Fields] OR \"dilations\"[All Fields] OR \"dilatative\"[All Fields] OR \"dilatator\"[All Fields] OR \"dilatators\"[All Fields] OR \"dilated\"[All Fields] OR \"dilates\"[All Fields] OR \"dilating\"[All Fields] OR \"dilator\"[All Fields] OR \"dilators\"[All Fields]) OR (\"dilatable\"[All Fields] OR \"dilatated\"[All Fields] OR \"dilatating\"[All Fields] OR \"dilatation\"[MeSH Terms] OR \"dilatation\"[All Fields] OR \"dilatations\"[All Fields] OR \"dilate\"[All Fields] OR \"dilation\"[All Fields] OR \"dilations\"[All Fields] OR \"dilatative\"[All Fields] OR \"dilatator\"[All Fields] OR \"dilatators\"[All Fields] OR \"dilated\"[All Fields] OR \"dilates\"[All Fields] OR \"dilating\"[All Fields] OR \"dilator\"[All Fields] OR \"dilators\"[All Fields])) AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42801971", "42799237", "42794678", "42790905", "42783440", "42739831", "42739242", "42733126", "42726041", "42722264", "42716726", "42705374", "42693699", "42691142", "42687335", "42684229", "42670210", "42549846", "42506925", "42266042", "41787887" ] }, "mechanisms_models_omics": { "parameters": { "db": "pubmed", "term": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR aortopathy[Title/Abstract] OR aortopathies[Title/Abstract]) AND (mechanism OR inflammation OR smooth muscle OR extracellular matrix OR TGF OR mouse OR mice OR animal model OR transcriptom* OR proteom* OR single-cell OR GWAS)", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 46, "translated_query": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR \"aortopathy\"[Title/Abstract] OR \"aortopathies\"[Title/Abstract]) AND (\"mechanism\"[All Fields] OR \"mechanisms\"[All Fields] OR (\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation s\"[All Fields]) OR (\"muscle, smooth\"[MeSH Terms] OR (\"muscle\"[All Fields] AND \"smooth\"[All Fields]) OR \"smooth muscle\"[All Fields] OR (\"smooth\"[All Fields] AND \"muscle\"[All Fields])) OR (\"extracellular matrix\"[MeSH Terms] OR (\"extracellular\"[All Fields] AND \"matrix\"[All Fields]) OR \"extracellular matrix\"[All Fields]) OR \"TGF\"[All Fields] OR (\"mice\"[MeSH Terms] OR \"mice\"[All Fields] OR \"mouse\"[All Fields] OR \"mouse s\"[All Fields] OR \"mouses\"[All Fields]) OR (\"mice\"[MeSH Terms] OR \"mice\"[All Fields]) OR (\"models, animal\"[MeSH Terms] OR (\"models\"[All Fields] AND \"animal\"[All Fields]) OR \"animal models\"[All Fields] OR (\"animal\"[All Fields] AND \"model\"[All Fields]) OR \"animal model\"[All Fields]) OR \"transcriptom*\"[All Fields] OR \"proteom*\"[All Fields] OR \"single-cell\"[All Fields] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields])) AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42803733", "42794678", "42792802", "42790271", "42789978", "42786635", "42783440", "42783049", "42773990", "42766226", "42762683", "42761954", "42755965", "42755320", "42752801", "42752795", "42750854", "42749231", "42747764", "42741187", "42739242", "42738917", "42735950", "42724301", "42720823", "42710196", "42707265", "42693914", "42685200", "42683679", "42678949", "42678067", "42489613", "42431105", "42364561", "42341612", "42307107", "42287300", "42250598", "42229204", "42011731", "41654180", "41581749", "41531143", "40643772", "40454880" ] }, "imaging_biomechanics": { "parameters": { "db": "pubmed", "term": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR aortopathy[Title/Abstract] OR aortopathies[Title/Abstract]) AND (imaging OR surveillance OR magnetic resonance OR computed tomography OR echocardiography OR biomechanics OR wall stress OR flow OR measurement)", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 141, "translated_query": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR \"aortopathy\"[Title/Abstract] OR \"aortopathies\"[Title/Abstract]) AND (\"image s\"[All Fields] OR \"imaged\"[All Fields] OR \"imager\"[All Fields] OR \"imager s\"[All Fields] OR \"imagers\"[All Fields] OR \"images\"[All Fields] OR \"imaging\"[All Fields] OR \"imaging s\"[All Fields] OR \"imagings\"[All Fields] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[Supplementary Concept] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[All Fields] OR \"image\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"surveillance\"[All Fields] OR \"epidemiology\"[MeSH Terms] OR \"surveilance\"[All Fields] OR \"surveillances\"[All Fields] OR \"surveilled\"[All Fields] OR \"surveillence\"[All Fields]) OR (\"magnetic resonance spectroscopy\"[MeSH Terms] OR (\"magnetic\"[All Fields] AND \"resonance\"[All Fields] AND \"spectroscopy\"[All Fields]) OR \"magnetic resonance spectroscopy\"[All Fields] OR (\"magnetic\"[All Fields] AND \"resonance\"[All Fields]) OR \"magnetic resonance\"[All Fields]) OR (\"tomography, x ray computed\"[MeSH Terms] OR (\"tomography\"[All Fields] AND \"x ray\"[All Fields] AND \"computed\"[All Fields]) OR \"x-ray computed tomography\"[All Fields] OR (\"computed\"[All Fields] AND \"tomography\"[All Fields]) OR \"computed tomography\"[All Fields]) OR (\"echocardiographies\"[All Fields] OR \"echocardiography\"[MeSH Terms] OR \"echocardiography\"[All Fields]) OR (\"biomechanical phenomena\"[MeSH Terms] OR (\"biomechanical\"[All Fields] AND \"phenomena\"[All Fields]) OR \"biomechanical phenomena\"[All Fields] OR \"biomechanic\"[All Fields] OR \"biomechanics\"[All Fields] OR \"biomechanical\"[All Fields] OR \"biomechanically\"[All Fields]) OR (\"wall\"[All Fields] AND (\"stress\"[All Fields] OR \"stressed\"[All Fields] OR \"stresses\"[All Fields] OR \"stressful\"[All Fields] OR \"stressfulness\"[All Fields] OR \"stressing\"[All Fields])) OR (\"flow camb\"[Journal] OR \"flow\"[All Fields]) OR (\"measurability\"[All Fields] OR \"measurable\"[All Fields] OR \"measurably\"[All Fields] OR \"measure s\"[All Fields] OR \"measureable\"[All Fields] OR \"measured\"[All Fields] OR \"measurement\"[All Fields] OR \"measurement s\"[All Fields] OR \"measurements\"[All Fields] OR \"measurer\"[All Fields] OR \"measurers\"[All Fields] OR \"measuring\"[All Fields] OR \"measurings\"[All Fields] OR \"measurment\"[All Fields] OR \"measurments\"[All Fields] OR \"weights and measures\"[MeSH Terms] OR (\"weights\"[All Fields] AND \"measures\"[All Fields]) OR \"weights and measures\"[All Fields] OR \"measure\"[All Fields] OR \"measures\"[All Fields])) AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42813845", "42811763", "42808436", "42803733", "42800668", "42799237", "42795938", "42794678", "42792802", "42791477", "42790905", "42789978", "42789747", "42786635", "42784031", "42783440", "42783052", "42783033", "42768306", "42767855", "42765415", "42765414", "42764722", "42762216", "42761954", "42761146", "42760744", "42760670", "42760095", "42758426", "42757899", "42757002", "42756735", "42755722", "42755320", "42754009", "42752801", "42752795", "42752716", "42751106", "42747000", "42746129", "42745983", "42745167", "42742085", "42739831", "42739242", "42738917", "42735974", "42735961", "42735960", "42735959", "42735958", "42735956", "42735953", "42735951", "42735950", "42735948", "42734998", "42734858", "42731460", "42731181", "42728840", "42724681", "42724656", "42722539", "42722267", "42722055", "42720823", "42720655", "42719662", "42719655", "42719639", "42719069", "42714430", "42711262", "42710196", "42708624", "42707265", "42705523", "42705374", "42704441", "42700319", "42699956", "42699175", "42699056", "42697566", "42693914", "42689446", "42688651", "42683679", "42676858", "42675665", "42671366", "42670210", "42633938", "42593274", "42561585", "42560828", "42545482", "42532706", "42527266", "42506939", "42506925", "42489613", "42480780", "42448851", "42446466", "42423567", "42386011", "42381745", "42360268", "42348726", "42330609", "42287300", "42283085", "42266042", "42250598", "42190970", "42171944", "42165574", "42128131", "42119758", "42103141", "42103139", "42103136", "42086160", "42083064", "42082039", "42055302", "42053472", "41949160", "41943504", "41935738", "41875997", "41655633", "41654180", "41627038", "41581749", "41539593", "41531143" ] }, "risk_biomarkers": { "parameters": { "db": "pubmed", "term": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR aortopathy[Title/Abstract] OR aortopathies[Title/Abstract]) AND (risk prediction OR risk stratification OR threshold OR diameter OR biomarker OR microRNA)", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 75, "translated_query": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR \"aortopathy\"[Title/Abstract] OR \"aortopathies\"[Title/Abstract]) AND (((\"risk\"[MeSH Terms] OR \"risk\"[All Fields]) AND (\"predict\"[All Fields] OR \"predictabilities\"[All Fields] OR \"predictability\"[All Fields] OR \"predictable\"[All Fields] OR \"predictably\"[All Fields] OR \"predicted\"[All Fields] OR \"predicting\"[All Fields] OR \"prediction\"[All Fields] OR \"predictions\"[All Fields] OR \"predictive\"[All Fields] OR \"predictively\"[All Fields] OR \"predictiveness\"[All Fields] OR \"predictives\"[All Fields] OR \"predictivities\"[All Fields] OR \"predictivity\"[All Fields] OR \"predicts\"[All Fields])) OR ((\"risk\"[MeSH Terms] OR \"risk\"[All Fields]) AND (\"stratification\"[All Fields] OR \"stratifications\"[All Fields])) OR (\"threshold\"[All Fields] OR \"thresholds\"[All Fields]) OR (\"diameter\"[All Fields] OR \"diameters\"[All Fields]) OR (\"biomarker s\"[All Fields] OR \"biomarkers\"[Supplementary Concept] OR \"biomarkers\"[All Fields] OR \"biomarker\"[All Fields] OR \"biomarkers\"[MeSH Terms]) OR (\"microrna s\"[All Fields] OR \"micrornas\"[Supplementary Concept] OR \"micrornas\"[All Fields] OR \"microrna\"[All Fields] OR \"micrornas\"[MeSH Terms])) AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42806093", "42799237", "42794678", "42789747", "42784427", "42783440", "42783052", "42783049", "42783033", "42780583", "42768306", "42765415", "42761954", "42761146", "42760670", "42760095", "42758426", "42757949", "42757002", "42756735", "42756438", "42750854", "42747764", "42745167", "42742085", "42739242", "42735961", "42735960", "42735958", "42735948", "42734858", "42731181", "42724681", "42722539", "42722264", "42719662", "42719639", "42708624", "42704441", "42702206", "42689446", "42688651", "42678067", "42675665", "34662092", "42671366", "42670210", "42532706", "42527266", "42489613", "42480780", "42473603", "42448851", "42446466", "42438739", "42431105", "42386011", "42341612", "42330609", "42283700", "42283085", "42215397", "42103141", "42103139", "42082039", "42053472", "42011731", "41935738", "41894096", "41875997", "41654180", "41581749", "41539593", "41429339", "40643772" ] }, "medical_exercise_safety": { "parameters": { "db": "pubmed", "term": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR aortopathy[Title/Abstract] OR aortopathies[Title/Abstract]) AND (drug OR therapy OR losartan OR beta-blocker OR angiotensin OR exercise OR pregnancy OR fluoroquinolone)", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 96, "translated_query": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR \"aortopathy\"[Title/Abstract] OR \"aortopathies\"[Title/Abstract]) AND (\"drug\"[All Fields] OR (\"therapeutics\"[MeSH Terms] OR \"therapeutics\"[All Fields] OR \"therapies\"[All Fields] OR \"therapy\"[MeSH Subheading] OR \"therapy\"[All Fields] OR \"therapy s\"[All Fields] OR \"therapys\"[All Fields]) OR (\"losartan\"[Supplementary Concept] OR \"losartan\"[All Fields] OR \"losartan\"[MeSH Terms] OR \"losartan s\"[All Fields] OR \"losartane\"[All Fields]) OR (\"adrenergic beta antagonists\"[Pharmacological Action] OR \"adrenergic beta antagonists\"[Supplementary Concept] OR \"adrenergic beta antagonists\"[All Fields] OR \"beta blocker\"[All Fields] OR \"adrenergic beta antagonists\"[MeSH Terms] OR (\"adrenergic\"[All Fields] AND \"beta antagonists\"[All Fields]) OR (\"beta\"[All Fields] AND \"blocker\"[All Fields])) OR (\"angiotensin s\"[All Fields] OR \"angiotensine\"[All Fields] OR \"angiotensins\"[Supplementary Concept] OR \"angiotensins\"[All Fields] OR \"angiotensin\"[All Fields] OR \"angiotensins\"[MeSH Terms]) OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]) OR (\"pregnancy\"[MeSH Terms] OR \"pregnancy\"[All Fields] OR \"pregnancies\"[All Fields] OR \"pregnancy s\"[All Fields]) OR (\"fluoroquinolon\"[All Fields] OR \"fluoroquinolones\"[Supplementary Concept] OR \"fluoroquinolones\"[All Fields] OR \"fluoroquinolone\"[All Fields] OR \"fluoroquinolones\"[MeSH Terms] OR \"fluoroquinolonic\"[All Fields] OR \"fluoroquinolons\"[All Fields])) AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42814054", "42810709", "42805273", "42803214", "42800668", "42799237", "42795928", "42794678", "42790271", "42789978", "42786635", "42785369", "42783052", "42768306", "42767855", "42766226", "42762216", "42760744", "42758426", "42755320", "42752801", "42752795", "42746129", "42745167", "42742085", "42741187", "42738917", "42735974", "42735960", "42735959", "42735958", "42735956", "42735953", "42735951", "42735950", "42735948", "42734998", "42734858", "42724656", "42724301", "42722055", "42720823", "42710829", "42708624", "42705523", "42704441", "42699175", "42697566", "42696310", "42693914", "42689446", "42689234", "42683959", "42683679", "42678949", "34662092", "42593274", "42545482", "42532706", "42506939", "42506925", "42431105", "42423567", "42364561", "42363924", "42360268", "42348726", "42341612", "42330609", "42307107", "42287300", "42283700", "42283085", "42266042", "42250598", "42229204", "42190970", "42165574", "42128131", "42119758", "42103141", "42103139", "42103136", "42082039", "42055302", "42053472", "41949160", "41894096", "41819247", "41787887", "41774035", "41627038", "41581749", "41539593", "41531143", "40643772" ] }, "surgery_devices": { "parameters": { "db": "pubmed", "term": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR aortopathy[Title/Abstract] OR aortopathies[Title/Abstract]) AND (surgery OR surgical OR endovascular OR TEVAR OR valve-sparing OR stent OR repair)", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 192, "translated_query": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR \"aortopathy\"[Title/Abstract] OR \"aortopathies\"[Title/Abstract]) AND (\"surgery\"[MeSH Subheading] OR \"surgery\"[All Fields] OR \"surgical procedures, operative\"[MeSH Terms] OR (\"surgical\"[All Fields] AND \"procedures\"[All Fields] AND \"operative\"[All Fields]) OR \"operative surgical procedures\"[All Fields] OR \"general surgery\"[MeSH Terms] OR (\"general\"[All Fields] AND \"surgery\"[All Fields]) OR \"general surgery\"[All Fields] OR \"surgery s\"[All Fields] OR \"surgerys\"[All Fields] OR \"surgeries\"[All Fields] OR (\"surgical procedures, operative\"[MeSH Terms] OR (\"surgical\"[All Fields] AND \"procedures\"[All Fields] AND \"operative\"[All Fields]) OR \"operative surgical procedures\"[All Fields] OR \"surgical\"[All Fields] OR \"surgically\"[All Fields] OR \"surgicals\"[All Fields]) OR \"endovascular\"[All Fields] OR (\"endovascular aneurysm repair\"[MeSH Terms] OR (\"endovascular\"[All Fields] AND \"aneurysm\"[All Fields] AND \"repair\"[All Fields]) OR \"endovascular aneurysm repair\"[All Fields] OR \"tevar\"[All Fields] OR \"tevars\"[All Fields]) OR \"valve-sparing\"[All Fields] OR (\"stent s\"[All Fields] OR \"stentings\"[All Fields] OR \"stents\"[MeSH Terms] OR \"stents\"[All Fields] OR \"stent\"[All Fields] OR \"stented\"[All Fields] OR \"stenting\"[All Fields]) OR (\"repairability\"[All Fields] OR \"repairable\"[All Fields] OR \"repaire\"[All Fields] OR \"repaired\"[All Fields] OR \"repairment\"[All Fields] OR \"wound healing\"[MeSH Terms] OR (\"wound\"[All Fields] AND \"healing\"[All Fields]) OR \"wound healing\"[All Fields] OR \"repair\"[All Fields] OR \"repairing\"[All Fields] OR \"repairs\"[All Fields])) AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42814054", "42813845", "42812842", "42811763", "42810709", "42808436", "42806093", "42805273", "42803214", "42800668", "42799237", "42795928", "42794678", "42792802", "42791477", "42790905", "42790271", "42789747", "42789220", "42786732", "42786635", "42785369", "42784427", "42784031", "42783049", "42783033", "42781267", "42780433", "42774760", "42773990", "42773928", "42767855", "42765415", "42765414", "42764722", "42762683", "42762216", "42761954", "42761146", "42761108", "42760744", "42760670", "42759796", "42758426", "42757899", "42756438", "42755722", "42755320", "42754184", "42754009", "42752801", "42752781", "42752716", "42751386", "42751106", "42750854", "42749231", "42747764", 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"42446466", "42438739", "42431105", "42423567", "42381745", "42364561", "42363924", "42360268", "42341612", "42330609", "42307107", "42283700", "42283670", "42283085", "42266042", "42250598", "42229204", "42215397", "42215388", "42190970", "42171944", "42165574", "42159927", "42128131", "42119758", "42107696", "42107648", "42103141", "42103139", "42103136", "42086160", "42083064", "42082039", "42055302", "42011731", "41949160", "41894096", "41875997", "41819247", "41787887", "41655633", "41627038", "41581749", "41539593", "41482023", "41478333", "41429339", "41275999", "41265739", "40643772", "40454880" ] }, "dissection": { "parameters": { "db": "pubmed", "term": "\"aortic dissection\"[Title/Abstract]", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 134, "translated_query": "\"aortic dissection\"[Title/Abstract] AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42814054", "42812842", "42811763", "42810709", "42808436", "42806353", "42806093", "42805273", "42800668", "42795928", "42792802", "42789747", "42789220", "42786635", "42785369", "42784031", "42783049", "42781267", "42780583", "42780433", "42774760", "42773990", "42768306", "42767855", "42766226", "42765415", "42764722", "42761146", "42760744", "42759796", "42758426", "42757949", "42757899", "42757002", "42756438", "42755965", "42755722", "42754009", "42752716", "42749231", "42747000", "42746901", "42746129", "42745167", "42744127", "42741187", "42738917", "42735961", "42735960", "42735948", "42730739", "42724681", "42724524", "42724517", "42724486", "42722539", "42722267", "42720823", "42720655", "42719662", "42719655", "42719639", "42719621", "42719584", "42714430", "42711262", "42710829", "42710196", "42708624", "42707265", "42705526", "42705523", "42705504", "42704441", "42702206", "42701023", "42699175", "42699056", "42697566", "42696310", "42693914", "42693683", "42690230", "42689446", "42689234", "42688651", "42683679", "42678949", "42678067", "42676858", "42675665", "42671366", "42665038", "42633938", "42558828", "42545482", "42527266", "42489613", "42473603", "42448851", "42438739", "42431105", "42423567", "42363924", "42348726", "42341612", "42330609", "42307107", "42283700", "42283085", "42266042", "42229204", "42215397", "42171944", "42165574", "42159927", "42107696", "42107648", "42103141", "42103139", "42086160", "42083064", "42082039", "41894096", "41875997", "41774035", "41655633", "41654180", "41539593", "41531143", "41482023", "41478333", "41275999", "41265739" ] }, "guidelines": { "parameters": { "db": "pubmed", "term": "(aort* OR Marfan OR Loeys-Dietz OR vascular Ehlers-Danlos OR Turner) AND (guideline OR consensus OR scientific statement OR position statement OR Ghent)", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 90, "translated_query": "(\"aort*\"[All Fields] OR (\"marfan\"[All Fields] OR \"marfan s\"[All Fields] OR \"marfans\"[All Fields]) OR \"Loeys-Dietz\"[All Fields] OR ((\"blood vessels\"[MeSH Terms] OR (\"blood\"[All Fields] AND \"vessels\"[All Fields]) OR \"blood vessels\"[All Fields] OR \"vascular\"[All Fields] OR \"vascularisation\"[All Fields] OR \"neovascularization, pathologic\"[MeSH Terms] OR (\"neovascularization\"[All Fields] AND \"pathologic\"[All Fields]) OR \"pathologic neovascularization\"[All Fields] OR \"vascularization\"[All Fields] OR \"vascularisations\"[All Fields] OR \"vascularise\"[All Fields] OR \"vascularised\"[All Fields] OR \"vascularities\"[All Fields] OR \"vascularitis\"[All Fields] OR \"vascularity\"[All Fields] OR \"vascularizations\"[All Fields] OR \"vascularize\"[All Fields] OR \"vascularized\"[All Fields] OR \"vascularizes\"[All Fields] OR \"vascularizing\"[All Fields] OR \"vasculars\"[All Fields]) AND \"Ehlers-Danlos\"[All Fields]) OR (\"turner\"[All Fields] OR \"turner s\"[All Fields] OR \"turners\"[All Fields])) AND (\"guideline\"[Publication Type] OR \"guidelines as topic\"[MeSH Terms] OR \"guideline\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR ((\"science\"[MeSH Terms] OR \"science\"[All Fields] OR \"scientific\"[All Fields] OR \"scientifical\"[All Fields] OR \"scientifically\"[All Fields] OR \"scientification\"[All Fields] OR \"scientificity\"[All Fields] OR \"scientifics\"[All Fields]) AND (\"statement\"[All Fields] OR \"statement s\"[All Fields] OR \"statements\"[All Fields])) OR ((\"patient positioning\"[MeSH Terms] OR (\"patient\"[All Fields] AND \"positioning\"[All Fields]) OR \"patient positioning\"[All Fields] OR \"positioning\"[All Fields] OR \"position\"[All Fields] OR \"position s\"[All Fields] OR \"positional\"[All Fields] OR \"positioned\"[All Fields] OR \"positionings\"[All Fields] OR \"positions\"[All Fields]) AND (\"statement\"[All Fields] OR \"statement s\"[All Fields] OR \"statements\"[All Fields])) OR \"Ghent\"[All Fields]) AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42812284", "42806604", "42806522", "42803990", "42795778", "42791518", "42787862", "42785629", "42783440", "42778470", "42777736", "42776745", "42776590", "42776096", "42774009", "42769951", "42768217", "42765598", "42764106", "42759120", "42758422", "42749538", "42748279", "42745049", "42743576", "42743531", "42743421", "42734858", "42732952", "42731022", "42728840", "42728390", "42726448", "42722421", "42722267", "42720637", "42719623", "42716272", "42712221", "42709914", "42708370", "42704426", "42702716", "42701205", "42697446", "42697217", "42696139", "42693699", "42693649", "42691142", "42685973", "42682152", "42679771", "42675370", "42671366", "42670210", "42637977", "42625973", "42565952", "42562719", "42562107", "42556988", "42545482", "42538169", "42533130", "42489613", "42425796", "42406526", "42360276", "42314080", "42307253", "42302881", "42283085", "42266002", "42251977", "42183183", "42177151", "42169394", "42161114", "42135181", "42128131", "42097337", "42092507", "42086167", "41949160", "41932435", "41916683", "41879753", "41819247", "41810961" ] }, "patient_experience": { "parameters": { "db": "pubmed", "term": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR aortopathy[Title/Abstract] OR aortopathies[Title/Abstract]) AND (patient reported OR quality of life OR qualitative OR psychosocial OR awareness OR shared decision OR rehabilitation)", "mindate": "2026/08/31", "maxdate": "2026/09/30", "datetype": "pdat", "retmode": "json", "retmax": 1000 }, "count": 86, "translated_query": "(\"aortic aneurysm, thoracic\"[MeSH Terms] OR \"thoracic aortic\"[Title/Abstract] OR \"ascending aortic\"[Title/Abstract] OR \"aortic dissection\"[Title/Abstract] OR \"aortopathy\"[Title/Abstract] OR \"aortopathies\"[Title/Abstract]) AND (((\"patient s\"[All Fields] OR \"patients\"[MeSH Terms] OR \"patients\"[All Fields] OR \"patient\"[All Fields] OR \"patients s\"[All Fields]) AND (\"reportable\"[All Fields] OR \"reporting\"[All Fields] OR \"reportings\"[All Fields] OR \"research report\"[MeSH Terms] OR (\"research\"[All Fields] AND \"report\"[All Fields]) OR \"research report\"[All Fields] OR \"report\"[All Fields] OR \"reported\"[All Fields] OR \"reports\"[All Fields])) OR (\"quality of life\"[MeSH Terms] OR (\"quality\"[All Fields] AND \"life\"[All Fields]) OR \"quality of life\"[All Fields]) OR (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields]) OR (\"psychosocial\"[All Fields] OR \"psychosocially\"[All Fields]) OR (\"awareness\"[MeSH Terms] OR \"awareness\"[All Fields] OR \"aware\"[All Fields] OR \"awarenesses\"[All Fields]) OR ((\"share\"[All Fields] OR \"shared\"[All Fields] OR \"shares\"[All Fields] OR \"sharing\"[All Fields] OR \"sharings\"[All Fields]) AND (\"decision\"[All Fields] OR \"decision s\"[All Fields] OR \"decisions\"[All Fields] OR \"decisive\"[All Fields] OR \"decisively\"[All Fields])) OR (\"rehabilitant\"[All Fields] OR \"rehabilitants\"[All Fields] OR \"rehabilitate\"[All Fields] OR \"rehabilitated\"[All Fields] OR \"rehabilitates\"[All Fields] OR \"rehabilitating\"[All Fields] OR \"rehabilitation\"[MeSH Terms] OR \"rehabilitation\"[All Fields] OR \"rehabilitations\"[All Fields] OR \"rehabilitative\"[All Fields] OR \"rehabilitation\"[MeSH Subheading] OR \"rehabilitation s\"[All Fields] OR \"rehabilitational\"[All Fields] OR \"rehabilitator\"[All Fields] OR \"rehabilitators\"[All Fields])) AND 2026/08/31:2026/09/30[Date - Publication]", "pmids": [ "42812842", "42811763", "42799237", "42794678", "42790905", "42785369", "42768306", "42767855", "42762216", "42760744", "42757899", "42755320", "42754184", "42754009", "42752801", "42752716", "42751386", "42751106", "42747000", "42745983", "42744127", "42735974", "42735960", "42735959", "42735958", "42735956", 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Nonlinear and Episodic Growth in the Natural History of Ascending Aortic Dilation. Can J Cardiol. 2026;42(9):2122-2132. PMID: 41935738. doi:10.1016/j.cjca.2026.03.035", "article_dates": [ "20260402" ], "pubdate": "2026Sep", "pmc": null, "pmid": "41935738", "title": "Nonlinear and Episodic Growth in the Natural History of Ascending Aortic Dilation.", "abstract": "Predicting ascending aortic growth is challenging. Linear, continuous assumptions may oversimplify biology. We evaluated the following: (i) whether baseline body size-indexed diameter has a nonlinear association with subsequent growth; and (ii) whether patient-level trajectories are continuous or episodic.\nFor this single-centr, retrospective study (2012-2024), the primary cohort (n = 3315; ≥ 2 computed tomography/magnetic resonance scans) modelled the association between baseline indexed size (z score) and annualized growth using multivariable linear regression and generalized additive models, adjusting for clinical covariates. A sub-cohort (n = 1055; ≥ 4 scans) was classified into the following longitudinal phenotypes: stable (total growth < 2.0 mm); stable-with-noise (total growth < 2.0 mm with alternating small changes); continuous growth (total growth ≥ 2.0 mm without an episodic event); and discontinuous/episodic growth (total growth ≥ 2.0 mm with ≥ 1 growth episode, defined as a diameter increase ≥ 2.0 mm within 1 interval or across 2 adjacent intervals).\nIn the primary cohort, baseline z score showed a significant nonlinear (U-shaped) association with subsequent growth in generalized additive models (P < 0.001), with higher growth for small (z < 0) and severely dilated (z > 5) aortas. The size-growth relationship was significantly moderated by age, sex, and blood pressure. In the sub-cohort, the phenotype distribution was as follows: stable, 50.4% (532 of 1055); stable-with-noise, 21.6% (228 of 1055); continuous, 5.4% (57 of 1055); and discontinuous/episodic, 22.6% (238 of 1055). Among patients with total growth ≥ 2.0 mm (n = 295), 81% (238 of 295) were episodic, and 58.3% (172 of 295) had a nondilated baseline aorta (z < 2).\nThe cohort-level size-growth relationship is nonlinear, and episodic growth behavior dominates among those that grow larger. These findings support reassessing surveillance intervals, risk communication, and threshold-based decision pathways in thoracic aortic disease.", "journal": "Can J Cardiol", "date": "2026Sep", "authors": [ "Campello JorgeCarlos AlbertoCADepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA; Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.", "MarwayPrabhvir SPSDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA; Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.", "SpahlingerGregoryGDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA; Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA." ], "types": [ "Journal Article" ], "selection": "in publication-date window" }, { "citation": "Coselli JS, et al. Ten-year outcomes of valve-replacing versus valve-sparing aortic root replacement in patients with Marfan syndrome: An observational multicenter study. J Thorac Cardiovasc Surg. 2026;172(3):537-544.e13. PMID: 42128131. doi:10.1016/j.jtcvs.2026.04.044", "article_dates": [ "20260512" ], "pubdate": "2026Sep", "pmc": null, "pmid": "42128131", "title": "Ten-year outcomes of valve-replacing versus valve-sparing aortic root replacement in patients with Marfan syndrome: An observational multicenter study.", "abstract": "We compared 10-year outcomes of aortic valve-replacing (AVR) and aortic valve-sparing (AVS) root replacement in patients with Marfan syndrome (MFS).\nPatients who met strict Ghent diagnostic criteria for MFS and who underwent either AVR or AVS between March 1, 2005, and December 31, 2010, were enrolled in a 3-year prospective observational study. The follow-up, which was clinical and echocardiographic, was later extended to 20 years. Time-to-event analyses were performed with and without inverse probability weighting to adjust for baseline differences; comparison between groups assessed major adverse valve-related (MAVRE) and other events.\nOf 316 patients enrolled, 77 underwent AVR and 239 underwent AVS; 214 gave reconsent for 20-year follow-up. For survivors, median durations for clinical and echocardiographic follow-up were 12.1 years (interquartile range, 4.6-15.1 y) and 10.1 years (interquartile range, 3.0-14.1 y), respectively. Ten-year adjusted survival rates for the AVR and AVS groups were similar (77.9% ± 4.4% vs 88.4% ± 2.6%; P = .2), as were adjusted rates of MAVRE (36.1% ± 4.2% vs 35.0% ± 3.3%; P = .5). Inverse probability weighting-adjusted competing-risk modeling associated AVS with greater cumulative incidences of structural valve deterioration or nonstructural valve dysfunction (24.9% vs 4.4%; P = .01) and aortic regurgitation ≥2+ (26.5% vs none; P < .001); similar analysis associated AVR with a greater cumulative incidence of bleeding (23.2% vs 2.7%; P < .001).\nTen years postoperatively, the accumulation of structural valve deterioration in patients who underwent AVS and bleeding events in patients who underwent AVR balance out in terms of MAVRE. We plan to follow this cohort for 20 years after aortic root replacement, which may reveal late differences in reintervention rates.", "journal": "J Thorac Cardiovasc Surg", "date": "2026Sep", "authors": [ "CoselliJoseph SJSMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex; The Texas Heart Institute at Baylor College of Medicine, Houston, Tex; Department of Cardiovascular Surgery, CHI St Luke's Health-Baylor St Luke's Medical Center, Houston, Tex. Electronic address: jcoselli@bcm.edu.", "MillerD CraigDCDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.", "VolguinaIrinaIMichael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex." ], "types": [ "Journal Article", "Observational Study", "Multicenter Study", "Comparative Study" ], "selection": "in publication-date window" }, { "citation": "Yamazaki C, et al. Cardiac Rehabilitation Improves Outcomes After Thoracic Aortic Aneurysm Repair. JACC Asia. 2026;6(9):2066-2077. PMID: 42283670. doi:10.1016/j.jacasi.2026.04.018", "article_dates": [ "20260612" ], "pubdate": "2026Sep", "pmc": "PMC13554771", "pmid": "42283670", "title": "Cardiac Rehabilitation Improves Outcomes After Thoracic Aortic Aneurysm Repair.", "abstract": "Cardiac rehabilitation (CR) improves prognosis in patients with ischemic heart disease and heart failure. However, its effectiveness in aortic diseases, such as thoracic aortic aneurysms (TAA), remains unclear.\nThis study aimed to evaluate the effects of outpatient CR on major adverse cardiovascular events (MACEs) and all-cause mortality after open repair surgery for TAA.\nThis retrospective cohort study analyzed 1,710 patients who underwent open TAA repair between 2003 and 2015. Patients were divided into a CR group (n = 419) and a non-CR group (n = 1,193). Follow-up duration was 1,603 (734-2,301) days in the CR group and 1,169 (610-1,991) days in the non-CR group. Propensity score matching was used to balance the baseline characteristics. Primary outcomes were MACE and all-cause mortality.\nAfter matching, the CR group exhibited a significantly lower incidence of MACEs (HR: 0.58; 95% CI: 0.34-0.97; P = 0.039) and all-cause mortality (HR: 0.59; 95% CI: 0.37-0.94; P = 0.026). The 5-year estimated all-cause mortality rate was 7.5% (95% CI: 4.9%-11.3%) and 12.3% (95% CI: 8.7%-17.3%), respectively. Cardiovascular deaths were 1.7% (7 of 419) and 2.9% (35 of 1,193) in the CR and non-CR groups, respectively (P = 0.17). Former smoking was independently associated with higher all-cause mortality (HR: 2.69; 95% CI: 1.62-4.45; P = 0.001). In former smokers, CR was associated with lower all-cause mortality (log-rank P = 0.008).\nOutpatient CR following TAA surgery was associated with reduced risks of MACE and all-cause mortality, even in the patients with former smoking.", "journal": "JACC Asia", "date": "2026Sep", "authors": [ "YamazakiChiemiCDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, Japan; Department of Cardiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.", "NakayamaAtsukoADepartment of Cardiology, Sakakibara Heart Institute, Tokyo, Japan. Electronic address: atsukonakanaka@gmail.com.", "SakamotoJunkoJDepartment of Rehabilitation, Sakakibara Heart Institute, Tokyo, Japan." ], "types": [ "Journal Article" ], "selection": "in publication-date window" }, { "citation": "Gupta Y, et al. CIRSE Standards of Practice on the Endovascular Management of Descending Thoracic Aortic Disease. Cardiovasc Intervent Radiol. 2026;49(9):1645-1656. PMID: 42545482. doi:10.1007/s00270-026-04477-5", "article_dates": [ "20260803" ], "pubdate": "2026Sep", "pmc": "PMC13597586", "pmid": "42545482", "title": "CIRSE Standards of Practice on the Endovascular Management of Descending Thoracic Aortic Disease.", "abstract": "Endovascular management of descending thoracic aortic disease (aneurysm, acute aortic syndrome and traumatic injury) is an effective, minimally invasive treatment that over the last 20 years has superseded surgical repair and become the standard of care. This CIRSE Standards of Practice document recommends best evidence-based practices for the endovascular management of descending thoracic aortic disease. This includes diagnostic imaging, surveillance, indications for intervention, endovascular treatments, their outcomes, and follow-up. The writing group, established by the CIRSE Standards of Practice Committee, reviewed the literature, and the final recommendations were formulated through consensus. Endovascular treatment has an established role in the successful management of thoracic aortic disease, and this Standards of Practice document provides up-to-date recommendations for its safe performance.", "journal": "Cardiovasc Intervent Radiol", "date": "2026Sep", "authors": [ "GuptaYuriYUniversity Hospitals Sussex, Brighton, UK. yuri.gupta1@nhs.net.", "VaughanSamuelSUniversity Hospitals Sussex, Brighton, UK.", "FanelliFabrizioFVascular and Interventional Radiology Department, Careggi' University Hospital, Florence, Italy." ], "types": [ "Journal Article", "Review" ], "selection": "in publication-date window" }, { "citation": "Płońska-Gościniak E, et al. Sex-specific Patterns of Valvulo-Aortopathy in Bicuspid Aortic Valve According to the International Consensus Framework: Insights from the RE-BAV Registry. Eur Heart J Cardiovasc Imaging. 2026. PMID: 42670210. doi:10.1093/ehjci/jeag233", "article_dates": [ "20260831" ], "pubdate": "2026Aug31", "pmc": null, "pmid": "42670210", "title": "Sex-specific Patterns of Valvulo-Aortopathy in Bicuspid Aortic Valve According to the International Consensus Framework: Insights from the RE-BAV Registry.", "abstract": "To characterise sex-specific patterns of bicuspid aortic valve (BAV) valvulo-aortopathy using consensus phenotyping and to assess how aortic normalisation strategies influence sex-related differences in aortic dimensions.\nWe analysed 808 adults with BAV (mean age 49.9 ± 17.5 years; 588 men) from the RE-BAV registry. Valve morphology, aortopathy phenotypes, and clinical valvulo-aortopathy categories were classified according to consensus definitions. Typical and uncomplicated forms were additionally analysed together as a non-complex category. Proximal aortic dimensions were defined as the aortic root and ascending aorta.Valve morphology distribution did not differ by sex. Although the prevalence of aortic dilatation was similar, phenotype distribution differed: women more frequently exhibited the extended phenotype (34.7% vs 23.3%, p = 0.001), whereas the root phenotype was more common in men (15.1% vs 7.8%, p = 0.006). Moderate-to-severe aortic regurgitation was more prevalent in men (50.3% vs 29.1%, p < 0.001). Sex differences in proximal aortic dimensions varied by normalisation strategy. For the ascending aorta, indexing to body surface area yielded larger values in women (21.1 ± 4.0 vs 20.0 ± 4.0 mm/m2, p = 0.001), whereas diameter/height showed no sex-related difference at this level. Conversely, the cross-sectional area-to-height ratio remained higher in men across proximal segments, most prominently at the sinuses of Valsalva (6.9 ± 2.0 vs 5.6 ± 1.6 cm2/m, p < 0.001). Age was independently associated with larger proximal aortic dimensions across all strategies.\nSex-related differences in BAV involved aortopathy phenotype, aortic regurgitation burden, and proximal aortic dimensions. Interpretation of proximal aortic dimensions depended on the normalisation strategy used, indicating that indexing methods should not be treated as interchangeable.", "journal": "Eur Heart J Cardiovasc Imaging", "date": "2026Aug31", "authors": [ "Płońska-GościniakEdytaE0000-0003-1632-3261Department of Cardiology, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland.", "KosmalaWojciechW0000-0003-3807-8201Institute of Heart Diseases, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.", "PacholewiczJerzyJ0000-0001-8484-0899Department of Cardiac Surgery, Pomeranian Medical University, Powstańców Wlkp. 72, 70-111 Szczecin, Poland." ], "types": [ "Journal Article" ], "selection": "in publication-date window" }, { "citation": "DePaolo J, et al. Thoracic aortic disease: prognostic role of gene variants and polygenic risk scores. Eur Heart J. 2026. PMID: 42678067. doi:10.1093/eurheartj/ehag518", "article_dates": [ "20260901" ], "pubdate": "2026Sep01", "pmc": null, "pmid": "42678067", "title": "Thoracic aortic disease: prognostic role of gene variants and polygenic risk scores.", "abstract": "Thoracic aortic aneurysm and dissection (TAAD) can have catastrophic health consequences. Eleven genes have strong or definitive evidence for causing heritable TAAD (HTAAD). The aim of this work was to determine the prevalence and effect of rare, pathogenic or likely pathogenic (P/LP) variants in HTAAD genes on the association of TAAD diagnoses, and whether increased polygenic risk is associated with an additive effect on monogenic risk.\nThis genetic association study used data from Penn Medicine Biobank (PMBB) and MyCode Biobank. P/LP HTAAD gene variants were adjudicated according to American College of Medical Genetics and Genomics standards. A polygenic risk score (PRS) was derived from a genome-wide association study of aortic diameter to assess polygenic TAAD risk. The main outcome of interest, TAAD, was identified using an algorithmic review of electronic health records. Regression analyses were performed to determine the monogenic and polygenic effects on TAAD risk.\nAcross the two cohorts, .2%-.3% of participants carried a P/LP HTAAD gene variant. Individuals carrying P/LP HTAAD gene variants had a significantly higher odds of TAAD compared to non-carriers [odds ratio (OR) 13.5, 95% confidence interval (CI) 5.3-34.6, P < .001] with variable effects when stratified by gene. A one standard deviation increase in the PRS was associated with an OR for TAAD of 1.43 (95% CI 1.39-1.47, P < .001). TAAD prevalence was higher among individuals carrying a P/LP HTAAD gene variant in the highest PRS quintile compared to carriers in the lowest PRS quintile (relative risk 2.32, 95% CI 1.29-4.17, P < .01), suggesting that polygenic risk may be an important additive factor in rare variant TAAD risk.\nP/LP HTAAD gene variants confer a substantial population-level increased risk of TAAD. Polygenic risk represents an additive factor for rare variant TAAD risk, suggesting that integrating monogenic and polygenic risks has the potential to enhance patient risk stratification and treatment.", "journal": "Eur Heart J", "date": "2026Sep01", "authors": [ "DePaoloJohnJ0000-0002-6829-2594Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.", "SmelserDiane TDTDepartment of Genomic Health, Weis Center for Research, Geisinger Health System, Danville, PA, USA.", "GuoDongchuanDDivision of Medical Genetics, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA." ], "types": [ "Journal Article" ], "selection": "in publication-date window" }, { "citation": "Dineen EH, et al. Clinical Considerations for the Care of the Tactical Athlete With Cardiovascular Abnormalities: A Scientific Statement From the American College of Cardiology and the American Heart Association. Circulation. 2026. PMID: 42691142. doi:10.1161/CIR.0000000000001476", "article_dates": [ "20260903" ], "pubdate": "2026Sep03", "pmc": null, "pmid": "42691142", "title": "Clinical Considerations for the Care of the Tactical Athlete With Cardiovascular Abnormalities: A Scientific Statement From the American College of Cardiology and the American Heart Association.", "abstract": "The American College of Cardiology/American Heart Association Scientific Statement, \"Clinical Considerations for the Care of the Tactical Athlete With Cardiovascular Abnormalities,\" was written to provide guidance and education for clinicians caring for the tactical athlete (ie, firefighters, law enforcement officers, military) with cardiovascular disease or risk for cardiovascular disease, and for the organizations overseeing the care and wellness of these athletes. The considerations are shaped by the interaction between occupational demands and fit for full duty assessments, including risk discussions about how a cardiovascular event in a tactical athlete could impact teammates' well-being, community safety, and overall mission success.\nThis scientific statement is organized into 11 sections focused on cardiovascular disease processes and other topics that are relevant when considering the potential risks and benefits of performing tasks specific to the tactical athlete. Task forces, comprised of experts in tactical athlete domains, sports cardiology, and the respective topics covered, were assigned to each section, and specific \"Clinical Considerations Tables\" for clinicians to reference were prepared. Comprehensive literature reviews and an emphasis on tactical athlete-focused data, as available, were integral in the writing of all clinical considerations presented. The framework mirrors that of the recently published, \"Clinical Considerations for Competitive Sports Participation for Athletes With Cardiovascular Abnormalities: A Scientific Statement From the American Heart Association and American College of Cardiology.\"\nThe specific sections in this document include: Section 1: Tactical Tasks Classification; Section 2: The Tactical Athlete Preparticipation Cardiac Evaluation; Section 3: Ethical and Legal Aspects of Tactical Clinical Management; Section 4: Genetic Cardiomyopathies; Section 5: Myocarditis and Other Acquired Cardiac Conditions; Section 6: Congenital Heart Disease; Section 7: Aortopathy, Bicuspid Aortic Valve, and Spontaneous Coronary Artery Dissection; Section 8: Syncope, SCA, Arrhythmias, and Devices; Section 9: Cardiac Channelopathies; Section 10: Older Tactical Athlete; Section 11: Environmental Exposures, PED/S, and Additional Cardiac Conditions and Considerations. Each section provides a summary detailing the rationale for key clinical considerations and the respective Clinical Considerations Table(s).", "journal": "Circulation", "date": "2026Sep03", "authors": [ "DineenElizabeth HEH", "HaigneyMark CMC", "LevineBenjamin DBD" ], "types": [ "Journal Article", "Review" ], "selection": "in publication-date window" }, { "citation": "Kim JH, et al. Clinical Considerations for Competitive Sports Participation for Athletes With Cardiovascular Abnormalities: A Scientific Statement From the American Heart Association and American College of Cardiology. J Am Coll Cardiol. 2025;85(10):1059-1108. PMID: 39976316. doi:10.1016/j.jacc.2024.12.025", "article_dates": [ "20250220" ], "pubdate": "2025Mar18", "pmc": "PMC12145891", "pmid": "39976316", "selection": "2025 guideline catch-up outside window" }, { "citation": "Mohammed KA, et al. Targeting the ERK Signaling Pathway to Halt Adventitia Remodeling of Ascending Thoracic Aortic Aneurysm. JACC Basic Transl Sci. 2026;11(10):101665. PMID: 42790271. doi:10.1016/j.jacbts.2026.101665", "article_dates": [ "20260925" ], "pubdate": "2026Sep25", "pmc": null, "pmid": "42790271", "title": "Targeting the ERK Signaling Pathway to Halt Adventitia Remodeling of Ascending Thoracic Aortic Aneurysm.", "abstract": "Ascending thoracic aortic aneurysms (AsTAAs) are life-threatening and lack effective drug treatments. This study investigated whether abnormal mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) activation in adventitial pericytes contributes to aneurysm progression. Human AsTAA tissue showed vasa vasorum remodeling and displaced pericytes. Isolated AsTAA-pericytes showed increased MEK/ERK signaling, proliferation, migration, proteolytic activity, proinflammatory secretome, and altered angiogenic function. These changes were reversed by the MEK inhibitor PD0325901. In a mouse model, short-term MEKi treatment reduced aortic dilatation, improved compliance, preserved elastin, and lessened inflammation, without adverse effects. This is the first study identifying dysregulated adventitial pericytes as a hallmark of AsTAA, supporting MEKi as a promising therapeutic.", "journal": "JACC Basic Transl Sci", "date": "2026Sep25", "authors": [ "MohammedKhaled AkKABristol Heart Institute, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom; Department of Cardiothoracic Surgery, Faculty of Medicine, Assiut University, Assiut, Egypt; Bristol Heart Institute, Bristol Royal Infirmary, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom.", "AvolioElisaEBristol Heart Institute, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. Electronic address: elisa.avolio@bristol.ac.uk.", "AlvinoValeria VVVBristol Heart Institute, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom." ], "types": [ "Journal Article" ], "selection": "in publication-date window" }, { "citation": "Grewal N, et al. Co-creating a patient-driven digital monitoring agenda for thoracic aortic disease: a multiphase qualitative study. BMJ Open. 2026;16(9):e121086. PMID: 42790905. doi:10.1136/bmjopen-2026-121086", "article_dates": [ "20260925" ], "pubdate": "2026Sep25", "pmc": null, "pmid": "42790905", "title": "Co-creating a patient-driven digital monitoring agenda for thoracic aortic disease: a multiphase qualitative study.", "abstract": "To identify, through structured co-creation with patients across the thoracic aortic disease (TAD) spectrum, which domains of between-visit monitoring patients themselves consider meaningful and to translate these into a patient-driven digital monitoring agenda.\nQualitative co-creation study in four sequential phases: secondary analysis of existing patient engagement material (A), targeted focus groups addressing under-represented perspectives (B), a mixed-stakeholder co-design workshop (C) and a member-check validation session (D). Analysis used reflexive thematic analysis and framework synthesis. Reported following Consolidated Criteria for Reporting Qualitative Research (COREQ).\nA single Dutch tertiary referral centre for TAD, 2024-2025.\nAdults (≥18 years) with TAD, purposively sampled across three trajectories: surgically managed acute dissection, elective aortic surgery and aneurysm or bicuspid aortic valve under surveillance. Phase A, 45 participants in six sessions; phase B, 13 in two focus groups; phase C, 9 (6 patients, 3 healthcare professionals); phase D, 9 participants from earlier phases.\nPatient-derived domains considered relevant to digital monitoring and their translation into components of a monitoring agenda, together with the conditions participants regarded as necessary for such monitoring to be acceptable.\nFive domains recurred across trajectories: managing uncertainty and fear of recurrence, interpreting symptoms and bodily signals, blood pressure self-monitoring and variability, life participation including activity and reproductive decisions and accessibility and proportionality. These were translated into an agenda comprising symptom contextualisation, longitudinal blood pressure trends, patient-reported outcomes, contextual activity feedback, educational decision support and transparent escalation pathways. Participants framed monitoring as an adjunct to imaging surveillance, not a replacement, emphasising interpretability and restrained alerting.\nStructured patient engagement and iterative co-design produced a patient-driven digital monitoring agenda for TAD integrating biomedical and psychosocial dimensions, describing priorities articulated by these participants rather than their distribution and providing a foundation for developing and evaluating hybrid digital surveillance models in aortic care.", "journal": "BMJ Open", "date": "2026Sep25", "authors": [ "GrewalNimratN0000-0001-9981-8336Department of Cardiothoracic Surgery, Amsterdam UMC Locatie AMC, Amsterdam, Netherlands n.grewal@amsterdamumc.nl.", "BacourNoraN0009-0000-6926-9890Department of Cardiothoracic Surgery, Amsterdam UMC Locatie AMC, Amsterdam, Netherlands.", "AouraghYounessYDepartment of Cardiothoracic Surgery, Amsterdam UMC Locatie AMC, Amsterdam, Netherlands." ], "types": [ "Journal Article" ], "selection": "in publication-date window" }, { "citation": "Gontarz B, et al. Outcomes of TEVAR for uncomplicated subacute type B aortic dissection in the IRAD registry. J Vasc Surg. 2026. PMID: 42805273. doi:10.1016/j.jvs.2026.09.022", "article_dates": [ "20260928" ], "pubdate": "2026Sep28", "pmc": null, "pmid": "42805273", "title": "Outcomes of TEVAR for uncomplicated subacute type B aortic dissection in the IRAD registry.", "abstract": "Thoracic endovascular aortic repair (TEVAR) in uncomplicated type B acute aortic dissection (TBAAD) remains controversial. Compared to best medical therapy (BMT), TEVAR has demonstrated benefits in aortic remodeling; however, this intervention does include procedural related risks.\nThe International Registry of Acute Aortic Dissection (IRAD) database was queried from January 1996 to September 2023 for all uncomplicated TBAAD. Patients receiving subacute (15-90 days) TEVAR (sTEVAR) and BMT were included. Baseline comorbidities were recorded. The primary outcome was survival at 4 years. Secondary outcomes included delayed aortic interventions, progression of aortic disease, new dissection, re-hospitalization, rupture, and stroke.\nDuring the study period, 1373 uncomplicated TBAAD patients were entered into the registry and had follow-up data available. Sixty-three patients (4.6%) underwent sTEVAR and 1310 (95.4%) received BMT. Four-year survival was similar between the groups (sTEVAR 87% vs BMT 84%, p=0.925). At three years, the sTEVAR group had higher rates of new dissection (13.9% vs 4.8%, p=0.002), all within 1 year of TEVAR. Progression of dissection, aneurysmal degeneration, reintervention, rupture, stroke, and re-hospitalization were comparable between groups.\nAs compared to BMT, sTEVAR had similar rates of survival. New dissection was higher in the sTEVAR group. TEVAR may have a role in subacute uncomplicated TBAAD, and ongoing randomized trials are essential to understand which patients benefit from intervention.", "journal": "J Vasc Surg", "date": "2026Sep28", "authors": [ "GontarzBrendanBDivision of Vascular Surgery, Hartford Hospital, UCONN School of Medicine, Hartford, CT, USA.", "LeshnowerBradleyBDivision of Cardiothoracic Surgery, Emory University, Atlanta, GA, USA.", "ArnaoutakisGeorgeGDivision of Cardiothoracic Surgery, Dell Medical School at the University of Texas at Austin, Austin, TX, USA." ], "types": [ "Journal Article" ], "selection": "in publication-date window" }, { "citation": "Jung M, et al. Global, Regional, and National Burden of Aortic Aneurysm, 1990-2021, and Projections to 2050. J Korean Med Sci. 2026;41(35):e237. PMID: 42708483. doi:10.3346/jkms.2026.41.e237", "article_dates": [ "20260907" ], "pubdate": "2026Sep07", "pmc": "PMC13550982", "pmid": "42708483", "title": "Global, Regional, and National Burden of Aortic Aneurysm, 1990-2021, and Projections to 2050.", "abstract": "Despite being a life-threatening condition that may rupture without prior symptoms-potentially resulting in sudden death-comprehensive research on its global burden remains limited. This study was conducted to estimate the global burden and associated risk factors of aortic aneurysms and to project future trends through to 2050.\nData on aortic aneurysms were extracted from the Global Burden of Disease Study 2021, encompassing 204 countries and territories from 1990 to 2021. An aortic aneurysm was defined as a full-thickness dilation of the aorta, including both abdominal and thoracic types. The study stratified the burden by geographical region, age, year, sex, and Socio-demographic Index (SDI). Additionally, attributable risk factors were analyzed, and projections for the burden of aortic aneurysms in 2050 were generated using scenario modelling. These models evaluated the potential impact of eliminating smoking, dietary risks, and high body mass index among adults through improved behavioral and metabolic risk management.\nIn 2021, there were an estimated 153.93 thousand (95% uncertainty interval [UI], 138.41-165.74) deaths globally due to aortic aneurysm. From 1990 to 2021, the global age-standardized mortality rate (ASMR) decreased from 2.54 (95% UI, 2.35-2.69) to 1.86 (1.67-2.00), and the age-standardized years of life lost rates declined from 48.79 (46.01-51.80) to 36.54 (33.52-39.46) per 100,000 population. While regions with higher SDI exhibited a sharp decline, the burden remained significant in both high (ASMR, 2.87 [95% UI, 2.51-3.06]) and high-middle (1.79 [1.66-1.92]) SDI areas. Conversely, regions with lower SDI demonstrated an increasing trend. Males consistently exhibited a higher burden than females, and burden increased with age. Tobacco use and high systolic blood pressure were identified as the predominant risk factors for aortic aneurysm-related mortality. Specifically, tobacco use was a more significant risk factor in males, while high systolic blood pressure was more prominent in females. Projections suggest that the global ASMR for aortic aneurysm will remain stable under the reference scenario in 2022 (1.87 [95% UI, 1.67-2.02]) and 2050 (1.44 [1.23-1.70]). However, improved behavioral and metabolic risk management could substantially reduce rates to 0.84 (0.71-0.99) by 2050.\nThe findings demonstrate a global decline in the burden of aortic aneurysms, though pronounced regional differences persist. Effective management strategies must be tailored to account for healthcare infrastructure, socioeconomic status, and risk factors unique to each geographical region.", "journal": "J Korean Med Sci", "date": "2026Sep07", "authors": [ "JungMinwooM0009-0003-2037-4763Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, Korea.", "JeongJinyoungJ0009-0001-8849-7941Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Korea.", "JoYeonaY0009-0006-7180-6011Department of Precision Medicine (Medical AI), Kyung Hee University College of Medicine, Seoul, Korea." ], "types": [ "Journal Article" ], "selection": "in publication-date window" }, { "citation": "Jacobson TA, et al. Real-world adherence to guideline-directed imaging surveillance in chronic aortic dissection and thoracic aortic aneurysm: a scoping review. Ann Thorac Surg. 2026. PMID: 42722267. doi:10.1016/j.athoracsur.2026.08.021", "article_dates": [ "20260910" ], "pubdate": "2026Sep10", "pmc": null, "pmid": "42722267", "title": "Real-world adherence to guideline-directed imaging surveillance in chronic aortic dissection and thoracic aortic aneurysm: a scoping review.", "abstract": "Guideline-directed imaging surveillance (GDIS) is recommended after aortic dissection (AD) and for thoracic aortic aneurysm (TAA); however, real-world adherence and outcomes are uncertain.\nFollowing PRISMA-ScR guidance, we searched six databases from inception through May 2026 for studies from the United States or Canada reporting imaging surveillance or clinical follow-up after AD or for TAA. Two reviewers independently screened records and extracted data on surveillance rates, cohort characteristics, radiographic findings, interventions, and survival. Findings were synthesized narratively.\nAcross 13 retrospective studies, enrollments included 1,344 patients with Type A AD, 865 with Type B AD (357 treated invasively at index hospitalization and 508 initially treated medically), 533 with repaired TAA, and 29,185 with unrepaired TAA. Definitions and surveillance intervals varied, and most studies were single-center chart reviews. Adherence to GDIS was generally low and variable. Surveillance was associated with detection of adverse radiographic findings and higher intervention rates. Among studies evaluating survival, two associated imaging surveillance with lower mortality, three reported nonsignificant trends toward lower mortality, and two associated greater surveillance with higher mortality. Few studies used regional or national data capable of capturing surveillance outside the primary health system.\nReal-world adherence to GDIS for AD and TAA is low and heterogeneous. Surveillance identifies clinically important radiographic findings and is associated with more interventions, but associations with improved survival remains limited. Multicenter studies using regional or national data systems are needed to define effective, risk-based surveillance intervals and inform implementation strategies.", "journal": "Ann Thorac Surg", "date": "2026Sep10", "authors": [ "JacobsonTyler ATADepartment of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.", "EngelJoshua SJSFeinberg School of Medicine, Northwestern University, Chicago, IL, USA.", "KandulaViswajitVColumbia University Vagelos College of Physicians and Surgeons, New York, NY, USA." ], "types": [ "Journal Article", "Review" ], "selection": "in publication-date window" }, { "citation": "Abbasciano RG, et al. Interactions Between Health Inequalities on the Management and Outcomes of Thoracic Aortic Disease in England: A National Cohort Study. J Am Heart Assoc. 2026:e047851. PMID: 42757899. doi:10.1161/JAHA.125.047851", "article_dates": [ "20260918" ], "pubdate": "2026Sep18", "pmc": null, "pmid": "42757899", "title": "Interactions Between Health Inequalities on the Management and Outcomes of Thoracic Aortic Disease in England: A National Cohort Study.", "abstract": "The aim of this study was to evaluate the intersectionality between measured causes of health inequality and clinical factors that influence treatment decisions and regional variations in care and survival for people with thoracic aortic disease (TAD) in England.\nThe target population was all new TAD diagnoses in English hospitals between April 2013 and March 2018 with at least a 1-year follow-up. Adjusted regression models analyzed the associations between age, sex, race and ethnicity, socioeconomic deprivation, and geographic region with 1-year all-cause death, early elective thoracic aortic intervention, and referral for imaging surveillance or clinical genetics screening.\nThe analysis cohort included 33 793 new TAD diagnoses with complete baseline and follow-up data. In multivariate analyses, older patients, women, and people from economically deprived areas, were more likely to die within 1 year of diagnosis. Exploratory analyses showed that older people, people of Asian or Black race, and those from deprived areas were less likely to undergo early treatment, and older people, women, and people from deprived areas were more likely to undergo surveillance scans within 6 months of diagnosis. People from areas of deprivation were less likely to be referred for genetic screening. After adjustment for baseline differences and health inequalities, there was significant regional variation in the proportion of people with newly diagnosed TAD who underwent treatment and aortic surveillance.\nThere are multilevel sources of inequality in access to care and survival following a diagnosis with TAD in England. These findings expose a significant evidence-to-practice gap and the need for national strategies to implement equitable standardized care pathways.", "journal": "J Am Heart Assoc", "date": "2026Sep18", "authors": [ "AbbascianoRiccardo GiuseppeRG0000-0001-6004-8741Department of Cardiovascular Sciences University of Leicester Leicester UK.", "MikszaJoanneJ0000-0001-7063-0145Department of Cardiovascular Sciences University of Leicester Leicester UK.", "DionneJoanna ColleenJC0000-0002-9401-6868Department of Health Research Methods, Evidence, and Impact McMaster University Hamilton Canada." ], "types": [ "Journal Article" ], "selection": "in publication-date window" }, { "citation": "Nilsson F, et al. Health-related quality of life, psychological well-being and physical activity in patients with mild-to-moderate ascending aortic dilation - a cross-sectional case-control study. BMC Cardiovasc Disord. 2026;26(1). PMID: 42768306. doi:10.1186/s12872-026-06616-9", "article_dates": [ "20260921" ], "pubdate": "2026Sep21", "pmc": "PMC13591847", "pmid": "42768306", "title": "Health-related quality of life, psychological well-being and physical activity in patients with mild-to-moderate ascending aortic dilation - a cross-sectional case-control study.", "abstract": "To investigate health-related quality of life (HRQoL), psychological well-being and physical activity in patients with mild-to-moderate ascending aortic dilation.\nWhile ascending aortic dilation often require lifelong surveillance due to the increased risk of severe complications like aortic dissection or rupture, the impact of living with this known risk on patients' psychological well-being and overall quality of life remains less studied.\nSubjects with ascending aortic dilation ≥ 40 mm and age- and sex-matched controls were identified in the general population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) in Linköping (n = 5053). Of these, 67 cases and 50 controls completed the questionnaires. HRQoL, psychological well-being, physical activity and capacity were assessed using validated forms. Group comparisons were made with independent t-tests or Mann-Whitney U. For correlation analyses, Spearman's rank correlation was used.\nNo statistically significant differences in quality of life were observed between cases and controls. Anxiety and depression scores were likewise comparable across groups (p = 0.228 and 0.307, respectively). Perceived stress (p = 0.096), physical capacity (p = 0.173), and physical activity (p = 0.471) also did not differ significantly between cases and controls. With respect to sedentary behaviour, cases demonstrated a higher mean rank than controls (62 vs. 52), although the p-value marginally exceeded the conventional threshold for significance (p = 0.062). Finally, no significant correlations were identified between aortic diameter and perceived stress, anxiety, or depression.\nIn this population-based cohort, no statistically significant differences in HRQoL, psychological well-being, and physical activity were observed between subjects with mild to moderate ascending aortic dilation and matched controls. However, given the small sample size, small differences between groups cannot be excluded. Balanced management strategies that promote safe physical activity, psychological well-being and HRQoL remain important in this population.", "journal": "BMC Cardiovasc Disord", "date": "2026Sep21", "authors": [ "NilssonFredrikFDepartment of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden. fredrik.nilsson@liu.se.Clinical Department of Cardiology in Linköping, Region Östergötland, Linköping, SE-581 85, Sweden. fredrik.nilsson@liu.se.", "LindenbergerMarcusMDepartment of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.Clinical Department of Cardiology in Linköping, Region Östergötland, Linköping, SE-581 85, Sweden.", "BorgSabinaSDepartment of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.Clinical Department of Cardiology in Linköping, Region Östergötland, Linköping, SE-581 85, Sweden.Department of Health, Medicine and Caring Sciences, Division of Physiotherapy, Linköping University, Linköping, Sweden." ], "types": [ "Journal Article" ], "selection": "in publication-date window" } ], "triage": "14 date-window records retained; 334 screened records not added. One 2025 guideline catch-up added. No landmark deep note. Case reports, commentary, unrelated records, narrow technical series and exploratory biomarkers generally excluded.", "clinicaltrials_endpoint_template": "https://clinicaltrials.gov/api/v2/studies/{NCT_ID}", "tracked_trial_count": 52, "trials": [ { "id": "NCT00126204", "title": "Adjunctive Treatment With Doxycycline to Enhance the Durability of Endovascular Aortic Aneurysm Repair", "status": "COMPLETED", "last_update": { "date": "2010-03-04", "type": "ESTIMATED" }, "primary_completion": null, "completion": { "date": "2006-07" }, "results": false, "results_posted": null, "enrollment": { "count": 75 } }, { "id": "NCT00429364", "title": "Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome", "status": "COMPLETED", "last_update": { "date": "2025-03-07", "type": "ACTUAL" }, "primary_completion": { "date": "2014-02", "type": "ACTUAL" }, "completion": { "date": "2014-02", "type": "ACTUAL" }, "results": true, "results_posted": { "date": "2015-04-01", "type": "ESTIMATED" }, "enrollment": { "count": 608, "type": "ACTUAL" } }, { "id": "NCT00485368", "title": "Angiotensin Converting Enzyme Inhibitors in Marfan Syndrome", "status": "COMPLETED", "last_update": { "date": "2007-06-13", "type": "ESTIMATED" }, "primary_completion": null, "completion": { "date": "2006-09", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 17, "type": "ACTUAL" } }, { "id": "NCT00538967", "title": "The Effect of Doxycycline on Matrix Metalloproteinase Expression and Activity in the Abdominal Aneurysm", "status": "COMPLETED", "last_update": { "date": "2007-10-03", "type": "ESTIMATED" }, "primary_completion": null, "completion": { "date": "2005-08", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 60, "type": "ACTUAL" } }, { "id": "NCT00593710", "title": "Losartan Versus Atenolol for the Treatment of Marfan Syndrome", "status": "COMPLETED", "last_update": { "date": "2012-07-12", "type": "ESTIMATED" }, "primary_completion": { "date": "2010-10", "type": "ACTUAL" }, "completion": { "date": "2011-12", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 17, "type": "ACTUAL" } }, { "id": "NCT00683124", "title": "Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients", "status": "UNKNOWN", "last_update": { "date": "2011-07-22", "type": "ESTIMATED" }, "primary_completion": { "date": "2013-07", "type": "ESTIMATED" }, "completion": { "date": "2013-07", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 291, "type": "ESTIMATED" } }, { "id": "NCT00723801", "title": "Effects of Losartan Versus Atenolol on Aortic and Cardiac Muscle Stiffness in Adults With Marfan Syndrome", "status": "COMPLETED", "last_update": { "date": "2014-09-09", "type": "ESTIMATED" }, "primary_completion": { "date": "2012-12", "type": "ACTUAL" }, "completion": { "date": "2012-12", "type": "ACTUAL" }, "results": true, "results_posted": { "date": "2014-09-01", "type": "ESTIMATED" }, "enrollment": { "count": 40, "type": "ACTUAL" } }, { "id": "NCT00763893", "title": "Study of the Efficacy of Losartan on Aortic Dilatation in Patients With Marfan Syndrome", "status": "TERMINATED", "last_update": { "date": "2015-11-04", "type": "ESTIMATED" }, "primary_completion": { "date": "2014-01", "type": "ACTUAL" }, "completion": { "date": "2014-12", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 303, "type": "ACTUAL" } }, { "id": "NCT00782327", "title": "Randomized, Double-blind Study for the Evaluation of the Effect of Losartan Versus Placebo on Aortic Root Dilatation in Patients With Marfan Syndrome Under Treatment With Beta-blockers", "status": "COMPLETED", "last_update": { "date": "2022-12-22", "type": "ACTUAL" }, "primary_completion": { "date": "2014-11-26", "type": "ACTUAL" }, "completion": { "date": "2014-11-26", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 22, "type": "ACTUAL" } }, { "id": "NCT01145612", "title": "Atenolol Versus Losartan in the Prevention of Progressive Dilation of the Aorta in Marfan Syndrome", "status": "UNKNOWN", "last_update": { "date": "2010-08-12", "type": "ESTIMATED" }, "primary_completion": { "date": "2013-02", "type": "ESTIMATED" }, "completion": { "date": "2013-02", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 140, "type": "ACTUAL" } }, { "id": "NCT01295047", "title": "Comparison of Medical Therapies in Marfan Syndrome.", "status": "COMPLETED", "last_update": { "date": "2011-02-14", "type": "ESTIMATED" }, "primary_completion": { "date": "2007-12", "type": "ACTUAL" }, "completion": { "date": "2008-12", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 18, "type": "ACTUAL" } }, { "id": "NCT01361087", "title": "Circulating Transforming Growth Factor Beta (TGF-β) in Individuals With Marfan Syndrome", "status": "WITHDRAWN", "last_update": { "date": "2016-02-05", "type": "ESTIMATED" }, "primary_completion": { "date": "2014-12", "type": "ACTUAL" }, "completion": null, "results": false, "results_posted": null, "enrollment": { "count": 0, "type": "ACTUAL" } }, { "id": "NCT01415804", "title": "Investigation of Stent-grafts in Aortic Dissection (INSTEAD)", "status": "COMPLETED", "last_update": { "date": "2011-08-12", "type": "ESTIMATED" }, "primary_completion": { "date": "2010-10", "type": "ACTUAL" }, "completion": { "date": "2011-03", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 140, "type": "ACTUAL" } }, { "id": "NCT01715207", "title": "Comparison of Aliskiren vs Negative Controls on Aortic Stiffness in Patients With MFS", "status": "COMPLETED", "last_update": { "date": "2017-06-05", "type": "ACTUAL" }, "primary_completion": { "date": "2014-10", "type": "ACTUAL" }, "completion": { "date": "2014-12", "type": "ACTUAL" }, "results": true, "results_posted": { "date": "2017-05-04", "type": "ACTUAL" }, "enrollment": { "count": 30, "type": "ACTUAL" } }, { "id": "NCT01756833", "title": "Non-Invasive Treatment of Abdominal Aortic Aneurysm Clinical Trial", "status": "COMPLETED", "last_update": { "date": "2021-11-26", "type": "ACTUAL" }, "primary_completion": { "date": "2019-07-23", "type": "ACTUAL" }, "completion": { "date": "2019-07-23", "type": "ACTUAL" }, "results": true, "results_posted": { "date": "2021-11-26", "type": "ACTUAL" }, "enrollment": { "count": 261, "type": "ACTUAL" } }, { "id": "NCT01949233", "title": "The Oxford Marfan Trial", "status": "UNKNOWN", "last_update": { "date": "2015-06-09", "type": "ESTIMATED" }, "primary_completion": { "date": "2015-10", "type": "ESTIMATED" }, "completion": { "date": "2017-12", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 56, "type": "ESTIMATED" } }, { "id": "NCT02086136", "title": "Aortic Dissection Detection Risk Score Plus D-dimer in Suspected Acute Aortic Dissection", "status": "COMPLETED", "last_update": { "date": "2019-01-03", "type": "ACTUAL" }, "primary_completion": { "date": "2016-12", "type": "ACTUAL" }, "completion": { "date": "2016-12", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 1900, "type": "ACTUAL" } }, { "id": "NCT02201589", "title": "Feasibility of Endovascular Repair Of Ascending Aortic Pathologies", "status": "RECRUITING", "last_update": { "date": "2025-05-06", "type": "ACTUAL" }, "primary_completion": { "date": "2028-12", "type": "ESTIMATED" }, "completion": { "date": "2033-12", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 20, "type": "ESTIMATED" } }, { "id": "NCT02256163", "title": "Identification of Genes and Pathogenesis Involved in Familial Thoracic Aortic Aneurysm", "status": "COMPLETED", "last_update": { "date": "2017-11-20", "type": "ACTUAL" }, "primary_completion": { "date": "2016-12", "type": "ACTUAL" }, "completion": { "date": "2017-03", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 258, "type": "ACTUAL" } }, { "id": "NCT02299947", "title": "Bloodtranfusions After Aortic Surgery", "status": "TERMINATED", "last_update": { "date": "2019-05-10", "type": "ACTUAL" }, "primary_completion": { "date": "2018-04-26", "type": "ACTUAL" }, "completion": { "date": "2018-04-26", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 27, "type": "ACTUAL" } }, { "id": "NCT02538822", "title": "Risk of Rupture of Aneurysms of the Thoracic Ascending Aorta (ATA) From the Dynamic Imaging", "status": "TERMINATED", "last_update": { "date": "2023-05-24", "type": "ACTUAL" }, "primary_completion": { "date": "2018-09-16", "type": "ACTUAL" }, "completion": { "date": "2018-09-16", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 31, "type": "ACTUAL" } }, { "id": "NCT02724072", "title": "Thoraflex™ Hybrid IDE Study", "status": "COMPLETED", "last_update": { "date": "2022-05-16", "type": "ACTUAL" }, "primary_completion": { "date": "2019-06-24", "type": "ACTUAL" }, "completion": { "date": "2021-07-30", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 84, "type": "ACTUAL" } }, { "id": "NCT03090763", "title": "Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study \"Micro AAA\"", "status": "UNKNOWN", "last_update": { "date": "2017-03-27", "type": "ACTUAL" }, "primary_completion": { "date": "2018-05-01", "type": "ESTIMATED" }, "completion": { "date": "2019-06-01", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 200, "type": "ESTIMATED" } }, { "id": "NCT03142074", "title": "Biomechanical and Microstructural Properties of Ascending Aortic Aneurysms", "status": "UNKNOWN", "last_update": { "date": "2024-07-01", "type": "ACTUAL" }, "primary_completion": { "date": "2025-12", "type": "ESTIMATED" }, "completion": { "date": "2025-12", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 180, "type": "ESTIMATED" } }, { "id": "NCT03214601", "title": "Early Feasibility Study of the RelayBranch Thoracic Stent-Graft System", "status": "ACTIVE_NOT_RECRUITING", "last_update": { "date": "2025-05-31", "type": "ACTUAL" }, "primary_completion": { "date": "2023-09-18", "type": "ACTUAL" }, "completion": { "date": "2028-08-31", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 30, "type": "ACTUAL" } }, { "id": "NCT03322033", "title": "Feasibility of Endovascular Repair of Ascending Aortic Pathologies", "status": "TERMINATED", "last_update": { "date": "2026-03-02", "type": "ACTUAL" }, "primary_completion": { "date": "2021-10-22", "type": "ACTUAL" }, "completion": { "date": "2021-10-22", "type": "ACTUAL" }, "results": true, 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Non-diabetic AAA Patients", "status": "UNKNOWN", "last_update": { "date": "2024-03-28", "type": "ACTUAL" }, "primary_completion": { "date": "2024-05-01", "type": "ESTIMATED" }, "completion": { "date": "2024-05-01", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 170, "type": "ESTIMATED" } }, { "id": "NCT03536312", "title": "Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance", "status": "RECRUITING", "last_update": { "date": "2026-09-28", "type": "ACTUAL" }, "primary_completion": { "date": "2035-05-31", "type": "ESTIMATED" }, "completion": { "date": "2035-05-31", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 610, "type": "ESTIMATED" } }, { "id": "NCT03861741", "title": "A Study to Evaluate the Feasibility of Screening Relatives of Patients Affected by Non-Syndromic Thoracic Aortic Diseases", "status": "UNKNOWN", "last_update": { "date": "2021-05-03", "type": "ACTUAL" }, "primary_completion": { "date": "2022-05-20", "type": "ESTIMATED" }, "completion": { "date": "2022-05-20", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 70, "type": "ACTUAL" } }, { "id": "NCT04197648", "title": "Effects of Exercise on Thoracic Aneurysms", "status": "RECRUITING", "last_update": { "date": "2025-06-29", "type": "ACTUAL" }, "primary_completion": { "date": "2026-10", "type": "ESTIMATED" }, "completion": { "date": "2027-04", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 30, "type": "ESTIMATED" } }, { "id": "NCT04224051", "title": "Metformin for Abdominal Aortic Aneurysm Growth Inhibition", "status": "UNKNOWN", "last_update": { "date": "2023-09-06", "type": "ACTUAL" }, "primary_completion": { "date": "2026-01", "type": "ESTIMATED" }, "completion": { "date": "2026-01", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 500, "type": "ESTIMATED" } }, { "id": "NCT04381507", "title": "A Study in Patients with a Descending TAA or PAU Treated with the E-nya Thoracic Stent Graft System", "status": "TERMINATED", "last_update": { "date": "2024-10-18", "type": "ACTUAL" }, "primary_completion": { "date": "2024-07-24", "type": "ACTUAL" }, "completion": { "date": "2024-07-24", "type": "ACTUAL" }, "results": false, "results_posted": null, "enrollment": { "count": 1, "type": "ACTUAL" } }, { "id": "NCT04500756", "title": "Limiting AAA With Metformin (LIMIT) Trial", "status": "RECRUITING", "last_update": { "date": "2025-04-18", "type": "ACTUAL" }, "primary_completion": { "date": "2028-06-30", "type": "ESTIMATED" }, "completion": { "date": "2028-06-30", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 314, "type": "ESTIMATED" } }, { "id": "NCT04545502", "title": "PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches", "status": "RECRUITING", "last_update": { "date": "2026-08-20", "type": "ACTUAL" }, "primary_completion": { "date": "2028-08", "type": "ESTIMATED" }, "completion": { "date": "2037-01", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 2000, "type": "ESTIMATED" } }, { "id": "NCT05174767", "title": "PERSEVERE- A Trial to Evaluate AMDS in Acute DeBakey Type I Dissection", "status": "ACTIVE_NOT_RECRUITING", "last_update": { "date": "2025-01-15", "type": "ACTUAL" }, "primary_completion": { "date": "2023-12-11", "type": "ACTUAL" }, "completion": { "date": "2029-12-06", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 115, "type": "ACTUAL" } }, { "id": "NCT05215587", "title": "Scandinavian Trial of Uncomplicated Aortic Dissection Therapy", "status": "RECRUITING", "last_update": { "date": "2025-08-11", "type": "ACTUAL" }, "primary_completion": { "date": "2026-12-31", "type": "ESTIMATED" }, "completion": { "date": "2030-12-31", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 554, "type": "ESTIMATED" } }, { "id": "NCT05361772", "title": "Low-dose Colchicine Inhibit Abdominal Aortic Aneurysm Growth Trial", "status": "UNKNOWN", "last_update": { "date": "2022-05-05", "type": "ACTUAL" }, "primary_completion": { "date": "2024-06-01", "type": "ESTIMATED" }, "completion": { "date": "2025-12-31", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 230, "type": "ESTIMATED" } }, { "id": "NCT05715203", "title": "Aortic Stiffness in Patients With Genetic Aortopathies", "status": "RECRUITING", "last_update": { "date": "2025-09-10", "type": "ACTUAL" }, "primary_completion": { "date": "2025-11-30", "type": "ESTIMATED" }, "completion": { "date": "2025-12-31", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 250, "type": "ESTIMATED" } }, { "id": "NCT05800743", "title": "Evaluation of the GORE® Ascending Stent Graft", "status": "ENROLLING_BY_INVITATION", "last_update": { "date": "2026-05-29", "type": "ACTUAL" }, "primary_completion": { "date": "2029-10", "type": "ESTIMATED" }, "completion": { "date": "2034-01", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 370, "type": "ESTIMATED" } }, { "id": "NCT06044259", "title": "Study Comparing Hemiarch Replacement and Hemiarch Plus Stent Implantation in Acute Aortic Dissection", "status": "RECRUITING", "last_update": { "date": "2026-09-30", "type": "ACTUAL" }, "primary_completion": { "date": "2027-09-30", "type": "ESTIMATED" }, "completion": { "date": "2028-09-30", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 72, "type": "ESTIMATED" } }, { "id": "NCT06280482", "title": "Nicotinamide Riboside (NR) to Treat Moyamoya-like Cerebrovascular Disease in Smooth Muscle Dysfunction Syndrome (SMDS)", "status": "RECRUITING", "last_update": { "date": "2025-09-12", "type": "ACTUAL" }, "primary_completion": { "date": "2027-07-25", "type": "ESTIMATED" }, "completion": { "date": "2027-07-25", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 15, "type": "ESTIMATED" } }, { "id": "NCT06377033", "title": "Using the EHR to Advance Genomic Medicine Across a Diverse Health System", "status": "RECRUITING", "last_update": { "date": "2026-08-14", "type": "ACTUAL" }, "primary_completion": { "date": "2027-06-30", "type": "ESTIMATED" }, "completion": { "date": "2027-06-30", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 1000, "type": "ESTIMATED" } }, { "id": "NCT06550986", "title": "False Lumen Treatment for Prevention of Aortic Growth Using Shape Memory Polymer - First-in-Human Study", "status": "RECRUITING", "last_update": { "date": "2026-03-23", "type": "ACTUAL" }, "primary_completion": { "date": "2027-02-15", "type": "ESTIMATED" }, "completion": { "date": "2029-02-15", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 30, "type": "ESTIMATED" } }, { "id": "NCT06740721", "title": "False Lumen Treatment for Prevention of Aortic Growth Using Shape Memory Polymer - First-in-Human Study (FLAGSHIP_FRA)", "status": "NOT_YET_RECRUITING", "last_update": { "date": "2026-01-29", "type": "ACTUAL" }, "primary_completion": { "date": "2027-01-04", "type": "ESTIMATED" }, "completion": { "date": "2029-01-03", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 15, "type": "ESTIMATED" } }, { "id": "NCT06783803", "title": "Application of Linkage Analysis in the Identification of Novel Hereditary Factors in Familial Aneurysms", "status": "ACTIVE_NOT_RECRUITING", "last_update": { "date": "2025-01-20", "type": "ACTUAL" }, "primary_completion": { "date": "2029-05", "type": "ESTIMATED" }, "completion": { "date": "2029-06", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 20, "type": "ESTIMATED" } }, { "id": "NCT06827990", "title": "GORE® Ascending Stent Graft in the Treatment of De Novo Type A Aortic Dissections", "status": "RECRUITING", "last_update": { "date": "2026-08-11", "type": "ACTUAL" }, "primary_completion": { "date": "2030-09-01", "type": "ESTIMATED" }, "completion": { "date": "2031-09-01", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 112, "type": "ESTIMATED" } }, { "id": "NCT07034430", "title": "Aortic Dilatation Under 5 cm: Genetic Risk Mapping", "status": "ACTIVE_NOT_RECRUITING", "last_update": { "date": "2025-06-27", "type": "ACTUAL" }, "primary_completion": { "date": "2026-01-01", "type": "ESTIMATED" }, "completion": { "date": "2026-01-01", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 102, "type": "ESTIMATED" } }, { "id": "NCT07205250", "title": "Aspirin for Prevention of Stroke After Endovascular Aortic Arch Repair: a Multicenter, Double-Blind, Randomized Controlled Trial", "status": "NOT_YET_RECRUITING", "last_update": { "date": "2026-02-12", "type": "ACTUAL" }, "primary_completion": { "date": "2028-01-20", "type": "ESTIMATED" }, "completion": { "date": "2028-09-20", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 224, "type": "ESTIMATED" } }, { "id": "NCT07483177", "title": "HEART: Pilot Randomized Controlled Trial", "status": "RECRUITING", "last_update": { "date": "2026-06-08", "type": "ACTUAL" }, "primary_completion": { "date": "2028-05", "type": "ESTIMATED" }, "completion": { "date": "2028-05", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 50, "type": "ESTIMATED" } }, { "id": "NCT07495267", "title": "Nutritional Ketosis Marfan", "status": "NOT_YET_RECRUITING", "last_update": { "date": "2026-03-27", "type": "ACTUAL" }, "primary_completion": { "date": "2028-03-01", "type": "ESTIMATED" }, "completion": { "date": "2028-03-01", "type": "ESTIMATED" }, "results": false, "results_posted": null, "enrollment": { "count": 15, "type": "ESTIMATED" } } ], "registry_comparison_limit": "Recruitment status compared against existing condition text; no archived August JSON available. Results first-post dates and last-update-post dates used to check for postings or later result updates; this does not reconstruct every historical registry version.", "trial_detail_checks": { "NCT03536312": { "status": { "statusVerifiedDate": "2025-09", "overallStatus": "RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2018-09-01", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2035-05-31", "type": "ESTIMATED" }, "completionDateStruct": { "date": "2035-05-31", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2018-04-18", "studyFirstSubmitQcDate": "2018-05-14", "studyFirstPostDateStruct": { "date": "2018-05-24", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-09-24", "lastUpdatePostDateStruct": { "date": "2026-09-28", "type": "ACTUAL" } }, "outcomes": { "primaryOutcomes": [ { "measure": "All-cause mortality and incidence of acute aortic events in both surveillance and elective ascending aortic surgery groups for patients with degenerative or bicuspid valve-related ascending aortic aneurysm after 2 years of follow up.", "description": "At 2 years follow up, number of patients in surveillance versus treatment group suffering from mortality or acute aortic dissection", "timeFrame": "2 years" } ], "secondaryOutcomes": [ { "measure": "Intraoperative mortality and 30 day mortality of ascending aortic aneurysm repair", "description": "Document death during surgery or within 30 days post surgery", "timeFrame": "30 days from surgery" }, { "measure": "Incidence of need for elective ascending aortic aneurysm repair in the surveillance group", "description": "How many patients on the surveillance arm of the trial need to have surgery prior to the end of trial surveillance", "timeFrame": "2 years" }, { "measure": "Non aneurysm related death", "description": "How many patients in either surgical or surveillance arm have a non aneurysm related death", "timeFrame": "2 years" }, { "measure": "Aneurysm related death", "description": "How many patients in either the surveillance or surgical arm have an aneurysm related death", "timeFrame": "2 years" }, { "measure": "Incidence of cerebrovascular accidents (CVA)", "description": "How many patients have a CVA on the surgical or surveillance arm", "timeFrame": "2 years" }, { "measure": "Annual growth rate in diameter of ascending aortic aneurysm in the surveillance group", "description": "Prospective assessment of the rate of growth in mm/yr of moderate sized ascending aortic aneurysms", "timeFrame": "2 years" }, { "measure": "Quality of life at 1 year and 2 years for both groups", "description": "Patients will fill in questionnaires to assess impact of surveillance strategy versus surgery on quality of life", "timeFrame": "2 years" } ] }, "locations_count": 31 }, "NCT06044259": { "status": { "statusVerifiedDate": "2026-09", "overallStatus": "RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2023-10-01", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2027-09-30", "type": "ESTIMATED" }, "completionDateStruct": { "date": "2028-09-30", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2023-09-05", "studyFirstSubmitQcDate": "2023-09-16", "studyFirstPostDateStruct": { "date": "2023-09-21", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-09-27", "lastUpdatePostDateStruct": { "date": "2026-09-30", "type": "ACTUAL" } }, "outcomes": { "primaryOutcomes": [ { "measure": "Incidence of DANE", "description": "The presence of Distal Anastomosis New Entry (DANE) diagnosed by Computed Tomography in post-operative imaging within the 12-month follow-up period", "timeFrame": "At Discharge(0-14days), 30-day, 3-6 month, 12 month" } ], "secondaryOutcomes": [ { "measure": "All-cause mortality of the patients", "description": "Rate of death in the whole cohort", "timeFrame": "At discharge(0-14days), 30-day, 3-6 month, 12 month" }, { "measure": "Percentage of patient with aortic-related mortality", "description": "Percentage of patient that die from aortic related event", "timeFrame": "At Discharge(0-14days), 30-day, 3-6 month, 12 month" }, { "measure": "Percentage of patients with Major Adverse Events", "description": "Rate of patients who are free from the following Major Adverse Events (MAEs) (new permanent disabling stroke), new permanent (\\> 30 days) paraplegia or paraparesis, reintervention (excluding reoperation for bleeding or planned or unplanned additional intervention), visceral mal-perfusion, limb(s) ischemia", "timeFrame": "At Discharge(0-14days), 30-day, 3-6 month, 12 month" }, { "measure": "Percentage of patients requiring additional aortic intervention", "description": "Rate of patients with aortic rupture and additional intervention (planned / unplanned)", "timeFrame": "At Discharge(0-14days), 30-day, 3-6 month, 12 month" }, { "measure": "Percentage of patients with Renal failure", "description": "Renal failure requiring permanent (\\> 90 days) dialysis or hemofiltration in a patient with a normal pre-procedure serum creatinine level", "timeFrame": "At Discharge(0-14days), 30-day, 3-6 month, 12 month" }, { "measure": "Percentage of patients with radiological head and neck vessels patency", "description": "Radiological patency in supra-aortic head vessels (0 - 30 %, \\>30 % - 50 %, \\> 50 % - 70%, \\> 70%) (kink-, suture line-, dissection-related, other)", "timeFrame": "At Discharge(0-14days), 30-day, 3-6 month, 12 month" }, { "measure": "Percentage of patient with failure of AMDS", "description": "Failure of the integrity of the AMDS", "timeFrame": "At Discharge(0-14days), 30-day, 3-6 month, 12 month" }, { "measure": "Percentage of patients with radiological true and false lumen status of the aortic arch and descending thoracic aorta", "description": "Radiological findings of the true lumen, false lumen thrombosis", "timeFrame": "At Discharge(0-14days), 30-day, 3-6 month, 12 month" } ] }, "locations_count": 1 }, "NCT04197648": { "status": { "statusVerifiedDate": "2025-06", "overallStatus": "RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2025-06-10", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2026-10", "type": "ESTIMATED" }, "completionDateStruct": { "date": "2027-04", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2019-12-11", "studyFirstSubmitQcDate": "2019-12-12", "studyFirstPostDateStruct": { "date": "2019-12-13", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2025-06-25", "lastUpdatePostDateStruct": { "date": "2025-06-29", "type": "ACTUAL" } }, "outcomes": { "primaryOutcomes": [ { "measure": "Aneurysm diameter", "description": "Aneurysm dilation diameter is stable or comparable to control group", "timeFrame": "At 3 months of intervention" } ] }, "locations_count": 2 } }, "web_sources_checked": [ "https://professional.heart.org/en/guidelines-statements/2022-accaha-guideline-for-the-diagnosis-and-management-of-aortic-disease-acir0000000000001106", "https://professional.heart.org/en/science-news/clinical-considerations-for-competitive-sports-participation-for-athletes-with-cv-abnormalities/top-things-to-know", "https://www.escardio.org/Guidelines", "https://esvs.org/guideline/2026-dta-guidelines/", "https://www.eacts.org/?eacts-domain=aortic-disease", "https://www.vsqip.org.uk/reports-publications/", "https://ghdx.healthdata.org/gbd-2021/code/cod-2", "https://johnritterfoundation.org/aortic-dissection-awareness-week/", "https://aorticdissectionawareness.org/", "https://www.marfantrust.org/pages/82-news", "https://marfan.org/events/", "https://vascern.eu/resources/?langue=57", "https://vascern.eu/app/uploads/HTAD_Patient_Pathway_Version-2-March-26.pdf" ], "access_limits": [ "VASCERN youth-guide listing retrieved directly; linked booklet unavailable through web tool.", "Aortic Dissection Awareness UK & Ireland news headline about ESVS patient research was visible on retrieved homepage; linked detail page blocked, so not synthesised.", "PMC full-text attempts for CIRSE and sports statement failed; guidance additions limited to verified metadata/abstract and AHA official scope summary.", "No whole-condition independent audit performed; edited pages remain draft." ], "window_record_types": { "PubmedArticle": 347, "PubmedBookArticle": 1 }, "additional_excluded_record": { "pmid": "34662092", "title": "Anesthesia for Labor, Delivery, and Cesarean Section in High-Risk Heart Disease", "type": "PubmedBookArticle", "reason": "General StatPearls study guide, not new TAA evidence." } }