{ "date": "2026-10-15", "condition": "osteoarthritis", "date_from": "2026-08-28", "date_to": "2026-10-15", "pubmed_eutilities": { "overall_cochrane": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 0, "ids": [] }, "overall_cochrane_edat": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND 2026/08/28:2026/10/15[edat]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND 2026/08/28:2026/10/15[Date - Entry]", "count": 0, "ids": [] }, "guidelines": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (guideline[pt] OR practice guideline[pt] OR guideline*[ti] OR recommendation*[ti] OR consensus[ti]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"guideline*\"[Title] OR \"recommendation*\"[Title] OR \"consensus\"[Title]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 18, "ids": [ "42838839", "42825586", "42825585", "42809374", "42802502", "42749319", "42701879", "42699140", "42683462", "42683154", "42645742", "42520131", "42487072", "42284853", "41742784", "41688056", "41524479", "40156368" ] }, "epidemiology_burden": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (\"global burden\"[tiab] OR GBD[tiab] OR prevalence[ti] OR incidence[ti] OR burden[ti]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"global burden\"[Title/Abstract] OR \"GBD\"[Title/Abstract] OR \"prevalence\"[Title] OR \"incidence\"[Title] OR \"burden\"[Title]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 36, "ids": [ "42868005", "42866781", "42857454", "42841006", "42839719", "42814176", "42813150", "42809099", "42808667", "42798306", "42770731", "42744301", "42743872", "42739905", "42733749", "42732557", "42724153", "42714341", "42709298", "42703347", "42701772", "42695435", "42683688", "42679988", "42676605", "42637997", "42633461", "42420572", "42348175", "42283064", "42229783", "42202493", "41862128", "41833786", "41830395", "41786667" ] }, "diagnosis_classification": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (classification criteria[tiab] OR diagnos*[ti] OR phenotyp*[ti] OR \"early osteoarthritis\"[tiab]) AND (systematic review[pt] OR meta-analysis[pt] OR validation[ti] OR cohort[ti]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"classification criteria\"[Title/Abstract] OR \"diagnos*\"[Title] OR \"phenotyp*\"[Title] OR \"early osteoarthritis\"[Title/Abstract]) AND (\"systematic review\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"validation\"[Title] OR \"cohort\"[Title]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 5, "ids": [ "42620719", "42461107", "42220330", "41455026", "41049827" ] }, "biology": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (cartilage[ti] OR chondrocyte*[ti] OR synovi*[ti] OR subchondral[ti]) AND (human[mh] OR patients[tiab]) AND (review[pt] OR \"single-cell\"[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"cartilage\"[Title] OR \"chondrocyte*\"[Title] OR \"synovi*\"[Title] OR \"subchondral\"[Title]) AND (\"humans\"[MeSH Terms] OR \"patients\"[Title/Abstract]) AND (\"review\"[Publication Type] OR \"single-cell\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 30, "ids": [ "42871533", "42862839", "42860389", "42825366", "42811796", "42810572", "42802793", "42801095", "42794637", "42791918", "42761519", "42757661", "42757457", "42750991", "42743060", "42740997", "42729817", "42725850", "42692563", "42679564", "42636292", "42598988", "42492727", "42474670", "42431012", "42218983", "42189913", "42128266", "41921008", "39291443" ] }, "pain_mechanisms": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (sensitization[tiab] OR sensitisation[tiab] OR nociplastic[tiab] OR \"pain mechanism*\"[tiab] OR neuropathic[ti]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"sensitization\"[Title/Abstract] OR \"sensitisation\"[Title/Abstract] OR \"nociplastic\"[Title/Abstract] OR \"pain mechanism*\"[Title/Abstract] OR \"neuropathic\"[Title]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 31, "ids": [ "42857293", "42857188", "42853345", "42840734", "42828189", "42820961", "42782280", "42770731", "42769256", "42766569", "42761406", "42759264", "42755904", "42750991", "42750572", "42739852", "42736980", "42733314", "42714824", "42709140", "42707081", "42668447", "42667441", "42645742", "42635964", "42606637", "42531924", "42467092", "42387158", "42383284", "42349541" ] }, "genetics_risk": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (GWAS[tiab] OR genome-wide[tiab] OR \"mendelian randomization\"[tiab] OR polygenic[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"GWAS\"[Title/Abstract] OR \"genome-wide\"[Title/Abstract] OR \"mendelian randomization\"[Title/Abstract] OR \"polygenic\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 23, "ids": [ "42861094", "42855042", "42794810", "42792836", "42772042", "42770026", "42762435", "42759090", "42722059", "42687813", "42675719", "42671689", "42671508", "42662567", "42656980", "42606104", "42520998", "42375819", "42322815", "42285256", "42269982", "42110225", "41972844" ] }, "exercise_weight_selfmgmt": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (exercise[ti] OR \"weight loss\"[tiab] OR education[ti] OR self-management[tiab] OR physiotherap*[ti]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"exercise\"[Title] OR \"weight loss\"[Title/Abstract] OR \"education\"[Title] OR \"self-management\"[Title/Abstract] OR \"physiotherap*\"[Title]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 20, "ids": [ "42775508", "42772870", "42730869", "42715249", "42714961", "42703695", "42676087", "42628475", "42623907", "42579894", "42407202", "42373005", "42366407", "42241894", "41802622", "41742784", "41736456", "41723580", "41706544", "41505342" ] }, "glp1_incretin": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (semaglutide[tiab] OR tirzepatide[tiab] OR GLP-1[tiab] OR \"glucagon-like peptide\"[tiab] OR incretin[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"semaglutide\"[Title/Abstract] OR \"tirzepatide\"[Title/Abstract] OR \"GLP-1\"[Title/Abstract] OR \"glucagon-like peptide\"[Title/Abstract] OR \"incretin\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 21, "ids": [ "42856009", "42827061", "42814954", "42810372", "42778434", "42772870", "42767324", "42754765", "42747716", "42730869", "42706128", "42692567", "42479349", "42463065", "42448219", "42412371", "42348175", "42321007", "42274387", "42225263", "42107588" ] }, "pharmacologic": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (NSAID*[tiab] OR \"anti-inflammatory agents, non-steroidal\"[mh] OR acetaminophen[tiab] OR paracetamol[tiab] OR duloxetine[tiab] OR opioid*[tiab] OR tramadol[tiab] OR topical[ti]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"nsaid*\"[Title/Abstract] OR \"anti inflammatory agents, non steroidal\"[MeSH Terms] OR \"acetaminophen\"[Title/Abstract] OR \"paracetamol\"[Title/Abstract] OR \"duloxetine\"[Title/Abstract] OR \"opioid*\"[Title/Abstract] OR \"tramadol\"[Title/Abstract] OR \"topical\"[Title]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 8, "ids": [ "42733221", "42730321", "42714961", "42679472", "42674575", "42544937", "42036080", "41461068" ] }, "injections_orthobiologics": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (intra-articular[tiab] OR corticosteroid*[tiab] OR triamcinolone[tiab] OR hyaluron*[tiab] OR \"platelet-rich plasma\"[tiab] OR PRP[tiab] OR \"stem cell*\"[tiab] OR mesenchymal[tiab] OR \"genicular\"[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"intra-articular\"[Title/Abstract] OR \"corticosteroid*\"[Title/Abstract] OR \"triamcinolone\"[Title/Abstract] OR \"hyaluron*\"[Title/Abstract] OR \"platelet-rich plasma\"[Title/Abstract] OR \"PRP\"[Title/Abstract] OR \"stem cell*\"[Title/Abstract] OR \"mesenchymal\"[Title/Abstract] OR \"genicular\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 18, "ids": [ "42804311", "42671292", "42585691", "42524752", "42424755", "42371012", "42303879", "42302358", "42214487", "42208168", "42101047", "42055224", "42036080", "41766056", "41760441", "41685775", "41514058", "41496305" ] }, "surgery_arthroplasty": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (arthroplasty[tiab] OR replacement[ti] OR osteotomy[tiab] OR arthroscop*[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"arthroplasty\"[Title/Abstract] OR \"replacement\"[Title] OR \"osteotomy\"[Title/Abstract] OR \"arthroscop*\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 31, "ids": [ "42804311", "42803050", "42789133", "42786446", "42778252", "42775510", "42770474", "42770473", "42730321", "42721566", "42714169", "42674575", "42624811", "42526367", "42360437", "42235618", "42203123", "42106084", "42055224", "42055222", "42036090", "42036086", "42036080", "42025190", "42002253", "41966468", "41934738", "41862142", "41862128", "41786669", "41461068" ] }, "dmoad": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (disease-modifying[tiab] OR DMOAD*[tiab] OR sprifermin[tiab] OR lorecivivint[tiab] OR tanezumab[tiab] OR \"anti-NGF\"[tiab] OR \"nerve growth factor\"[tiab] OR ADAMTS*[tiab] OR \"structure modif*\"[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"disease-modifying\"[Title/Abstract] OR \"dmoad*\"[Title/Abstract] OR \"sprifermin\"[Title/Abstract] OR \"lorecivivint\"[Title/Abstract] OR \"tanezumab\"[Title/Abstract] OR \"anti-NGF\"[Title/Abstract] OR \"nerve growth factor\"[Title/Abstract] OR \"adamts*\"[Title/Abstract] OR \"structure modif*\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 116, "ids": [ "42872559", "42871198", "42866276", "42863418", "42860389", "42859083", "42858199", "42856009", "42855042", "42852532", "42851919", "42851900", "42851840", "42850492", "42849669", "42849031", "42844420", "42840734", "42838868", "42835324", "42828821", "42828757", "42828279", "42826836", "42815820", "42814102", "42808736", "42803147", "42800293", "42798654", "42792871", "42792836", "42792765", "42791579", "42790833", "42789011", "42784800", "42779961", "42778434", "42767324", "42766346", "42761062", "42760593", "42756019", "42755648", "42753488", "42752667", "42750991", "42750882", "42750165", "42747754", "42747683", "42742542", "42741701", "42741686", "42741326", "42737766", "42736683", "42736608", "42734458", "42733614", "42733560", "42733189", "42731244", "42729156", "42727834", "42725850", "42725019", "42722058", "42716128", "42714824", "42714638", "42711652", "42706131", "42700728", "42695436", "42695425", "42692566", "42692565", "42692564", "42692563", "42686975", "42685748", "42679542", "42677991", "42675744", "42674568", "42673999", "42635964", "42633565", "42632308", "42621400", "42602932", "42601565", "42584803", "42573179", "42564586", "42554227", "42479819", "42471867", "42468167", "42435424", "42431012", "42410245", "42400930", "42391815", "42381420", "42322814", "42297245", "42284507", "42269982", "42176879", "42138236", "41386507", "40553578", "39291443" ] }, "biomarkers_imaging": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (biomarker*[ti] OR MRI[ti] OR \"magnetic resonance\"[ti] OR radiograph*[ti] OR \"artificial intelligence\"[tiab] OR \"deep learning\"[tiab]) AND (cohort[tiab] OR validation[tiab] OR systematic review[pt]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"biomarker*\"[Title] OR \"MRI\"[Title] OR \"magnetic resonance\"[Title] OR \"radiograph*\"[Title] OR \"artificial intelligence\"[Title/Abstract] OR \"deep learning\"[Title/Abstract]) AND (\"cohort\"[Title/Abstract] OR \"validation\"[Title/Abstract] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 62, "ids": [ "42870426", "42870156", "42858765", "42851913", "42851900", "42845196", "42833978", "42833930", "42830692", "42817870", "42817401", "42815430", "42812297", "42802793", "42792832", "42786113", "42782519", "42781773", "42768777", "42763426", "42762162", "42761148", "42759284", "42757717", "42741032", "42739905", "42736660", "42731810", "42726790", "42726694", "42718991", "42709577", "42684455", "42680660", "42678533", "42677189", "42675516", "42675124", "42674311", "42667212", "42664217", "42661521", "42628251", "42622946", "42615942", "42605235", "42605018", "42584803", "42479819", "42467093", "42461107", "42376176", "42331136", "42264324", "42259405", "42247863", "42173234", "42092467", "42069776", "41991116", "41049827", "40757956" ] }, "trials_phase3": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (randomized controlled trial[pt]) AND (\"phase 3\"[tiab] OR \"phase III\"[tiab] OR multicent*[tiab] OR placebo[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND \"randomized controlled trial\"[Publication Type] AND (\"phase 3\"[Title/Abstract] OR \"phase III\"[Title/Abstract] OR \"multicent*\"[Title/Abstract] OR \"placebo\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 17, "ids": [ "42810372", "42804311", "42778252", "42760675", "42760593", "42733221", "42679472", "42674573", "42628475", "42624811", "42480396", "42373005", "42367170", "42331134", "42314382", "42203123", "41461068" ] }, "hand_oa": { "query": "\"hand osteoarthritis\"[tiab] AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"hand osteoarthritis\"[Title/Abstract] AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 0, "ids": [] }, "hip_oa": { "query": "(hip osteoarthritis[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"hip osteoarthritis\"[Title/Abstract] AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 2, "ids": [ "41736456", "41706544" ] }, "patient_experience": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (qualitative[tiab] OR \"patient experience*\"[tiab] OR \"patient perspective*\"[tiab] OR \"decision aid\"[tiab] OR \"shared decision\"[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"qualitative\"[Title/Abstract] OR \"patient experience*\"[Title/Abstract] OR \"patient perspective*\"[Title/Abstract] OR \"decision aid\"[Title/Abstract] OR \"shared decision\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 38, "ids": [ "42867010", "42856868", "42822019", "42815430", "42813099", "42798074", "42786419", "42778241", "42763547", "42754765", "42749381", "42746877", "42743836", "42743060", "42736753", "42724152", "42719543", "42709959", "42705869", "42699140", "42685385", "42684166", "42638449", "42488329", "42430766", "42403955", "42383282", "42254336", "42190173", "42172738", "42036991", "42031145", "41997792", "41736402", "41324480", "40970517", "42769616", "40105347" ] }, "safety_redflags": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (\"rapidly progressive\"[tiab] OR \"septic arthritis\"[tiab] OR \"adverse event*\"[ti] OR cardiovascular[ti] OR \"subchondral insufficiency\"[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"rapidly progressive\"[Title/Abstract] OR \"septic arthritis\"[Title/Abstract] OR \"adverse event*\"[Title] OR \"cardiovascular\"[Title] OR \"subchondral insufficiency\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 12, "ids": [ "42857454", "42799511", "42798654", "42784228", "42751340", "42719366", "42688873", "42547678", "42470749", "42101047", "41947536", "41421703" ] }, "all_rct": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND randomized controlled trial[pt] AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND \"randomized controlled trial\"[Publication Type] AND 2026/08/28:2026/10/15[Date - Publication]", "count": 61, "ids": [ "42810372", "42804311", "42803050", "42790346", "42786446", "42778252", "42775508", "42770474", "42770473", "42760675", "42760593", "42744628", "42733221", "42730321", "42715249", "42714961", "42709245", "42703695", "42679472", "42674575", "42674573", "42671292", "42640939", "42628475", "42624811", "42585691", "42574728", "42544937", "42526367", "42492439", "42480396", "42444044", "42442456", "42424755", "42413648", "42373005", "42371012", "42367170", "42360437", "42331134", "42314382", "42235618", "42203123", "42140793", "42106084", "42095605", "42055224", "42055222", "42036090", "42036086", "42036080", "42025190", "42002253", "41934738", "41736456", "41723580", "41706544", "41693614", "41505342", "41461068", "40757956" ] }, "all_ma": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND (meta-analysis[pt] OR systematic review[pt]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND (\"meta-analysis\"[Publication Type] OR \"systematic review\"[Publication Type]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 59, "ids": [ "42852623", "42824162", "42789133", "42780316", "42775510", "42772870", "42761148", "42730869", "42721566", "42714169", "42706850", "42676087", "42649566", "42636292", "42623907", "42598988", "42598564", "42586635", "42579894", "42549649", "42524752", "42501788", "42501732", "42478088", "42461107", "42407202", "42371014", "42366407", "42342959", "42335327", "42303879", "42302358", "42284708", "42241894", "42214882", "42214487", "42208168", "42190173", "42101047", "42069776", "42034071", "42025941", "41966468", "41876969", "41862142", "41862128", "41833786", "41802622", "41786669", "41766056", "41760441", "41742784", "41685775", "41577304", "41519491", "41514058", "41496305", "41455026", "41324480" ] }, "all": { "query": "(osteoarthritis[tiab] OR osteoarthritis[mh]) AND 2026/08/28:2026/10/15[dp]", "translation": "(\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 1779, "ids": [], "ids_note": "count only; IDs not stored (1,779 records); triage used the topic queries" } }, "pubmed_tier1_open_question_searches": { "OQ-1 phenotype-selected treatment": { "query": "osteoarthritis[tiab] AND (phenotyp*[ti] OR endotyp*[ti] OR stratif*[ti]) AND (randomized controlled trial[pt] OR trial[ti]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"phenotyp*\"[Title] OR \"endotyp*\"[Title] OR \"stratif*\"[Title]) AND (\"randomized controlled trial\"[Publication Type] OR \"trial\"[Title]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 0, "ids": [] }, "OQ-2 weight loss structure": { "query": "osteoarthritis[tiab] AND (\"weight loss\"[tiab] OR semaglutide[tiab] OR tirzepatide[tiab] OR retatrutide[tiab]) AND (MRI[tiab] OR cartilage[tiab] OR structur*[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"weight loss\"[Title/Abstract] OR \"semaglutide\"[Title/Abstract] OR \"tirzepatide\"[Title/Abstract] OR \"retatrutide\"[Title/Abstract]) AND (\"MRI\"[Title/Abstract] OR \"cartilage\"[Title/Abstract] OR \"structur*\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 7, "ids": [ "42841007", "42767324", "42754765", "42747716", "42743836", "42692567", "42606850" ] }, "OQ-3 exercise dose": { "query": "osteoarthritis[tiab] AND exercise[tiab] AND (dose[tiab] OR intensity[tiab] OR volume[tiab]) AND (randomized controlled trial[pt] OR meta-analysis[pt]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND \"exercise\"[Title/Abstract] AND (\"dose\"[Title/Abstract] OR \"intensity\"[Title/Abstract] OR \"volume\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"meta-analysis\"[Publication Type]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 6, "ids": [ "42810372", "42775508", "42714169", "42709245", "42676087", "41802622" ] }, "OQ-4 PRP vs placebo": { "query": "osteoarthritis[tiab] AND (\"platelet-rich plasma\"[tiab] OR PRP[tiab]) AND (placebo[tiab] OR saline[tiab]) AND randomized controlled trial[pt] AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"platelet-rich plasma\"[Title/Abstract] OR \"PRP\"[Title/Abstract]) AND (\"placebo\"[Title/Abstract] OR \"saline\"[Title/Abstract]) AND \"randomized controlled trial\"[Publication Type] AND 2026/08/28:2026/10/15[Date - Publication]", "count": 0, "ids": [] }, "OQ-5 IA corticosteroid responders": { "query": "osteoarthritis[tiab] AND (corticosteroid*[tiab] OR glucocorticoid*[tiab] OR triamcinolone[tiab]) AND intra-articular[tiab] AND (randomized controlled trial[pt] OR predict*[tiab] OR responder*[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"corticosteroid*\"[Title/Abstract] OR \"glucocorticoid*\"[Title/Abstract] OR \"triamcinolone\"[Title/Abstract]) AND \"intra-articular\"[Title/Abstract] AND (\"randomized controlled trial\"[Publication Type] OR \"predict*\"[Title/Abstract] OR \"responder*\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 0, "ids": [] }, "OQ-6 DMOAD structure+symptom": { "query": "osteoarthritis[tiab] AND (DMOAD*[tiab] OR disease-modifying[tiab] OR sprifermin[tiab] OR lorecivivint[tiab] OR LNA043[tiab]) AND (randomized controlled trial[pt] OR trial[ti] OR meta-analysis[pt]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"dmoad*\"[Title/Abstract] OR \"disease-modifying\"[Title/Abstract] OR \"sprifermin\"[Title/Abstract] OR \"lorecivivint\"[Title/Abstract] OR \"LNA043\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"trial\"[Title] OR \"meta-analysis\"[Publication Type]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 2, "ids": [ "42760593", "42736683" ] }, "OQ-7 NGF analgesia joint safety": { "query": "osteoarthritis[tiab] AND (tanezumab[tiab] OR fasinumab[tiab] OR \"nerve growth factor\"[tiab] OR \"rapidly progressive\"[tiab]) AND humans[mh] AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"tanezumab\"[Title/Abstract] OR \"fasinumab\"[Title/Abstract] OR \"nerve growth factor\"[Title/Abstract] OR \"rapidly progressive\"[Title/Abstract]) AND \"humans\"[MeSH Terms] AND 2026/08/28:2026/10/15[Date - Publication]", "count": 1, "ids": [ "42750991" ] }, "OQ-8 arthroplasty timing": { "query": "osteoarthritis[tiab] AND (arthroplasty[tiab] OR replacement[tiab]) AND (timing[tiab] OR delay*[tiab] OR \"waiting list\"[tiab] OR \"wait time\"[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"arthroplasty\"[Title/Abstract] OR \"replacement\"[Title/Abstract]) AND (\"timing\"[Title/Abstract] OR \"delay*\"[Title/Abstract] OR \"waiting list\"[Title/Abstract] OR \"wait time\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 28, "ids": [ "42863136", "42856518", "42851880", "42841833", "42841007", "42825736", "42824906", "42809099", "42785469", "42769010", "42753248", "42746655", "42710155", "42704878", "42692278", "42679856", "42541283", "42539704", "42488329", "42357866", "42315086", "42189913", "42150308", "42055222", "41997792", "41776952", "41760101", "40757956" ] }, "OQ-9 preop sensitization": { "query": "osteoarthritis[tiab] AND (arthroplasty[tiab]) AND (sensitization[tiab] OR sensitisation[tiab] OR \"persistent postsurgical pain\"[tiab] OR \"chronic postsurgical pain\"[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND \"arthroplasty\"[Title/Abstract] AND (\"sensitization\"[Title/Abstract] OR \"sensitisation\"[Title/Abstract] OR \"persistent postsurgical pain\"[Title/Abstract] OR \"chronic postsurgical pain\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 4, "ids": [ "42805262", "42698683", "42667441", "42467092" ] }, "OQ-10 medicine sequence": { "query": "osteoarthritis[tiab] AND (NSAID*[tiab] OR duloxetine[tiab] OR opioid*[tiab] OR acetaminophen[tiab] OR paracetamol[tiab]) AND (\"network meta-analysis\"[tiab] OR sequenc*[tiab] OR comparative[ti]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"nsaid*\"[Title/Abstract] OR \"duloxetine\"[Title/Abstract] OR \"opioid*\"[Title/Abstract] OR \"acetaminophen\"[Title/Abstract] OR \"paracetamol\"[Title/Abstract]) AND (\"network meta-analysis\"[Title/Abstract] OR \"sequenc*\"[Title/Abstract] OR \"comparative\"[Title]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 0, "ids": [] }, "OQ-11 contextual placebo effects": { "query": "osteoarthritis[tiab] AND (placebo[ti] OR contextual[tiab] OR \"placebo response\"[tiab] OR nocebo[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"placebo\"[Title] OR \"contextual\"[Title/Abstract] OR \"placebo response\"[Title/Abstract] OR \"nocebo\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 20, "ids": [ "42857855", "42856868", "42835324", "42821566", "42810372", "42804311", "42790728", "42785366", "42775215", "42760675", "42760593", "42741032", "42733221", "42728517", "42679472", "42657310", "42640939", "42606636", "42331134", "41461068" ] }, "OQ-12 guideline absolute benefit": { "query": "osteoarthritis[tiab] AND (guideline*[ti] OR recommendation*[ti]) AND (\"absolute\"[tiab] OR threshold*[tiab] OR \"minimal important\"[tiab]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"osteoarthritis\"[Title/Abstract] AND (\"guideline*\"[Title] OR \"recommendation*\"[Title]) AND (\"absolute\"[Title/Abstract] OR \"threshold*\"[Title/Abstract] OR \"minimal important\"[Title/Abstract]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 0, "ids": [] } }, "pubmed_targeted": { "promote_methotrexate": "methotrexate[tiab] AND knee osteoarthritis[tiab] AND randomized controlled trial[pt]", "retatrutide": "retatrutide[tiab] AND (osteoarthritis[tiab] OR knee[tiab])", "incretin_rct": "(tirzepatide[tiab] OR semaglutide[tiab]) AND osteoarthritis[tiab] AND randomized controlled trial[pt]", "acr_2026": "\"American College of Rheumatology\"[tiab] AND osteoarthritis[ti] AND (guideline[ti] OR recommendations[ti]) AND 2026[dp] -> 0 records", "guidelines_edat": "osteoarthritis[ti] AND (guideline[ti] OR recommendations[ti]) AND 2026/08/01:2026/10/15[edat] -> 6 records", "society_guidelines_edat": "(OARSI[tiab] OR EULAR[tiab] OR NICE[tiab] OR ESCEO[tiab]) AND osteoarthritis[tiab] AND (recommendation*[ti] OR guideline*[ti]) AND 2026/08/28:2026/10/15[edat] -> 0 records", "aaos_hip_doi": "10.5435/JAAOS-D-24-00420[doi] -> 38781351" }, "cochrane_cdsr": { "pubmed_dp": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND 2026/08/28:2026/10/15[dp]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND 2026/08/28:2026/10/15[Date - Publication]", "count": 0, "ids": [] }, "pubmed_edat": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (osteoarthritis[tiab] OR osteoarthritis[mh]) AND 2026/08/28:2026/10/15[edat]", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"osteoarthritis\"[Title/Abstract] OR \"osteoarthritis\"[MeSH Terms]) AND 2026/08/28:2026/10/15[Date - Entry]", "count": 0, "ids": [] }, "europe_pmc": { "query": "JOURNAL:\"Cochrane Database Syst Rev\" AND (osteoarthritis OR arthroplasty OR \"knee pain\" OR \"hip pain\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-15]", "hitCount": 0 }, "note": "Zero CDSR osteoarthritis records in the window in PubMed (publication and entry date) and Europe PMC. cochranelibrary.com/CENTRAL not searched (HTTP 403 per SOURCES.md)." }, "europe_pmc": { "all_window": { "query": "(TITLE:\"osteoarthritis\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-15]", "hitCount": 498, "records": [ { "id": "42785469", "source": "MED", "pmid": "42785469", "doi": "10.1016/j.joca.2026.09.011", "title": "Fundamentals of osteoarthritis: Surgical therapy in osteoarthritis.", "pubType": "review; journal article", "isOpenAccess": "N", "inEPMC": "N", "hasPDF": "N" }, { "id": "42821703", "source": "MED", "pmid": "42821703", "doi": "10.1126/science.ael3784", "title": "Osteoarthritis as a vascular disease.", "pubType": "comment; news", "isOpenAccess": "N", "inEPMC": "N", "hasPDF": "N" }, { "id": "42722058", "source": "MED", "pmid": "42722058", "doi": "10.1016/j.joca.2026.09.003", "title": "Fundamentals of Osteoarthritis 2026: Imaging.", "pubType": "review; journal article", "isOpenAccess": "N", "inEPMC": "N", "hasPDF": "N" }, { "id": "42685225", "source": "MED", "pmid": "42685225", "doi": "10.1126/sciadv.aef9739", "title": "Restoring pre-osteoarthritis cartilage matrix integrity via Col9 mRNA halts osteoarthritis progression.", "pubType": "research-article; journal article", "isOpenAccess": "Y", "inEPMC": "Y", "hasPDF": "Y" }, { "id": "42706131", "source": "MED", "pmid": "42706131", "doi": "10.3760/cma.j.cn112137-20260414-01011", "title": "[Is osteoarthritis merely a local \"wear and tear\" or a systemic disease? :exploration of the pathogenesis and therapeutic strategies for osteoarthritis].", "pubType": "review; journal article; english abstract", "isOpenAccess": "N", "inEPMC": "N", "hasPDF": "N" }, { "id": "PMC13651664", "source": "PMC", "pmid": null, "doi": null, "title": "Translating mechanobiology in osteoarthritis to biomaterial-informed therapeutic strategies", "pubType": "review-article; review; journal article", "isOpenAccess": "Y", "inEPMC": "Y", "hasPDF": "Y" }, { "id": "PMC13650076", "source": "PMC", "pmid": null, "doi": null, "title": "A Metal–Polyphenol Complex Eliminates Chondrocytic ROS to Ameliorate Osteoarthritis", "pubType": "research-article; journal article", "isOpenAccess": "Y", "inEPMC": "Y", "hasPDF": "Y" }, { "id": "42821663", "source": "MED", "pmid": "42821663", "doi": "10.1126/science.aed8207", "title": "Hypertension fuels osteoarthritis through neuroendocrine signaling.", "pubType": "journal article", "isOpenAccess": "N", "inEPMC": "N", "hasPDF": "N" }, { "id": "42762435", "source": "MED", "pmid": "42762435", "doi": "10.1080/21691401.2026.2724794", "title": "Epidemiology and potential mechanisms of structural progression in osteoarthritis.", "pubType": "review; journal article", "isOpenAccess": "N", "inEPMC": "N", "hasPDF": "N" }, { "id": "PMC13652550", "source": "PMC", "pmid": null, "doi": null, "title": "Cardiovascular Comorbidities in Knee Osteoarthritis: Prevalence, Functional association, and Therapeutic Consequences", "pubType": "research-article; journal article", "isOpenAccess": "Y", "inEPMC": "Y", "hasPDF": "Y" }, { "id": "PMC13643906", "source": "PMC", "pmid": null, "doi": null, "title": "Diagnostic agreement of nutritional screening tools in obesity-related knee osteoarthritis", "pubType": "research-article; journal article", "isOpenAccess": "Y", "inEPMC": "Y", "hasPDF": "Y" }, { "id": "42728642", "source": "MED", "pmid": "42728642", "doi": "10.1093/qjmed/hcag236", "title": "Gull-wing Appearance in Erosive Hand Osteoarthritis.", "pubType": "journal article", "isOpenAccess": "N", "inEPMC": "N", "hasPDF": "N" }, { "id": "42827061", "source": "MED", "pmid": "42827061", "doi": "10.1016/j.berh.2026.102204", "title": "Are we at risk of increasing sarcopenia? 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journal article", "isOpenAccess": "Y", "inEPMC": "Y", "hasPDF": "Y" }, { "id": "42671689", "source": "MED", "pmid": "42671689", "doi": "10.1007/s44307-026-00119-6", "title": "MYDGF as a telomerase activator and therapeutic target for osteoarthritis.", "pubType": "research-article; journal article", "isOpenAccess": "Y", "inEPMC": "Y", "hasPDF": "Y" }, { "id": "42772546", "source": "MED", "pmid": "42772546", "doi": "10.1016/j.joca.2026.09.009", "title": "Osteoarthritis service delivery model: Regional care networks.", "pubType": "editorial", "isOpenAccess": "N", "inEPMC": "N", "hasPDF": "N" }, { "id": "42665529", "source": "MED", "pmid": "42665529", "doi": "10.1016/j.surge.2026.07.004", "title": "Arthroscopy of femoroacetabular impingement and osteoarthritis: a systematic review.", "pubType": "review; journal article", "isOpenAccess": "N", "inEPMC": "N", "hasPDF": "N" }, { "id": "42792240", "source": "MED", "pmid": "42792240", "doi": "10.3390/antiox15091202", "title": "Redox-Regulating Propolis- and Honey-Containing Hydrogels in Osteoarthritis.", "pubType": "review-article; 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Interpreting pain relief, weight-loss quality, and structural outcomes.", "volume": "", "issue": "", "pages": "", "elocationid": "pii: S1063-4584(26)01048-4. doi: 10.1016/j.joca.2026.09.007" }, "42373005": { "doi": "10.1016/j.joca.2026.06.010", "pubtypes": [ "Journal Article", "Multicenter Study", "Pragmatic Clinical Trial", "Randomized Controlled Trial" ], "pubmed_flags": [], "crossref_updated_by": [], "first_author": "Weber F", "source": "Osteoarthritis Cartilage", "pubdate": "2026 Oct", "title": "Effectiveness of a blended care intervention in physiotherapy with exercise and education for patients with hip or knee osteoarthritis (SmArt-E): A multicentre pragmatic randomized controlled trial.", "volume": "34", "issue": "10", "pages": "1525-1538", "elocationid": "doi: 10.1016/j.joca.2026.06.010" }, "42620719": { "doi": "10.1016/j.lanepe.2026.101800", "pubtypes": [ "Journal Article" ], "pubmed_flags": [], "crossref_updated_by": [], "first_author": "Swain S", "source": "Lancet Reg Health Eur", "pubdate": "2026 Oct", "title": "Associations between osteoarthritis and comorbidities before and after diagnosis across four European primary care databases: a multinational case-control and cohort study.", "volume": "69", "issue": "", "pages": "101800", "elocationid": "doi: 10.1016/j.lanepe.2026.101800" }, "41524479": { "doi": "10.1002/acr.80001", "pubtypes": [ "Journal Article", "Review" ], "pubmed_flags": [], "crossref_updated_by": [], "first_author": "Vecchiarelli C", "source": "Arthritis Care Res (Hoboken)", "pubdate": "2026 Sep", "title": "Conflicts of Interest Reporting in Trials and Guidelines Addressing Glucocorticoid Injections for Knee Osteoarthritis.", "volume": "78", "issue": "9", "pages": "1201-1208", "elocationid": "doi: 10.1002/acr.80001" }, "40156368": { "doi": "10.1177/19476035241286578", "pubtypes": [ "Journal Article", "Consensus Statement", "Practice Guideline" ], "pubmed_flags": [], "crossref_updated_by": [], "first_author": "Monfort J", "source": "Cartilage", "pubdate": "2026 Sep", "title": "EUROVISCO Good Medical Practice Recommendations for the Use of Viscosupplementation with Hyaluronic Acid in the Management of Knee Osteoarthritis.", "volume": "17", "issue": "3", "pages": "322-330", "elocationid": "doi: 10.1177/19476035241286578" }, "42825585": { "doi": "10.5435/JAAOS-D-26-00719", "pubtypes": [ "Journal Article" ], "pubmed_flags": [], "crossref_updated_by": [], "first_author": "Brophy RH", "source": "J Am Acad Orthop Surg", "pubdate": "2026 Oct 15", "title": "AAOS Clinical Practice Guideline Summary: Management of Osteoarthritis of the Knee (Nonarthroplasty), Third Edition: Erratum.", "volume": "34", "issue": "20", "pages": "e2919", "elocationid": "doi: 10.5435/JAAOS-D-26-00719" }, "42825586": { "doi": "10.5435/JAAOS-D-26-00720", "pubtypes": [ "Journal Article", "Published Erratum" ], "pubmed_flags": [], "crossref_updated_by": [], "first_author": "Hannon CP", "source": "J Am Acad Orthop Surg", "pubdate": "2026 Oct 15", "title": "American Academy of Orthopaedic Surgeons Clinical Practice Guideline Summary: Management of Osteoarthritis of the Hip: Erratum.", "volume": "34", "issue": "20", "pages": "e2920", "elocationid": "doi: 10.5435/JAAOS-D-26-00720" }, "42574728": { "doi": "10.7326/ANNALS-26-00710", "pubtypes": [ "Journal Article", "Randomized Controlled Trial", "Equivalence Trial", "Comparative Study" ], "pubmed_flags": [], "crossref_updated_by": [], "first_author": "Miettinen M", "source": "Ann Intern Med", "pubdate": "2026 Sep", "title": "Surgery Versus Watchful Waiting for First Metatarsophalangeal Joint Osteoarthritis : A Randomized Controlled Trial.", "volume": "179", "issue": "9", "pages": "1271-1279", "elocationid": "doi: 10.7326/ANNALS-26-00710" }, "42585691": { "doi": "10.1016/j.crad.2026.107427", "pubtypes": [ "Journal Article", "Randomized Controlled Trial" ], "pubmed_flags": [], "crossref_updated_by": [], "first_author": "Kumar S", "source": "Clin Radiol", "pubdate": "2026 Oct", "title": "Genicular artery embolisation for the management of knee osteoarthritis: a prospective randomised study.", "volume": "101", "issue": "", "pages": "107427", "elocationid": "doi: 10.1016/j.crad.2026.107427" }, "42657310": { "doi": "10.1016/j.ocarto.2026.100861", "pubmed_flags": [], "crossref_updated_by": [] }, "42790728": { "doi": "10.1016/j.joca.2026.09.012", "pubmed_flags": [], "crossref_updated_by": [] }, "38781351": { "doi": "10.5435/JAAOS-D-24-00420", "pubmed_flags": [], "crossref_updated_by": [ [ "correction", "10.5435/jaaos-d-26-00720" ] ] }, "35383651": { "doi": "10.5435/JAAOS-D-21-01233", "pubmed_flags": "not re-fetched as pubtype; existing record", "crossref_updated_by": [ [ "correction", "10.5435/jaaos-d-26-00719" ] ] } }, "web_sources": { "ACR": "https://rheumatology.org/osteoarthritis-guideline (200): '2026 Osteoarthritis Guideline Summary ... Posted September 14, 2026'; summary PDF https://assets.contentstack.io/v3/assets/bltee37abb6b278ab2c/bltb3d12c34020da842/oa-guideline-summary-2026.pdf (200, 4 pages, Board approval 2026-09-08)", "NICE NG226": "https://www.nice.org.uk/guidance/ng226 (200): Published 19 October 2022; Last reviewed 19 October 2022", "OARSI": "https://oarsi.org/research/oarsi-guidelines (404)", "AAOS": "https://www.aaos.org/oak3cpg -> knee CPG PDF (200), not re-read", "Arthritis UK news": "https://www.arthritis-uk.org/news/ (200); in-window item 2026-09-01 Scotland MSK open letter", "Arthritis Foundation news": "https://www.arthritis.org/news (200); no OA-specific in-window item identified", "Unpaywall": "skipped: LIFEBANK_CONTACT_EMAIL unset; Crossref queried without mailto" }, "source_boundaries": "PubMed, Europe PMC, ClinicalTrials.gov v2, Crossref, ISRCTN (page fetch) and official guideline/patient-organisation sites were queried. Cochrane Library/CENTRAL and SciELO/LILACS were not searched (HTTP 403). Absences are PubMed/Europe PMC absences dated 2026-10-15." }