{
  "condition": "generalized-anxiety-disorder",
  "sweep_date": "2026-10-24",
  "author": "Codex",
  "window": {
    "date_from": "2026-10-17",
    "date_to": "2026-10-24",
    "primary": "pdat",
    "supplement": "edat broad and instruments"
  },
  "pubmed": [
    {
      "topic": "overview",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")",
      "datetype": "pdat",
      "count": "15",
      "retmax": "15",
      "retstart": "0",
      "idlist": [
        "42906357",
        "42905249",
        "42904642",
        "42903361",
        "42901722",
        "42901716",
        "42900650",
        "42898441",
        "42897714",
        "42896481",
        "42896217",
        "42896155",
        "42895653",
        "28520380",
        "42575363"
      ],
      "translationset": [],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "overview",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "diagnosis-boundary",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (diagnos* OR classification OR criteria OR excessiveness OR uncontrollab* OR taxometric*)",
      "datetype": "pdat",
      "count": "6",
      "retmax": "6",
      "retstart": "0",
      "idlist": [
        "42905249",
        "42904642",
        "42900650",
        "42898441",
        "42895653",
        "42575363"
      ],
      "translationset": [
        {
          "from": "classification",
          "to": "\"classification\"[MeSH Terms] OR \"classification\"[All Fields] OR \"classifications\"[All Fields] OR \"classification\"[Subheading] OR \"classification's\"[All Fields] OR \"classificator\"[All Fields] OR \"classificators\"[All Fields]"
        },
        {
          "from": "criteria",
          "to": "\"criteria's\"[All Fields] OR \"criterias\"[All Fields] OR \"standards\"[Subheading] OR \"standards\"[All Fields] OR \"criteria\"[All Fields]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"diagnos*\"[All Fields] OR (\"classification\"[MeSH Terms] OR \"classification\"[All Fields] OR \"classifications\"[All Fields] OR \"classification\"[MeSH Subheading] OR \"classification s\"[All Fields] OR \"classificator\"[All Fields] OR \"classificators\"[All Fields]) OR (\"criteria s\"[All Fields] OR \"criterias\"[All Fields] OR \"standards\"[MeSH Subheading] OR \"standards\"[All Fields] OR \"criteria\"[All Fields]) OR \"excessiveness\"[All Fields] OR \"uncontrollab*\"[All Fields] OR \"taxometric*\"[All Fields]) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "diagnosis-boundary",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (diagnos* OR classification OR criteria OR excessiveness OR uncontrollab* OR taxometric*) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "classification",
          "to": "\"classification\"[MeSH Terms] OR \"classification\"[All Fields] OR \"classifications\"[All Fields] OR \"classification\"[Subheading] OR \"classification's\"[All Fields] OR \"classificator\"[All Fields] OR \"classificators\"[All Fields]"
        },
        {
          "from": "criteria",
          "to": "\"criteria's\"[All Fields] OR \"criterias\"[All Fields] OR \"standards\"[Subheading] OR \"standards\"[All Fields] OR \"criteria\"[All Fields]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"diagnos*\"[All Fields] OR (\"classification\"[MeSH Terms] OR \"classification\"[All Fields] OR \"classifications\"[All Fields] OR \"classification\"[MeSH Subheading] OR \"classification s\"[All Fields] OR \"classificator\"[All Fields] OR \"classificators\"[All Fields]) OR (\"criteria s\"[All Fields] OR \"criterias\"[All Fields] OR \"standards\"[MeSH Subheading] OR \"standards\"[All Fields] OR \"criteria\"[All Fields]) OR \"excessiveness\"[All Fields] OR \"uncontrollab*\"[All Fields] OR \"taxometric*\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "epidemiology-burden",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (prevalence OR incidence OR epidemiolog* OR burden OR mortality OR \"treatment gap\")",
      "datetype": "pdat",
      "count": "7",
      "retmax": "7",
      "retstart": "0",
      "idlist": [
        "42904642",
        "42903361",
        "42901722",
        "42897714",
        "42896481",
        "42896217",
        "42895653"
      ],
      "translationset": [
        {
          "from": "prevalence",
          "to": "\"epidemiology\"[Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence's\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields]"
        },
        {
          "from": "incidence",
          "to": "\"epidemiology\"[Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]"
        },
        {
          "from": "burden",
          "to": "\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]"
        },
        {
          "from": "mortality",
          "to": "\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[Subheading]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR \"epidemiolog*\"[All Fields] OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading]) OR \"treatment gap\"[All Fields]) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "epidemiology-burden",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (prevalence OR incidence OR epidemiolog* OR burden OR mortality OR \"treatment gap\") AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "prevalence",
          "to": "\"epidemiology\"[Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence's\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields]"
        },
        {
          "from": "incidence",
          "to": "\"epidemiology\"[Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]"
        },
        {
          "from": "burden",
          "to": "\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]"
        },
        {
          "from": "mortality",
          "to": "\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[Subheading]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR \"epidemiolog*\"[All Fields] OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading]) OR \"treatment gap\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "mechanism",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (worry OR \"intolerance of uncertainty\" OR neuroimag* OR genetic* OR biomarker* OR inflammation OR pathophysiology)",
      "datetype": "pdat",
      "count": "5",
      "retmax": "5",
      "retstart": "0",
      "idlist": [
        "42904642",
        "42901716",
        "42898441",
        "42895653",
        "28520380"
      ],
      "translationset": [
        {
          "from": "worry",
          "to": "\"worried\"[All Fields] OR \"worries\"[All Fields] OR \"worry\"[All Fields] OR \"worrying\"[All Fields]"
        },
        {
          "from": "inflammation",
          "to": "\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation's\"[All Fields]"
        },
        {
          "from": "pathophysiology",
          "to": "\"pathophysiologies\"[All Fields] OR \"physiopathology\"[Subheading] OR \"physiopathology\"[All Fields] OR \"pathophysiology\"[All Fields]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"worried\"[All Fields] OR \"worries\"[All Fields] OR \"worry\"[All Fields] OR \"worrying\"[All Fields] OR \"intolerance of uncertainty\"[All Fields] OR \"neuroimag*\"[All Fields] OR \"genetic*\"[All Fields] OR \"biomarker*\"[All Fields] OR (\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation s\"[All Fields]) OR (\"pathophysiologies\"[All Fields] OR \"physiopathology\"[MeSH Subheading] OR \"physiopathology\"[All Fields] OR \"pathophysiology\"[All Fields])) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "mechanism",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (worry OR \"intolerance of uncertainty\" OR neuroimag* OR genetic* OR biomarker* OR inflammation OR pathophysiology) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "worry",
          "to": "\"worried\"[All Fields] OR \"worries\"[All Fields] OR \"worry\"[All Fields] OR \"worrying\"[All Fields]"
        },
        {
          "from": "inflammation",
          "to": "\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation's\"[All Fields]"
        },
        {
          "from": "pathophysiology",
          "to": "\"pathophysiologies\"[All Fields] OR \"physiopathology\"[Subheading] OR \"physiopathology\"[All Fields] OR \"pathophysiology\"[All Fields]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"worried\"[All Fields] OR \"worries\"[All Fields] OR \"worry\"[All Fields] OR \"worrying\"[All Fields] OR \"intolerance of uncertainty\"[All Fields] OR \"neuroimag*\"[All Fields] OR \"genetic*\"[All Fields] OR \"biomarker*\"[All Fields] OR (\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation s\"[All Fields]) OR (\"pathophysiologies\"[All Fields] OR \"physiopathology\"[MeSH Subheading] OR \"physiopathology\"[All Fields] OR \"pathophysiology\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "screening-measurement",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (screen* OR psychometric* OR \"GAD-7\" OR \"GAD-2\" OR \"HAM-A\" OR \"Hamilton Anxiety\" OR \"Penn State Worry\")",
      "datetype": "pdat",
      "count": "9",
      "retmax": "9",
      "retstart": "0",
      "idlist": [
        "42905249",
        "42903361",
        "42901722",
        "42900650",
        "42898441",
        "42896481",
        "42896217",
        "42896155",
        "42895653"
      ],
      "translationset": [],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"screen*\"[All Fields] OR \"psychometric*\"[All Fields] OR \"GAD-7\"[All Fields] OR \"GAD-2\"[All Fields] OR \"HAM-A\"[All Fields] OR \"Hamilton Anxiety\"[All Fields] OR \"Penn State Worry\"[All Fields]) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "screening-measurement",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (screen* OR psychometric* OR \"GAD-7\" OR \"GAD-2\" OR \"HAM-A\" OR \"Hamilton Anxiety\" OR \"Penn State Worry\") AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"screen*\"[All Fields] OR \"psychometric*\"[All Fields] OR \"GAD-7\"[All Fields] OR \"GAD-2\"[All Fields] OR \"HAM-A\"[All Fields] OR \"Hamilton Anxiety\"[All Fields] OR \"Penn State Worry\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "cbt",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (\"cognitive behavioral\" OR \"cognitive behavioural\" OR CBT OR \"applied relaxation\")",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"cognitive behavioral\"[All Fields] OR \"cognitive behavioural\"[All Fields] OR \"CBT\"[All Fields] OR \"applied relaxation\"[All Fields]) AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "cbt",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (\"cognitive behavioral\" OR \"cognitive behavioural\" OR CBT OR \"applied relaxation\") AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"cognitive behavioral\"[All Fields] OR \"cognitive behavioural\"[All Fields] OR \"CBT\"[All Fields] OR \"applied relaxation\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "other-psychological",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (metacognitive OR mindfulness OR acceptance OR psychodynamic OR exercise OR acupuncture OR psychotherapy)",
      "datetype": "pdat",
      "count": "4",
      "retmax": "4",
      "retstart": "0",
      "idlist": [
        "42901716",
        "42897714",
        "42896155",
        "42895653"
      ],
      "translationset": [
        {
          "from": "metacognitive",
          "to": "\"metacognition\"[MeSH Terms] OR \"metacognition\"[All Fields] OR \"metacognitions\"[All Fields] OR \"metacognitive\"[All Fields] OR \"metacognitively\"[All Fields]"
        },
        {
          "from": "mindfulness",
          "to": "\"mind's\"[All Fields] OR \"minded\"[All Fields] OR \"mindful\"[All Fields] OR \"mindfulness\"[MeSH Terms] OR \"mindfulness\"[All Fields] OR \"minding\"[All Fields] OR \"minds\"[All Fields]"
        },
        {
          "from": "acceptance",
          "to": "\"accept\"[All Fields] OR \"acceptabilities\"[All Fields] OR \"acceptability\"[All Fields] OR \"acceptable\"[All Fields] OR \"acceptably\"[All Fields] OR \"acceptance\"[All Fields] OR \"acceptances\"[All Fields] OR \"acceptation\"[All Fields] OR \"accepted\"[All Fields] OR \"accepter\"[All Fields] OR \"accepters\"[All Fields] OR \"accepting\"[All Fields] OR \"accepts\"[All Fields]"
        },
        {
          "from": "psychodynamic",
          "to": "\"psychodynamic\"[All Fields] OR \"psychodynamical\"[All Fields] OR \"psychodynamically\"[All Fields] OR \"psychodynamics\"[All Fields]"
        },
        {
          "from": "exercise",
          "to": "\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise's\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]"
        },
        {
          "from": "acupuncture",
          "to": "\"acupunctural\"[All Fields] OR \"acupuncture\"[MeSH Terms] OR \"acupuncture\"[All Fields] OR \"acupuncture therapy\"[MeSH Terms] OR (\"acupuncture\"[All Fields] AND \"therapy\"[All Fields]) OR \"acupuncture therapy\"[All Fields] OR \"acupuncture's\"[All Fields] OR \"acupunctured\"[All Fields] OR \"acupunctures\"[All Fields] OR \"acupuncturing\"[All Fields]"
        },
        {
          "from": "psychotherapy",
          "to": "\"psychotherapie\"[All Fields] OR \"psychotherapy\"[MeSH Terms] OR \"psychotherapy\"[All Fields] OR \"psychotherapies\"[All Fields] OR \"psychotherapy's\"[All Fields]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"metacognition\"[MeSH Terms] OR \"metacognition\"[All Fields] OR \"metacognitions\"[All Fields] OR \"metacognitive\"[All Fields] OR \"metacognitively\"[All Fields] OR (\"mind s\"[All Fields] OR \"minded\"[All Fields] OR \"mindful\"[All Fields] OR \"mindfulness\"[MeSH Terms] OR \"mindfulness\"[All Fields] OR \"minding\"[All Fields] OR \"minds\"[All Fields]) OR (\"accept\"[All Fields] OR \"acceptabilities\"[All Fields] OR \"acceptability\"[All Fields] OR \"acceptable\"[All Fields] OR \"acceptably\"[All Fields] OR \"acceptance\"[All Fields] OR \"acceptances\"[All Fields] OR \"acceptation\"[All Fields] OR \"accepted\"[All Fields] OR \"accepter\"[All Fields] OR \"accepters\"[All Fields] OR \"accepting\"[All Fields] OR \"accepts\"[All Fields]) OR (\"psychodynamic\"[All Fields] OR \"psychodynamical\"[All Fields] OR \"psychodynamically\"[All Fields] OR \"psychodynamics\"[All Fields]) OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]) OR (\"acupunctural\"[All Fields] OR \"acupuncture\"[MeSH Terms] OR \"acupuncture\"[All Fields] OR \"acupuncture therapy\"[MeSH Terms] OR (\"acupuncture\"[All Fields] AND \"therapy\"[All Fields]) OR \"acupuncture therapy\"[All Fields] OR \"acupuncture s\"[All Fields] OR \"acupunctured\"[All Fields] OR \"acupunctures\"[All Fields] OR \"acupuncturing\"[All Fields]) OR (\"psychotherapie\"[All Fields] OR \"psychotherapy\"[MeSH Terms] OR \"psychotherapy\"[All Fields] OR \"psychotherapies\"[All Fields] OR \"psychotherapy s\"[All Fields])) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "other-psychological",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (metacognitive OR mindfulness OR acceptance OR psychodynamic OR exercise OR acupuncture OR psychotherapy) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "metacognitive",
          "to": "\"metacognition\"[MeSH Terms] OR \"metacognition\"[All Fields] OR \"metacognitions\"[All Fields] OR \"metacognitive\"[All Fields] OR \"metacognitively\"[All Fields]"
        },
        {
          "from": "mindfulness",
          "to": "\"mind's\"[All Fields] OR \"minded\"[All Fields] OR \"mindful\"[All Fields] OR \"mindfulness\"[MeSH Terms] OR \"mindfulness\"[All Fields] OR \"minding\"[All Fields] OR \"minds\"[All Fields]"
        },
        {
          "from": "acceptance",
          "to": "\"accept\"[All Fields] OR \"acceptabilities\"[All Fields] OR \"acceptability\"[All Fields] OR \"acceptable\"[All Fields] OR \"acceptably\"[All Fields] OR \"acceptance\"[All Fields] OR \"acceptances\"[All Fields] OR \"acceptation\"[All Fields] OR \"accepted\"[All Fields] OR \"accepter\"[All Fields] OR \"accepters\"[All Fields] OR \"accepting\"[All Fields] OR \"accepts\"[All Fields]"
        },
        {
          "from": "psychodynamic",
          "to": "\"psychodynamic\"[All Fields] OR \"psychodynamical\"[All Fields] OR \"psychodynamically\"[All Fields] OR \"psychodynamics\"[All Fields]"
        },
        {
          "from": "exercise",
          "to": "\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise's\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]"
        },
        {
          "from": "acupuncture",
          "to": "\"acupunctural\"[All Fields] OR \"acupuncture\"[MeSH Terms] OR \"acupuncture\"[All Fields] OR \"acupuncture therapy\"[MeSH Terms] OR (\"acupuncture\"[All Fields] AND \"therapy\"[All Fields]) OR \"acupuncture therapy\"[All Fields] OR \"acupuncture's\"[All Fields] OR \"acupunctured\"[All Fields] OR \"acupunctures\"[All Fields] OR \"acupuncturing\"[All Fields]"
        },
        {
          "from": "psychotherapy",
          "to": "\"psychotherapie\"[All Fields] OR \"psychotherapy\"[MeSH Terms] OR \"psychotherapy\"[All Fields] OR \"psychotherapies\"[All Fields] OR \"psychotherapy's\"[All Fields]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"metacognition\"[MeSH Terms] OR \"metacognition\"[All Fields] OR \"metacognitions\"[All Fields] OR \"metacognitive\"[All Fields] OR \"metacognitively\"[All Fields] OR (\"mind s\"[All Fields] OR \"minded\"[All Fields] OR \"mindful\"[All Fields] OR \"mindfulness\"[MeSH Terms] OR \"mindfulness\"[All Fields] OR \"minding\"[All Fields] OR \"minds\"[All Fields]) OR (\"accept\"[All Fields] OR \"acceptabilities\"[All Fields] OR \"acceptability\"[All Fields] OR \"acceptable\"[All Fields] OR \"acceptably\"[All Fields] OR \"acceptance\"[All Fields] OR \"acceptances\"[All Fields] OR \"acceptation\"[All Fields] OR \"accepted\"[All Fields] OR \"accepter\"[All Fields] OR \"accepters\"[All Fields] OR \"accepting\"[All Fields] OR \"accepts\"[All Fields]) OR (\"psychodynamic\"[All Fields] OR \"psychodynamical\"[All Fields] OR \"psychodynamically\"[All Fields] OR \"psychodynamics\"[All Fields]) OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]) OR (\"acupunctural\"[All Fields] OR \"acupuncture\"[MeSH Terms] OR \"acupuncture\"[All Fields] OR \"acupuncture therapy\"[MeSH Terms] OR (\"acupuncture\"[All Fields] AND \"therapy\"[All Fields]) OR \"acupuncture therapy\"[All Fields] OR \"acupuncture s\"[All Fields] OR \"acupunctured\"[All Fields] OR \"acupunctures\"[All Fields] OR \"acupuncturing\"[All Fields]) OR (\"psychotherapie\"[All Fields] OR \"psychotherapy\"[MeSH Terms] OR \"psychotherapy\"[All Fields] OR \"psychotherapies\"[All Fields] OR \"psychotherapy s\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "ssri-snri",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (antidepressant* OR SSRI OR SNRI OR escitalopram OR sertraline OR duloxetine OR venlafaxine)",
      "datetype": "pdat",
      "count": "3",
      "retmax": "3",
      "retstart": "0",
      "idlist": [
        "42905249",
        "42904642",
        "28520380"
      ],
      "translationset": [
        {
          "from": "SSRI",
          "to": "\"selective serotonin reuptake inhibitors\"[Pharmacological Action] OR \"selective serotonin reuptake inhibitors\"[Supplementary Concept] OR \"selective serotonin reuptake inhibitors\"[All Fields] OR \"ssri\"[All Fields] OR \"selective serotonin reuptake inhibitors\"[MeSH Terms] OR (\"selective\"[All Fields] AND \"serotonin\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])"
        },
        {
          "from": "SNRI",
          "to": "\"serotonin and noradrenaline reuptake inhibitors\"[Pharmacological Action] OR \"serotonin and noradrenaline reuptake inhibitors\"[Supplementary Concept] OR \"serotonin and noradrenaline reuptake inhibitors\"[All Fields] OR \"snri\"[All Fields] OR \"serotonin and noradrenaline reuptake inhibitors\"[MeSH Terms] OR (\"serotonin\"[All Fields] AND \"noradrenaline\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])"
        },
        {
          "from": "escitalopram",
          "to": "\"escitalopram\"[Supplementary Concept] OR \"escitalopram\"[All Fields] OR \"escitalopram\"[MeSH Terms] OR \"escitalopram's\"[All Fields]"
        },
        {
          "from": "sertraline",
          "to": "\"sertralin\"[All Fields] OR \"sertraline\"[Supplementary Concept] OR \"sertraline\"[All Fields] OR \"sertraline\"[MeSH Terms] OR \"sertraline's\"[All Fields]"
        },
        {
          "from": "duloxetine",
          "to": "\"duloxetin\"[All Fields] OR \"duloxetine hydrochloride\"[Supplementary Concept] OR \"duloxetine hydrochloride\"[All Fields] OR \"duloxetine\"[All Fields] OR \"duloxetine hydrochloride\"[MeSH Terms] OR (\"duloxetine\"[All Fields] AND \"hydrochloride\"[All Fields]) OR \"duloxetine's\"[All Fields]"
        },
        {
          "from": "venlafaxine",
          "to": "\"venlafaxin\"[All Fields] OR \"venlafaxine hydrochloride\"[Supplementary Concept] OR \"venlafaxine hydrochloride\"[All Fields] OR \"venlafaxine\"[All Fields] OR \"venlafaxine hydrochloride\"[MeSH Terms] OR (\"venlafaxine\"[All Fields] AND \"hydrochloride\"[All Fields]) OR \"venlafaxine's\"[All Fields]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"antidepressant*\"[All Fields] OR (\"selective serotonin reuptake inhibitors\"[Pharmacological Action] OR \"selective serotonin reuptake inhibitors\"[Supplementary Concept] OR \"selective serotonin reuptake inhibitors\"[All Fields] OR \"ssri\"[All Fields] OR \"selective serotonin reuptake inhibitors\"[MeSH Terms] OR (\"selective\"[All Fields] AND \"serotonin\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"serotonin and noradrenaline reuptake inhibitors\"[Pharmacological Action] OR \"serotonin and noradrenaline reuptake inhibitors\"[Supplementary Concept] OR \"serotonin and noradrenaline reuptake inhibitors\"[All Fields] OR \"snri\"[All Fields] OR \"serotonin and noradrenaline reuptake inhibitors\"[MeSH Terms] OR (\"serotonin\"[All Fields] AND \"noradrenaline\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"escitalopram\"[Supplementary Concept] OR \"escitalopram\"[All Fields] OR \"escitalopram\"[MeSH Terms] OR \"escitalopram s\"[All Fields]) OR (\"sertralin\"[All Fields] OR \"sertraline\"[Supplementary Concept] OR \"sertraline\"[All Fields] OR \"sertraline\"[MeSH Terms] OR \"sertraline s\"[All Fields]) OR (\"duloxetin\"[All Fields] OR \"duloxetine hydrochloride\"[Supplementary Concept] OR \"duloxetine hydrochloride\"[All Fields] OR \"duloxetine\"[All Fields] OR \"duloxetine hydrochloride\"[MeSH Terms] OR (\"duloxetine\"[All Fields] AND \"hydrochloride\"[All Fields]) OR \"duloxetine s\"[All Fields]) OR (\"venlafaxin\"[All Fields] OR \"venlafaxine hydrochloride\"[Supplementary Concept] OR \"venlafaxine hydrochloride\"[All Fields] OR \"venlafaxine\"[All Fields] OR \"venlafaxine hydrochloride\"[MeSH Terms] OR (\"venlafaxine\"[All Fields] AND \"hydrochloride\"[All Fields]))) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "ssri-snri",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (antidepressant* OR SSRI OR SNRI OR escitalopram OR sertraline OR duloxetine OR venlafaxine) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "SSRI",
          "to": "\"selective serotonin reuptake inhibitors\"[Pharmacological Action] OR \"selective serotonin reuptake inhibitors\"[Supplementary Concept] OR \"selective serotonin reuptake inhibitors\"[All Fields] OR \"ssri\"[All Fields] OR \"selective serotonin reuptake inhibitors\"[MeSH Terms] OR (\"selective\"[All Fields] AND \"serotonin\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])"
        },
        {
          "from": "SNRI",
          "to": "\"serotonin and noradrenaline reuptake inhibitors\"[Pharmacological Action] OR \"serotonin and noradrenaline reuptake inhibitors\"[Supplementary Concept] OR \"serotonin and noradrenaline reuptake inhibitors\"[All Fields] OR \"snri\"[All Fields] OR \"serotonin and noradrenaline reuptake inhibitors\"[MeSH Terms] OR (\"serotonin\"[All Fields] AND \"noradrenaline\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])"
        },
        {
          "from": "escitalopram",
          "to": "\"escitalopram\"[Supplementary Concept] OR \"escitalopram\"[All Fields] OR \"escitalopram\"[MeSH Terms] OR \"escitalopram's\"[All Fields]"
        },
        {
          "from": "sertraline",
          "to": "\"sertralin\"[All Fields] OR \"sertraline\"[Supplementary Concept] OR \"sertraline\"[All Fields] OR \"sertraline\"[MeSH Terms] OR \"sertraline's\"[All Fields]"
        },
        {
          "from": "duloxetine",
          "to": "\"duloxetin\"[All Fields] OR \"duloxetine hydrochloride\"[Supplementary Concept] OR \"duloxetine hydrochloride\"[All Fields] OR \"duloxetine\"[All Fields] OR \"duloxetine hydrochloride\"[MeSH Terms] OR (\"duloxetine\"[All Fields] AND \"hydrochloride\"[All Fields]) OR \"duloxetine's\"[All Fields]"
        },
        {
          "from": "venlafaxine",
          "to": "\"venlafaxin\"[All Fields] OR \"venlafaxine hydrochloride\"[Supplementary Concept] OR \"venlafaxine hydrochloride\"[All Fields] OR \"venlafaxine\"[All Fields] OR \"venlafaxine hydrochloride\"[MeSH Terms] OR (\"venlafaxine\"[All Fields] AND \"hydrochloride\"[All Fields]) OR \"venlafaxine's\"[All Fields]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"antidepressant*\"[All Fields] OR (\"selective serotonin reuptake inhibitors\"[Pharmacological Action] OR \"selective serotonin reuptake inhibitors\"[Supplementary Concept] OR \"selective serotonin reuptake inhibitors\"[All Fields] OR \"ssri\"[All Fields] OR \"selective serotonin reuptake inhibitors\"[MeSH Terms] OR (\"selective\"[All Fields] AND \"serotonin\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"serotonin and noradrenaline reuptake inhibitors\"[Pharmacological Action] OR \"serotonin and noradrenaline reuptake inhibitors\"[Supplementary Concept] OR \"serotonin and noradrenaline reuptake inhibitors\"[All Fields] OR \"snri\"[All Fields] OR \"serotonin and noradrenaline reuptake inhibitors\"[MeSH Terms] OR (\"serotonin\"[All Fields] AND \"noradrenaline\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"escitalopram\"[Supplementary Concept] OR \"escitalopram\"[All Fields] OR \"escitalopram\"[MeSH Terms] OR \"escitalopram s\"[All Fields]) OR (\"sertralin\"[All Fields] OR \"sertraline\"[Supplementary Concept] OR \"sertraline\"[All Fields] OR \"sertraline\"[MeSH Terms] OR \"sertraline s\"[All Fields]) OR (\"duloxetin\"[All Fields] OR \"duloxetine hydrochloride\"[Supplementary Concept] OR \"duloxetine hydrochloride\"[All Fields] OR \"duloxetine\"[All Fields] OR \"duloxetine hydrochloride\"[MeSH Terms] OR (\"duloxetine\"[All Fields] AND \"hydrochloride\"[All Fields]) OR \"duloxetine s\"[All Fields]) OR (\"venlafaxin\"[All Fields] OR \"venlafaxine hydrochloride\"[Supplementary Concept] OR \"venlafaxine hydrochloride\"[All Fields] OR \"venlafaxine\"[All Fields] OR \"venlafaxine hydrochloride\"[MeSH Terms] OR (\"venlafaxine\"[All Fields] AND \"hydrochloride\"[All Fields]))) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "other-drugs",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (pregabalin OR benzodiazepin* OR quetiapine OR buspirone OR hydroxyzine OR cannabis OR cannabidiol OR agomelatine OR silexan)",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "pregabalin",
          "to": "\"pregabalin\"[Supplementary Concept] OR \"pregabalin\"[All Fields] OR \"pregabalin\"[MeSH Terms] OR \"pregabaline\"[All Fields] OR \"pregabalin's\"[All Fields]"
        },
        {
          "from": "quetiapine",
          "to": "\"quetiapin\"[All Fields] OR \"quetiapine fumarate\"[Supplementary Concept] OR \"quetiapine fumarate\"[All Fields] OR \"quetiapine\"[All Fields] OR \"quetiapine fumarate\"[MeSH Terms] OR (\"quetiapine\"[All Fields] AND \"fumarate\"[All Fields]) OR \"quetiapine's\"[All Fields]"
        },
        {
          "from": "buspirone",
          "to": "\"buspirone\"[Supplementary Concept] OR \"buspirone\"[All Fields] OR \"buspiron\"[All Fields] OR \"buspirone\"[MeSH Terms] OR \"buspirone's\"[All Fields]"
        },
        {
          "from": "hydroxyzine",
          "to": "\"hydroxyzine\"[Supplementary Concept] OR \"hydroxyzine\"[All Fields] OR \"hydroxyzine\"[MeSH Terms]"
        },
        {
          "from": "cannabis",
          "to": "\"cannabis\"[MeSH Terms] OR \"cannabis\"[All Fields] OR \"cannabi\"[All Fields] OR \"cannabis's\"[All Fields]"
        },
        {
          "from": "cannabidiol",
          "to": "\"cannabidiol\"[Supplementary Concept] OR \"cannabidiol\"[All Fields] OR \"cannabidiol\"[MeSH Terms] OR \"cannabidiolic\"[All Fields]"
        },
        {
          "from": "agomelatine",
          "to": "\"agomelatin\"[All Fields] OR \"agomelatine\"[Supplementary Concept] OR \"agomelatine\"[All Fields] OR \"agomelatine's\"[All Fields]"
        },
        {
          "from": "silexan",
          "to": "\"lavender oil\"[Supplementary Concept] OR \"lavender oil\"[All Fields] OR \"silexan\"[All Fields]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"pregabalin\"[Supplementary Concept] OR \"pregabalin\"[All Fields] OR \"pregabalin\"[MeSH Terms] OR \"pregabaline\"[All Fields] OR \"pregabalin s\"[All Fields] OR \"benzodiazepin*\"[All Fields] OR (\"quetiapin\"[All Fields] OR \"quetiapine fumarate\"[Supplementary Concept] OR \"quetiapine fumarate\"[All Fields] OR \"quetiapine\"[All Fields] OR \"quetiapine fumarate\"[MeSH Terms] OR (\"quetiapine\"[All Fields] AND \"fumarate\"[All Fields]) OR \"quetiapine s\"[All Fields]) OR (\"buspirone\"[Supplementary Concept] OR \"buspirone\"[All Fields] OR \"buspiron\"[All Fields] OR \"buspirone\"[MeSH Terms] OR \"buspirone s\"[All Fields]) OR (\"hydroxyzine\"[Supplementary Concept] OR \"hydroxyzine\"[All Fields] OR \"hydroxyzine\"[MeSH Terms]) OR (\"cannabis\"[MeSH Terms] OR \"cannabis\"[All Fields] OR \"cannabi\"[All Fields] OR \"cannabis s\"[All Fields]) OR (\"cannabidiol\"[Supplementary Concept] OR \"cannabidiol\"[All Fields] OR \"cannabidiol\"[MeSH Terms] OR \"cannabidiolic\"[All Fields]) OR (\"agomelatin\"[All Fields] OR \"agomelatine\"[Supplementary Concept] OR \"agomelatine\"[All Fields] OR \"agomelatine s\"[All Fields]) OR (\"lavender oil\"[Supplementary Concept] OR \"lavender oil\"[All Fields] OR \"silexan\"[All Fields])) AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "other-drugs",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (pregabalin OR benzodiazepin* OR quetiapine OR buspirone OR hydroxyzine OR cannabis OR cannabidiol OR agomelatine OR silexan) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "pregabalin",
          "to": "\"pregabalin\"[Supplementary Concept] OR \"pregabalin\"[All Fields] OR \"pregabalin\"[MeSH Terms] OR \"pregabaline\"[All Fields] OR \"pregabalin's\"[All Fields]"
        },
        {
          "from": "quetiapine",
          "to": "\"quetiapin\"[All Fields] OR \"quetiapine fumarate\"[Supplementary Concept] OR \"quetiapine fumarate\"[All Fields] OR \"quetiapine\"[All Fields] OR \"quetiapine fumarate\"[MeSH Terms] OR (\"quetiapine\"[All Fields] AND \"fumarate\"[All Fields]) OR \"quetiapine's\"[All Fields]"
        },
        {
          "from": "buspirone",
          "to": "\"buspirone\"[Supplementary Concept] OR \"buspirone\"[All Fields] OR \"buspiron\"[All Fields] OR \"buspirone\"[MeSH Terms] OR \"buspirone's\"[All Fields]"
        },
        {
          "from": "hydroxyzine",
          "to": "\"hydroxyzine\"[Supplementary Concept] OR \"hydroxyzine\"[All Fields] OR \"hydroxyzine\"[MeSH Terms]"
        },
        {
          "from": "cannabis",
          "to": "\"cannabis\"[MeSH Terms] OR \"cannabis\"[All Fields] OR \"cannabi\"[All Fields] OR \"cannabis's\"[All Fields]"
        },
        {
          "from": "cannabidiol",
          "to": "\"cannabidiol\"[Supplementary Concept] OR \"cannabidiol\"[All Fields] OR \"cannabidiol\"[MeSH Terms] OR \"cannabidiolic\"[All Fields]"
        },
        {
          "from": "agomelatine",
          "to": "\"agomelatin\"[All Fields] OR \"agomelatine\"[Supplementary Concept] OR \"agomelatine\"[All Fields] OR \"agomelatine's\"[All Fields]"
        },
        {
          "from": "silexan",
          "to": "\"lavender oil\"[Supplementary Concept] OR \"lavender oil\"[All Fields] OR \"silexan\"[All Fields]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"pregabalin\"[Supplementary Concept] OR \"pregabalin\"[All Fields] OR \"pregabalin\"[MeSH Terms] OR \"pregabaline\"[All Fields] OR \"pregabalin s\"[All Fields] OR \"benzodiazepin*\"[All Fields] OR (\"quetiapin\"[All Fields] OR \"quetiapine fumarate\"[Supplementary Concept] OR \"quetiapine fumarate\"[All Fields] OR \"quetiapine\"[All Fields] OR \"quetiapine fumarate\"[MeSH Terms] OR (\"quetiapine\"[All Fields] AND \"fumarate\"[All Fields]) OR \"quetiapine s\"[All Fields]) OR (\"buspirone\"[Supplementary Concept] OR \"buspirone\"[All Fields] OR \"buspiron\"[All Fields] OR \"buspirone\"[MeSH Terms] OR \"buspirone s\"[All Fields]) OR (\"hydroxyzine\"[Supplementary Concept] OR \"hydroxyzine\"[All Fields] OR \"hydroxyzine\"[MeSH Terms]) OR (\"cannabis\"[MeSH Terms] OR \"cannabis\"[All Fields] OR \"cannabi\"[All Fields] OR \"cannabis s\"[All Fields]) OR (\"cannabidiol\"[Supplementary Concept] OR \"cannabidiol\"[All Fields] OR \"cannabidiol\"[MeSH Terms] OR \"cannabidiolic\"[All Fields]) OR (\"agomelatin\"[All Fields] OR \"agomelatine\"[Supplementary Concept] OR \"agomelatine\"[All Fields] OR \"agomelatine s\"[All Fields]) OR (\"lavender oil\"[Supplementary Concept] OR \"lavender oil\"[All Fields] OR \"silexan\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "digital-remote",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (digital OR internet OR remote OR online OR telehealth OR app OR chatbot)",
      "datetype": "pdat",
      "count": "1",
      "retmax": "1",
      "retstart": "0",
      "idlist": [
        "42896155"
      ],
      "translationset": [
        {
          "from": "digital",
          "to": "\"digitalisation\"[All Fields] OR \"digitalised\"[All Fields] OR \"digitalization\"[All Fields] OR \"digitalize\"[All Fields] OR \"digitalized\"[All Fields] OR \"digitalizer\"[All Fields] OR \"digitalizing\"[All Fields] OR \"digitally\"[All Fields] OR \"digitals\"[All Fields] OR \"digitization\"[All Fields] OR \"digitizations\"[All Fields] OR \"digitize\"[All Fields] OR \"digitized\"[All Fields] OR \"digitizer\"[All Fields] OR \"digitizers\"[All Fields] OR \"digitizes\"[All Fields] OR \"digitizing\"[All Fields] OR \"radiographic image enhancement\"[MeSH Terms] OR (\"radiographic\"[All Fields] AND \"image\"[All Fields] AND \"enhancement\"[All Fields]) OR \"radiographic image enhancement\"[All Fields] OR \"digital\"[All Fields]"
        },
        {
          "from": "internet",
          "to": "\"internet\"[MeSH Terms] OR \"internet\"[All Fields] OR \"internet's\"[All Fields] OR \"internets\"[All Fields]"
        },
        {
          "from": "remote",
          "to": "\"remote\"[All Fields] OR \"remotely\"[All Fields] OR \"remoteness\"[All Fields] OR \"remotes\"[All Fields]"
        },
        {
          "from": "telehealth",
          "to": "\"telehealth's\"[All Fields] OR \"telemedicine\"[MeSH Terms] OR \"telemedicine\"[All Fields] OR \"telehealth\"[All Fields]"
        },
        {
          "from": "app",
          "to": "\"Australas Plant Pathol\"[Journal:__jid100955348] OR \"app\"[All Fields]"
        },
        {
          "from": "chatbot",
          "to": "\"generative artificial intelligence\"[MeSH Terms] OR (\"generative\"[All Fields] AND \"artificial\"[All Fields] AND \"intelligence\"[All Fields]) OR \"generative artificial intelligence\"[All Fields] OR \"chatbot\"[All Fields]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"digitalisation\"[All Fields] OR \"digitalised\"[All Fields] OR \"digitalization\"[All Fields] OR \"digitalize\"[All Fields] OR \"digitalized\"[All Fields] OR \"digitalizer\"[All Fields] OR \"digitalizing\"[All Fields] OR \"digitally\"[All Fields] OR \"digitals\"[All Fields] OR \"digitization\"[All Fields] OR \"digitizations\"[All Fields] OR \"digitize\"[All Fields] OR \"digitized\"[All Fields] OR \"digitizer\"[All Fields] OR \"digitizers\"[All Fields] OR \"digitizes\"[All Fields] OR \"digitizing\"[All Fields] OR \"radiographic image enhancement\"[MeSH Terms] OR (\"radiographic\"[All Fields] AND \"image\"[All Fields] AND \"enhancement\"[All Fields]) OR \"radiographic image enhancement\"[All Fields] OR \"digital\"[All Fields] OR (\"internet\"[MeSH Terms] OR \"internet\"[All Fields] OR \"internet s\"[All Fields] OR \"internets\"[All Fields]) OR (\"remote\"[All Fields] OR \"remotely\"[All Fields] OR \"remoteness\"[All Fields] OR \"remotes\"[All Fields]) OR \"online\"[All Fields] OR (\"telehealth s\"[All Fields] OR \"telemedicine\"[MeSH Terms] OR \"telemedicine\"[All Fields] OR \"telehealth\"[All Fields]) OR (\"australas plant pathol\"[Journal] OR \"app\"[All Fields]) OR (\"generative artificial intelligence\"[MeSH Terms] OR (\"generative\"[All Fields] AND \"artificial\"[All Fields] AND \"intelligence\"[All Fields]) OR \"generative artificial intelligence\"[All Fields] OR \"chatbot\"[All Fields])) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "digital-remote",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (digital OR internet OR remote OR online OR telehealth OR app OR chatbot) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "digital",
          "to": "\"digitalisation\"[All Fields] OR \"digitalised\"[All Fields] OR \"digitalization\"[All Fields] OR \"digitalize\"[All Fields] OR \"digitalized\"[All Fields] OR \"digitalizer\"[All Fields] OR \"digitalizing\"[All Fields] OR \"digitally\"[All Fields] OR \"digitals\"[All Fields] OR \"digitization\"[All Fields] OR \"digitizations\"[All Fields] OR \"digitize\"[All Fields] OR \"digitized\"[All Fields] OR \"digitizer\"[All Fields] OR \"digitizers\"[All Fields] OR \"digitizes\"[All Fields] OR \"digitizing\"[All Fields] OR \"radiographic image enhancement\"[MeSH Terms] OR (\"radiographic\"[All Fields] AND \"image\"[All Fields] AND \"enhancement\"[All Fields]) OR \"radiographic image enhancement\"[All Fields] OR \"digital\"[All Fields]"
        },
        {
          "from": "internet",
          "to": "\"internet\"[MeSH Terms] OR \"internet\"[All Fields] OR \"internet's\"[All Fields] OR \"internets\"[All Fields]"
        },
        {
          "from": "remote",
          "to": "\"remote\"[All Fields] OR \"remotely\"[All Fields] OR \"remoteness\"[All Fields] OR \"remotes\"[All Fields]"
        },
        {
          "from": "telehealth",
          "to": "\"telehealth's\"[All Fields] OR \"telemedicine\"[MeSH Terms] OR \"telemedicine\"[All Fields] OR \"telehealth\"[All Fields]"
        },
        {
          "from": "app",
          "to": "\"Australas Plant Pathol\"[Journal:__jid100955348] OR \"app\"[All Fields]"
        },
        {
          "from": "chatbot",
          "to": "\"generative artificial intelligence\"[MeSH Terms] OR (\"generative\"[All Fields] AND \"artificial\"[All Fields] AND \"intelligence\"[All Fields]) OR \"generative artificial intelligence\"[All Fields] OR \"chatbot\"[All Fields]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"digitalisation\"[All Fields] OR \"digitalised\"[All Fields] OR \"digitalization\"[All Fields] OR \"digitalize\"[All Fields] OR \"digitalized\"[All Fields] OR \"digitalizer\"[All Fields] OR \"digitalizing\"[All Fields] OR \"digitally\"[All Fields] OR \"digitals\"[All Fields] OR \"digitization\"[All Fields] OR \"digitizations\"[All Fields] OR \"digitize\"[All Fields] OR \"digitized\"[All Fields] OR \"digitizer\"[All Fields] OR \"digitizers\"[All Fields] OR \"digitizes\"[All Fields] OR \"digitizing\"[All Fields] OR \"radiographic image enhancement\"[MeSH Terms] OR (\"radiographic\"[All Fields] AND \"image\"[All Fields] AND \"enhancement\"[All Fields]) OR \"radiographic image enhancement\"[All Fields] OR \"digital\"[All Fields] OR (\"internet\"[MeSH Terms] OR \"internet\"[All Fields] OR \"internet s\"[All Fields] OR \"internets\"[All Fields]) OR (\"remote\"[All Fields] OR \"remotely\"[All Fields] OR \"remoteness\"[All Fields] OR \"remotes\"[All Fields]) OR \"online\"[All Fields] OR (\"telehealth s\"[All Fields] OR \"telemedicine\"[MeSH Terms] OR \"telemedicine\"[All Fields] OR \"telehealth\"[All Fields]) OR (\"australas plant pathol\"[Journal] OR \"app\"[All Fields]) OR (\"generative artificial intelligence\"[MeSH Terms] OR (\"generative\"[All Fields] AND \"artificial\"[All Fields] AND \"intelligence\"[All Fields]) OR \"generative artificial intelligence\"[All Fields] OR \"chatbot\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "resistant-pipeline",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (\"treatment resistant\" OR refractory OR neuromodulation OR stimulation OR psychedelic* OR lysergide OR ulotaront OR \"ITI-1284\" OR MM120 OR ENX-102 OR PETRA)",
      "datetype": "pdat",
      "count": "2",
      "retmax": "2",
      "retstart": "0",
      "idlist": [
        "42904642",
        "28520380"
      ],
      "translationset": [
        {
          "from": "refractory",
          "to": "\"refractories\"[All Fields] OR \"refractoriness\"[All Fields] OR \"refractory\"[All Fields]"
        },
        {
          "from": "neuromodulation",
          "to": "\"neuromodulate\"[All Fields] OR \"neuromodulating\"[All Fields] OR \"neuromodulation\"[All Fields] OR \"neuromodulations\"[All Fields] OR \"neuromodulative\"[All Fields] OR \"neurotransmitter agents\"[Pharmacological Action] OR \"neurotransmitter agents\"[Supplementary Concept] OR \"neurotransmitter agents\"[All Fields] OR \"neuromodulator\"[All Fields] OR \"neurotransmitter agents\"[MeSH Terms] OR (\"neurotransmitter\"[All Fields] AND \"agents\"[All Fields]) OR \"neuromodulators\"[All Fields]"
        },
        {
          "from": "stimulation",
          "to": "\"stimulate\"[All Fields] OR \"stimulated\"[All Fields] OR \"stimulates\"[All Fields] OR \"stimulating\"[All Fields] OR \"stimulation\"[All Fields] OR \"stimulations\"[All Fields] OR \"stimulative\"[All Fields] OR \"stimulator\"[All Fields] OR \"stimulator's\"[All Fields] OR \"stimulators\"[All Fields]"
        },
        {
          "from": "lysergide",
          "to": "\"lysergic acid diethylamide\"[Supplementary Concept] OR \"lysergic acid diethylamide\"[All Fields] OR \"lysergide\"[All Fields] OR \"lysergic acid diethylamide\"[MeSH Terms] OR (\"lysergic\"[All Fields] AND \"acid\"[All Fields] AND \"diethylamide\"[All Fields])"
        },
        {
          "from": "ulotaront",
          "to": "\"sep-363856\"[Supplementary Concept] OR \"sep-363856\"[All Fields] OR \"ulotaront\"[All Fields]"
        },
        {
          "from": "PETRA",
          "to": "\"Int Conf Pervasive Technol Relat Assist Environ\"[Journal:__jid101692031] OR \"petra\"[All Fields]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"treatment resistant\"[All Fields] OR (\"refractories\"[All Fields] OR \"refractoriness\"[All Fields] OR \"refractory\"[All Fields]) OR (\"neuromodulate\"[All Fields] OR \"neuromodulating\"[All Fields] OR \"neuromodulation\"[All Fields] OR \"neuromodulations\"[All Fields] OR \"neuromodulative\"[All Fields] OR \"neurotransmitter agents\"[Pharmacological Action] OR \"neurotransmitter agents\"[Supplementary Concept] OR \"neurotransmitter agents\"[All Fields] OR \"neuromodulator\"[All Fields] OR \"neurotransmitter agents\"[MeSH Terms] OR (\"neurotransmitter\"[All Fields] AND \"agents\"[All Fields]) OR \"neuromodulators\"[All Fields]) OR (\"stimulate\"[All Fields] OR \"stimulated\"[All Fields] OR \"stimulates\"[All Fields] OR \"stimulating\"[All Fields] OR \"stimulation\"[All Fields] OR \"stimulations\"[All Fields] OR \"stimulative\"[All Fields] OR \"stimulator\"[All Fields] OR \"stimulator s\"[All Fields] OR \"stimulators\"[All Fields]) OR \"psychedelic*\"[All Fields] OR (\"lysergic acid diethylamide\"[Supplementary Concept] OR \"lysergic acid diethylamide\"[All Fields] OR \"lysergide\"[All Fields] OR \"lysergic acid diethylamide\"[MeSH Terms] OR (\"lysergic\"[All Fields] AND \"acid\"[All Fields] AND \"diethylamide\"[All Fields])) OR (\"sep 363856\"[Supplementary Concept] OR \"sep 363856\"[All Fields] OR \"ulotaront\"[All Fields]) OR \"MM120\"[All Fields] OR \"ENX-102\"[All Fields] OR (\"int conf pervasive technol relat assist environ\"[Journal] OR \"petra\"[All Fields])) AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [
          "\"ITI-1284\""
        ],
        "outputmessages": []
      }
    },
    {
      "topic": "resistant-pipeline",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (\"treatment resistant\" OR refractory OR neuromodulation OR stimulation OR psychedelic* OR lysergide OR ulotaront OR \"ITI-1284\" OR MM120 OR ENX-102 OR PETRA) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "refractory",
          "to": "\"refractories\"[All Fields] OR \"refractoriness\"[All Fields] OR \"refractory\"[All Fields]"
        },
        {
          "from": "neuromodulation",
          "to": "\"neuromodulate\"[All Fields] OR \"neuromodulating\"[All Fields] OR \"neuromodulation\"[All Fields] OR \"neuromodulations\"[All Fields] OR \"neuromodulative\"[All Fields] OR \"neurotransmitter agents\"[Pharmacological Action] OR \"neurotransmitter agents\"[Supplementary Concept] OR \"neurotransmitter agents\"[All Fields] OR \"neuromodulator\"[All Fields] OR \"neurotransmitter agents\"[MeSH Terms] OR (\"neurotransmitter\"[All Fields] AND \"agents\"[All Fields]) OR \"neuromodulators\"[All Fields]"
        },
        {
          "from": "stimulation",
          "to": "\"stimulate\"[All Fields] OR \"stimulated\"[All Fields] OR \"stimulates\"[All Fields] OR \"stimulating\"[All Fields] OR \"stimulation\"[All Fields] OR \"stimulations\"[All Fields] OR \"stimulative\"[All Fields] OR \"stimulator\"[All Fields] OR \"stimulator's\"[All Fields] OR \"stimulators\"[All Fields]"
        },
        {
          "from": "lysergide",
          "to": "\"lysergic acid diethylamide\"[Supplementary Concept] OR \"lysergic acid diethylamide\"[All Fields] OR \"lysergide\"[All Fields] OR \"lysergic acid diethylamide\"[MeSH Terms] OR (\"lysergic\"[All Fields] AND \"acid\"[All Fields] AND \"diethylamide\"[All Fields])"
        },
        {
          "from": "ulotaront",
          "to": "\"sep-363856\"[Supplementary Concept] OR \"sep-363856\"[All Fields] OR \"ulotaront\"[All Fields]"
        },
        {
          "from": "PETRA",
          "to": "\"Int Conf Pervasive Technol Relat Assist Environ\"[Journal:__jid101692031] OR \"petra\"[All Fields]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"treatment resistant\"[All Fields] OR (\"refractories\"[All Fields] OR \"refractoriness\"[All Fields] OR \"refractory\"[All Fields]) OR (\"neuromodulate\"[All Fields] OR \"neuromodulating\"[All Fields] OR \"neuromodulation\"[All Fields] OR \"neuromodulations\"[All Fields] OR \"neuromodulative\"[All Fields] OR \"neurotransmitter agents\"[Pharmacological Action] OR \"neurotransmitter agents\"[Supplementary Concept] OR \"neurotransmitter agents\"[All Fields] OR \"neuromodulator\"[All Fields] OR \"neurotransmitter agents\"[MeSH Terms] OR (\"neurotransmitter\"[All Fields] AND \"agents\"[All Fields]) OR \"neuromodulators\"[All Fields]) OR (\"stimulate\"[All Fields] OR \"stimulated\"[All Fields] OR \"stimulates\"[All Fields] OR \"stimulating\"[All Fields] OR \"stimulation\"[All Fields] OR \"stimulations\"[All Fields] OR \"stimulative\"[All Fields] OR \"stimulator\"[All Fields] OR \"stimulator s\"[All Fields] OR \"stimulators\"[All Fields]) OR \"psychedelic*\"[All Fields] OR (\"lysergic acid diethylamide\"[Supplementary Concept] OR \"lysergic acid diethylamide\"[All Fields] OR \"lysergide\"[All Fields] OR \"lysergic acid diethylamide\"[MeSH Terms] OR (\"lysergic\"[All Fields] AND \"acid\"[All Fields] AND \"diethylamide\"[All Fields])) OR (\"sep 363856\"[Supplementary Concept] OR \"sep 363856\"[All Fields] OR \"ulotaront\"[All Fields]) OR \"MM120\"[All Fields] OR \"ENX-102\"[All Fields] OR (\"int conf pervasive technol relat assist environ\"[Journal] OR \"petra\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [
          "\"ITI-1284\""
        ],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "course-relapse",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (course OR relapse OR recurrence OR remission OR longitudinal OR \"long term\" OR cardiovascular)",
      "datetype": "pdat",
      "count": "4",
      "retmax": "4",
      "retstart": "0",
      "idlist": [
        "42906357",
        "42905249",
        "42897714",
        "42896217"
      ],
      "translationset": [
        {
          "from": "course",
          "to": "\"course\"[All Fields] OR \"course's\"[All Fields] OR \"courses\"[All Fields]"
        },
        {
          "from": "relapse",
          "to": "\"recurrence\"[MeSH Terms] OR \"recurrence\"[All Fields] OR \"relapse\"[All Fields] OR \"relapses\"[All Fields] OR \"relapsing\"[All Fields] OR \"relapsed\"[All Fields] OR \"relapser\"[All Fields] OR \"relapsers\"[All Fields]"
        },
        {
          "from": "recurrence",
          "to": "\"recurrance\"[All Fields] OR \"recurrence\"[MeSH Terms] OR \"recurrence\"[All Fields] OR \"recurrences\"[All Fields] OR \"recurrencies\"[All Fields] OR \"recurrency\"[All Fields] OR \"recurrent\"[All Fields] OR \"recurrently\"[All Fields] OR \"recurrents\"[All Fields]"
        },
        {
          "from": "remission",
          "to": "\"remission\"[All Fields] OR \"remissions\"[All Fields]"
        },
        {
          "from": "longitudinal",
          "to": "\"longitudinal\"[All Fields] OR \"longitudinally\"[All Fields]"
        },
        {
          "from": "cardiovascular",
          "to": "\"cardiovascular system\"[MeSH Terms] OR (\"cardiovascular\"[All Fields] AND \"system\"[All Fields]) OR \"cardiovascular system\"[All Fields] OR \"cardiovascular\"[All Fields] OR \"cardiovasculars\"[All Fields]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"course\"[All Fields] OR \"course s\"[All Fields] OR \"courses\"[All Fields] OR (\"recurrence\"[MeSH Terms] OR \"recurrence\"[All Fields] OR \"relapse\"[All Fields] OR \"relapses\"[All Fields] OR \"relapsing\"[All Fields] OR \"relapsed\"[All Fields] OR \"relapser\"[All Fields] OR \"relapsers\"[All Fields]) OR (\"recurrance\"[All Fields] OR \"recurrence\"[MeSH Terms] OR \"recurrence\"[All Fields] OR \"recurrences\"[All Fields] OR \"recurrencies\"[All Fields] OR \"recurrency\"[All Fields] OR \"recurrent\"[All Fields] OR \"recurrently\"[All Fields] OR \"recurrents\"[All Fields]) OR (\"remission\"[All Fields] OR \"remissions\"[All Fields]) OR (\"longitudinal\"[All Fields] OR \"longitudinally\"[All Fields]) OR \"long term\"[All Fields] OR (\"cardiovascular system\"[MeSH Terms] OR (\"cardiovascular\"[All Fields] AND \"system\"[All Fields]) OR \"cardiovascular system\"[All Fields] OR \"cardiovascular\"[All Fields] OR \"cardiovasculars\"[All Fields])) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "course-relapse",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (course OR relapse OR recurrence OR remission OR longitudinal OR \"long term\" OR cardiovascular) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "course",
          "to": "\"course\"[All Fields] OR \"course's\"[All Fields] OR \"courses\"[All Fields]"
        },
        {
          "from": "relapse",
          "to": "\"recurrence\"[MeSH Terms] OR \"recurrence\"[All Fields] OR \"relapse\"[All Fields] OR \"relapses\"[All Fields] OR \"relapsing\"[All Fields] OR \"relapsed\"[All Fields] OR \"relapser\"[All Fields] OR \"relapsers\"[All Fields]"
        },
        {
          "from": "recurrence",
          "to": "\"recurrance\"[All Fields] OR \"recurrence\"[MeSH Terms] OR \"recurrence\"[All Fields] OR \"recurrences\"[All Fields] OR \"recurrencies\"[All Fields] OR \"recurrency\"[All Fields] OR \"recurrent\"[All Fields] OR \"recurrently\"[All Fields] OR \"recurrents\"[All Fields]"
        },
        {
          "from": "remission",
          "to": "\"remission\"[All Fields] OR \"remissions\"[All Fields]"
        },
        {
          "from": "longitudinal",
          "to": "\"longitudinal\"[All Fields] OR \"longitudinally\"[All Fields]"
        },
        {
          "from": "cardiovascular",
          "to": "\"cardiovascular system\"[MeSH Terms] OR (\"cardiovascular\"[All Fields] AND \"system\"[All Fields]) OR \"cardiovascular system\"[All Fields] OR \"cardiovascular\"[All Fields] OR \"cardiovasculars\"[All Fields]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"course\"[All Fields] OR \"course s\"[All Fields] OR \"courses\"[All Fields] OR (\"recurrence\"[MeSH Terms] OR \"recurrence\"[All Fields] OR \"relapse\"[All Fields] OR \"relapses\"[All Fields] OR \"relapsing\"[All Fields] OR \"relapsed\"[All Fields] OR \"relapser\"[All Fields] OR \"relapsers\"[All Fields]) OR (\"recurrance\"[All Fields] OR \"recurrence\"[MeSH Terms] OR \"recurrence\"[All Fields] OR \"recurrences\"[All Fields] OR \"recurrencies\"[All Fields] OR \"recurrency\"[All Fields] OR \"recurrent\"[All Fields] OR \"recurrently\"[All Fields] OR \"recurrents\"[All Fields]) OR (\"remission\"[All Fields] OR \"remissions\"[All Fields]) OR (\"longitudinal\"[All Fields] OR \"longitudinally\"[All Fields]) OR \"long term\"[All Fields] OR (\"cardiovascular system\"[MeSH Terms] OR (\"cardiovascular\"[All Fields] AND \"system\"[All Fields]) OR \"cardiovascular system\"[All Fields] OR \"cardiovascular\"[All Fields] OR \"cardiovasculars\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "special-populations",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (child* OR adolescen* OR youth OR elderly OR \"older adults\" OR perinatal OR pregnan* OR postpartum OR veteran*)",
      "datetype": "pdat",
      "count": "9",
      "retmax": "9",
      "retstart": "0",
      "idlist": [
        "42906357",
        "42903361",
        "42901722",
        "42900650",
        "42897714",
        "42896217",
        "42896155",
        "42895653",
        "42575363"
      ],
      "translationset": [
        {
          "from": "youth",
          "to": "\"adolescent\"[MeSH Terms] OR \"adolescent\"[All Fields] OR \"youth\"[All Fields] OR \"youths\"[All Fields] OR \"youth's\"[All Fields]"
        },
        {
          "from": "elderly",
          "to": "\"aged\"[MeSH Terms] OR \"aged\"[All Fields] OR \"elderly\"[All Fields] OR \"elderlies\"[All Fields] OR \"elderly's\"[All Fields] OR \"elderlys\"[All Fields]"
        },
        {
          "from": "perinatal",
          "to": "\"perinatal\"[All Fields] OR \"perinatally\"[All Fields] OR \"perinatals\"[All Fields]"
        },
        {
          "from": "postpartum",
          "to": "\"postpartum period\"[MeSH Terms] OR (\"postpartum\"[All Fields] AND \"period\"[All Fields]) OR \"postpartum period\"[All Fields] OR \"postpartum\"[All Fields]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"child*\"[All Fields] OR \"adolescen*\"[All Fields] OR (\"adolescent\"[MeSH Terms] OR \"adolescent\"[All Fields] OR \"youth\"[All Fields] OR \"youths\"[All Fields] OR \"youth s\"[All Fields]) OR (\"aged\"[MeSH Terms] OR \"aged\"[All Fields] OR \"elderly\"[All Fields] OR \"elderlies\"[All Fields] OR \"elderly s\"[All Fields] OR \"elderlys\"[All Fields]) OR \"older adults\"[All Fields] OR (\"perinatal\"[All Fields] OR \"perinatally\"[All Fields] OR \"perinatals\"[All Fields]) OR \"pregnan*\"[All Fields] OR (\"postpartum period\"[MeSH Terms] OR (\"postpartum\"[All Fields] AND \"period\"[All Fields]) OR \"postpartum period\"[All Fields] OR \"postpartum\"[All Fields]) OR \"veteran*\"[All Fields]) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "special-populations",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (child* OR adolescen* OR youth OR elderly OR \"older adults\" OR perinatal OR pregnan* OR postpartum OR veteran*) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "youth",
          "to": "\"adolescent\"[MeSH Terms] OR \"adolescent\"[All Fields] OR \"youth\"[All Fields] OR \"youths\"[All Fields] OR \"youth's\"[All Fields]"
        },
        {
          "from": "elderly",
          "to": "\"aged\"[MeSH Terms] OR \"aged\"[All Fields] OR \"elderly\"[All Fields] OR \"elderlies\"[All Fields] OR \"elderly's\"[All Fields] OR \"elderlys\"[All Fields]"
        },
        {
          "from": "perinatal",
          "to": "\"perinatal\"[All Fields] OR \"perinatally\"[All Fields] OR \"perinatals\"[All Fields]"
        },
        {
          "from": "postpartum",
          "to": "\"postpartum period\"[MeSH Terms] OR (\"postpartum\"[All Fields] AND \"period\"[All Fields]) OR \"postpartum period\"[All Fields] OR \"postpartum\"[All Fields]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"child*\"[All Fields] OR \"adolescen*\"[All Fields] OR (\"adolescent\"[MeSH Terms] OR \"adolescent\"[All Fields] OR \"youth\"[All Fields] OR \"youths\"[All Fields] OR \"youth s\"[All Fields]) OR (\"aged\"[MeSH Terms] OR \"aged\"[All Fields] OR \"elderly\"[All Fields] OR \"elderlies\"[All Fields] OR \"elderly s\"[All Fields] OR \"elderlys\"[All Fields]) OR \"older adults\"[All Fields] OR (\"perinatal\"[All Fields] OR \"perinatally\"[All Fields] OR \"perinatals\"[All Fields]) OR \"pregnan*\"[All Fields] OR (\"postpartum period\"[MeSH Terms] OR (\"postpartum\"[All Fields] AND \"period\"[All Fields]) OR \"postpartum period\"[All Fields] OR \"postpartum\"[All Fields]) OR \"veteran*\"[All Fields]) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "comorbidity-primary-care",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (comorbid* OR depression OR \"primary care\" OR collaborative OR substance)",
      "datetype": "pdat",
      "count": "11",
      "retmax": "11",
      "retstart": "0",
      "idlist": [
        "42905249",
        "42904642",
        "42903361",
        "42901722",
        "42901716",
        "42897714",
        "42896217",
        "42896155",
        "42895653",
        "28520380",
        "42575363"
      ],
      "translationset": [
        {
          "from": "depression",
          "to": "\"depressed\"[All Fields] OR \"depression\"[MeSH Terms] OR \"depression\"[All Fields] OR \"depressions\"[All Fields] OR \"depression's\"[All Fields] OR \"depressive disorder\"[MeSH Terms] OR (\"depressive\"[All Fields] AND \"disorder\"[All Fields]) OR \"depressive disorder\"[All Fields] OR \"depressivity\"[All Fields] OR \"depressive\"[All Fields] OR \"depressively\"[All Fields] OR \"depressiveness\"[All Fields] OR \"depressives\"[All Fields]"
        },
        {
          "from": "collaborative",
          "to": "\"collaborate\"[All Fields] OR \"collaborated\"[All Fields] OR \"collaborates\"[All Fields] OR \"collaborating\"[All Fields] OR \"collaboration\"[All Fields] OR \"collaborations\"[All Fields] OR \"collaborative\"[All Fields] OR \"collaborative's\"[All Fields] OR \"collaboratively\"[All Fields] OR \"collaboratives\"[All Fields] OR \"collaborator\"[All Fields] OR \"collaborators\"[All Fields]"
        },
        {
          "from": "substance",
          "to": "\"substance\"[All Fields] OR \"substance's\"[All Fields] OR \"substances\"[All Fields]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"comorbid*\"[All Fields] OR (\"depressed\"[All Fields] OR \"depression\"[MeSH Terms] OR \"depression\"[All Fields] OR \"depressions\"[All Fields] OR \"depression s\"[All Fields] OR \"depressive disorder\"[MeSH Terms] OR (\"depressive\"[All Fields] AND \"disorder\"[All Fields]) OR \"depressive disorder\"[All Fields] OR \"depressivity\"[All Fields] OR \"depressive\"[All Fields] OR \"depressively\"[All Fields] OR \"depressiveness\"[All Fields] OR \"depressives\"[All Fields]) OR \"primary care\"[All Fields] OR (\"collaborate\"[All Fields] OR \"collaborated\"[All Fields] OR \"collaborates\"[All Fields] OR \"collaborating\"[All Fields] OR \"collaboration\"[All Fields] OR \"collaborations\"[All Fields] OR \"collaborative\"[All Fields] OR \"collaborative s\"[All Fields] OR \"collaboratively\"[All Fields] OR \"collaboratives\"[All Fields] OR \"collaborator\"[All Fields] OR \"collaborators\"[All Fields]) OR (\"substance\"[All Fields] OR \"substance s\"[All Fields] OR \"substances\"[All Fields])) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "comorbidity-primary-care",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (comorbid* OR depression OR \"primary care\" OR collaborative OR substance) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "depression",
          "to": "\"depressed\"[All Fields] OR \"depression\"[MeSH Terms] OR \"depression\"[All Fields] OR \"depressions\"[All Fields] OR \"depression's\"[All Fields] OR \"depressive disorder\"[MeSH Terms] OR (\"depressive\"[All Fields] AND \"disorder\"[All Fields]) OR \"depressive disorder\"[All Fields] OR \"depressivity\"[All Fields] OR \"depressive\"[All Fields] OR \"depressively\"[All Fields] OR \"depressiveness\"[All Fields] OR \"depressives\"[All Fields]"
        },
        {
          "from": "collaborative",
          "to": "\"collaborate\"[All Fields] OR \"collaborated\"[All Fields] OR \"collaborates\"[All Fields] OR \"collaborating\"[All Fields] OR \"collaboration\"[All Fields] OR \"collaborations\"[All Fields] OR \"collaborative\"[All Fields] OR \"collaborative's\"[All Fields] OR \"collaboratively\"[All Fields] OR \"collaboratives\"[All Fields] OR \"collaborator\"[All Fields] OR \"collaborators\"[All Fields]"
        },
        {
          "from": "substance",
          "to": "\"substance\"[All Fields] OR \"substance's\"[All Fields] OR \"substances\"[All Fields]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"comorbid*\"[All Fields] OR (\"depressed\"[All Fields] OR \"depression\"[MeSH Terms] OR \"depression\"[All Fields] OR \"depressions\"[All Fields] OR \"depression s\"[All Fields] OR \"depressive disorder\"[MeSH Terms] OR (\"depressive\"[All Fields] AND \"disorder\"[All Fields]) OR \"depressive disorder\"[All Fields] OR \"depressivity\"[All Fields] OR \"depressive\"[All Fields] OR \"depressively\"[All Fields] OR \"depressiveness\"[All Fields] OR \"depressives\"[All Fields]) OR \"primary care\"[All Fields] OR (\"collaborate\"[All Fields] OR \"collaborated\"[All Fields] OR \"collaborates\"[All Fields] OR \"collaborating\"[All Fields] OR \"collaboration\"[All Fields] OR \"collaborations\"[All Fields] OR \"collaborative\"[All Fields] OR \"collaborative s\"[All Fields] OR \"collaboratively\"[All Fields] OR \"collaboratives\"[All Fields] OR \"collaborator\"[All Fields] OR \"collaborators\"[All Fields]) OR (\"substance\"[All Fields] OR \"substance s\"[All Fields] OR \"substances\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "guidelines-safety-patient",
      "kind": "topic",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (guideline* OR consensus OR recommendation* OR safety OR suicid* OR adverse OR withdrawal OR qualitative OR \"patient experience\" OR preference)",
      "datetype": "pdat",
      "count": "4",
      "retmax": "4",
      "retstart": "0",
      "idlist": [
        "42900650",
        "42896217",
        "42895653",
        "28520380"
      ],
      "translationset": [
        {
          "from": "consensus",
          "to": "\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]"
        },
        {
          "from": "safety",
          "to": "\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]"
        },
        {
          "from": "adverse",
          "to": "\"adverse\"[All Fields] OR \"adversely\"[All Fields] OR \"adverses\"[All Fields]"
        },
        {
          "from": "withdrawal",
          "to": "\"withdraw\"[All Fields] OR \"withdrawal\"[All Fields] OR \"withdrawals\"[All Fields] OR \"withdrawing\"[All Fields] OR \"withdraws\"[All Fields]"
        },
        {
          "from": "qualitative",
          "to": "\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields]"
        },
        {
          "from": "preference",
          "to": "\"prefer\"[All Fields] OR \"preferable\"[All Fields] OR \"preferably\"[All Fields] OR \"prefered\"[All Fields] OR \"preference\"[All Fields] OR \"preferences\"[All Fields] OR \"preferred\"[All Fields] OR \"preferring\"[All Fields] OR \"prefers\"[All Fields]"
        }
      ],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND (\"guideline*\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR \"recommendation*\"[All Fields] OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]) OR \"suicid*\"[All Fields] OR (\"adverse\"[All Fields] OR \"adversely\"[All Fields] OR \"adverses\"[All Fields]) OR (\"withdraw\"[All Fields] OR \"withdrawal\"[All Fields] OR \"withdrawals\"[All Fields] OR \"withdrawing\"[All Fields] OR \"withdraws\"[All Fields]) OR (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields]) OR \"patient experience\"[All Fields] OR (\"prefer\"[All Fields] OR \"preferable\"[All Fields] OR \"preferably\"[All Fields] OR \"prefered\"[All Fields] OR \"preference\"[All Fields] OR \"preferences\"[All Fields] OR \"preferred\"[All Fields] OR \"preferring\"[All Fields] OR \"prefers\"[All Fields])) AND 2026/10/17:2026/10/24[Date - Publication]"
    },
    {
      "topic": "guidelines-safety-patient",
      "kind": "cochrane",
      "query": "(\"anxiety\" OR (\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")) AND (guideline* OR consensus OR recommendation* OR safety OR suicid* OR adverse OR withdrawal OR qualitative OR \"patient experience\" OR preference) AND \"Cochrane Database Syst Rev\"[jour]",
      "datetype": "pdat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "consensus",
          "to": "\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]"
        },
        {
          "from": "safety",
          "to": "\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]"
        },
        {
          "from": "adverse",
          "to": "\"adverse\"[All Fields] OR \"adversely\"[All Fields] OR \"adverses\"[All Fields]"
        },
        {
          "from": "withdrawal",
          "to": "\"withdraw\"[All Fields] OR \"withdrawal\"[All Fields] OR \"withdrawals\"[All Fields] OR \"withdrawing\"[All Fields] OR \"withdraws\"[All Fields]"
        },
        {
          "from": "qualitative",
          "to": "\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields]"
        },
        {
          "from": "preference",
          "to": "\"prefer\"[All Fields] OR \"preferable\"[All Fields] OR \"preferably\"[All Fields] OR \"prefered\"[All Fields] OR \"preference\"[All Fields] OR \"preferences\"[All Fields] OR \"preferred\"[All Fields] OR \"preferring\"[All Fields] OR \"prefers\"[All Fields]"
        }
      ],
      "querytranslation": "(\"anxiety\"[All Fields] OR (\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields])) AND (\"guideline*\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR \"recommendation*\"[All Fields] OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]) OR \"suicid*\"[All Fields] OR (\"adverse\"[All Fields] OR \"adversely\"[All Fields] OR \"adverses\"[All Fields]) OR (\"withdraw\"[All Fields] OR \"withdrawal\"[All Fields] OR \"withdrawals\"[All Fields] OR \"withdrawing\"[All Fields] OR \"withdraws\"[All Fields]) OR (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields]) OR \"patient experience\"[All Fields] OR (\"prefer\"[All Fields] OR \"preferable\"[All Fields] OR \"preferably\"[All Fields] OR \"prefered\"[All Fields] OR \"preference\"[All Fields] OR \"preferences\"[All Fields] OR \"preferred\"[All Fields] OR \"preferring\"[All Fields] OR \"prefers\"[All Fields])) AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/10/17:2026/10/24[Date - Publication]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "broad-entry",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\")",
      "datetype": "edat",
      "count": "26",
      "retmax": "26",
      "retstart": "0",
      "idlist": [
        "42918111",
        "42908008",
        "42907974",
        "42907817",
        "42907464",
        "42906357",
        "42905249",
        "42904642",
        "42903361",
        "42903259",
        "42902415",
        "42902165",
        "42901722",
        "42901716",
        "42901095",
        "42900650",
        "42898441",
        "42897714",
        "42896481",
        "42896217",
        "42896155",
        "42895653",
        "42894670",
        "28520380",
        "42891141",
        "42889226"
      ],
      "translationset": [],
      "querytranslation": "(\"generalized anxiety disorder\"[All Fields] OR \"generalised anxiety disorder\"[All Fields]) AND 2026/10/17:2026/10/24[Date - Entry]"
    },
    {
      "topic": "instruments-entry",
      "query": "(\"GAD-7\" OR \"GAD-2\" OR \"Hamilton Anxiety\" OR \"Penn State Worry Questionnaire\")",
      "datetype": "edat",
      "count": "39",
      "retmax": "39",
      "retstart": "0",
      "idlist": [
        "42918508",
        "42918352",
        "42918111",
        "42914866",
        "42914599",
        "42913870",
        "42912777",
        "42908008",
        "42907956",
        "42907817",
        "42905896",
        "42905249",
        "42904719",
        "42903690",
        "42903361",
        "42903259",
        "42902415",
        "42901722",
        "42901488",
        "42901446",
        "42898441",
        "42897820",
        "42897493",
        "42897370",
        "42896481",
        "42896217",
        "42896175",
        "42896155",
        "42894670",
        "42894373",
        "42892399",
        "42892201",
        "42892192",
        "42892096",
        "42891586",
        "42891277",
        "42890720",
        "42889802",
        "42888613"
      ],
      "translationset": [],
      "querytranslation": "(\"GAD-7\"[All Fields] OR \"GAD-2\"[All Fields] OR \"Hamilton Anxiety\"[All Fields] OR \"Penn State Worry Questionnaire\"[All Fields]) AND 2026/10/17:2026/10/24[Date - Entry]"
    },
    {
      "topic": "cochrane-broad",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (anxiety OR anxiolytic* OR worry OR pregabalin OR antidepressant* OR psychotherapy)",
      "datetype": "edat",
      "count": "0",
      "retmax": "0",
      "retstart": "0",
      "idlist": [],
      "translationset": [
        {
          "from": "anxiety",
          "to": "\"anxiety\"[MeSH Terms] OR \"anxiety\"[All Fields] OR \"anxieties\"[All Fields] OR \"anxiety's\"[All Fields]"
        },
        {
          "from": "worry",
          "to": "\"worried\"[All Fields] OR \"worries\"[All Fields] OR \"worry\"[All Fields] OR \"worrying\"[All Fields]"
        },
        {
          "from": "pregabalin",
          "to": "\"pregabalin\"[Supplementary Concept] OR \"pregabalin\"[All Fields] OR \"pregabalin\"[MeSH Terms] OR \"pregabaline\"[All Fields] OR \"pregabalin's\"[All Fields]"
        },
        {
          "from": "psychotherapy",
          "to": "\"psychotherapie\"[All Fields] OR \"psychotherapy\"[MeSH Terms] OR \"psychotherapy\"[All Fields] OR \"psychotherapies\"[All Fields] OR \"psychotherapy's\"[All Fields]"
        }
      ],
      "querytranslation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"anxiety\"[MeSH Terms] OR \"anxiety\"[All Fields] OR \"anxieties\"[All Fields] OR \"anxiety s\"[All Fields] OR \"anxiolytic*\"[All Fields] OR (\"worried\"[All Fields] OR \"worries\"[All Fields] OR \"worry\"[All Fields] OR \"worrying\"[All Fields]) OR (\"pregabalin\"[Supplementary Concept] OR \"pregabalin\"[All Fields] OR \"pregabalin\"[MeSH Terms] OR \"pregabaline\"[All Fields] OR \"pregabalin s\"[All Fields]) OR \"antidepressant*\"[All Fields] OR (\"psychotherapie\"[All Fields] OR \"psychotherapy\"[MeSH Terms] OR \"psychotherapy\"[All Fields] OR \"psychotherapies\"[All Fields] OR \"psychotherapy s\"[All Fields])) AND 2026/10/17:2026/10/24[Date - Entry]",
      "warninglist": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    }
  ],
  "retrieved_pmids": [
    "28520380",
    "42575363",
    "42888613",
    "42889226",
    "42889802",
    "42890720",
    "42891141",
    "42891277",
    "42891586",
    "42892096",
    "42892192",
    "42892201",
    "42892399",
    "42894373",
    "42894670",
    "42895653",
    "42896155",
    "42896175",
    "42896217",
    "42896481",
    "42897370",
    "42897493",
    "42897714",
    "42897820",
    "42898441",
    "42900650",
    "42901095",
    "42901446",
    "42901488",
    "42901716",
    "42901722",
    "42902165",
    "42902415",
    "42903259",
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    "42903690",
    "42904642",
    "42904719",
    "42905249",
    "42905896",
    "42906357",
    "42907464",
    "42907817",
    "42907956",
    "42907974",
    "42908008",
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    "42914599",
    "42914866",
    "42918111",
    "42918352",
    "42918508"
  ],
  "unpaywall": "not used; contact variable unset",
  "sources_queried": [
    "PubMed E-utilities esearch and efetch",
    "Europe PMC REST search (15 topic queries) and fullTextXML",
    "Crossref works endpoint, no mailto",
    "ClinicalTrials.gov v2 individual records and dated study searches",
    "ISRCTN XML API individual trial and lastEdited date-filtered search",
    "WHO ICTRP query result page (partial pagination only)",
    "ChiCTR search attempted: HTTP 200 bot challenge, no usable records",
    "NICE CG113, APA guideline page, AWMF register and direct PDF",
    "BAP, WFSBP and CANMAT official pages via web search",
    "WHO anxiety fact sheet and Global Health Estimates update",
    "ADAA, Mind, NAMI, Anxiety Canada, Anxiety UK, SADAG; GuíaSalud / SESCS guideline and patient-resource pages"
  ],
  "sources_not_queried_or_limited": {
    "Cochrane Library/CENTRAL": "not queried; HTTP 403 reported in SOURCES.md; CDSR searched through PubMed per topic",
    "SciELO/LILACS": "could not be searched (HTTP 403 per task/SOURCES.md); no regional absence asserted",
    "Unpaywall": "skipped; LIFEBANK_CONTACT_EMAIL unset",
    "Embase/Scopus/Web of Science": "not searched; no credentials",
    "OpenAlex/DOAJ": "not queried; not required to resolve retained records",
    "WHO ICTRP": "21 records/20 trials reported; first result page only, no comprehensive update-date sweep",
    "ChiCTR": "bot challenge; not a completed search"
  },
  "europe_pmc_queries": [
    {
      "topic": "overview",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND FIRST_PDATE:[2026-10-17 TO 2026-10-24]",
      "hit_count": 28,
      "record_keys": [
        "MED:42906357",
        "MED:42898441",
        "PPR:PPR1349186",
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        "PMC:PMC13676468",
        "PMC:PMC13668812",
        "MED:42897301",
        "PMC:PMC13671987",
        "PMC:PMC13668871",
        "PMC:PMC13680229",
        "PMC:PMC13670509",
        "PMC:PMC13668534",
        "PMC:PMC13674341",
        "PMC:PMC13680482",
        "MED:42897689",
        "PMC:PMC13680196"
      ]
    },
    {
      "topic": "diagnosis-boundary",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (diagnos* OR classification OR criteria OR excessiveness OR uncontrollab* OR taxometric*) AND FIRST_PDATE:[2026-10-17 TO 2026-10-24]",
      "hit_count": 22,
      "record_keys": [
        "MED:42898441",
        "PMC:PMC13681402",
        "PPR:PPR1349186",
        "MED:42900650",
        "MED:42905249",
        "PMC:PMC13680567",
        "MED:42896155",
        "PMC:PMC13671987",
        "MED:42897575",
        "MED:42895653",
        "PMC:PMC13680419",
        "PMC:PMC13676468",
        "MED:42897301",
        "PMC:PMC13668534",
        "PMC:PMC13668871",
        "PMC:PMC13669189",
        "PMC:PMC13680482",
        "PMC:PMC13668812",
        "PMC:PMC13670509",
        "PMC:PMC13680196",
        "PMC:PMC13674341",
        "MED:42897689"
      ]
    },
    {
      "topic": "epidemiology-burden",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (prevalence OR incidence OR epidemiolog* OR burden OR mortality OR \"treatment gap\") AND FIRST_PDATE:[2026-10-17 TO 2026-10-24]",
      "hit_count": 20,
      "record_keys": [
        "MED:42898441",
        "MED:42895653",
        "PMC:PMC13680567",
        "MED:42896217",
        "MED:42897714",
        "PMC:PMC13676468",
        "MED:42903361",
        "MED:42896481",
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        "PMC:PMC13681402",
        "PMC:PMC13668534",
        "PMC:PMC13671987",
        "PMC:PMC13680419",
        "PMC:PMC13668812",
        "PMC:PMC13670509",
        "MED:42897689",
        "PMC:PMC13680229",
        "PMC:PMC13674341",
        "PMC:PMC13680482"
      ]
    },
    {
      "topic": "mechanism",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (worry OR \"intolerance of uncertainty\" OR neuroimag* OR genetic* OR biomarker* OR inflammation OR pathophysiology) AND FIRST_PDATE:[2026-10-17 TO 2026-10-24]",
      "hit_count": 12,
      "record_keys": [
        "MED:42898441",
        "PPR:PPR1349186",
        "PMC:PMC13676468",
        "MED:42896155",
        "PMC:PMC13671987",
        "PMC:PMC13680567",
        "PMC:PMC13681402",
        "MED:42895653",
        "PMC:PMC13668871",
        "MED:42897575",
        "PMC:PMC13680482",
        "PMC:PMC13668534"
      ]
    },
    {
      "topic": "screening-measurement",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (screen* OR psychometric* OR \"GAD-7\" OR \"GAD-2\" OR \"HAM-A\" OR \"Hamilton Anxiety\" OR \"Penn State Worry\") AND FIRST_PDATE:[2026-10-17 TO 2026-10-24]",
      "hit_count": 25,
      "record_keys": [
        "MED:42898441",
        "MED:42903361",
        "PMC:PMC13680419",
        "PMC:PMC13680196",
        "MED:42896155",
        "MED:42896217",
        "MED:42905249",
        "PMC:PMC13680567",
        "MED:42896481",
        "PMC:PMC13669189",
        "PMC:PMC13674341",
        "PMC:PMC13668534",
        "MED:42897575",
        "MED:42900650",
        "PMC:PMC13670509",
        "PMC:PMC13680229",
        "PMC:PMC13681402",
        "MED:42895653",
        "PMC:PMC13680482",
        "MED:42897689",
        "MED:42897301",
        "PMC:PMC13676468",
        "PMC:PMC13668812",
        "PMC:PMC13671987",
        "PMC:PMC13668871"
      ]
    },
    {
      "topic": "cbt",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (\"cognitive behavioral\" OR \"cognitive behavioural\" OR CBT OR \"applied relaxation\") AND FIRST_PDATE:[2026-10-17 TO 2026-10-24]",
      "hit_count": 5,
      "record_keys": [
        "PMC:PMC13676468",
        "MED:42898441",
        "MED:42897575",
        "PMC:PMC13668871",
        "PMC:PMC13680196"
      ]
    },
    {
      "topic": "other-psychological",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (metacognitive OR mindfulness OR acceptance OR psychodynamic OR exercise OR acupuncture OR psychotherapy) AND FIRST_PDATE:[2026-10-17 TO 2026-10-24]",
      "hit_count": 18,
      "record_keys": [
        "MED:42896155",
        "PMC:PMC13680196",
        "PMC:PMC13681402",
        "MED:42895653",
        "MED:42897575",
        "PMC:PMC13676468",
        "PMC:PMC13670509",
        "PMC:PMC13669189",
        "PMC:PMC13680419",
        "PMC:PMC13668871",
        "PMC:PMC13680229",
        "MED:42897301",
        "PMC:PMC13668812",
        "PMC:PMC13674341",
        "PMC:PMC13671987",
        "PMC:PMC13668534",
        "PMC:PMC13680482",
        "MED:42897689"
      ]
    },
    {
      "topic": "ssri-snri",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (antidepressant* OR SSRI OR SNRI OR escitalopram OR sertraline OR duloxetine OR venlafaxine) AND FIRST_PDATE:[2026-10-17 TO 2026-10-24]",
      "hit_count": 6,
      "record_keys": [
        "PMC:PMC13676468",
        "MED:42898441",
        "MED:42905249",
        "MED:42897301",
        "PMC:PMC13668812",
        "PMC:PMC13668871"
      ]
    },
    {
      "topic": "other-drugs",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (pregabalin OR benzodiazepin* OR quetiapine OR buspirone OR hydroxyzine OR cannabis OR cannabidiol OR agomelatine OR silexan) AND FIRST_PDATE:[2026-10-17 TO 2026-10-24]",
      "hit_count": 4,
      "record_keys": [
        "MED:42898441",
        "PMC:PMC13668812",
        "PMC:PMC13680567",
        "MED:42897575"
      ]
    },
    {
      "topic": "digital-remote",
      "query": "(\"generalized anxiety disorder\" OR \"generalised anxiety disorder\") AND (digital OR internet OR remote OR online OR telehealth OR app OR chatbot) AND FIRST_PDATE:[2026-10-17 TO 2026-10-24]",
      "hit_count": 15,
      "record_keys": [
        "MED:42896155",
        "PMC:PMC13676468",
        "PMC:PMC13681402",
        "PMC:PMC13669189",
        "PMC:PMC13680229",
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      "title": "A Study to Asses Safety and Tolerability of ITI-1284 Given Alone or as an Additional Treatment in Participants With Generalized Anxiety Disorder (GAD)",
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        "date": "2030-03-04",
        "type": "ESTIMATED"
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      "nct_id": "NCT07856420",
      "title": "A Study of JNJ-99245354 (ITI-1284) as an Adjunctive Treatment in Participants With Generalized Anxiety Disorder (GAD) Who Have an Inadequate Response to GAD Treatment",
      "status": "NOT_YET_RECRUITING",
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        "count": 705,
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      "completion": {
        "date": "2030-09-28",
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      "nct_id": "NCT07866794",
      "title": "Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty Versus Applied Relaxation",
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        "date": "2026-10-08",
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      "title": "Digital Single-Session Cognitive Behavioural Therapy in Healthy Adults",
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        "count": 110,
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        "date": "2024-10-10",
        "type": "ACTUAL"
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      "title": "Feasibility and Preliminary Outcomes of Compassion-Focused Group Therapy for Depression and Anxiety",
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        "date": "2026-10-21",
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        "count": 21,
        "type": "ACTUAL"
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        "date": "2024-04-08",
        "type": "ACTUAL"
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    }
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          "nct_id": "NCT07892768",
          "title": "Effectiveness of Single-Session Acceptance and Commitment Therapy for Generalized Anxiety Symptoms.",
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            "conditions": [
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              "Anxiety"
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              "Single-Session Therapy",
              "Generalized Anxiety Symptoms",
              "University Students",
              "Psychological Inflexibility",
              "Pakistan",
              "GAD-7",
              "AAQ-II"
            ]
          },
          "has_results": false,
          "triage": "not added: mixed/symptom-selected or non-GAD scope; no results"
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          "nct_id": "NCT07891624",
          "title": "Neural Mechanisms of Real-world Emotions and Internalizing",
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            "enrollmentInfo": {
              "count": 144,
              "type": "ESTIMATED"
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          },
          "conditions": {
            "conditions": [
              "Major Depression",
              "Generalized Anxiety",
              "Emotions"
            ]
          },
          "has_results": false,
          "triage": "not added: mixed/symptom-selected or non-GAD scope; no results"
        }
      ]
    },
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        "query.cond": "Generalized Anxiety Disorder",
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        {
          "nct_id": "NCT07392645",
          "title": "Electroacupuncture for Generalized Anxiety Disorder: Clinical Efficacy and Neuroimaging Mechanisms",
          "status": {
            "statusVerifiedDate": "2026-03",
            "overallStatus": "RECRUITING",
            "expandedAccessInfo": {
              "hasExpandedAccess": false
            },
            "startDateStruct": {
              "date": "2026-03-10",
              "type": "ACTUAL"
            },
            "primaryCompletionDateStruct": {
              "date": "2027-10-31",
              "type": "ESTIMATED"
            },
            "completionDateStruct": {
              "date": "2027-12-31",
              "type": "ESTIMATED"
            },
            "studyFirstSubmitDate": "2026-01-29",
            "studyFirstSubmitQcDate": "2026-02-05",
            "studyFirstPostDateStruct": {
              "date": "2026-02-06",
              "type": "ACTUAL"
            },
            "lastUpdateSubmitDate": "2026-10-16",
            "lastUpdatePostDateStruct": {
              "date": "2026-10-21",
              "type": "ACTUAL"
            }
          },
          "design": {
            "studyType": "INTERVENTIONAL",
            "phases": [
              "NA"
            ],
            "designInfo": {
              "allocation": "RANDOMIZED",
              "interventionModel": "PARALLEL",
              "primaryPurpose": "TREATMENT",
              "maskingInfo": {
                "masking": "TRIPLE",
                "whoMasked": [
                  "PARTICIPANT",
                  "INVESTIGATOR",
                  "OUTCOMES_ASSESSOR"
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            },
            "enrollmentInfo": {
              "count": 123,
              "type": "ESTIMATED"
            }
          },
          "conditions": {
            "conditions": [
              "Generalized Anxiety Disorder"
            ],
            "keywords": [
              "Electroacupuncture",
              "Generalized Anxiety Disorder",
              "fMRI",
              "Clinical Efficacy"
            ]
          },
          "has_results": false,
          "description": {
            "briefSummary": "This study aims to evaluate the clinical efficacy and safety of electroacupuncture (EA) in treating Generalized Anxiety Disorder (GAD). Participants will be randomly assigned to an EA group, a sham EA group, or a waiting-list control group. All participants will receive monotherapy with one of three SSRIs: sertraline, paroxetine, or escitalopram. The medication will be selected by a psychiatrist according to clinical suitability, previous treatment response, and tolerability. The primary goal is to observe the reduction in anxiety symptoms using the Hamilton Anxiety Scale (HAMA). Additionally, resting-state functional MRI (rs-fMRI) will be performed before and after a single session of EA or sham EA, or a duration-matched rest period in the waiting-list control group, to assess acute changes in functional connectivity (FC), regional homogeneity (ReHo), and amplitude of low-frequency fluctuation (ALFF)."
          },
          "eligibility": {
            "eligibilityCriteria": "Inclusion Criteria:\n\n* Meet the DSM-5 diagnostic criteria for Generalized Anxiety Disorder (GAD).\n* the patient has been taking the same anxiolytic medication consistently for 2 weeks prior to enrollment.\n* HAMA score ≥ 14.\n* Right-handed（for MRI).\n* Aged 18-60 years, with at least primary school education.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Complicated with severe cardiovascular, cerebrovascular, or organic diseases.\n* History of other psychiatric disorders (e.g., schizophrenia, bipolar disorder).\n* Contraindications for MRI (e.g., metal implants, claustrophobia).\n* Pregnancy or lactation.",
            "healthyVolunteers": true,
            "sex": "ALL",
            "minimumAge": "18 Years",
            "maximumAge": "60 Years",
            "stdAges": [
              "ADULT"
            ]
          },
          "outcomes": {
            "primaryOutcomes": [
              {
                "measure": "Effective rate of HAMA score reduction at Week 4",
                "description": "The percentage of participants who achieved a HAMA score reduction rate of ≥50% from baseline. HAMA scores are evaluated to categorize outcomes as recovered, markedly effective, effective, or ineffective.",
                "timeFrame": "Week 4 (at the end of treatment)"
              }
            ],
            "secondaryOutcomes": [
              {
                "measure": "Change from Baseline in Hamilton Anxiety Scale (HAMA) Scores",
                "description": "HAMA is used to assess the severity of anxiety symptoms. It contains 14 items, including somatic and psychic anxiety. Total scores range from 0 to 56, where higher scores indicate more severe anxiety",
                "timeFrame": "Baseline, Week 2, Week 4, and Week 8"
              },
              {
                "measure": "Change from Baseline in Zung Self-Rating Anxiety Scale (SAS) Scores",
                "description": "The SAS is a 20-item self-report scale assessing anxiety symptoms. Each item is scored from 1 to 4, with positively worded items reverse-scored. The total raw score ranges from 20 to 80 and is multiplied by 1.25 to obtain a standardized score ranging from 25 to 100. Higher scores indicate more severe anxiety. Changes from baseline will be assessed at Weeks 2, 4, and 8, with negative changes indicating improvement.",
                "timeFrame": "Baseline, Week 2, Week 4, and Week 8."
              },
              {
                "measure": "Change from Baseline in Social Disability Screening Schedule (SDSS) Scores",
                "description": "SDSS is used to evaluate the daily functioning of patients. It consists of 10 items, with each item scored from 0 to 2. Higher total scores reflect a higher degree of social disability.",
                "timeFrame": "Baseline, Week 2, Week 4, and Week 8"
              },
              {
                "measure": "Frequency of Participants with Changes in medication Dosage",
                "description": "The study will record whether the daily dose of medication increased, remained unchanged, or decreased compared to the baseline.",
                "timeFrame": "Week 2, Week 4, and Week 8"
              }
            ],
            "otherOutcomes": [
              {
                "measure": "Changes in Functional Connectivity (FC), Regional Homogeneity (ReHo), and Amplitude of Low-Frequency Fluctuation (ALFF)",
                "description": "Resting-state fMRI will be used to assess changes in FC, ReHo, and ALFF before and after a single session of electroacupuncture (EA) or sham EA, or a duration-matched rest period in the waiting-list control group. Pre-to-post changes will be compared across the three groups.",
                "timeFrame": "Before and after a single EA/sham EA session or duration-matched rest period, on the same day."
              },
              {
                "measure": "Adverse Events",
                "description": "Adverse events such as bleeding, haematoma, or unbearable pain caused by the needle, as well as drug-induced nausea, vomiting or dizziness, will all be recorded.",
                "timeFrame": "Up to week 8"
              },
              {
                "measure": "Acupuncture Treatment Adherence",
                "description": "At the end of the 4-week intervention, treatment adherence will be assessed in the electroacupuncture and sham electroacupuncture groups. The adherence rate will be calculated for each participant as the number of treatment sessions attended divided by the total number of scheduled sessions (12), multiplied by 100%. Higher percentages indicate better adherence.",
                "timeFrame": "Week 4 (at the end of treatment)"
              }
            ]
          },
          "triage": "not added: narrow/acupuncture update without results"
        },
        {
          "nct_id": "NCT07767903",
          "title": "A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder",
          "status": {
            "statusVerifiedDate": "2026-10",
            "overallStatus": "RECRUITING",
            "expandedAccessInfo": {
              "hasExpandedAccess": false
            },
            "startDateStruct": {
              "date": "2026-08-06",
              "type": "ACTUAL"
            },
            "primaryCompletionDateStruct": {
              "date": "2028-10-25",
              "type": "ESTIMATED"
            },
            "completionDateStruct": {
              "date": "2028-11-01",
              "type": "ESTIMATED"
            },
            "studyFirstSubmitDate": "2026-08-11",
            "studyFirstSubmitQcDate": "2026-08-11",
            "studyFirstPostDateStruct": {
              "date": "2026-08-17",
              "type": "ACTUAL"
            },
            "lastUpdateSubmitDate": "2026-10-16",
            "lastUpdatePostDateStruct": {
              "date": "2026-10-20",
              "type": "ACTUAL"
            }
          },
          "design": {
            "studyType": "INTERVENTIONAL",
            "phases": [
              "PHASE3"
            ],
            "designInfo": {
              "allocation": "RANDOMIZED",
              "interventionModel": "PARALLEL",
              "primaryPurpose": "TREATMENT",
              "maskingInfo": {
                "masking": "TRIPLE",
                "whoMasked": [
                  "PARTICIPANT",
                  "INVESTIGATOR",
                  "OUTCOMES_ASSESSOR"
                ]
              }
            },
            "enrollmentInfo": {
              "count": 384,
              "type": "ESTIMATED"
            }
          },
          "conditions": {
            "conditions": [
              "Generalized Anxiety Disorder"
            ],
            "keywords": [
              "Generalized Anxiety Disorder",
              "GAD",
              "Anxiety"
            ]
          },
          "has_results": false,
          "triage": "existing tracked record; unchanged status/results"
        },
        {
          "nct_id": "NCT07879196",
          "title": "Two Sessions of Coach-Delivered Core Transformation for Distress and Well-Being",
          "status": {
            "statusVerifiedDate": "2026-10",
            "overallStatus": "NOT_YET_RECRUITING",
            "expandedAccessInfo": {
              "hasExpandedAccess": false
            },
            "startDateStruct": {
              "date": "2026-10-20",
              "type": "ESTIMATED"
            },
            "primaryCompletionDateStruct": {
              "date": "2027-05-31",
              "type": "ESTIMATED"
            },
            "completionDateStruct": {
              "date": "2028-06",
              "type": "ESTIMATED"
            },
            "studyFirstSubmitDate": "2026-10-10",
            "studyFirstSubmitQcDate": "2026-10-10",
            "studyFirstPostDateStruct": {
              "date": "2026-10-16",
              "type": "ACTUAL"
            },
            "lastUpdateSubmitDate": "2026-10-16",
            "lastUpdatePostDateStruct": {
              "date": "2026-10-21",
              "type": "ACTUAL"
            }
          },
          "design": {
            "studyType": "INTERVENTIONAL",
            "phases": [
              "NA"
            ],
            "designInfo": {
              "allocation": "RANDOMIZED",
              "interventionModel": "PARALLEL",
              "interventionModelDescription": "Two-arm, 1:1 randomized waitlist-controlled trial. Allocation uses minimization on location (United States vs. rest of world) and gender; each cohort has its own randomization. The immediate arm has two CT sessions in weeks 3-4. The delayed (waitlist) arm has no sessions until after their 2nd survey at about 4 weeks, then the same two sessions in weeks 5-6. The main comparison is at about 4 weeks. Both arms are then followed to 12 months after their second session. Sessions are given by coaches in training (Cohort 1) and certified coaches (Cohort 2).",
              "primaryPurpose": "OTHER",
              "maskingInfo": {
                "masking": "NONE",
                "maskingDescription": "Open label. Participants and coaches know when sessions start. For the analysis, the arms are exported under coded labels. The key is released to the analyst only after the primary results are final."
              }
            },
            "enrollmentInfo": {
              "count": 480,
              "type": "ESTIMATED"
            }
          },
          "conditions": {
            "conditions": [
              "Psychological Distress",
              "Psychological Well-being"
            ],
            "keywords": [
              "Core Transformation",
              "Coaching",
              "Online intervention",
              "Brief intervention",
              "Waitlist control",
              "Emotional wellbeing",
              "Daily functioning",
              "Neuro-Linguistic Programming",
              "Coach training",
              "Low mood",
              "Anxiousness",
              "Mental health",
              "psychological distress",
              "Patient Health Questionnaire-8",
              "Generalized Anxiety Disorder-7",
              "Stage II National Institutes of Health Stage Mode"
            ]
          },
          "has_results": false,
          "triage": "not added: mixed/symptom-selected or non-GAD scope; no results"
        },
        {
          "nct_id": "NCT07541443",
          "title": "Miles for Mental Health",
          "status": {
            "statusVerifiedDate": "2026-07",
            "overallStatus": "NOT_YET_RECRUITING",
            "expandedAccessInfo": {
              "hasExpandedAccess": false
            },
            "startDateStruct": {
              "date": "2026-11-10",
              "type": "ESTIMATED"
            },
            "primaryCompletionDateStruct": {
              "date": "2027-02-10",
              "type": "ESTIMATED"
            },
            "completionDateStruct": {
              "date": "2027-03-01",
              "type": "ESTIMATED"
            },
            "studyFirstSubmitDate": "2026-03-30",
            "studyFirstSubmitQcDate": "2026-04-14",
            "studyFirstPostDateStruct": {
              "date": "2026-04-21",
              "type": "ACTUAL"
            },
            "lastUpdateSubmitDate": "2026-10-21",
            "lastUpdatePostDateStruct": {
              "date": "2026-10-23",
              "type": "ACTUAL"
            }
          },
          "design": {
            "studyType": "INTERVENTIONAL",
            "phases": [
              "NA"
            ],
            "designInfo": {
              "allocation": "NA",
              "interventionModel": "SINGLE_GROUP",
              "primaryPurpose": "TREATMENT",
              "maskingInfo": {
                "masking": "NONE"
              }
            },
            "enrollmentInfo": {
              "count": 20,
              "type": "ESTIMATED"
            }
          },
          "conditions": {
            "conditions": [
              "Generalized Anxiety Disorder (GAD)",
              "Depressive and Anxiety Disorders"
            ],
            "keywords": [
              "cardiovascular fitness",
              "mental health",
              "anxiety",
              "depression",
              "group exercise"
            ]
          },
          "has_results": false,
          "triage": "not added: mixed/symptom-selected or non-GAD scope; no results"
        },
        {
          "nct_id": "NCT07786454",
          "title": "A Trial of the Safety and Tolerability of SEP-363856 in Adults With Generalized Anxiety Disorder",
          "status": {
            "statusVerifiedDate": "2026-10",
            "overallStatus": "RECRUITING",
            "expandedAccessInfo": {
              "hasExpandedAccess": false
            },
            "startDateStruct": {
              "date": "2026-10-08",
              "type": "ACTUAL"
            },
            "primaryCompletionDateStruct": {
              "date": "2029-05-26",
              "type": "ESTIMATED"
            },
            "completionDateStruct": {
              "date": "2029-06-02",
              "type": "ESTIMATED"
            },
            "studyFirstSubmitDate": "2026-08-20",
            "studyFirstSubmitQcDate": "2026-08-20",
            "studyFirstPostDateStruct": {
              "date": "2026-08-26",
              "type": "ACTUAL"
            },
            "lastUpdateSubmitDate": "2026-10-15",
            "lastUpdatePostDateStruct": {
              "date": "2026-10-20",
              "type": "ACTUAL"
            }
          },
          "design": {
            "studyType": "INTERVENTIONAL",
            "phases": [
              "PHASE3"
            ],
            "designInfo": {
              "allocation": "NA",
              "interventionModel": "SINGLE_GROUP",
              "primaryPurpose": "TREATMENT",
              "maskingInfo": {
                "masking": "NONE"
              }
            },
            "enrollmentInfo": {
              "count": 1120,
              "type": "ESTIMATED"
            }
          },
          "conditions": {
            "conditions": [
              "Generalized Anxiety Disorder"
            ],
            "keywords": [
              "Generalized Anxiety Disorder",
              "GAD",
              "Anxiety"
            ]
          },
          "has_results": false,
          "description": {
            "briefSummary": "This is a global, Phase 3, multicenter, open-label extension trial designed to evaluate the long-term safety, tolerability and efficacy of SEP-363856 administered at doses of 50 milligrams (mg) or 75 mg per day in adult participants with generalized anxiety disorder (GAD) over a treatment period of 26 weeks."
          },
          "eligibility": {
            "eligibilityCriteria": "Key Inclusion Criteria\n\n1. Male or female participants at least 18 years of age at the time of informed consent\n2. Completed one of the prior GAD Phase 3 studies involving SEP-363856 through Week 8 without discontinuation of trial intervention\n3. Able to continue treatment without interruption, and is considered by investigator to potentially benefit from SEP-363856\n4. Participant is willing and able to comply with study procedures and visit schedule\n5. i) Females of childbearing potential: negative pregnancy test and agreement to use acceptable contraception ii) Males: agreement to follow protocol-defined contraception and reproductive restrictions\n\nKey Exclusion Criteria\n\n1. Diagnosis other than GAD that is the primary focus of treatment\n2. Clinically significant psychiatric or medical condition that may interfere with study participation\n3. Lifetime history of meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for, or was diagnosed during the prior study with, a psychiatric disorder that would compromise accurate assessment of safety and efficacy outcomes\n4. Clinically significant abnormal laboratory values or ECG findings\n5. Significant suicide risk\n6. Substance use/positive drug screen\n7. Use of prohibited medications/therapies\n8. Known sensitivity to SEP-363856",
            "healthyVolunteers": false,
            "sex": "ALL",
            "minimumAge": "18 Years",
            "stdAges": [
              "ADULT",
              "OLDER_ADULT"
            ]
          },
          "outcomes": {
            "primaryOutcomes": [
              {
                "measure": "Number of Participants With Treatment-Emergent Adverse Events (TEAEs), Serious Adverse Events (SAEs), and TEAEs Leading to Discontinuation",
                "timeFrame": "Throughout the trial (up to Week 27)"
              }
            ],
            "secondaryOutcomes": [
              {
                "measure": "Change From Baseline in Hamilton Anxiety Rating Scale (HAM-A) Total Score",
                "description": "The HAM-A is a clinician-administered rating scale developed to quantify the severity of anxiety symptomatology. It consists of 14 items, each defined by a series of symptoms. Each item is scored on a 5-point Likert-type scale ranging from 0 (absent) to 4 (very severe). The total score ranges from 0 to 56, with higher scores indicating greater severity.",
                "timeFrame": "Baseline, Weeks 8, 14, and 26"
              },
              {
                "measure": "Change From Baseline in Clinical Global Impression-Severity (CGI-S) Score",
                "description": "The CGI-S is a clinician-rated assessment of the participant's current illness state on a 7-point Likert-type scale (1=normal, not at all ill; 7=among the most extremely ill participants), where a higher score is associated with greater illness severity. A decrease in value indicates improvement.",
                "timeFrame": "Baseline, Weeks 8, 14, and 26"
              }
            ],
            "otherOutcomes": [
              {
                "measure": "Percentage of Participants With Any Change in Laboratory Tests Values From Baseline",
                "timeFrame": "Baseline, Weeks 8, 20, and 26"
              },
              {
                "measure": "Percentage of Participants With Any Change in Potentially Clinically Relevant Vital Signs From Baseline",
                "description": "Vital signs including blood pressure, heart rate and body temperature will be recorded.",
                "timeFrame": "From Baseline up to Week 26"
              },
              {
                "measure": "Percentage of Participants With Any Change From Baseline in Weight, Body Mass Index (BMI) and Waist Circumference",
                "timeFrame": "Baseline, Weeks 8 and 26"
              },
              {
                "measure": "Percentage of Participants With Any Change From Baseline in 12-Lead Electrocardiogram (ECG)",
                "timeFrame": "From Baseline up to Week 26"
              },
              {
                "measure": "Number of Participants With Changes in Frequency and Severity of Suicidal Ideation and Suicidal Behavior as Measured by the Columbia-Suicide Severity Rating Scale (C-SSRS)",
                "description": "The C-SSRS is a clinician administered, interview-based rating scale which systematically assesses suicidal ideation, suicidal behavior and non-suicidal self-injurious behavior. The C-SSRS includes 'yes' or 'no' responses for assessment of suicidal behavior (preparatory acts or behavior, aborted attempt, interrupted attempt, suicidal behavior, completed suicide), suicidal ideation (wish to be dead, non-specific active suicidal thoughts, active suicidal ideation with any methods, active suicidal ideation with some intent, active suicidal ideation with specific plan and intent) and non-suicidal self-injurious behavior.",
                "timeFrame": "Up to Week 26"
              },
              {
                "measure": "Change From Baseline in Abnormal Involuntary Movement Scale (AIMS)",
                "description": "The AIMS total score commonly uses the sum of items 1-7 and ranges from 0 to 28 (0 = no abnormal movements; 28 = maximum severity on rated items); higher scores indicate more severe abnormal involuntary movements (worse outcome). A higher total score indicates more frequent or severe involuntary movements across multiple muscle groups.",
                "timeFrame": "Baseline, Weeks 8, 14, and 26"
              },
              {
                "measure": "Change From Baseline in Barnes Akathisia Rating Scale (BARS)",
                "description": "The BARS is a rating scale intended for the assessment of neuroleptic-induced akathisia. The global score ranges from 0 to 5 (0 = no akathisia; 5 = severe akathisia), and higher scores indicate more severe akathisia (worse outcome).",
                "timeFrame": "Baseline, Weeks 8, 14, and 26"
              },
              {
                "measure": "Change From Baseline in the Modified Simpson Angus Scale (MSAS)",
                "description": "The MSAS consists of a list of 10 symptoms of Parkinsonism (gait, arm dropping, shoulder shaking, elbow rigidity, wrist rigidity, head rotation, glabella tap, tremor, salivation, and akathisia). Each item will be rated on a 5-point scale, with a score of zero representing absence of symptoms, and a score of 4 representing a severe condition. The MSAS Total Score is the sum of the scores for all 10 items, ranging from 0 to 40. Higher scores indicate more severe movement disorder.",
                "timeFrame": "Baseline, Weeks 8, 14, and 26"
              }
            ]
          },
          "triage": "pipeline addition"
        },
        {
          "nct_id": "NCT07876453",
          "title": "Feasibility and Preliminary Outcomes of Compassion-Focused Group Therapy for Depression and Anxiety",
          "status": {
            "statusVerifiedDate": "2026-10",
            "overallStatus": "COMPLETED",
            "expandedAccessInfo": {
              "hasExpandedAccess": false
            },
            "startDateStruct": {
              "date": "2023-07-01",
              "type": "ACTUAL"
            },
            "primaryCompletionDateStruct": {
              "date": "2024-04-08",
              "type": "ACTUAL"
            },
            "completionDateStruct": {
              "date": "2024-04-08",
              "type": "ACTUAL"
            },
            "studyFirstSubmitDate": "2026-10-09",
            "studyFirstSubmitQcDate": "2026-10-09",
            "studyFirstPostDateStruct": {
              "date": "2026-10-15",
              "type": "ACTUAL"
            },
            "lastUpdateSubmitDate": "2026-10-16",
            "lastUpdatePostDateStruct": {
              "date": "2026-10-21",
              "type": "ACTUAL"
            }
          },
          "design": {
            "studyType": "INTERVENTIONAL",
            "phases": [
              "NA"
            ],
            "designInfo": {
              "allocation": "NA",
              "interventionModel": "SINGLE_GROUP",
              "interventionModelDescription": "This was an open-label, single-arm pilot study evaluating the feasibility and preliminary clinical outcomes of an 11-week compassion-focused group therapy intervention. All participants received the same intervention, delivered in three treatment groups. There was no randomization or control group. Clinical outcomes were assessed at baseline, post-treatment, and three-month follow-up.",
              "primaryPurpose": "TREATMENT",
              "maskingInfo": {
                "masking": "NONE"
              }
            },
            "enrollmentInfo": {
              "count": 21,
              "type": "ACTUAL"
            }
          },
          "conditions": {
            "conditions": [
              "Depression / Major Depressive Disorder",
              "Anxiety Disorder (Panic Disorder or GAD)"
            ],
            "keywords": [
              "Group psychotherapy",
              "Self-compassion",
              "Self-Criticism",
              "Compassion Focused Therapy",
              "Feasibility study"
            ]
          },
          "has_results": false,
          "triage": "not added: mixed/symptom-selected or non-GAD scope; no results"
        },
        {
          "nct_id": "NCT07706244",
          "title": "Preoperative Anxiety and One-year Patient-reported Outcomes in Orthopedic Surgery Patients Receiving Enhanced Recovery After Surgery or Conventional Care",
          "status": {
            "statusVerifiedDate": "2026-10",
            "overallStatus": "RECRUITING",
            "expandedAccessInfo": {
              "hasExpandedAccess": false
            },
            "startDateStruct": {
              "date": "2025-11-01",
              "type": "ACTUAL"
            },
            "primaryCompletionDateStruct": {
              "date": "2027-11-01",
              "type": "ESTIMATED"
            },
            "completionDateStruct": {
              "date": "2027-12",
              "type": "ESTIMATED"
            },
            "studyFirstSubmitDate": "2026-07-11",
            "studyFirstSubmitQcDate": "2026-07-11",
            "studyFirstPostDateStruct": {
              "date": "2026-07-15",
              "type": "ACTUAL"
            },
            "lastUpdateSubmitDate": "2026-10-21",
            "lastUpdatePostDateStruct": {
              "date": "2026-10-23",
              "type": "ACTUAL"
            }
          },
          "design": {
            "studyType": "OBSERVATIONAL",
            "patientRegistry": false,
            "designInfo": {
              "observationalModel": "COHORT",
              "timePerspective": "PROSPECTIVE"
            },
            "enrollmentInfo": {
              "count": 220,
              "type": "ESTIMATED"
            }
          },
          "conditions": {
            "conditions": [
              "Preoperative Anxiety",
              "Orthopedic Surgery",
              "Patient Reported Outcome (PRO)"
            ],
            "keywords": [
              "Enhanced Recovery After Surgery",
              "ERAS",
              "APAIS",
              "EQ-5D-5L",
              "Patient Global Impression of Change",
              "Quality of Life",
              "Cohort Study",
              "Perioperative Care"
            ]
          },
          "has_results": false,
          "triage": "not added: mixed/symptom-selected or non-GAD scope; no results"
        },
        {
          "nct_id": "NCT07892768",
          "title": "Effectiveness of Single-Session Acceptance and Commitment Therapy for Generalized Anxiety Symptoms.",
          "status": {
            "statusVerifiedDate": "2026-10",
            "overallStatus": "COMPLETED",
            "expandedAccessInfo": {
              "hasExpandedAccess": false
            },
            "startDateStruct": {
              "date": "2026-05-05",
              "type": "ACTUAL"
            },
            "primaryCompletionDateStruct": {
              "date": "2026-07-31",
              "type": "ACTUAL"
            },
            "completionDateStruct": {
              "date": "2026-07-31",
              "type": "ACTUAL"
            },
            "studyFirstSubmitDate": "2026-10-18",
            "studyFirstSubmitQcDate": "2026-10-18",
            "studyFirstPostDateStruct": {
              "date": "2026-10-23",
              "type": "ACTUAL"
            },
            "lastUpdateSubmitDate": "2026-10-18",
            "lastUpdatePostDateStruct": {
              "date": "2026-10-23",
              "type": "ACTUAL"
            }
          },
          "design": {
            "studyType": "INTERVENTIONAL",
            "phases": [
              "NA"
            ],
            "designInfo": {
              "allocation": "NA",
              "interventionModel": "SINGLE_GROUP",
              "interventionModelDescription": "Single-group, quasi-experimental, repeated-measures design. All participants received the same single-session intervention; no control or comparison group.",
              "primaryPurpose": "TREATMENT",
              "maskingInfo": {
                "masking": "NONE"
              }
            },
            "enrollmentInfo": {
              "count": 50,
              "type": "ACTUAL"
            }
          },
          "conditions": {
            "conditions": [
              "Generalised Anxiety Disorder",
              "Anxiety"
            ],
            "keywords": [
              "Acceptance and Commitment Therapy",
              "Single-Session Therapy",
              "Generalized Anxiety Symptoms",
              "University Students",
              "Psychological Inflexibility",
              "Pakistan",
              "GAD-7",
              "AAQ-II"
            ]
          },
          "has_results": false,
          "triage": "not added: mixed/symptom-selected or non-GAD scope; no results"
        },
        {
          "nct_id": "NCT07891624",
          "title": "Neural Mechanisms of Real-world Emotions and Internalizing",
          "status": {
            "statusVerifiedDate": "2026-10",
            "overallStatus": "RECRUITING",
            "expandedAccessInfo": {
              "hasExpandedAccess": false
            },
            "startDateStruct": {
              "date": "2026-08-24",
              "type": "ACTUAL"
            },
            "primaryCompletionDateStruct": {
              "date": "2030-11-30",
              "type": "ESTIMATED"
            },
            "completionDateStruct": {
              "date": "2030-11-30",
              "type": "ESTIMATED"
            },
            "studyFirstSubmitDate": "2026-10-16",
            "studyFirstSubmitQcDate": "2026-10-22",
            "studyFirstPostDateStruct": {
              "date": "2026-10-23",
              "type": "ACTUAL"
            },
            "lastUpdateSubmitDate": "2026-10-22",
            "lastUpdatePostDateStruct": {
              "date": "2026-10-23",
              "type": "ACTUAL"
            }
          },
          "design": {
            "studyType": "INTERVENTIONAL",
            "phases": [
              "NA"
            ],
            "designInfo": {
              "allocation": "NA",
              "interventionModel": "SINGLE_GROUP",
              "primaryPurpose": "BASIC_SCIENCE",
              "maskingInfo": {
                "masking": "NONE"
              }
            },
            "enrollmentInfo": {
              "count": 144,
              "type": "ESTIMATED"
            }
          },
          "conditions": {
            "conditions": [
              "Major Depression",
              "Generalized Anxiety",
              "Emotions"
            ]
          },
          "has_results": false,
          "triage": "not added: mixed/symptom-selected or non-GAD scope; no results"
        },
        {
          "nct_id": "NCT07123467",
          "title": "Cannabidiol-Assisted Learning for Managing Generalized Anxiety Disorder",
          "status": {
            "statusVerifiedDate": "2026-10",
            "overallStatus": "RECRUITING",
            "expandedAccessInfo": {
              "hasExpandedAccess": false
            },
            "startDateStruct": {
              "date": "2025-11-03",
              "type": "ACTUAL"
            },
            "primaryCompletionDateStruct": {
              "date": "2027-08-31",
              "type": "ESTIMATED"
            },
            "completionDateStruct": {
              "date": "2027-08-31",
              "type": "ESTIMATED"
            },
            "studyFirstSubmitDate": "2025-08-02",
            "studyFirstSubmitQcDate": "2025-08-13",
            "studyFirstPostDateStruct": {
              "date": "2025-08-14",
              "type": "ACTUAL"
            },
            "lastUpdateSubmitDate": "2026-10-20",
            "lastUpdatePostDateStruct": {
              "date": "2026-10-21",
              "type": "ACTUAL"
            }
          },
          "design": {
            "studyType": "INTERVENTIONAL",
            "phases": [
              "PHASE3"
            ],
            "designInfo": {
              "allocation": "RANDOMIZED",
              "interventionModel": "PARALLEL",
              "primaryPurpose": "TREATMENT",
              "maskingInfo": {
                "masking": "QUADRUPLE",
                "maskingDescription": "All participants, therapists, study staff, and outcomes assessors will be blinded to treatment assignment. Only the principal investigators hold the randomization and blinding key. Placebo is a matched oral solution designed to mimic EPIDIOLEX® in appearance, taste, and smell to maintain effective blinding.",
                "whoMasked": [
                  "PARTICIPANT",
                  "CARE_PROVIDER",
                  "INVESTIGATOR",
                  "OUTCOMES_ASSESSOR"
                ]
              }
            },
            "enrollmentInfo": {
              "count": 90,
              "type": "ESTIMATED"
            }
          },
          "conditions": {
            "conditions": [
              "Generalized Anxiety Disorder (GAD)",
              "Anxiety Disorders"
            ],
            "keywords": [
              "Cannabidiol",
              "EPIDIOLEX",
              "Cognitive Behavioral Therapy",
              "Generalized Anxiety Disorder",
              "functional magnetic resonance imaging"
            ]
          },
          "has_results": false,
          "description": {
            "briefSummary": "This randomized, double-blind, placebo-controlled clinical trial investigates the use of Food and Drug Administration (FDA)-approved cannabidiol (EPIDIOLEX®) as an adjunct to cognitive behavioral therapy (CBT) in adults with generalized anxiety disorder (GAD). The study aims to evaluate whether cannabidiol-assisted CBT enhances emotion regulation via dorsomedial prefrontal cortex (dmPFC) activation and improves anxiety symptom outcomes compared to CBT with placebo.",
            "detailedDescription": "The study is a randomized, double-blind, placebo-controlled clinical trial evaluating cannabidiol (CBD) as an adjunct to cognitive behavioral therapy (CBT) for treating generalized anxiety disorder (GAD) in adults aged 18-45. Participants will be randomly assigned to one of four arms: (1) Brief CBT with moderate-dose EPIDIOLEX® (10 milligrams(mg)/kilograms(kg)/day), (2) Brief CBT with low-dose EPIDIOLEX® (5 mg/kg/day), (3) Brief CBT with matched placebo with dosing matched to the moderate-dose EPIDIOLEX®, or 4) Brief CBT with matched placebo with dosing matched to the low-dose EPIDIOLEX®. The trial uses a neurobiologically informed experimental medicine approach to evaluate target engagement in the dorsomedial prefrontal cortex (dmPFC) during an emotion regulation functional magnetic resonance imaging (fMRI) task before and after treatment. Primary outcomes include change in dmPFC activation, while secondary outcomes include anxiety symptom severity, treatment tolerability, and plasma concentrations of cannabidiol and related biomarkers."
          },
          "eligibility": {
            "eligibilityCriteria": "Inclusion Criteria:\n\n* Right-handed\n* Age 18-45 years at enrollment\n* Able to consent to the study\n* Agree to adhere to lifestyle considerations throughout study duration\n* Generally medically and neurologically healthy, including no evidence of intellectual disability or serious cognitive impairment\n* Have a current generalized anxiety disorder (GAD) diagnosis according to the The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria and/or total scores ≥ 8 on the 7-Item Generalized Anxiety Disorders Scale (GAD-7)\n\nExclusion Criteria:\n\n* Clinically significant medical or neurologic condition or neurocognitive dysfunction that would affect function and/or task performance and/or interfere with the study protocol\n* Any current (or within past 2 months) medical condition requiring medication that would interact with cannabidiol or interfere with the study protocol\n* Risk of harm to self or others that requires immediate intervention\n* Presence of contraindications, current or past allergic or adverse reaction, or known sensitivity to cannabinoid-like substances or components of EPIDIOLEX®\n* Positive drug screen or alcohol breathalyzer\n* Unwilling/unable to sign informed consent document\n* Currently pregnant (positive pregnancy test), planning pregnancy, or lactating (women),\n* Under 18 or over 45 years of age\n* Traumatic brain injury, as defined by The American Congress of Rehabilitation as a person who has had a traumatically induced physiological disruption of brain function (i.e., the head being struck, the head striking an object, and/or the brain undergoing an acceleration/deceleration movement \\[i.e., whiplash\\] without direct external trauma to the head), as manifested by at least one of the following: any loss of consciousness; any loss of memory for events immediately before or after the injury; any alteration in mental status at the time of the incident; or focal neurological deficits that may or may not be transient)\n* Inability to tolerate small, enclosed spaces without anxiety (e.g. claustrophobia), as determined by self-report and/or a preliminary session in a mock scanner\n* Presence of ferrous-containing metals within the body (e.g., aneurysm clips, shrapnel/retained particles)\n* Receiving concurrent psychotherapy or have received psychotherapy, including for research purposes, within the past year\n* Current moderate or severe alcohol/drug use disorder or in the past 8 weeks\n* Current or past diagnosis of bipolar and other related disorders, schizophrenia spectrum, or other psychotic disorders;\n* GAD-7 score \\< 8\n* Use of medications known to have severe drug interactions with cannabidiol or that are strong inducers of cytochrome P450 3A4 (CYP3A4) or cytochrome P450 2C19 (CYP2C19)\n* Visual impairment\n* Baseline labs 3 times outside of normal range\n* Use of as needed anti-anxiety medications (e.g., benzodiazepines), unstable dose of other psychoactive drug (i.e., \\< 4 weeks), or intention to start new treatment during this trial\n* Current or past-month use of cannabis, or a tetrahydrocannabinol (THC) or cannabidiol-containing product (self-report and urine drug screen)\n* Current or past-month coronavirus disease 2019 (COVID-19) diagnosis or febrile illness\n* Treatment with another investigational drug or intervention within the past month\n* Difficulty with or inability to comply with the complete clinical trial.",
            "healthyVolunteers": false,
            "sex": "ALL",
            "minimumAge": "18 Years",
            "maximumAge": "45 Years",
            "stdAges": [
              "ADULT"
            ]
          },
          "outcomes": {
            "primaryOutcomes": [
              {
                "measure": "Change in dorsomedial prefrontal cortex activation when reappraising negative images",
                "description": "Within-participant change in dorsomedial prefrontal cortex (dmPFC) activation will be calculated as post-treatment minus baseline values during an explicit emotion regulation task (Reappraise \\> Maintain contrast). Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Baseline to post-treatment (~Week 5)"
              }
            ],
            "secondaryOutcomes": [
              {
                "measure": "Post-treatment dorsomedial prefrontal cortex activation when reappraising negative images",
                "description": "Post-treatment dorsomedial prefrontal cortex (dmPFC) activation during an explicit emotion regulation task (Reappraise \\> Maintain contrast). Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Post-treatment (~Week 5)"
              },
              {
                "measure": "Post-treatment amygdala activation when reappraising negative images",
                "description": "Post-treatment amygdala activation during an explicit emotion regulation task (Reappraise \\> Maintain contrast). Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Post-treatment (~Week 5)"
              },
              {
                "measure": "Change in amygdala activation when reappraising negative images",
                "description": "Within-participant change in amygdala activation will be calculated as post-treatment minus baseline values during an explicit emotion regulation task (Reappraise \\> Maintain contrast). Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Baseline to post-treatment (~Week 5)"
              },
              {
                "measure": "Post-treatment hippocampal activation when reappraising negative images",
                "description": "Post-treatment hippocampal activation during an explicit emotion regulation task (Reappraise \\> Maintain contrast). Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Post-treatment (~Week 5)"
              },
              {
                "measure": "Change in hippocampal activation when reappraising negative images",
                "description": "Within-participant change in hippocampal activation will be calculated as post-treatment minus baseline values during an explicit emotion regulation task (Reappraise \\> Maintain contrast). Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Baseline to post-treatment (~Week 5)"
              },
              {
                "measure": "Post-treatment inferior frontal gyrus activation when reappraising negative stimuli",
                "description": "Post-treatment inferior frontal gyrus activation during an explicit emotion regulation task (Reappraise \\> Maintain contrast). Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Post-treatment (~Week 5)"
              },
              {
                "measure": "Change in inferior frontal gyrus activation when reappraising negative images",
                "description": "Within-participant change in inferior frontal gyrus activation will be calculated as post-treatment minus baseline values during an explicit emotion regulation task (Reappraise \\> Maintain contrast). Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Baseline to post-treatment (~Week 5)"
              },
              {
                "measure": "Post-treatment anterior insula activation when reappraising negatives images",
                "description": "Post-treatment anterior insula activation during an explicit emotion regulation task (Reappraise \\> Maintain contrast). Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Post-treatment (~Week 5)"
              },
              {
                "measure": "Change in anterior insula activation when reappraising negative images",
                "description": "Within-participant change in anterior insula activation will be calculated as post-treatment minus baseline values during an explicit emotion regulation task (Reappraise \\> Maintain contrast). Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Baseline to post-treatment (~Week 5)"
              },
              {
                "measure": "Change in plasma concentration of anandamide from baseline to post-treatment",
                "description": "Plasma anandamide levels will be measured via liquid chromatography-tandem mass spectrometry (LC-MS/MS) at baseline and post-treatment. Change will be calculated as post-treatment minus baseline values (nanogram per milliliter).",
                "timeFrame": "Baseline and post-treatment (~Week 5)"
              },
              {
                "measure": "Change in plasma concentration of 2-arachidonoylglycerol (2-AG) from baseline to post-treatment",
                "description": "Plasma 2-arachidonoylglycerol (2-AG) levels will be measured via liquid chromatography-tandem mass spectrometry (LC-MS/MS) at baseline and post-treatment. Change will be calculated as post-treatment minus baseline values (nanogram per milliliter).",
                "timeFrame": "Baseline and post-treatment (~Week 5)"
              },
              {
                "measure": "Change in plasma concentration of cannabidiol from baseline to post-treatment",
                "description": "Plasma cannabidiol levels will be measured via liquid chromatography-tandem mass spectrometry (LC-MS/MS) at baseline and post-treatment. Change will be calculated as post-treatment minus baseline values (nanogram per milliliter).",
                "timeFrame": "Baseline and post-treatment (~Week 5)"
              },
              {
                "measure": "Change in plasma concentration of 7-hydroxy-cannabidiol (7-OH-CBD) from baseline to post-treatment",
                "description": "7-hydroxy-cannabidiol (7-OH-CBD; active metabolite) levels will be measured via liquid chromatography-tandem mass spectrometry (LC-MS/MS) at baseline and post-treatment. Change will be calculated as post-treatment minus baseline values (nanogram per milliliter).",
                "timeFrame": "Baseline and post-treatment (~Week 5)"
              },
              {
                "measure": "Post-treatment dorsomedial prefrontal cortex activation during implicit emotion regulation",
                "description": "Post-treatment dorsomedial prefrontal cortex (dmPFC) activation during an implicit emotion regulation task. Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Post-treatment (~Week 5)"
              },
              {
                "measure": "Change in dorsomedial prefrontal cortex activation during implicit emotion regulation",
                "description": "Within-participant change in dorsomedial prefrontal cortex (dmPFC) activation will be calculated as post-treatment minus baseline values during an implicit emotion regulation task. Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Baseline to post-treatment (~Week 5)"
              },
              {
                "measure": "Post-treatment ventromedial prefrontal cortex activation during implicit emotion regulation",
                "description": "Post-treatment ventromedial prefrontal cortex (vmPFC) activation during implicit emotion regulation. Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Post-treatment (~Week 5)"
              },
              {
                "measure": "Change in ventromedial prefrontal cortex activation during implicit emotion regulation",
                "description": "Within-participant change in ventromedial prefrontal cortex (vmPFC) activation will be calculated as post-treatment minus baseline values during an implicit emotion regulation task. Measured using blood-oxygen-level-dependent (BOLD) signal from multi-echo functional magnetic resonance imaging (fMRI).",
                "timeFrame": "Baseline to post-treatment (~Week 5)"
              },
              {
                "measure": "Change in depressive symptom severity",
                "description": "Change in depressive symptom severity will be assessed using the 9-item Patient Health Questionnaire (PHQ-9), a validated self-report instrument that measures symptoms of depression over the past two weeks. Each item is rated on a 0-3 scale, producing a total score ranging from 0 to 27, with higher scores indicating greater severity. Scores will be collected at baseline and post-treatment. Change will be calculated as post-treatment minus baseline score.",
                "timeFrame": "Baseline and post-treatment (~Week 5)"
              }
            ]
          },
          "triage": "pipeline addition"
        }
      ]
    },
    {
      "query": {
        "query.cond": "Generalized Anxiety Disorder",
        "filter.advanced": "AREA[ResultsFirstPostDate]RANGE[2026-10-17, 2026-10-24]",
        "pageSize": 1000,
        "format": "json",
        "countTotal": "true"
      },
      "total_count": 0,
      "records": []
    }
  ],
  "ctgov_comparison": {
    "previous_snapshot": "2026-10-17",
    "previous_ids": 43,
    "markdown_ids_checked": 45,
    "status_changes": [],
    "results_changes": [],
    "updated_existing_record": "NCT07767903: last update 2026-10-20; status/enrollment/hasResults unchanged",
    "note": "Two additional identifiers found only in the preceding LOG (healthy-adult and mixed-diagnosis exclusions) were also checked."
  },
  "isrctn": {
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        "Journal Article"
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      "publication_types": [
        "Journal Article"
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        "Journal Article"
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        "Journal Article"
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      "title": "Amitriptyline Therapy and  CYP2D6  and  CYP2C19  Genotype",
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      "title": "Children's Cognitive Abilities Moderate Parent/Teacher Agreement on Internalizing and Externalizing Psychopathology.",
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        "Journal Article"
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      "title": "Mapping mental health complexity in esports: an exploratory psychosocial network approach.",
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        "Journal Article"
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  "verification": {
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    "new_doi_only_document": "10.46995/gpc_641",
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}