{
  "condition": "hypertensive-heart-disease",
  "sweep_date": "2026-10-20",
  "window": {
    "from": "2026-08-28",
    "to": "2026-10-20",
    "pubmed_date_field": "Date - Publication",
    "europe_pmc_date_field": "FIRST_PDATE"
  },
  "pubmed": [
    {
      "topic": "nosology-burden",
      "query": "((\"hypertensive heart disease\"[tiab] OR \"Hypertensive Heart Disease\"[Mesh])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28%22hypertensive+heart+disease%22%5Btiab%5D+OR+%22Hypertensive+Heart+Disease%22%5BMesh%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 26,
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        "42622622",
        "42554265",
        "42475976",
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        "42162768",
        "41954269"
      ],
      "query_translation": "\"hypertensive heart disease\"[Title/Abstract] AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "remodeling",
      "query": "(hypertens*[tiab] AND (\"left ventricular hypertrophy\"[tiab] OR \"cardiac remodeling\"[tiab] OR \"myocardial fibrosis\"[tiab] OR \"ventricular mass\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28hypertens%2A%5Btiab%5D+AND+%28%22left+ventricular+hypertrophy%22%5Btiab%5D+OR+%22cardiac+remodeling%22%5Btiab%5D+OR+%22myocardial+fibrosis%22%5Btiab%5D+OR+%22ventricular+mass%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 104,
      "ids": [
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        "42083154",
        "42043771",
        "41843130",
        "41782336",
        "41642558",
        "41528452"
      ],
      "query_translation": "\"hypertens*\"[Title/Abstract] AND (\"left ventricular hypertrophy\"[Title/Abstract] OR \"cardiac remodeling\"[Title/Abstract] OR \"myocardial fibrosis\"[Title/Abstract] OR \"ventricular mass\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "diagnosis-biomarkers",
      "query": "(hypertens*[tiab] AND (\"cardiac magnetic resonance\"[tiab] OR \"global longitudinal strain\"[tiab] OR NT-proBNP[tiab] OR \"cardiac troponin\"[tiab] OR \"ECG-LVH\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28hypertens%2A%5Btiab%5D+AND+%28%22cardiac+magnetic+resonance%22%5Btiab%5D+OR+%22global+longitudinal+strain%22%5Btiab%5D+OR+NT-proBNP%5Btiab%5D+OR+%22cardiac+troponin%22%5Btiab%5D+OR+%22ECG-LVH%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 98,
      "ids": [
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        "42103091",
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        "41955621",
        "41528452",
        "41528064"
      ],
      "query_translation": "\"hypertens*\"[Title/Abstract] AND (\"cardiac magnetic resonance\"[Title/Abstract] OR \"global longitudinal strain\"[Title/Abstract] OR \"NT-proBNP\"[Title/Abstract] OR \"cardiac troponin\"[Title/Abstract] OR \"ECG-LVH\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "hfprevention",
      "query": "((hypertens*[tiab] OR \"blood pressure\"[tiab]) AND (HFpEF[tiab] OR \"heart failure with preserved\"[tiab] OR \"pre-heart failure\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28hypertens%2A%5Btiab%5D+OR+%22blood+pressure%22%5Btiab%5D%29+AND+%28HFpEF%5Btiab%5D+OR+%22heart+failure+with+preserved%22%5Btiab%5D+OR+%22pre-heart+failure%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 67,
      "ids": [
        "42895302",
        "42894960",
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        "42877728",
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      "query_translation": "(\"hypertens*\"[Title/Abstract] OR \"blood pressure\"[Title/Abstract]) AND (\"HFpEF\"[Title/Abstract] OR \"heart failure with preserved\"[Title/Abstract] OR \"pre-heart failure\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "bp-targets",
      "query": "((\"blood pressure\"[tiab] OR hypertens*[tiab]) AND (\"intensive treatment\"[tiab] OR \"intensive control\"[tiab] OR \"blood pressure target\"[tiab] OR \"blood pressure targets\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28%22blood+pressure%22%5Btiab%5D+OR+hypertens%2A%5Btiab%5D%29+AND+%28%22intensive+treatment%22%5Btiab%5D+OR+%22intensive+control%22%5Btiab%5D+OR+%22blood+pressure+target%22%5Btiab%5D+OR+%22blood+pressure+targets%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 53,
      "ids": [
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        "42656614",
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        "42187283",
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        "42046534",
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      ],
      "query_translation": "(\"blood pressure\"[Title/Abstract] OR \"hypertens*\"[Title/Abstract]) AND (\"intensive treatment\"[Title/Abstract] OR \"intensive control\"[Title/Abstract] OR \"blood pressure target\"[Title/Abstract] OR \"blood pressure targets\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "pharmacologic",
      "query": "(hypertens*[tiab] AND (baxdrostat[tiab] OR lorundrostat[tiab] OR \"aldosterone synthase\"[tiab] OR \"sacubitril\"[tiab] OR \"spironolactone\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28hypertens%2A%5Btiab%5D+AND+%28baxdrostat%5Btiab%5D+OR+lorundrostat%5Btiab%5D+OR+%22aldosterone+synthase%22%5Btiab%5D+OR+%22sacubitril%22%5Btiab%5D+OR+%22spironolactone%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 66,
      "ids": [
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        "42891596",
        "42851567",
        "42847230",
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      ],
      "query_translation": "\"hypertens*\"[Title/Abstract] AND (\"baxdrostat\"[Title/Abstract] OR \"lorundrostat\"[Title/Abstract] OR \"aldosterone synthase\"[Title/Abstract] OR \"sacubitril\"[Title/Abstract] OR \"spironolactone\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "arrhythmia",
      "query": "((hypertens*[tiab] OR \"blood pressure\"[tiab]) AND (\"atrial remodeling\"[tiab] OR \"atrial fibrillation\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28hypertens%2A%5Btiab%5D+OR+%22blood+pressure%22%5Btiab%5D%29+AND+%28%22atrial+remodeling%22%5Btiab%5D+OR+%22atrial+fibrillation%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 185,
      "ids": [
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        "42585567",
        "42569984",
        "42568307",
        "42537394",
        "42532455",
        "42532346",
        "42517908",
        "42501030",
        "42485689",
        "42478834",
        "42473796",
        "42471939",
        "42470418",
        "42458174",
        "42417042",
        "42417034",
        "42409661",
        "42364820",
        "42364704",
        "42362815",
        "42342032",
        "42312499",
        "42303451",
        "42269357",
        "42240851",
        "42218046",
        "42171672",
        "42133276",
        "42107758",
        "42092450",
        "42066879",
        "42053472",
        "42031586",
        "42025692",
        "42012487",
        "42001249",
        "41954269",
        "41887445",
        "41863723",
        "41851058",
        "41845150",
        "41818712",
        "41816552",
        "41713699",
        "41605626",
        "41494933",
        "41478588",
        "41237814",
        "41077371",
        "40111443"
      ],
      "query_translation": "(\"hypertens*\"[Title/Abstract] OR \"blood pressure\"[Title/Abstract]) AND (\"atrial remodeling\"[Title/Abstract] OR \"atrial fibrillation\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "secondary-modifiers",
      "query": "((\"primary aldosteronism\"[tiab] OR \"resistant hypertension\"[tiab] OR (hypertens*[tiab] AND \"sleep apnea\"[tiab])) AND (cardiac[tiab] OR cardiovascular[tiab] OR heart[tiab] OR trial[tiab] OR meta-analysis[pt])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28%22primary+aldosteronism%22%5Btiab%5D+OR+%22resistant+hypertension%22%5Btiab%5D+OR+%28hypertens%2A%5Btiab%5D+AND+%22sleep+apnea%22%5Btiab%5D%29%29+AND+%28cardiac%5Btiab%5D+OR+cardiovascular%5Btiab%5D+OR+heart%5Btiab%5D+OR+trial%5Btiab%5D+OR+meta-analysis%5Bpt%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 128,
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      "query_translation": "(\"primary aldosteronism\"[Title/Abstract] OR \"resistant hypertension\"[Title/Abstract] OR (\"hypertens*\"[Title/Abstract] AND \"sleep apnea\"[Title/Abstract])) AND (\"cardiac\"[Title/Abstract] OR \"cardiovascular\"[Title/Abstract] OR \"heart\"[Title/Abstract] OR \"trial\"[Title/Abstract] OR \"meta-analysis\"[Publication Type]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "lifestyle-population",
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      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28hypertens%2A%5Btiab%5D+AND+%28%22salt+substitute%22%5Btiab%5D+OR+DASH%5Btiab%5D+OR+%22community+health+worker%22%5Btiab%5D+OR+%22village+doctor%22%5Btiab%5D+OR+%22sodium+reduction%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 52,
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      "query_translation": "\"hypertens*\"[Title/Abstract] AND (\"salt substitute\"[Title/Abstract] OR \"DASH\"[Title/Abstract] OR \"community health worker\"[Title/Abstract] OR \"village doctor\"[Title/Abstract] OR \"sodium reduction\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]"
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    {
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    },
    {
      "topic": "burden-statistics",
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      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28%22hypertensive+heart+disease%22%5Btiab%5D+OR+%28hypertension%5Btiab%5D+AND+%28%22global+burden%22%5Btiab%5D+OR+%22population-based%22%5Btiab%5D+OR+registry%5Btiab%5D%29%29%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 317,
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      "query_translation": "(\"hypertensive heart disease\"[Title/Abstract] OR (\"hypertension\"[Title/Abstract] AND (\"global burden\"[Title/Abstract] OR \"population-based\"[Title/Abstract] OR \"registry\"[Title/Abstract]))) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "patient-experience",
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      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28hypertens%2A%5Btiab%5D+AND+%28qualitative%5Btiab%5D+OR+%22patient+experience%22%5Btiab%5D+OR+%22patient-reported%22%5Btiab%5D+OR+%22lived+experience%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 96,
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        "42585567",
        "42576655",
        "42536291",
        "42518702",
        "42425312",
        "42402755",
        "42397945",
        "42335504",
        "42323885",
        "42323480",
        "42295828",
        "42272165",
        "42223807",
        "42080889",
        "42031036",
        "41677016",
        "41530631",
        "41442275",
        "41423773",
        "40694664"
      ],
      "query_translation": "\"hypertens*\"[Title/Abstract] AND (\"qualitative\"[Title/Abstract] OR \"patient experience\"[Title/Abstract] OR \"patient-reported\"[Title/Abstract] OR \"lived experience\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "safety",
      "query": "((\"hypertensive emergency\"[tiab] OR \"hypertensive emergencies\"[tiab] OR (\"intensive blood pressure\"[tiab] AND (harm*[tiab] OR \"kidney injury\"[tiab] OR hypotension[tiab])))) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28%22hypertensive+emergency%22%5Btiab%5D+OR+%22hypertensive+emergencies%22%5Btiab%5D+OR+%28%22intensive+blood+pressure%22%5Btiab%5D+AND+%28harm%2A%5Btiab%5D+OR+%22kidney+injury%22%5Btiab%5D+OR+hypotension%5Btiab%5D%29%29%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 21,
      "ids": [
        "42862110",
        "42846271",
        "42844194",
        "42838972",
        "42830886",
        "42788430",
        "42754843",
        "42749883",
        "42732683",
        "42720655",
        "42700009",
        "42695670",
        "42686811",
        "42666029",
        "42645558",
        "42518702",
        "42500494",
        "42495732",
        "42132453",
        "42129062",
        "42068363"
      ],
      "query_translation": "(\"hypertensive emergency\"[Title/Abstract] OR \"hypertensive emergencies\"[Title/Abstract] OR (\"intensive blood pressure\"[Title/Abstract] AND (\"harm*\"[Title/Abstract] OR \"kidney injury\"[Title/Abstract] OR \"hypotension\"[Title/Abstract]))) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "renal-denervation",
      "query": "(\"renal denervation\"[tiab]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22renal+denervation%22%5Btiab%5D%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 49,
      "ids": [
        "42889948",
        "42886134",
        "42877893",
        "42876404",
        "42860163",
        "42855522",
        "42853227",
        "42846707",
        "42832922",
        "42831847",
        "42826060",
        "42821223",
        "42816630",
        "42810479",
        "42807709",
        "42802228",
        "42797050",
        "42788623",
        "42783050",
        "42775984",
        "42763807",
        "42747641",
        "42745542",
        "42736942",
        "42736668",
        "31869068",
        "42730399",
        "42707347",
        "42704524",
        "42681840",
        "42668881",
        "42666822",
        "42662851",
        "42623957",
        "42552252",
        "42527205",
        "42504620",
        "42501241",
        "42448569",
        "42396775",
        "42362815",
        "42323480",
        "42319791",
        "42302401",
        "42246571",
        "42228047",
        "42191019",
        "41485942",
        "41222588"
      ],
      "query_translation": "\"renal denervation\"[Title/Abstract] AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "outcomes",
      "query": "(hypertens*[tiab] AND (\"heart failure\"[tiab] OR \"cardiovascular events\"[tiab]) AND (\"risk prediction\"[tiab] OR \"risk stratification\"[tiab] OR staging[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28hypertens%2A%5Btiab%5D+AND+%28%22heart+failure%22%5Btiab%5D+OR+%22cardiovascular+events%22%5Btiab%5D%29+AND+%28%22risk+prediction%22%5Btiab%5D+OR+%22risk+stratification%22%5Btiab%5D+OR+staging%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 76,
      "ids": [
        "42895254",
        "42889009",
        "42885794",
        "42882305",
        "42882226",
        "42877728",
        "42865761",
        "42865589",
        "42862908",
        "42862309",
        "42859717",
        "42857498",
        "42855401",
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        "42847229",
        "42831220",
        "42829622",
        "42822601",
        "42819449",
        "42816405",
        "42808453",
        "42807163",
        "42793750",
        "42788450",
        "42764887",
        "42764374",
        "42762227",
        "42760233",
        "42745330",
        "42743071",
        "42741979",
        "42739694",
        "42736131",
        "42735847",
        "42733672",
        "42731863",
        "42731860",
        "42727630",
        "42727188",
        "42724556",
        "42722265",
        "42704813",
        "42701549",
        "42693930",
        "42684644",
        "42683531",
        "42671970",
        "42671364",
        "42669762",
        "42665291",
        "42661244",
        "42641806",
        "42637491",
        "42595241",
        "42556210",
        "42552399",
        "42471062",
        "42437203",
        "42397207",
        "42394266",
        "42364704",
        "42284132",
        "42246897",
        "42218046",
        "42213742",
        "42066879",
        "42031036",
        "41961372",
        "41818712",
        "41810943",
        "41661447",
        "41504608",
        "41472344",
        "41250793",
        "41237814",
        "41137465"
      ],
      "query_translation": "\"hypertens*\"[Title/Abstract] AND (\"heart failure\"[Title/Abstract] OR \"cardiovascular events\"[Title/Abstract]) AND (\"risk prediction\"[Title/Abstract] OR \"risk stratification\"[Title/Abstract] OR \"staging\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-nosology-burden",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"hypertensive heart disease\"[tiab] OR \"Hypertensive Heart Disease\"[Mesh])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28%28%22hypertensive+heart+disease%22%5Btiab%5D+OR+%22Hypertensive+Heart+Disease%22%5BMesh%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND \"hypertensive heart disease\"[Title/Abstract] AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-remodeling",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (hypertens*[tiab] AND (\"left ventricular hypertrophy\"[tiab] OR \"cardiac remodeling\"[tiab] OR \"myocardial fibrosis\"[tiab] OR \"ventricular mass\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28hypertens%2A%5Btiab%5D+AND+%28%22left+ventricular+hypertrophy%22%5Btiab%5D+OR+%22cardiac+remodeling%22%5Btiab%5D+OR+%22myocardial+fibrosis%22%5Btiab%5D+OR+%22ventricular+mass%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"hypertens*\"[Title/Abstract] AND (\"left ventricular hypertrophy\"[Title/Abstract] OR \"cardiac remodeling\"[Title/Abstract] OR \"myocardial fibrosis\"[Title/Abstract] OR \"ventricular mass\"[Title/Abstract])) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-diagnosis-biomarkers",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (hypertens*[tiab] AND (\"cardiac magnetic resonance\"[tiab] OR \"global longitudinal strain\"[tiab] OR NT-proBNP[tiab] OR \"cardiac troponin\"[tiab] OR \"ECG-LVH\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28hypertens%2A%5Btiab%5D+AND+%28%22cardiac+magnetic+resonance%22%5Btiab%5D+OR+%22global+longitudinal+strain%22%5Btiab%5D+OR+NT-proBNP%5Btiab%5D+OR+%22cardiac+troponin%22%5Btiab%5D+OR+%22ECG-LVH%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"hypertens*\"[Title/Abstract] AND (\"cardiac magnetic resonance\"[Title/Abstract] OR \"global longitudinal strain\"[Title/Abstract] OR \"NT-proBNP\"[Title/Abstract] OR \"cardiac troponin\"[Title/Abstract] OR \"ECG-LVH\"[Title/Abstract])) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-hfprevention",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((hypertens*[tiab] OR \"blood pressure\"[tiab]) AND (HFpEF[tiab] OR \"heart failure with preserved\"[tiab] OR \"pre-heart failure\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28%28hypertens%2A%5Btiab%5D+OR+%22blood+pressure%22%5Btiab%5D%29+AND+%28HFpEF%5Btiab%5D+OR+%22heart+failure+with+preserved%22%5Btiab%5D+OR+%22pre-heart+failure%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertens*\"[Title/Abstract] OR \"blood pressure\"[Title/Abstract]) AND (\"HFpEF\"[Title/Abstract] OR \"heart failure with preserved\"[Title/Abstract] OR \"pre-heart failure\"[Title/Abstract])) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-bp-targets",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"blood pressure\"[tiab] OR hypertens*[tiab]) AND (\"intensive treatment\"[tiab] OR \"intensive control\"[tiab] OR \"blood pressure target\"[tiab] OR \"blood pressure targets\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28%28%22blood+pressure%22%5Btiab%5D+OR+hypertens%2A%5Btiab%5D%29+AND+%28%22intensive+treatment%22%5Btiab%5D+OR+%22intensive+control%22%5Btiab%5D+OR+%22blood+pressure+target%22%5Btiab%5D+OR+%22blood+pressure+targets%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 2,
      "ids": [
        "42861682",
        "42788405"
      ],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"blood pressure\"[Title/Abstract] OR \"hypertens*\"[Title/Abstract]) AND (\"intensive treatment\"[Title/Abstract] OR \"intensive control\"[Title/Abstract] OR \"blood pressure target\"[Title/Abstract] OR \"blood pressure targets\"[Title/Abstract])) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-pharmacologic",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (hypertens*[tiab] AND (baxdrostat[tiab] OR lorundrostat[tiab] OR \"aldosterone synthase\"[tiab] OR \"sacubitril\"[tiab] OR \"spironolactone\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28hypertens%2A%5Btiab%5D+AND+%28baxdrostat%5Btiab%5D+OR+lorundrostat%5Btiab%5D+OR+%22aldosterone+synthase%22%5Btiab%5D+OR+%22sacubitril%22%5Btiab%5D+OR+%22spironolactone%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"hypertens*\"[Title/Abstract] AND (\"baxdrostat\"[Title/Abstract] OR \"lorundrostat\"[Title/Abstract] OR \"aldosterone synthase\"[Title/Abstract] OR \"sacubitril\"[Title/Abstract] OR \"spironolactone\"[Title/Abstract])) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-arrhythmia",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((hypertens*[tiab] OR \"blood pressure\"[tiab]) AND (\"atrial remodeling\"[tiab] OR \"atrial fibrillation\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28%28hypertens%2A%5Btiab%5D+OR+%22blood+pressure%22%5Btiab%5D%29+AND+%28%22atrial+remodeling%22%5Btiab%5D+OR+%22atrial+fibrillation%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertens*\"[Title/Abstract] OR \"blood pressure\"[Title/Abstract]) AND (\"atrial remodeling\"[Title/Abstract] OR \"atrial fibrillation\"[Title/Abstract])) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-secondary-modifiers",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"primary aldosteronism\"[tiab] OR \"resistant hypertension\"[tiab] OR (hypertens*[tiab] AND \"sleep apnea\"[tiab])) AND (cardiac[tiab] OR cardiovascular[tiab] OR heart[tiab] OR trial[tiab] OR meta-analysis[pt])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28%28%22primary+aldosteronism%22%5Btiab%5D+OR+%22resistant+hypertension%22%5Btiab%5D+OR+%28hypertens%2A%5Btiab%5D+AND+%22sleep+apnea%22%5Btiab%5D%29%29+AND+%28cardiac%5Btiab%5D+OR+cardiovascular%5Btiab%5D+OR+heart%5Btiab%5D+OR+trial%5Btiab%5D+OR+meta-analysis%5Bpt%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"primary aldosteronism\"[Title/Abstract] OR \"resistant hypertension\"[Title/Abstract] OR (\"hypertens*\"[Title/Abstract] AND \"sleep apnea\"[Title/Abstract])) AND (\"cardiac\"[Title/Abstract] OR \"cardiovascular\"[Title/Abstract] OR \"heart\"[Title/Abstract] OR \"trial\"[Title/Abstract] OR \"meta-analysis\"[Publication Type])) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-lifestyle-population",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (hypertens*[tiab] AND (\"salt substitute\"[tiab] OR DASH[tiab] OR \"community health worker\"[tiab] OR \"village doctor\"[tiab] OR \"sodium reduction\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28hypertens%2A%5Btiab%5D+AND+%28%22salt+substitute%22%5Btiab%5D+OR+DASH%5Btiab%5D+OR+%22community+health+worker%22%5Btiab%5D+OR+%22village+doctor%22%5Btiab%5D+OR+%22sodium+reduction%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"hypertens*\"[Title/Abstract] AND (\"salt substitute\"[Title/Abstract] OR \"DASH\"[Title/Abstract] OR \"community health worker\"[Title/Abstract] OR \"village doctor\"[Title/Abstract] OR \"sodium reduction\"[Title/Abstract])) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-guidelines",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((hypertens*[tiab] OR \"heart failure\"[tiab] OR \"cardiovascular disease and chronic kidney disease\"[tiab]) AND (guideline[pt] OR practice guideline[pt] OR \"consensus\"[ti] OR \"guideline\"[ti] OR \"guidelines\"[ti] OR \"decision pathway\"[ti])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28%28hypertens%2A%5Btiab%5D+OR+%22heart+failure%22%5Btiab%5D+OR+%22cardiovascular+disease+and+chronic+kidney+disease%22%5Btiab%5D%29+AND+%28guideline%5Bpt%5D+OR+practice+guideline%5Bpt%5D+OR+%22consensus%22%5Bti%5D+OR+%22guideline%22%5Bti%5D+OR+%22guidelines%22%5Bti%5D+OR+%22decision+pathway%22%5Bti%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertens*\"[Title/Abstract] OR \"heart failure\"[Title/Abstract]) AND (\"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"consensus\"[Title] OR \"guideline\"[Title] OR \"guidelines\"[Title] OR \"decision pathway\"[Title])) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-burden-statistics",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"hypertensive heart disease\"[tiab] OR (hypertension[tiab] AND (\"global burden\"[tiab] OR \"population-based\"[tiab] OR registry[tiab])))) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28%28%22hypertensive+heart+disease%22%5Btiab%5D+OR+%28hypertension%5Btiab%5D+AND+%28%22global+burden%22%5Btiab%5D+OR+%22population-based%22%5Btiab%5D+OR+registry%5Btiab%5D%29%29%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"hypertensive heart disease\"[Title/Abstract] OR (\"hypertension\"[Title/Abstract] AND (\"global burden\"[Title/Abstract] OR \"population-based\"[Title/Abstract] OR \"registry\"[Title/Abstract]))) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-patient-experience",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (hypertens*[tiab] AND (qualitative[tiab] OR \"patient experience\"[tiab] OR \"patient-reported\"[tiab] OR \"lived experience\"[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28hypertens%2A%5Btiab%5D+AND+%28qualitative%5Btiab%5D+OR+%22patient+experience%22%5Btiab%5D+OR+%22patient-reported%22%5Btiab%5D+OR+%22lived+experience%22%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"hypertens*\"[Title/Abstract] AND (\"qualitative\"[Title/Abstract] OR \"patient experience\"[Title/Abstract] OR \"patient-reported\"[Title/Abstract] OR \"lived experience\"[Title/Abstract])) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-safety",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"hypertensive emergency\"[tiab] OR \"hypertensive emergencies\"[tiab] OR (\"intensive blood pressure\"[tiab] AND (harm*[tiab] OR \"kidney injury\"[tiab] OR hypotension[tiab])))) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28%28%22hypertensive+emergency%22%5Btiab%5D+OR+%22hypertensive+emergencies%22%5Btiab%5D+OR+%28%22intensive+blood+pressure%22%5Btiab%5D+AND+%28harm%2A%5Btiab%5D+OR+%22kidney+injury%22%5Btiab%5D+OR+hypotension%5Btiab%5D%29%29%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"hypertensive emergency\"[Title/Abstract] OR \"hypertensive emergencies\"[Title/Abstract] OR (\"intensive blood pressure\"[Title/Abstract] AND (\"harm*\"[Title/Abstract] OR \"kidney injury\"[Title/Abstract] OR \"hypotension\"[Title/Abstract]))) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-renal-denervation",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"renal denervation\"[tiab]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28%22renal+denervation%22%5Btiab%5D%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND \"renal denervation\"[Title/Abstract] AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-outcomes",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (hypertens*[tiab] AND (\"heart failure\"[tiab] OR \"cardiovascular events\"[tiab]) AND (\"risk prediction\"[tiab] OR \"risk stratification\"[tiab] OR staging[tiab])) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28hypertens%2A%5Btiab%5D+AND+%28%22heart+failure%22%5Btiab%5D+OR+%22cardiovascular+events%22%5Btiab%5D%29+AND+%28%22risk+prediction%22%5Btiab%5D+OR+%22risk+stratification%22%5Btiab%5D+OR+staging%5Btiab%5D%29%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 0,
      "ids": [],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"hypertens*\"[Title/Abstract] AND (\"heart failure\"[Title/Abstract] OR \"cardiovascular events\"[Title/Abstract]) AND (\"risk prediction\"[Title/Abstract] OR \"risk stratification\"[Title/Abstract] OR \"staging\"[Title/Abstract])) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "cochrane-broad",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (hypertension OR \"blood pressure\" OR \"left ventricular hypertrophy\" OR HFpEF OR \"heart failure\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28hypertension+OR+%22blood+pressure%22+OR+%22left+ventricular+hypertrophy%22+OR+HFpEF+OR+%22heart+failure%22%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 5,
      "ids": [
        "42867023",
        "42861682",
        "42788405",
        "42757634",
        "42742033"
      ],
      "query_translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields] OR \"blood pressure\"[All Fields] OR \"left ventricular hypertrophy\"[All Fields] OR \"HFpEF\"[All Fields] OR \"heart failure\"[All Fields]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "asi-human-remodeling",
      "query": "(baxdrostat OR lorundrostat OR dexfadrostat OR vicadrostat OR \"aldosterone synthase inhibitor\") AND (\"left ventricular\" OR LVH OR remodeling OR remodelling OR CMR OR echocardiography OR \"myocardial fibrosis\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28baxdrostat+OR+lorundrostat+OR+dexfadrostat+OR+vicadrostat+OR+%22aldosterone+synthase+inhibitor%22%29+AND+%28%22left+ventricular%22+OR+LVH+OR+remodeling+OR+remodelling+OR+CMR+OR+echocardiography+OR+%22myocardial+fibrosis%22%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 1,
      "ids": [
        "42873316"
      ],
      "query_translation": "(\"baxdrostat\"[Supplementary Concept] OR \"baxdrostat\"[All Fields] OR \"lorundrostat\"[All Fields] OR \"dexfadrostat\"[All Fields] OR \"vicadrostat\"[All Fields] OR \"aldosterone synthase inhibitor\"[All Fields]) AND (\"left ventricular\"[All Fields] OR \"LVH\"[All Fields] OR (\"remodel\"[All Fields] OR \"remodelation\"[All Fields] OR \"remodeled\"[All Fields] OR \"remodeler\"[All Fields] OR \"remodelers\"[All Fields] OR \"remodeling\"[All Fields] OR \"remodelings\"[All Fields] OR \"remodelled\"[All Fields] OR \"remodeller\"[All Fields] OR \"remodellers\"[All Fields] OR \"remodelling\"[All Fields] OR \"remodellings\"[All Fields] OR \"remodels\"[All Fields]) OR (\"remodel\"[All Fields] OR \"remodelation\"[All Fields] OR \"remodeled\"[All Fields] OR \"remodeler\"[All Fields] OR \"remodelers\"[All Fields] OR \"remodeling\"[All Fields] OR \"remodelings\"[All Fields] OR \"remodelled\"[All Fields] OR \"remodeller\"[All Fields] OR \"remodellers\"[All Fields] OR \"remodelling\"[All Fields] OR \"remodellings\"[All Fields] OR \"remodels\"[All Fields]) OR (\"clin med res n y\"[Journal] OR \"calif manage rev\"[Journal] OR \"cmr\"[All Fields]) OR (\"echocardiographies\"[All Fields] OR \"echocardiography\"[MeSH Terms] OR \"echocardiography\"[All Fields]) OR \"myocardial fibrosis\"[All Fields]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "remodel-validation",
      "query": "(REMODEL OR (\"hypertension\" AND (\"NT-proBNP\" OR \"hsTnT\"))) AND (\"external validation\" OR \"independent validation\" OR \"152 pg\" OR \"12.7\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28REMODEL+OR+%28%22hypertension%22+AND+%28%22NT-proBNP%22+OR+%22hsTnT%22%29%29%29+AND+%28%22external+validation%22+OR+%22independent+validation%22+OR+%22152+pg%22+OR+%2212.7%22%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 104,
      "ids": [
        "42894055",
        "42892999",
        "42890793",
        "42886830",
        "42882098",
        "42869881",
        "42869440",
        "42867061",
        "42866356",
        "42864931",
        "42860799",
        "42860598",
        "42857453",
        "42857021",
        "42856962",
        "42856538",
        "42855111",
        "42855076",
        "42854890",
        "42840999",
        "42840869",
        "42835961",
        "42835149",
        "42834860",
        "42830820",
        "42828937",
        "42826363",
        "42825324",
        "42819243",
        "42815746",
        "42815214",
        "42813306",
        "42813249",
        "42810534",
        "42809345",
        "42808034",
        "42801373",
        "42795756",
        "42794582",
        "42794533",
        "42793642",
        "42792820",
        "42792708",
        "42786165",
        "42785488",
        "42782834",
        "42780662",
        "42778889",
        "42777648",
        "42771879",
        "42771286",
        "42769612",
        "42769093",
        "42761222",
        "42754908",
        "42750989",
        "42750328",
        "42747562",
        "42741712",
        "42741187",
        "42740783",
        "42739242",
        "42738883",
        "42738322",
        "42734528",
        "42731315",
        "42725814",
        "42724720",
        "42724634",
        "42724336",
        "42722423",
        "42721533",
        "42708302",
        "42707758",
        "42705456",
        "42702997",
        "42701534",
        "42691216",
        "42687522",
        "42686491",
        "42679892",
        "42674098",
        "42667848",
        "42661111",
        "42655944",
        "42639673",
        "42622088",
        "42617593",
        "42616665",
        "42566074",
        "42526385",
        "42509019",
        "42494174",
        "42480462",
        "42468692",
        "42468141",
        "42365738",
        "42289259",
        "42179976",
        "42174219",
        "42173032",
        "42161016",
        "42157581",
        "42001916"
      ],
      "query_translation": "(\"remodel\"[All Fields] OR \"remodelation\"[All Fields] OR \"remodeled\"[All Fields] OR \"remodeler\"[All Fields] OR \"remodelers\"[All Fields] OR \"remodeling\"[All Fields] OR \"remodelings\"[All Fields] OR \"remodelled\"[All Fields] OR \"remodeller\"[All Fields] OR \"remodellers\"[All Fields] OR \"remodelling\"[All Fields] OR \"remodellings\"[All Fields] OR \"remodels\"[All Fields] OR (\"hypertension\"[All Fields] AND (\"NT-proBNP\"[All Fields] OR \"hsTnT\"[All Fields]))) AND (\"external validation\"[All Fields] OR \"independent validation\"[All Fields] OR \"152 pg\"[All Fields] OR \"12.7\"[All Fields]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "ecglvh-replication",
      "query": "(hypertension OR \"left ventricular hypertrophy\") AND (Johansen OR \"ECG-LVH\" OR \"electrocardiographic criteria\") AND (CMR OR \"magnetic resonance\" OR echocardiography OR \"computed tomography\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28hypertension+OR+%22left+ventricular+hypertrophy%22%29+AND+%28Johansen+OR+%22ECG-LVH%22+OR+%22electrocardiographic+criteria%22%29+AND+%28CMR+OR+%22magnetic+resonance%22+OR+echocardiography+OR+%22computed+tomography%22%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 3,
      "ids": [
        "42885348",
        "42674294",
        "42616978"
      ],
      "query_translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields] OR \"left ventricular hypertrophy\"[All Fields]) AND (\"Johansen\"[All Fields] OR \"ECG-LVH\"[All Fields] OR \"electrocardiographic criteria\"[All Fields]) AND (\"clin med res n y\"[Journal] OR \"calif manage rev\"[Journal] OR \"cmr\"[All Fields] OR \"magnetic resonance\"[All Fields] OR (\"echocardiographies\"[All Fields] OR \"echocardiography\"[MeSH Terms] OR \"echocardiography\"[All Fields]) OR \"computed tomography\"[All Fields]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "ish-guideline",
      "query": "(\"International Society of Hypertension\" AND 2026[dp] AND (guideline[ti] OR guidelines[ti]))",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22International+Society+of+Hypertension%22+AND+2026%5Bdp%5D+AND+%28guideline%5Bti%5D+OR+guidelines%5Bti%5D%29%29&retmode=json&retmax=9999",
      "count": 2,
      "ids": [
        "42554264",
        "40985288"
      ],
      "query_translation": "\"International Society of Hypertension\"[All Fields] AND 2026/01/01:2026/12/31[Date - Publication] AND (\"guideline\"[Title] OR \"guidelines\"[Title])"
    },
    {
      "topic": "spyral-affirm",
      "query": "\"SPYRAL AFFIRM\"",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22SPYRAL+AFFIRM%22&retmode=json&retmax=9999",
      "count": 4,
      "ids": [
        "42637299",
        "42334574",
        "41694452",
        "41852519"
      ],
      "query_translation": "\"spyral\"[All Fields] AND (\"affirm\"[All Fields] OR \"affirmation\"[All Fields] OR \"affirmational\"[All Fields] OR \"affirmations\"[All Fields] OR \"affirmative\"[All Fields] OR \"affirmatively\"[All Fields] OR \"affirmatives\"[All Fields] OR \"affirmed\"[All Fields] OR \"affirming\"[All Fields] OR \"affirms\"[All Fields])"
    },
    {
      "topic": "esc-guideline-records",
      "query": "42661420[uid] OR 42661426[uid]",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=42661420%5Buid%5D+OR+42661426%5Buid%5D&retmode=json&retmax=9999",
      "count": 2,
      "ids": [
        "42661426",
        "42661420"
      ],
      "query_translation": "42661420[UID] OR 42661426[UID]"
    },
    {
      "topic": "remodel-validation-focused",
      "query": "((REMODEL[tiab] AND hypertens*[tiab]) OR (hypertens*[tiab] AND (\"NT-proBNP\"[tiab] OR hsTnT[tiab]))) AND (\"external validation\"[tiab] OR \"independent validation\"[tiab] OR \"152\"[tiab] OR \"12.7\"[tiab]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28REMODEL%5Btiab%5D+AND+hypertens%2A%5Btiab%5D%29+OR+%28hypertens%2A%5Btiab%5D+AND+%28%22NT-proBNP%22%5Btiab%5D+OR+hsTnT%5Btiab%5D%29%29%29+AND+%28%22external+validation%22%5Btiab%5D+OR+%22independent+validation%22%5Btiab%5D+OR+%22152%22%5Btiab%5D+OR+%2212.7%22%5Btiab%5D%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 1,
      "ids": [
        "42857453"
      ],
      "query_translation": "((\"REMODEL\"[Title/Abstract] AND \"hypertens*\"[Title/Abstract]) OR (\"hypertens*\"[Title/Abstract] AND (\"NT-proBNP\"[Title/Abstract] OR \"hsTnT\"[Title/Abstract]))) AND (\"external validation\"[Title/Abstract] OR \"independent validation\"[Title/Abstract] OR \"152\"[Title/Abstract] OR \"12.7\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "asi-human-remodeling-focused",
      "query": "(baxdrostat[tiab] OR lorundrostat[tiab] OR dexfadrostat[tiab] OR vicadrostat[tiab] OR \"aldosterone synthase inhibitor\"[tiab]) AND (\"left ventricular\"[tiab] OR LVH[tiab] OR remodeling[tiab] OR remodelling[tiab] OR CMR[tiab] OR echocardiography[tiab] OR \"myocardial fibrosis\"[tiab]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/20\"[Date - Publication])",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28baxdrostat%5Btiab%5D+OR+lorundrostat%5Btiab%5D+OR+dexfadrostat%5Btiab%5D+OR+vicadrostat%5Btiab%5D+OR+%22aldosterone+synthase+inhibitor%22%5Btiab%5D%29+AND+%28%22left+ventricular%22%5Btiab%5D+OR+LVH%5Btiab%5D+OR+remodeling%5Btiab%5D+OR+remodelling%5Btiab%5D+OR+CMR%5Btiab%5D+OR+echocardiography%5Btiab%5D+OR+%22myocardial+fibrosis%22%5Btiab%5D%29+AND+%28%222026%2F08%2F28%22%5BDate+-+Publication%5D+%3A+%222026%2F10%2F20%22%5BDate+-+Publication%5D%29&retmode=json&retmax=9999",
      "count": 1,
      "ids": [
        "42873316"
      ],
      "query_translation": "(\"baxdrostat\"[Title/Abstract] OR \"lorundrostat\"[Title/Abstract] OR \"dexfadrostat\"[Title/Abstract] OR \"vicadrostat\"[Title/Abstract] OR \"aldosterone synthase inhibitor\"[Title/Abstract]) AND (\"left ventricular\"[Title/Abstract] OR \"LVH\"[Title/Abstract] OR \"remodeling\"[Title/Abstract] OR \"remodelling\"[Title/Abstract] OR \"CMR\"[Title/Abstract] OR \"echocardiography\"[Title/Abstract] OR \"myocardial fibrosis\"[Title/Abstract]) AND 2026/08/28:2026/10/20[Date - Publication]"
    },
    {
      "topic": "connectivity-test-only",
      "query": "hypertensive heart disease",
      "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=hypertensive+heart+disease&retmode=json&retmax=9999",
      "count": 163885,
      "ids": [
        "42897073",
        "42896784",
        "42896765",
        "42896184",
        "42896149",
        "42895730",
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        "42895024",
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        "42894232",
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        "42893808",
        "42893702",
        "42893460",
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        "42893359",
        "42893061",
        "42892957",
        "42892625",
        "42892583",
        "42892360",
        "42891961",
        "42891680",
        "42891596",
        "42891498",
        "42891485",
        "42891432",
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        "42890522",
        "42889325",
        "42889217",
        "42889095",
        "42888886",
        "42888612",
        "42887569",
        "42886846",
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        "42886603",
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        "42886083",
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        "42885566",
        "42885348",
        "42884729",
        "42884125",
        "42883770",
        "42883319",
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        "42882413",
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        "42882261",
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        "42882171",
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        "42879348",
        "42879346",
        "42878893",
        "42878712",
        "42878249",
        "42878095",
        "42877973",
        "42877906",
        "42877693",
        "42877094",
        "42876489",
        "42876376",
        "42876246",
        "42876020",
        "42875917",
        "42875145",
        "42874756",
        "42874670",
        "42874074",
        "42874048",
        "42873920",
        "42873558",
        "42873237",
        "42873064",
        "42872749",
        "42872259",
        "42872129",
        "42871754",
        "42871596",
        "42871482",
        "42871454",
        "42871168",
        "42870599",
        "42870543",
        "42869817",
        "42869063",
        "42868578",
        "42867544",
        "42867362",
        "42866875",
        "42866566",
        "42866327",
        "42866057",
        "42865926",
        "42865871",
        "42865761",
        "42865467",
        "42865379",
        "42865211",
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      "returned_count": 658
    },
    {
      "topic": "diagnosis-biomarkers",
      "query": "(hypertension AND (\"cardiac magnetic resonance\" OR \"global longitudinal strain\" OR NT-proBNP OR \"cardiac troponin\" OR \"ECG-LVH\")) AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
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    {
      "topic": "secondary-modifiers",
      "query": "((\"primary aldosteronism\" OR \"resistant hypertension\" OR (hypertension AND \"sleep apnea\")) AND (cardiac OR cardiovascular OR heart OR trial)) AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
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      "returned_count": 185
    },
    {
      "topic": "burden-statistics",
      "query": "(\"hypertensive heart disease\" OR (hypertension AND (\"global burden\" OR \"population-based\" OR registry))) AND FIRST_PDATE:[2026-08-28 TO 2026-10-20]",
      "endpoint": "https://www.ebi.ac.uk/europepmc/webservices/rest/search",
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    {
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      "endpoint": "https://www.ebi.ac.uk/europepmc/webservices/rest/search",
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      "key": "ish-news",
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    {
      "key": "jacc-resistant",
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      "bytes": 269418
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      "identity_check": "Rejected: path returned an unrelated pulse-pressure/cognition review. No claim extracted. Correct guideline later retrieved through its DOI and title verified."
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    },
    {
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      "status": 200,
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    "craft_text_search": {
      "query": "CRAFT blood pressure",
      "url": "https://trialsearch.who.int/?q=CRAFT%20blood%20pressure",
      "result": "No results for this query; not an absence of CRAFT worldwide."
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    "identifier_queries": [
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        "query": "NCT04347330",
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        "status": 200,
        "no_results_text": true
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      {
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        "query": "NCT04111419",
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        "status": 200,
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      "who_target": 1000,
      "interpretation": "Still stale relative to the existing published-cohort entry; no inference of a new recruitment change."
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    "site.ish-world.com 2026 hypertension October guideline",
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    "site.ish-world.com \"New ISH Global Practice Guidelines\" 2026",
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      "finding": "Campaign dates and inactive 2026 locator verified from the retrieved page; no participation figures inferred."
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      "url": "https://www.who.int/publications/i/item/9789240115569",
      "finding": "Retrieved WHO hypertension report is dated 23 September 2025, outside requested window; no new numeric burden entry added."
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    {
      "url": "https://world-heart-federation.org/?hl=en-US",
      "finding": "2026 World Heart Report concerns congenital heart disease; World Heart Day material is broad CVD, not a new HHD-specific source; not added."
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    {
      "url": "https://www.acc.org/latest-in-cardiology/journal-scans/2026/10/05/20/22/acc-releases-new-guidance-for-managing-resistant-hypertension",
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      "updated_by": [],
      "crossref_title": [
        "2026 ISH guidelines for the management of hypertension in Africa: the International Society of Hypertension (ISH) African Regional Advisory Group and the Pan African Society of Cardiology (PASCAR)"
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      "decision": "No retraction or expression-of-concern signal in checked PubMed types/comments or Crossref updated-by."
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      "updated_by": [],
      "crossref_title": [
        "Left ventricular hypertrophy in hypertension: a systematic review and meta-analysis of echocardiographic studies published from 2011 to 2025"
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      "decision": "No retraction or expression-of-concern signal in checked PubMed types/comments or Crossref updated-by."
    },
    "42885348": {
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      "crossref_url": "https://api.crossref.org/works/10.1093%2Feurjpc%2Fzwag527",
      "updated_by": [],
      "crossref_title": [
        "Effect of Colchicine on Arterial Stiffness in Patients With Hypertension: The COlchicine HypERtENsion Trial (COHERENT)"
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      "updated_by": [],
      "crossref_title": [
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      "decision": "No retraction or expression-of-concern signal in checked PubMed types/comments or Crossref updated-by."
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  "fulltext_evidence": {
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      "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13474632/fullTextXML",
      "identity": "Title/DOI matched live PubMed record",
      "quote": "no statistically significant interaction between prediabetes and malignant LVH",
      "quote_locator": "Results: Risk of incident HF by prediabetes and malignant LVH",
      "numeric_locator": "Table 1 analytic population; Table 2 malignant LVH/prediabetes row, model 2: HR 3.55 (1.98–6.36); following Results paragraph: interaction P=0.67",
      "definitions_locator": "Methods: Assessment of malignant LVH; troponin I rather than REMODEL troponin T"
    },
    "42895254": {
      "url": "https://jogh.org/2026/jogh-16-04313/",
      "identity": "Title/DOI matched live PubMed record",
      "quote": "the cohort was predominantly of European ancestry",
      "quote_locator": "Discussion: limitations",
      "numeric_locator": "Table 2 PCP-HF C 0.727 (0.705, 0.747), PCP-HF+PRS C 0.787 (0.767, 0.807); Table 3 delta C 0.060 (0.040, 0.078)",
      "design_locator": "Methods statistical analyses: random 1:1 split; limitations: absent QRS duration, no systematic HF subtype differentiation"
    },
    "42865430": {
      "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13654846/fullTextXML",
      "identity": "Title/DOI matched live PubMed record",
      "quote": "did not establish phenotype-specific medication effects",
      "quote_locator": "Conclusion",
      "support_locator": "Results/Discussion: hypertensive-pulmonary cluster; no significant medication-by-cluster interactions; external medication estimates descriptive due to inadequate balance"
    },
    "42554264": {
      "url": "https://www.ovid.com/jnls/jhypertension/fulltext/10.1097/hjh.0000000000004411~2026-ish-guidelines-for-the-management-of-hypertension-in",
      "identity": "Title/primary DOI matched live PubMed record",
      "quote": "structured chain of supervision and referral",
      "quote_locator": "Management of hypertension in Africa",
      "support_locator": "Table 6: ECG under essential investigations; echocardiogram under specialized investigations according to risk, expertise, logistics and history"
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    "screening": "Scope filters followed by focused title/abstract review, then full-text reading for all substantive new paper claims. Many broad-query hits concern pulmonary/pregnancy hypertension, other organs, cases, animal studies or redundant reviews and were not added. No PMID-free Europe PMC candidate survived triage; no DOI-only citation added.",
    "cochrane": "15 topic-specific strategies returned two already-catalogued target protocols. A broader CDSR strategy returned five records: those two protocols and three dialysis/stroke-rehabilitation reviews screened outside HHD scope. The two target full texts contain planned Methods but no review results; neither supersedes the existing synthesis."
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          "title": "Prediabetes, Malignant Left Ventricular Hypertrophy, and Risk of Incident Heart Failure Among Hypertensive Adults.",
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