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        }
      }
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    {
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            },
            {
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              "to": "\"systemic\"[All Fields] OR \"systemically\"[All Fields] OR \"systemics\"[All Fields]"
            },
            {
              "from": "chemotherapy",
              "to": "\"chemotherapy's\"[All Fields] OR \"drug therapy\"[MeSH Terms] OR (\"drug\"[All Fields] AND \"therapy\"[All Fields]) OR \"drug therapy\"[All Fields] OR \"chemotherapies\"[All Fields] OR \"drug therapy\"[Subheading] OR \"chemotherapy\"[All Fields]"
            },
            {
              "from": "enucleation",
              "to": "\"enuclation\"[All Fields] OR \"enucleate\"[All Fields] OR \"enucleated\"[All Fields] OR \"enucleates\"[All Fields] OR \"enucleating\"[All Fields] OR \"enucleation\"[All Fields] OR \"enucleations\"[All Fields] OR \"enucleative\"[All Fields]"
            },
            {
              "from": "laser",
              "to": "\"laser's\"[All Fields] OR \"lasers\"[MeSH Terms] OR \"lasers\"[All Fields] OR \"laser\"[All Fields] OR \"lasered\"[All Fields] OR \"lasering\"[All Fields]"
            },
            {
              "from": "cryotherapy",
              "to": "\"cryotherapy\"[MeSH Terms] OR \"cryotherapy\"[All Fields] OR \"cryotherapies\"[All Fields]"
            },
            {
              "from": "brachytherapy",
              "to": "\"brachytherapy\"[MeSH Terms] OR \"brachytherapy\"[All Fields] OR \"brachytherapies\"[All Fields]"
            },
            {
              "from": "pathology",
              "to": "\"pathology\"[MeSH Terms] OR \"pathology\"[All Fields] OR \"pathologies\"[All Fields] OR \"pathology\"[Subheading]"
            }
          ],
          "querytranslation": "(\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]) AND (((\"systemic\"[All Fields] OR \"systemically\"[All Fields] OR \"systemics\"[All Fields]) AND (\"chemotherapy s\"[All Fields] OR \"drug therapy\"[MeSH Terms] OR (\"drug\"[All Fields] AND \"therapy\"[All Fields]) OR \"drug therapy\"[All Fields] OR \"chemotherapies\"[All Fields] OR \"drug therapy\"[MeSH Subheading] OR \"chemotherapy\"[All Fields])) OR (\"enuclation\"[All Fields] OR \"enucleate\"[All Fields] OR \"enucleated\"[All Fields] OR \"enucleates\"[All Fields] OR \"enucleating\"[All Fields] OR \"enucleation\"[All Fields] OR \"enucleations\"[All Fields] OR \"enucleative\"[All Fields]) OR (\"laser s\"[All Fields] OR \"lasers\"[MeSH Terms] OR \"lasers\"[All Fields] OR \"laser\"[All Fields] OR \"lasered\"[All Fields] OR \"lasering\"[All Fields]) OR (\"cryotherapy\"[MeSH Terms] OR \"cryotherapy\"[All Fields] OR \"cryotherapies\"[All Fields]) OR (\"brachytherapy\"[MeSH Terms] OR \"brachytherapy\"[All Fields] OR \"brachytherapies\"[All Fields]) OR (\"pathology\"[MeSH Terms] OR \"pathology\"[All Fields] OR \"pathologies\"[All Fields] OR \"pathology\"[MeSH Subheading])) AND 2026/10/24:2026/10/31[Date - Entry]"
        }
      }
    },
    {
      "topic": "systemic-focal-enucleation",
      "date_type": "pdat",
      "cochrane": true,
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      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+retinoblastoma+AND+%28systemic+chemotherapy+OR+enucleation+OR+laser+OR+cryotherapy+OR+brachytherapy+OR+pathology%29&retmode=json&mindate=2026%2F10%2F24&maxdate=2026%2F10%2F31&datetype=pdat&retmax=500",
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            },
            {
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            },
            {
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            },
            {
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            },
            {
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            },
            {
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            },
            {
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            },
            {
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              "to": "\"pathology\"[MeSH Terms] OR \"pathology\"[All Fields] OR \"pathologies\"[All Fields] OR \"pathology\"[Subheading]"
            }
          ],
          "querytranslation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]) AND (((\"systemic\"[All Fields] OR \"systemically\"[All Fields] OR \"systemics\"[All Fields]) AND (\"chemotherapy s\"[All Fields] OR \"drug therapy\"[MeSH Terms] OR (\"drug\"[All Fields] AND \"therapy\"[All Fields]) OR \"drug therapy\"[All Fields] OR \"chemotherapies\"[All Fields] OR \"drug therapy\"[MeSH Subheading] OR \"chemotherapy\"[All Fields])) OR (\"enuclation\"[All Fields] OR \"enucleate\"[All Fields] OR \"enucleated\"[All Fields] OR \"enucleates\"[All Fields] OR \"enucleating\"[All Fields] OR \"enucleation\"[All Fields] OR \"enucleations\"[All Fields] OR \"enucleative\"[All Fields]) OR (\"laser s\"[All Fields] OR \"lasers\"[MeSH Terms] OR \"lasers\"[All Fields] OR \"laser\"[All Fields] OR \"lasered\"[All Fields] OR \"lasering\"[All Fields]) OR (\"cryotherapy\"[MeSH Terms] OR \"cryotherapy\"[All Fields] OR \"cryotherapies\"[All Fields]) OR (\"brachytherapy\"[MeSH Terms] OR \"brachytherapy\"[All Fields] OR \"brachytherapies\"[All Fields]) OR (\"pathology\"[MeSH Terms] OR \"pathology\"[All Fields] OR \"pathologies\"[All Fields] OR \"pathology\"[MeSH Subheading])) AND 2026/10/24:2026/10/31[Date - Publication]",
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            "outputmessages": [
              "No items found."
            ]
          }
        }
      }
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    {
      "topic": "local-chemotherapy",
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      "query": "retinoblastoma AND (intra-arterial OR intravitreal OR intracameral OR topotecan OR melphalan)",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=retinoblastoma+AND+%28intra-arterial+OR+intravitreal+OR+intracameral+OR+topotecan+OR+melphalan%29&retmode=json&mindate=2026%2F10%2F24&maxdate=2026%2F10%2F31&datetype=pdat&retmax=500",
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        "esearchresult": {
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          "idlist": [],
          "translationset": [
            {
              "from": "retinoblastoma",
              "to": "\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]"
            },
            {
              "from": "intravitreal",
              "to": "\"intravitral\"[All Fields] OR \"intravitreal\"[All Fields] OR \"intravitreally\"[All Fields] OR \"intravitreous\"[All Fields] OR \"intravitreously\"[All Fields]"
            },
            {
              "from": "intracameral",
              "to": "\"intracameral\"[All Fields] OR \"intracamerally\"[All Fields]"
            },
            {
              "from": "topotecan",
              "to": "\"topotecan\"[Supplementary Concept] OR \"topotecan\"[All Fields] OR \"topotecan\"[MeSH Terms] OR \"topotecan's\"[All Fields]"
            },
            {
              "from": "melphalan",
              "to": "\"melphalan\"[Supplementary Concept] OR \"melphalan\"[All Fields] OR \"melphalan\"[MeSH Terms]"
            }
          ],
          "querytranslation": "(\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]) AND (\"intra-arterial\"[All Fields] OR (\"intravitral\"[All Fields] OR \"intravitreal\"[All Fields] OR \"intravitreally\"[All Fields] OR \"intravitreous\"[All Fields] OR \"intravitreously\"[All Fields]) OR (\"intracameral\"[All Fields] OR \"intracamerally\"[All Fields]) OR (\"topotecan\"[Supplementary Concept] OR \"topotecan\"[All Fields] OR \"topotecan\"[MeSH Terms]) OR (\"melphalan\"[Supplementary Concept] OR \"melphalan\"[All Fields] OR \"melphalan\"[MeSH Terms])) AND 2026/10/24:2026/10/31[Date - Publication]",
          "warninglist": {
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              "No items found."
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        }
      }
    },
    {
      "topic": "local-chemotherapy",
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      "query": "retinoblastoma AND (intra-arterial OR intravitreal OR intracameral OR topotecan OR melphalan)",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=retinoblastoma+AND+%28intra-arterial+OR+intravitreal+OR+intracameral+OR+topotecan+OR+melphalan%29&retmode=json&mindate=2026%2F10%2F24&maxdate=2026%2F10%2F31&datetype=edat&retmax=500",
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            },
            {
              "from": "intravitreal",
              "to": "\"intravitral\"[All Fields] OR \"intravitreal\"[All Fields] OR \"intravitreally\"[All Fields] OR \"intravitreous\"[All Fields] OR \"intravitreously\"[All Fields]"
            },
            {
              "from": "intracameral",
              "to": "\"intracameral\"[All Fields] OR \"intracamerally\"[All Fields]"
            },
            {
              "from": "topotecan",
              "to": "\"topotecan\"[Supplementary Concept] OR \"topotecan\"[All Fields] OR \"topotecan\"[MeSH Terms] OR \"topotecan's\"[All Fields]"
            },
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            }
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          "querytranslation": "(\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]) AND (\"intra-arterial\"[All Fields] OR (\"intravitral\"[All Fields] OR \"intravitreal\"[All Fields] OR \"intravitreally\"[All Fields] OR \"intravitreous\"[All Fields] OR \"intravitreously\"[All Fields]) OR (\"intracameral\"[All Fields] OR \"intracamerally\"[All Fields]) OR (\"topotecan\"[Supplementary Concept] OR \"topotecan\"[All Fields] OR \"topotecan\"[MeSH Terms]) OR (\"melphalan\"[Supplementary Concept] OR \"melphalan\"[All Fields] OR \"melphalan\"[MeSH Terms])) AND 2026/10/24:2026/10/31[Date - Entry]"
        }
      }
    },
    {
      "topic": "local-chemotherapy",
      "date_type": "pdat",
      "cochrane": true,
      "query": "\"Cochrane Database Syst Rev\"[jour] AND retinoblastoma AND (intra-arterial OR intravitreal OR intracameral OR topotecan OR melphalan)",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+retinoblastoma+AND+%28intra-arterial+OR+intravitreal+OR+intracameral+OR+topotecan+OR+melphalan%29&retmode=json&mindate=2026%2F10%2F24&maxdate=2026%2F10%2F31&datetype=pdat&retmax=500",
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            {
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              "to": "\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]"
            },
            {
              "from": "intravitreal",
              "to": "\"intravitral\"[All Fields] OR \"intravitreal\"[All Fields] OR \"intravitreally\"[All Fields] OR \"intravitreous\"[All Fields] OR \"intravitreously\"[All Fields]"
            },
            {
              "from": "intracameral",
              "to": "\"intracameral\"[All Fields] OR \"intracamerally\"[All Fields]"
            },
            {
              "from": "topotecan",
              "to": "\"topotecan\"[Supplementary Concept] OR \"topotecan\"[All Fields] OR \"topotecan\"[MeSH Terms] OR \"topotecan's\"[All Fields]"
            },
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              "from": "melphalan",
              "to": "\"melphalan\"[Supplementary Concept] OR \"melphalan\"[All Fields] OR \"melphalan\"[MeSH Terms]"
            }
          ],
          "querytranslation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]) AND (\"intra-arterial\"[All Fields] OR (\"intravitral\"[All Fields] OR \"intravitreal\"[All Fields] OR \"intravitreally\"[All Fields] OR \"intravitreous\"[All Fields] OR \"intravitreously\"[All Fields]) OR (\"intracameral\"[All Fields] OR \"intracamerally\"[All Fields]) OR (\"topotecan\"[Supplementary Concept] OR \"topotecan\"[All Fields] OR \"topotecan\"[MeSH Terms]) OR (\"melphalan\"[Supplementary Concept] OR \"melphalan\"[All Fields] OR \"melphalan\"[MeSH Terms])) AND 2026/10/24:2026/10/31[Date - Publication]",
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          }
        }
      }
    },
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      "topic": "extraocular-trilateral",
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      "query": "retinoblastoma AND (extraocular OR metastatic OR trilateral OR optic nerve)",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=retinoblastoma+AND+%28extraocular+OR+metastatic+OR+trilateral+OR+optic+nerve%29&retmode=json&mindate=2026%2F10%2F24&maxdate=2026%2F10%2F31&datetype=pdat&retmax=500",
      "response": {
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            {
              "from": "retinoblastoma",
              "to": "\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]"
            },
            {
              "from": "metastatic",
              "to": "\"metastatically\"[All Fields] OR \"metastatics\"[All Fields] OR \"metastatization\"[All Fields] OR \"metastatize\"[All Fields] OR \"metastatized\"[All Fields] OR \"metastatizing\"[All Fields] OR \"secondary\"[Subheading] OR \"secondary\"[All Fields] OR \"metastatic\"[All Fields]"
            },
            {
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              "to": "\"optic nerve\"[MeSH Terms] OR (\"optic\"[All Fields] AND \"nerve\"[All Fields]) OR \"optic nerve\"[All Fields]"
            }
          ],
          "querytranslation": "(\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]) AND (\"extraocular\"[All Fields] OR (\"metastatically\"[All Fields] OR \"metastatics\"[All Fields] OR \"metastatization\"[All Fields] OR \"metastatize\"[All Fields] OR \"metastatized\"[All Fields] OR \"metastatizing\"[All Fields] OR \"secondary\"[MeSH Subheading] OR \"secondary\"[All Fields] OR \"metastatic\"[All Fields]) OR \"trilateral\"[All Fields] OR (\"optic nerve\"[MeSH Terms] OR (\"optic\"[All Fields] AND \"nerve\"[All Fields]) OR \"optic nerve\"[All Fields])) AND 2026/10/24:2026/10/31[Date - Publication]"
        }
      }
    },
    {
      "topic": "extraocular-trilateral",
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      "query": "retinoblastoma AND (extraocular OR metastatic OR trilateral OR optic nerve)",
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            "42922212"
          ],
          "translationset": [
            {
              "from": "retinoblastoma",
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            },
            {
              "from": "metastatic",
              "to": "\"metastatically\"[All Fields] OR \"metastatics\"[All Fields] OR \"metastatization\"[All Fields] OR \"metastatize\"[All Fields] OR \"metastatized\"[All Fields] OR \"metastatizing\"[All Fields] OR \"secondary\"[Subheading] OR \"secondary\"[All Fields] OR \"metastatic\"[All Fields]"
            },
            {
              "from": "optic nerve",
              "to": "\"optic nerve\"[MeSH Terms] OR (\"optic\"[All Fields] AND \"nerve\"[All Fields]) OR \"optic nerve\"[All Fields]"
            }
          ],
          "querytranslation": "(\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]) AND (\"extraocular\"[All Fields] OR (\"metastatically\"[All Fields] OR \"metastatics\"[All Fields] OR \"metastatization\"[All Fields] OR \"metastatize\"[All Fields] OR \"metastatized\"[All Fields] OR \"metastatizing\"[All Fields] OR \"secondary\"[MeSH Subheading] OR \"secondary\"[All Fields] OR \"metastatic\"[All Fields]) OR \"trilateral\"[All Fields] OR (\"optic nerve\"[MeSH Terms] OR (\"optic\"[All Fields] AND \"nerve\"[All Fields]) OR \"optic nerve\"[All Fields])) AND 2026/10/24:2026/10/31[Date - Entry]"
        }
      }
    },
    {
      "topic": "extraocular-trilateral",
      "date_type": "pdat",
      "cochrane": true,
      "query": "\"Cochrane Database Syst Rev\"[jour] AND retinoblastoma AND (extraocular OR metastatic OR trilateral OR optic nerve)",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+retinoblastoma+AND+%28extraocular+OR+metastatic+OR+trilateral+OR+optic+nerve%29&retmode=json&mindate=2026%2F10%2F24&maxdate=2026%2F10%2F31&datetype=pdat&retmax=500",
      "response": {
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          "idlist": [],
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            {
              "from": "retinoblastoma",
              "to": "\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]"
            },
            {
              "from": "metastatic",
              "to": "\"metastatically\"[All Fields] OR \"metastatics\"[All Fields] OR \"metastatization\"[All Fields] OR \"metastatize\"[All Fields] OR \"metastatized\"[All Fields] OR \"metastatizing\"[All Fields] OR \"secondary\"[Subheading] OR \"secondary\"[All Fields] OR \"metastatic\"[All Fields]"
            },
            {
              "from": "optic nerve",
              "to": "\"optic nerve\"[MeSH Terms] OR (\"optic\"[All Fields] AND \"nerve\"[All Fields]) OR \"optic nerve\"[All Fields]"
            }
          ],
          "querytranslation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]) AND (\"extraocular\"[All Fields] OR (\"metastatically\"[All Fields] OR \"metastatics\"[All Fields] OR \"metastatization\"[All Fields] OR \"metastatize\"[All Fields] OR \"metastatized\"[All Fields] OR \"metastatizing\"[All Fields] OR \"secondary\"[MeSH Subheading] OR \"secondary\"[All Fields] OR \"metastatic\"[All Fields]) OR \"trilateral\"[All Fields] OR (\"optic nerve\"[MeSH Terms] OR (\"optic\"[All Fields] AND \"nerve\"[All Fields]) OR \"optic nerve\"[All Fields])) AND 2026/10/24:2026/10/31[Date - Publication]",
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            ]
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        }
      }
    },
    {
      "topic": "survivorship-vision",
      "date_type": "pdat",
      "query": "retinoblastoma AND (second cancer OR subsequent neoplasm OR survivorship OR vision OR quality of life)",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=retinoblastoma+AND+%28second+cancer+OR+subsequent+neoplasm+OR+survivorship+OR+vision+OR+quality+of+life%29&retmode=json&mindate=2026%2F10%2F24&maxdate=2026%2F10%2F31&datetype=pdat&retmax=500",
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        "esearchresult": {
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          "idlist": [
            "42951099"
          ],
          "translationset": [
            {
              "from": "retinoblastoma",
              "to": "\"retinoblastoma\"[MeSH Terms] OR \"retinoblastoma\"[All Fields] OR \"retinoblastomas\"[All Fields]"
            },
            {
              "from": "second cancer",
              "to": "\"neoplasms, second primary\"[MeSH Terms] OR (\"neoplasms\"[All Fields] AND \"second\"[All Fields] AND \"primary\"[All Fields]) OR \"second primary neoplasms\"[All Fields] OR (\"second\"[All Fields] AND \"cancer\"[All Fields]) OR \"second cancer\"[All Fields]"
            },
            {
              "from": "subsequent",
              "to": "\"subsequent\"[All Fields] OR \"subsequently\"[All Fields]"
            },
            {
              "from": "neoplasm",
              "to": "\"neoplasm's\"[All Fields] OR \"neoplasms\"[MeSH Terms] OR \"neoplasms\"[All Fields] OR \"neoplasm\"[All Fields]"
            },
            {
              "from": "survivorship",
              "to": "\"survivorship\"[MeSH Terms] OR \"survivorship\"[All Fields] OR \"survivorships\"[All Fields]"
            },
            {
              "from": "vision",
              "to": "\"vision's\"[All Fields] OR \"vision, ocular\"[MeSH Terms] OR (\"vision\"[All Fields] AND \"ocular\"[All Fields]) OR \"ocular vision\"[All Fields] OR \"vision\"[All Fields] OR \"visions\"[All Fields] OR \"visioning\"[All Fields]"
            },
            {
              "from": "quality of life",
              "to": "\"quality of life\"[MeSH Terms] OR (\"quality\"[All Fields] AND \"life\"[All Fields]) OR \"quality of life\"[All Fields]"
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        }
      }
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        }
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        }
      }
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    {
      "topic": "access-patient-experience",
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      "query": "retinoblastoma AND (delay OR abandonment OR access OR disparity OR family OR patient experience)",
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            {
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        "title": "The evaluation of safety and biological effects of cancer-killing virus vaccine given to patients with advanced brain tumours",
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        "recruitment_end": "2027-09-30T00:00:00.000Z"
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      "name": "isrctn",
      "url": "https://www.isrctn.com/api/studies?q=retinoblastoma&format=json",
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    {
      "name": "isrctn2",
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      "http_status": 200,
      "final_url": "https://wechope.org/blog/",
      "bytes": 201437,
      "status": "HTTP 200 direct HTML; datePublished 2026-10-26 found; cached web-tool listing was older"
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      "http_status": 200,
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      "status": "retrieved via web tool; correct Canadian organization domain"
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    {
      "url": "https://www.rbsociety.ca/events",
      "status": "retrieved via web tool; October 15 event and November date-TBD eye-loss meetup, no new in-window date identified"
    },
    {
      "url": "https://www.rbsociety.ca/news",
      "status": "web tool cache miss"
    },
    {
      "url": "https://cankidsindia.org/retinoblastoma/",
      "status": "retrieved via web tool; correct live path"
    },
    {
      "url": "https://chect.org.uk/blog/",
      "status": "retrieved via homepage link; correct stories/news path"
    },
    {
      "url": "https://www.aaojournal.org/article/S0161-6420(26)00694-9/fulltext",
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      "status": "HTTP 200 browser-check/reCAPTCHA page, not article body"
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      "status": "HTML redirects to JS/cookie holding page; XML API succeeded"
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    "site.rcophth.ac.uk retinoblastoma guideline 2026",
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      "Europe PMC epidemiology-burden queries",
      "https://map.1rbw.org/"
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      "source": "SciELO and LILACS",
      "reason": "unavailable / HTTP 403 per SOURCES.md; not searched; no regional absence claim"
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    {
      "source": "WHO ICTRP",
      "reason": "programmatic search not established; named ISRCTN registry queried directly instead"
    },
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      "source": "Unpaywall",
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    {
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      "triage": "bibliography only; full text unavailable via Europe PMC, no numerical wiki/statistics claim"
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      "reason": "Potentially useful prospective secondary OAC cohort, newly indexed; Crossref DOI endpoint 404 in both case forms and title search failed to match. Retraction verification incomplete, so held out of bibliography/wiki."
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    {
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      "reason": "Small exploratory MTHFR candidate-gene association; no practice-changing evidence."
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    {
      "pmid": "42959403",
      "reason": "Columbianadin TOP2A/PI3K-AKT preclinical study; no clinical implication promoted."
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    {
      "pmid": "42959906",
      "reason": "Single atypical adult retinocytoma transformation case; no general diagnostic or biopsy-safety recommendation inferred."
    },
    {
      "pmid": "42920479",
      "reason": "Mixed-cancer displaced-patient cohort; no pooled survival/burden statistic transferred to retinoblastoma."
    },
    {
      "pmid": "42925475",
      "reason": "Off-topic RB/pRB pathway or general ocular tissue-engineering match"
    },
    {
      "pmid": "42931222",
      "reason": "Off-topic RB/pRB pathway or general ocular tissue-engineering match"
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      "reason": "Off-topic RB/pRB pathway or general ocular tissue-engineering match"
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      "reason": "Off-topic RB/pRB pathway or general ocular tissue-engineering match"
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      "reason": "Off-topic RB/pRB pathway or general ocular tissue-engineering match"
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      "reason": "Off-topic RB/pRB pathway or general ocular tissue-engineering match"
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      "reason": "GBD-related preprint; DOI resolved with Crossref, not peer reviewed; no numerical burden or causal claim promoted"
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      "reason": "GBD-related preprint; DOI resolved with Crossref, not peer reviewed; no numerical burden or causal claim promoted"
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            "title": "Chemoreduction for retinoblastoma may prevent trilateral retinoblastoma.",
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            "title": "Postenucleation adjuvant therapy in high-risk retinoblastoma.",
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            "title": "Chemoreduction for unilateral retinoblastoma.",
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            "title": "Histopathologic findings in eyes with retinoblastoma treated only with chemoreduction.",
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            "title": "Extraocular retinoblastoma: a 13-year experience.",
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            "title": "[Retinoblastoma].",
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            "title": "Retinoblastoma associated with chromosomal 13q14 deletion mosaicism.",
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            "title": "Transpupillary thermotherapy as initial treatment for small intraocular retinoblastoma: technique and predictors of success.",
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            "pmid": "15136321",
            "title": "Practical approach to management of retinoblastoma.",
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            "title": "Retinoblastoma patients with high risk ocular pathological features: who needs adjuvant therapy?",
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            "title": "Causes of chemoreduction failure in retinoblastoma and analysis of associated factors leading to eventual treatment with external beam radiotherapy and enucleation.",
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            "title": "Chemotherapy for retinoblastoma.",
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            "title": "Chemoreduction in the management of retinoblastoma.",
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            "title": "Trilateral retinoblastoma.",
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            "title": "Survival in extra-orbital metastatic retinoblastoma:treatment results.",
            "publication_date": "2006 Jan"
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            "title": "Treatment of retinoblastoma patients with chemoreduction plus local therapy: experience of the AC Camargo Hospital, Brazil.",
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            "publication_date": "2007 Jan-Feb"
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            "title": "Retinoblastoma epidemiology: does the evidence matter?",
            "publication_date": "2007 Jul"
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          {
            "pmid": "17729249",
            "title": "Outcomes of a two-drug chemotherapy regimen for intraocular retinoblastoma.",
            "publication_date": "2008 Mar"
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          {
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            "title": "Diffuse infiltrating retinoblastoma.",
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            "pmid": "18762512",
            "title": "Retinoblastoma: one world, one vision.",
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          {
            "pmid": "18937327",
            "title": "Treatment results in patients with retinoblastoma and invasion to the cut end of the optic nerve.",
            "publication_date": "2009 Feb"
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          {
            "pmid": "19184307",
            "title": "Prognostic factors and treatment outcomes of retinoblastoma in pediatric patients: a single-institution study.",
            "publication_date": "2009 Jan"
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          {
            "pmid": "19351917",
            "title": "Cause-specific mortality in long-term survivors of retinoblastoma.",
            "publication_date": "2009 Apr 15"
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          {
            "pmid": "19477707",
            "title": "Frontiers in the management of retinoblastoma.",
            "publication_date": "2009 Aug"
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          {
            "pmid": "20224400",
            "title": "Retinoblastoma management: advances in enucleation, intravenous chemoreduction, and intra-arterial chemotherapy.",
            "publication_date": "2010 May"
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          {
            "pmid": "20381868",
            "title": "Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma (chemosurgery).",
            "publication_date": "2010 Aug"
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          {
            "pmid": "2059954",
            "title": "Retinoblastoma.",
            "publication_date": "1991 Jun"
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          {
            "pmid": "20679076",
            "title": "Challenging the global retinoblastoma survival disparity through a collaborative research effort.",
            "publication_date": "2010 Nov"
          },
          {
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            "title": "Retinoblastoma.",
            "publication_date": "2010"
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          {
            "pmid": "20714385",
            "title": "Eye-preserving therapy in retinoblastoma: prolonged primary chemotherapy alone or combined with local therapy.",
            "publication_date": "2010 Aug"
          },
          {
            "pmid": "21320950",
            "title": "Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience.",
            "publication_date": "2011 Jun"
          },
          {
            "pmid": "21364467",
            "title": "Bone marrow aspirations and lumbar punctures in retinoblastoma at diagnosis: correlation with IRSS staging.",
            "publication_date": "2011 Jul"
          },
          {
            "pmid": "21546735",
            "title": "Orbital retinoblastoma: where do we go from here?",
            "publication_date": "2011 Jan-Mar"
          },
          {
            "pmid": "21721113",
            "title": "Clinical predictors of high risk histopathology in retinoblastoma.",
            "publication_date": "2012 Mar"
          },
          {
            "pmid": "21849363",
            "title": "MRI of retinoblastoma.",
            "publication_date": "2011 Sep"
          },
          {
            "pmid": "22106703",
            "title": "Trilateral retinoblastoma.",
            "publication_date": "2011 Jun"
          },
          {
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    "published": "2026-10-26",
    "accessed": "2026-10-31",
    "triage": "Patient-voice sources/themes only: care coordination, survivor/prosthesis experience and lived-experience input to a consequence score. No clinical efficacy or score-validation claim.",
    "verification": "Direct HTML listing publication timestamps were checked against the raw response, then the article body was read. The web-tool cached listing omitted the post; the raw listing excerpt refers to Hawaii rather than the San Antonio meeting described in the body. No attendance numbers or private identities were extracted."
  },
  "validation": {
    "frontmatter_dates_and_draft_status": "passed",
    "all_edited_markdown_pmids_retrieved_in_session": 387,
    "new_papers_pubmed_and_crossref_retraction_checks": "passed",
    "bibliography_wiki_index_counts": "passed",
    "all_wiki_ncts_live_checked": 20,
    "complete_condition_registry_records": 140,
    "public_builder_manifest_mapping_and_transformed_local_links": "passed",
    "full_mkdocs_strict_build": "not run: MkDocs not installed in available Python environment",
    "independent_audit": "pending"
  }
}
