{ "date": "2026-10-22", "condition": "osteoarthritis", "date_from": "2026-08-28", "date_to": "2026-10-22", "author": "Codex; independent different-engine audit pending", "pubmed_eutilities": { "overall_cochrane": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "overall_cochrane_edat": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND 2026/08/28:2026/10/22[edat]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND 2026/08/28:2026/10/22[Date - Entry]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "guidelines": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (guideline[pt] OR practice guideline[pt] OR guideline*[ti] OR recommendation*[ti] OR consensus[ti]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"guideline*\"[Title] OR \"recommendation*\"[Title] OR \"consensus\"[Title]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 20, "ids": [ "42886825", "42880894", "42838839", "42825586", "42825585", "42809374", "42802502", "42749319", "42701879", "42699140", "42683462", "42683154", "42645742", "42520131", "42487072", "42284853", "41742784", "41688056", "41524479", "40156368" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "epidemiology_burden": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (\"global burden\"[tiab] OR GBD[tiab] OR prevalence[ti] OR incidence[ti] OR burden[ti]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"global burden\"[Title/Abstract] OR \"GBD\"[Title/Abstract] OR \"prevalence\"[Title] OR \"incidence\"[Title] OR \"burden\"[Title]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 40, "ids": [ "42895623", "42892730", "42881938", "42877324", "42868005", "42866781", "42857454", "42841006", "42839719", "42814176", "42813150", "42809099", "42808667", "42798306", "42770731", "42744301", "42743872", "42739905", "42733749", "42732557", "42724153", "42714341", "42709298", "42703347", "42701772", "42695435", "42683688", "42679988", "42676605", "42637997", "42633461", "42420572", "42348175", "42283064", "42229783", "42202493", "41862128", "41833786", "41830395", "41786667" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "diagnosis_classification": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (classification criteria[tiab] OR diagnos*[ti] OR phenotyp*[ti] OR \"early osteoarthritis\"[tiab]) AND (systematic review[pt] OR meta-analysis[pt] OR validation[ti] OR cohort[ti]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"classification criteria\"[Title/Abstract] OR \"diagnos*\"[Title] OR \"phenotyp*\"[Title] OR \"early osteoarthritis\"[Title/Abstract]) AND (\"systematic review\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"validation\"[Title] OR \"cohort\"[Title]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 6, "ids": [ "42892376", "42620719", "42461107", "42220330", "41455026", "41049827" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "biology": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (cartilage[ti] OR chondrocyte*[ti] OR synovi*[ti] OR subchondral[ti]) AND (human[mh] OR patients[tiab]) AND (review[pt] OR \"single-cell\"[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"cartilage\"[Title] OR \"chondrocyte*\"[Title] OR \"synovi*\"[Title] OR \"subchondral\"[Title]) AND (\"humans\"[MeSH Terms] OR \"patients\"[Title/Abstract]) AND (\"review\"[Publication Type] OR \"single-cell\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 33, "ids": [ "42889345", "42883797", "42881169", "42871533", "42862839", "42860389", "42825366", "42811796", "42810572", "42802793", "42801095", "42794637", "42791918", "42761519", "42757661", "42757457", "42750991", "42743060", "42740997", "42729817", "42725850", "42692563", "42679564", "42636292", "42598988", "42492727", "42474670", "42431012", "42218983", "42189913", "42128266", "41921008", "39291443" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "pain_mechanisms": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (sensitization[tiab] OR sensitisation[tiab] OR nociplastic[tiab] OR \"pain mechanism*\"[tiab] OR neuropathic[ti]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"sensitization\"[Title/Abstract] OR \"sensitisation\"[Title/Abstract] OR \"nociplastic\"[Title/Abstract] OR \"pain mechanism*\"[Title/Abstract] OR \"neuropathic\"[Title]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 38, "ids": [ "42898890", "42898712", "42888265", "42885467", "42884570", "42883797", "42876321", "42857293", "42857188", "42853345", "42840734", "42828189", "42820961", "42782280", "42770731", "42769256", "42766569", "42761406", "42759264", "42755904", "42750991", "42750572", "42739852", "42736980", "42733314", "42714824", "42709140", "42707081", "42668447", "42667441", "42645742", "42635964", "42606637", "42531924", "42467092", "42387158", "42383284", "42349541" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "genetics_risk": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (GWAS[tiab] OR genome-wide[tiab] OR \"mendelian randomization\"[tiab] OR polygenic[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"GWAS\"[Title/Abstract] OR \"genome-wide\"[Title/Abstract] OR \"mendelian randomization\"[Title/Abstract] OR \"polygenic\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 23, "ids": [ "42861094", "42855042", "42794810", "42792836", "42772042", "42770026", "42762435", "42759090", "42722059", "42687813", "42675719", "42671689", "42671508", "42662567", "42656980", "42606104", "42520998", "42375819", "42322815", "42285256", "42269982", "42110225", "41972844" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "exercise_weight_selfmgmt": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (exercise[ti] OR \"weight loss\"[tiab] OR education[ti] OR self-management[tiab] OR physiotherap*[ti]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"exercise\"[Title] OR \"weight loss\"[Title/Abstract] OR \"education\"[Title] OR \"self-management\"[Title/Abstract] OR \"physiotherap*\"[Title]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 23, "ids": [ "42888606", "42885413", "42876545", "42775508", "42772870", "42730869", "42715249", "42714961", "42703695", "42676087", "42628475", "42623907", "42579894", "42407202", "42373005", "42366407", "42241894", "41802622", "41742784", "41736456", "41723580", "41706544", "41505342" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "glp1_incretin": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (semaglutide[tiab] OR tirzepatide[tiab] OR GLP-1[tiab] OR \"glucagon-like peptide\"[tiab] OR incretin[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"semaglutide\"[Title/Abstract] OR \"tirzepatide\"[Title/Abstract] OR \"GLP-1\"[Title/Abstract] OR \"glucagon-like peptide\"[Title/Abstract] OR \"incretin\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 29, "ids": [ "42896210", "42896209", "42896208", "42890326", "42884570", "42878727", "42875481", "42856009", "42827061", "42814954", "42810372", "42778434", "42772870", "42767324", "42754765", "42747716", "42730869", "42706128", "42692567", "42479349", "42463065", "42448219", "42444567", "42412371", "42348175", "42321007", "42274387", "42225263", "42107588" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "pharmacologic": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (NSAID*[tiab] OR \"anti-inflammatory agents, non-steroidal\"[mh] OR acetaminophen[tiab] OR paracetamol[tiab] OR duloxetine[tiab] OR opioid*[tiab] OR tramadol[tiab] OR topical[ti]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"nsaid*\"[Title/Abstract] OR \"anti inflammatory agents, non steroidal\"[MeSH Terms] OR \"acetaminophen\"[Title/Abstract] OR \"paracetamol\"[Title/Abstract] OR \"duloxetine\"[Title/Abstract] OR \"opioid*\"[Title/Abstract] OR \"tramadol\"[Title/Abstract] OR \"topical\"[Title]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 8, "ids": [ "42733221", "42730321", "42714961", "42679472", "42674575", "42544937", "42036080", "41461068" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "injections_orthobiologics": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (intra-articular[tiab] OR corticosteroid*[tiab] OR triamcinolone[tiab] OR hyaluron*[tiab] OR \"platelet-rich plasma\"[tiab] OR PRP[tiab] OR \"stem cell*\"[tiab] OR mesenchymal[tiab] OR \"genicular\"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"intra-articular\"[Title/Abstract] OR \"corticosteroid*\"[Title/Abstract] OR \"triamcinolone\"[Title/Abstract] OR \"hyaluron*\"[Title/Abstract] OR \"platelet-rich plasma\"[Title/Abstract] OR \"PRP\"[Title/Abstract] OR \"stem cell*\"[Title/Abstract] OR \"mesenchymal\"[Title/Abstract] OR \"genicular\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 18, "ids": [ "42804311", "42671292", "42585691", "42524752", "42424755", "42371012", "42303879", "42302358", "42214487", "42208168", "42101047", "42055224", "42036080", "41766056", "41760441", "41685775", "41514058", "41496305" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "surgery_arthroplasty": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (arthroplasty[tiab] OR replacement[ti] OR osteotomy[tiab] OR arthroscop*[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"arthroplasty\"[Title/Abstract] OR \"replacement\"[Title] OR \"osteotomy\"[Title/Abstract] OR \"arthroscop*\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 31, "ids": [ "42804311", "42803050", "42789133", "42786446", "42778252", "42775510", "42770474", "42770473", "42730321", "42721566", "42714169", "42674575", "42624811", "42526367", "42360437", "42235618", "42203123", "42106084", "42055224", "42055222", "42036090", "42036086", "42036080", "42025190", "42002253", "41966468", "41934738", "41862142", "41862128", "41786669", "41461068" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "dmoad": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (disease-modifying[tiab] OR DMOAD*[tiab] OR sprifermin[tiab] OR lorecivivint[tiab] OR tanezumab[tiab] OR \"anti-NGF\"[tiab] OR \"nerve growth factor\"[tiab] OR ADAMTS*[tiab] OR \"structure modif*\"[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"disease-modifying\"[Title/Abstract] OR \"dmoad*\"[Title/Abstract] OR \"sprifermin\"[Title/Abstract] OR \"lorecivivint\"[Title/Abstract] OR \"tanezumab\"[Title/Abstract] OR \"anti-NGF\"[Title/Abstract] OR \"nerve growth factor\"[Title/Abstract] OR \"adamts*\"[Title/Abstract] OR \"structure modif*\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 128, "ids": [ "42898573", "42897005", "42896771", "42896357", "42892544", "42889420", "42885466", "42883797", "42880554", "42879521", "42876321", "42875481", "42872559", "42871198", "42866276", "42863418", "42860389", "42859083", "42858199", "42856009", "42855042", "42852532", "42851919", "42851900", "42851840", "42850492", "42849669", "42849031", "42844420", "42840734", "42838868", "42835324", "42828821", "42828757", "42828279", "42826836", "42815820", "42814102", "42808736", "42803147", "42800293", "42798654", "42792871", "42792836", "42792765", "42791579", "42790833", "42789011", "42784800", "42779961", "42778434", "42767324", "42766346", "42761062", "42760593", "42756019", "42755648", "42753488", "42752667", "42750991", "42750882", "42750165", "42747754", "42747683", "42742542", "42741701", "42741686", "42741326", "42737766", "42736683", "42736608", "42734458", "42733614", "42733560", "42733189", "42731244", "42729156", "42727834", "42725850", "42725019", "42722058", "42716128", "42714824", "42714638", "42711652", "42706131", "42700728", "42695436", "42695425", "42692566", "42692565", "42692564", "42692563", "42686975", "42685748", "42679542", "42677991", "42675744", "42674568", "42673999", "42635964", "42633565", "42632308", "42621400", "42602932", "42601565", "42584803", "42573179", "42564586", "42554227", "42479819", "42471867", "42468167", "42435424", "42431012", "42410245", "42400930", "42391815", "42381420", "42322814", "42297245", "42284507", "42269982", "42176879", "42138236", "41386507", "40553578", "39291443" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "biomarkers_imaging": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (biomarker*[ti] OR MRI[ti] OR \"magnetic resonance\"[ti] OR radiograph*[ti] OR \"artificial intelligence\"[tiab] OR \"deep learning\"[tiab]) AND (cohort[tiab] OR validation[tiab] OR systematic review[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"biomarker*\"[Title] OR \"MRI\"[Title] OR \"magnetic resonance\"[Title] OR \"radiograph*\"[Title] OR \"artificial intelligence\"[Title/Abstract] OR \"deep learning\"[Title/Abstract]) AND (\"cohort\"[Title/Abstract] OR \"validation\"[Title/Abstract] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 68, "ids": [ "42901990", "42884008", "42879167", "42877285", "42876081", "42870426", "42870156", "42858765", "42851913", "42851900", "42845196", "42833978", "42833930", "42830692", "42817870", "42817401", "42815430", "42812297", "42810402", "42802793", "42792832", "42786113", "42782519", "42781773", "42768777", "42763426", "42762162", "42761148", "42759284", "42757717", "42741032", "42739905", "42736660", "42731810", "42726790", "42726694", "42718991", "42709577", "42684455", "42680660", "42678533", "42677189", "42675516", "42675124", "42674311", "42667212", "42664217", "42661521", "42628251", "42622946", "42615942", "42605235", "42605018", "42584803", "42479819", "42467093", "42461107", "42376176", "42331136", "42264324", "42259405", "42247863", "42173234", "42092467", "42069776", "41991116", "41049827", "40757956" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "trials_phase3": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (randomized controlled trial[pt]) AND (\"phase 3\"[tiab] OR \"phase III\"[tiab] OR multicent*[tiab] OR placebo[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND \"randomized controlled trial\"[Publication Type] AND (\"phase 3\"[Title/Abstract] OR \"phase III\"[Title/Abstract] OR \"multicent*\"[Title/Abstract] OR \"placebo\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 17, "ids": [ "42810372", "42804311", "42778252", "42760675", "42760593", "42733221", "42679472", "42674573", "42628475", "42624811", "42480396", "42373005", "42367170", "42331134", "42314382", "42203123", "41461068" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "hand_oa": { "query": "\"hand osteoarthritis\"[tiab] AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"hand osteoarthritis\"[Title/Abstract] AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 1, "ids": [ "42888637" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "hip_oa": { "query": "(hip osteoarthritis[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"hip osteoarthritis\"[Title/Abstract] AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 2, "ids": [ "41736456", "41706544" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "patient_experience": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (qualitative[tiab] OR \"patient experience*\"[tiab] OR \"patient perspective*\"[tiab] OR \"decision aid\"[tiab] OR \"shared decision\"[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"qualitative\"[Title/Abstract] OR \"patient experience*\"[Title/Abstract] OR \"patient perspective*\"[Title/Abstract] OR \"decision aid\"[Title/Abstract] OR \"shared decision\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 42, "ids": [ "42894777", "42893719", "42867010", "42856868", "42822019", "42815430", "42813099", "42798074", "42786419", "42778241", "42763547", "42754765", "42749381", "42746877", "42743836", "42743060", "42736753", "42724152", "42719543", "42709959", "42705869", "42699140", "42685385", "42684166", "42662949", "42638449", "42488329", "42430766", "42403955", "42383282", "42254336", "42190173", "42172738", "42036991", "42031145", "41997792", "41736402", "41338669", "41324480", "40970517", "42769616", "40105347" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "safety_redflags": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (\"rapidly progressive\"[tiab] OR \"septic arthritis\"[tiab] OR \"adverse event*\"[ti] OR cardiovascular[ti] OR \"subchondral insufficiency\"[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"rapidly progressive\"[Title/Abstract] OR \"septic arthritis\"[Title/Abstract] OR \"adverse event*\"[Title] OR \"cardiovascular\"[Title] OR \"subchondral insufficiency\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 16, "ids": [ "42898514", "42890957", "42885456", "42877127", "42857454", "42799511", "42798654", "42784228", "42751340", "42719366", "42688873", 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"42676072", "42675862", "42675763", "42675744", "42675719", "42675589", "42675585", "42675516", "42675509", "42675124", "42674575", "42674573", "42674572", "42674569", "42674568", "42674567", "42674311", "42674201", "42674178", "42673999", "42673584", "42671961", "42671954", "42671752", "42671717", "42671689", "42671652", "42671617", "42671508", "42671476", "42671303", "42671292", "42671177", "42671057", "42671032", "42670835", "42670832", "42670177", "42670167", "42668796", "42668732", "42668502", "42668447", "42668236", "42668065", "42667963", "42667499", "42667441", "42667212", "42666486", "42666380", "42666098", "42665979", "42665848", "42665688", "42665529", "42665355", "42665155", "42664894", "42664363", "42664348", "42664217", "42664184", "42664050", "42663913", "42663708", "42663698", "42663435", "42662949", "42662882", "42662567", "42661521", "42661291", "42661080", "42658267", "42657310", "42656980", "42656738", "42656724", "42655940", "42649566", "42647875", "42645742", "42640939", "42640723", "42638449", "42638423", "42637997", "42636930", "42636292", "42635968", "42635967", "42635966", "42635964", "42635963", "42635962", "42635411", "42633565", "42633461", "42633223", "42633208", "42633186", "42632745", "42632308", "42631664", "42631390", "42630681", "42630675", "42628879", "42628475", "42628336", "42628251", "42625662", "42625343", "42624811", "42624610", "42624454", "42624435", "42623907", "42622946", "42621400", "42620719", "42620590", "42620582", "42615942", "42615869", "42615074", "42610516", "42607404", "42606850", "42606637", "42606636", "42606104", "42605235", "42605158", "42605018", "42603483", "42603285", "42602932", "42601565", "42600745", "42600630", "42600309", "42598988", "42598629", "42598564", "42595218", "42586635", "42586485", "42585794", "42585691", "42584803", "42584487", "42584378", "42579894", "42578469", "42576130", "42574948", "42574728", "42574726", "42573179", "42572424", "42572207", "42571764", "42551219", "42568800", "42567109", "42564701", "42564586", "42563246", "42561945", "42561561", "42560660", "42560475", "42559811", "42557619", "42556611", "42556034", "42554852", "42554716", "42554227", "42554050", "42553886", "42553526", "42552809", "42549649", "42547948", "42547678", "42547152", "42545634", "42544937", "42544930", "42543499", "42541887", "42541683", "42541283", "42540530", "42540495", "42539704", "42537910", "42536325", "42536056", "42535426", "42532392", "42532340", "42532200", "42531924", "42531834", "42530800", "42526826", "42526367", "42525317", "42524752", "42521581", "42520998", "42520881", "42520688", "42520131", "42517638", "42509223", "42508758", "42508348", "42508309", "42508289", "42503545", "42502476", "42502312", "42501788", "42501787", "42501774", "42501732", "42501731", "42500893", "42499949", "42499916", "42499865", "42499851", "42498087", "42498062", "42497503", "42494809", "42493304", "42493258", "42492727", "42492441", "42492439", "42490749", "42489862", "42488329", "42487072", "42486000", "42485858", "42481329", "42481303", "42480396", "42479819", "42479349", "42478088", "42477121", "42476233", "42476070", "42474670", "42471867", "42471866", "42471540", "42470780", "42470749", "42470658", "42468167", "42467348", "42467093", "42467092", "42463065", "42461107", "42457032", "42448250", "42448219", "42447898", "42444567", "42444044", "42442456", "42442006", "42441320", "42440120", "42439400", "42438201", "42437550", "42437108", "42435867", "42435424", "42435290", "42434317", "42434316", "42433910", "42433680", "42433678", "42431063", "42431012", "42430766", "42429152", "42429052", "42425249", "42424755", "42424754", "42420572", "42419384", "42417980", "42417839", "42414747", "42414553", "42414085", "42413770", "42413718", "42413648", "42413604", "42413191", "42412371", "42411247", "42410245", "42409289", "42409274", "42407202", "42406545", "42405873", "42403955", "42401520", "42400930", "42400637", "42392546", "42392495", "42391815", "42390336", "42387158", "42386282", "42385366", "42385005", "42384978", "42384338", "42383284", "42383283", "42383282", "42381420", "42378829", "42376177", "42376176", "42375819", "42373005", "42371014", "42371012", "42369087", "42367196", "42367170", "42366407", "42365877", "42365478", "42364343", "42364313", "42363013", "42360437", "42359675", "42357866", "42350339", "42350030", "42349714", "42349541", "42348971", "42348397", "42348313", "42348175", "42342959", "42341526", "42341524", "42340093", "42336072", "42335992", "42335327", "42333683", "42333542", "42332283", "42331136", "42331135", "42331134", "42328725", "42325870", "42325869", "42325868", "42325867", "42322815", "42322814", "42322098", "42321007", "42320236", "42316895", "42315740", "42315086", "42314382", "42314238", "42313046", "42309785", "42309399", "42309221", "42308699", "42308385", "42307519", "42307518", "42307516", "42304597", "42303879", "42303008", "42302891", "42302831", "42302579", "42302358", "42302108", "42299823", "42297439", "42297245", "42297033", "42296689", "42295678", "42291509", "42290682", "42288187", "42285660", "42285653", "42285473", "42285326", "42285265", "42285256", "42284853", "42284708", "42284507", "42283064", "42276163", "42276136", "42275919", "42275756", "42275755", "42274962", "42274387", "42270220", "42269982", "42269953", "42269238", "42269236", "42264338", "42264324", "42263541", "42259405", "42254339", "42254338", "42254337", "42254336", "42254335", "42253755", "42250738", "42250472", "42250471", "42250470", "42250468", "42250287", "42247863", "42247862", "42247861", "42246901", "42241894", "42241892", "42239506", "42235810", "42235618", "42230177", "42229848", "42229784", "42229783", "42225263", "42224645", "42220642", "42220332", "42220331", "42220330", "42218983", "42215375", "42214882", "42214839", "42214709", "42214487", "42213505", "42211591", "42208324", "42208168", "42203123", "42202493", "42200304", "42190335", "42190173", "42189913", "42187077", "42176879", "42173234", "42173203", "42173077", "42173075", "42172889", "42172738", "42171691", "42167458", "42166916", "42162842", "42162659", "42161580", "42160831", "42156263", "42150314", "42150313", "42150308", "42142553", "42142469", "42142099", "42140793", "42140645", "42139847", "42138236", "42138151", "42134639", "42134628", "42133986", "42133198", "42132446", "42131950", "42128290", "42128266", "42128199", "42128154", "42127464", "42120779", "42119802", "42112587", "42110225", "42107742", "42107740", "42107739", "42107588", "42106296", "42106086", "42106084", "42106052", "42101649", "42101047", "42097446", "42095605", "42092467", "42087024", "42085352", "42081959", "42069776", "42069017", "42069010", "42069002", "42067631", "42058628", "42055225", "42055224", "42055222", "42055210", "42054956", "42053370", "42053079", "42036991", "42036090", "42036088", "42036086", "42036082", "42036081", "42036080", "42034184", "42034071", "42031646", "42031145", "42030858", "42025941", "42025857", "42025209", "42025190", "42023430", "42012756", "42011064", "42010641", "42009581", "42002253", "42001911", "42001905", "42000967", "42000121", "41999794", "41998410", "41997792", "41996683", "41991116", "41985700", "41985400", "41974497", "41972844", "41967985", "41967629", "41966497", "41966468", "41966426", "41966418", "41960839", "41958242", "41949152", "41948908", "41947536", "41946460", "41940811", "41934738", "41934734", "41934270", "41932675", "41930654", "41921681", "41921008", "41913050", "41911682", "41909976", "41906343", "41905756", "41903668", "41903266", "41903030", "41880818", "41878989", "41876969", "41875853", "41862305", "41862150", "41862142", "41862128", "41861146", "41855068", "41854271", "41850939", "41846285", "41833786", "41831770", "41830395", "41820084", "41808616", "41802622", "41802212", "41786669", "41786667", "41786021", "41778462", "41776952", "41766209", "41766056", "41761759", "41760441", "41760101", "41747358", "41742784", "41742778", "41741909", "41736456", "41736446", "41736402", "41728943", "41723580", "41712303", "41706544", "41693614", "41688056", "41685951", "41685775", "41681081", "41678186", "41678149", "41654305", "41651062", "41642298", "41641971", "41630443", "41617186", "41611104", "41603850", "41588166", "41577306", "41577304", "41570869", "41568519", "41566837", "41564952", "41564951", "41564285", "41552932", "41544893", "41534615", "41534613", "41534612", "41524479", "41519492", "41519491", "41514058", "41506405", "41505342", "41496305", "41485575", "41468956", "41461068", "41455026", "41431980", "41423024", "41421703", "41410145", "41405539", "41405155", "41400060", "41386507", "41368716", "41360161", "41353725", "41353720", "41338878", "41338669", "41324480", "41319842", "41318038", "41314404", "41232521", "41199106", "41108534", "41092197", "41049827", "41015915", "40972810", "40970517", "40970333", "40905642", "40885662", "40843037", "40785121", "40781794", "40770847", "40757956", "40726366", "40701349", "42769616", "40664401", "40616420", "40605688", "40590316", "40553578", "40542702", "40521922", "40495490", "40485220", "40436638", "40433805", "40401530", "40289954", "40289921", "40186495", "40156368", "40138492", "40138459", "40119526", "40105347", "39981646", "39810328", "39633532", "39611391", "39567862", "39567501", "39491540", "39469810", "39291443", "39235338", "39095949" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "OQ-1 phenotype-selected treatment": { "query": "osteoarthritis[tiab] AND (phenotyp*[ti] OR endotyp*[ti] OR stratif*[ti]) AND (randomized controlled trial[pt] OR trial[ti]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"phenotyp*\"[Title] OR \"endotyp*\"[Title] OR \"stratif*\"[Title]) AND (\"randomized controlled trial\"[Publication Type] OR \"trial\"[Title]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "OQ-2 weight loss structure": { "query": "osteoarthritis[tiab] AND (\"weight loss\"[tiab] OR semaglutide[tiab] OR tirzepatide[tiab] OR retatrutide[tiab]) AND (MRI[tiab] OR cartilage[tiab] OR structur*[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"weight loss\"[Title/Abstract] OR \"semaglutide\"[Title/Abstract] OR \"tirzepatide\"[Title/Abstract] OR \"retatrutide\"[Title/Abstract]) AND (\"MRI\"[Title/Abstract] OR \"cartilage\"[Title/Abstract] OR \"structur*\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 9, "ids": [ "42890326", "42875481", "42841007", "42767324", "42754765", "42747716", "42743836", "42692567", "42606850" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "OQ-3 exercise dose": { "query": "osteoarthritis[tiab] AND exercise[tiab] AND (dose[tiab] OR intensity[tiab] OR volume[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND \"exercise\"[Title/Abstract] AND (\"dose\"[Title/Abstract] OR \"intensity\"[Title/Abstract] OR \"volume\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 6, "ids": [ "42810372", "42775508", "42714169", "42709245", "42676087", "41802622" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "OQ-4 PRP vs placebo": { "query": "osteoarthritis[tiab] AND (\"platelet-rich plasma\"[tiab] OR PRP[tiab]) AND (placebo[tiab] OR saline[tiab]) AND randomized controlled trial[pt] AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"platelet-rich plasma\"[Title/Abstract] OR \"PRP\"[Title/Abstract]) AND (\"placebo\"[Title/Abstract] OR \"saline\"[Title/Abstract]) AND \"randomized controlled trial\"[Publication Type] AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "OQ-5 IA corticosteroid responders": { "query": "osteoarthritis[tiab] AND (corticosteroid*[tiab] OR glucocorticoid*[tiab] OR triamcinolone[tiab]) AND intra-articular[tiab] AND (randomized controlled trial[pt] OR predict*[tiab] OR responder*[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"corticosteroid*\"[Title/Abstract] OR \"glucocorticoid*\"[Title/Abstract] OR \"triamcinolone\"[Title/Abstract]) AND \"intra-articular\"[Title/Abstract] AND (\"randomized controlled trial\"[Publication Type] OR \"predict*\"[Title/Abstract] OR \"responder*\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "OQ-6 DMOAD structure+symptom": { "query": "osteoarthritis[tiab] AND (DMOAD*[tiab] OR disease-modifying[tiab] OR sprifermin[tiab] OR lorecivivint[tiab] OR LNA043[tiab]) AND (randomized controlled trial[pt] OR trial[ti] OR meta-analysis[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"dmoad*\"[Title/Abstract] OR \"disease-modifying\"[Title/Abstract] OR \"sprifermin\"[Title/Abstract] OR \"lorecivivint\"[Title/Abstract] OR \"LNA043\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"trial\"[Title] OR \"meta-analysis\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 2, "ids": [ "42760593", "42736683" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "OQ-7 NGF analgesia joint safety": { "query": "osteoarthritis[tiab] AND (tanezumab[tiab] OR fasinumab[tiab] OR \"nerve growth factor\"[tiab] OR \"rapidly progressive\"[tiab]) AND humans[mh] AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"tanezumab\"[Title/Abstract] OR \"fasinumab\"[Title/Abstract] OR \"nerve growth factor\"[Title/Abstract] OR \"rapidly progressive\"[Title/Abstract]) AND \"humans\"[MeSH Terms] AND 2026/08/28:2026/10/22[Date - Publication]", "count": 2, "ids": [ "42883797", "42750991" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "OQ-8 arthroplasty timing": { "query": "osteoarthritis[tiab] AND (arthroplasty[tiab] OR replacement[tiab]) AND (timing[tiab] OR delay*[tiab] OR \"waiting list\"[tiab] OR \"wait time\"[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"arthroplasty\"[Title/Abstract] OR \"replacement\"[Title/Abstract]) AND (\"timing\"[Title/Abstract] OR \"delay*\"[Title/Abstract] OR \"waiting list\"[Title/Abstract] OR \"wait time\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 32, "ids": [ "42895623", "42885456", "42879167", "42877794", "42863136", "42856518", "42851880", "42841833", "42841007", "42825736", "42824906", "42809099", "42785469", "42769010", "42753248", "42746655", "42710155", "42704878", "42692278", "42679856", "42541283", "42539704", "42488329", "42357866", "42315086", "42189913", "42150308", "42055222", "41997792", "41776952", "41760101", "40757956" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "OQ-9 preop sensitization": { "query": "osteoarthritis[tiab] AND (arthroplasty[tiab]) AND (sensitization[tiab] OR sensitisation[tiab] OR \"persistent postsurgical pain\"[tiab] OR \"chronic postsurgical pain\"[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND \"arthroplasty\"[Title/Abstract] AND (\"sensitization\"[Title/Abstract] OR \"sensitisation\"[Title/Abstract] OR \"persistent postsurgical pain\"[Title/Abstract] OR \"chronic postsurgical pain\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 5, "ids": [ "42883797", "42805262", "42698683", "42667441", "42467092" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "OQ-10 medicine sequence": { "query": "osteoarthritis[tiab] AND (NSAID*[tiab] OR duloxetine[tiab] OR opioid*[tiab] OR acetaminophen[tiab] OR paracetamol[tiab]) AND (\"network meta-analysis\"[tiab] OR sequenc*[tiab] OR comparative[ti]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"nsaid*\"[Title/Abstract] OR \"duloxetine\"[Title/Abstract] OR \"opioid*\"[Title/Abstract] OR \"acetaminophen\"[Title/Abstract] OR \"paracetamol\"[Title/Abstract]) AND (\"network meta-analysis\"[Title/Abstract] OR \"sequenc*\"[Title/Abstract] OR \"comparative\"[Title]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "OQ-11 contextual placebo effects": { "query": "osteoarthritis[tiab] AND (placebo[ti] OR contextual[tiab] OR \"placebo response\"[tiab] OR nocebo[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"placebo\"[Title] OR \"contextual\"[Title/Abstract] OR \"placebo response\"[Title/Abstract] OR \"nocebo\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 22, "ids": [ "42883797", "42880894", "42857855", "42856868", "42835324", "42821566", "42810372", "42804311", "42790728", "42785366", "42775215", "42760675", "42760593", "42741032", "42733221", "42728517", "42679472", "42657310", "42640939", "42606636", "42331134", "41461068" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "OQ-12 guideline absolute benefit": { "query": "osteoarthritis[tiab] AND (guideline*[ti] OR recommendation*[ti]) AND (\"absolute\"[tiab] OR threshold*[tiab] OR \"minimal important\"[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"guideline*\"[Title] OR \"recommendation*\"[Title]) AND (\"absolute\"[Title/Abstract] OR \"threshold*\"[Title/Abstract] OR \"minimal important\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "all_entry_dates": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND 2026/08/28:2026/10/22[edat]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND 2026/08/28:2026/10/22[Date - Entry]", "count": 1418, "ids": [ "42902580", "42902365", "42902285", "42902180", "42902089", "42902056", "42902054", "42901990", "42901763", "42901450", "42901240", "42900958", "42900831", "42900674", "42900514", "42900442", "42900265", "42899379", "42899283", "42899179", "42899004", "42899002", "42898949", "42898890", "42898858", "42898765", "42898719", "42898712", "42898659", "42898573", "42898514", "42898488", "42898160", "42898139", "42898098", "42897680", "42897581", "42897580", 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"42681466", "42680660", "42679988", "42679856", "42679564", "42679542", "42679529", "42679472", "42679216", "42679215", "42679075", "42678619", "42678533", "42678428", "42678427", "42677991", "42677912", "42677797", "42677741", "42677337", "42677196", "42677189", "42676898", "42676841", "42676748", "42676739", "42676700", "42676605", "42676528", "42676322", "42676087", "42676072", "42675862", "42675763", "42675744", "42675719", "42675589", "42675585", "42675516", "42675509", "42675124", "42674575", "42674573", "42674572", "42674569", "42674568", "42674567", "42674311", "42674201", "42674178", "42673999", "42673584", "42671961", "42671954", "42671752", "42671717", "42671689", "42671652", "42671617", "42671508", "42671476", "42671303", "42671292", "42671177", "42671057", "42671032", "42670835", "42670832", "42670568", "42670507", "42670177", "42670167", "42670071", "42668919", "42668877", "42668833", "42668796", "42668791", "42668732", "42668582", "42668502", "42668460", "42668447", "42668236", "42668065", "42667963", "42667499", "42667441", "42667212", "42667090", "42666486", "42666380", "42666219", "42666203", "42666098", "42665979", "42665848", "42665688", "42665529", "42665355", "42665155", "42664894", "42664712", "42664363", "42664348", "42664217", "42664184", "42664050", "42663913", "42663708", "42663698", "42663495", "42663435", "42662965", "42662949", "42662882", "42662567", "42662246", "42662201", "42662126", "42662120", "42662097", "42661521", "42661339", "42661329", "42661291", "42661187", "42661147", "42661080", "42660697", "42660422", "42660311", "42660307", "42660161", "42659892" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "OQ-23 methotrexate inflammation": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (methotrexate OR PROMOTE OR hs-CRP) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"methotrexate\"[Supplementary Concept] OR \"methotrexate\"[All Fields] OR \"methotrexate\"[MeSH Terms] OR \"methotrexate s\"[All Fields] OR \"methotrexates\"[All Fields] OR (\"promote\"[All Fields] OR \"promoted\"[All Fields] OR \"promotes\"[All Fields] OR \"promoting\"[All Fields] OR \"promotion\"[All Fields] OR \"promotional\"[All Fields] OR \"promotions\"[All Fields] OR \"promotive\"[All Fields]) OR (\"c reactive protein\"[Supplementary Concept] OR \"c reactive protein\"[All Fields] OR \"hs crp\"[All Fields] OR \"c reactive protein\"[MeSH Terms] OR (\"c reactive\"[All Fields] AND \"protein\"[All Fields]) OR (\"hs\"[All Fields] AND \"crp\"[All Fields]))) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 218, "ids": [ "42899179", "42898765", "42898573", "42897005", "42892544", "42891689", "42890620", "42889631", "42889536", "42889420", "42888265", "42885467", "42885301", "42884179", "42881938", "42880692", "42878435", "42878073", "42877102", "42876417", "42876321", "42875770", "42871373", "42871292", "42869812", "42864497", "42863821", "42863533", "42863186", "42861094", "42860389", "42859207", "42858303", "42858199", "42857734", "42854762", "42853928", "42853095", "42852532", "42851919", "42851625", "42851535", "42851053", "42844706", "42839279", "42838977", "42837321", "42835543", "42834867", "42833978", "42829238", "42828803", "42826603", "42825366", "42824338", "42821663", "42820961", "42820640", "42819405", "42817159", "42815820", "42814176", "42812934", "42812603", "42811796", "42811430", "42805962", "42801095", "42799511", "42798389", "42798045", "42794637", "42794410", "42793042", "42790148", "42787146", "42785223", "42783637", "42778761", "42778437", "42775788", "42773801", "42772285", "42769705", "42769654", "42769154", "42766144", "42762332", "42761531", "42761148", "42760675", "42757457", "42756916", "42755648", "42755447", "42750882", "42750457", "42750165", "42749046", "42747250", "42743824", "42742542", "42742047", "42741686", "42738788", "42737766", "42736683", "42734879", "42733678", "42733560", "42733189", "42730104", "42729817", "42729156", "42726129", "42722025", "42717782", "42716267", "42714638", "42713426", "42710155", "42709376", "42708084", "42698890", "42698020", "42696704", "42696062", "42692232", "42684455", "42682739", "42679542", "42678619", "42675719", "42674201", "42674178", "42667212", "42666380", "42665979", "42664348", "42664050", "42663435", "42662567", "42632745", "42632308", "42628251", "42624454", "42624435", "42606637", "42601565", "42586485", "42571764", "42551219", "42563246", "42556034", "42545634", "42532392", "42531834", "42530800", "42517638", "42508309", "42499865", "42498087", "42492727", "42490749", "42480396", "42476233", "42476070", "42471867", "42471866", "42471540", "42463065", "42439400", "42431012", "42429052", "42413718", "42413648", "42410245", "42405873", "42401520", "42400930", "42391815", "42364313", "42349714", "42325870", "42285660", "42285653", "42284507", "42276163", "42270220", "42269236", "42253755", "42250738", "42241894", "42229784", "42189913", "42176879", "42162842", "42142553", "42131950", "42128266", "42058628", "41985400", "41934738", "41921008", "41913050", "41909976", "41761759", "41760101", "41685775", "41641971", "41519491", "41485575", "41386507", "41353720", "40553578", "40485220", "40433805", "39291443" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "sham_embolization": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (embolization OR embolisation) AND (sham OR randomized OR randomised) AND 2026/08/28:2026/10/22[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"embol\"[All Fields] OR \"embolics\"[All Fields] OR \"embolisation\"[All Fields] OR \"embolization, therapeutic\"[MeSH Terms] OR (\"embolization\"[All Fields] AND \"therapeutic\"[All Fields]) OR \"therapeutic embolization\"[All Fields] OR \"embolization\"[All Fields] OR \"embolisations\"[All Fields] OR \"embolise\"[All Fields] OR \"embolised\"[All Fields] OR \"embolising\"[All Fields] OR \"embolism\"[MeSH Terms] OR \"embolism\"[All Fields] OR \"embolic\"[All Fields] OR \"embolisms\"[All Fields] OR \"embolizations\"[All Fields] OR \"embolize\"[All Fields] OR \"embolized\"[All Fields] OR \"embolizes\"[All Fields] OR \"embolizing\"[All Fields] OR (\"embol\"[All Fields] OR \"embolics\"[All Fields] OR \"embolisation\"[All Fields] OR \"embolization, therapeutic\"[MeSH Terms] OR (\"embolization\"[All Fields] AND \"therapeutic\"[All Fields]) OR \"therapeutic embolization\"[All Fields] OR \"embolization\"[All Fields] OR \"embolisations\"[All Fields] OR \"embolise\"[All Fields] OR \"embolised\"[All Fields] OR \"embolising\"[All Fields] OR \"embolism\"[MeSH Terms] OR \"embolism\"[All Fields] OR \"embolic\"[All Fields] OR \"embolisms\"[All Fields] OR \"embolizations\"[All Fields] OR \"embolize\"[All Fields] OR \"embolized\"[All Fields] OR \"embolizes\"[All Fields] OR \"embolizing\"[All Fields])) AND (\"salicylhydroxamic acid\"[Supplementary Concept] OR \"salicylhydroxamic acid\"[All Fields] OR \"sham\"[All Fields] OR (\"random allocation\"[MeSH Terms] OR (\"random\"[All Fields] AND \"allocation\"[All Fields]) OR \"random allocation\"[All Fields] OR \"randomization\"[All Fields] OR \"randomized\"[All Fields] OR \"random\"[All Fields] OR \"randomisation\"[All Fields] OR \"randomisations\"[All Fields] OR \"randomise\"[All Fields] OR \"randomised\"[All Fields] OR \"randomising\"[All Fields] OR \"randomizations\"[All Fields] OR \"randomize\"[All Fields] OR \"randomizes\"[All Fields] OR \"randomizing\"[All Fields] OR \"randomness\"[All Fields] OR \"randoms\"[All Fields]) OR (\"random allocation\"[MeSH Terms] OR (\"random\"[All Fields] AND \"allocation\"[All Fields]) OR \"random allocation\"[All Fields] OR \"randomization\"[All Fields] OR \"randomized\"[All Fields] OR \"random\"[All Fields] OR \"randomisation\"[All Fields] OR \"randomisations\"[All Fields] OR \"randomise\"[All Fields] OR \"randomised\"[All Fields] OR \"randomising\"[All Fields] OR \"randomizations\"[All Fields] OR \"randomize\"[All Fields] OR \"randomizes\"[All Fields] OR \"randomizing\"[All Fields] OR \"randomness\"[All Fields] OR \"randoms\"[All Fields])) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 7, "ids": [ "42824590", "42661080", "42585691", "42576130", "42477121", "42371012", "42208168" ], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999" ] } }, "cochrane_guidelines": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND (guideline[pt] OR practice guideline[pt] OR guideline*[ti] OR recommendation*[ti] OR consensus[ti]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"guideline*\"[Title] OR \"recommendation*\"[Title] OR \"consensus\"[Title]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "cochrane_epidemiology_burden": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND (\"global burden\"[tiab] OR GBD[tiab] OR prevalence[ti] OR incidence[ti] OR burden[ti]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"global burden\"[Title/Abstract] OR \"GBD\"[Title/Abstract] OR \"prevalence\"[Title] OR \"incidence\"[Title] OR \"burden\"[Title]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "cochrane_diagnosis_classification": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND (classification criteria[tiab] OR diagnos*[ti] OR phenotyp*[ti] OR \"early osteoarthritis\"[tiab]) AND (systematic review[pt] OR meta-analysis[pt] OR validation[ti] OR cohort[ti]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"classification criteria\"[Title/Abstract] OR \"diagnos*\"[Title] OR \"phenotyp*\"[Title] OR \"early osteoarthritis\"[Title/Abstract]) AND (\"systematic review\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"validation\"[Title] OR \"cohort\"[Title]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "cochrane_biology": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND (cartilage[ti] OR chondrocyte*[ti] OR synovi*[ti] OR subchondral[ti]) AND (human[mh] OR patients[tiab]) AND (review[pt] OR \"single-cell\"[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"cartilage\"[Title] OR \"chondrocyte*\"[Title] OR \"synovi*\"[Title] OR \"subchondral\"[Title]) AND (\"humans\"[MeSH Terms] OR \"patients\"[Title/Abstract]) AND (\"review\"[Publication Type] OR \"single-cell\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "cochrane_pain_mechanisms": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND (sensitization[tiab] OR sensitisation[tiab] OR nociplastic[tiab] OR \"pain mechanism*\"[tiab] OR neuropathic[ti]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"sensitization\"[Title/Abstract] OR \"sensitisation\"[Title/Abstract] OR \"nociplastic\"[Title/Abstract] OR \"pain mechanism*\"[Title/Abstract] OR \"neuropathic\"[Title]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "cochrane_genetics_risk": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND (GWAS[tiab] OR genome-wide[tiab] OR \"mendelian randomization\"[tiab] OR polygenic[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"GWAS\"[Title/Abstract] OR \"genome-wide\"[Title/Abstract] OR \"mendelian randomization\"[Title/Abstract] OR \"polygenic\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "cochrane_exercise_weight_selfmgmt": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND (exercise[ti] OR \"weight loss\"[tiab] OR education[ti] OR self-management[tiab] OR physiotherap*[ti]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"exercise\"[Title] OR \"weight loss\"[Title/Abstract] OR \"education\"[Title] OR \"self-management\"[Title/Abstract] OR \"physiotherap*\"[Title]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "cochrane_glp1_incretin": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND (semaglutide[tiab] OR tirzepatide[tiab] OR GLP-1[tiab] OR \"glucagon-like peptide\"[tiab] OR incretin[tiab]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"semaglutide\"[Title/Abstract] OR \"tirzepatide\"[Title/Abstract] OR \"GLP-1\"[Title/Abstract] OR \"glucagon-like peptide\"[Title/Abstract] OR \"incretin\"[Title/Abstract]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "cochrane_pharmacologic": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND (NSAID*[tiab] OR \"anti-inflammatory agents, non-steroidal\"[mh] OR acetaminophen[tiab] OR paracetamol[tiab] OR duloxetine[tiab] OR opioid*[tiab] OR tramadol[tiab] OR topical[ti]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"nsaid*\"[Title/Abstract] OR \"anti inflammatory agents, non steroidal\"[MeSH Terms] OR \"acetaminophen\"[Title/Abstract] OR \"paracetamol\"[Title/Abstract] OR \"duloxetine\"[Title/Abstract] OR \"opioid*\"[Title/Abstract] OR \"tramadol\"[Title/Abstract] OR \"topical\"[Title]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "Restrictions achieved. start and count adjusted to 0, 9999", "No items found." ] } }, "cochrane_injections_orthobiologics": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND (intra-articular[tiab] OR corticosteroid*[tiab] OR triamcinolone[tiab] OR hyaluron*[tiab] OR \"platelet-rich plasma\"[tiab] OR PRP[tiab] OR \"stem cell*\"[tiab] OR mesenchymal[tiab] OR \"genicular\"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/22[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"intra-articular\"[Title/Abstract] OR \"corticosteroid*\"[Title/Abstract] OR \"triamcinolone\"[Title/Abstract] OR \"hyaluron*\"[Title/Abstract] OR \"platelet-rich plasma\"[Title/Abstract] OR \"PRP\"[Title/Abstract] OR \"stem cell*\"[Title/Abstract] OR \"mesenchymal\"[Title/Abstract] OR \"genicular\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/22[Date - Publication]", "count": 0, "ids": [], "warnings": { 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