{ "condition": "fibromyalgia", "date": "2026-10-30", "date_from": "2026-10-23", "date_to": "2026-10-30", "pubmed": { "broad_dp": { "query": "fibromyalgia[tiab] AND 2026/10/23:2026/10/30[dp]", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+2026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D&retmode=json&retmax=500", "count": "12", "translation": "\"fibromyalgia\"[Title/Abstract] AND 2026/10/23:2026/10/30[Date - Publication]", "ids": [ "42955062", "42954876", "42949896", "42946199", "42933805", "42929762", "42926172", "42925908", "42921774", "42921698", "42912713", "42821997" ], "warnings": {}, "error": null }, "broad_edat": { "query": "fibromyalgia[tiab] AND 2026/10/23:2026/10/30[edat]", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D&retmode=json&retmax=500", "count": "22", "translation": "\"fibromyalgia\"[Title/Abstract] AND 2026/10/23:2026/10/30[Date - Entry]", "ids": [ "42955062", "42954876", "42953876", "42949896", "42946199", "42945611", "42942118", "42940523", "42936724", "42933805", "42930870", "42930518", "42929762", "42929722", "42926172", "42925908", "42924382", "42921774", "42921698", "42914549", "42912713", "42910234" ], "warnings": {}, "error": null }, "criteria_epi": { "query": "fibromyalgia[tiab] AND (diagnos* OR criteria OR prevalence OR incidence OR burden OR epidemiolog*) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28diagnos%2A+OR+criteria+OR+prevalence+OR+incidence+OR+burden+OR+epidemiolog%2A%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "15", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"diagnos*\"[All Fields] OR (\"criteria s\"[All Fields] OR \"criterias\"[All Fields] OR \"standards\"[MeSH Subheading] OR \"standards\"[All Fields] OR \"criteria\"[All Fields]) OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields]) OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR \"epidemiolog*\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42954876", "42953876", "42942118", "42940523", "42936724", "42933805", "42930870", "42930518", "42929722", "42926172", "42924382", "42921698", "42914549", "42912713", "42821997" ], "warnings": {}, "error": null }, "central": { "query": "fibromyalgia[tiab] AND (central sensitization OR neuroimag* OR brain OR glia OR nociplastic) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28central+sensitization+OR+neuroimag%2A+OR+brain+OR+glia+OR+nociplastic%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "7", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"central sensitisation\"[All Fields] OR \"central nervous system sensitization\"[MeSH Terms] OR (\"central\"[All Fields] AND \"nervous\"[All Fields] AND \"system\"[All Fields] AND \"sensitization\"[All Fields]) OR \"central nervous system sensitization\"[All Fields] OR (\"central\"[All Fields] AND \"sensitization\"[All Fields]) OR \"central sensitization\"[All Fields] OR \"neuroimag*\"[All Fields] OR (\"brain\"[MeSH Terms] OR \"brain\"[All Fields] OR \"brains\"[All Fields] OR \"brain s\"[All Fields]) OR (\"neuroglia\"[MeSH Terms] OR \"neuroglia\"[All Fields] OR \"glia\"[All Fields]) OR \"nociplastic\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42954876", "42942118", "42940523", "42930518", "42926172", "42921698", "42910234" ], "warnings": {}, "error": null }, "peripheral": { "query": "fibromyalgia[tiab] AND (small fiber OR small fibre OR peripheral OR nociceptor*) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28small+fiber+OR+small+fibre+OR+peripheral+OR+nociceptor%2A%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "3", "translation": "\"fibromyalgia\"[Title/Abstract] AND (((\"small\"[Journal] OR \"small\"[All Fields]) AND (\"fiber\"[All Fields] OR \"fiber s\"[All Fields] OR \"fiberized\"[All Fields] OR \"fibers\"[All Fields] OR \"fibre\"[All Fields] OR \"fibre s\"[All Fields] OR \"fibres\"[All Fields])) OR ((\"small\"[Journal] OR \"small\"[All Fields]) AND (\"fiber\"[All Fields] OR \"fiber s\"[All Fields] OR \"fiberized\"[All Fields] OR \"fibers\"[All Fields] OR \"fibre\"[All Fields] OR \"fibre s\"[All Fields] OR \"fibres\"[All Fields])) OR (\"peripheral\"[All Fields] OR \"peripherally\"[All Fields] OR \"peripherals\"[All Fields] OR \"periphereal\"[All Fields] OR \"peripheric\"[All Fields] OR \"peripherically\"[All Fields]) OR \"nociceptor*\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42955062", "42953876", "42921698" ], "warnings": {}, "error": null }, "immune": { "query": "fibromyalgia[tiab] AND (autoimmun* OR antibody OR inflammation OR cytokine*) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28autoimmun%2A+OR+antibody+OR+inflammation+OR+cytokine%2A%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "1", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"autoimmun*\"[All Fields] OR (\"antibodie\"[All Fields] OR \"antibodies\"[Supplementary Concept] OR \"antibodies\"[All Fields] OR \"antibodies\"[MeSH Terms] OR \"antibody s\"[All Fields] OR \"antibodys\"[All Fields] OR \"immunoglobulins\"[Supplementary Concept] OR \"immunoglobulins\"[All Fields] OR \"antibody\"[All Fields] OR \"immunoglobulins\"[MeSH Terms]) OR (\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation s\"[All Fields]) OR \"cytokine*\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42926172" ], "warnings": {}, "error": null }, "genetics_omics": { "query": "fibromyalgia[tiab] AND (genetic* OR GWAS OR microbiom* OR metabolom* OR omics) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28genetic%2A+OR+GWAS+OR+microbiom%2A+OR+metabolom%2A+OR+omics%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "1", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"genetic*\"[All Fields] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields]) OR \"microbiom*\"[All Fields] OR \"metabolom*\"[All Fields] OR (\"omics\"[Journal] OR \"omics\"[All Fields])) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42926172" ], "warnings": {}, "error": null }, "sleep_fatigue_cog": { "query": "fibromyalgia[tiab] AND (sleep OR fatigue OR cognition OR cognitive) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28sleep+OR+fatigue+OR+cognition+OR+cognitive%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "9", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"sleep\"[MeSH Terms] OR \"sleep\"[All Fields] OR \"sleeping\"[All Fields] OR \"sleeps\"[All Fields] OR \"sleep s\"[All Fields] OR (\"fatiguability\"[All Fields] OR \"fatiguable\"[All Fields] OR \"fatigue\"[MeSH Terms] OR \"fatigue\"[All Fields] OR \"fatigued\"[All Fields] OR \"fatigues\"[All Fields] OR \"fatiguing\"[All Fields] OR \"fatigueability\"[All Fields]) OR (\"cognition\"[MeSH Terms] OR \"cognition\"[All Fields] OR \"cognitions\"[All Fields] OR \"cognitive\"[All Fields] OR \"cognitively\"[All Fields] OR \"cognitives\"[All Fields]) OR (\"cognition\"[MeSH Terms] OR \"cognition\"[All Fields] OR \"cognitions\"[All Fields] OR \"cognitive\"[All Fields] OR \"cognitively\"[All Fields] OR \"cognitives\"[All Fields])) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42955062", "42954876", "42946199", "42945611", "42942118", "42925908", "42921698", "42914549", "42912713" ], "warnings": {}, "error": null }, "overlap": { "query": "fibromyalgia[tiab] AND (comorbid* OR overlap OR migraine OR irritable bowel OR ME/CFS) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28comorbid%2A+OR+overlap+OR+migraine+OR+irritable+bowel+OR+ME%2FCFS%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "8", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"comorbid*\"[All Fields] OR (\"overlap\"[All Fields] OR \"overlapped\"[All Fields] OR \"overlapping\"[All Fields] OR \"overlappings\"[All Fields] OR \"overlaps\"[All Fields]) OR (\"migrain\"[All Fields] OR \"migraine disorders\"[MeSH Terms] OR (\"migraine\"[All Fields] AND \"disorders\"[All Fields]) OR \"migraine disorders\"[All Fields] OR \"migraine\"[All Fields] OR \"migraines\"[All Fields] OR \"migraine s\"[All Fields] OR \"migraineous\"[All Fields] OR \"migrainers\"[All Fields] OR \"migrainous\"[All Fields]) OR (\"irritable bowel syndrome\"[MeSH Terms] OR (\"irritable\"[All Fields] AND \"bowel\"[All Fields] AND \"syndrome\"[All Fields]) OR \"irritable bowel syndrome\"[All Fields] OR (\"irritable\"[All Fields] AND \"bowel\"[All Fields]) OR \"irritable bowel\"[All Fields]) OR \"me cfs\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42953876", "42942118", "42940523", "42936724", "42930518", "42929722", "42921774", "42921698" ], "warnings": {}, "error": null }, "pharm": { "query": "fibromyalgia[tiab] AND (drug OR pharmacolog* OR duloxetine OR pregabalin OR cyclobenzaprine OR naltrexone OR cannabinoid*) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28drug+OR+pharmacolog%2A+OR+duloxetine+OR+pregabalin+OR+cyclobenzaprine+OR+naltrexone+OR+cannabinoid%2A%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "8", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"drug\"[All Fields] OR \"pharmacolog*\"[All Fields] OR (\"duloxetin\"[All Fields] OR \"duloxetine hydrochloride\"[Supplementary Concept] OR \"duloxetine hydrochloride\"[All Fields] OR \"duloxetine\"[All Fields] OR \"duloxetine hydrochloride\"[MeSH Terms] OR (\"duloxetine\"[All Fields] AND \"hydrochloride\"[All Fields]) OR \"duloxetine s\"[All Fields]) OR (\"pregabalin\"[Supplementary Concept] OR \"pregabalin\"[All Fields] OR \"pregabalin\"[MeSH Terms] OR \"pregabaline\"[All Fields] OR \"pregabalin s\"[All Fields]) OR (\"cyclobenzaprine\"[Supplementary Concept] OR \"cyclobenzaprine\"[All Fields]) OR (\"naltrexone\"[Supplementary Concept] OR \"naltrexone\"[All Fields] OR \"naltrexon\"[All Fields] OR \"naltrexone\"[MeSH Terms] OR \"naltrexone s\"[All Fields]) OR \"cannabinoid*\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42955062", "42953876", "42949896", "42946199", "42940523", "42926172", "42925908", "42921774" ], "warnings": {}, "error": null }, "nonpharm": { "query": "fibromyalgia[tiab] AND (exercise OR physical therapy OR cognitive behavioral OR CBT OR ACT OR acupuncture OR neuromodulation) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28exercise+OR+physical+therapy+OR+cognitive+behavioral+OR+CBT+OR+ACT+OR+acupuncture+OR+neuromodulation%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "7", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields] OR (\"physical therapy modalities\"[MeSH Terms] OR (\"physical\"[All Fields] AND \"therapy\"[All Fields] AND \"modalities\"[All Fields]) OR \"physical therapy modalities\"[All Fields] OR (\"physical\"[All Fields] AND \"therapy\"[All Fields]) OR \"physical therapy\"[All Fields]) OR ((\"cognition\"[MeSH Terms] OR \"cognition\"[All Fields] OR \"cognitions\"[All Fields] OR \"cognitive\"[All Fields] OR \"cognitively\"[All Fields] OR \"cognitives\"[All Fields]) AND (\"behavior s\"[All Fields] OR \"behaviorally\"[All Fields] OR \"behaviour\"[All Fields] OR \"behavior\"[MeSH Terms] OR \"behavior\"[All Fields] OR \"behavioural\"[All Fields] OR \"behavioral\"[All Fields] OR \"behaviourally\"[All Fields] OR \"behaviours\"[All Fields] OR \"behaviors\"[All Fields] OR \"pattern\"[All Fields] OR \"pattern s\"[All Fields] OR \"patternability\"[All Fields] OR \"patternable\"[All Fields] OR \"patterned\"[All Fields] OR \"patterning\"[All Fields] OR \"patternings\"[All Fields] OR \"patterns\"[All Fields])) OR \"CBT\"[All Fields] OR \"ACT\"[All Fields] OR (\"acupunctural\"[All Fields] OR \"acupuncture\"[MeSH Terms] OR \"acupuncture\"[All Fields] OR \"acupuncture therapy\"[MeSH Terms] OR (\"acupuncture\"[All Fields] AND \"therapy\"[All Fields]) OR \"acupuncture therapy\"[All Fields] OR \"acupuncture s\"[All Fields] OR \"acupunctured\"[All Fields] OR \"acupunctures\"[All Fields] OR \"acupuncturing\"[All Fields]) OR (\"neuromodulate\"[All Fields] OR \"neuromodulating\"[All Fields] OR \"neuromodulation\"[All Fields] OR \"neuromodulations\"[All Fields] OR \"neuromodulative\"[All Fields] OR \"neurotransmitter agents\"[Pharmacological Action] OR \"neurotransmitter agents\"[Supplementary Concept] OR \"neurotransmitter agents\"[All Fields] OR \"neuromodulator\"[All Fields] OR \"neurotransmitter agents\"[MeSH Terms] OR (\"neurotransmitter\"[All Fields] AND \"agents\"[All Fields]) OR \"neuromodulators\"[All Fields])) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42955062", "42954876", "42945611", "42926172", "42925908", "42921698", "42912713" ], "warnings": {}, "error": null }, "guide_safety": { "query": "fibromyalgia[tiab] AND (guideline OR consensus OR safety OR adverse OR opioid OR suicid*) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28guideline+OR+consensus+OR+safety+OR+adverse+OR+opioid+OR+suicid%2A%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "2", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"guideline\"[Publication Type] OR \"guidelines as topic\"[MeSH Terms] OR \"guideline\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]) OR (\"adverse\"[All Fields] OR \"adversely\"[All Fields] OR \"adverses\"[All Fields]) OR (\"analgesics opioid\"[Pharmacological Action] OR \"analgesics opioid\"[Supplementary Concept] OR \"analgesics opioid\"[All Fields] OR \"opioid\"[All Fields] OR \"analgesics, opioid\"[MeSH Terms] OR (\"analgesics\"[All Fields] AND \"opioid\"[All Fields]) OR \"opioid analgesics\"[All Fields] OR \"opioids\"[All Fields] OR \"opioid s\"[All Fields]) OR \"suicid*\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42949896", "42946199" ], "warnings": {}, "error": null }, "outcomes_bio": { "query": "fibromyalgia[tiab] AND (outcome* OR FIQR OR FIQ OR biomarker* OR classifier) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28outcome%2A+OR+FIQR+OR+FIQ+OR+biomarker%2A+OR+classifier%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "8", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"outcome*\"[All Fields] OR \"FIQR\"[All Fields] OR \"FIQ\"[All Fields] OR \"biomarker*\"[All Fields] OR (\"classifiable\"[All Fields] OR \"classification\"[MeSH Terms] OR \"classification\"[All Fields] OR \"classified\"[All Fields] OR \"classify\"[All Fields] OR \"classifying\"[All Fields] OR \"classifier\"[All Fields] OR \"classifier s\"[All Fields] OR \"classifiers\"[All Fields] OR \"classifies\"[All Fields])) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42953876", "42940523", "42933805", "42926172", "42925908", "42924382", "42914549", "42821997" ], "warnings": {}, "error": null }, "patient": { "query": "fibromyalgia[tiab] AND (patient experience OR stigma OR qualitative OR advocacy) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28patient+experience+OR+stigma+OR+qualitative+OR+advocacy%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "2", "translation": "\"fibromyalgia\"[Title/Abstract] AND (((\"patient s\"[All Fields] OR \"patients\"[MeSH Terms] OR \"patients\"[All Fields] OR \"patient\"[All Fields] OR \"patients s\"[All Fields]) AND (\"experience\"[All Fields] OR \"experience s\"[All Fields] OR \"experiences\"[All Fields])) OR (\"social stigma\"[MeSH Terms] OR (\"social\"[All Fields] AND \"stigma\"[All Fields]) OR \"social stigma\"[All Fields] OR \"stigma\"[All Fields] OR \"stigmas\"[All Fields] OR \"stigma s\"[All Fields]) OR (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields]) OR (\"advocacies\"[All Fields] OR \"advocacy\"[All Fields] OR \"advocacy s\"[All Fields])) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42929722", "42912713" ], "warnings": {}, "error": null }, "cochrane_broad": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_chronic_pain": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"chronic pain\" OR nociplastic OR \"chronic primary pain\") AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28%22chronic+pain%22+OR+nociplastic+OR+%22chronic+primary+pain%22%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"chronic pain\"[All Fields] OR \"nociplastic\"[All Fields] OR \"chronic primary pain\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "systematic_reviews": { "query": "fibromyalgia[tiab] AND (systematic review[pt] OR meta-analysis[pt] OR \"systematic review\"[tiab] OR meta-analy*[tiab]) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28systematic+review%5Bpt%5D+OR+meta-analysis%5Bpt%5D+OR+%22systematic+review%22%5Btiab%5D+OR+meta-analy%2A%5Btiab%5D%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "2", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"systematic review\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"systematic review\"[Title/Abstract] OR \"meta analy*\"[Title/Abstract]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42926172", "42924382" ], "warnings": {}, "error": null }, "rcts": { "query": "fibromyalgia[tiab] AND (randomized controlled trial[pt] OR randomi*[tiab]) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Btiab%5D+AND+%28randomized+controlled+trial%5Bpt%5D+OR+randomi%2A%5Btiab%5D%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "4", "translation": "\"fibromyalgia\"[Title/Abstract] AND (\"randomized controlled trial\"[Publication Type] OR \"randomi*\"[Title/Abstract]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42946199", "42925908", "42924382", "42914549" ], "warnings": {}, "error": null }, "guidelines_pt": { "query": "fibromyalgia AND (guideline[pt] OR practice guideline[pt] OR consensus[tiab] OR recommendation*[tiab]) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia+AND+%28guideline%5Bpt%5D+OR+practice+guideline%5Bpt%5D+OR+consensus%5Btiab%5D+OR+recommendation%2A%5Btiab%5D%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "2", "translation": "(\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields]) AND (\"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR \"consensus\"[Title/Abstract] OR \"recommendation*\"[Title/Abstract]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42946199", "42924382" ], "warnings": {}, "error": null }, "goebel_fcrn": { "query": "(rozanolixizumab OR FcRn OR efgartigimod OR nipocalimab) AND (fibromyalgia OR \"chronic pain\")", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28rozanolixizumab+OR+FcRn+OR+efgartigimod+OR+nipocalimab%29+AND+%28fibromyalgia+OR+%22chronic+pain%22%29&retmode=json&retmax=500", "count": "7", "translation": "(\"rozanolixizumab\"[Supplementary Concept] OR \"rozanolixizumab\"[All Fields] OR \"FcRn\"[All Fields] OR (\"efgartigimod alfa\"[Supplementary Concept] OR \"efgartigimod alfa\"[All Fields] OR \"efgartigimod\"[All Fields]) OR (\"nipocalimab\"[Supplementary Concept] OR \"nipocalimab\"[All Fields])) AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic pain\"[All Fields])", "ids": [ "42748952", "42633339", "41284548", "40612406", "37656420", "31387871", "28800217" ], "warnings": {}, "error": null }, "mesh_broad": { "query": "fibromyalgia[mh] AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia%5Bmh%5D+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "4", "translation": "\"fibromyalgia\"[MeSH Terms] AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [ "42936724", "42930518", "42924382", "42921774" ], "warnings": {}, "error": null }, "cochrane_criteria_epi": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (diagnos* OR criteria OR prevalence OR incidence OR burden OR epidemiolog*) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28diagnos%2A+OR+criteria+OR+prevalence+OR+incidence+OR+burden+OR+epidemiolog%2A%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (\"diagnos*\"[All Fields] OR (\"criteria s\"[All Fields] OR \"criterias\"[All Fields] OR \"standards\"[MeSH Subheading] OR \"standards\"[All Fields] OR \"criteria\"[All Fields]) OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields]) OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR \"epidemiolog*\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_central": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (central sensitization OR neuroimag* OR brain OR glia OR nociplastic) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28central+sensitization+OR+neuroimag%2A+OR+brain+OR+glia+OR+nociplastic%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (\"central sensitisation\"[All Fields] OR \"central nervous system sensitization\"[MeSH Terms] OR (\"central\"[All Fields] AND \"nervous\"[All Fields] AND \"system\"[All Fields] AND \"sensitization\"[All Fields]) OR \"central nervous system sensitization\"[All Fields] OR (\"central\"[All Fields] AND \"sensitization\"[All Fields]) OR \"central sensitization\"[All Fields] OR \"neuroimag*\"[All Fields] OR (\"brain\"[MeSH Terms] OR \"brain\"[All Fields] OR \"brains\"[All Fields] OR \"brain s\"[All Fields]) OR (\"neuroglia\"[MeSH Terms] OR \"neuroglia\"[All Fields] OR \"glia\"[All Fields]) OR \"nociplastic\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_peripheral": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (small fiber OR small fibre OR peripheral OR nociceptor*) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28small+fiber+OR+small+fibre+OR+peripheral+OR+nociceptor%2A%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (((\"small\"[Journal] OR \"small\"[All Fields]) AND (\"fiber\"[All Fields] OR \"fiber s\"[All Fields] OR \"fiberized\"[All Fields] OR \"fibers\"[All Fields] OR \"fibre\"[All Fields] OR \"fibre s\"[All Fields] OR \"fibres\"[All Fields])) OR ((\"small\"[Journal] OR \"small\"[All Fields]) AND (\"fiber\"[All Fields] OR \"fiber s\"[All Fields] OR \"fiberized\"[All Fields] OR \"fibers\"[All Fields] OR \"fibre\"[All Fields] OR \"fibre s\"[All Fields] OR \"fibres\"[All Fields])) OR (\"peripheral\"[All Fields] OR \"peripherally\"[All Fields] OR \"peripherals\"[All Fields] OR \"periphereal\"[All Fields] OR \"peripheric\"[All Fields] OR \"peripherically\"[All Fields]) OR \"nociceptor*\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_immune": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (autoimmun* OR antibody OR inflammation OR cytokine*) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28autoimmun%2A+OR+antibody+OR+inflammation+OR+cytokine%2A%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (\"autoimmun*\"[All Fields] OR (\"antibodie\"[All Fields] OR \"antibodies\"[Supplementary Concept] OR \"antibodies\"[All Fields] OR \"antibodies\"[MeSH Terms] OR \"antibody s\"[All Fields] OR \"antibodys\"[All Fields] OR \"immunoglobulins\"[Supplementary Concept] OR \"immunoglobulins\"[All Fields] OR \"antibody\"[All Fields] OR \"immunoglobulins\"[MeSH Terms]) OR (\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation s\"[All Fields]) OR \"cytokine*\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_genetics_omics": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (genetic* OR GWAS OR microbiom* OR metabolom* OR omics) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28genetic%2A+OR+GWAS+OR+microbiom%2A+OR+metabolom%2A+OR+omics%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (\"genetic*\"[All Fields] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields]) OR \"microbiom*\"[All Fields] OR \"metabolom*\"[All Fields] OR (\"omics\"[Journal] OR \"omics\"[All Fields])) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_sleep_fatigue_cog": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (sleep OR fatigue OR cognition OR cognitive) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28sleep+OR+fatigue+OR+cognition+OR+cognitive%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (\"sleep\"[MeSH Terms] OR \"sleep\"[All Fields] OR \"sleeping\"[All Fields] OR \"sleeps\"[All Fields] OR \"sleep s\"[All Fields] OR (\"fatiguability\"[All Fields] OR \"fatiguable\"[All Fields] OR \"fatigue\"[MeSH Terms] OR \"fatigue\"[All Fields] OR \"fatigued\"[All Fields] OR \"fatigues\"[All Fields] OR \"fatiguing\"[All Fields] OR \"fatigueability\"[All Fields]) OR (\"cognition\"[MeSH Terms] OR \"cognition\"[All Fields] OR \"cognitions\"[All Fields] OR \"cognitive\"[All Fields] OR \"cognitively\"[All Fields] OR \"cognitives\"[All Fields]) OR (\"cognition\"[MeSH Terms] OR \"cognition\"[All Fields] OR \"cognitions\"[All Fields] OR \"cognitive\"[All Fields] OR \"cognitively\"[All Fields] OR \"cognitives\"[All Fields])) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_overlap": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (comorbid* OR overlap OR migraine OR irritable bowel OR ME/CFS) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28comorbid%2A+OR+overlap+OR+migraine+OR+irritable+bowel+OR+ME%2FCFS%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (\"comorbid*\"[All Fields] OR (\"overlap\"[All Fields] OR \"overlapped\"[All Fields] OR \"overlapping\"[All Fields] OR \"overlappings\"[All Fields] OR \"overlaps\"[All Fields]) OR (\"migrain\"[All Fields] OR \"migraine disorders\"[MeSH Terms] OR (\"migraine\"[All Fields] AND \"disorders\"[All Fields]) OR \"migraine disorders\"[All Fields] OR \"migraine\"[All Fields] OR \"migraines\"[All Fields] OR \"migraine s\"[All Fields] OR \"migraineous\"[All Fields] OR \"migrainers\"[All Fields] OR \"migrainous\"[All Fields]) OR (\"irritable bowel syndrome\"[MeSH Terms] OR (\"irritable\"[All Fields] AND \"bowel\"[All Fields] AND \"syndrome\"[All Fields]) OR \"irritable bowel syndrome\"[All Fields] OR (\"irritable\"[All Fields] AND \"bowel\"[All Fields]) OR \"irritable bowel\"[All Fields]) OR \"me cfs\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_pharm": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (drug OR pharmacolog* OR duloxetine OR pregabalin OR cyclobenzaprine OR naltrexone OR cannabinoid*) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28drug+OR+pharmacolog%2A+OR+duloxetine+OR+pregabalin+OR+cyclobenzaprine+OR+naltrexone+OR+cannabinoid%2A%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (\"drug\"[All Fields] OR \"pharmacolog*\"[All Fields] OR (\"duloxetin\"[All Fields] OR \"duloxetine hydrochloride\"[Supplementary Concept] OR \"duloxetine hydrochloride\"[All Fields] OR \"duloxetine\"[All Fields] OR \"duloxetine hydrochloride\"[MeSH Terms] OR (\"duloxetine\"[All Fields] AND \"hydrochloride\"[All Fields]) OR \"duloxetine s\"[All Fields]) OR (\"pregabalin\"[Supplementary Concept] OR \"pregabalin\"[All Fields] OR \"pregabalin\"[MeSH Terms] OR \"pregabaline\"[All Fields] OR \"pregabalin s\"[All Fields]) OR (\"cyclobenzaprine\"[Supplementary Concept] OR \"cyclobenzaprine\"[All Fields]) OR (\"naltrexone\"[Supplementary Concept] OR \"naltrexone\"[All Fields] OR \"naltrexon\"[All Fields] OR \"naltrexone\"[MeSH Terms] OR \"naltrexone s\"[All Fields]) OR \"cannabinoid*\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_nonpharm": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (exercise OR physical therapy OR cognitive behavioral OR CBT OR ACT OR acupuncture OR neuromodulation) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28exercise+OR+physical+therapy+OR+cognitive+behavioral+OR+CBT+OR+ACT+OR+acupuncture+OR+neuromodulation%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields] OR (\"physical therapy modalities\"[MeSH Terms] OR (\"physical\"[All Fields] AND \"therapy\"[All Fields] AND \"modalities\"[All Fields]) OR \"physical therapy modalities\"[All Fields] OR (\"physical\"[All Fields] AND \"therapy\"[All Fields]) OR \"physical therapy\"[All Fields]) OR ((\"cognition\"[MeSH Terms] OR \"cognition\"[All Fields] OR \"cognitions\"[All Fields] OR \"cognitive\"[All Fields] OR \"cognitively\"[All Fields] OR \"cognitives\"[All Fields]) AND (\"behavior s\"[All Fields] OR \"behaviorally\"[All Fields] OR \"behaviour\"[All Fields] OR \"behavior\"[MeSH Terms] OR \"behavior\"[All Fields] OR \"behavioural\"[All Fields] OR \"behavioral\"[All Fields] OR \"behaviourally\"[All Fields] OR \"behaviours\"[All Fields] OR \"behaviors\"[All Fields] OR \"pattern\"[All Fields] OR \"pattern s\"[All Fields] OR \"patternability\"[All Fields] OR \"patternable\"[All Fields] OR \"patterned\"[All Fields] OR \"patterning\"[All Fields] OR \"patternings\"[All Fields] OR \"patterns\"[All Fields])) OR \"CBT\"[All Fields] OR \"ACT\"[All Fields] OR (\"acupunctural\"[All Fields] OR \"acupuncture\"[MeSH Terms] OR \"acupuncture\"[All Fields] OR \"acupuncture therapy\"[MeSH Terms] OR (\"acupuncture\"[All Fields] AND \"therapy\"[All Fields]) OR \"acupuncture therapy\"[All Fields] OR \"acupuncture s\"[All Fields] OR \"acupunctured\"[All Fields] OR \"acupunctures\"[All Fields] OR \"acupuncturing\"[All Fields]) OR (\"neuromodulate\"[All Fields] OR \"neuromodulating\"[All Fields] OR \"neuromodulation\"[All Fields] OR \"neuromodulations\"[All Fields] OR \"neuromodulative\"[All Fields] OR \"neurotransmitter agents\"[Pharmacological Action] OR \"neurotransmitter agents\"[Supplementary Concept] OR \"neurotransmitter agents\"[All Fields] OR \"neuromodulator\"[All Fields] OR \"neurotransmitter agents\"[MeSH Terms] OR (\"neurotransmitter\"[All Fields] AND \"agents\"[All Fields]) OR \"neuromodulators\"[All Fields])) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_guide_safety": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (guideline OR consensus OR safety OR adverse OR opioid OR suicid*) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28guideline+OR+consensus+OR+safety+OR+adverse+OR+opioid+OR+suicid%2A%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (\"guideline\"[Publication Type] OR \"guidelines as topic\"[MeSH Terms] OR \"guideline\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]) OR (\"adverse\"[All Fields] OR \"adversely\"[All Fields] OR \"adverses\"[All Fields]) OR (\"analgesics opioid\"[Pharmacological Action] OR \"analgesics opioid\"[Supplementary Concept] OR \"analgesics opioid\"[All Fields] OR \"opioid\"[All Fields] OR \"analgesics, opioid\"[MeSH Terms] OR (\"analgesics\"[All Fields] AND \"opioid\"[All Fields]) OR \"opioid analgesics\"[All Fields] OR \"opioids\"[All Fields] OR \"opioid s\"[All Fields]) OR \"suicid*\"[All Fields]) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_outcomes_bio": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (outcome* OR FIQR OR FIQ OR biomarker* OR classifier) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28outcome%2A+OR+FIQR+OR+FIQ+OR+biomarker%2A+OR+classifier%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (\"outcome*\"[All Fields] OR \"FIQR\"[All Fields] OR \"FIQ\"[All Fields] OR \"biomarker*\"[All Fields] OR (\"classifiable\"[All Fields] OR \"classification\"[MeSH Terms] OR \"classification\"[All Fields] OR \"classified\"[All Fields] OR \"classify\"[All Fields] OR \"classifying\"[All Fields] OR \"classifier\"[All Fields] OR \"classifier s\"[All Fields] OR \"classifiers\"[All Fields] OR \"classifies\"[All Fields])) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "cochrane_patient": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (fibromyalgia OR \"chronic widespread pain\") AND (patient experience OR stigma OR qualitative OR advocacy) AND (2026/10/23:2026/10/30[dp] OR 2026/10/23:2026/10/30[edat])", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%22Cochrane+Database+Syst+Rev%22%5Bjour%5D+AND+%28fibromyalgia+OR+%22chronic+widespread+pain%22%29+AND+%28patient+experience+OR+stigma+OR+qualitative+OR+advocacy%29+AND+%282026%2F10%2F23%3A2026%2F10%2F30%5Bdp%5D+OR+2026%2F10%2F23%3A2026%2F10%2F30%5Bedat%5D%29&retmode=json&retmax=500", "count": "0", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields] OR \"chronic widespread pain\"[All Fields]) AND (((\"patient s\"[All Fields] OR \"patients\"[MeSH Terms] OR \"patients\"[All Fields] OR \"patient\"[All Fields] OR \"patients s\"[All Fields]) AND (\"experience\"[All Fields] OR \"experience s\"[All Fields] OR \"experiences\"[All Fields])) OR (\"social stigma\"[MeSH Terms] OR (\"social\"[All Fields] AND \"stigma\"[All Fields]) OR \"social stigma\"[All Fields] OR \"stigma\"[All Fields] OR \"stigmas\"[All Fields] OR \"stigma s\"[All Fields]) OR (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields]) OR (\"advocacies\"[All Fields] OR \"advocacy\"[All Fields] OR \"advocacy s\"[All Fields])) AND (2026/10/23:2026/10/30[Date - Publication] OR 2026/10/23:2026/10/30[Date - Entry])", "ids": [], "warnings": { "phrasesignored": [], "quotedphrasesnotfound": [], "outputmessages": [ "No items found." ] }, "error": null }, "magic_guideline": { "query": "fibromyalgia AND (\"rapid recommendation\" OR MAGIC OR \"clinical practice guideline\") AND 2026[dp]", "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=fibromyalgia+AND+%28%22rapid+recommendation%22+OR+MAGIC+OR+%22clinical+practice+guideline%22%29+AND+2026%5Bdp%5D&retmode=json&retmax=500", "count": "4", "translation": "(\"fibromyalgia\"[MeSH Terms] OR \"fibromyalgia\"[All Fields] OR \"fibromyalgias\"[All Fields]) AND (\"rapid recommendation\"[All Fields] OR (\"magic\"[MeSH Terms] OR \"magic\"[All Fields] OR \"magics\"[All Fields]) OR \"clinical practice guideline\"[All Fields]) AND 2026/01/01:2026/12/31[Date - Publication]", "ids": [ "42851751", "42673606", "42673560", "42262745" ], "warnings": {}, "error": null } }, "pubmed_records": [ { "pmid": "28800217", "title": "Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates.", "journal": "ACS Chem Biol", "year": "2017", "volume": "12", "pages": "2427-2435", "publication_types": [ "Journal Article" ], "ids": { "pubmed": "28800217", "doi": "10.1021/acschembio.7b00542" } }, { "pmid": "31387871", "title": "Use of Cryopreserved Hepatocytes as Part of an Integrated Strategy to Characterize In Vivo Clearance for Peptide-Antibody Conjugate Inhibitors of Nav1.7 in Preclinical Species.", "journal": "Drug Metab Dispos", "year": "2019", "volume": "47", "pages": "1111-1121", "publication_types": [ "Journal Article" ], "ids": { "pubmed": "31387871", "doi": "10.1124/dmd.119.087742", "pii": "S0090-9556(24)07810-3" } }, { "pmid": "37656420", "title": "Rozanolixizumab: First Approval.", "journal": "Drugs", "year": "2023", "volume": "83", "pages": "1341-1347", "publication_types": [ "Journal Article", "Review" ], "ids": { "pubmed": "37656420", "pmc": "PMC10590285", "doi": "10.1007/s40265-023-01933-1", "pii": "10.1007/s40265-023-01933-1" } }, { "pmid": "40612406", "title": "Fibromyalgia syndrome-am I an autoimmune condition?", "journal": "Pain Rep", "year": "2025", "volume": "10", "pages": "e1270", "publication_types": [ "Journal Article", "Review" ], "ids": { "pubmed": "40612406", "pmc": "PMC12226001", "doi": "10.1097/PR9.0000000000001270", "pii": "PAINREPORTS-D-24-0125" } }, { "pmid": "41284548", "title": "Efficacy and safety of nipocalimab in patients with moderate-to-severe Sjögren's disease (DAHLIAS): a randomised, phase 2, placebo-controlled, double-blind trial.", "journal": "Lancet", "year": "2025", "volume": "406", "pages": "2435-2448", "publication_types": [ "Journal Article", "Clinical Trial, Phase II", "Randomized Controlled Trial", "Multicenter Study", "Research Support, Non-U.S. Gov't" ], "ids": { "pubmed": "41284548", "doi": "10.1016/S0140-6736(25)01430-8", "pii": "S0140-6736(25)01430-8" } }, { "pmid": "42262745", "title": "SIMFER guidelines on physical modalities for chronic primary pain management.", "journal": "Eur J Phys Rehabil Med", "year": "2026", "volume": "62", "pages": "221-231", "publication_types": [ "Journal Article", "Practice Guideline" ], "ids": { "pubmed": "42262745", "pmc": "PMC13411331", "doi": "10.23736/S1973-9087.26.09631-0", "pii": "S1973-9087.26.09631-0" } }, { "pmid": "42633339", "title": "Bridging the Gap in Sjögren's Disease: A Comprehensive Review of Unmet Needs, Diagnostic Challenges, and Emerging Therapeutic Strategies.", "journal": "Cureus", "year": "2026", "volume": "18", "pages": "e113186", "publication_types": [ "Journal Article", "Review" ], "ids": { "pubmed": "42633339", "pmc": "PMC13499635", "doi": "10.7759/cureus.113186" } }, { "pmid": "42673560", "title": "Pharmacologic Treatment for Migraine Prevention in Adults Practice Guideline Recommendations: Report of the AAN Guidelines Subcommittee and the American Headache Society.", "journal": "Neurology", "year": "2026", "volume": "107", "pages": "e214881", "publication_types": [ "Journal Article", "Practice Guideline" ], "ids": { "pubmed": "42673560", "doi": "10.1212/WNL.0000000000214881" } }, { "pmid": "42673606", "title": "Pharmacologic Treatment for Migraine Prevention in Adults Practice Guideline Recommendations: Report of the AAN Guidelines Subcommittee and the American Headache Society.", "journal": "Headache", "year": "2026", "volume": "66", "pages": "2173-2184", "publication_types": [ "Journal Article", "Practice Guideline" ], "ids": { "pubmed": "42673606", "doi": "10.1111/head.70199" } }, { "pmid": "42748952", "title": "Efficacy and safety of rozanolixizumab in severe fibromyalgia: a phase 2A randomised, double-blind, placebo-controlled, multicentre trial.", "journal": "Lancet Rheumatol", "year": "2026", "volume": "8", "pages": "e864-e875", "publication_types": [ "Journal Article", "Randomized Controlled Trial", "Multicenter Study", "Clinical Trial, Phase II" ], "ids": { "pubmed": "42748952", "doi": "10.1016/S2665-9913(26)00252-3", "pii": "S2665-9913(26)00252-3" } }, { "pmid": "42821997", "title": "Concomitant Fibromyalgia in Patients With Other Rheumatic Diseases: Pain Level and Treatment Response.", "journal": "J Clin Rheumatol", "year": "2026", "volume": "", "pages": "", "publication_types": [ "Journal Article" ], "ids": { "pubmed": "42821997", "doi": "10.1097/RHU.0000000000002404", "pii": "00124743-990000000-00504" } }, { "pmid": "42851751", "title": "Drug treatments for fibromyalgia: systematic review and network meta-analysis of randomised trials.", "journal": "BMJ Med", "year": "2026", "volume": "5", "pages": "e002902", "publication_types": [ "Journal Article", "Network Meta-Analysis", "Systematic Review" ], "ids": { "pubmed": "42851751", "pmc": "PMC13647175", "doi": "10.1136/bmjmed-2026-002902", "pii": "bmjmed-2026-002902" } }, { "pmid": "42910234", "title": "FiRST Screening Positivity Among Patients Attending a Tertiary Chronic Pain service in Oman.", "journal": "J Pain Res", "year": "2026", "volume": "19", "pages": "652210", "publication_types": [ "Journal Article" ], "ids": { "pubmed": "42910234", "pmc": "PMC13685692", "doi": "10.2147/JPR.S652210", "pii": "652210" } }, { "pmid": "42912713", "title": "Feeling the Body in Fibromyalgia: A Narrative Review of Interoception and Proprioception within a Phenomenological Perspective.", "journal": "Psychopathology", "year": "2026", "volume": "", "pages": "1", "publication_types": [ "Journal Article", "Review" ], "ids": { "pubmed": "42912713", "doi": "10.1159/psp/aelag015", "pii": "000555032" } }, { "pmid": "42914549", "title": "Cost-effectiveness of adjunctive hyperbaric oxygen therapy for fibromyalgia: an economic evaluation alongside a single-centre randomised controlled trial in Brazil.", "journal": "BMJ Open", "year": "2026", "volume": "16", "pages": "e115739", "publication_types": [ "Journal Article" ], "ids": { "pubmed": "42914549", "pmc": "PMC13691853", "doi": "10.1136/bmjopen-2025-115739", "pii": "bmjopen-2025-115739" } }, { "pmid": "42921698", "title": "Recognizing fibromyalgia-like pain phenotypes in lipedema: A narrative review.", "journal": "Phlebology", "year": "2026", "volume": "", "pages": "2683555261499760", "publication_types": [ "Journal Article", "Review" ], "ids": { "pubmed": "42921698", "doi": "10.1177/02683555261499760" } }, { "pmid": "42921774", "title": "Multi-Target Mechanism of Corydalis yanhusuo Against Fibromyalgia Syndrome: A Network Pharmacology and Molecular Docking Study.", "journal": "J Vis Exp", "year": "2026", "volume": "", "pages": "", "publication_types": [ "Journal Article", "Video-Audio Media" ], "ids": { "pubmed": "42921774", "doi": "10.3791/74233" } }, { "pmid": "42924382", "title": "Fibromyalgia in pregnancy and postpartum period: effects on quality of life, obstetric outcomes, delivery decisions, and breastfeeding: a systematic review.", "journal": "Rev Bras Ginecol Obstet", "year": "2026", "volume": "48", "pages": "", "publication_types": [ "Journal Article", "Systematic Review", "Review" ], "ids": { "pubmed": "42924382", "pmc": "PMC13690381", "doi": "10.61622/rbgo/2026rbgo49", "pii": "e-rbgo49" } }, { "pmid": "42925908", "title": "Reduction in Fear of Movement Predicts Long-Term Decreases In Functional Disability Among Adolescents With Juvenile Fibromyalgia.", "journal": "J Pain", "year": "2026", "volume": "", "pages": "106475", "publication_types": [ "Journal Article" ], "ids": { "pubmed": "42925908", "doi": "10.1016/j.jpain.2026.106475", "pii": "S1526-5900(26)00293-2" } }, { "pmid": "42926172", "title": "State-dependent roles of inflammation across pain conditions: insights from human 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"has_results": false, "error": null }, "NCT07525063": { "url": "https://clinicaltrials.gov/api/v2/studies/NCT07525063", "title": "Pain & Reward Neuromodulation of CNS Circuits", "status": "ENROLLING_BY_INVITATION", "last_update": { "date": "2026-07-28", "type": "ACTUAL" }, "results_first_posted": null, "has_results": false, "error": null }, "NCT07585045": { "url": "https://clinicaltrials.gov/api/v2/studies/NCT07585045", "title": "Effectiveness of Oral Magnesium Supplementation in Fibromyalgia Patients Not Responding to Standard Treatment", "status": "RECRUITING", "last_update": { "date": "2026-05-13", "type": "ACTUAL" }, "results_first_posted": null, "has_results": false, "error": null }, "NCT07637162": { "url": "https://clinicaltrials.gov/api/v2/studies/NCT07637162", "title": "Open-Label Safety Study of AXS-14 in Subjects With Fibromyalgia", "status": "ENROLLING_BY_INVITATION", "last_update": { "date": "2026-10-13", "type": "ACTUAL" }, "results_first_posted": null, "has_results": false, "error": null }, "NCT07753018": { "url": "https://clinicaltrials.gov/api/v2/studies/NCT07753018", "title": "Effects of Curcumin-Piperine Supplementation in Fibromyalgia", "status": "NOT_YET_RECRUITING", "last_update": { "date": "2026-08-11", "type": "ACTUAL" }, "results_first_posted": null, "has_results": false, "error": null }, "NCT07783295": { "url": "https://clinicaltrials.gov/api/v2/studies/NCT07783295", "title": "Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in Women", "status": "NOT_YET_RECRUITING", "last_update": { "date": "2026-08-26", "type": "ACTUAL" }, "results_first_posted": null, "has_results": false, "error": null } }, "comparison_with_2026_10_23_manifest": { "comparable_records": 75, "changed_records": [], "additional_baseline_id": "NCT07637162", "records_with_update_in_window": [] }, "updated_condition_query": { "url": "https://clinicaltrials.gov/api/v2/studies?query.cond=fibromyalgia&filter.advanced=AREA%5BLastUpdatePostDate%5DRANGE%5B2026-10-23%2C2026-10-30%5D&pageSize=1000&format=json&countTotal=true", "condition": "fibromyalgia", "advanced_filter": "AREA[LastUpdatePostDate]RANGE[2026-10-23,2026-10-30]", "count": 11, "next_page_token": null, "records": [ { "id": "NCT06508385", "title": "The Effect of Perception of Improvement in Patients With Fibromyalgia", "status": { "statusVerifiedDate": "2026-10", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2024-08-13", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2026-08-03", "type": "ACTUAL" }, "completionDateStruct": { "date": "2026-08-03", "type": "ACTUAL" }, "studyFirstSubmitDate": "2024-07-12", "studyFirstSubmitQcDate": "2024-07-12", "studyFirstPostDateStruct": { "date": "2024-07-18", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-10-26", "lastUpdatePostDateStruct": { "date": "2026-10-27", "type": "ACTUAL" } }, "design": { "studyType": "INTERVENTIONAL", "phases": [ "NA" ], "designInfo": { "allocation": "RANDOMIZED", "interventionModel": "PARALLEL", "primaryPurpose": "TREATMENT", "maskingInfo": { "masking": "DOUBLE", "maskingDescription": "Double", "whoMasked": [ "PARTICIPANT", "OUTCOMES_ASSESSOR" ] } }, "enrollmentInfo": { "count": 36, "type": "ACTUAL" } }, "summary": { "briefSummary": "Fibromyalgia (FM) is a chronic pain syndrome characterized by impaired perception, transmission, and processing of nociceptive stimuli and causing widespread pain. Pain in FM is the disease itself and is characterized by nociplastic pain that may occur independently of any peripheral nociceptor activity or be felt without disease or damage to the somatosensory system. It is thought that the pain processing process is disrupted due to the changing neurotransmitter release activity and this situation causes pain to be felt more in FM. Chronic pain is the result of perception alteration associated with nociceptive afferent information affecting the cortex; underlying this change are limbic emotional learning mechanisms. Numerous factors, including emotional state, attention, and past painful experiences, modulate nociceptive inputs with the activation of multiple brain regions, resulting in a personalized pain experience. The chronic pain management program should target the central nervous system rather than the peripheral tissues because pain originates in the sensitized nervous system. For this reason, it is important to include plasticity-oriented approaches, cortical disinhibition methods, and strategies for improving perception and behavior change, which aim to replace negative beliefs with positive beliefs, into clinical practice. Our project aims to investigate the effectiveness of the therapeutic intervention, which consists of patient education supported Neuro-Linguistic Programming (NLP), visual feedback and metaphor-assisted breathing therapy designed to provide a perception of improvement and presented in a virtual reality environment, on pain processing, pain intensity, pain-pressure threshold, psychosomatic reflections (biomechanical and viscoelastic properties of tissue, sleep quality, pain catastrophizing behavior, anxiety and depression), disease impact and quality of life in FM patients." }, "outcomes": { "primaryOutcomes": [ { "measure": "Functional Magnetic Resonance", "description": "The process of processing pain will be determined by functional magnetic resonance imaging performed immediately before and after the experimental pressure pain. ROI analysis will ve performed. No score is defined.", "timeFrame": "Measurement of changes from baseline process of processing pain will be measured at 6 week and 10 week" }, { "measure": "Measurement of pain-pressure threshold", "description": "Pain-pressure threshold evaluated with a pain threshold measuring device (Algometer).", "timeFrame": "Measurement of changes from baseline of pain-pressure threshold will be measured at 6 week and 10 week" } ], "secondaryOutcomes": [ { "measure": "Sleep Quality", "description": "Sleep quality will be evaluated with Pittsburgh Sleep Quality Index. Score is between 0 (the best sleep quality) and 21 (the worst sleep quality)", "timeFrame": "Measurement of changes from baseline of sleep quality will be measured at 6 week and 10 week" }, { "measure": "Functional status and disease impact", "description": "Functional status and disease impact will be evaluated with Revised Fibromyalgia Impact Questionnaire. Score is between 0 (no disease impact and 100 (the highest disease impact)", "timeFrame": "Measurement of changes from baseline of functional status and disease impact will be measured at 6 week and 10 week." }, { "measure": "Quality of Life of patients", "description": "Quality of Life will be measured with QOL Short Form 12. Score is between 0 (the lowest quality of life and 100 (the highest quality of life)", "timeFrame": "Measurement of changes from baseline of quality of life will be measured at 6 week and 10 week" }, { "measure": "Anxiety and Depression Status", "description": "Anxiety and Depression will be evaluated with Hospital Anxiety and Depression Scale. Score is between 0 (no anxiety and depression risk) and 21 (the highest anxiety and depression risk)", "timeFrame": "Measurement of changes from baseline of anxiety and depression status will be measured at 6 week and 10 week" }, { "measure": "Pain catastrophizing behavior", "description": "Assessing pain catastrophizing behavior will be evaluated with Pain Catastrophizing Scale. Score is between 0 (no pain catastrophizing behavior) and 52 (the highest pain catastrophizing behavior)", "timeFrame": "Measurement of changes from baseline of changes from baseline of pain catastrophizing behaviors will be measured at 6 week and 10 week" }, { "measure": "Patient satisfaction", "description": "Patient satisfaction will be evaluated with Global Rating of Change. No score is defined.", "timeFrame": "Measurement of changes from baseline of patient satisfaction will be measured at 6 week and 10 week" }, { "measure": "Measurement of biomechanical characteristics of tissue", "description": "Stiffness values of tissue will be measured with myotonPro B1 over the three most painful points in Control Group and Virtual Reality-1 Group.\n\nStiffness values of tissue will be measured with myotonPro B1 over the contralateral of the points reported as the three most painful points in Virtual Reality-2 Group.", "timeFrame": "Measurement of changes from baseline stiffness values of tissue will be measured at 6 week and 10 week]" }, { "measure": "Measurement of biomechanical characteristics of tissue", "description": "Tone values of tissue will be measured with myotonPro B1 over the three most painful points in Control Group and Virtual Reality-1 Group.\n\nTone values of tissue will be measured with myotonPro B1 over the contralateral of the points reported as the three most painful points in Virtual Reality-2 Group.", "timeFrame": "Measurement of changes from baseline tone values of tissue will be measured at 6 week and 10 week]" }, { "measure": "Measurement of biomechanical characteristics of tissue", "description": "Decrement values of tissue will be measured with myotonPro B1 over the three most painful points in Control Group and Virtual Reality-1 Group.\n\nDecrement values of tissue will be measured with myotonPro B1 over the contralateral of the points reported as the three most painful points in Virtual Reality-2 Group.", "timeFrame": "Measurement of changes from baseline decrement values of tissue will be measured at 6 week and 10 week]" }, { "measure": "Measurement of viscoelastic characteristics of tissue", "description": "Creep values of tissue will be measured with myotonPro B1 over the three most painful points in Control Group and Virtual Reality-1 Group.\n\nCreep values of tissue will be measured with myotonPro B1 over the contralateral of the points reported as the three most painful points in Virtual Reality-2 Group.", "timeFrame": "Measurement of changes from baseline creep values of tissue will be measured at 6 week and 10 week]" }, { "measure": "Measurement of viscoelastic characteristics of tissue", "description": "Relaxation time values of tissue will be measured with myotonPro B1 over the three most painful points in Control Group and Virtual Reality-1 Group.\n\nRelaxation time values of tissue will be measured with myotonPro B1 over the contralateral of the points reported as the three most painful points in Virtual Reality-2 Group.", "timeFrame": "Measurement of changes from baseline relaxation time values of tissue will be measured at 6 week and 10 week]" } ] }, "eligibility": { "eligibilityCriteria": "Inclusion Criteria:\n\nDiagnosed with Fibromyalgia at least 1 year ago according to ACR criteria\n\nAge range 25-55\n\nFemale\n\nScored at least 24 on the Mini-Mental State Assessment Test\n\nReported weekly pain intensity of at least 40 mm on the Visual Analog Scale\n\nBe on a stable dose of medication for at least 6 months (serotonin norepinephrine reuptake inhibitors \\[e.g., duloxetine, milnacipran\\]; alpha 2-delta receptor ligand \\[e.g., pregabalin\\]; gabapentinoids)\n\nExclusion Criteria:\n\nHaving inflammatory rheumatic disease, malignancy, neurological disease, connective tissue disease, severe anemia, uncontrolled endocrine diseases\n\nBody Mass Index (BMI) ≥ 30 Kg/m2\n\nBeing pregnant\n\nHaving inability to understand, read and speak Turkish\n\nHaving difficulty in hearing and seeing\n\nHaving any metallic or electronic device in the body that will create incompatibility with the magnetic field in the fMRI scan Having any disease diagnosis (serious psychotic disorder, delirium, mental retardation, epilepsy, heart disease, lung diseases, etc.) that may prevent participation in the evaluation and training to be conducted within the scope of the research", "healthyVolunteers": false, "sex": "FEMALE", "genderBased": true, "genderDescription": "Fibromyalgia patient", "minimumAge": "25 Years", "maximumAge": "55 Years", "stdAges": [ "ADULT" ] }, "countries": [ "Turkey (Türkiye)" ], "has_results": false }, { "id": "NCT05329571", "title": "The Effects of Dietary Changes on Gut-bacteria and Fibromyalgia Symptoms", "status": { "statusVerifiedDate": "2026-10", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2021-03-12", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2022-06-15", "type": "ACTUAL" }, "completionDateStruct": { "date": "2022-07-06", "type": "ACTUAL" }, "studyFirstSubmitDate": "2022-02-22", "studyFirstSubmitQcDate": "2022-04-07", "studyFirstPostDateStruct": { "date": "2022-04-15", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-10-22", "lastUpdatePostDateStruct": { "date": "2026-10-26", "type": "ACTUAL" } }, "design": { "studyType": "INTERVENTIONAL", "phases": [ "NA" ], "designInfo": { "allocation": "RANDOMIZED", "interventionModel": "PARALLEL", "primaryPurpose": "TREATMENT", "maskingInfo": { "masking": "NONE" } }, "enrollmentInfo": { "count": 59, "type": "ACTUAL" } }, "summary": { "briefSummary": "The purpose of this study is to evaluate the efficacy of two diets - gluten-free and low-FODMAP diet- in relieving symptoms of fibromyalgia, and study whether these changes could be associated with changes in the gut microbiome (gut bacteria)." }, "outcomes": { "primaryOutcomes": [ { "measure": "Changes in gut microbiome composition in response to dietary intervention", "description": "Genome structure, structural variants - Differential abundance analysis will be performed using 16S rRNA.", "timeFrame": "Four weeks after the initiation of the new diet compared to baseline." }, { "measure": "Changes in stool microbiota-related metabolites affecting host physiology, in response to dietary intervention.", "description": "Metabolomics analysis will be performed (Metabolon, USA) - targeted metabolomic for bile acids and SCFA analysis.", "timeFrame": "Four weeks after the initiation of the new diet compared to baseline." }, { "measure": "Changes in blood microbiota-related metabolites, affecting host physiology, in response to dietary intervention", "description": "Metabolomics analysis will be performed (Metabolon, USA) - targeted metabolomic for bile acids and SCFA analysis.", "timeFrame": "Four weeks after the initiation of the new diet compared to baseline." } ], "secondaryOutcomes": [ { "measure": "The Fibromyalgia Survey Diagnostic Criteria and Severity Scale (FSDC) scores.", "description": "assessing symptom severity, pain distribution, fatigue, sleep quality and cognitive and somatic complaints in fibromyalgia patients.\n\nA questionnaire assessing symptom severity, pain distribution, fatigue, sleep quality and cognitive and somatic complaints in fibromyalgia patients.", "timeFrame": "Four weeks after the initiation of the new diet compared to baseline." }, { "measure": "The Fibromyalgia Impact Questionnaire (FIQ) score", "description": "A 10 items questionnaire evaluating physical functioning, work difficulty, pain, fatigue, morning tiredness, stiffness, anxiety and depression.", "timeFrame": "Four weeks after the initiation of the new diet compared to baseline." }, { "measure": "Hospital Anxiety and Depression Scale (HADS) score", "description": "A 14-items questionnaire assessing the level of depression and anxiety.", "timeFrame": "Four weeks after the initiation of the new diet compared to baseline." }, { "measure": "The Pittsburg Sleep Quality Index scores", "description": "An 11 item sleep quality evaluation questionnaire.", "timeFrame": "Four weeks after the initiation of the new diet compared to baseline." }, { "measure": "ROME IV criteria for irritable bowel syndrome", "description": "Four yes-or-no items", "timeFrame": "Four weeks after the initiation of the new diet compared to baseline." } ] }, "eligibility": { "eligibilityCriteria": "Inclusion Criteria:\n\n1. Women over the age of 18, diagnosed with FM.\n2. Chronic widespread pain index \\>= 9 and pain intensity \\>= 6.\n3. Able to read and write in either French or English.\n\nExclusion Criteria:\n\n1. Any major illness (e.g. malignancy, active inflammatory disease, metabolic disease, etc.)\n2. Inflammatory bowel disease.\n3. Severe depression (HADS score for depression \\> 10).\n4. Current use of LFD or GFD.\n5. Pregnancy\n6. Vegan diet\n\nThe inclusion/exclusion criteria were set to reduce the risk of confounding factors that could affect gut microbiota composition. To date, information on microbiome alterations in individuals with fibromyalgia is only available for female patients, and thus recruitment will be limited to women.", "healthyVolunteers": false, "sex": "FEMALE", "minimumAge": "18 Years", "stdAges": [ "ADULT", "OLDER_ADULT" ] }, "countries": [ "Canada" ], "has_results": false }, { "id": "NCT07904468", "title": "Daily Cognitive Failures and Medication Adherence in Fibromyalgia", "status": { "statusVerifiedDate": "2026-10", "overallStatus": "NOT_YET_RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2026-12-15", "type": "ESTIMATED" }, "primaryCompletionDateStruct": { "date": "2027-11-15", "type": "ESTIMATED" }, "completionDateStruct": { "date": "2027-12-15", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2026-10-12", "studyFirstSubmitQcDate": "2026-10-23", "studyFirstPostDateStruct": { "date": "2026-10-29", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-10-23", "lastUpdatePostDateStruct": { "date": "2026-10-29", "type": "ACTUAL" } }, "design": { "studyType": "OBSERVATIONAL", "patientRegistry": false, "designInfo": { "observationalModel": "CASE_CONTROL", "timePerspective": "CROSS_SECTIONAL" }, "enrollmentInfo": { "count": 70, "type": "ESTIMATED" } }, "summary": { "briefSummary": "This study aims to investigate the relationship between everyday cognitive failures and medication adherence in adults with fibromyalgia.\n\nFibromyalgia is a chronic condition associated with widespread pain, fatigue, and cognitive difficulties such as forgetfulness and problems with attention. These difficulties may affect patients' ability to take prescribed medications regularly, but their relationship with medication adherence remains unclear.\n\nThis single-center, observational, cross-sectional study will include 70 adults aged 18-65 years diagnosed with fibromyalgia who regularly take at least one medication for the condition.\n\nEveryday cognitive failures will be assessed using the Cognitive Failures Questionnaire (CFQ), and medication adherence will be assessed using the five-item Medication Adherence Report Scale (MARS-5). Anxiety and depressive symptoms will be evaluated using the Hospital Anxiety and Depression Scale (HADS). Information on pain severity, medications, and daily medication-taking frequency will also be collected.\n\nThe study will examine whether greater cognitive failures are associated with lower medication adherence and whether this relationship remains after accounting for anxiety, depressive symptoms, number of regularly used medications, and daily medication-taking frequency.\n\nAll assessments will be completed during a single visit lasting approximately 12-15 minutes. No experimental treatments, additional laboratory tests, or invasive procedures will be performed.", "detailedDescription": "Cognitive difficulties are frequently reported by individuals with fibromyalgia and may involve attention, memory, and everyday cognitive functioning. Although cognitive impairment and medication adherence have been investigated separately in fibromyalgia, the relationship between everyday cognitive failures and adherence to prescribed medication remains insufficiently understood.\n\nThe primary objective of this study is to evaluate the association between everyday cognitive failures, measured by the Cognitive Failures Questionnaire (CFQ), and medication adherence, measured by the five-item Medication Adherence Report Scale (MARS-5).\n\nThe MARS-5 total score will serve as the primary outcome variable, while the CFQ total score will be the main explanatory variable. Higher MARS-5 scores indicate better medication adherence, whereas higher CFQ scores indicate more frequent everyday cognitive failures. For participants using multiple medications for fibromyalgia, adherence will be assessed for the medication used regularly for the longest duration.\n\nThe relationship between CFQ and MARS-5 total scores will be examined using Pearson or Spearman correlation analysis, depending on the distribution of the data.\n\nA multivariable linear regression model will additionally be used to assess whether cognitive failures are independently associated with medication adherence after adjustment for anxiety symptoms, depressive symptoms, the number of regularly used medications, and daily medication-taking frequency.\n\nExploratory analyses will investigate the associations of age, sex, educational level, duration of fibromyalgia, and pain severity with CFQ and MARS-5 scores.\n\nThe study will be conducted at the Physical Medicine and Rehabilitation Outpatient Clinic of Mardin Training and Research Hospital, Türkiye. Participants will complete all assessments during a single visit without any additional medical intervention.\n\nAs this is a cross-sectional study, the findings will be interpreted as associations and will not establish causal relationships." }, "outcomes": { "primaryOutcomes": [ { "measure": "Medication Adherence Assessed by MARS-5 in Relation to Pain Severity", "description": "Medication adherence will be measured using the five-item Medication Adherence Report Scale (MARS-5). Total scores range from 5 to 25, with higher scores indicating better medication adherence. The association between MARS-5 total scores and pain severity, assessed using the Numeric Rating Scale (NRS; 0-10), will be examined as an exploratory analysis. MARS-5 will be the outcome variable, and pain severity will be the explanatory variable.", "timeFrame": "Baseline" } ], "secondaryOutcomes": [ { "measure": "Everyday Cognitive Failures Assessed by the Cognitive Failures Questionnaire (CFQ)", "description": "Everyday cognitive failures will be assessed using the 25-item Cognitive Failures Questionnaire (CFQ). Each item is scored from 0 to 3, yielding a total score ranging from 0 to 75. Higher scores indicate more frequent everyday cognitive failures, whereas lower scores indicate fewer cognitive failures.", "timeFrame": "Baseline" }, { "measure": "Anxiety Symptoms Assessed by the Hospital Anxiety and Depression Scale (HADS-A)", "description": "Anxiety symptoms will be assessed using the seven-item anxiety subscale of the Hospital Anxiety and Depression Scale (HADS-A). Each item is scored from 0 to 3, yielding a total score ranging from 0 to 21. Higher scores indicate more severe anxiety symptoms, whereas lower scores indicate fewer anxiety symptoms.", "timeFrame": "Baseline" } ], "otherOutcomes": [ { "measure": "Pain Severity Assessed by the Numeric Rating Scale (NRS)", "description": "Average fibromyalgia pain severity during the preceding week will be assessed using the Numeric Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain). Higher scores indicate greater pain severity, whereas lower scores indicate less pain.", "timeFrame": "Baseline" } ] }, "eligibility": { "eligibilityCriteria": "Inclusion Criteria:\n\n* Adults aged 18-65 years.\n* Diagnosis of fibromyalgia according to the 2016 American College of Rheumatology (ACR) criteria.\n* Regular use of at least one medication for fibromyalgia.\n* Willingness to participate in the study and provision of written informed consent.\n\nExclusion Criteria:\n\n* Cognitive impairment severe enough to prevent reliable completion of the assessment questionnaires.\n* Active psychotic disorder or severe psychiatric illness that significantly interferes with participation in the assessment.\n* Pregnancy, postpartum period, or breastfeeding.\n* Communication difficulties that prevent understanding or answering the study questionnaires.", "healthyVolunteers": false, "sex": "ALL", "minimumAge": "18 Years", "maximumAge": "65 Years", "stdAges": [ "ADULT", "OLDER_ADULT" ], "studyPopulation": "The study population will consist of 70 adults aged 18-65 years diagnosed with fibromyalgia according to the 2016 ACR criteria and regularly taking at least one medication for fibromyalgia. Participants will be recruited from the Physical Medicine and Rehabilitation Outpatient Clinic of Mardin Training and Research Hospital, Türkiye. Eligible patients who provide written informed consent will undergo a single-visit assessment of everyday cognitive failures, medication adherence, anxiety and depressive symptoms, pain severity, and medication use.", "samplingMethod": "NON_PROBABILITY_SAMPLE" }, "countries": [ "Turkey (Türkiye)" ], "has_results": false }, { "id": "NCT02979574", "title": "PEACE: Comparing Chronic Pain Treatment Options", "status": { "statusVerifiedDate": "2026-10", "overallStatus": "ACTIVE_NOT_RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2016-11", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2026-11", "type": "ESTIMATED" }, "completionDateStruct": { "date": "2026-11", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2016-11-28", "studyFirstSubmitQcDate": "2016-11-30", "studyFirstPostDateStruct": { "date": "2016-12-01", "type": "ESTIMATED" }, "lastUpdateSubmitDate": "2026-10-22", "lastUpdatePostDateStruct": { "date": "2026-10-26", "type": "ACTUAL" } }, "design": { "studyType": "INTERVENTIONAL", "phases": [ "NA" ], "designInfo": { "allocation": "RANDOMIZED", "interventionModel": "PARALLEL", "primaryPurpose": "TREATMENT", "maskingInfo": { "masking": "SINGLE", "whoMasked": [ "OUTCOMES_ASSESSOR" ] } }, "enrollmentInfo": { "count": 360, "type": "ACTUAL" } }, "summary": { "briefSummary": "The purpose of this study is to compare two types of acupuncture with usual care on treating chronic pain. This study has three groups. Two groups will received acupuncture. One group will receive usual standard of care for 12 weeks and then will receive acupuncture. Acupuncture is an ancient Chinese technique of using very thin needles inserted in the skin to treat different symptoms and illness, and to promote healing. Each group will undergo a different method of needle administration." }, "outcomes": { "primaryOutcomes": [ { "measure": "Pain intensity and pain interference will be measured by using the Brief Pain Inventory (BPI) measure.", "timeFrame": "12 weeks" } ] }, "eligibility": { "eligibilityCriteria": "Inclusion Criteria:\n\n* English speaking\n* Age \\>/= 18 years or older\n* Having musculoskeletal pain, defined as regional (joints, extremities, back, neck) or more generalized (fibromyalgia or chronic widespread pain)\n* Having a pain rating of 4 or greater in worst pain on a 1-10 numerical rating scale in the preceding week (Patients with a neuropathic component to their pain that involves the extremities or back will be eligible)\n* Having had pain for at least 3 months and at least 15 days with pain in the preceding 30 days\n* A diagnosis of cancer with no restrictions placed on type of cancer, other than that patients with metastatic disease will be excluded. Eligibility criteria are not restricted to MSK confirmed biopsy/diagnosis. Participating institution's testing is sufficient for other study sites.\n* Complete active treatment (surgery, chemotherapy, and/or radiotherapy) at least one month prior to study initiation (patients on continued hormone treatment will not be excluded).\n\nExclusion Criteria:\n\n* Have non-musculoskeletal pain syndromes (headache, facial pain, chest pain, visceral abdominal pain) if these are the sole source of pain, but can be present as co-morbid conditions as long as a patient has a primary musculoskeletal pain condition defined s above.\n* Inflammatory arthritis that require disease modifying drugs (e.g. rheumatoid arthritis)\n* Phantom limb pain\n* Patients with a history of metastatic cancer who are not currently NED\n* Have a pending pain-related VA or social security or worker's comp disability claim by self-report\n* Have an implanted electronically charged medical device", "healthyVolunteers": true, "sex": "ALL", "minimumAge": "18 Years", "stdAges": [ "ADULT", "OLDER_ADULT" ] }, "countries": [ "United States" ], "has_results": false }, { "id": "NCT07904364", "title": "Agreement Between CSI and IASP Pain Classification in Chronic Cervical Myofascial Pain", "status": { "statusVerifiedDate": "2026-10", "overallStatus": "NOT_YET_RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2026-12-10", "type": "ESTIMATED" }, "primaryCompletionDateStruct": { "date": "2027-06-15", "type": "ESTIMATED" }, "completionDateStruct": { "date": "2027-06-15", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2026-10-22", "studyFirstSubmitQcDate": "2026-10-23", "studyFirstPostDateStruct": { "date": "2026-10-29", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-10-23", "lastUpdatePostDateStruct": { "date": "2026-10-29", "type": "ACTUAL" } }, "design": { "studyType": "OBSERVATIONAL", "patientRegistry": false, "designInfo": { "observationalModel": "CASE_ONLY", "timePerspective": "CROSS_SECTIONAL" }, "enrollmentInfo": { "count": 150, "type": "ESTIMATED" } }, "summary": { "briefSummary": "This study aims to investigate how closely two approaches to assessing pain-related characteristics agree in adults with chronic cervical myofascial pain syndrome (chronic neck pain associated with painful muscle trigger points).\n\nThe Central Sensitization Inventory (CSI) is a questionnaire that assesses symptoms associated with increased pain sensitivity. The International Association for the Study of Pain (IASP) has developed clinical criteria to identify nociplastic pain, a type of pain that cannot be fully explained by tissue damage or nerve injury. These approaches provide different types of information, and it is unclear how often they classify patients with chronic cervical myofascial pain in the same way.\n\nThis observational, cross-sectional study will include 150 adults aged 18 years or older with chronic cervical myofascial pain syndrome.\n\nParticipants will undergo a clinical assessment based on the IASP nociplastic pain criteria and complete the CSI, Neck Disability Index (NDI), and Revised Illness Perception Questionnaire (IPQ-R). Pain severity and relevant clinical information will also be recorded.\n\nThe main objective is to determine the agreement between CSI classification using a cutoff score of 40 and IASP clinical classification of nociplastic pain.\n\nThe study will also examine how often the two approaches produce different classifications and whether patients with matching or differing classifications report different emotional responses to their illness.\n\nAll assessments will be completed during a single visit. No experimental treatments or additional invasive procedures will be performed.", "detailedDescription": "Chronic cervical myofascial pain syndrome is characterized by persistent neck pain and tenderness associated with active myofascial trigger points. Although myofascial pain is primarily considered nociceptive, some patients may also exhibit nociplastic pain characteristics that are not fully explained by local muscle findings.\n\nThe International Association for the Study of Pain (IASP) has proposed clinical criteria for nociplastic pain affecting the musculoskeletal system. These criteria consider pain duration and distribution, whether pain can be fully explained by nociceptive or neuropathic mechanisms, clinically evoked pain hypersensitivity, and associated symptoms.\n\nThe Central Sensitization Inventory (CSI) is a patient-reported questionnaire assessing symptoms associated with central sensitivity syndromes. A cutoff score of 40 is commonly used to distinguish patients with higher symptom burden. However, CSI classification does not necessarily correspond to clinical nociplastic pain classification.\n\nThe primary objective of this study is to assess the agreement between CSI classification (scores below 40 versus 40 or higher) and IASP clinical classification (not meeting the criteria versus meeting the criteria for at least possible nociplastic pain) in adults with chronic cervical myofascial pain syndrome.\n\nAgreement will be quantified using Cohen's kappa coefficient with a 95% confidence interval. The original IASP categories (not meeting the criteria, possible nociplastic pain, and probable nociplastic pain) will be retained in the study records.\n\nSecondary objectives include determining the overall frequency of disagreement and identifying both directions of discordance: patients with CSI scores of 40 or higher who do not meet IASP criteria, and patients with CSI scores below 40 who meet the criteria for at least possible nociplastic pain.\n\nThe study will also investigate whether illness perception differs among the four groups formed by the combination of CSI and IASP classifications. The primary focus of this secondary analysis will be the emotional representations dimension of the Revised Illness Perception Questionnaire (IPQ-R). Differences will be evaluated while accounting for pain severity measured by the Numeric Rating Scale (NRS) and neck-related disability measured by the Neck Disability Index (NDI).\n\nOther IPQ-R dimensions will be examined in exploratory analyses. An additional agreement analysis will be conducted using only the probable nociplastic pain category as the positive IASP classification.\n\nClinical assessment will be performed before administration of the patient-reported questionnaires. The clinician performing the IASP assessment will not have access to the CSI or IPQ-R results when determining the clinical classification.\n\nThe study will be conducted at the Physical Medicine and Rehabilitation Outpatient Clinic of Mardin Training and Research Hospital, Türkiye. All information will be collected during a single assessment visit.\n\nThe findings may help clarify how patient-reported symptoms and clinical nociplastic pain criteria relate to one another and whether" }, "outcomes": { "primaryOutcomes": [ { "measure": "Agreement Between CSI and IASP Nociplastic Pain Classifications", "description": "Agreement between the Central Sensitization Inventory (CSI) and the International Association for the Study of Pain (IASP) clinical nociplastic pain classification will be quantified using Cohen's kappa coefficient with a 95% confidence interval. CSI scores will be categorized as below 40 or 40 and above. IASP classifications will be dichotomized as not meeting the criteria or meeting the criteria for at least possible nociplastic pain (possible or probable). Cohen's kappa ranges from -1 to 1, with 1 indicating perfect agreement, 0 indicating agreement expected by chance, and negative values indicating less agreement than expected by chance.", "timeFrame": "baseline" } ], "secondaryOutcomes": [ { "measure": "Overall Discordance Rate Between CSI and IASP Classifications", "description": "The percentage of participants with discordant CSI and IASP classifications will be calculated. Discordance is defined as either a CSI score of 40 or higher without meeting the IASP criteria for nociplastic pain, or a CSI score below 40 while meeting the IASP criteria for at least possible nociplastic pain. The overall discordance rate will be reported as a percentage with a 95% confidence interval calculated using the Wilson method.", "timeFrame": "baseline" }, { "measure": "Discordance Rate for CSI-Positive and IASP-Negative Classification", "description": "The percentage of all evaluated participants with a CSI score of 40 or higher who do not meet the IASP clinical criteria for nociplastic pain will be calculated. This represents one direction of disagreement between the two classification approaches. The proportion will be reported with a 95% confidence interval using the Wilson method.", "timeFrame": "baseline" }, { "measure": "Discordance Rate for CSI-Negative and IASP-Positive Classification", "description": "The percentage of all evaluated participants with a CSI score below 40 who meet the IASP criteria for at least possible nociplastic pain will be calculated. The IASP-positive category includes possible and probable nociplastic pain. This represents the opposite direction of disagreement between the two classification approaches. The proportion will be reported with a 95% confidence interval using the Wilson method.", "timeFrame": "baseline" }, { "measure": "Differences in IPQ-R Emotional Representations Scores Across CSI-IASP Classification Groups", "description": "Emotional responses to illness will be assessed using the Emotional Representations subscale of the Revised Illness Perception Questionnaire (IPQ-R). This subscale consists of 6 items scored from 1 to 5, yielding a total score ranging from 6 to 30. Higher scores indicate stronger negative emotional responses to illness, whereas lower scores indicate fewer negative emotional responses. Scores will be compared across four groups defined by CSI classification (below 40 versus 40 or higher) and IASP classification (not meeting criteria versus at least possible nociplastic pain). Multivariable linear regression will be used to assess group differences after adjustment for pain severity (NRS) and neck-related disability (NDI). Adjusted mean differences and 95% confidence intervals will be reported.", "timeFrame": "baseline" }, { "measure": "Agreement Between CSI Classification and Probable IASP Nociplastic Pain", "description": "An additional agreement analysis will be conducted using only the probable nociplastic pain category as the positive IASP classification. Participants not meeting the IASP criteria and those classified as having possible nociplastic pain will form the comparison category. CSI scores will be classified as below 40 or 40 and above. Agreement will be quantified using Cohen's kappa coefficient with a 95% confidence interval.", "timeFrame": "baseline" } ], "otherOutcomes": [ { "measure": "IPQ-R Consequences Score Across CSI-IASP Classification Groups", "description": "Perceived consequences of illness will be assessed using the Consequences subscale of the Revised Illness Perception Questionnaire (IPQ-R). This subscale consists of 6 items scored from 1 to 5, yielding a total score ranging from 6 to 30. Higher scores indicate greater perceived negative consequences of illness, while lower scores indicate fewer perceived negative consequences. Scores will be compared across the four groups defined by CSI (below 40 versus 40 or higher) and IASP (not meeting criteria versus at least possible nociplastic pain) classifications as an exploratory analysis.", "timeFrame": "baseline" } ] }, "eligibility": { "eligibilityCriteria": "Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Neck pain lasting longer than three months.\n* Diagnosis of chronic cervical myofascial pain syndrome established by a Physical Medicine and Rehabilitation specialist.\n* Willingness to participate and provision of written informed consent.\n\nExclusion Criteria\n\n* Cervical radiculopathy, myelopathy, or another neurological disorder identified as the primary cause of neck pain.\n* Fracture, infection, malignancy, or active inflammatory rheumatic disease explaining the neck pain.\n* Diagnosis of fibromyalgia.\n* Open wounds, active skin disease, or infection in the examination area that prevents clinical assessment.\n* Cognitive impairment or an active severe psychiatric condition that prevents understanding the questions, providing reliable responses, or participating in the clinical examination.", "healthyVolunteers": false, "sex": "ALL", "minimumAge": "18 Years", "stdAges": [ "ADULT", "OLDER_ADULT" ], "studyPopulation": "The study population will consist of 150 adults aged 18 years or older diagnosed with chronic cervical myofascial pain syndrome who attend the Physical Medicine and Rehabilitation Outpatient Clinic at Mardin Training and Research Hospital, Türkiye. Eligible participants will have neck pain lasting longer than three months. All participants will undergo a single-visit assessment including IASP clinical nociplastic pain classification, the Central Sensitization Inventory (CSI), the Neck Disability Index (NDI), and the Revised Illness Perception Questionnaire (IPQ-R). Patients will be categorized according to their CSI and IASP classifications. No healthy control group will be included.", "samplingMethod": "NON_PROBABILITY_SAMPLE" }, "countries": [ "Turkey (Türkiye)" ], "has_results": false }, { "id": "NCT07048366", "title": "Mindfulness-based Rehabilitation in a University Museum Setting to Reduce Pain and Improve Quality of Life in Women With Fibromyalgia: a Randomized Controlled Trial", "status": { "statusVerifiedDate": "2026-10", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2025-11-27", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2026-07-31", "type": "ACTUAL" }, "completionDateStruct": { "date": "2026-07-31", "type": "ACTUAL" }, "studyFirstSubmitDate": "2025-06-24", "studyFirstSubmitQcDate": "2025-06-24", "studyFirstPostDateStruct": { "date": "2025-07-02", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-10-28", "lastUpdatePostDateStruct": { "date": "2026-10-29", "type": "ACTUAL" } }, "design": { "studyType": "INTERVENTIONAL", "phases": [ "NA" ], "designInfo": { "allocation": "RANDOMIZED", "interventionModel": "PARALLEL", "interventionModelDescription": "Participants with fibromyalgia will be randomly assigned in a 1:1 ratio to either the integrated rehabilitation program conducted in the museum setting or to a control group receiving the same mindfulness-based intervention at the CARES (Center for Disability, Rehabilitation and Sports Medicine), at University . Both groups will be followed in parallel for the study duration.", "primaryPurpose": "TREATMENT", "maskingInfo": { "masking": "DOUBLE", "maskingDescription": "This study employs a double-blind design where both participants and outcome assessors are masked to the intervention assignment. Participants are unaware of their group allocation (treatment vs. control). Personnel collecting and analyzing outcome data will also be blinded to group assignment to minimize bias. The care providers delivering the intervention, due to the nature of the behavioral therapy, may not be fully masked.", "whoMasked": [ "PARTICIPANT", "OUTCOMES_ASSESSOR" ] } }, "enrollmentInfo": { "count": 65, "type": "ACTUAL" } }, "summary": { "briefSummary": "This research study aims to investigate whether art and integrative medicine, within a unique setting like a university museum, can offer a new approach to help women suffering from fibromyalgia. Fibromyalgia is a chronic condition causing widespread pain and other symptoms such as fatigue and sleep disturbances. The question this study seeks to answer is: Is an 8-week rehabilitation program, based on mindfulness and body awareness techniques, conducted at the University Museum of the G. d'Annunzio University, effective in reducing pain and improving the quality of life (physical and mental well-being) and coping abilities in female fibromyalgia patients? Participants will be randomly assigned to either receive this program in the museum or to a control group.", "detailedDescription": "Fibromyalgia Syndrome (FM) is a complex and debilitating chronic musculoskeletal pain condition characterized by widespread pain, tenderness, and a myriad of associated symptoms including profound fatigue, sleep disturbances, cognitive impairment (often referred to as \"fibro-fog\"), and affective disorders such as anxiety and depression. Its prevalence is significant, affecting a substantial portion of the global population, predominantly women. Diagnosis relies on established criteria (e.g., ACR 1990, revised 2010/2011, and 2016 criteria), emphasizing the presence of widespread pain and symptom severity. The underlying pathophysiology is multifactorial, involving neuro-immuno-endocrine dysregulation, central sensitization (an amplification of pain signals in the central nervous system), and in some cases, small fiber neuropathy, leading to an altered pain perception.\n\nGiven its complex nature, a purely pharmacological approach to fibromyalgia is often insufficient. Current evidence strongly supports a multifactorial therapeutic strategy that integrates pharmacological treatments with non-pharmacological interventions, including complementary therapies and integrated medicine. This study introduces a novel, non-pharmacological integrated rehabilitation pathway designed to address the multifaceted symptoms of fibromyalgia.\n\nThis randomized controlled trial investigates the efficacy of a unique integrated rehabilitation program delivered within the evocative environment of a university museum. The program leverages the principles of art therapy and neuroaesthetics, combined with established mindfulness and body awareness techniques, to create a holistic and immersive healing experience. The rationale is rooted in the understanding that engagement with art and culturally enriching environments can positively influence brain function and emotional states. Specifically, interactions within a museum setting are hypothesized to:\n\n* Stimulate the brain's reward system, fostering positive emotions and reducing pain perception.\n* Modulate cortical maps, potentially normalizing altered somatosensory processing observed in fibromyalgia.\n* Provide a powerful distraction from chronic pain and discomfort, shifting focus towards aesthetic appreciation and inner experiences.\n* Enhance emotional regulation and promote self-efficacy in managing symptoms.\n* The museum itself acts as a \"setting of care,\" providing a calming and inspiring atmosphere that can amplify the therapeutic effects of rehabilitation, reducing stress and promoting overall well-being.\n\nThe intervention consists of an 8-week program with weekly 60-minute sessions. Participants in the experimental group engage in a structured curriculum that integrates various techniques, including conscious breathing exercises, body scan meditation, mindfulness walking within the museum's exhibition spaces, specific stretching and mobilization techniques, and gratitude and recognition exercises, all framed by the artistic and cultural context of the university museum. This approach aims to cultivate body awareness, reduce pain catastrophizing, and improve emotional coping mechanisms.\n\nParticipants with a confirmed diagnosis of fibromyalgia will be randomly assigned (1:1 ratio) to either this museum-based integrated therapy group or a control group (e.g., a waitlist for conventional treatments). The study is designed to rigorously evaluate the impact of this innovative approach on primary and secondary outcome measures, including pain reduction, improvement in quality of life, and enhanced coping strategies. Ethical considerations, including informed consent and participant safety, are paramount, and the study adheres to the principles of the Declaration of Helsinki. The sample size has been determined through a power calculation to ensure statistical validity, aiming to detect a clinically significant reduction in pain as the primary outcome.\n\nThis study seeks to provide robust evidence for the therapeutic potential of art and integrated medicine in the management of fibromyalgia, potentially offering a valuable, accessible, and non-pharmacological addition to existing treatment paradigms." }, "outcomes": { "primaryOutcomes": [ { "measure": "Pain Reduction", "description": "Reduction in musculoskeletal pain intensity, evaluated by Visual Analogue Scale (VAS) for musculoskeletal pain (0-10 cm score).", "timeFrame": "Baseline (T0), End of treatment (T1, after 8 weeks), Follow-up (T2, 4 weeks after end of treatment)." } ], "secondaryOutcomes": [ { "measure": "Quality of Life Improvement", "description": "Improvement in the physical and mental dimensions of quality of life. Metric: SF-12 (Short Form-12 Health Survey) total score (0-100).", "timeFrame": "Baseline (T0), End of treatment (T1, after 8 weeks), Follow-up (T2, 4 weeks after end of treatment)." }, { "measure": "Fibromyalgia Impact on Daily Life", "description": "Changes in the impact of fibromyalgia on daily activities and overall functioning. Metric: Fibromyalgia Impact Questionnaire (FIQ) scores (ranging from 0 to approximately 100).", "timeFrame": "Baseline (T0), End of treatment (T1, after 8 weeks), Follow-up (T2, 4 weeks after end of treatment)." }, { "measure": "Global Symptom Severity", "description": "Changes in the overall severity of symptoms associated with fibromyalgia. Metric: Fibromyalgia Status Scale (FSS) scores (0-10 for each item).", "timeFrame": "Baseline (T0), End of treatment (T1, after 8 weeks), Follow-up (T2, 4 weeks after end of treatment)." }, { "measure": "Anxiety Levels", "description": "Changes in anxiety symptoms. Metric: Zung Self-Rating Anxiety Scale (SAS) score (20-80).", "timeFrame": "Baseline (T0), End of treatment (T1, after 8 weeks), Follow-up (T2, 4 weeks after end of treatment)." }, { "measure": "Depressive Symptoms", "description": "Changes in depressive symptoms. Metric: Zung Self-Rating Depression Scale (SDS) score (20-80).", "timeFrame": "Baseline (T0), End of treatment (T1, after 8 weeks), Follow-up (T2, 4 weeks after end of treatment)." }, { "measure": "Emotional State", "description": "Evaluation of participants' emotional state. Metric: Delighted Terrible Face scale.", "timeFrame": "Baseline (T0), End of treatment (T1, after 8 weeks), Follow-up (T2, 4 weeks after end of treatment)." }, { "measure": "Life Satisfaction", "description": "Changes in overall satisfaction with life. Metric: Satisfaction with Life Scale (SWLS) score (5-35).", "timeFrame": "Baseline (T0), End of treatment (T1, after 8 weeks), Follow-up (T2, 4 weeks after end of treatment)." }, { "measure": "Positive and Negative Emotions", "description": "Changes in positive and negative affect. Metric: Positive and Negative Affect Schedule (PANAS) scores (10-50 per dimension).", "timeFrame": "Baseline (T0), End of treatment (T1, after 8 weeks), Follow-up (T2, 4 weeks after end of treatment)." }, { "measure": "Emotional Regulation Strategies", "description": "Changes in emotional regulation processes, specifically reappraisal and suppression. Metric: Emotional Regulation Questionnaire (ERQ) scores (typical range: 6-42 for Reappraisal, 4-28 for Suppression).", "timeFrame": "Baseline (T0), End of treatment (T1, after 8 weeks), Follow-up (T2, 4 weeks after end of treatment)." } ] }, "eligibility": { "eligibilityCriteria": "Inclusion Criteria:\n\n* Female patients\n* Diagnosis of Fibromyalgia Syndrome according to 2016 criteria\n* Muscle pain Visual Analogue Scale (VAS) score greater than 5 in the last month\n* Age between 18 and 60 years\n* Absence of other chronic, widespread, or localized painful conditions\n* Absence of any other condition that might affect pain perception (e.g., diabetes)\n* Absence of neurological or psychiatric conditions that might affect study participation\n* Absence of current or past oncological diseases in the last 5 years\n* Absence of corticosteroid therapy in the last 30 days\n* Absence of NSAID (Non-Steroidal Anti-Inflammatory Drugs) and analgesic therapy in the last 4 days\n* Absence of pregnancy and breastfeeding for the entire duration of observation\n* Signed informed consent\n\nExclusion Criteria:\n\n* Presence of severe scoliosis or kyphoscoliosis\n* Previous spinal surgeries or sequelae of vertebral fractures\n* Presence of lumbosciatalgia (sciatica-like pain in the lower back) at the time of the visit\n* Presence of osteoporosis\n* Presence of neurological or psychiatric conditions\n* Current therapy with corticosteroids and/or NSAIDs and/or analgesics\n* Pregnancy or breastfeeding", "healthyVolunteers": false, "sex": "FEMALE", "genderBased": true, "genderDescription": "Only female participants with a diagnosis of Fibromyalgia Syndrome are eligible to participate.", "minimumAge": "18 Years", "maximumAge": "60 Years", "stdAges": [ "ADULT" ] }, "countries": [ "Italy" ], "has_results": false }, { "id": "NCT07874230", "title": "Predictors of Pressure Pain Thresholds", "status": { "statusVerifiedDate": "2026-10", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2023-11-04", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2025-07-04", "type": "ACTUAL" }, "completionDateStruct": { "date": "2025-11-04", "type": "ACTUAL" }, "studyFirstSubmitDate": "2026-10-08", "studyFirstSubmitQcDate": "2026-10-08", "studyFirstPostDateStruct": { "date": "2026-10-14", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-10-26", "lastUpdatePostDateStruct": { "date": "2026-10-29", "type": "ACTUAL" } }, "design": { "studyType": "OBSERVATIONAL", "patientRegistry": false, "designInfo": { "observationalModel": "COHORT", "timePerspective": "CROSS_SECTIONAL" }, "enrollmentInfo": { "count": 67, "type": "ACTUAL" } }, "summary": { "briefSummary": "Objective: This cross-sectional study aimed to determine whether office-related strain risk, head and neck working posture, and weekly screen time predict the mean pressure pain threshold (PPT) at latent trigger points (LTrPs) in the upper trapezius muscle among office workers. A secondary aim was to examine relationships among LTrP characteristics, ergonomic risk factors, postural parameters, and demographic variables.\n\nInclusion criteria: Ages 25-44 years, BMI 18.5-29.9 kg/m², presence of at least one LTrP in the upper trapezius Exclusion criteria: Active trigger points, history of head/neck/shoulder surgery, pain medication use in last 24 hours, recent myofascial pain treatment Assessments Conducted: Demographics \\& Time Variables: Age, gender, BMI, years of employment, weekly screen time (phone + computer), daily sitting time LTrP Identification: Manual pincer palpation by experienced physiotherapist (12 years experience) PPT Measurement: Calibrated Baseline Algometer at the most painful LTrP and a non-trigger point site Ergonomic Risk: Rapid Office Strain Assessment (ROSA)\n\nPostural Assessment: Photogrammetry measuring:\n\nCraniocervical Angle (CCA) Cervicothoracic Angle (CTA) All assessments were conducted one hour after participants started working to allow for postural adaptation.", "detailedDescription": "Study Design This is a cross-sectional, observational study conducted at Dokuz Eylul University between October 2023 and August 2024. Ethical approval was obtained from the Institutional Noninvasive Research Ethics Board (Approval number: 2023/31-23, 4 October 2023), and written informed consent is obtained from all participants. All procedures comply with the Declaration of Helsinki.\n\nRecruitment and Screening Office workers at Dokuz Eylul University are recruited through workplace announcements. Eligibility is determined in a two-stage screening process. Participants receive brief education on differentiating active from latent trigger points, and those reporting spontaneous pain are excluded.\n\nStudy Procedures All assessments are conducted one hour after participants begin their workday to allow for postural adaptation to their workspace. Each session lasts approximately 40 minutes.\n\nLatent trigger points (LTrPs) are identified by manual pincer palpation of the bilateral upper trapezius by an experienced physiotherapist (12 years of clinical experience). An LTrP is confirmed by localized tenderness, a palpable taut band, and a hypersensitive spot eliciting referred pain on compression without spontaneous symptoms. The most painful LTrP is marked, and the count is verified by repeat palpation.\n\nPressure pain threshold (PPT) is measured with a calibrated Baseline Algometer at the most painful LTrP and at a standardized non-trigger point site. Pressure is increased at approximately 1 kg/cm² per second, and the procedure is repeated three times at 30-second intervals. The algometer display is concealed from the examiner.\n\nErgonomic risk is assessed with the Rapid Office Strain Assessment (ROSA), which evaluates chair, monitor, telephone, keyboard and mouse setup and yields a cumulative score.\n\nHead and neck working posture is assessed by photogrammetry. Lateral photographs of participants during their usual work tasks are taken three times at one-minute intervals after a 5-minute adjustment period. The craniocervical angle (CCA) and cervicothoracic angle (CTA) are measured digitally by an evaluator blinded to all other participant data, and the mean of three measurements is used.\n\nWeekly phone screen time is obtained from device digital wellbeing trackers; computer use and daily sitting time are self-reported.\n\nStatistical Analysis Plan The sample size is 67 participants. Analyses are performed in SPSS 26.0, and normality is assessed with the Kolmogorov-Smirnov test and descriptive statistics. The primary analysis is a hierarchical multiple regression testing whether ROSA score and CTA predict mean PPT at LTrPs after controlling for demographic variables (Step 1: age, gender, BMI, years of employment; Step 2: ROSA score and CTA), with significance set at p \\< 0.05. Multicollinearity is checked with VIF (\\< 10) and tolerance (\\> 0.2).\n\nSecondary analyses use Pearson correlation (and Spearman correlation for the number of LTrPs) to examine relationships among PPT, ROSA score, CCA, CTA, weekly screen time, daily sitting time, years of employment, and demographic variables." }, "outcomes": { "primaryOutcomes": [ { "measure": "Mean Pressure Pain Threshold at Latent Trigger Points", "timeFrame": "baseline (single time point)" } ] }, "eligibility": { "eligibilityCriteria": "Inclusion Criteria:\n\n* Office workers aged between 25 and 44 years\n* Body mass index (BMI) between 18.5 and 29.9 kg/m²\n* Presence of at least one latent trigger point (LTrP) in the upper trapezius muscle on either side\n* Voluntary written informed consent\n\nExclusion Criteria:\n\n* History of head, neck, or shoulder surgery\n* History of any diagnosis or condition that may be confused with myofascial pain (e.g., fibromyalgia, cervical radiculopathy)\n* Any diagnosis or condition that may alter pain sensation or tissue characteristics (e.g., peripheral neuropathy, diabetes mellitus)\n* Presence of an active trigger point (spontaneous pain) in the upper trapezius muscle\n* Use of painkillers or anti-inflammatory drugs within the last 24 hours\n* Treatment for myofascial pain within the last 3 months\n* BMI below 18.5 or above 29.9 kg/m²\n* Pregnancy", "healthyVolunteers": true, "sex": "ALL", "minimumAge": "25 Years", "maximumAge": "44 Years", "stdAges": [ "ADULT" ], "studyPopulation": "office workers", "samplingMethod": "NON_PROBABILITY_SAMPLE" }, "countries": [ "Turkey (Türkiye)" ], "has_results": false }, { "id": "NCT03058003", "title": "Correlation Between Central Sensitization Inventory and Posturographic Data", "status": { "statusVerifiedDate": "2021-08", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2016-05", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2018-01", "type": "ACTUAL" }, "completionDateStruct": { "date": "2021-04", "type": "ACTUAL" }, "studyFirstSubmitDate": "2017-02-16", "studyFirstSubmitQcDate": "2017-02-16", "studyFirstPostDateStruct": { "date": "2017-02-20", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-10-21", "lastUpdatePostDateStruct": { "date": "2026-10-23", "type": "ACTUAL" } }, "design": { "studyType": "OBSERVATIONAL", "patientRegistry": false, "designInfo": { "observationalModel": "CASE_CONTROL", "timePerspective": "CROSS_SECTIONAL" }, "enrollmentInfo": { "count": 180, "type": "ACTUAL" } }, "summary": { "briefSummary": "To investigate the use of balance as a screening tool for Central Sensitization, a condition of the nervous system that is associated with the development and maintenance of chronic pain. This is done by comparing the scores of a gold standard screening tool (the Central Sensitization Inventory) with balance data.", "detailedDescription": "First, subjects will be asked to answer a brief medical questionnaire pertaining their general health status: since some of the subjects will be self-assessed to be \"healthy\" (no medical examination will be conducted to determine if this is indeed the case), the questionnaire will be used to determine if there are any possible known causes of poor balance performance. The questionnaire will not constitute an inclusion/exclusion criterion, it just has a classification purpose.\n\nSubjects will then be asked to fill in the Central Sensitization Inventory (CSI), scoring each of the 25 items on a scale from 0 (never) to 4 (always).\n\nThen, subjects will stand for 2 minutes on a compliant surface (a 4\" tall foam cushion of known mechanical properties) to \"learn\" how to stand on it. Afterward, they will undergo posturography testing using the extended modified Clinical Testing of Sensory Integration in Balance (ext\\_mCTSIB) protocol: the subjects will be required to stand on a hard or compliant surface in a comfortable posture, feet shoulder width, with eyes open or closed, arms to the side and free to move, gazing forward, and breathing normally, with head straight, turned right or left, flexed or extended." }, "outcomes": { "primaryOutcomes": [ { "measure": "Stability Score", "description": "The Stability Score (calculated as percentage ratio of the actual sway and the theoretical limit of stability) will be used to investigate if there is any difference between healthy controls and subjects affected by chronic pain. Statistical tools such t-tests and correlation coefficients will be used for assess if there is a difference between the two groups", "timeFrame": "immediately after data collection" }, { "measure": "CSI", "description": "The sum of all the answers to the Central Sensitization Inventory will be used to investigate if there is any difference between healthy controls and subjects affected by chronic pain. Statistical tools such t-tests and correlation coefficients will be used for assess if there is a difference between the two groups", "timeFrame": "immediately after data collection" } ], "secondaryOutcomes": [ { "measure": "CSI-SS", "description": "Correlation between the Stability Score and the CSI result for each individual to determine if balance is an indicator of Central Nervous System Sensitization", "timeFrame": "immediately after data collection" } ] }, "eligibility": { "eligibilityCriteria": "Inclusion Criteria:\n\n* Adults, self assessed to be in good health, or medically diagnosed with any of the following pathologies: Chronic nonspecific low back pain (CNSLBP), Fibromyalgia (FM), Cervicogenic Headche (CH), Chronic Tension Type Headache (CTT), Irritable Bowel Syndrome (IBS), Whiplash Associated Disorder (WAD), Temporomandibular Disorder (TMD)\n\nExclusion Criteria:\n\n* Pregnant women will be excluded, as will be minors", "healthyVolunteers": true, "sex": "ALL", "minimumAge": "18 Years", "maximumAge": "65 Years", "stdAges": [ "ADULT", "OLDER_ADULT" ], "studyPopulation": "Adults, self assess to be in good health or diagnosed with Central Nervous System Sensitization", "samplingMethod": "NON_PROBABILITY_SAMPLE" }, "countries": [ "Australia", "United States" ], "has_results": false }, { "id": "NCT07904351", "title": "Toward Biomarker-Guided Fibromyalgia Treatment With Non-Invasive Vagus Nerve Stimulation", "status": { "statusVerifiedDate": "2026-09", "overallStatus": "NOT_YET_RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2026-10-15", "type": "ESTIMATED" }, "primaryCompletionDateStruct": { "date": "2029-07-30", "type": "ESTIMATED" }, "completionDateStruct": { "date": "2029-08-31", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2026-10-23", "studyFirstSubmitQcDate": "2026-10-23", "studyFirstPostDateStruct": { "date": "2026-10-29", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-10-23", "lastUpdatePostDateStruct": { "date": "2026-10-29", "type": "ACTUAL" } }, "design": { "studyType": "INTERVENTIONAL", "phases": [ "NA" ], "designInfo": { "allocation": "RANDOMIZED", "interventionModel": "PARALLEL", "interventionModelDescription": "8-weeks of clinical study with a total of 105 subjects, randomized into 2 groups (70 subjects in tVNS and 35 subjects in control group)", "primaryPurpose": "TREATMENT", "maskingInfo": { "masking": "DOUBLE", "whoMasked": [ "PARTICIPANT", "INVESTIGATOR" ] } }, "enrollmentInfo": { "count": 105, "type": "ESTIMATED" } }, "summary": { "briefSummary": "Fibromyalgia is a syndrome with clinical symptoms that affect multiple systems of the body. Although basic science research and clinical research trials have been carried out, the cause and the mechanism of fibromyalgia are still unknown. The goal of current medical treatment is to relieve symptoms and improve quality of life. Recent clinical and experimental studies have shown that stimulation of the vagus nerve has a potential to help pain syndromes. In this study, we aim to evaluate the effects of using transcutaneous vagus nerve stimulation (tVNS) on treating pain and other symptoms in fibromyalgia patients. We will do this by using the VagaCalm device.", "detailedDescription": "Fibromyalgia is a chronic condition that can cause widespread pain, fatigue, sleep problems, anxiety, and depression. While current treatments can help manage symptoms, many people continue to experience significant discomfort and reduced quality of life.\n\nThis study will evaluate whether transcutaneous vagus nerve stimulation (tVNS), a non-invasive therapy that delivers mild electrical stimulation to the outer ear, can help reduce pain and other symptoms in people with fibromyalgia. The vagus nerve helps regulate communication between the brain and the body and may play a role in pain processing.\n\nA total of 105 participants will take part in this 6-week study. Participants will receive either active tVNS treatment or a sham (inactive) treatment for comparison. Researchers will assess changes in pain and other fibromyalgia-related symptoms using questionnaires and pain sensitivity testing. Additional assessments will include pressure pain testing, mechanical pain sensitivity testing using Von Frey filaments, dietary questionnaires, the Bristol Stool Chart, and stool sample collection.\n\nThe study will also measure levels of intestinal alkaline phosphatase (IAP) in stool samples to investigate whether IAP could serve as a biomarker for fibromyalgia and whether it may be associated with symptom severity or response to treatment. Participants will complete a follow-up phone call approximately 8 weeks after enrollment to assess pain levels and any side effects.\n\nThe findings may improve understanding of fibromyalgia, help identify potential biological markers of the condition, and evaluate a non-invasive treatment approach for symptom management." }, "outcomes": { "primaryOutcomes": [ { "measure": "Short-Form McGill Pain Questionnaire-2 (SF-MPQ-2) Score", "description": "The SF-MPQ-2 assesses pain quality and intensity across multiple pain domains and includes a general pain intensity rating. Participants rate pain severity on a scale from 0 (none) to 10 (worst possible). Higher scores indicate greater pain severity.", "timeFrame": "Week 0 and Week 6" } ], "secondaryOutcomes": [ { "measure": "Multidimensional Fatigue Inventory", "description": "The Multidimensional Fatigue Inventory (MFI-20) is a 20-item self-report questionnaire that assesses general fatigue, physical fatigue, mental fatigue, reduced motivation, and reduced activity. Participants rate statements using a 5-point Likert scale. Higher total scores indicate greater fatigue.", "timeFrame": "Week 0 and Week 6" }, { "measure": "Revised Fibromyalgia Impact Questionnaire (FIQR) Total Score", "description": "The Revised Fibromyalgia Impact Questionnaire (FIQR) is a 21-item self-report measure assessing fibromyalgia-related function, overall impact, and symptoms during the previous 7 days. Total scores range from 0 to 100, with higher scores indicating greater fibromyalgia symptom burden and functional impairment.", "timeFrame": "Week 0 and Week 6" }, { "measure": "Supplemental Gastrointestinal Symptom Questionnaire Score", "description": "The Supplemental Gastrointestinal Symptom Questionnaire assesses gastrointestinal symptoms, including abdominal pain, bloating, abnormal bowel movements, irritable bowel syndrome diagnosis, and stool characteristics. Higher scores indicate greater gastrointestinal symptom burden.", "timeFrame": "Week 0 and Week 6" }, { "measure": "Empirical Dietary Inflammatory Index (EDII) Score", "description": "The Empirical Dietary Inflammatory Index (EDII) is a dietary assessment questionnaire that evaluates the inflammatory potential of dietary intake based on the frequency of consumption of specific food and beverage categories. Higher scores indicate a more pro-inflammatory dietary pattern.", "timeFrame": "Week 0 and Week 6" }, { "measure": "Medical Outcomes Study Questionnaire Short Form 36 (SF-36)", "description": "The SF-36 is a 36-item self-report measure of health-related quality of life assessing physical functioning, role limitations, bodily pain, general health, vitality, social functioning, emotional well-being, and mental health. Higher scores indicate better health status and quality of life.", "timeFrame": "Week 0 and Week 6" }, { "measure": "Medical Outcomes Study (MOS) Sleep Scale Score", "description": "The MOS Sleep Scale is a 12-item self-report questionnaire that assesses sleep disturbance, sleep adequacy, daytime somnolence, sleep quantity, and other sleep-related problems experienced during the previous 4 weeks. Higher scores indicate greater sleep disturbance and poorer sleep quality.", "timeFrame": "Week 0 and Week 6" }, { "measure": "Blood inflammation marker", "description": "Collect blood samples for cytokine level assessment.", "timeFrame": "Week 0 and Week 6" }, { "measure": "Assessment of Gut Microbiome Changes Through Genomic and Phenotypic Analysis", "description": "Collect stool samples to analyze bacterial composition and metabolomic profiles of the gut microbiome.", "timeFrame": "Week 0 and Week 6" } ] }, "eligibility": { "eligibilityCriteria": "Inclusion Criteria:\n\n1. Subject is 18 to 80 years old, including both male and female subjects.\n2. Subject has a documented diagnosis of FM for at least three months. This requirement is to avoid the uncertainty of an unstable pain condition and to minimize the study variation.\n3. Subject has a pain score of 4 or above (numeric pain score: 0 - 10 from no pain to worst pain).\n\nExclusion Criteria:\n\n1. Subject has current cardiac arrhythmia or had implanted cardiac pacemaker or AICD device.\n2. Subject has major psychiatric disorder required hospitalization in the last 3 months.\n3. Subject has active infection at the site of device application.\n4. Subject has recurrent syncope symptoms within the past three months.\n5. Subject is pregnant.\n6. Subject has had VNS treatment within the past two months.", "healthyVolunteers": false, "sex": "ALL", "minimumAge": "18 Years", "maximumAge": "80 Years", "stdAges": [ "ADULT", "OLDER_ADULT" ] }, "countries": [ "United States" ], "has_results": false }, { "id": "NCT07894588", "title": "Effects of Adding Vagal Neuromodulation to Manual Therapy in Women With Fibromyalgia", "status": { "statusVerifiedDate": "2026-10", "overallStatus": "NOT_YET_RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2026-11-02", "type": "ESTIMATED" }, "primaryCompletionDateStruct": { "date": "2027-02-01", "type": "ESTIMATED" }, "completionDateStruct": { "date": "2027-03-09", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2026-10-17", "studyFirstSubmitQcDate": "2026-10-17", "studyFirstPostDateStruct": { "date": "2026-10-26", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-10-17", "lastUpdatePostDateStruct": { "date": "2026-10-26", "type": "ACTUAL" } }, "design": { "studyType": "INTERVENTIONAL", "phases": [ "NA" ], "designInfo": { "allocation": "RANDOMIZED", "interventionModel": "PARALLEL", "interventionModelDescription": "This is a two-arm, parallel-group, randomized, sham-controlled trial. Female patients diagnosed with fibromyalgia will be randomly allocated in a 1:1 ratio, using opaque sealed envelopes, to either the study group (manual therapy plus active taVNS combined with diaphragmatic breathing) or the sham control group (manual therapy plus sham taVNS). Outcomes will be assessed at baseline and after the intervention period.", "primaryPurpose": "TREATMENT", "maskingInfo": { "masking": "SINGLE", "whoMasked": [ "OUTCOMES_ASSESSOR" ] } }, "enrollmentInfo": { "count": 44, "type": "ESTIMATED" } }, "summary": { "briefSummary": "The aim of this study is to investigate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) added to manual therapy on pain, autonomic nervous system function, and illness perception in female patients diagnosed with fibromyalgia, using a randomized sham-controlled design.", "detailedDescription": "Fibromyalgia syndrome (FMS) is a disease characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive impairment, and it markedly reduces quality of life. It is more prevalent in women, and it is thought to affect approximately 2-3% of the general population.\n\nAlthough the etiology and pathogenesis of widespread pain are not yet known, it is thought to have a multifactorial basis. In this context, the interaction of various biopsychosocial mechanisms, such as increased central nervous system sensitivity (central sensitization), neurohormonal dysregulation, genetic predisposition, and environmental stress factors, is emphasized.\n\nChronic widespread pain is the most important reason for presentation in fibromyalgia (FM). According to the FM classification criteria reported by the American College of Rheumatology (ACR), in addition to a history of chronic widespread pain, the presence of tenderness at 11 or more of 18 specific anatomical sites on examination is required.\n\nAlthough many people experience an illness during their lifetime, the experience is not the same for every individual. People try to make sense of their illness in light of their values, beliefs, and needs. Illness perception is the cognitive representation of the illness state.\n\nThe vagus nerve, the body's \"great protector,\" comprises a mixed neuro-endocrine-immune network that maintains homeostasis. With reciprocal neural connections to multiple regions of the brain, the vagus nerve serves as a control center that integrates sensory information and provides appropriate feedback responses. Recent studies show that the vagus nerve is involved in the regulation of inflammation, mood, and pain, all of which can be modulated by vagus nerve stimulation. Vagus nerve stimulation, together with the broad vagal neural network, may produce a neuromodulatory effect that activates certain natural protective pathways to restore health. Non-invasive transcutaneous devices stimulate the vagus nerve via the auricular route or at the carotid. They are also used in the treatment of various conditions such as epilepsy, pain, and headache. A medical device has made it possible to stimulate the auricular branch of the vagus nerve without any surgery. As a result, an increase in pain threshold and a decrease in mechanical pain sensitivity have been found.\n\nThe effect of repeated-session stimulation of the auricular and cervical vagal branches on FM symptomatology has not been tested to date in a randomized or sham-controlled study. A double-blind, sham-controlled study initiated in 2024 at the National and Kapodistrian University of Athens, and still ongoing, explicitly cited this gap as its rationale and stated that it aims to test, for the first time, the effect of multi-session tVNS on pain and quality of life in FM patients. This shows that, although vagus nerve stimulation is regarded as a promising method in the treatment of fibromyalgia, direct clinical evidence on the subject remains quite limited, and current knowledge is largely based on inferences from closely related conditions.\n\nThe literature on the effects of manual therapy in FM carries a similar uncertainty. A systematic review published in Pain Physician, which pooled seven randomized controlled trials including a total of 368 patients, reported that various manual therapy approaches, particularly myofascial release, showed partial positive effects on pain, disease impact, and quality of life. However, it emphasized that the level of evidence ranged from very low to moderate, and that no definitive judgment on efficacy could be reached because of inconsistency between studies. Although individual studies exist showing that connective tissue massage-based manual therapy applications reduce neck pain in women with FM, it remains largely unclear in the literature which manual therapy approach is superior and how the physiological mechanisms underlying this effect operate. Moreover, no study has been found that applies manual therapy and vagus nerve stimulation together and examines the possible combined effect of these two methods.\n\nThe aim of this study is to investigate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) added to manual therapy on pain, autonomic nervous system function, and illness perception in female patients diagnosed with fibromyalgia, using a randomized sham-controlled design.\n\nA comprehensive systematic review published in 2026 clearly demonstrated that the methodological quality of existing taVNS studies is inadequate and that there are no randomized controlled trials examining its combination with standard clinical practices such as manual therapy. This critical gap in the literature constitutes the main motivation for the study.\n\nIn addition, recently published studies with similar designs, in which the combination of taVNS and manual therapy was tested in temporomandibular disorders and taVNS was applied alone in FMS, strongly support the need to systematically investigate this combination in the FMS population.\n\nAnother aim is to determine the additional contribution of vagal neuromodulation (taVNS + diaphragmatic breathing) to manual therapy, to test whether changes in HRV parameters mediate FIQ-R improvement (mediation analysis), and to relate changes in illness perception, measured with the Brief IPQ, to clinical outcomes." }, "outcomes": { "primaryOutcomes": [ { "measure": "Pressure Pain Threshold (PPT)", "description": "Pressure pain threshold will be measured with a manual pressure algometer at the 18 tender points defined in the ACR fibromyalgia criteria (bilateral occiput, low cervical, trapezius, supraspinatus, second rib, lateral epicondyle, gluteal, greater trochanter, and knee). Pressure will be applied perpendicular to the skin at a steady rate, and the participant will report the moment the pressure first becomes painful. The value at that moment will be recorded at each point. The total algometric score will be calculated as the sum of the values from all 18 points. Higher scores indicate a higher pain threshold (lower pain sensitivity), and an increase from baseline indicates improvement. Measurements will be performed under standardized conditions at baseline and after the 8-week intervention.", "timeFrame": "Baseline and 8 weeks (after the intervention period)" } ], "secondaryOutcomes": [ { "measure": "Short-Form McGill Pain Questionnaire (SF-MPQ)", "description": "The SF-MPQ is a 15-item questionnaire assessing the sensory and affective dimensions of pain. Participants rate each descriptor on a 4-point scale (0 = none, 1 = mild, 2 = moderate, 3 = severe). The total score ranges from 0 to 45. Higher scores indicate greater pain. The Turkish validated version will be used.", "timeFrame": "Baseline and 8 weeks" }, { "measure": "Heart Rate Variability (HRV)", "description": "Autonomic nervous system function will be assessed objectively by heart rate variability. R-R intervals will be recorded with a Polar H10 chest strap and analyzed with Kubios HRV Scientific Lite software. Time-domain parameters (e.g., RMSSD, SDNN) and frequency-domain parameters (e.g., LF, HF, LF/HF ratio) will be calculated in line with the Task Force standards. Higher RMSSD and HF values indicate greater parasympathetic (vagal) activity.", "timeFrame": "Baseline and 8 weeks" }, { "measure": "Brief Illness Perception Questionnaire (Brief IPQ)", "description": "The Brief IPQ assesses the participant's cognitive and emotional representation of her illness. Eight items (consequences, timeline, personal control, treatment control, identity, concern, coherence, emotional response) are rated from 0 to 10, and the ninth item is an open-ended question about perceived causes. The total score of the first eight items ranges from 0 to 80 (after reverse-scoring the control and coherence items). Higher scores indicate a more threatening perception of the illness.", "timeFrame": "Baseline and 8 weeks" }, { "measure": "Revised Fibromyalgia Impact Questionnaire (FIQ-R)", "description": "The FIQ-R is a 21-item self-report questionnaire assessing the overall impact of fibromyalgia over the past 7 days. It has three domains: function (9 items), overall impact (2 items), and symptoms (10 items). The total score ranges from 0 to 100. Higher scores indicate a greater impact of the disease on daily life. The Turkish validated version will be used.", "timeFrame": "Baseline and 8 weeks" }, { "measure": "Pittsburgh Sleep Quality Index (PSQI)", "description": "The PSQI assesses sleep quality and sleep disturbances over the past month. Seven components (subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbances, use of sleep medication, daytime dysfunction) are each scored from 0 to 3. The global score ranges from 0 to 21. Higher scores indicate poorer sleep quality (a global score above 5 indicates poor sleep).", "timeFrame": "Baseline and 8 weeks" }, { "measure": "State-Trait Anxiety Inventory (STAI)", "description": "The STAI consists of 40 items rated on a 4-point scale (1-4): 20 items assess state anxiety (how the person feels at the moment) and 20 items assess trait anxiety (how the person generally feels). After reverse-scoring the relevant items, each subscale score ranges from 20 to 80. Higher scores indicate higher anxiety. The Turkish validated version will be used.", "timeFrame": "Baseline and 8 weeks" } ] }, "eligibility": { "eligibilityCriteria": "Inclusion Criteria:\n\n* Diagnosis of fibromyalgia according to the 2016 American College of Rheumatology (ACR) criteria, made by a physician\n* Female, aged 18-65 years\n* Symptomatic for at least 3 months\n* Pain intensity of 4 or higher on the Numeric Rating Scale (NRS ≥ 4; moderate to severe pain)\n* Able to read and write and understand Turkish\n* Willing to participate in the study (voluntary informed consent)\n\nExclusion Criteria:\n\n* Inflammatory rheumatologic disease (e.g., rheumatoid arthritis, systemic lupus erythematosus)\n* Active cardiac arrhythmia or implanted pacemaker\n* History of vagus nerve damage or vagotomy\n* Uncontrolled psychiatric disorder\n* Pregnancy or breastfeeding\n* Manual therapy or electrotherapy treatment within the last 3 months", "healthyVolunteers": false, "sex": "FEMALE", "genderBased": true, "genderDescription": "Only female participants are eligible, as the study investigates women diagnosed with fibromyalgia (ACR 2016 criteria).", "minimumAge": "18 Years", "maximumAge": "65 Years", "stdAges": [ "ADULT", "OLDER_ADULT" ] }, "countries": [ "Turkey (Türkiye)" ], "has_results": false }, { "id": "NCT07904559", "title": "Comparing Instrument-Assisted Soft Tissue Mobilization and Muscle Energy Technique for Myofascial Pain Syndrome in Women", "status": { "statusVerifiedDate": "2026-10", "overallStatus": "ACTIVE_NOT_RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2026-10-15", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2026-12", "type": "ESTIMATED" }, "completionDateStruct": { "date": "2026-12", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2026-10-22", "studyFirstSubmitQcDate": "2026-10-22", "studyFirstPostDateStruct": { "date": "2026-10-29", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-10-22", "lastUpdatePostDateStruct": { "date": "2026-10-29", "type": "ACTUAL" } }, "design": { "studyType": "INTERVENTIONAL", "phases": [ "NA" ], "designInfo": { "allocation": "RANDOMIZED", "interventionModel": "PARALLEL", "primaryPurpose": "TREATMENT", "maskingInfo": { "masking": "SINGLE", "whoMasked": [ "OUTCOMES_ASSESSOR" ] } }, "enrollmentInfo": { "count": 60, "type": "ACTUAL" } }, "summary": { "briefSummary": "This study compares Instrument-Assisted Soft Tissue Mobilization (IASTM) and Muscle Energy Technique (MET) in female patients with myofascial pain syndrome. The study aims to evaluate the effects of both techniques on pain and related clinical outcomes to determine their effectiveness in managing the condition." }, "outcomes": { "primaryOutcomes": [ { "measure": "Pain Intensity Measured by the Numeric Pain Rating Scale (NPRS)", "description": "Pain intensity will be assessed using the Numeric Pain Rating Scale (NPRS), an 11-point scale ranging from 0 (no pain) to 10 (worst imaginable pain). Scores will be recorded before and after the intervention to evaluate changes in pain intensity.", "timeFrame": "Baseline (before intervention) to immediately after completion of the intervention period." } ] }, "eligibility": { "eligibilityCriteria": "Inclusion Criteria:\n\n* Male and female patients aged 18-35 years.\n\nPatients diagnosed with myofascial pain syndrome.\n\nPatients experiencing localized muscle pain and tenderness.\n\nPatients willing to participate in the study and provide informed consent.\n\nPatients able to follow the treatment protocol and complete the required assessments.\n\nExclusion Criteria:\n\n* Patients with recent trauma or acute musculoskeletal injury.\n\nPatients with fractures or recent surgery in the affected area.\n\nPatients with neurological disorders affecting the study area.\n\nPatients with contraindications to Instrument-Assisted Soft Tissue Mobilization (IASTM) or Muscle Energy Technique (MET).\n\nPatients unwilling to participate or unable to complete the study protocol.", "healthyVolunteers": false, "sex": "FEMALE", "genderBased": true, "minimumAge": "18 Years", "maximumAge": "35 Years", "stdAges": [ "ADULT" ] }, "countries": [ "Pakistan" ], "has_results": false } ] } }, "web_checks": [ { "url": "https://www.isrctn.com/api/query/format/who?q=fibromyalgia&limit=100", "http_status": 200, "resolved_url": "https://www.isrctn.com/api/query/format/who?q=fibromyalgia&limit=100", "characters": 964051, "bot_or_generic_page": false }, { "url": "https://www.clinicaltrialsregister.eu/ctr-search/search?query=fibromyalgia", "http_status": 200, "resolved_url": "https://www.clinicaltrialsregister.eu/ctr-search/search?query=fibromyalgia", "characters": 81338, "bot_or_generic_page": false }, { "url": "https://www.clinicaltrialsregister.eu/ctr-search/trial/2022-001523-32/GB", "http_status": 200, "resolved_url": "https://www.clinicaltrialsregister.eu/ctr-search/trial/2022-001523-32/GB", "characters": 17848, "bot_or_generic_page": false }, { "url": "https://trialsearch.who.int/?query=fibromyalgia", "http_status": 200, "resolved_url": "https://trialsearch.who.int/?query=fibromyalgia", "characters": 64742, "bot_or_generic_page": false }, { "url": "https://www.fmauk.org/", "http_status": 200, "resolved_url": "https://www.fmauk.org/", "characters": 5167, "bot_or_generic_page": false }, { "url": "https://www.fmaware.org/", "http_status": 200, "resolved_url": "https://www.fmaware.org/", "characters": 186697, "bot_or_generic_page": false }, { "url": "https://fmcpaware.org/", "error": "HTTP Error 403: Forbidden" }, { "url": "https://enfa-europe.eu/", "http_status": 200, "resolved_url": "https://enfa-europe.eu/", "characters": 66634, "bot_or_generic_page": false }, { "url": "https://www.nice.org.uk/guidance/ng193", "http_status": 200, "resolved_url": "https://www.nice.org.uk/guidance/ng193", "characters": 21151, "bot_or_generic_page": false }, { "url": "https://www.ensaiosclinicos.gov.br/rg/RBR-6prps8g", "http_status": 200, "resolved_url": "https://ensaiosclinicos.gov.br/rg/RBR-6prps8g", "characters": 116916, "bot_or_generic_page": false }, { "name": "isrctn_internal", "url": "https://www.isrctn.com/api/query/format/internal?q=fibromyalgia&limit=1000", "http_status": null, "characters": 27 }, { "name": "nfa_news", "url": "https://www.fmaware.org/fibromyalgia-news/", "http_status": 200, "characters": 128400 }, { "name": "enfa_news", "url": "https://enfa-europe.eu/news/", "http_status": 200, "characters": 79948 }, { "name": "mdpi_bp", "url": "https://www.mdpi.com/2308-3425/13/10/474", "http_status": null, "characters": 25 }, { "name": "doi_pregnancy", "url": "https://doi.org/10.61622/rbgo/2026rbgo49", "http_status": 200, "characters": 971 }, { "name": "eu_page_2", "url": "https://www.clinicaltrialsregister.eu/ctr-search/search?query=fibromyalgia&page=2", "http_status": 200, "characters": 76332 }, { "name": "eu_page_3", "url": "https://www.clinicaltrialsregister.eu/ctr-search/search?query=fibromyalgia&page=3", "http_status": 200, "characters": 74553 }, { "name": "eu_page_4", "url": "https://www.clinicaltrialsregister.eu/ctr-search/search?query=fibromyalgia&page=4", "http_status": 200, "characters": 61318 }, { "url": "https://www.eular.org/recommendations-management", "result": "Retrieved live via web tool; current recommendations catalogue inspected; no new FM-specific replacement identified." }, { "url": "https://register.awmf.org/de/leitlinien/detail/145-004", "result": "BotStopper access denied; current revision status not verifiable. Search listings served expired 2017 PDFs, not a current update." }, { "url": "https://www.bmj.com/rapid-recommendations", "result": "Search-result page content inspected; no FM-specific recommendation listed. 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