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"2026-07-21", "results_first_posted": "2026-07-21", "results_section_present": true, "primary_completion_date": "2023-12-15", "enrollment": 213, "why_stopped": null, "api_error": null }, { "nct_id": "NCT05107336", "status": "COMPLETED", "last_update_posted": "2025-07-20", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2023-03-21", "enrollment": 44, "why_stopped": null, "api_error": null }, { "nct_id": "NCT05500222", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-07-08", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2026-12", "enrollment": 845, "why_stopped": null, "api_error": null }, { "nct_id": "NCT05519475", "status": "RECRUITING", "last_update_posted": "2026-10-08", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2028-04-27", "enrollment": 120, "why_stopped": null, "api_error": null }, { "nct_id": "NCT05648214", "status": 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"api_error": null }, { "nct_id": "NCT06632444", "status": "RECRUITING", "last_update_posted": "2026-10-14", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2031-12-27", "enrollment": 1800, "why_stopped": null, "api_error": null }, { "nct_id": "NCT06632457", "status": "RECRUITING", "last_update_posted": "2026-10-14", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2029-06-05", "enrollment": 1590, "why_stopped": null, "api_error": null }, { "nct_id": "NCT06671886", "status": "RECRUITING", "last_update_posted": "2025-11-14", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2028-01-31", "enrollment": 32, "why_stopped": null, "api_error": null }, { "nct_id": "NCT06884293", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-05-12", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2026-12-31", "enrollment": 479, "why_stopped": null, "api_error": null }, { "nct_id": "NCT07058155", "status": "RECRUITING", "last_update_posted": "2025-12-23", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2029-02-01", "enrollment": 70, "why_stopped": null, "api_error": null }, { "nct_id": "NCT07165028", "status": "RECRUITING", "last_update_posted": "2026-10-08", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2030-08", "enrollment": 4500, "why_stopped": null, "api_error": null }, { "nct_id": "NCT07221188", "status": "RECRUITING", "last_update_posted": "2026-09-17", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2028-03-24", "enrollment": 1250, "why_stopped": null, "api_error": null }, { "nct_id": "NCT07221227", "status": "RECRUITING", "last_update_posted": "2026-07-27", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2028-03-29", "enrollment": 1200, "why_stopped": null, "api_error": null }, { "nct_id": "NCT07265297", "status": "RECRUITING", "last_update_posted": "2025-12-04", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2030-12-31", "enrollment": 210, "why_stopped": null, "api_error": null }, { "nct_id": "NCT07527910", "status": "RECRUITING", "last_update_posted": "2026-09-29", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2030-03-15", "enrollment": 204, "why_stopped": null, "api_error": null }, { "nct_id": "NCT07570810", "status": "NOT_YET_RECRUITING", "last_update_posted": "2026-05-06", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2026-11-30", "enrollment": 30, "why_stopped": null, "api_error": null }, { "nct_id": "NCT07701993", "status": "RECRUITING", "last_update_posted": "2026-09-30", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2033-06-23", "enrollment": 1740, "why_stopped": null, "api_error": null }, { "nct_id": "NCT07704892", "status": "RECRUITING", "last_update_posted": "2026-09-30", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2030-10-16", "enrollment": 380, "why_stopped": null, "api_error": null }, { "nct_id": "NCT07795164", "status": "RECRUITING", "last_update_posted": "2026-09-23", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2028-12", "enrollment": 1800, "why_stopped": null, "api_error": null }, { "nct_id": "NCT06168383", "status": "COMPLETED", "last_update_posted": "2026-06-23", "results_first_posted": null, "results_section_present": false, "primary_completion_date": "2025-12-12", "enrollment": 186, "why_stopped": null, "api_error": null, "note": "Fetched 2026-10-18; not previously cited by this condition. Linked publication PMID 42887516." } ], "watch": { "NCT05500222": { "nct": "NCT05500222", "title": "A Phase 3 Study to Evaluate the Effect of Resmetirom on Clinical Outcomes in Patients With Well-compensated NASH Cirrhosis (MAESTRO-NASH-OUTCOMES)", "status": "ACTIVE_NOT_RECRUITING", "has_results": false, "results_first_post": null, "last_update": "2026-07-08", "primary_completion": "2026-12", "completion": "2027-01", "enrollment": 845, "phases": [ "PHASE3" ], "why_stopped": null, "sponsor": "Madrigal Pharmaceuticals, Inc." }, "NCT03900429": { "nct": "NCT03900429", "title": "A Phase 3 Study to Evaluate the Efficacy and Safety of MGL-3196 (Resmetirom) in Patients With NASH and Fibrosis", "status": "ACTIVE_NOT_RECRUITING", "has_results": false, "results_first_post": null, "last_update": "2026-06-01", "primary_completion": "2028-01", "completion": "2028-01", "enrollment": 1759, "phases": [ "PHASE3" ], "why_stopped": null, "sponsor": "Madrigal Pharmaceuticals, Inc." }, "NCT04822181": { "nct": "NCT04822181", "title": "Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)", "status": "ACTIVE_NOT_RECRUITING", "has_results": false, "results_first_post": null, "last_update": "2026-10-13", "primary_completion": "2029-04-25", "completion": "2029-04-25", "enrollment": 1205, "phases": [ "PHASE3" ], "why_stopped": null, "sponsor": "Novo Nordisk A/S" }, "NCT05809934": { "nct": "NCT05809934", "title": "A Study to Evaluate AZD2693 in Participants Who Are Carriers of the PNPLA3 148M Risk Allele With Non-cirrhotic Non-alcoholic Steatohepatitis With Fibrosis", "status": "COMPLETED", "has_results": false, "results_first_post": null, "last_update": "2025-10-28", "primary_completion": "2025-07-14", "completion": "2025-09-29", "enrollment": 220, "phases": [ "PHASE2" ], "why_stopped": null, "sponsor": "AstraZeneca" }, "NCT04565717": { "nct": "NCT04565717", "title": "A Study of ALN-HSD in Healthy Adult Subjects and Adult Patients With Nonalcoholic Steatohepatitis (NASH)", "status": "TERMINATED", "has_results": false, "results_first_post": null, "last_update": "2024-05-17", "primary_completion": "2023-01-06", "completion": "2023-12-21", "enrollment": 6, "phases": [ "PHASE1" ], "why_stopped": "Study ALN-HSD-001 was terminated due to business reasons and changes in the development strategy of the product. No safety issues were found.", "sponsor": "Alnylam Pharmaceuticals" }, "NCT05519475": { "nct": "NCT05519475", "title": "A Precision Medicine Approach Using Gene Silencing to Treat a Chronic Liver Disease Called Metabolic Dysfunction-Associated Steatohepatitis (MASH) in Adult Participants at Increased Genetic Risk for This Condition", "status": "RECRUITING", "has_results": false, "results_first_post": null, "last_update": "2026-10-08", "primary_completion": "2028-04-27", "completion": "2028-12-07", "enrollment": 120, "phases": [ "PHASE2" ], "why_stopped": null, "sponsor": "Regeneron Pharmaceuticals" }, "NCT06374875": { "nct": "NCT06374875", "title": "Fibrosis Lessens After Metabolic Surgery", "status": "RECRUITING", "has_results": false, "results_first_post": null, "last_update": "2026-07-31", "primary_completion": "2029-05-31", "completion": "2029-12-31", "enrollment": 120, "phases": [ "PHASE4" ], "why_stopped": null, "sponsor": "The Cleveland Clinic" } }, "triage": { "wiki": [ "42887516", "42869334" ], "bibliography_only": [ "42880865", "42879243", "42873450" ], "deferred_no_abstract": [ "42850047" ], "expression_of_concern_not_in_corpus": [ "42872615" ], "landmark_notes": [] }, "limitations": [ "Cochrane Library website (CENTRAL) returned HTTP 403; CDSR was searched via PubMed journal filter only.", "SciELO search.scielo.org returned HTTP 403. LILACS lilacs.bvsalud.org timed out. No absence claim about Latin American regional literature is made.", "WHO ICTRP portal returned HTTP 200 but is JS-driven; no programmatic trial search was completed there. ISRCTN REST API was queried and returned 0 records lastUpdated 2026-10-07 to 2026-10-18 for MASLD/NAFLD/NASH/MASH.", "Unpaywall skipped because LIFEBANK_CONTACT_EMAIL is unset; Crossref queried without mailto.", "ADA Standards pages returned HTTP 403 (Cloudflare). NICE NG49, AASLD, EASL, APASL, ALEH, KASL homepages returned 200; no new dated society guideline survived triage.", "Europe PMC free-text retrieval contains irrelevant acronym matches; hit counts are unfiltered database results.", "PMID 42850047 (PEth) still has no PubMed abstract; findings not inferred." ] }