{ "condition": "hypertension", "date": "2026-10-26", "engine": "codex", "window": { "from": "2026-10-19", "to": "2026-10-26", "primary": "publication date", "supplement": "Entrez date" }, "pubmed": { "measurement": { "query": "(hypertension AND (measurement OR diagnosis OR ambulatory OR \"home blood pressure\" OR cuffless OR \"white coat\" OR masked OR nocturnal)) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 140, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"measurability\"[All Fields] OR \"measurable\"[All Fields] OR \"measurably\"[All Fields] OR \"measure s\"[All Fields] OR \"measureable\"[All Fields] OR \"measured\"[All Fields] OR \"measurement\"[All Fields] OR \"measurement s\"[All Fields] OR \"measurements\"[All Fields] OR \"measurer\"[All Fields] OR \"measurers\"[All Fields] OR \"measuring\"[All Fields] OR \"measurings\"[All Fields] OR \"measurment\"[All Fields] OR \"measurments\"[All Fields] OR \"weights and measures\"[MeSH Terms] OR (\"weights\"[All Fields] AND \"measures\"[All Fields]) OR \"weights and measures\"[All Fields] OR \"measure\"[All Fields] OR \"measures\"[All Fields] OR (\"diagnosable\"[All Fields] OR \"diagnosi\"[All Fields] OR \"diagnosis\"[MeSH Terms] OR \"diagnosis\"[All Fields] OR \"diagnose\"[All Fields] OR \"diagnosed\"[All Fields] OR \"diagnoses\"[All Fields] OR \"diagnosing\"[All Fields] OR \"diagnosis\"[MeSH Subheading]) OR (\"ambulatories\"[All Fields] OR \"ambulatory\"[All Fields]) OR \"home blood pressure\"[All Fields] OR \"cuffless\"[All Fields] OR \"white coat\"[All Fields] OR (\"mask s\"[All Fields] OR \"masked\"[All Fields] OR \"masking\"[All Fields] OR \"masks\"[MeSH Terms] OR \"masks\"[All Fields]) OR (\"nocturnal\"[All Fields] OR \"nocturnality\"[All Fields] OR \"nocturnally\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42928015", "42927966", "42927934", "42927925", "42927374", "42927240", "42927237", "42927090", "42926177", "42925888", "42925856", "42925423", "42925335", "42925278", "42924837", "42924731", "42923692", "42923492", "42923456", "42922447", "42921885", "42921844", "42921587", "42921540", "42921483", "42921382", "42921236", "42921214", "42920888", "42920788", "42920388", "42920346", "42920293", "42920267", "42919976", "42919849", "42918920", "42918456", "42914550", "42914529", "42914154", "42913899", "42913703", "42912953", "42912827", "42912760", "42912696", "42912472", "42912171", "42912072", "42911966", "42911818", "42911359", "42911124", "42910563", "42910319", "42910120", "42910036", "42909728", "42909506", "42908312", "42908309", "42908184", "42907726", "42907241", "42907222", "42907171", "42906920", "42906749", "42906649", "42906455", "42905790", "42905207", "42905051", "42904318", "42904315", "42904311", "42902777", "42902603", "42902551", "42902512", "42901555", "42901554", "42901553", "42901542", "42901488", "42901463", "42901459", "42901323", "42901132", "42900455", "42899427", "42899353", "42899245", "42898806", "42898559", "42897967", "42897399", "42897358", "42896919", "42896765", "42896184", "42896149", "42896046", "42895852", "42895730", "42895713", "42895584", "42895276", "42895254", "42895024", "42895023", "42894107", "42894029", "42885806", "42885794", "42885784", "42885783", "42885782", "42858041", "42858037", "42858016", "42858008", "42858007", "42857992", "42853222", "42816405", "42775432", "42742153", "42741845", "42695342", "42678068", "42674000", "42549920", "42496049", "42295972", "42161430", "42155048", "42048256", "41818817" ] }, "cochrane_measurement": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (measurement OR diagnosis OR ambulatory OR \"home blood pressure\" OR cuffless OR \"white coat\" OR masked OR nocturnal))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"measurability\"[All Fields] OR \"measurable\"[All Fields] OR \"measurably\"[All Fields] OR \"measure s\"[All Fields] OR \"measureable\"[All Fields] OR \"measured\"[All Fields] OR \"measurement\"[All Fields] OR \"measurement s\"[All Fields] OR \"measurements\"[All Fields] OR \"measurer\"[All Fields] OR \"measurers\"[All Fields] OR \"measuring\"[All Fields] OR \"measurings\"[All Fields] OR \"measurment\"[All Fields] OR \"measurments\"[All Fields] OR \"weights and measures\"[MeSH Terms] OR (\"weights\"[All Fields] AND \"measures\"[All Fields]) OR \"weights and measures\"[All Fields] OR \"measure\"[All Fields] OR \"measures\"[All Fields] OR (\"diagnosable\"[All Fields] OR \"diagnosi\"[All Fields] OR \"diagnosis\"[MeSH Terms] OR \"diagnosis\"[All Fields] OR \"diagnose\"[All Fields] OR \"diagnosed\"[All Fields] OR \"diagnoses\"[All Fields] OR \"diagnosing\"[All Fields] OR \"diagnosis\"[MeSH Subheading]) OR (\"ambulatories\"[All Fields] OR \"ambulatory\"[All Fields]) OR \"home blood pressure\"[All Fields] OR \"cuffless\"[All Fields] OR \"white coat\"[All Fields] OR (\"mask s\"[All Fields] OR \"masked\"[All Fields] OR \"masking\"[All Fields] OR \"masks\"[MeSH Terms] OR \"masks\"[All Fields]) OR (\"nocturnal\"[All Fields] OR \"nocturnality\"[All Fields] OR \"nocturnally\"[All Fields]))) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "epidemiology": { "query": "(hypertension AND (prevalence OR epidemiology OR burden OR registry OR \"NCD-RisC\" OR \"Global Burden\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 105, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields] OR (\"epidemiologies\"[All Fields] OR \"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"epidemiology\"[MeSH Terms] OR \"epidemiology s\"[All Fields]) OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR (\"registries\"[MeSH Terms] OR \"registries\"[All Fields] OR \"registry\"[All Fields] OR \"registry s\"[All Fields]) OR \"NCD-RisC\"[All Fields] OR \"Global Burden\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42927934", "42927564", "42927563", "42927561", "42927374", "42927240", "42927090", "42926914", "42926119", "42925888", "42925685", "42925423", "42925238", "42925171", "42925136", "42924845", "42924837", "42924830", "42924731", "42924162", "42923692", "42921844", "42921587", "42921540", "42921498", "42921236", "42921137", "42921126", "42920888", "42920346", "42918618", "42914959", "42914615", "42914550", "42914154", "42914110", "42913911", "42912827", "42912760", "42912409", "42912171", "42912072", "42911818", "42911359", "42910756", "42910563", "42910441", "42909793", "42909728", "42908309", "42907705", "42907691", "42907142", "42906952", "42906920", "42905977", "42905045", "42904850", "42904315", "42904311", "42903495", "42902915", "42901931", "42901576", "42901555", "42901488", "42901459", "42901331", "42901323", "42901321", "42901132", "42900851", "42899554", "42897716", "42897399", "42897358", "42897213", "42896799", "42896667", "42895730", "42895713", "42895584", "42895276", "42895254", "42895025", "42895024", "42894107", "42894028", "42885813", "42885806", "42885794", "42885784", "42858041", "42858037", "42858016", "42858007", "42857992", "42816405", "42775432", "42751780", "42741845", "42678068", "42549920", "42161430", "42048256" ] }, "cochrane_epidemiology": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (prevalence OR epidemiology OR burden OR registry OR \"NCD-RisC\" OR \"Global Burden\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields] OR (\"epidemiologies\"[All Fields] OR \"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"epidemiology\"[MeSH Terms] OR \"epidemiology s\"[All Fields]) OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR (\"registries\"[MeSH Terms] OR \"registries\"[All Fields] OR \"registry\"[All Fields] OR \"registry s\"[All Fields]) OR \"NCD-RisC\"[All Fields] OR \"Global Burden\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "pathophysiology": { "query": "(hypertension AND (pathophysiology OR sympathetic OR inflammation OR microbiome OR natriuresis OR \"tissue sodium\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 52, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"pathophysiologies\"[All Fields] OR \"physiopathology\"[MeSH Subheading] OR \"physiopathology\"[All Fields] OR \"pathophysiology\"[All Fields] OR (\"sympathetic\"[All Fields] OR \"sympathetically\"[All Fields] OR \"sympathetics\"[All Fields]) OR (\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation s\"[All Fields]) OR (\"microbiome s\"[All Fields] OR \"microbiomic\"[All Fields] OR \"microbiomics\"[All Fields] OR \"microbiota\"[MeSH Terms] OR \"microbiota\"[All Fields] OR \"microbiome\"[All Fields] OR \"microbiomes\"[All Fields]) OR (\"natriuresis\"[MeSH Terms] OR \"natriuresis\"[All Fields] OR \"natriureses\"[All Fields]) OR \"tissue sodium\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42925958", "42925888", "42925726", "42925657", "42925445", "42925373", "42925335", "42924874", "42922447", "42921587", "42921214", "42919976", "42919643", "42919100", "42918456", "42918416", "42914558", "42913899", "42913173", "42912760", "42911548", "42911359", "42911124", "42910563", "42909451", "42909430", "42906920", "42906649", "42906130", "42905429", "42902603", "42902551", "42901975", "42901576", "42901331", "42901323", "42895584", "42885806", "42885794", "42885783", "42885782", "42858041", "42858037", "42858016", "42858008", "42751780", "42742153", "42695342", "42678068", "42549920", "42295972", "42161430" ] }, "cochrane_pathophysiology": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (pathophysiology OR sympathetic OR inflammation OR microbiome OR natriuresis OR \"tissue sodium\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"pathophysiologies\"[All Fields] OR \"physiopathology\"[MeSH Subheading] OR \"physiopathology\"[All Fields] OR \"pathophysiology\"[All Fields] OR (\"sympathetic\"[All Fields] OR \"sympathetically\"[All Fields] OR \"sympathetics\"[All Fields]) OR (\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation s\"[All Fields]) OR (\"microbiome s\"[All Fields] OR \"microbiomic\"[All Fields] OR \"microbiomics\"[All Fields] OR \"microbiota\"[MeSH Terms] OR \"microbiota\"[All Fields] OR \"microbiome\"[All Fields] OR \"microbiomes\"[All Fields]) OR (\"natriuresis\"[MeSH Terms] OR \"natriuresis\"[All Fields] OR \"natriureses\"[All Fields]) OR \"tissue sodium\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "genetics": { "query": "(hypertension AND (genetic OR GWAS OR polygenic OR monogenic OR Liddle)) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 30, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"genetic\"[All Fields] OR \"genetical\"[All Fields] OR \"genetically\"[All Fields] OR \"genetics\"[MeSH Subheading] OR \"genetics\"[All Fields] OR \"genetics\"[MeSH Terms] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields]) OR (\"polygene\"[All Fields] OR \"polygenes\"[All Fields] OR \"polygenic\"[All Fields] OR \"polygenically\"[All Fields] OR \"polygenicity\"[All Fields]) OR (\"monogenic\"[All Fields] OR \"monogenically\"[All Fields] OR \"monogenics\"[All Fields]) OR (\"liddle\"[All Fields] OR \"liddle s\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42927780", "42925726", "42925373", "42924838", "42924830", "42922444", "42921483", "42919435", "42913823", "42913173", "42912696", "42912472", "42911168", "42909728", "42908770", "42907241", "42905856", "42905688", "42905207", "42901931", "42901463", "42901331", "42896815", "42896046", "42895254", "42858016", "42779507", "42741845", "42695342", "42360857" ] }, "cochrane_genetics": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (genetic OR GWAS OR polygenic OR monogenic OR Liddle))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"genetic\"[All Fields] OR \"genetical\"[All Fields] OR \"genetically\"[All Fields] OR \"genetics\"[MeSH Subheading] OR \"genetics\"[All Fields] OR \"genetics\"[MeSH Terms] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields]) OR (\"polygene\"[All Fields] OR \"polygenes\"[All Fields] OR \"polygenic\"[All Fields] OR \"polygenically\"[All Fields] OR \"polygenicity\"[All Fields]) OR (\"monogenic\"[All Fields] OR \"monogenically\"[All Fields] OR \"monogenics\"[All Fields]) OR (\"liddle\"[All Fields] OR \"liddle s\"[All Fields]))) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "secondary": { "query": "(hypertension AND (secondary OR aldosteronism OR renovascular OR phaeochromocytoma OR pheochromocytoma OR \"sleep apnea\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 51, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"neoplasm metastasis\"[MeSH Terms] OR (\"neoplasm\"[All Fields] AND \"metastasis\"[All Fields]) OR \"neoplasm metastasis\"[All Fields] OR \"secondaries\"[All Fields] OR \"secondary\"[MeSH Subheading] OR \"secondary\"[All Fields] OR (\"aldosteron\"[All Fields] OR \"aldosterone\"[Supplementary Concept] OR \"aldosterone\"[All Fields] OR \"aldosterone\"[MeSH Terms] OR \"aldosterone s\"[All Fields] OR \"aldosterones\"[All Fields] OR \"hyperaldosteronism\"[MeSH Terms] OR \"hyperaldosteronism\"[All Fields] OR \"aldosteronism\"[All Fields]) OR \"renovascular\"[All Fields] OR (\"phaeochromocytoma\"[All Fields] OR \"pheochromocytoma\"[MeSH Terms] OR \"pheochromocytoma\"[All Fields] OR \"phaeochromocytomas\"[All Fields] OR \"pheochromocytomas\"[All Fields]) OR (\"phaeochromocytoma\"[All Fields] OR \"pheochromocytoma\"[MeSH Terms] OR \"pheochromocytoma\"[All Fields] OR \"phaeochromocytomas\"[All Fields] OR \"pheochromocytomas\"[All Fields]) OR \"sleep apnea\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42927237", "42927090", "42926177", "42925958", "42925856", "42924731", "42924171", "42923692", "42923492", "42921540", "42921214", "42920788", "42920414", "42920346", "42920080", "42919849", "42919100", "42914959", "42914775", "42914550", "42914154", "42912953", "42912472", "42911181", "42911168", "42910900", "42910547", "42909728", "42909506", "42908184", "42907726", "42907691", "42906749", "42905977", "42905688", "42902777", "42902709", "42902603", "42901554", "42901323", "42901321", "42901132", "42897997", "42897716", "42897033", "42896815", "42895584", "42894960", "42885783", "42858008", "42155048" ] }, "cochrane_secondary": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (secondary OR aldosteronism OR renovascular OR phaeochromocytoma OR pheochromocytoma OR \"sleep apnea\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"neoplasm metastasis\"[MeSH Terms] OR (\"neoplasm\"[All Fields] AND \"metastasis\"[All Fields]) OR \"neoplasm metastasis\"[All Fields] OR \"secondaries\"[All Fields] OR \"secondary\"[MeSH Subheading] OR \"secondary\"[All Fields] OR (\"aldosteron\"[All Fields] OR \"aldosterone\"[Supplementary Concept] OR \"aldosterone\"[All Fields] OR \"aldosterone\"[MeSH Terms] OR \"aldosterone s\"[All Fields] OR \"aldosterones\"[All Fields] OR \"hyperaldosteronism\"[MeSH Terms] OR \"hyperaldosteronism\"[All Fields] OR \"aldosteronism\"[All Fields]) OR \"renovascular\"[All Fields] OR (\"phaeochromocytoma\"[All Fields] OR \"pheochromocytoma\"[MeSH Terms] OR \"pheochromocytoma\"[All Fields] OR \"phaeochromocytomas\"[All Fields] OR \"pheochromocytomas\"[All Fields]) OR (\"phaeochromocytoma\"[All Fields] OR \"pheochromocytoma\"[MeSH Terms] OR \"pheochromocytoma\"[All Fields] OR \"phaeochromocytomas\"[All Fields] OR \"pheochromocytomas\"[All Fields]) OR \"sleep apnea\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "risk_outcomes": { "query": "(hypertension AND (\"cardiovascular risk\" OR mortality OR \"J curve\" OR \"blood pressure variability\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 59, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"cardiovascular risk\"[All Fields] OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading]) OR \"J curve\"[All Fields] OR \"blood pressure variability\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42927786", "42927564", "42927561", "42925956", "42925888", "42925423", "42924845", "42924838", "42924171", "42924162", "42924047", "42921844", "42921498", "42921137", "42920888", "42919976", "42919435", "42912953", "42912760", "42912409", "42911657", "42911548", "42909728", "42909506", "42907726", "42907705", "42906455", "42905688", "42902915", "42902603", "42902551", "42901731", "42901553", "42901331", "42901323", "42901321", "42900524", "42899353", "42899341", "42897716", "42897033", "42896765", "42896667", "42896184", "42895584", "42894028", "42893827", "42885813", "42885806", "42860817", "42858041", "42858037", "42858007", "42816405", "42751780", "42741845", "42678068", "42048256", "41850709" ] }, "cochrane_risk_outcomes": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (\"cardiovascular risk\" OR mortality OR \"J curve\" OR \"blood pressure variability\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"cardiovascular risk\"[All Fields] OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading]) OR \"J curve\"[All Fields] OR \"blood pressure variability\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "targets": { "query": "(hypertension AND (\"blood pressure target\" OR \"blood pressure targets\" OR \"intensive treatment\" OR \"intensive blood pressure\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 3, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"blood pressure target\"[All Fields] OR \"blood pressure targets\"[All Fields] OR \"intensive treatment\"[All Fields] OR \"intensive blood pressure\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42926177", "42921718", "42905643" ] }, "cochrane_targets": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (\"blood pressure target\" OR \"blood pressure targets\" OR \"intensive treatment\" OR \"intensive blood pressure\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"blood pressure target\"[All Fields] OR \"blood pressure targets\"[All Fields] OR \"intensive treatment\"[All Fields] OR \"intensive blood pressure\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "lifestyle": { "query": "(hypertension AND (sodium OR potassium OR \"salt substitute\" OR DASH OR exercise OR lifestyle OR alcohol OR \"weight loss\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 51, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"sodium\"[Supplementary Concept] OR \"sodium\"[All Fields] OR \"sodium\"[MeSH Terms] OR \"sodiums\"[All Fields] OR (\"potassium dietary\"[Supplementary Concept] OR \"potassium dietary\"[All Fields] OR \"potassium\"[All Fields] OR \"potassium\"[Supplementary Concept] OR \"potassium, dietary\"[MeSH Terms] OR (\"potassium\"[All Fields] AND \"dietary\"[All Fields]) OR \"dietary potassium\"[All Fields] OR \"potassium\"[MeSH Terms]) OR \"salt substitute\"[All Fields] OR \"DASH\"[All Fields] OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]) OR (\"life style\"[MeSH Terms] OR (\"life\"[All Fields] AND \"style\"[All Fields]) OR \"life style\"[All Fields] OR \"lifestyle\"[All Fields] OR \"lifestyles\"[All Fields]) OR (\"alcohol s\"[All Fields] OR \"alcoholate\"[All Fields] OR \"alcoholates\"[All Fields] OR \"alcohols\"[Supplementary Concept] OR \"alcohols\"[All Fields] OR \"alcohols\"[MeSH Terms] OR \"ethanol\"[Supplementary Concept] OR \"ethanol\"[All Fields] OR \"alcohol\"[All Fields] OR \"ethanol\"[MeSH Terms]) OR \"weight loss\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42927966", "42927902", "42927090", "42926177", "42925973", "42925956", "42925888", "42925445", "42924874", "42923086", "42921885", "42921683", "42921009", "42920080", "42919117", "42918456", "42912472", "42912409", "42911657", "42911124", "42911078", "42910756", "42910563", "42909506", "42908309", "42906952", "42906579", "42905688", "42905359", "42904850", "42901975", "42901931", "42901554", "42900851", "42899427", "42899341", "42897358", "42897042", "42896149", "42895852", "42895024", "42885794", "42885782", "42858008", "42751780", "42741845", "42695342", "42678068", "42674000", "42496049", "41786365" ] }, "cochrane_lifestyle": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (sodium OR potassium OR \"salt substitute\" OR DASH OR exercise OR lifestyle OR alcohol OR \"weight loss\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"sodium\"[Supplementary Concept] OR \"sodium\"[All Fields] OR \"sodium\"[MeSH Terms] OR \"sodiums\"[All Fields] OR (\"potassium dietary\"[Supplementary Concept] OR \"potassium dietary\"[All Fields] OR \"potassium\"[All Fields] OR \"potassium\"[Supplementary Concept] OR \"potassium, dietary\"[MeSH Terms] OR (\"potassium\"[All Fields] AND \"dietary\"[All Fields]) OR \"dietary potassium\"[All Fields] OR \"potassium\"[MeSH Terms]) OR \"salt substitute\"[All Fields] OR \"DASH\"[All Fields] OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]) OR (\"life style\"[MeSH Terms] OR (\"life\"[All Fields] AND \"style\"[All Fields]) OR \"life style\"[All Fields] OR \"lifestyle\"[All Fields] OR \"lifestyles\"[All Fields]) OR (\"alcohol s\"[All Fields] OR \"alcoholate\"[All Fields] OR \"alcoholates\"[All Fields] OR \"alcohols\"[Supplementary Concept] OR \"alcohols\"[All Fields] OR \"alcohols\"[MeSH Terms] OR \"ethanol\"[Supplementary Concept] OR \"ethanol\"[All Fields] OR \"alcohol\"[All Fields] OR \"ethanol\"[MeSH Terms]) OR \"weight loss\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "pharmacotherapy": { "query": "(hypertension AND (antihypertensive OR baxdrostat OR lorundrostat OR zilebesiran OR aprocitentan OR \"single pill\" OR chronotherapy)) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 15, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"antihypertension\"[All Fields] OR \"antihypertensive agents\"[Pharmacological Action] OR \"antihypertensive agents\"[Supplementary Concept] OR \"antihypertensive agents\"[All Fields] OR \"antihypertensive\"[All Fields] OR \"antihypertensive agents\"[MeSH Terms] OR (\"antihypertensive\"[All Fields] AND \"agents\"[All Fields]) OR \"antihypertensives\"[All Fields] OR (\"baxdrostat\"[Supplementary Concept] OR \"baxdrostat\"[All Fields]) OR \"lorundrostat\"[All Fields] OR \"zilebesiran\"[All Fields] OR (\"aprocitentan\"[Supplementary Concept] OR \"aprocitentan\"[All Fields]) OR \"single pill\"[All Fields] OR (\"chronotherapy\"[MeSH Terms] OR \"chronotherapy\"[All Fields] OR \"chronotherapies\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42926914", "42925335", "42921718", "42919849", "42919100", "42914747", "42907726", "42905977", "42905793", "42902777", "42895024", "42894028", "42885806", "42858041", "42695342" ] }, "cochrane_pharmacotherapy": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (antihypertensive OR baxdrostat OR lorundrostat OR zilebesiran OR aprocitentan OR \"single pill\" OR chronotherapy))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"antihypertension\"[All Fields] OR \"antihypertensive agents\"[Pharmacological Action] OR \"antihypertensive agents\"[Supplementary Concept] OR \"antihypertensive agents\"[All Fields] OR \"antihypertensive\"[All Fields] OR \"antihypertensive agents\"[MeSH Terms] OR (\"antihypertensive\"[All Fields] AND \"agents\"[All Fields]) OR \"antihypertensives\"[All Fields] OR (\"baxdrostat\"[Supplementary Concept] OR \"baxdrostat\"[All Fields]) OR \"lorundrostat\"[All Fields] OR \"zilebesiran\"[All Fields] OR (\"aprocitentan\"[Supplementary Concept] OR \"aprocitentan\"[All Fields]) OR \"single pill\"[All Fields] OR (\"chronotherapy\"[MeSH Terms] OR \"chronotherapy\"[All Fields] OR \"chronotherapies\"[All Fields]))) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "resistant": { "query": "(\"resistant hypertension\" OR \"refractory hypertension\") AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 6, "translation": "(\"resistant hypertension\"[All Fields] OR \"refractory hypertension\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42926234", "42921666", "42919100", "42914747", "42912385", "42907726" ] }, "cochrane_resistant": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (\"resistant hypertension\" OR \"refractory hypertension\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"resistant hypertension\"[All Fields] OR \"refractory hypertension\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "devices": { "query": "(hypertension AND (\"renal denervation\" OR \"baroreflex activation\" OR \"renal nerve\" OR \"interventional therapy\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 4, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"renal denervation\"[All Fields] OR \"baroreflex activation\"[All Fields] OR \"renal nerve\"[All Fields] OR \"interventional therapy\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42919100", "42905791", "42902709", "42901554" ] }, "cochrane_devices": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (\"renal denervation\" OR \"baroreflex activation\" OR \"renal nerve\" OR \"interventional therapy\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"renal denervation\"[All Fields] OR \"baroreflex activation\"[All Fields] OR \"renal nerve\"[All Fields] OR \"interventional therapy\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "pregnancy": { "query": "(hypertension AND (pregnancy OR postpartum OR preeclampsia OR \"pre-eclampsia\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 23, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"pregnancy\"[MeSH Terms] OR \"pregnancy\"[All Fields] OR \"pregnancies\"[All Fields] OR \"pregnancy s\"[All Fields] OR (\"postpartum period\"[MeSH Terms] OR (\"postpartum\"[All Fields] AND \"period\"[All Fields]) OR \"postpartum period\"[All Fields] OR \"postpartum\"[All Fields]) OR (\"pre-eclampsia\"[MeSH Terms] OR \"pre-eclampsia\"[All Fields] OR \"preeclampsia\"[All Fields]) OR \"pre-eclampsia\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42927240", "42927237", "42925856", "42924837", "42921498", "42921483", "42920788", "42919435", "42914615", "42914558", "42914154", "42913173", "42912072", "42911548", "42908312", "42905051", "42901463", "42895025", "42893827", "42751780", "42678068", "42583861", "42155048" ] }, "cochrane_pregnancy": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (pregnancy OR postpartum OR preeclampsia OR \"pre-eclampsia\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"pregnancy\"[MeSH Terms] OR \"pregnancy\"[All Fields] OR \"pregnancies\"[All Fields] OR \"pregnancy s\"[All Fields] OR (\"postpartum period\"[MeSH Terms] OR (\"postpartum\"[All Fields] AND \"period\"[All Fields]) OR \"postpartum period\"[All Fields] OR \"postpartum\"[All Fields]) OR (\"pre-eclampsia\"[MeSH Terms] OR \"pre-eclampsia\"[All Fields] OR \"preeclampsia\"[All Fields]) OR \"pre-eclampsia\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "special_populations": { "query": "(hypertension AND (\"chronic kidney disease\" OR diabetes OR frailty OR frail OR deprescribing OR pediatric OR paediatric OR ethnicity OR HIV)) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 138, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"chronic kidney disease\"[All Fields] OR (\"diabete\"[All Fields] OR \"diabetes mellitus\"[MeSH Terms] OR (\"diabetes\"[All Fields] AND \"mellitus\"[All Fields]) OR \"diabetes mellitus\"[All Fields] OR \"diabetes\"[All Fields] OR \"diabetes insipidus\"[MeSH Terms] OR (\"diabetes\"[All Fields] AND \"insipidus\"[All Fields]) OR \"diabetes insipidus\"[All Fields] OR \"diabetic\"[All Fields] OR \"diabetics\"[All Fields] OR \"diabets\"[All Fields]) OR (\"frailty\"[MeSH Terms] OR \"frailty\"[All Fields] OR \"frailties\"[All Fields]) OR (\"frail\"[All Fields] OR \"frails\"[All Fields] OR \"frailty\"[MeSH Terms] OR \"frailty\"[All Fields] OR \"frailness\"[All Fields]) OR (\"deprescribe\"[All Fields] OR \"deprescribed\"[All Fields] OR \"deprescriptions\"[MeSH Terms] OR \"deprescriptions\"[All Fields] OR \"deprescribing\"[All Fields]) OR (\"paediatrics\"[All Fields] OR \"pediatrics\"[MeSH Terms] OR \"pediatrics\"[All Fields] OR \"paediatric\"[All Fields] OR \"pediatric\"[All Fields]) OR (\"paediatrics\"[All Fields] OR \"pediatrics\"[MeSH Terms] OR \"pediatrics\"[All Fields] OR \"paediatric\"[All Fields] OR \"pediatric\"[All Fields]) OR (\"ethnic\"[All Fields] OR \"ethnical\"[All Fields] OR \"ethnically\"[All Fields] OR \"ethnicities\"[All Fields] OR \"ethnics\"[All Fields] OR \"ethnology\"[MeSH Subheading] OR \"ethnology\"[All Fields] OR \"ethnicity\"[All Fields] OR \"ethnology\"[MeSH Terms] OR \"ethnicity\"[MeSH Terms]) OR (\"hiv\"[MeSH Terms] OR \"hiv\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42927966", "42927934", "42927780", "42927564", "42927561", "42927374", "42927237", "42927090", "42926914", "42926177", "42926119", "42925973", "42925956", "42925888", "42925657", "42925373", "42925238", "42924845", "42924838", "42924837", "42924522", "42924047", "42923785", "42923692", "42923086", "42922442", "42921844", "42921666", "42921587", "42921540", "42921214", "42921137", "42920960", "42920888", "42920788", "42920293", "42920267", "42920080", "42919645", "42919100", "42918618", "42918456", "42918416", "42914747", "42914615", "42914154", "42914110", "42913773", "42912827", "42912716", "42912472", "42911818", "42911078", "42910756", "42910511", "42910441", "42909613", "42909506", "42909187", "42908312", "42908184", "42907726", "42907705", "42907222", "42907142", "42906952", "42906920", "42906855", "42906749", "42906579", "42906455", "42905791", "42905688", "42905429", "42905359", "42905242", "42905045", "42904850", "42904318", "42904315", "42904311", "42902512", "42901975", "42901731", "42901576", "42901555", "42901554", "42901553", "42901542", "42901488", "42901463", "42901459", "42901323", "42901132", "42900851", "42899554", "42899427", "42899353", "42897967", "42897033", "42896784", "42896765", "42896667", "42896184", "42896149", "42896046", "42895935", "42895852", "42895796", "42895730", "42895276", "42895259", "42895078", "42895025", "42894960", "42894107", "42894029", "42893827", "42885813", "42885784", "42885782", "42860817", "42858041", "42858037", "42858016", "42858007", "42751780", "42742153", "42741845", "42709004", "42695342", "42678068", "42610223", "42549920", "42496049", "42155048", "42048256", "41850709" ] }, "cochrane_special_populations": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (\"chronic kidney disease\" OR diabetes OR frailty OR frail OR deprescribing OR pediatric OR paediatric OR ethnicity OR HIV))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"chronic kidney disease\"[All Fields] OR (\"diabete\"[All Fields] OR \"diabetes mellitus\"[MeSH Terms] OR (\"diabetes\"[All Fields] AND \"mellitus\"[All Fields]) OR \"diabetes mellitus\"[All Fields] OR \"diabetes\"[All Fields] OR \"diabetes insipidus\"[MeSH Terms] OR (\"diabetes\"[All Fields] AND \"insipidus\"[All Fields]) OR \"diabetes insipidus\"[All Fields] OR \"diabetic\"[All Fields] OR \"diabetics\"[All Fields] OR \"diabets\"[All Fields]) OR (\"frailty\"[MeSH Terms] OR \"frailty\"[All Fields] OR \"frailties\"[All Fields]) OR (\"frail\"[All Fields] OR \"frails\"[All Fields] OR \"frailty\"[MeSH Terms] OR \"frailty\"[All Fields] OR \"frailness\"[All Fields]) OR (\"deprescribe\"[All Fields] OR \"deprescribed\"[All Fields] OR \"deprescriptions\"[MeSH Terms] OR \"deprescriptions\"[All Fields] OR \"deprescribing\"[All Fields]) OR (\"paediatrics\"[All Fields] OR \"pediatrics\"[MeSH Terms] OR \"pediatrics\"[All Fields] OR \"paediatric\"[All Fields] OR \"pediatric\"[All Fields]) OR (\"paediatrics\"[All Fields] OR \"pediatrics\"[MeSH Terms] OR \"pediatrics\"[All Fields] OR \"paediatric\"[All Fields] OR \"pediatric\"[All Fields]) OR (\"ethnic\"[All Fields] OR \"ethnical\"[All Fields] OR \"ethnically\"[All Fields] OR \"ethnicities\"[All Fields] OR \"ethnics\"[All Fields] OR \"ethnology\"[MeSH Subheading] OR \"ethnology\"[All Fields] OR \"ethnicity\"[All Fields] OR \"ethnology\"[MeSH Terms] OR \"ethnicity\"[MeSH Terms]) OR (\"hiv\"[MeSH Terms] OR \"hiv\"[All Fields]))) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "implementation": { "query": "(hypertension AND (adherence OR implementation OR \"community health\" OR telehealth OR \"digital health\" OR \"primary care\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 49, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"adherance\"[All Fields] OR \"adhere\"[All Fields] OR \"adhered\"[All Fields] OR \"adherence\"[All Fields] OR \"adherences\"[All Fields] OR \"adherent\"[All Fields] OR \"adherents\"[All Fields] OR \"adherer\"[All Fields] OR \"adherers\"[All Fields] OR \"adheres\"[All Fields] OR \"adhering\"[All Fields] OR (\"implementability\"[All Fields] OR \"implementable\"[All Fields] OR \"implementation\"[All Fields] OR \"implementation s\"[All Fields] OR \"implementational\"[All Fields] OR \"implementations\"[All Fields] OR \"implementer\"[All Fields] OR \"implementers\"[All Fields] OR \"implemention\"[All Fields]) OR \"community health\"[All Fields] OR (\"telehealth s\"[All Fields] OR \"telemedicine\"[MeSH Terms] OR \"telemedicine\"[All Fields] OR \"telehealth\"[All Fields]) OR \"digital health\"[All Fields] OR \"primary care\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42927564", "42927090", "42926914", "42925956", "42925685", "42925423", "42924845", "42924837", "42924731", "42923492", "42921587", "42921498", "42921137", "42921009", "42920888", "42920388", "42919582", "42919117", "42918618", "42918456", "42914550", "42914169", "42914167", "42914154", "42914110", "42912953", "42912686", "42912409", "42911359", "42910116", "42909506", "42907726", "42907705", "42907691", "42907142", "42905051", "42901767", "42899353", "42897213", "42897042", "42897033", "42896149", "42885806", "42860817", "42858037", "42741845", "42678068", "41850709", "41786365" ] }, "cochrane_implementation": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (adherence OR implementation OR \"community health\" OR telehealth OR \"digital health\" OR \"primary care\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"adherance\"[All Fields] OR \"adhere\"[All Fields] OR \"adhered\"[All Fields] OR \"adherence\"[All Fields] OR \"adherences\"[All Fields] OR \"adherent\"[All Fields] OR \"adherents\"[All Fields] OR \"adherer\"[All Fields] OR \"adherers\"[All Fields] OR \"adheres\"[All Fields] OR \"adhering\"[All Fields] OR (\"implementability\"[All Fields] OR \"implementable\"[All Fields] OR \"implementation\"[All Fields] OR \"implementation s\"[All Fields] OR \"implementational\"[All Fields] OR \"implementations\"[All Fields] OR \"implementer\"[All Fields] OR \"implementers\"[All Fields] OR \"implemention\"[All Fields]) OR \"community health\"[All Fields] OR (\"telehealth s\"[All Fields] OR \"telemedicine\"[MeSH Terms] OR \"telemedicine\"[All Fields] OR \"telehealth\"[All Fields]) OR \"digital health\"[All Fields] OR \"primary care\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "emergencies": { "query": "(hypertension AND (emergency OR emergencies OR inpatient OR \"asymptomatic elevated\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 37, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"emerge\"[All Fields] OR \"emerged\"[All Fields] OR \"emergence\"[All Fields] OR \"emergences\"[All Fields] OR \"emergencies\"[MeSH Terms] OR \"emergencies\"[All Fields] OR \"emergency\"[All Fields] OR \"emergent\"[All Fields] OR \"emergently\"[All Fields] OR \"emergents\"[All Fields] OR \"emerges\"[All Fields] OR \"emerging\"[All Fields] OR (\"emerge\"[All Fields] OR \"emerged\"[All Fields] OR \"emergence\"[All Fields] OR \"emergences\"[All Fields] OR \"emergencies\"[MeSH Terms] OR \"emergencies\"[All Fields] OR \"emergency\"[All Fields] OR \"emergent\"[All Fields] OR \"emergently\"[All Fields] OR \"emergents\"[All Fields] OR \"emerges\"[All Fields] OR \"emerging\"[All Fields]) OR (\"inpatient s\"[All Fields] OR \"inpatients\"[MeSH Terms] OR \"inpatients\"[All Fields] OR \"inpatient\"[All Fields]) OR \"asymptomatic elevated\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42928015", "42927810", "42925888", "42925685", "42922444", "42921540", "42921498", "42920414", "42920388", "42920080", "42918456", "42914550", "42913773", "42912827", "42911359", "42907726", "42907241", "42906749", "42906649", "42906455", "42906130", "42905051", "42902551", "42901931", "42901576", "42901331", "42900313", "42899245", "42897042", "42897033", "42895713", "42895023", "42885794", "42885783", "42860817", "42775432", "41786365" ] }, "cochrane_emergencies": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (emergency OR emergencies OR inpatient OR \"asymptomatic elevated\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"emerge\"[All Fields] OR \"emerged\"[All Fields] OR \"emergence\"[All Fields] OR \"emergences\"[All Fields] OR \"emergencies\"[MeSH Terms] OR \"emergencies\"[All Fields] OR \"emergency\"[All Fields] OR \"emergent\"[All Fields] OR \"emergently\"[All Fields] OR \"emergents\"[All Fields] OR \"emerges\"[All Fields] OR \"emerging\"[All Fields] OR (\"emerge\"[All Fields] OR \"emerged\"[All Fields] OR \"emergence\"[All Fields] OR \"emergences\"[All Fields] OR \"emergencies\"[MeSH Terms] OR \"emergencies\"[All Fields] OR \"emergency\"[All Fields] OR \"emergent\"[All Fields] OR \"emergently\"[All Fields] OR \"emergents\"[All Fields] OR \"emerges\"[All Fields] OR \"emerging\"[All Fields]) OR (\"inpatient s\"[All Fields] OR \"inpatients\"[MeSH Terms] OR \"inpatients\"[All Fields] OR \"inpatient\"[All Fields]) OR \"asymptomatic elevated\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "guidelines": { "query": "(hypertension AND (guideline OR consensus OR \"position paper\" OR recommendations)) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 25, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"guideline\"[Publication Type] OR \"guidelines as topic\"[MeSH Terms] OR \"guideline\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR \"position paper\"[All Fields] OR (\"recommend\"[All Fields] OR \"recommendable\"[All Fields] OR \"recommendation\"[All Fields] OR \"recommendation s\"[All Fields] OR \"recommendations\"[All Fields] OR \"recommended\"[All Fields] OR \"recommending\"[All Fields] OR \"recommends\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42926914", "42926177", "42925856", "42924047", "42921718", "42921126", "42920888", "42914110", "42913703", "42911168", "42910756", "42909506", "42907705", "42906855", "42906749", "42905688", "42900851", "42899341", "42897399", "42897042", "42897033", "42895276", "42885806", "42858041", "42775432" ] }, "cochrane_guidelines": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (guideline OR consensus OR \"position paper\" OR recommendations))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"guideline\"[Publication Type] OR \"guidelines as topic\"[MeSH Terms] OR \"guideline\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR \"position paper\"[All Fields] OR (\"recommend\"[All Fields] OR \"recommendable\"[All Fields] OR \"recommendation\"[All Fields] OR \"recommendation s\"[All Fields] OR \"recommendations\"[All Fields] OR \"recommended\"[All Fields] OR \"recommending\"[All Fields] OR \"recommends\"[All Fields]))) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "patient_experience": { "query": "(hypertension AND (qualitative OR \"patient experience\" OR \"patient reported\" OR advocacy OR \"treatment burden\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 7, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields] OR \"patient experience\"[All Fields] OR \"patient reported\"[All Fields] OR (\"advocacies\"[All Fields] OR \"advocacy\"[All Fields] OR \"advocacy s\"[All Fields]) OR \"treatment burden\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42925685", "42921683", "42914558", "42910441", "42907142", "42858037", "41786365" ] }, "cochrane_patient_experience": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (qualitative OR \"patient experience\" OR \"patient reported\" OR advocacy OR \"treatment burden\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields] OR \"patient experience\"[All Fields] OR \"patient reported\"[All Fields] OR (\"advocacies\"[All Fields] OR \"advocacy\"[All Fields] OR \"advocacy s\"[All Fields]) OR \"treatment burden\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "safety": { "query": "(hypertension AND (\"adverse effects\" OR hypotension OR hyperkalemia OR safety OR \"drug induced\")) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 51, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"adverse effects\"[All Fields] OR (\"antihypertensive agents\"[Pharmacological Action] OR \"antihypertensive agents\"[Supplementary Concept] OR \"antihypertensive agents\"[All Fields] OR \"hypotensives\"[All Fields] OR \"antihypertensive agents\"[MeSH Terms] OR (\"antihypertensive\"[All Fields] AND \"agents\"[All Fields]) OR \"hypotension\"[MeSH Terms] OR \"hypotension\"[All Fields] OR \"hypotensions\"[All Fields] OR \"hypotensive\"[All Fields]) OR (\"hyperkalaemia\"[All Fields] OR \"hyperkalemia\"[MeSH Terms] OR \"hyperkalemia\"[All Fields] OR \"hyperkalemias\"[All Fields]) OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]) OR \"drug induced\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42927966", "42927786", "42926177", "42925973", "42925856", "42924171", "42922442", "42921718", "42920888", "42920388", "42920346", "42920080", "42919117", "42918485", "42914959", "42914775", "42914747", "42914529", "42912696", "42911966", "42911714", "42911657", "42911181", "42910900", "42910366", "42909793", "42909451", "42908770", "42907726", "42907691", "42907142", "42906579", "42906130", "42905688", "42905242", "42905051", "42902777", "42902709", "42902603", "42902551", "42901555", "42896815", "42896784", "42895023", "42885806", "42858041", "42709004", "42695342", "42622591", "42161430", "41850709" ] }, "cochrane_safety": { "query": "(\"Cochrane Database Syst Rev\"[jour] AND (hypertension AND (\"adverse effects\" OR hypotension OR hyperkalemia OR safety OR \"drug induced\"))) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 0, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"adverse effects\"[All Fields] OR (\"antihypertensive agents\"[Pharmacological Action] OR \"antihypertensive agents\"[Supplementary Concept] OR \"antihypertensive agents\"[All Fields] OR \"hypotensives\"[All Fields] OR \"antihypertensive agents\"[MeSH Terms] OR (\"antihypertensive\"[All Fields] AND \"agents\"[All Fields]) OR \"hypotension\"[MeSH Terms] OR \"hypotension\"[All Fields] OR \"hypotensions\"[All Fields] OR \"hypotensive\"[All Fields]) OR (\"hyperkalaemia\"[All Fields] OR \"hyperkalemia\"[MeSH Terms] OR \"hyperkalemia\"[All Fields] OR \"hyperkalemias\"[All Fields]) OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]) OR \"drug induced\"[All Fields])) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [] }, "broad_title": { "query": "(hypertension[ti]) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 91, "translation": "\"hypertension\"[Title] AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42927925", "42927902", "42927786", "42927780", "42927003", "42926914", "42926234", "42926177", "42925958", "42925856", "42925726", "42925445", "42925423", "42925348", "42924848", "42924837", "42924731", "42924522", "42924171", "42924162", "42924047", "42922444", "42921844", "42921683", "42921666", "42921236", "42921009", "42920960", "42920346", "42919645", "42919582", "42919100", "42918485", "42914747", "42914514", "42914169", "42914167", "42913899", "42913275", "42912953", "42912827", "42912385", "42911818", "42911714", "42911657", "42911359", "42911186", "42911168", "42910788", "42910319", "42910036", "42909506", "42908309", "42908184", "42907705", "42907171", "42905977", "42905856", "42905643", "42905429", "42901767", "42901553", "42900495", "42900455", "42898806", "42898559", "42897997", "42897073", "42897052", "42896799", "42896194", "42895935", "42895825", "42895302", "42895259", "42895078", "42894029", "42894028", "42885806", "42858041", "42858016", "42858008", "42857992", "42853222", "42816405", "42709004", "42695342", "42622591", "42549920", "42161430", "41786365" ] }, "broad_major": { "query": "(hypertension[majr]) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 25, "translation": "\"hypertension\"[MeSH Major Topic] AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42925445", "42925373", "42925335", "42921236", "42912953", "42912827", "42912760", "42911818", "42911714", "42911359", "42909728", "42908184", "42905856", "42895254", "42885806", "42858041", "42858037", "42858016", "42858008", "42857992", "42816405", "42779507", "42695342", "42549920", "42161430" ] }, "newly_indexed": { "query": "(hypertension[ti] OR hypertension[majr]) AND (\"2026/10/19\"[edat] : \"2026/10/26\"[edat])", "count": 158, "translation": "(\"hypertension\"[Title] OR \"hypertension\"[MeSH Major Topic]) AND 2026/10/19:2026/10/26[Date - Entry]", "pmids_returned": [ "42927957", "42927925", "42927902", "42927786", "42927780", "42927470", "42927003", "42926914", "42926434", "42926234", "42926177", "42925958", "42925856", "42925726", "42925667", "42925445", "42925423", "42925373", "42925348", "42925335", "42924848", "42924837", "42924731", "42924522", "42924389", "42924298", "42924171", "42924162", "42924047", "42923979", "42923652", "42923560", "42923038", "42922912", "42922690", "42922444", "42922390", "42921844", "42921683", "42921666", "42921386", "42921236", "42921009", "42920960", "42920717", "42920579", "42920542", "42920503", "42920346", "42919645", "42919582", "42919376", "42919137", "42919100", "42918685", "42918485", "42915958", "42915860", "42915806", "42914747", "42914745", "42914514", "42914169", "42914167", "42913899", "42913275", "42912953", "42912827", "42912760", "42912704", "42912385", "42912184", "42911818", "42911714", "42911657", "42911359", "42911186", "42911168", "42910788", "42910470", "42910463", "42910319", "42910119", "42910102", "42910036", "42910011", "42909728", "42909583", "42909506", "42909260", "42908850", "42908745", "42908685", "42908617", "42908599", "42908309", "42908184", "42908000", "42907855", "42907705", "42907569", "42907171", "42907058", "42907045", "42905977", "42905856", "42905643", "42905429", "42905363", "42904684", "42904254", "42904164", "42903718", "42903293", "42903205", "42903007", "42902172", "42901767", "42901553", "42901484", "42900800", "42900495", "42900455", "42899612", "42898971", "42898806", "42898641", "42898559", "42898402", "42898097", "42898032", "42898020", "42897997", "42897897", "42897530", "42897503", "42897499", "42897471", "42897470", "42897073", "42897052", "42896799", "42896194", "42895935", "42895825", "42895302", "42895259", "42895254", "42895078", "42894838", "42894750", "42894746", "42894666", "42894645", "42894271", "42894232", "42894029", "42894028" ] }, "cochrane_whole_journal": { "query": "(\"Cochrane Database Syst Rev\"[jour]) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 5, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42910616", "42905959", "42905126", "42905124", "42905121" ] }, "retractions": { "query": "(hypertension AND (\"Retracted Publication\"[pt] OR \"Expression of Concern\"[pt] OR \"Retraction of Publication\"[pt] OR \"Published Erratum\"[pt])) AND (\"2026/10/19\"[edat] : \"2026/10/26\"[edat])", "count": 5, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"Retracted Publication\"[Publication Type] OR \"Expression of Concern\"[Publication Type] OR \"Published Erratum\"[Publication Type]) AND 2026/10/19:2026/10/26[Date - Entry]", "pmids_returned": [ "42923042", "42905793", "42904254", "42901693", "42896194" ] }, "alert_pa_results": { "query": "(\"ALERT-PA\"[tiab] OR \"NCT05925569\"[si] OR \"electronic alert\"[tiab]) AND \"primary aldosteronism\"", "count": 0, "translation": "\"electronic alert\"[Title/Abstract] AND \"primary aldosteronism\"[All Fields]", "pmids_returned": [] }, "intercare_followup": { "query": "InterCARE AND (hypertension OR blood pressure)", "count": 8, "translation": "\"InterCARE\"[All Fields] AND (\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields] OR (\"blood pressure\"[MeSH Terms] OR (\"blood\"[All Fields] AND \"pressure\"[All Fields]) OR \"blood pressure\"[All Fields] OR \"blood pressure determination\"[MeSH Terms] OR (\"blood\"[All Fields] AND \"pressure\"[All Fields] AND \"determination\"[All Fields]) OR \"blood pressure determination\"[All Fields] OR \"arterial pressure\"[MeSH Terms] OR (\"arterial\"[All Fields] AND \"pressure\"[All Fields]) OR \"arterial pressure\"[All Fields]))", "pmids_returned": [ "42860566", "42586107", "41768545", "41665620", "39075506", "39039609", "38902846", "12099964" ] }, "consep_results": { "query": "CONSEP AND aldosteronism", "count": 1, "translation": "\"CONSEP\"[All Fields] AND (\"aldosteron\"[All Fields] OR \"aldosterone\"[Supplementary Concept] OR \"aldosterone\"[All Fields] OR \"aldosterone\"[MeSH Terms] OR \"aldosterone s\"[All Fields] OR \"aldosterones\"[All Fields] OR \"hyperaldosteronism\"[MeSH Terms] OR \"hyperaldosteronism\"[All Fields] OR \"aldosteronism\"[All Fields])", "pmids_returned": [ "42697927" ] }, "gbd_ncd": { "query": "hypertension AND (\"NCD-RisC\" OR \"Global Burden of Disease\" OR GBD) AND (\"2026/10/19\"[dp] : \"2026/10/26\"[dp])", "count": 1, "translation": "(\"hypertense\"[All Fields] OR \"hypertension\"[MeSH Terms] OR \"hypertension\"[All Fields] OR \"hypertension s\"[All Fields] OR \"hypertensions\"[All Fields] OR \"hypertensive\"[All Fields] OR \"hypertensive s\"[All Fields] OR \"hypertensives\"[All Fields]) AND (\"NCD-RisC\"[All Fields] OR \"Global Burden of Disease\"[All Fields] OR \"GBD\"[All Fields]) AND 2026/10/19:2026/10/26[Date - Publication]", "pmids_returned": [ "42912409" ] }, "cochrane_indexed": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"2026/10/19\"[edat] : \"2026/10/26\"[edat])", "count": 5, "translation": "\"Cochrane Database Syst Rev\"[Journal] AND 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"completion": "2025-10-31", "enrollment": 960, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT05031819" }, { "nct": "NCT05047731", "title": "Antihypertensive Deprescribing in Long-term Care", "status": "COMPLETED", "last_update": "2026-01-08", "results_first": null, "primary_completion": "2025-11-30", "completion": "2025-11-30", "enrollment": 522, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT05047731" }, { "nct": "NCT05103332", "title": "Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)", "status": "COMPLETED", "last_update": "2025-11-03", "results_first": "2025-07-09", "primary_completion": "2023-12-11", "completion": "2024-09-13", "enrollment": 663, "enrollment_type": "ACTUAL", "has_results": true, "results_available_date": "2025-05-09", "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT05103332" }, { "nct": "NCT05405920", "title": "Caribbean and South America Team-based Strategy to Control Hypertension", "status": "COMPLETED", "last_update": "2026-10-01", "results_first": null, "primary_completion": "2026-09-09", "completion": "2026-09-09", "enrollment": 1706, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT05405920" }, { "nct": "NCT05414526", "title": "Integrating Hypertension and Cardiovascular Diseases Care Into Existing HIV Services Package in Botswana (InterCARE)", "status": "COMPLETED", "last_update": "2026-05-12", "results_first": null, "primary_completion": "2025-09-10", "completion": "2025-09-10", "enrollment": 4655, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT05414526" }, { "nct": "NCT05425030", "title": "A Community Health Worker-Led LSSS Intervention in Bangladesh", "status": "COMPLETED", "last_update": "2026-02-17", "results_first": null, "primary_completion": "2024-05-30", "completion": "2024-12-01", "enrollment": 618, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT05425030" }, { "nct": "NCT05658705", "title": "Preoperative Supine Time for Adrenal Venous Sampling", "status": "UNKNOWN", "last_update": "2024-04-26", "results_first": null, "primary_completion": "2025-03-29", "completion": "2025-03-29", "enrollment": 120, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT05658705" }, { "nct": "NCT05732727", "title": "Intensification of Blood Pressure Lowering Therapeutics Based on Diuretics Versus Usual Management for Uncontrolled Hypertension IN Patients With Moderate to Severe Chronic Kidney Disease", "status": "RECRUITING", "last_update": "2026-08-03", "results_first": null, "primary_completion": "2029-03", "completion": "2029-03", "enrollment": 720, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT05732727" }, { "nct": "NCT05769608", "title": "A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects With Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen", "status": "COMPLETED", "last_update": "2026-01-20", "results_first": null, "primary_completion": "2025-01-15", "completion": "2025-01-15", "enrollment": 285, "enrollment_type": "ACTUAL", 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"https://clinicaltrials.gov/api/v2/studies/NCT05925569" }, { "nct": "NCT05968430", "title": "Open-Label Extension (OLE) Study to Assess Safety, Efficacy, and Tolerability of Lorundrostat in Subjects With Hypertension", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-09-29", "results_first": null, "primary_completion": "2025-12-30", "completion": "2027-05", "enrollment": 1076, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT05968430" }, { "nct": "NCT06108427", "title": "REnin-guided TherApy With MinEralocorticoid Receptor Antagonists in Primary Aldosteronism - Feasibility Study", "status": "RECRUITING", "last_update": "2026-03-17", "results_first": null, "primary_completion": "2027-09", "completion": "2027-09", "enrollment": 58, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06108427" }, { "nct": "NCT06150924", "title": "Efficacy and Safety of Lorundrostat in Addition to Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2i) in Subjects With Hypertension and Chronic Kidney Disease (CKD) With Albuminuria", "status": "COMPLETED", "last_update": "2026-06-03", "results_first": "2026-06-03", "primary_completion": "2025-02-27", "completion": "2025-04-23", "enrollment": 60, "enrollment_type": "ACTUAL", "has_results": true, "results_available_date": "2026-05-06", "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06150924" }, { "nct": "NCT06153693", "title": "Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension", "status": "COMPLETED", "last_update": "2026-05-01", "results_first": null, "primary_completion": "2024-12-10", "completion": "2025-01-24", "enrollment": 1083, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06153693" }, { "nct": "NCT06168409", "title": "A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension", "status": "COMPLETED", "last_update": "2026-08-06", "results_first": "2026-08-06", "primary_completion": "2025-08-17", "completion": "2025-08-17", "enrollment": 218, "enrollment_type": "ACTUAL", "has_results": true, "results_available_date": "2026-06-08", "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06168409" }, { "nct": "NCT06268873", "title": "A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin on CKD Progression in Participants With CKD and High Blood Pressure.", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-06-26", "results_first": null, "primary_completion": "2028-02-24", "completion": "2028-02-24", "enrollment": 2554, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06268873" }, { "nct": "NCT06272487", "title": "Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)", "status": "COMPLETED", "last_update": "2026-03-02", "results_first": null, "primary_completion": "2025-06-19", "completion": "2025-12-01", "enrollment": 375, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06272487" }, { "nct": "NCT06336356", "title": "A Study to Evaluate Cortisol Reserve in Response to Adrenocorticotropic Hormone (ACTH) Stimulation Test Following Baxdrostat Treatment Compared to Placebo in Participants With Uncontrolled Hypertension", "status": "COMPLETED", "last_update": "2025-12-17", "results_first": "2025-12-17", "primary_completion": "2024-12-04", "completion": "2024-12-04", "enrollment": 48, "enrollment_type": "ACTUAL", "has_results": true, "results_available_date": "2025-10-08", "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06336356" }, { "nct": "NCT06423352", "title": "A Study to Evaluate Zilebesiran in Japanese Patients With Mild to Moderate Hypertension", "status": "COMPLETED", "last_update": "2026-04-30", "results_first": "2026-04-30", "primary_completion": "2025-07-17", "completion": "2025-07-17", "enrollment": 36, "enrollment_type": "ACTUAL", "has_results": true, "results_available_date": "2026-03-06", "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06423352" }, { "nct": "NCT06578975", "title": "HT-ENDO: A Multiomics-based Biomarker for the Diagnosis of Endocrine Hypertension: a Pragmatic, Diagnostic, Randomized, Outcome-based Trial", "status": "UNKNOWN", "last_update": "2024-08-30", "results_first": null, "primary_completion": "2026-01-01", "completion": "2026-01-01", "enrollment": 250, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06578975" }, { "nct": "NCT06742723", "title": "A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure", "status": "RECRUITING", "last_update": "2026-09-25", "results_first": null, "primary_completion": "2029-12-18", "completion": "2029-12-18", "enrollment": 5000, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06742723" }, { "nct": "NCT06785454", "title": "A Study to Assess the Efficacy and Safety of Lorundrostat in Participants With Obstructive Sleep Apnea and Hypertension", "status": "COMPLETED", "last_update": "2026-08-21", "results_first": null, "primary_completion": "2025-12-17", "completion": "2025-12-29", "enrollment": 48, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06785454" }, { "nct": "NCT06877221", "title": "Safety and Efficacy of Modulated Ultrasound Renal Denervation for HTN", "status": "RECRUITING", "last_update": "2025-06-19", "results_first": null, "primary_completion": "2027-12", "completion": "2030-12", "enrollment": 204, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06877221" }, { "nct": "NCT06907147", "title": "SPYRAL GEMINI Pilot Study", "status": "RECRUITING", "last_update": "2026-10-20", "results_first": null, "primary_completion": "2029-12-22", "completion": "2029-12-22", "enrollment": 175, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06907147" }, { "nct": "NCT06959134", "title": "Community Health Workers-led Multicomponent Intervention for Hypertension Control in Rwanda", "status": "COMPLETED", "last_update": "2025-05-06", "results_first": null, "primary_completion": "2025-01-10", "completion": "2025-01-30", "enrollment": 200, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT06959134" }, { "nct": "NCT07013929", "title": "Spyral InSight Study", "status": "RECRUITING", "last_update": "2026-10-20", "results_first": null, "primary_completion": "2027-02-28", "completion": "2027-07-01", "enrollment": 19, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07013929" }, { "nct": "NCT07027254", "title": "PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism", "status": "RECRUITING", "last_update": "2025-06-18", "results_first": null, "primary_completion": "2027-06-01", "completion": "2027-12-01", "enrollment": 90, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07027254" }, { "nct": "NCT07051811", "title": "To Evaluate the Safety and Efficacy of a Single-Use IVUS Ablation for Primary Hypertension", "status": "RECRUITING", "last_update": "2025-07-04", "results_first": null, "primary_completion": "2027-12-31", "completion": "2029-12-31", "enrollment": 213, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07051811" }, { "nct": "NCT07081243", "title": "Symplicity China Study", "status": "RECRUITING", "last_update": "2025-11-17", "results_first": null, "primary_completion": "2028-06-30", "completion": "2031-12-30", "enrollment": 500, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07081243" }, { "nct": "NCT07114757", "title": "REnal Denervation After Stroke (REDs) Study - A Randomized Clinical Trial of Renal Denervation in the Subacute Phase of Stroke", "status": "NOT_YET_RECRUITING", "last_update": "2025-08-11", "results_first": null, "primary_completion": "2027-09-25", "completion": "2029-09-25", "enrollment": 108, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07114757" }, { "nct": "NCT07174622", "title": "Longitudinal Real-world Clinical Outcomes Study on Symplicity Renal Denervation", "status": "RECRUITING", "last_update": "2026-10-20", "results_first": null, "primary_completion": "2029-06", "completion": "2029-06", "enrollment": 1000, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07174622" }, { "nct": "NCT07178964", "title": "POTASSIUM-RICH SALT SUBSTITUTES IN KIDNEY TRANSPLANT RECIPIENTS", "status": "NOT_YET_RECRUITING", "last_update": "2025-09-17", "results_first": null, "primary_completion": "2026-06-30", "completion": "2026-09-30", "enrollment": 80, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07178964" }, { "nct": "NCT07181109", "title": "Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease", "status": "RECRUITING", "last_update": "2026-10-15", "results_first": null, "primary_completion": "2030-09-23", "completion": "2030-09-23", "enrollment": 11000, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07181109" }, { "nct": "NCT07222917", "title": "A Phase IIb Study to Evaluate the Effect of Dapagliflozin in Combination With Baxdrostat Compared With Baxdrostat on Albuminuria in Participants With Chronic Kidney Disease and High Blood Pressure.", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-09-01", "results_first": null, "primary_completion": "2026-12-10", "completion": "2026-12-10", "enrollment": 222, "enrollment_type": "ACTUAL", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07222917" }, { "nct": "NCT07228065", "title": "Fixed-Dose Combinations Pragmatic Randomized Implementation Trial for Blood Pressure Control", "status": "ENROLLING_BY_INVITATION", "last_update": "2026-08-11", "results_first": null, "primary_completion": "2027-04-30", "completion": "2027-06-30", "enrollment": 720, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07228065" }, { "nct": "NCT07328230", "title": "Superselective Adrenal Arterial Embolization Versus Oral Spironolactone for Treatment of Idiopathic Hyperaldosteronism", "status": "RECRUITING", "last_update": "2026-01-09", "results_first": null, "primary_completion": "2025-12-31", "completion": "2025-12-31", "enrollment": 172, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07328230" }, { "nct": "NCT07336433", "title": "SMART-IC-Pilot Study", "status": "NOT_YET_RECRUITING", "last_update": "2026-01-13", "results_first": null, "primary_completion": "2027-06-30", "completion": "2027-12-31", "enrollment": 15, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07336433" }, { "nct": "NCT07460882", "title": "The Impact of Low Sodium Salt Substitute Use on Serum Potassium Levels Among Patients With Hypertension", "status": "RECRUITING", "last_update": "2026-08-21", "results_first": null, "primary_completion": "2027-03-31", "completion": "2027-09-30", "enrollment": 607, "enrollment_type": "ESTIMATED", "has_results": false, "results_available_date": null, "results_last_update": null, "api_url": "https://clinicaltrials.gov/api/v2/studies/NCT07460882" }, { "nct": 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Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan." } ] } }, { "fullName": "Lai TS", "lastName": "Lai", "firstName": "Tai-Shuan", "initials": "TS", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan." } ] } }, { "fullName": "Cheng SY", "lastName": "Cheng", "firstName": "Shao-Yi", "initials": "SY", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Family Medicine, College of Medicine and Hospital, National Taiwan University, Taipei, Taiwan." } ] } }, { "fullName": "Chan DC", "lastName": "Chan", "firstName": "Ding-Cheng", "initials": "DC", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan; Superintendent Office, National Taiwan University Hospital Bei-Hu Branch, Taipei, Taiwan." } ] } }, { "fullName": "Lin YH", "lastName": "Lin", "firstName": "Yen-Hung", "initials": "YH", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Cardiovascular Center, National Taiwan University Hospital, Taipei, Taiwan; Primary Aldosteronism Center, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: austinr34@gmail.com." } ] } } ] }, "journalInfo": { "journalIssueId": 4285943, "dateOfPublication": "2026 Oct", "monthOfPublication": 10, "yearOfPublication": 2026, "journal": { "medlineAbbreviation": "J Formos Med Assoc", "title": "Journal of the Formosan Medical Association = Taiwan yi zhi", "issn": "0929-6646", "isoabbreviation": "J Formos Med Assoc", "nlmid": "9214933" }, "printPublicationDate": "2026-10-01" }, "pubYear": "2026", "pageInfo": "S0929-6646(26)00925-3", "abstractText": "The 2026 Taiwan Hypertension Society Guidelines for the Management of Hypertension in Older Adults provide an evidence-based framework tailored to the needs of an aging population. Recommendations were developed using PICO-formulated clinical questions, systematic evidence appraisal, and the GRADE approach, integrating evidence from randomized trials, observational studies, and expert consensus. A total of 63 actionable recommendations address diagnostic evaluation, blood pressure measurement and monitoring, lifestyle modification, blood pressure targets, and pharmacological therapy, with input from a multidisciplinary guideline panel and an external interdisciplinary expert committee. The guidelines emphasize age-related characteristics of hypertension, including arterial stiffness, salt sensitivity, frailty, orthostatic hypotension, cognitive vulnerability, atrial fibrillation, and multimorbidity. Standardized blood pressure measurement using validated oscillometric devices and regular out-of-office monitoring are strongly recommended. Blood pressure targets are specified according to age groups and common comorbid conditions. Non-pharmacological interventions, particularly dietary sodium reduction, potassium-enriched salt substitutes, healthy dietary patterns, and physical activity, are encouraged. Pharmacological treatment prioritizes individualized therapy and avoidance of overtreatment, especially in frail older adults. Endorsed by relevant national societies, these guidelines offer a practical approach to improving hypertension management and cardiovascular outcomes in older adults.", "affiliation": "Division of Faculty Development, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; PhD Program of Interdisciplinary Medicine, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan; Institute of Public Health, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan; Institute of Health and Welfare Policy, National Yang Ming Chiao Tung University College of Medicine, Taipei, Taiwan.", "publicationStatus": "aheadofprint", "language": "eng", "pubModel": "Print-Electronic", "pubTypeList": { "pubType": [ "Review", "Journal Article" ] }, "keywordList": { "keyword": [ "Hypertension", "Frailty", "Clinical Practice Guidelines", "Older Adults", "Blood Pressure Targets" ] }, 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In 2018, the Association for the Advancement of Medical Instrumentation (AAMI), the European Society of Hypertension (ESH), and the International Organization for Standardization (ISO) introduced the AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018) to establish globally accepted requirements for validation studies. This standard is developed specifically for cuff BP devices and is inadequate for cuffless ones, which require different validation procedures. In 2018, the ESH Working Group on Blood Pressure Monitoring published a practical guide and checklist for performing and reporting validation studies of cuff BP devices. Thereafter, two recent amendments (1:2020 and 2:2024) introduced additional requirements for limb and cuff size distribution to ensure that the entire limb range per cuff is adequately assessed. Despite these major initiatives, regular reviews of published validation studies performed by STRIDE BP have identified persistent violations of the validation requirements and incomplete reporting of important data. 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"authorAffiliation": [ { "affiliation": "Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA." } ] } }, { "fullName": "Eadon MT", "lastName": "Eadon", "firstName": "Michael T", "initials": "MT", "authorId": { "type": "ORCID", "value": "0000-0003-3066-2876" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA." } ] } }, { "collectiveName": "IGNITE Pragmatic Trials Network" } ] }, "authorIdList": { "authorId": [ { "type": "ORCID", "value": "0000-0001-5099-4910" }, { "type": "ORCID", "value": "0000-0001-6319-4314" }, { "type": "ORCID", "value": "0000-0001-6820-274X" }, { "type": "ORCID", "value": "0000-0001-6990-9069" }, { "type": "ORCID", "value": "0000-0001-7474-2339" }, { "type": "ORCID", "value": "0000-0001-9078-845X" }, { "type": "ORCID", 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"dateOfPublication": "2026 Oct", "monthOfPublication": 10, "yearOfPublication": 2026, "journal": { "medlineAbbreviation": "Clin Pharmacol Ther", "title": "Clinical pharmacology and therapeutics", "essn": "1532-6535", "issn": "0009-9236", "isoabbreviation": "Clin Pharmacol Ther", "nlmid": "0372741" }, "printPublicationDate": "2026-10-01" }, "pubYear": "2026", "abstractText": "Almost half of individuals with hypertension fail to achieve recommended blood pressure (BP) goals. Pharmacogenetic gene-drug interactions may alter the efficacy of antihypertensive agents. We conducted a multicenter randomized controlled sub-study of participants (N\u2009=\u20091874) with hypertension and self-reported African ancestry to determine whether pharmacogenetic return of results (RoR) would improve systolic blood pressure (SBP) at 3\u2009months. Participants were randomized to immediate pharmacogenetic RoR (intervention) or delayed RoR at trial completion (control). Clinical decision support conveyed recommendations for YEATS4-guided thiazide diuretic selection and NAT2-guided hydralazine dosing. Prespecified subgroup analyses included those with uncontrolled BP (baseline SBP \u2265140 or DBP \u226590\u2009mm Hg) and actionable genotypes. Immediate RoR did not improve SBP at 3\u2009months in a broad population of hypertensive adults with controlled and uncontrolled SBP (covariate-adjusted change in SBP between groups: -0.3\u2009\u00b1\u20090.74\u2009mm Hg, 95% CI: -1.8, 1.2). In participants with an actionable YEATS4 genotype (N\u2009=\u2009867) predicting reduced thiazide efficacy, immediate RoR led to greater SBP reduction at 3\u2009months (-2.46\u2009mm Hg, 95% CI: -4.57 to -0.36). In participants with uncontrolled hypertension at baseline (N\u2009=\u2009659), immediate RoR led to a greater reduction in SBP (-2.9\u2009\u00b1\u20090.74\u2009mm Hg, 95% CI: -5.6, -0.3). Although no SBP reduction was observed in the whole cohort, participants with an actionable YEATS4 genotype or uncontrolled BP who received immediate RoR had a significantly greater SBP improvement than those with delayed RoR. Future studies of antihypertensive pharmacogenetics should recruit individuals with uncontrolled BP and actionable genotypes.", "affiliation": "Department of Pharmacy & Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, USA.", "publicationStatus": "aheadofprint", "language": "eng", "pubModel": "Print-Electronic", "pubTypeList": { "pubType": [ "research-article", "Journal Article" ] }, "subsetList": { "subset": [ { "code": "IM", "name": "Index Medicus" } ] }, "fullTextUrlList": { "fullTextUrl": [ { "availability": "Subscription required", "availabilityCode": "S", "documentStyle": "doi", "site": "DOI", "url": "https://doi.org/10.1002/cpt.70527" }, { "availability": "Open access", "availabilityCode": "OA", "documentStyle": "html", "site": "Europe_PMC", "url": "https://europepmc.org/articles/PMC13677980" }, { "availability": "Open access", "availabilityCode": "OA", "documentStyle": "pdf", "site": "Europe_PMC", "url": 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"Jubayer S, Ahsan-Uz-Zaman M, Hossain SZ, Bhuiyan MR, Aimiosior O, Abrar A, Chowdhury RI, Amin MR, Banigbe BF, Gupta R, Moran AE, Frieden TR, Choudhury S.", "authorList": { "author": [ { "fullName": "Jubayer S", "lastName": "Jubayer", "firstName": "Shamim", "initials": "S", "authorId": { "type": "ORCID", "value": "0000-0002-8595-1993" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "National Heart Foundation Hospital and Research Institute, Dhaka, Bangladesh." } ] } }, { "fullName": "Ahsan-Uz-Zaman M", "lastName": "Ahsan-Uz-Zaman", "firstName": "Md", "initials": "M", "authorId": { "type": "ORCID", "value": "0009-0000-2689-600X" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "National Heart Foundation Hospital and Research Institute, Dhaka, Bangladesh." } ] } }, { "fullName": "Hossain SZ", "lastName": "Hossain", "firstName": "Syed Zakir", "initials": "SZ", "authorId": { "type": "ORCID", "value": "0009-0006-1615-0662" }, 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{ "type": "ORCID", "value": "0009-0006-1615-0662" } ] }, "journalInfo": { "issue": "1", "volume": "21", "journalIssueId": 4095021, "dateOfPublication": "2026 ", "monthOfPublication": 0, "yearOfPublication": 2026, "journal": { "medlineAbbreviation": "Glob Heart", "title": "Global heart", "essn": "2211-8179", "issn": "2211-8160", "isoabbreviation": "Glob Heart", "nlmid": "101584391" }, "printPublicationDate": "2026-01-01" }, "pubYear": "2026", "pageInfo": "74", "abstractText": "To improve hypertension control and prevent cardiovascular disease in Bangladesh, the National Heart Foundation of Bangladesh and Resolve to Save Lives collaborated with the Ministry of Health and Family Welfare to launch the Bangladesh Hypertension Control Initiative (BHCI). The BHCI implemented the WHO-HEARTS hypertension control package in four primary health care facilities (Upazila Health Complexes or UHCs) in 2018, then scaled up to 51 UHCs in 2021, 172 UHCs by 2024, and 320 UHCs by May 2026, covering about 54 million of 108 million adults (~43% coverage). By May 2026, the BHCI had enrolled 739,057 hypertensive patients and achieved 59% blood pressure (BP) control (<140/90 mmHg based on BP measured in the prior three months among all enrolled patients). The BHCI is a scalable model for hypertension control programs in other low- and middle-income countries. For sustained high-quality national scale-up, uninterrupted supply of medicines by the government and accurate information systems are crucial.", "affiliation": "National Heart Foundation Hospital and Research Institute, Dhaka, Bangladesh.", "publicationStatus": "epublish", "language": "eng", "pubModel": "Electronic-eCollection", "pubTypeList": { "pubType": [ "Review", "Journal Article" ] }, "meshHeadingList": { "meshHeading": [ { "majorTopic_YN": "N", "descriptorName": "Humans" }, { "majorTopic_YN": "Y", "descriptorName": "Cardiovascular Diseases", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "EP", "qualifierName": "epidemiology" }, { "majorTopic_YN": "N", "abbreviation": "PC", "qualifierName": "prevention & control" } ] } }, { "majorTopic_YN": "Y", "descriptorName": "Hypertension", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "EP", "qualifierName": "epidemiology" }, { "majorTopic_YN": "N", "abbreviation": "PC", "qualifierName": "prevention & control" } ] } }, { "majorTopic_YN": "Y", "descriptorName": "Blood Pressure", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "PH", "qualifierName": "physiology" } ] } }, { "majorTopic_YN": "Y", "descriptorName": "Primary Health Care" }, { "majorTopic_YN": "N", "descriptorName": "Bangladesh", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "EP", "qualifierName": "epidemiology" } ] } } ] }, "keywordList": { "keyword": [ "Bangladesh", "Primary Health Care", "Electronic Medical Records", "Noncommunicable Diseases", "Hypertension Control", "Who-Hearts" ] }, "subsetList": { "subset": [ { "code": "IM", "name": "Index Medicus" } ] }, "fullTextUrlList": { "fullTextUrl": [ { "availability": "Subscription required", "availabilityCode": "S", "documentStyle": "doi", "site": "DOI", "url": "https://doi.org/10.5334/gh.1595" } ] }, "isOpenAccess": "N", "inEPMC": "N", "inPMC": "N", "citedByCount": 0, "hasReferences": "N", "hasTextMinedTerms": "N", "hasDbCrossReferences": "N", "hasPDF": "N", "hasBook": "N", "hasSuppl": "N", "hasLabsLinks": "N", "hasData": "N", "authMan": "N", "epmcAuthMan": "N", "nihAuthMan": "N", "hasTMAccessionNumbers": "N", "dateOfCompletion": "2026-10-24", "dateOfCreation": "2026-10-24", "dateOfRevision": "2026-10-24", "electronicPublicationDate": "2026-10-21", "firstPublicationDate": "2026-10-21", "firstIndexDate": "2026-10-25", "hasEvaluations": "N" } ] }, "42925856": { "query": "EXT_ID:42925856 AND SRC:MED", "hit_count": 1, "records": [ { "id": "42925856", "source": "MED", "pmid": "42925856", "doi": "10.1016/j.preghy.2026.101535", "title": "Evaluating the feasibility and impact of a remote, algorithm-based blood pressure titration program in postpartum women with hypertensive disorders of pregnancy: the postpartum algorithm for text-based hypertension management (PATH) randomized clinical trial.", "authorString": "Vullikanti M, Del Cueto P, Vivaldi M, Scott N, James K, Goldfarb I, Sarma A.", "authorList": { "author": [ { "fullName": "Vullikanti M", "lastName": "Vullikanti", "firstName": "Meesha", "initials": "M", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Mass General Brigham Heart Vascular Institute, Boston, MA, United States of America; Women's Heart Health Program, Mass General Brigham, Boston, MA, United States of America; Department of Obstetrics and Gynecology, Mass General Brigham, Boston, MA, United States of America; Yale School of Medicine, New Haven, CT, United States of America." } ] } }, { "fullName": "Del Cueto P", "lastName": "Del Cueto", "firstName": "Paola", "initials": "P", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Obstetrics and Gynecology, Mass General Brigham, Boston, MA, United States of America; Department of Medicine, Harvard Medical School, Boston, MA, United States of America." } ] } }, { "fullName": "Vivaldi M", "lastName": "Vivaldi", "firstName": "Maria", "initials": "M", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Mass General Brigham Heart Vascular Institute, Boston, MA, United States of America; Women's Heart Health Program, Mass General Brigham, Boston, MA, United States of America; Department of Medicine, Harvard Medical School, Boston, MA, United States of America." } ] } }, { "fullName": "Scott N", "lastName": "Scott", "firstName": "Nandita", "initials": "N", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Mass General Brigham Heart Vascular Institute, Boston, MA, United States of America; Women's Heart Health Program, Mass General Brigham, Boston, MA, United States of America; Department of Medicine, Harvard Medical School, Boston, MA, United States of America." } ] } }, { "fullName": "James K", "lastName": "James", "firstName": "Kaitlyn", "initials": "K", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Mass General Brigham Heart Vascular Institute, Boston, MA, United States of America; Department of Obstetrics and Gynecology, Mass General Brigham, Boston, MA, United States of America." } ] } }, { "fullName": "Goldfarb I", "lastName": "Goldfarb", "firstName": "Ilona", "initials": "I", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Obstetrics and Gynecology, Mass General Brigham, Boston, MA, United States of America; Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, CA, United States of America." } ] } }, { "fullName": "Sarma A", "lastName": "Sarma", "firstName": "Amy", "initials": "A", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Mass General Brigham Heart Vascular Institute, Boston, MA, United States of America; Women's Heart Health Program, Mass General Brigham, Boston, MA, United States of America; Department of Medicine, Harvard Medical School, Boston, MA, United States of America. Electronic address: asarma1@mgb.org." } ] } } ] }, "journalInfo": { "volume": "46", "journalIssueId": 4285879, "dateOfPublication": "2026 Oct", "monthOfPublication": 10, "yearOfPublication": 2026, "journal": { "medlineAbbreviation": "Pregnancy Hypertens", "title": "Pregnancy hypertension", "essn": "2210-7797", "issn": "2210-7789", "nlmid": "101552483", "isoabbreviation": "Pregnancy Hypertens" }, "printPublicationDate": "2026-10-01" }, "pubYear": "2026", "pageInfo": "101535", "abstractText": "

Objective

Optimal postpartum management of hypertensive disorders of pregnancy (HDP) remains unknown. This pilot randomized control trial explored feasibility and safety of an algorithmic, text-based intervention targeting a blood pressure (BP)\u202f<\u202f130/80\u202fmmHg (in accordance with American College of Cardiology/American Heart Association recommendations - ACC/AHA) on hypertension management at 6\u202fweeks postpartum as compared with routine care.

Study design

200 postpartum patients with HDP (excluding chronic hypertension) were randomized at hospital discharge for delivery or postpartum HDP admission from a tertiary care center in a 1:1 fashion to the intervention (targeting a blood pressure\u202f<\u202f130/ 80\u202fmmHg) or routine care. Patients and clinicians were blinded with respect to randomization.

Main outcome measures

The primary outcome was the proportion of patients who achieved normotension as defined by the ACC/AHA (systolic blood pressure\u202f<\u202f130\u202fmmHg). Secondary outcomes were frequency of medication titration, outpatient visits, and non-billable healthcare encounters.

Results

The virtual intervention did not differ from routine care with respect to the primary outcome using office- ascertained BPs (72% intervention vs 74% routine care, p\u202f=\u202f0.83). At 6\u202fweeks postpartum, clinic systolic BP did not differ by group (121\u202fmmHg vs 119\u202fmmHg, p\u202f=\u202f0.3), though home-reported SBPs during the same period were lower among those randomized to the intervention (119\u202fmmHg vs 125\u202fmmHg, p\u202f<\u202f0.001). No adverse events occurred in either group.

Conclusions

As compared to routine care delivered at a tertiary care center, no differences were observed with respect to systolic BP at 6\u202fweeks postpartum using a virtual, algorithm-based intervention. A high proportion of patients in both randomized groups achieving normotension by ACC/AHA targets without adverse events.", "affiliation": "Mass General Brigham Heart Vascular Institute, Boston, MA, United States of America; Women's Heart Health Program, Mass General Brigham, Boston, MA, United States of America; Department of Obstetrics and Gynecology, Mass General Brigham, Boston, MA, United States of America; Yale School of Medicine, New Haven, CT, United States of America.", "publicationStatus": "aheadofprint", "language": "eng", "pubModel": "Print-Electronic", "pubTypeList": { "pubType": [ "Journal Article" ] }, "keywordList": { "keyword": [ "Hypertension", "Postpartum", "Preeclampsia", "Remote Monitoring" ] }, "subsetList": { "subset": [ { "code": "IM", "name": "Index Medicus" } ] }, "fullTextUrlList": { "fullTextUrl": [ { "availability": "Subscription required", "availabilityCode": "S", "documentStyle": "doi", "site": "DOI", "url": "https://doi.org/10.1016/j.preghy.2026.101535" 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M.", "authorList": { "author": [ { "fullName": "Mahfoud F", "lastName": "Mahfoud", "firstName": "Felix", "initials": "F", "authorId": { "type": "ORCID", "value": "0000-0002-4425-549X" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Cardiology, University Heart Center, University Hospital Basel, Switzerland." }, { "affiliation": "Cardiovascular Research Institute Basel (CRIB), University Heart Center, University Hospital Basel, Switzerland." } ] } }, { "fullName": "Kandzari DE", "lastName": "Kandzari", "firstName": "David E", "initials": "DE", "authorId": { "type": "ORCID", "value": "0000-0002-0868-6655" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Interventional Cardiology, Piedmont Heart Institute, Atlanta, GA, USA." } ] } }, { "fullName": "Townsend RR", "lastName": "Townsend", "firstName": "Raymond R", "initials": "RR", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Renal and Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA." } ] } }, { "fullName": "Kario K", "lastName": "Kario", "firstName": "Kazuomi", "initials": "K", "authorId": { "type": "ORCID", "value": "0000-0002-8251-4480" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Cardiovascular Medicine, Jichi Medical University School of Medicine, Tochigi, Japan." } ] } }, { "fullName": "Weber MA", "lastName": "Weber", "firstName": "Michael A", "initials": "MA", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Medicine, SUNY Downstate College of Medicine, New York, NY, USA." } ] } }, { "fullName": "Schmieder RE", "lastName": "Schmieder", "firstName": "Roland E", "initials": "RE", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany." } ] } }, { "fullName": "Tsioufis K", "lastName": "Tsioufis", "firstName": "Konstantinos", "initials": "K", "authorId": { "type": "ORCID", "value": "0000-0002-7636-6725" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Cardiology, National and Kapodistrian University of Athens Hippocratio Hospital, Athens, Greece." } ] } }, { "fullName": "Parmar G", "lastName": "Parmar", "firstName": "Gaurav", "initials": "G", "authorId": { "type": "ORCID", "value": "0000-0002-6170-4066" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Vascore and Section of Vascular Medicine, Massachusetts General Hospital, Boston, MA, USA." } ] } }, { "fullName": "Uretsky S", "lastName": "Uretsky", "firstName": "Seth", "initials": "S", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Cardiovascular Medicine, Morristown Medical Center/Atlantic Health System, Morristown, NJ, USA." } ] } }, { "fullName": "Gibson CM", "lastName": "Gibson", "firstName": "C Michael", "initials": "CM", "authorId": { "type": "ORCID", "value": "0000-0002-4857-9125" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "BAIM Institute for Clinical Research, Boston, MA, USA." } ] } }, { "fullName": "McKenna P", "lastName": "McKenna", "firstName": "Pamela", "initials": "P", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Interventional Cardiology Therapies, Medtronic, Santa Rosa, CA, USA." } ] } }, { "fullName": "B\u00f6hm M", "lastName": "B\u00f6hm", "firstName": "Michael", "initials": "M", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "HOMICAREM (HOMburg Institute for CArdioREnalMetabolic Medicine), Saarland University Hospital, Homburg, Germany." } ] } } ] }, "authorIdList": { "authorId": [ { "type": "ORCID", "value": "0000-0002-0868-6655" }, { "type": "ORCID", "value": "0000-0002-4425-549X" }, { "type": "ORCID", "value": "0000-0002-4857-9125" }, { "type": "ORCID", "value": "0000-0002-6170-4066" }, { "type": "ORCID", "value": "0000-0002-7636-6725" }, { "type": "ORCID", "value": "0000-0002-8251-4480" } ] }, "journalInfo": { "journalIssueId": 4286002, "dateOfPublication": "2026 Oct", "monthOfPublication": 10, "yearOfPublication": 2026, "journal": { "medlineAbbreviation": "Vasa", "title": "VASA. Zeitschrift fur Gefasskrankheiten", "essn": "1664-2872", "issn": "0301-1526", "nlmid": "0317051", "isoabbreviation": "Vasa" }, "printPublicationDate": "2026-10-01" }, "pubYear": "2026", "abstractText": "Background: Renal denervation (RDN) safely reduces blood pressure (BP) in patients with uncontrolled hypertension. A potential long-term concern is the development of de novo renal artery stenosis (RAS) secondary to vascular injury. This study assesses the long-term vascular safety and incidence of RAS in patients treated with radiofrequency RDN from the SPYRAL HTN-OFF MED and -ON MED trials. Patients and methods: All patients underwent renal angiograms for assessment of the renal anatomy prior to randomization. Patients with RAS >50% were excluded from enrollment. At long-term follow-up (439+/-288 days), patients underwent duplex ultrasound imaging (DUS), computerized tomography angiography (CTA), and/or magnetic resonance angiography (MRA). Independent core labs evaluated all images. Clinically significant RAS was predefined as a stenosis \u226570%, confirmed by angiography. Results: A total of 610 patients were treated with RDN in the SPYRAL trials. At least one imaging modality was performed in 557 of the 610 patients (91%): 329 patients underwent DUS imaging, 230 underwent CTA, 148 underwent MRA, and 15 underwent renal angiography. With one possible exception, no clinically significant RAS was detected. No patients had renal artery reintervention. The proportion of images fulfilling pre-specified criteria for technical adequacy by the core lab was 100% (angiography), 87.5% (DUS), 80.6% (CTA), and 32.4% MRA. Conclusions: RF RDN appears to be safe, without confirmed vascular injury or RAS among 557 patients who had long-term imaging. Diagnostic utility of imaging modalities determined by specific criteria for technical adequacy for core lab evaluation was lowest with MRA and highest with DUS.", "affiliation": "Department of Cardiology, University Heart Center, University Hospital Basel, Switzerland.", "publicationStatus": "aheadofprint", "language": "eng", "pubModel": "Print-Electronic", "pubTypeList": { "pubType": [ "Journal Article" ] }, "keywordList": { "keyword": [ "Imaging", "Renal artery", "Renal Denervation" ] }, "subsetList": { "subset": [ { "code": "IM", "name": "Index Medicus" } ] }, "fullTextUrlList": { "fullTextUrl": [ { "availability": "Subscription required", "availabilityCode": "S", "documentStyle": "doi", "site": "DOI", "url": "https://doi.org/10.1024/0301-1526/a001315" } ] }, "isOpenAccess": "N", "inEPMC": "N", "inPMC": "N", "citedByCount": 0, "hasReferences": "N", "hasTextMinedTerms": "Y", "hasDbCrossReferences": "N", "hasPDF": "N", "hasBook": "N", "hasSuppl": "N", "hasLabsLinks": "N", "hasData": "N", "authMan": "N", "epmcAuthMan": "N", "nihAuthMan": "N", "hasTMAccessionNumbers": "N", "dateOfCreation": "2026-10-22", "dateOfRevision": "2026-10-22", "electronicPublicationDate": "2026-10-21", "firstPublicationDate": "2026-10-21", "firstIndexDate": "2026-10-23", "hasEvaluations": "N" } ] }, "42907045": { "query": "EXT_ID:42907045 AND SRC:MED", "hit_count": 1, "records": [ { "id": "42907045", "source": "MED", "pmid": "42907045", "doi": "10.1053/j.ajkd.2026.07.006", "title": "KDOQI Commentary on the 2025 AHA/ACC Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults.", "authorString": "Chang TI, Cluett JL, Cohen DL, Drawz P, Hudson JQ, Kramer H, Rahman M, Awdishu L.", "authorList": { "author": [ { "fullName": "Chang TI", "lastName": "Chang", "firstName": "Tara I", "initials": "TI", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Division of Nephrology, Department of Medicine, School of Medicine, Stanford University, Stanford, California." } ] } }, { "fullName": "Cluett JL", "lastName": "Cluett", "firstName": "Jennifer L", "initials": "JL", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Medicine, Beth Israel Deaconess Medical Center, Medical School, Harvard University, Boston, Massachusetts." } ] } }, { "fullName": "Cohen DL", "lastName": "Cohen", "firstName": "Debbie L", "initials": "DL", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Renal Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania." } ] } }, { "fullName": "Drawz P", "lastName": "Drawz", "firstName": "Paul", "initials": "P", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Division of Nephrology and Hypertension, University of Minnesota, Minneapolis, Minnesota." } ] } }, { "fullName": "Hudson JQ", "lastName": "Hudson", "firstName": "Joanna Q", "initials": "JQ", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Clinical Pharmacy, Department of Translational Science, and Division of Nephrology, Department of Medicine, University of Tennessee Health Sciences, University of Tennessee, Memphis, Tennessee." } ] } }, { "fullName": "Kramer H", "lastName": "Kramer", "firstName": "Holly", "initials": "H", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Public Health Sciences and Division of Nephrology and Hypertension, Department of Medicine, Loyola University-Chicago, Maywood, Illinois." } ] } }, { "fullName": "Rahman M", "lastName": "Rahman", "firstName": "Mahboob", "initials": "M", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio." } ] } }, { "fullName": "Awdishu L", "lastName": "Awdishu", "firstName": "Linda", "initials": "L", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmacy Practice and Sciences, University of California-San Diego, La Jolla, California. Electronic address: lawdishu@health.ucsd.edu." } ] } } ] }, "journalInfo": { "issue": "5", "volume": "88", "journalIssueId": 4296295, "dateOfPublication": "2026 Nov", "monthOfPublication": 11, "yearOfPublication": 2026, "journal": { "medlineAbbreviation": "Am J Kidney Dis", "title": "American journal of kidney diseases : the official journal of the National Kidney Foundation", "essn": "1523-6838", "issn": "0272-6386", "isoabbreviation": "Am J Kidney Dis", "nlmid": "8110075" }, "printPublicationDate": "2026-11-01" }, "pubYear": "2026", "pageInfo": "645-681", "abstractText": "Hypertension prevention, diagnosis, and management are central to modifying the progression of chronic kidney disease (CKD). Although the nephrology community has long recognized CKD as an independent risk factor for cardiovascular disease, CKD has not historically been incorporated in cardiovascular risk prediction models. The new 2025 American Heart Association and American College of Cardiology (AHA/ACC) Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults addresses this gap by formally adopting the PREVENT calculator, which combines cardiovascular, kidney, and metabolic health parameters to guide risk assessment and clinical decision making. The AHA/ACC guideline reinforces the broad blood pressure target of <130/80 mm Hg as well as makes recommendations for complex and resistant hypertension. Given the impact of these recommendations on persons living with kidney disease, the Kidney Disease Outcomes Quality Initiative (KDOQI) convened an expert work group to review and comment on the guideline. This KDOQI commentary focuses on recommendations from the AHA/ACC guideline that are pertinent to individuals at risk of CKD or with non-dialysis-dependent CKD (stages 1-5), hence excluding commentary on hypertension management in patients receiving maintenance dialysis. In areas where the AHA/ACC guideline does not offer formal recommendations (eg, medication interactions, electrolyte imbalances, and kidney injury), the work group provides expert commentary about implications for people with CKD. Overall, the work group supports the majority of the AHA/ACC recommendations and identifies areas where evidence remains limited or management in CKD warrants additional consideration.", "affiliation": "Division of Nephrology, Department of Medicine, School of Medicine, Stanford University, Stanford, California.", "publicationStatus": "ppublish", "language": "eng", "pubModel": "Print", "pubTypeList": { "pubType": [ "Journal Article" ] }, "meshHeadingList": { "meshHeading": [ { "majorTopic_YN": "N", "descriptorName": "Humans" }, { "majorTopic_YN": "Y", "descriptorName": "Hypertension", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "DI", "qualifierName": "diagnosis" }, { "majorTopic_YN": "N", "abbreviation": "PC", "qualifierName": "prevention & control" }, { "majorTopic_YN": "N", "abbreviation": "TH", "qualifierName": "therapy" } ] } }, { "majorTopic_YN": "N", "descriptorName": "Antihypertensive Agents", "meshQualifierList": { "meshQualifier": [ { 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"42554264": { "query": "EXT_ID:42554264 AND SRC:MED", "hit_count": 1, "records": [ { "id": "42554264", "source": "MED", "pmid": "42554264", "doi": "10.1097/hjh.0000000000004411", "title": "2026 ISH guidelines for the management of hypertension in Africa: the International Society of Hypertension (ISH) African Regional Advisory Group and the Pan African Society of Cardiology (PASCAR).", "authorString": "Doku A, Kruger R, Asamoah KT, Akumiah FK, Auala T, Beheiry H, Mutagaywa R, Isiguzo G, Akintunde AA, Dzudie A, Russell JBW, Nguelefack-Mbuyo EP, Mamven MH, Amaechi MU, Elfadil SS, Barongo A, Shirima G, Ibrahim TA, Ojji D, Damasceno A, Odili A, Ogola E, Khan N, Schutte AE, Jafar TH, Williams B, Jones ESW, Stergiou GS.", "authorList": { "author": [ { "fullName": "Doku A", "lastName": "Doku", "firstName": "Alfred", "initials": "A", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Medicine and Therapeutics, University of Ghana Medical School, Accra, Ghana." }, { "affiliation": "Department of Public & Occupational Health, University of Amsterdam Medical Centre, University of Amsterdam, Amsterdam, The Netherlands." } ] } }, { "fullName": "Kruger R", "lastName": "Kruger", "firstName": "Ruan", "initials": "R", "authorId": { "type": "ORCID", "value": "0000-0001-7680-2032" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension in Africa Research Team (HART), Faculty of Health Sciences." }, { "affiliation": "SAMRC Extramural Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa." } ] } }, { "fullName": "Asamoah KT", "lastName": "Asamoah", "firstName": "Kofi T", "initials": "KT", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "National Cardiothoracic Centre, Korle-Bu Teaching Hospital, Accra, Ghana." }, { "affiliation": "Severance Cardiovascular Hospital, Division of Cardiology, Department of Medicine, Yonsei University 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Background

Hypertension is a significant public health issue affecting over a billion adults worldwide with adherence to antihypertensives being crucial for achieving sustained blood pressure control and reducing cardiovascular morbidity and mortality. To extend previous evidence, we conducted a meta-analysis on global prevalence of adherence to antihypertensives among adults.

Methods

A systematic search was conducted in Scopus, PubMed, Web of Science, Embase, and CINAHL. Pooled prevalence of antihypertensive medication adherence was estimated using generalized linear mixed-effects model in R software version 4.4.3. Cochran's Q, \u03c42, and I2$$ {I}^2 $$ statistics examined statistical heterogeneity with moderator analysis exploring sources of heterogeneity. Sensitivity analysis was analyzed using exact fixed-effects model.

Results

A total of 123 studies with 1\u2009052\u2009445 adults with hypertension were included. Pooled global prevalence of adherence to antihypertensives was estimated at 58% (95% CI, 52%-63%), with 39% for high adherence, 29% for moderate adherence, and 35% for low adherence. Results for sensitivity analysis were 57.91% (95% CI, 57.81%-58.01%) with \u03b4\u0302 being 24.3%. Prevalence across continents was 67% for Europe, 65% for South America, 60% for Africa, 56% for Asia, and 45% for North America. Adherence to antihypertensives was similar across low-income countries (61%), high-income countries (58), upper-middle-income countries (57%), and lower-middle-income countries (56%). In multivariate model, age and assessment tool only were significantly associated with medication adherence.

Conclusions

Globally, a large proportion of adults with hypertension exhibit moderate to low adherence to antihypertensive medications. Future studies should prioritize establishing consensus-based operational definitions and cutoff values to enhance adherence.", "affiliation": "School of Nursing National Taipei University of Nursing and Health Sciences Taipei Taiwan.", "publicationStatus": "ppublish", "language": "eng", "pubModel": "Print-Electronic", "pubTypeList": { "pubType": [ "Meta-Analysis", "Systematic Review", "Journal Article" ] }, "meshHeadingList": { "meshHeading": [ { "majorTopic_YN": "N", "descriptorName": "Humans" }, { "majorTopic_YN": "Y", "descriptorName": "Hypertension", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "DI", "qualifierName": "diagnosis" }, { "majorTopic_YN": "N", "abbreviation": "DT", "qualifierName": "drug therapy" }, { "majorTopic_YN": "N", "abbreviation": "EP", "qualifierName": "epidemiology" }, { "majorTopic_YN": "N", "abbreviation": "PP", "qualifierName": "physiopathology" } ] } }, { "majorTopic_YN": "Y", "descriptorName": "Antihypertensive Agents", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "TU", "qualifierName": "therapeutic use" } ] } }, { "majorTopic_YN": "N", "descriptorName": "Prevalence" }, { "majorTopic_YN": "Y", "descriptorName": "Blood Pressure", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "DE", "qualifierName": "drug effects" } ] } }, { "majorTopic_YN": "N", "descriptorName": "Adult" }, { "majorTopic_YN": "Y", "descriptorName": "Medication Adherence" }, { "majorTopic_YN": "Y", "descriptorName": "Global Health" } ] }, "keywordList": { "keyword": [ "Adherence", "Prevalence", "Adults", "Antihypertensives", "Meta\u2010analysis" ] }, "chemicalList": { "chemical": [ { "name": "Antihypertensive Agents", "registryNumber": "0" } ] }, "subsetList": { "subset": [ { "code": "IM", "name": "Index Medicus" } ] }, "fullTextUrlList": { "fullTextUrl": [ { "availability": "Subscription required", "availabilityCode": "S", "documentStyle": "doi", "site": "DOI", "url": "https://doi.org/10.1161/JAHA.125.047824" } ] }, "isOpenAccess": "N", "inEPMC": "N", "inPMC": "N", "citedByCount": 0, "hasReferences": "Y", "hasTextMinedTerms": "Y", "hasDbCrossReferences": "N", "hasPDF": "N", "hasBook": "N", "hasSuppl": "N", "hasLabsLinks": "N", "hasData": "N", "authMan": "N", "epmcAuthMan": "N", "nihAuthMan": "N", "hasTMAccessionNumbers": "N", "dateOfCompletion": "2026-10-22", "dateOfCreation": "2026-10-16", "dateOfRevision": "2026-10-23", "electronicPublicationDate": "2026-10-16", "firstPublicationDate": "2026-10-16", "firstIndexDate": "2026-10-19", "hasEvaluations": "N" } ] }, "42864372": { "query": "EXT_ID:42864372 AND SRC:MED", "hit_count": 1, "records": [ { "id": "42864372", "source": "MED", "pmid": "42864372", "doi": "10.1038/s41371-026-01245-3", "title": "Potential under-recognition of primary aldosteronism in young adults with hypertension.", "authorString": "Zhao J, Zhang D, Hu J, Zhu Q, Hong J, Anwaier S, Luo Q, Li N.", "authorList": { "author": [ { "fullName": "Zhao J", "lastName": "Zhao", "firstName": "Jianwen", "initials": "J", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region \"Hypertension Research Laboratory\"; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, China." } ] } }, { "fullName": "Zhang D", "lastName": "Zhang", "firstName": "Delian", "initials": "D", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region \"Hypertension Research Laboratory\"; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, China." } ] } }, { "fullName": "Hu J", "lastName": "Hu", "firstName": "Junli", "initials": "J", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region \"Hypertension Research Laboratory\"; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, China." } ] } }, { "fullName": "Zhu Q", "lastName": "Zhu", "firstName": "Qing", "initials": "Q", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region \"Hypertension Research Laboratory\"; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, China." } ] } }, { "fullName": "Hong J", "lastName": "Hong", "firstName": "Jing", "initials": "J", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region \"Hypertension Research Laboratory\"; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, China." } ] } }, { "fullName": "Anwaier S", "lastName": "Anwaier", "firstName": "Saimire", "initials": "S", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region \"Hypertension Research Laboratory\"; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, China." } ] } }, { "fullName": "Luo Q", "lastName": "Luo", "firstName": "Qin", "initials": "Q", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region \"Hypertension Research Laboratory\"; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, China." } ] } }, { "fullName": "Li N", "lastName": "Li", "firstName": "Nanfang", "initials": "N", "authorId": { "type": "ORCID", "value": "0000-0003-1505-8566" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region \"Hypertension Research Laboratory\"; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, China. lnanfang2016@sina.com." } ] } } ] }, "authorIdList": { "authorId": [ { "type": "ORCID", "value": "0000-0003-1505-8566" } ] }, "journalInfo": { "journalIssueId": 4277523, "dateOfPublication": "2026 Oct", "monthOfPublication": 10, "yearOfPublication": 2026, "journal": { "medlineAbbreviation": "J Hum Hypertens", "title": "Journal of human hypertension", "essn": "1476-5527", "issn": "0950-9240", "nlmid": "8811625", "isoabbreviation": "J Hum Hypertens" }, "printPublicationDate": "2026-10-01" }, "pubYear": "2026", "abstractText": "The aldosterone-to-renin ratio (ARR) is the primary screening test for primary aldosteronism (PA), but it is strongly influenced by renin activity, which varies with age. Fixed ARR thresholds may therefore under-recognize PA in younger adults. We retrospectively analyzed 14,750 hypertensive patients who underwent saline infusion testing for suspected PA. An ARR of 20 was consistently used as the local reference threshold, but confirmatory testing could proceed despite ARR\u2009<\u200920 when clinical suspicion was high. Baseline plasma renin activity (PRA), aldosterone concentration (ALD), and ARR were measured before saline infusion. Of 13,428 patients with calculable ARR, 8703 (64.8%) underwent saline infusion testing despite ARR\u2009<\u200920, and 1578 had confirmed PA. Among 3966 confirmed PA patients with classifiable age-ARR data, ARR\u2009<\u200920 occurred in 57.5, 50.6, 35.4, and 33.2% of patients aged <35, 35-44, 45-54, and \u226555 years, respectively. Increasing age remained associated with lower odds of ARR\u2009<\u200920 after adjustment for sex, body mass index, blood pressure, potassium, creatinine, and a documented adrenal nodule (adjusted OR per year, 0.975; 95% CI, 0.967-0.984). The gradient persisted after restricting analyses to patients without a documented adrenal nodule, with potassium \u22653.5\u2009mmol/L and eGFR \u226560\u2009mL/min/1.73\u2009m\u00b2. Younger adults with confirmed PA frequently had baseline ARR values below 20, largely with relatively preserved PRA. Although residual referral bias cannot be excluded, these findings support cautious, age-informed interpretation of ALD, PRA, and ARR.", "affiliation": "Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; NHC Key Laboratory of Hypertension Clinical Research; Key Laboratory of Xinjiang Uygur Autonomous Region \"Hypertension Research Laboratory\"; Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, China.", "publicationStatus": "aheadofprint", "language": "eng", "pubModel": "Print-Electronic", "pubTypeList": { "pubType": [ "Journal Article" ] }, "subsetList": { "subset": [ { "code": "IM", "name": "Index Medicus" } ] }, "fullTextUrlList": { "fullTextUrl": [ { "availability": "Subscription required", "availabilityCode": "S", "documentStyle": "doi", "site": "DOI", "url": "https://doi.org/10.1038/s41371-026-01245-3" } ] }, "isOpenAccess": "N", "inEPMC": "N", "inPMC": "N", "citedByCount": 0, "hasReferences": "Y", "hasTextMinedTerms": "N", "hasDbCrossReferences": "N", "hasPDF": "N", "hasBook": "N", "hasSuppl": "N", "hasLabsLinks": "N", "hasData": "N", "authMan": "N", "epmcAuthMan": "N", "nihAuthMan": "N", "hasTMAccessionNumbers": "N", "dateOfCreation": "2026-10-12", "dateOfRevision": "2026-10-12", "electronicPublicationDate": "2026-10-12", "firstPublicationDate": "2026-10-12", "firstIndexDate": "2026-10-19", "hasEvaluations": "N" } ] }, "41645899": { "query": "EXT_ID:41645899 AND SRC:MED", "hit_count": 1, "records": [ { "id": "41645899", "source": "MED", "pmid": "41645899", "pmcid": "PMC12885222", "fullTextIdList": { "fullTextId": [ "PMC12885222" ] }, "doi": "10.1161/hypertensionaha.125.26228", "title": "Broadening Primary Aldosteronism Screening: Alignment Across Contemporary Guidelines.", "authorString": "Owei L, Wachtel H, Cohen JB.", "authorList": { "author": [ { "fullName": "Owei L", "lastName": "Owei", "firstName": "Lily", "initials": "L", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Surgery (L.O., H.W.), Perelman School of Medicine, University of Pennsylvania, Philadelphia." } ] } }, { "fullName": "Wachtel H", "lastName": "Wachtel", "firstName": "Heather", "initials": "H", "authorId": { "type": "ORCID", "value": "0000-0003-3786-3638" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Surgery (L.O., H.W.), Perelman School of Medicine, University of Pennsylvania, Philadelphia." } ] } }, { "fullName": "Cohen JB", "lastName": "Cohen", "firstName": "Jordana B", "initials": "JB", "authorId": { "type": "ORCID", "value": "0000-0003-4649-079X" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Renal-Electrolyte and Hypertension Division, Department of Medicine and Department of Biostatistics, Epidemiology, and Informatics (J.B.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia." } ] } } ] }, "authorIdList": { "authorId": [ { "type": "ORCID", "value": "0000-0003-3786-3638" }, { "type": "ORCID", "value": "0000-0003-4649-079X" } ] }, "dataLinksTagsList": { "dataLinkstag": [ "altmetrics", "supporting_data" ] }, "journalInfo": { "issue": "5", "volume": "83", "journalIssueId": 4180022, "dateOfPublication": "2026 May", "monthOfPublication": 5, "yearOfPublication": 2026, "journal": { "medlineAbbreviation": "Hypertension", "title": "Hypertension (Dallas, Tex. : 1979)", "essn": "1524-4563", "issn": "0194-911X", "isoabbreviation": "Hypertension", "nlmid": "7906255" }, "printPublicationDate": "2026-05-01" }, "pubYear": "2026", "pageInfo": "e26228", "abstractText": "Fewer than 2% of eligible patients are screened for primary aldosteronism, despite evidence that early detection and targeted therapy are associated with lower cardiovascular and kidney morbidity. Recent updates to major hypertension and endocrine guidelines reflect growing recognition that primary aldosteronism is far more prevalent than previously understood and that broader, more practical screening approaches are needed. These recommendations increasingly extend screening beyond resistant hypertension to adults with stage 2 hypertension and even to all individuals with hypertension. They also aim to lower barriers to testing through more flexible guidance on antihypertensive medication management, reaffirm the aldosterone-to-renin ratio as the preferred initial test, and provide more standardized criteria for interpretation. Supporting evidence includes epidemiological data demonstrating a continuum of renin-independent aldosterone production across blood pressure categories, strong associations between untreated primary aldosteronism and adverse cardiovascular and kidney outcomes independent of blood pressure, and favorable cost-effectiveness of screening even in lower-risk groups. Implementation remains the principal challenge, with obstacles spanning patient, clinician, and health system levels. Emerging electronic health record strategies, including electronic phenotyping and integrated clinical decision support, have shown early promise in increasing screening uptake and streamlining diagnostic pathways. Collectively, contemporary guideline updates and implementation innovations represent a shift toward earlier and broader detection of primary aldosteronism, with the potential to reduce preventable cardiorenal disease across the hypertensive population.", "affiliation": "Department of Surgery (L.O., H.W.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.", "publicationStatus": "ppublish", "language": "eng", "pubModel": "Print-Electronic", "pubTypeList": { "pubType": [ "research-article", "Review", "Journal Article" ] }, "grantsList": { "grant": [ { "agency": "NCI NIH HHS", "acronym": "CA", "grantId": "K08 CA270385", "orderIn": 0 } ] }, "meshHeadingList": { "meshHeading": [ { "majorTopic_YN": "N", "descriptorName": "Humans" }, { "majorTopic_YN": "Y", "descriptorName": "Hypertension", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "DI", "qualifierName": "diagnosis" }, { "majorTopic_YN": "N", "abbreviation": "ET", "qualifierName": 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"availabilityCode": "S", "documentStyle": "doi", "site": "DOI", "url": "https://doi.org/10.1161/HYPERTENSIONAHA.125.26228" }, { "availability": "Free", "availabilityCode": "F", "documentStyle": "html", "site": "Europe_PMC", "url": "https://europepmc.org/articles/PMC12885222" }, { "availability": "Free", "availabilityCode": "F", "documentStyle": "pdf", "site": "Europe_PMC", "url": "https://europepmc.org/articles/PMC12885222?pdf=render" }, { "availability": "Free", "availabilityCode": "F", "documentStyle": "doi", "site": "DOI", "url": "https://doi.org/10.1161/hypertensionaha.125.26228" } ] }, "isOpenAccess": "N", "inEPMC": "Y", "inPMC": "Y", "citedByCount": 5, "hasReferences": "Y", "hasTextMinedTerms": "Y", "hasDbCrossReferences": "N", "hasPDF": "Y", "hasBook": "N", "hasSuppl": "N", "hasLabsLinks": "Y", "hasData": "Y", "authMan": "Y", "epmcAuthMan": "N", "nihAuthMan": "Y", "manuscriptId": "NIHMS2141797", "hasTMAccessionNumbers": "Y", "tmAccessionTypeList": { "accessionType": [ "doi" ] }, "dateOfCompletion": "2026-07-06", "dateOfCreation": "2026-02-06", "dateOfRevision": "2026-09-20", "electronicPublicationDate": "2026-02-06", "firstPublicationDate": "2026-02-06", "firstIndexDate": "2026-02-10", "fullTextReceivedDate": "2026-02-14", "hasEvaluations": "N" } ] }, "42697927": { "query": "EXT_ID:42697927 AND SRC:MED", "hit_count": 1, "records": [ { "id": "42697927", "source": "MED", "pmid": "42697927", "doi": "10.1038/s41371-026-01207-9", "title": "Using electronic clinical decision support in primary care to enhance identification of primary aldosteronism: a protocol for the CONSEP cluster-randomised controlled trial.", "authorString": "Russell G, Jia L, Stocks N, Nelson MR, Edwards J, Jensen G, Hunt E, Gwini SM, Akram M, Morris H, Skouteris H, Chen G, Sikaris KA, Stowasser M, Reid CM, Malios J, Wyatt D, Fuller PJ, Yang J.", "authorList": { "author": [ { "fullName": "Russell G", "lastName": "Russell", "firstName": "Grant", "initials": "G", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of General Practice, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia." } ] } }, { "fullName": "Jia L", "lastName": "Jia", "firstName": "Linghan", "initials": "L", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Centre for Endocrinology and Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia." } ] } }, { "fullName": "Stocks N", "lastName": "Stocks", "firstName": "Nigel", "initials": "N", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Discipline of General Practice, Adelaide Medical School, Adelaide University, Adelaide, SA, Australia." } ] } }, { "fullName": "Nelson MR", "lastName": "Nelson", "firstName": "Mark R", "initials": "MR", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia." } ] } }, { "fullName": "Edwards J", "lastName": "Edwards", "firstName": "Jessie", "initials": "J", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Discipline of General Practice, Adelaide Medical School, Adelaide University, Adelaide, SA, Australia." } ] } }, { "fullName": "Jensen G", "lastName": "Jensen", "firstName": "Grace", "initials": "G", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia." } ] } }, { "fullName": "Hunt E", "lastName": "Hunt", "firstName": "Emiko", "initials": "E", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of General Practice, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia." } ] } }, { "fullName": "Gwini SM", "lastName": "Gwini", "firstName": "Stella May", "initials": "SM", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Centre for Endocrinology and Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia." }, { "affiliation": "Monash Centre for Occupational and Environmental Health, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia." } ] } }, { "fullName": "Akram M", "lastName": "Akram", "firstName": "Muhammad", "initials": "M", "authorId": { "type": "ORCID", "value": "0000-0003-1073-3614" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Centre for Endocrinology and Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia." } ] } }, { "fullName": "Morris H", "lastName": "Morris", "firstName": "Heather", "initials": "H", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Health and Social Care Unit, School of Public Health and Preventative Medicine, Monash University, Melbourne, VIC, Australia." } ] } }, { "fullName": "Skouteris H", "lastName": "Skouteris", "firstName": "Helen", "initials": "H", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Health and Social Care Unit, School of Public Health and Preventative Medicine, Monash University, Melbourne, VIC, Australia." } ] } }, { "fullName": "Chen G", "lastName": "Chen", "firstName": "Gang", "initials": "G", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Centre for Health Policy, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia." } ] } }, { "fullName": "Sikaris KA", "lastName": "Sikaris", "firstName": "Kenneth A", "initials": "KA", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Healius Pathology, Sydney, NSW, Australia." }, { "affiliation": "Department of Pathology, University of Melbourne, Melbourne, VIC, Australia." } ] } }, { "fullName": "Stowasser M", "lastName": "Stowasser", "firstName": "Michael", "initials": "M", "authorId": { "type": "ORCID", "value": "0000-0002-4317-8584" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Endocrine Hypertension Research Centre, University of Queensland Frazer Institute, Princess Alexandra Hospital, Brisbane, QLD, Australia." } ] } }, { "fullName": "Reid CM", "lastName": "Reid", "firstName": "Christopher M", "initials": "CM", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Curtin School of Population Health, Faculty of Health Sciences, Curtin University, Bentley, WA, Australia." }, { "affiliation": "Department of Epidemiology, School of Public Health and Preventive Medicine, Monash University, Clayton, VIC, Australia." } ] } }, { "fullName": "Malios J", "lastName": "Malios", "firstName": "John", "initials": "J", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Primary Aldosteronism Centre of Excellence Consumer Council, Hudson Institute of Medical Research, Clayton, VIC, Australia." } ] } }, { "fullName": "Wyatt D", "lastName": "Wyatt", "firstName": "David", "initials": "D", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Primary Aldosteronism Centre of Excellence Consumer Council, Hudson Institute of Medical Research, Clayton, VIC, Australia." } ] } }, { "fullName": "Fuller PJ", "lastName": "Fuller", "firstName": "Peter J", "initials": "PJ", "authorId": { "type": "ORCID", "value": "0000-0002-0948-2072" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Centre for Endocrinology and Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia." }, { "affiliation": "Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia." } ] } }, { "fullName": "Yang J", "lastName": "Yang", "firstName": "Jun", "initials": "J", "authorId": { "type": "ORCID", "value": "0000-0003-4620-4976" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Centre for Endocrinology and Reproductive Health, Hudson Institute of Medical Research, Clayton, VIC, Australia. Jun.Yang@hudson.org.au." }, { "affiliation": "Department of Molecular and Translational Science, Monash University, Clayton, VIC, Australia. Jun.Yang@hudson.org.au." }, { "affiliation": "Department of Medicine, Monash University, Clayton, VIC, Australia. Jun.Yang@hudson.org.au." } ] } } ] }, "authorIdList": { "authorId": [ { "type": "ORCID", "value": "0000-0002-0948-2072" }, { "type": "ORCID", "value": "0000-0002-4317-8584" }, { "type": "ORCID", "value": "0000-0003-1073-3614" }, { "type": "ORCID", "value": "0000-0003-4620-4976" } ] }, "journalInfo": { "journalIssueId": 4253849, "dateOfPublication": "2026 Sep", "monthOfPublication": 9, "yearOfPublication": 2026, "journal": { "medlineAbbreviation": "J Hum Hypertens", "title": "Journal of human hypertension", "essn": "1476-5527", "issn": "0950-9240", "isoabbreviation": "J Hum Hypertens", "nlmid": "8811625" }, "printPublicationDate": "2026-09-01" }, "pubYear": "2026", "abstractText": "Primary aldosteronism (PA) is a common and treatable cause of hypertension, affecting up to 15% of patients in primary care, yet it remains substantially underdiagnosed. Recent international guidelines recommend routine screening for PA in all individuals with hypertension, highlighting the need for effective implementation strategies in general practice. We aim to determine whether an electronic clinical decision support (eCDS) tool integrated into general practice software improves PA screening and diagnosis. CONSEP (CONn Syndrome screening and Evaluation in Primary care) is a pragmatic cluster randomised controlled trial conducted in general practices across three Australian states. Practices will be block-randomised by size and location (state) in a 1:1 ratio to intervention (eCDS) or control. Patients eligible for analysis will be adults with hypertension attending participating practices. De-identified data will be extracted from clinical software at baseline, 12 months, and 24 months. Analyses will follow intention-to-treat principles using regression models accounting for clustering at the practice level. Primary outcomes are the proportion of patients screened for PA within 12 months and the proportion diagnosed with PA within 24 months. Secondary outcomes include blood pressure control, antihypertensive medication burden, cost-effectiveness, and a process evaluation assessing acceptability, feasibility, and sustainability. By embedding guideline-based screening into routine workflows, this trial addresses a major evidence-practice gap in hypertension care. If effective, the intervention could improve hypertension management, increase detection of PA, and reduce long-term cardiovascular risk in primary care.", "affiliation": "Department of General Practice, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.", "publicationStatus": "aheadofprint", "language": "eng", "pubModel": "Print-Electronic", "pubTypeList": { "pubType": [ "Journal Article" ] }, "grantsList": { "grant": [ { "agency": "Department of Health, Australian Government", "grantId": "MRFF2022933", "orderIn": 0 }, { "agency": "Department of Health | National Health and Medical Research Council", "grantId": "APP2041474", "orderIn": 0 }, { "agency": "Department of Health | National Health and Medical Research Council (NHMRC)", "grantId": "APP2041474", "orderIn": 0 }, { "agency": "Department of Health, Australian Government (Department of Health)", "grantId": "MRFF2022933", "orderIn": 0 } ] 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"fullTextIdList": { "fullTextId": [ "PMC13599880" ] }, "doi": "10.1136/bmjopen-2026-122192", "title": "Intensification of blood pressure lowering therapeutics based on diuretics versus usual management for uncontrolled hypertension in patients with moderate to severe chronic kidney disease (THINK): protocol for an open label, two-parallel group, cluster randomised controlled, superiority, phase 3 trial.", "authorString": "Le Vilain-Abraham F, Halimi JM, Rossignol P, Laville M, Azizi M, Stengel B, Maisons V, Rouz\u00e8s A, Caille A, Sautenet B.", "authorList": { "author": [ { "fullName": "Le Vilain-Abraham F", "lastName": "Le Vilain-Abraham", "firstName": "Floriane", "initials": "F", "authorId": { "type": "ORCID", "value": "0000-0002-5601-0246" }, "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Universit\u00e9 de Tours, Universit\u00e9 de Nantes, INSERM, SPHERE U1246, Tours, France floriane.levilainabraham@univ-tours.fr." }, { "affiliation": "INSERM CIC1415, CHRU de Tours, Tours, France." } ] } }, { "fullName": "Halimi JM", "lastName": "Halimi", "firstName": "Jean-Michel", "initials": "JM", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Unit\u00e9 INSERM 1327 Ischemia, Universit\u00e9 de Tours, Tours, France." }, { "affiliation": "Service de N\u00e9phrologie-Hypertension, Dialyse, Transplantation r\u00e9nale, CHU de Tours, Tours, France." }, { "affiliation": "F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Universit\u00e9 de Lorraine, Inserm, Centre d'Investigations Cliniques, Plurith\u00e9matique 14-33, Inserm U1116, Nancy, France." } ] } }, { "fullName": "Rossignol P", "lastName": "Rossignol", "firstName": "Patrick", "initials": "P", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Universit\u00e9 de Lorraine, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre d'Investigations Cliniques-Plurith\u00e9matique 1433, INSERM Unit 1116, Centre Hospitalier R\u00e9gional Universitaire (CHRU) de Nancy, and French Clinical Research Infrastructure Network Investigator Network initiative Cardiovascular and Renal Clinical Trialists (F-CRIN INI-CRCT), Nancy, France." }, { "affiliation": "Medical specialties and nephrology departments, Princess Grace Hospital, and Monaco Private Hemodialysis Centre, Monaco, and Monaco Clinical Research Infrastructure Network (M-CRIN), Mocaco, (P.R.)." } ] } }, { "fullName": "Laville M", "lastName": "Laville", "firstName": "Maurice", "initials": "M", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Department of Nephrology and Renal Nutrition, Hospital Edouard Herriot, Lyon, France." } ] } }, { "fullName": "Azizi M", "lastName": "Azizi", "firstName": "Michel", "initials": "M", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Universit\u00e9 Paris Cit\u00e9, INSERM Centre d'Investigation Clinique 1418, Paris, France." }, { "affiliation": "Assistance Publique-H\u00f4pitaux de Paris, Department of Hypertension, H\u00f4pital Europ\u00e9en Georges Pompidou, Paris, France." } ] } }, { "fullName": "Stengel B", "lastName": "Stengel", "firstName": "B\u00e9n\u00e9dicte", "initials": "B", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Center for Research in Epidemiology and Population Health (CESP), Clinical Epidemiology and Pharmacoepidemiology Team, Inserm, Paris-Saclay University, Versailles Saint-Quentin-en-Yvelines University, Villejuif, France." } ] } }, { "fullName": "Maisons V", "lastName": "Maisons", "firstName": "Valentin", "initials": "V", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Universit\u00e9 de Tours, Universit\u00e9 de Nantes, INSERM, SPHERE U1246, Tours, France." }, { "affiliation": "Service de N\u00e9phrologie-Hypertension, Dialyse, Transplantation r\u00e9nale, CHU de Tours, Tours, France." }, { "affiliation": "F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Universit\u00e9 de Lorraine, Inserm, Centre d'Investigations Cliniques, Plurith\u00e9matique 14-33, Inserm U1116, Nancy, France." } ] } }, { "fullName": "Rouz\u00e8s A", "lastName": "Rouz\u00e8s", "firstName": "Agn\u00e8s", "initials": "A", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "CHRU Tours, Service de Pharmacosurveillance, Centre R\u00e9gional de Pharmacovigilance, Tours, France." } ] } }, { "fullName": "Caille A", "lastName": "Caille", "firstName": "Agn\u00e8s", "initials": "A", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Universit\u00e9 de Tours, Universit\u00e9 de Nantes, INSERM, SPHERE U1246, Tours, France." }, { "affiliation": "INSERM CIC1415, CHRU de Tours, Tours, France." } ] } }, { "fullName": "Sautenet B", "lastName": "Sautenet", "firstName": "B\u00e9n\u00e9dicte", "initials": "B", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Universit\u00e9 de Tours, Universit\u00e9 de Nantes, INSERM, SPHERE U1246, Tours, France." }, { "affiliation": "Service de N\u00e9phrologie-Hypertension, Dialyse, Transplantation r\u00e9nale, CHU de Tours, Tours, France." }, { "affiliation": "F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Universit\u00e9 de Lorraine, Inserm, Centre d'Investigations Cliniques, Plurith\u00e9matique 14-33, Inserm U1116, Nancy, France." } ] } } ] }, "authorIdList": { "authorId": [ { "type": "ORCID", "value": "0000-0002-5601-0246" } ] }, "dataLinksTagsList": { "dataLinkstag": [ "supporting_data" ] }, "journalInfo": { "issue": "9", "volume": "16", "journalIssueId": 4252509, "dateOfPublication": "2026 Sep", "monthOfPublication": 9, "yearOfPublication": 2026, "journal": { "medlineAbbreviation": "BMJ Open", "title": "BMJ open", "essn": "2044-6055", "issn": "2044-6055", "isoabbreviation": "BMJ Open", "nlmid": "101552874" }, "printPublicationDate": "2026-09-01" }, "pubYear": "2026", "pageInfo": "e122192", "abstractText": "

Introduction

Hypertension is the primary modifiable risk factor for cardiorenal complications of chronic kidney disease (CKD). It is well established that lowering blood pressure (BP) in patients with CKD reduces renal and cardiovascular complications. The guidelines advise starting the BP-lowering drug with ACE inhibitors (ACEi) or angiotensin receptor blockers (ARB), but then there is no strong evidence to support the preferential use of any particular agent in controlling BP. Our hypothesis is that patients with CKD and uncontrolled hypertension are fluid overloaded and that the second line of treatment after an ACEi or an ARB should be a diuretic.

Methods and analysis

This is a two-parallel group cluster randomised superiority phase 3 trial comparing a specific algorithm to lower BP in patients with moderate to severe CKD based on diuretics to standard of care. The primary endpoint is a composite time-to-event endpoint of (1) kidney failure with replacement therapy (KFRT), (2) estimated glomerular filtration rate decline \u226540%, (3) cardiovascular events (myocardial infarction, heart failure hospitalisation, stroke) and (4) all-cause mortality. Secondary endpoints include each component of the primary endpoint, systolic and diastolic BP at 3 months and 6 months post baseline then every 6 months, proportion of patients with controlled BP at 2 years, change from baseline in glomerular filtration rate and in proteinuria (g/day) or proteinuria/creatininuria (g/g) at 3 months and 6 months post baseline then every 6 months, proportion of patients who used at least one diuretic, quality of life and safety. It is planned to include 720 patients in 40 centres.

Ethics and dissemination

This study was approved by the Ethics Committee CPP Ile-de-France VII on 23 January 2023 (ref: 2022-5\u200901\u2009494-39-00). Study findings will be published in a peer-reviewed journal and presented at scientific conferences.

Trial registration number

NCT05732727.", "affiliation": "Universit\u00e9 de Tours, Universit\u00e9 de Nantes, INSERM, SPHERE U1246, Tours, France floriane.levilainabraham@univ-tours.fr.", "publicationStatus": "epublish", "language": "eng", "pubModel": "Electronic", "pubTypeList": { "pubType": [ "Clinical Trial Protocol", "research-article", "Journal Article" ] }, "meshHeadingList": { "meshHeading": [ { "majorTopic_YN": "N", "descriptorName": "Humans" }, { "majorTopic_YN": "Y", "descriptorName": "Hypertension", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "CO", "qualifierName": "complications" }, { "majorTopic_YN": "N", "abbreviation": "DT", "qualifierName": "drug therapy" } ] } }, { "majorTopic_YN": "Y", "descriptorName": "Antihypertensive Agents", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "TU", "qualifierName": "therapeutic use" } ] } }, { "majorTopic_YN": "Y", "descriptorName": "Diuretics", "meshQualifierList": { "meshQualifier": [ { 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University, Clayton, Australia." }, { "affiliation": "Department of Pharmacology, Cardiovascular Disease Program, Biomedicine Discovery Institute, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Australia." } ] } }, { "fullName": "Snelson M", "lastName": "Snelson", "firstName": "Matthew", "initials": "M", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension Research Laboratory, Victorian Heart Institute, Monash University, Clayton, Australia." }, { "affiliation": "Department of Pharmacology, Cardiovascular Disease Program, Biomedicine Discovery Institute, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Australia." }, { "affiliation": "Nutrition & Health Innovation Research Institute, Edith Cowan University, Perth, Australia." } ] } }, { "fullName": "Rim D", "lastName": "Rim", "firstName": "Donggyu", "initials": "D", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": 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"initials": "PTT", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension Research Laboratory, Victorian Heart Institute, Monash University, Clayton, Australia." }, { "affiliation": "Department of Pharmacology, Cardiovascular Disease Program, Biomedicine Discovery Institute, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Australia." } ] } }, { "fullName": "Pase MP", "lastName": "Pase", "firstName": "Matthew P", "initials": "MP", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "School of Psychological Science, Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia." } ] } }, { "fullName": "McCaffrey T", "lastName": "McCaffrey", "firstName": "Tracy", "initials": "T", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Digital Nutrition Lab, Department of Nutrition, Dietetics and Food, Monash University, Melbourne, Australia." }, { "affiliation": "Victorian Heart Institute, Monash University, Clayton, Australia." } ] } }, { "fullName": "Ha FJ", "lastName": "Ha", "firstName": "Francis J", "initials": "FJ", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Victorian Heart Hospital, Melbourne, Australia." } ] } }, { "fullName": "Dhital S", "lastName": "Dhital", "firstName": "Sushil", "initials": "S", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Food Engineering and Nutrition Lab, Department of Chemical Engineering, Monash University, Melbourne, Australia." } ] } }, { "fullName": "Davis E", "lastName": "Davis", "firstName": "Esther", "initials": "E", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Victorian Heart Hospital, Melbourne, Australia." } ] } }, { "fullName": "Lambert E", "lastName": "Lambert", "firstName": "Elisabeth", "initials": "E", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "School of Health Science and Iverson Health Innovation Research Institute, Swinburne University of Technology, Melbourne, Australia." } ] } }, { "fullName": "Macefield VG", "lastName": "Macefield", "firstName": "Vaughan G", "initials": "VG", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Human Neurophysiology Lab, Department of Neuroscience, Monash University, Melbourne, Australia." } ] } }, { "fullName": "Marques FZ", "lastName": "Marques", "firstName": "Francine Z", "initials": "FZ", "authorAffiliationDetailsList": { "authorAffiliation": [ { "affiliation": "Hypertension Research Laboratory, Victorian Heart Institute, Monash University, Clayton, Australia." }, { "affiliation": "Department of Pharmacology, Cardiovascular Disease Program, Biomedicine Discovery Institute, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Australia." }, { "affiliation": "Baker Heart and Diabetes Institute, Melbourne, Australia." } ] } }, { "fullName": "R Muralitharan R", 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Background

Hypertension affects 1 in 3 Australian adults and is a major contributor to stroke and myocardial infarction. Despite the availability of various medications, over 50% of patients struggle to control their blood pressure (BP) due to nonadherence, difficulty finding the right treatment, or avoidance of medication. Diet plays a key role in cardiovascular health, with high-fiber intake shown to lower BP through the production of short-chain fatty acids (SCFAs), metabolites formed during fiber fermentation. A previous clinical trial found that incorporating a specific type of resistant starch - high amylose maize starch enriched with acetate and butyrate (HAMSA/B) - significantly reduced blood pressure in hypertensive patients. While the exact mechanism remains unclear, SCFAs may influence BP via the gut-brain axis by reducing muscle sympathetic nerve activity (MSNA), which has vasoconstrictor function and is elevated in hypertensive individuals.

Methods

The GRAINS-BP clinical trial will recruit 29 adults with untreated hypertension (\u2265\u2009140/90 mmHg) for a double-blind, cross-over study using HAMSA/B administered as a shake delivered twice daily. The assessment period will span 48\u00a0days and include four visits at the Alfred Hospital, Melbourne, Australia. At visit 1, baseline measurement will be taken, including muscle sympathetic nerve activity (MSNA) and electrocardiogram (ECG). Participants will be randomised to the order in which they receive the placebo and HAMSA/B shake. Each intervention period will last 14\u00a0days, separated by a 20-day washout before participants cross over to the alternate treatment. At each visit, faecal, urine, and blood samples will be collected to investigate microbiome, cardiometabolic, renal, and immune profiles, respectively. Univariate and multivariate statistical analyses will be conducted to examine treatment effects and to identify correlations among microbiome, cardiometabolic, renal, and immune outcomes.

Discussion

This project's primary outcome is change in autonomic nervous system activity. Secondary outcomes include 24-h BP, gut microbiome composition, SCFA levels, immune cell profiles gastrointestinal transit time, quality of life, anxiety and depression symptoms, cognitive function, gut barrier integrity, and circulating micro- and nanoplastics. Findings from this study will reveal whether SCFAs reduce blood pressure by their influence on the autonomic nervous system.

Trial registration

This trial is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12625000557437).", "affiliation": "Hypertension Research Laboratory, Victorian Heart Institute, Monash University, Clayton, Australia.", "publicationStatus": "epublish", "language": "eng", "pubModel": "Electronic", "pubTypeList": { "pubType": [ "research-article", "Randomized Controlled Trial", "Journal Article" ] }, "meshHeadingList": { "meshHeading": [ { "majorTopic_YN": "Y", "descriptorName": "Intestines", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "IR", "qualifierName": "innervation" } ] } }, { "majorTopic_YN": "Y", "descriptorName": "Sympathetic Nervous System", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "PP", "qualifierName": "physiopathology" } ] } }, { "majorTopic_YN": "N", "descriptorName": "Humans" }, { "majorTopic_YN": "Y", "descriptorName": "Hypertension", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "DI", "qualifierName": "diagnosis" }, { "majorTopic_YN": "N", "abbreviation": "DH", "qualifierName": "diet therapy" }, { "majorTopic_YN": "N", "abbreviation": "MI", "qualifierName": "microbiology" }, { "majorTopic_YN": "N", "abbreviation": "PP", "qualifierName": "physiopathology" } ] } }, { "majorTopic_YN": "N", "descriptorName": "Fatty Acids, Volatile", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "ME", "qualifierName": "metabolism" } ] } }, { "majorTopic_YN": "N", "descriptorName": "Treatment Outcome" }, { "majorTopic_YN": "N", "descriptorName": "Cross-Over Studies" }, { "majorTopic_YN": "N", "descriptorName": "Double-Blind Method" }, { "majorTopic_YN": "N", "descriptorName": "Signal Transduction" }, { "majorTopic_YN": "Y", "descriptorName": "Blood Pressure" }, { "majorTopic_YN": "N", "descriptorName": "Research Design" }, { "majorTopic_YN": "N", "descriptorName": "Time Factors" }, { "majorTopic_YN": "Y", "descriptorName": "Dietary Fiber", "meshQualifierList": { "meshQualifier": [ { "majorTopic_YN": "N", "abbreviation": "AD", "qualifierName": "administration & dosage" } ] } }, { "majorTopic_YN": "N", "descriptorName": "Victoria" } ] }, "keywordList": { "keyword": [ "Hypertension", "Diet", "Fibre", "Randomised Controlled Trial", "Sympathetic Nerve Activity", "Short-chain Fatty Acids", "Gut Microbiome", "Gut-brain Axis", "Resistant Starches" ] }, "chemicalList": { "chemical": [ { "name": "Fatty Acids, Volatile", "registryNumber": "0" }, { "name": "Dietary Fiber", "registryNumber": "0" } ] }, "subsetList": { "subset": [ { "code": "IM", "name": "Index Medicus" } ] }, "fullTextUrlList": { "fullTextUrl": [ { "availability": "Subscription required", "availabilityCode": "S", "documentStyle": "doi", "site": "DOI", "url": "https://doi.org/10.1186/s13063-026-09911-0" }, { "availability": "Open access", "availabilityCode": "OA", "documentStyle": "html", "site": "Europe_PMC", "url": "https://europepmc.org/articles/PMC13679180" }, { "availability": "Open access", "availabilityCode": "OA", "documentStyle": "pdf", "site": "Europe_PMC", "url": "https://europepmc.org/articles/PMC13679180?pdf=render" } ] }, "commentCorrectionList": { "commentCorrection": [ { "source": "PPR", "id": "PPR1262194", "type": "Preprint in", "note": "Link created based on a title-first author match", "orderIn": 10002 } ] }, "isOpenAccess": "Y", "inEPMC": "Y", "inPMC": "Y", "citedByCount": 0, "hasReferences": "Y", "hasTextMinedTerms": "Y", "hasDbCrossReferences": "N", "hasPDF": "Y", "hasBook": "N", "hasSuppl": "Y", "hasLabsLinks": "N", "hasData": "Y", "license": "cc by-nc-nd", "authMan": "N", "epmcAuthMan": "N", "nihAuthMan": "N", "hasTMAccessionNumbers": "N", "dateOfCompletion": "2026-10-19", "dateOfCreation": "2026-10-19", "dateOfRevision": "2026-10-22", "electronicPublicationDate": "2026-07-22", "firstPublicationDate": "2026-07-22", "firstIndexDate": "2026-10-21", "fullTextReceivedDate": "2026-10-21", "hasEvaluations": "N" } ] } }, "publisher_fulltext_checks": { "42921236-fulltext.xml": { "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13693583/fullTextXML", "resolved_url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13693583/fullTextXML", "status": 200, "bytes": 110685 }, "41645899-fulltext.xml": { "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12885222/?report=xml", "resolved_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12885222/?report=xml", "status": 200, "bytes": 190827 }, "42909506-publisher.html": { "url": "https://doi.org/10.1097/HJH.0000000000004451", "resolved_url": "https://www.ovid.com/jnls/jhypertension/fulltext/10.1097/hjh.0000000000004451~2026-international-society-of-hypertension-global", "status": 200, "bytes": 1463549 }, "42926177-publisher.html": { "url": "https://doi.org/10.1016/j.jfma.2026.09.040", "resolved_url": "https://linkinghub.elsevier.com/retrieve/pii/S0929664626009253", "status": 200, "bytes": 2971 }, 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"requested_url": "https://doi.org/10.5334/gh.1595.s1", "resolved_url": "https://storage.googleapis.com/jnl-up-j-gh-files/journals/1/articles/1595/6ad88b6daaa8f.pdf", "http_status": 200, "checked": "Text extracted and entire one-page table rendered and visually inspected. BP controlled defined by last visit in preceding three months." } }, "sources_queried": [ "PubMed E-utilities esearch and efetch", "CDSR via PubMed: 18 per-topic publication-date queries plus whole-journal publication- and Entrez-date queries", "Europe PMC REST search: 18 topics plus 17 record-specific follow-ups; fullTextXML where available", "ClinicalTrials.gov v2: all 64 previously cited identifiers plus four query.term searches", "Crossref works: all nine additions and 17 prior-sweep records, plus two other follow-ups; no mailto", "NICE NG136; WHO hypertension fact sheet; ISH guideline resource page and announcement; Blood Pressure UK news; WHL homepage", "EU Clinical Trials Register: THINK hypertension query returned one unrelated study", "Official CTIS query attempted, JavaScript shell only; WHO ICTRP and ANZCTR queries attempted, HTTP 403; ISRCTN query redirected to holding page; CTRI search page retrieved, CAPTCHA prevents completed search", "ISH global guideline publisher full text; GUARDD-US PGx and Bangladesh HEARTS full texts; Owei full text; THINK and GRAINS-BP protocol full texts; Bangladesh supplementary Table S1 PDF" ], "sources_not_searched": { "CENTRAL": "Cochrane Library HTTP 403; CDSR searched only through PubMed.", "SciELO": "Search HTTP 403.", "LILACS": "Search HTTP 403.", "WHO ICTRP, ANZCTR": "Query attempts returned HTTP 403; no registry search results obtained.", "CTIS": "Official query returned JS shell; no official trial result rendered.", "ISRCTN": "Search request redirected to holding page; no result set.", "CTRI": "Search page requires security code; no completed database query.", "ChiCTR": "Not queried.", "Unpaywall": "Skipped; LIFEBANK_CONTACT_EMAIL unset. No personal contact address used.", "Embase, Scopus, Web of Science": "No access; not searched." }, "source_evidence": { "42909506": { "fulltext_url": "https://www.ovid.com/jnls/jhypertension/fulltext/10.1097/hjh.0000000000004451~2026-international-society-of-hypertension-global", "sections": [ "Table 2 revisions 2\u20135", "Table 3 classification", "Section 7.2 treatment strategy", "Section 10.2 secondary hypertension" ], "verbatim_excerpt": "sHBPM is recommended as the main method for hypertension diagnosis and management", "table_values": { "Table 2 revision 5": "Optimal target <130/80 mm Hg; confirmed elevated office BP 130\u2013139/80\u201389", "Table 3": "Hypertension begins at office systolic 140 or diastolic 90 mm Hg" }, "section_values": { "7.2": "Essential <140/90; optimal <130/80; individualise with frailty, symptomatic orthostatic hypotension or limited life expectancy" }, "interpretation_limit": "Consensus adaptation of recent guidelines, not a new randomised trial. Specific drug approval statements were not transferred." }, "42894271": { "fulltext_url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13677980/fullTextXML", "sections": [ "Table 1", "Table 2", "Results", "Figure 2" ], "verbatim_excerpt": "At 6 months, there was no difference in SBP reduction between groups.", "table_values": { "Table 1 randomized": "953 immediate, 921 delayed; total 1874", "Table 2": "No significant whole-cohort systolic difference at three or six months" }, "interpretation_limit": "Candidate-gene return-of-results decision support, not PRS-directed allocation. Three-month subgroup signals did not persist at six months. Abstract and body adjusted estimates differ slightly; no adjusted numeric estimate was copied." }, "42921236": { "fulltext_url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13693583/fullTextXML", "sections": [ "Table 2", "Table 3", "Phase 3 narrative", "Figure 8", "Supplementary Table S1" ], "verbatim_excerpt": "Patients with BP <140/90 at their last visit in the last three months", "table_values": { "Table 2": "320 activated facilities in phase ending May 2026", "Table 3": "37% July 2020 to 59% April 2026" }, "source_discrepancy": "Narrative/Figure 8 place 59% in May 2026; Table 3 says April. Enrolment dates and abstract population-coverage arithmetic also disagree; these were not copied.", "interpretation_limit": "Programme monitoring among enrolled patients; not national survey prevalence/control and not a causal comparison." }, "41645899": { "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12885222/?report=xml", "sections": [ "Table 1", "Overview of contemporary guidelines", "Economic considerations" ], "verbatim_excerpt": "Class IIa (should be considered): Screen all adults with confirmed HTN", "interpretation_limit": "This is a full-text comparative review. Primary ESC guideline full-text request was blocked; the wiki attributes the comparison to Owei and does not infer identical recommendations across guidelines." }, "42754276": { "fulltext_url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13599880/fullTextXML", "section": "Ethics and dissemination", "eu_trial_number": "2022-501494-39-00", "interpretation_limit": "Identifier comes from protocol; official CTIS registry record not independently rendered." } }, "triage": { "bibliography_only": [ "42925856", "42902709" ], "new_guideline_or_guidance_documents": [ "42909506", "42926177", "42853222", "42907045" ], "fulltext_based_synthesis": [ "42909506", "42894271", "42921236", "41645899" ], "no_new_cochrane_review": "All 18 per-topic CDSR queries returned zero in PubMed; five whole-journal records were off-topic.", "no_doi_only_additions": true, "not_added_examples": { "42905977": "Baxdrostat albuminuria record has no abstract; full report not retrieved; chase full text before extracting effects.", "42894232": "GRAINS-BP is a protocol, not a new trial result; 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all added journal citations independently resolved through E-utilities and Crossref. Official registry queries/limits and primary-document retrievals are recorded separately." }