{ "condition": "depression", "date": "2026-10-29", "author": "Claude (Opus 5.5)", "window": { "from": "2026-08-28", "to": "2026-10-29", "field": "publication date; plus Entrez date 2026-10-23 to 2026-10-29" }, "compared_with_prior_manifests": [ "literature/sweeps/2026-10-15.json", "literature/sweeps/2026-10-22.json" ], "dedupe_rule": "PMIDs present in either prior manifest or already cited by PMID anywhere in conditions/depression/*.md were excluded from triage", "window_unique_pubmed_ids": 965, "new_pubmed_ids_triaged": [ "28520380", "28613681", "30725910", "30855854", "31747213", "32644424", "39564315", "39964582", "41432737", "42105084", "42201893", "42390535", "42417173", "42903202", "42904347", "42904467", "42904492", "42904642", "42905246", "42905247", "42905249", "42905661", "42905697", "42906286", "42906704", "42906705", "42906709", "42907235", "42908300", "42908938", "42908990", "42911097", "42911781", "42912777", "42912821", "42913960", "42914487", "42914690", "42918350", 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"diagnosis", "cochrane": false, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (diagnos* OR heterogeneity OR phenotype* OR screening OR \"mixed features\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication])", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"diagnos*\"[All Fields] OR (\"heterogeneic\"[All Fields] OR \"heterogeneities\"[All Fields] OR \"heterogeneity\"[All Fields] OR \"heterogeneous\"[All Fields] OR \"heterogeneously\"[All Fields] OR \"heterogenic\"[All Fields] OR \"heterogenicity\"[All Fields] OR \"heterogenities\"[All Fields] OR \"heterogenity\"[All Fields] OR \"heterogenization\"[All Fields] OR \"heterogenized\"[All Fields] OR \"heterogenizing\"[All Fields] OR \"heterogenous\"[All Fields] OR \"heterogenously\"[All Fields]) OR \"phenotype*\"[All 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(\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR \"global burden\"[All Fields] OR \"treatment gap\"[All Fields] OR (\"registries\"[MeSH Terms] OR \"registries\"[All Fields] OR \"registry\"[All Fields] OR \"registry s\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]", "count": 0, "ids": [] }, { "topic": "mechanisms", "cochrane": false, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (neurobiolog* OR neuroinflamm* OR \"HPA axis\" OR BDNF OR \"neural circuit\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication])", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"neurobiolog*\"[All Fields] OR \"neuroinflamm*\"[All Fields] OR \"HPA axis\"[All Fields] OR (\"brain derived neurotrophic factor\"[Supplementary Concept] OR \"brain derived neurotrophic factor\"[All Fields] OR \"bdnf\"[All Fields] OR \"brain derived neurotrophic factor\"[MeSH Terms] OR (\"brain derived\"[All Fields] AND \"neurotrophic\"[All Fields] AND \"factor\"[All Fields])) OR \"neural circuit\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]", "count": 171, "ids": [ "42947966", "42944995", "42943623", "42939613", "42938483", "42938342", "42927174", "42926874", "42925683", "42921204", "42919365", "42908300", "42904642", "42903202", "42897264", "42895100", "42893748", "42892095", "42889292", "42887658", "42884023", "42883782", "42883713", "42874001", "42871390", "42870751", "42860592", "42858520", "42850268", "42842414", "42841964", "42840883", "42838181", "42828817", "42826818", "42826634", "42826581", "42819418", "42818885", "42817096", "42813034", "42810627", "42809944", "42807528", "42807520", "42806433", "42805955", "42805590", "42803524", "42797527", "42797287", "42794551", "42794424", "42793276", "42783499", "42778028", "42777979", "42773517", "42771937", "42771073", "42770453", "42770452", "42768143", "42767040", "42766483", "42765605", "42765387", "42764140", "42763338", "42762784", "42762770", "42762287", "42753853", "42752951", "42745799", "42745218", "42744142", "42737858", "42735276", "42734915", "42731592", "42729906", "42729560", "42728701", "42724084", "42723246", "42723086", "42721112", "42715443", "42710732", "42710718", "42710528", "42709645", "42707775", "42707762", "42707709", "42704208", "42702788", "42700763", "42696458", "42692098", "42688891", "42686088", "42686075", "42685988", "42679360", "42676104", "42671502", "42670051", "42668072", "42663293", "42630054", "42620154", "42613180", "42600677", "42580506", "42577036", "42572461", "42567088", "42543058", "42532352", "42508695", "42498564", "42494826", "42492720", "42435748", "42419634", "42417173", "42414566", "42390535", "42384049", "42349103", "42331234", "42322911", "42320286", "42307972", "42297310", "42296874", "42294641", "42263954", "42210495", "42178053", "42168587", "42155857", "42151503", "42144135", "42140323", "42129477", "42127355", "42119909", "42105580", "42092578", "42090938", "42086176", "42070700", "42055138", "42055137", "42055130", "42055128", "42050011", "42049070", "42044556", "42020763", "42020719", "41968289", "41963179", "41791639", "41581557", "41534638", "41307243", "40204235" ] }, { "topic": "mechanisms", "cochrane": true, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (neurobiolog* OR neuroinflamm* OR \"HPA axis\" OR BDNF OR \"neural circuit\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"neurobiolog*\"[All Fields] OR \"neuroinflamm*\"[All Fields] OR \"HPA axis\"[All Fields] OR (\"brain derived neurotrophic factor\"[Supplementary Concept] OR \"brain derived neurotrophic factor\"[All Fields] OR \"bdnf\"[All Fields] OR \"brain derived neurotrophic factor\"[MeSH Terms] OR (\"brain derived\"[All Fields] AND \"neurotrophic\"[All Fields] AND \"factor\"[All Fields])) OR \"neural circuit\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]", "count": 0, "ids": [] }, { "topic": "genetics", "cochrane": false, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (genetic* OR GWAS OR polygenic OR epigenetic* OR ancestry) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication])", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"genetic*\"[All Fields] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields]) OR (\"polygene\"[All Fields] OR \"polygenes\"[All Fields] OR \"polygenic\"[All Fields] OR \"polygenically\"[All Fields] OR \"polygenicity\"[All Fields]) OR \"epigenetic*\"[All Fields] OR (\"ancestries\"[All Fields] OR \"ancestry\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication]", "count": 181, "ids": [ "42947616", "42946686", "42938483", "42938361", "42938342", "42933578", "42929306", "42928693", "42928374", "42926676", "42922870", "42922641", "42911097", "42908300", "42907235", "42905697", "42901213", "42895100", "42894926", "28520380", "42892769", "42892069", "42891334", "42891141", "42890752", "42887784", "42886804", "42886211", "42884023", "42879530", "42876217", "42874001", "42872493", "42871888", "42871390", "42862091", "42861501", "42858520", "42858466", "42856559", "42853203", "42850268", "42839001", "42836998", "42835756", "42834754", "42833865", "42831370", "42830219", "42829528", "42826767", "42818443", "42818201", "42817096", "42814113", "42807520", "42807437", "42806433", "42803524", "42803521", "42803346", "42792438", "42791907", "42786261", "42785386", "42779037", "42778763", "42777979", "42773889", "42771937", "42771084", "42768143", "42767513", "42765387", "42765137", "42764573", "42760730", "42749774", "42749498", "42744145", "42742582", "42732835", "42728740", "42716055", "42715443", "42710732", "42710693", "42709645", "42706232", "42700945", "42696128", "42693300", "42688891", "42682166", "42679763", "42670435", "42669383", "42668072", "42667302", "42649423", "42649390", "42640306", "42633314", "42632223", "42630054", "42629468", "42625058", "42623125", "42620154", "42617977", "42613180", "42598999", "42595040", "42584886", "42580506", "42572938", "42569312", "42543058", "42537476", "42517234", "42485789", "42471042", "42462453", "42435748", "42425053", "42419634", "42418908", "42417173", "42377483", "42364336", "42350629", "42320979", "42320287", "42320286", "42316910", "42314449", "42307972", "42296874", "42267832", "42252042", "42250361", "42230966", "42210495", "42203964", "42201893", "42190845", "42178053", "42155857", "42144135", "42142759", "42134742", "42120555", "42119908", "42107849", "42105580", "42100925", "42098399", "42092578", "42092402", "42092400", "42055137", "42050011", "42047285", "42035806", "42035799", "42020763", "42020719", "42020718", "41968289", "41873584", "41845545", "41794061", "41791639", "41763442", "41761828", "41690355", "41605285", "41547389", "41534638", "40875158", "40204235" ] }, { "topic": "genetics", "cochrane": true, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (genetic* OR GWAS OR polygenic OR epigenetic* OR ancestry) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"genetic*\"[All Fields] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields]) OR (\"polygene\"[All Fields] OR \"polygenes\"[All Fields] OR \"polygenic\"[All Fields] OR \"polygenically\"[All Fields] OR \"polygenicity\"[All Fields]) OR \"epigenetic*\"[All Fields] OR (\"ancestries\"[All Fields] OR \"ancestry\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]", "count": 0, "ids": [] }, { "topic": "antidepressants", "cochrane": false, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (antidepressant* OR SSRI OR SNRI OR withdrawal OR discontinuation OR \"sexual dysfunction\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication])", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"antidepressant*\"[All Fields] OR (\"selective serotonin reuptake inhibitors\"[Pharmacological Action] OR \"selective serotonin reuptake inhibitors\"[Supplementary Concept] OR \"selective serotonin reuptake inhibitors\"[All Fields] OR \"ssri\"[All Fields] OR \"selective serotonin reuptake inhibitors\"[MeSH Terms] OR (\"selective\"[All Fields] AND \"serotonin\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"serotonin and noradrenaline reuptake inhibitors\"[Pharmacological Action] OR \"serotonin and noradrenaline reuptake inhibitors\"[Supplementary Concept] OR \"serotonin and noradrenaline reuptake inhibitors\"[All Fields] OR \"snri\"[All Fields] OR \"serotonin and noradrenaline reuptake inhibitors\"[MeSH Terms] OR (\"serotonin\"[All Fields] AND \"noradrenaline\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"withdraw\"[All Fields] OR \"withdrawal\"[All Fields] OR \"withdrawals\"[All Fields] OR \"withdrawing\"[All Fields] OR \"withdraws\"[All Fields]) OR (\"discontinuance\"[All Fields] OR \"discontinuances\"[All Fields] OR \"discontinuated\"[All Fields] OR \"discontinuation\"[All Fields] OR \"discontinuations\"[All Fields] OR \"discontinue\"[All Fields] OR \"discontinued\"[All Fields] OR \"discontinuer\"[All Fields] OR \"discontinuers\"[All Fields] OR \"discontinues\"[All Fields] OR \"discontinuing\"[All Fields]) OR \"sexual dysfunction\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]", "count": 252, "ids": [ "42947966", "42944995", "42943623", "42941695", "42935567", "42934094", "42933579", "42931956", "42931904", "42931733", "42928373", "42926874", "42925683", "42925651", "42925114", "42922724", "42906705", "42906286", "42905249", "42905247", "42905246", "42904642", "42904467", "42901397", "42901213", "42899015", "42896406", "42895746", "42895100", "42894926", "42894301", "28520380", "42892401", "42892100", "42890690", "42889347", "42889292", "42888351", "42887658", "42886804", "42883713", "42879530", "42877783", "42875717", "42871888", "42870348", "42869167", "42866549", "42863798", "42863557", "42861207", "42858801", "42858129", "42856566", "42850904", "42842414", "42841964", "42839386", "42838387", "42838181", "42835756", "42834741", "42832766", "42829528", "42826878", "42819418", "42818885", "42818515", "42817096", "42815037", "42814927", "42814111", "42812942", "42812643", "42812173", "42805662", "42805099", "42803521", "42801835", "42799904", "42797287", "42795930", "42795740", "42793276", "42792385", "42788073", "42786817", "42785392", "42784817", "42783499", "42778211", "42774912", "42770597", "42769822", "42769711", "42767626", "42767564", "42767040", "42766849", "42766673", "42766019", "42763552", "42762641", "42761770", "42756843", "42756839", "42753853", "42752587", "42751846", "42750362", "42750260", "42739877", "42736557", "42735274", "30725910", "28613681", "42732834", "42731592", "42729560", "42729393", "42729184", "42728072", "42727730", "42727635", "42725261", "42724084", "42722435", "42716345", "42716055", "42715443", "42715127", "42710716", "42710412", "42707709", "42705363", "42702010", "42701679", "42701110", "42700488", "42696738", "42696458", "42695158", "42692098", "42690086", "42688594", "42686996", "42684694", "42684061", "42682977", "42680855", "42680119", "42679360", "42674239", "42670957", "42668390", "42668254", "42668072", "42667302", "42665164", "42664168", "42663293", "42658027", "42642808", "42640306", "42640305", "42628206", "42621346", "42616023", "42610482", "42595101", "42595040", "42584886", "42581396", "42580506", "42572461", "42562964", "42556713", "42550483", "42532352", "42531622", "42524749", "42522066", "42518156", "42508605", "42508527", "42508525", "42494826", "42492718", "42475069", "42470859", "42462453", "42455478", "42435731", "42418124", "42414566", "42413809", "42411994", "42410139", "42384049", "42379544", "42379141", "42362819", "42361653", "42341411", "42322911", "42307972", "42302638", "42284801", "42283956", "42276172", "42264040", "42263954", "42252042", "42250361", "42248243", "42242455", "42203004", "42176815", "42176813", "42169234", "42168587", "42167696", "42151503", "42131982", "42129477", "42127355", "42119282", "42115366", "42107656", "42105579", "42103244", "42086176", "42065494", "42055130", "42050011", "42047285", "42035805", "41986746", "41963179", "41904070", "41903946", "41873584", "41817153", "41814584", "41807319", "41804951", "41691708", "41558805", "41534638", "41432737", "41111092", "40977395" ] }, { "topic": "antidepressants", "cochrane": true, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (antidepressant* OR SSRI OR SNRI OR withdrawal OR discontinuation OR \"sexual dysfunction\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"antidepressant*\"[All Fields] OR (\"selective serotonin reuptake inhibitors\"[Pharmacological Action] OR \"selective serotonin reuptake inhibitors\"[Supplementary Concept] OR \"selective serotonin reuptake inhibitors\"[All Fields] OR \"ssri\"[All Fields] OR \"selective serotonin reuptake inhibitors\"[MeSH Terms] OR (\"selective\"[All Fields] AND \"serotonin\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"serotonin and noradrenaline reuptake inhibitors\"[Pharmacological Action] OR \"serotonin and noradrenaline reuptake inhibitors\"[Supplementary Concept] OR \"serotonin and noradrenaline reuptake inhibitors\"[All Fields] OR \"snri\"[All Fields] OR \"serotonin and noradrenaline reuptake inhibitors\"[MeSH Terms] OR (\"serotonin\"[All Fields] AND \"noradrenaline\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"withdraw\"[All Fields] OR \"withdrawal\"[All Fields] OR \"withdrawals\"[All Fields] OR \"withdrawing\"[All Fields] OR \"withdraws\"[All Fields]) OR (\"discontinuance\"[All Fields] OR \"discontinuances\"[All Fields] OR \"discontinuated\"[All Fields] OR \"discontinuation\"[All Fields] OR \"discontinuations\"[All Fields] OR \"discontinue\"[All Fields] OR \"discontinued\"[All Fields] OR \"discontinuer\"[All Fields] OR \"discontinuers\"[All Fields] OR \"discontinues\"[All Fields] OR \"discontinuing\"[All Fields]) OR \"sexual dysfunction\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]", "count": 0, "ids": [] }, { "topic": "efficacy", "cochrane": false, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (\"publication bias\" OR placebo OR STAR*D OR \"clinical significance\" OR \"individual participant\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication])", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"publication bias\"[All Fields] OR (\"placeboes\"[All Fields] OR \"placebos\"[Supplementary Concept] OR \"placebos\"[All Fields] OR \"placebo\"[All Fields] OR \"placebos\"[MeSH Terms]) OR \"star*d\"[All Fields] OR \"clinical significance\"[All Fields] OR \"individual participant\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]", "count": 47, "ids": [ "42943623", "42919365", "42904467", "42904347", "42892401", "42877783", "42870348", "42863798", "42858520", "42815730", "42812942", "42802397", "42789363", "42778211", "42774912", "42766673", "42752587", "42733696", "42729393", "42721112", "42701110", "42690086", "42688558", "42684061", "42680855", "42680119", "42670051", "42610482", "42562964", "42550483", "42522066", "42494826", "42470859", "42455478", "42435731", "42414566", "42383744", "42350630", "42283956", "42252042", "42176815", "42176813", "42140323", "41963179", "41790247", "41558805", "41191045" ] }, { "topic": "efficacy", "cochrane": true, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (\"publication bias\" OR placebo OR STAR*D OR \"clinical significance\" OR \"individual participant\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"publication bias\"[All Fields] OR (\"placeboes\"[All Fields] OR \"placebos\"[Supplementary Concept] OR \"placebos\"[All Fields] OR \"placebo\"[All Fields] OR \"placebos\"[MeSH Terms]) OR \"star*d\"[All Fields] OR \"clinical significance\"[All Fields] OR \"individual participant\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]", "count": 0, "ids": [] }, { "topic": "psychotherapy", "cochrane": false, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (psychotherap* OR \"cognitive behavioral\" OR \"behavioural activation\" OR exercise OR \"task sharing\" OR \"task-shared\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication])", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"psychotherap*\"[All Fields] OR \"cognitive behavioral\"[All Fields] OR \"behavioural activation\"[All Fields] OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]) OR \"task sharing\"[All Fields] OR \"task-shared\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]", "count": 128, "ids": [ "42948034", "42940591", "42938483", "42925997", "42921031", "42906705", "42906286", "42905697", "42896406", "42895746", "42892100", "42892095", "42889347", "42886483", "42879686", "42879530", "42877783", "42872182", "42869999", "42865326", "42863798", "42863717", "42858129", "42854791", "42844936", "42843278", "42839301", "42838229", "42835728", "42834832", "42815884", "42812173", "42807040", "42805955", "42801310", "42799904", "42796411", "42795740", "42792385", "42789363", "42789054", "42785391", "42784817", "42779037", "42766019", "42756843", "42756688", "42750260", "42749161", "42736557", "42735276", "42734915", "42732835", "42732834", "42732542", "42726702", "42725261", "42724084", "42714093", "42710691", "42709645", "42700486", "42686352", "42682977", "42680855", "42679601", "42678888", "42669842", "42669383", "42664168", "42640306", "42632223", "42625058", "42612565", "42567088", "42562964", "42558024", "42550483", "42550193", "42518170", "42485789", "42475069", "42470859", "42435731", "42432162", "42425188", "42425030", "42418908", "42418124", "42413809", "42411994", "42390535", "42384049", "42383885", "42379068", "42362819", "42294641", "42284801", "42269957", "42269542", "42263954", "42248243", "42217371", "42215638", "42184575", "42169234", "42155212", "42140319", "42134745", "42131982", "42129477", "42119908", "42119282", "42107658", "42096803", "42070700", "42047285", "42014469", "42002221", "41991348", "41807319", "41791639", "41787762", "41690355", "41558805", "40830864", "40204235", "40184540" ] }, { "topic": "psychotherapy", "cochrane": true, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (psychotherap* OR \"cognitive behavioral\" OR \"behavioural activation\" OR exercise OR \"task sharing\" OR \"task-shared\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"psychotherap*\"[All Fields] OR \"cognitive behavioral\"[All Fields] OR \"behavioural activation\"[All Fields] OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]) OR \"task sharing\"[All Fields] OR \"task-shared\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]", "count": 0, "ids": [] }, { "topic": "resistance", "cochrane": false, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (\"treatment resistant\" OR \"treatment-resistant\" OR augmentation OR lithium OR sequencing) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication])", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"treatment-resistant\"[All Fields] OR \"treatment-resistant\"[All Fields] OR (\"augment\"[All Fields] OR \"augmentation\"[All Fields] OR \"augmentations\"[All Fields] OR \"augmented\"[All Fields] OR \"augmenting\"[All Fields] OR \"augments\"[All Fields]) OR (\"lithium\"[Supplementary Concept] OR \"lithium\"[All Fields] OR \"lithium\"[MeSH Terms] OR \"lithium s\"[All Fields] OR \"lithiums\"[All Fields]) OR (\"base sequence\"[MeSH Terms] OR (\"base\"[All Fields] AND \"sequence\"[All Fields]) OR \"base sequence\"[All Fields] OR \"sequence\"[All Fields] OR \"sequences\"[All Fields] OR \"sequence analysis\"[MeSH Terms] OR (\"sequence\"[All Fields] AND \"analysis\"[All Fields]) OR \"sequence analysis\"[All Fields] OR \"sequencing\"[All Fields] OR \"sequence s\"[All Fields] OR \"sequenceable\"[All Fields] OR \"sequenced\"[All Fields] OR \"sequenceing\"[All Fields] OR \"sequencer\"[All Fields] OR \"sequencers\"[All Fields] OR \"sequencies\"[All Fields] OR \"sequencings\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication]", "count": 172, "ids": [ "42946686", "42941695", "42938342", "42935567", "42934485", "42933579", "42931733", "42928693", "42925575", "42918350", "42905249", "42905247", "42905246", "42896406", "42895100", "42892401", "42892100", "42890690", "42889292", "42887658", "42879530", "42878501", "42878230", "42876217", "42870751", "42870348", "42869167", "42865326", "42864698", "42864498", "42863798", "42861501", "42858129", "42856359", "42849015", "42844676", "42844674", "42843471", "42841964", "42840696", "42831370", "42830219", "42829941", "42818885", "42818515", "42818201", "42817096", "42815730", "42814927", "42813034", "42812942", "42812173", "42807040", "42803524", "42799904", "42789054", "42788073", "42783499", "42783367", "42778763", "42771084", "42769103", "42768327", "42767513", "42767040", "42766673", "42766497", "42766019", "42765892", "42762641", "42761770", "42760730", "42756843", "42756688", "42756176", "42753254", "42751846", "42749498", "42748866", "42745306", "42745218", "42744145", "42742966", "42736349", "30855854", "42732835", "42732834", "42732542", "42729848", "42728740", "42727730", "42721112", "42711407", "42702010", "42700945", "42700487", "42699006", "42690530", "42686996", "42684694", "42684061", "42682977", "42682166", "42679763", "42679236", "42678910", "42675468", "42668390", "42663266", "42658152", "42658027", "42649423", "42649390", "42642808", "42630054", "42629468", "42625058", "42620154", "42613180", "42598999", "42580506", "42562964", "42542090", "42532352", "42531622", "42518156", "42517234", "42508605", "42502622", "42492720", "42435748", "42390535", "42383744", "42379141", "42379068", "42377483", "42364336", "42339150", "42320287", "42307972", "42302659", "42302638", "42267832", "42248243", "42240040", "42230966", "42219697", "42210495", "42203964", "42144137", "42140321", "42127355", "42119282", "42107849", "42100925", "42065494", "42050011", "42035806", "42035799", "42020763", "42020719", "42020718", "41963179", "41904070", "41873584", "41814584", "41763442", "41761828", "41605285", "41558805", "41111092", "40875158" ] }, { "topic": "resistance", "cochrane": true, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (\"treatment resistant\" OR \"treatment-resistant\" OR augmentation OR lithium OR sequencing) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"treatment-resistant\"[All Fields] OR \"treatment-resistant\"[All Fields] OR (\"augment\"[All Fields] OR \"augmentation\"[All Fields] OR \"augmentations\"[All Fields] OR \"augmented\"[All Fields] OR \"augmenting\"[All Fields] OR \"augments\"[All Fields]) OR (\"lithium\"[Supplementary Concept] OR \"lithium\"[All Fields] OR \"lithium\"[MeSH Terms] OR \"lithium s\"[All Fields] OR \"lithiums\"[All Fields]) OR (\"base sequence\"[MeSH Terms] OR (\"base\"[All Fields] AND \"sequence\"[All Fields]) OR \"base sequence\"[All Fields] OR \"sequence\"[All Fields] OR \"sequences\"[All Fields] OR \"sequence analysis\"[MeSH Terms] OR (\"sequence\"[All Fields] AND \"analysis\"[All Fields]) OR \"sequence analysis\"[All Fields] OR \"sequencing\"[All Fields] OR \"sequence s\"[All Fields] OR \"sequenceable\"[All Fields] OR \"sequenced\"[All Fields] OR \"sequenceing\"[All Fields] OR \"sequencer\"[All Fields] OR \"sequencers\"[All Fields] OR \"sequencies\"[All Fields] OR \"sequencings\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]", "count": 0, "ids": [] }, { "topic": "glutamatergic", "cochrane": false, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (ketamine OR esketamine OR dextromethorphan OR hydroxynorketamine OR zelquistinel) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication])", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"ketamin\"[All Fields] OR \"ketamine\"[Supplementary Concept] OR \"ketamine\"[All Fields] OR \"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields] OR \"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields] OR \"ketamine\"[MeSH Terms] OR \"ketamine s\"[All Fields] OR \"ketamines\"[All Fields] OR (\"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields]) OR (\"dextromethorphan\"[Supplementary Concept] OR \"dextromethorphan\"[All Fields] OR \"dextromethorphan\"[MeSH Terms] OR \"dextromethorphane\"[All Fields]) OR \"hydroxynorketamine\"[All Fields] OR \"zelquistinel\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]", "count": 56, "ids": [ "42933579", "42931733", "42904467", "42896406", "42894304", "42894301", "42894300", "42889292", "42879530", "42877783", "42869167", "42865326", "42863798", "42858129", "42838387", "42835728", "42812942", "42803524", "42767564", "42767040", "42762641", "42756688", "42755741", "42748866", "42735276", "42721112", "42702010", "42692098", "42684694", "42682977", "42663266", "42616023", "42610482", "42572461", "42562964", "42556713", "42531622", "42522066", "42518156", "42508525", "42384049", "42377483", "42302638", "42240040", "42217548", "42151503", "42140321", "42103244", "42065494", "41873584", "41844563", "41814584", "41582323", "41191045", "41111092", "39964582" ] }, { "topic": "glutamatergic", "cochrane": true, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (ketamine OR esketamine OR dextromethorphan OR hydroxynorketamine OR zelquistinel) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"ketamin\"[All Fields] OR \"ketamine\"[Supplementary Concept] OR \"ketamine\"[All Fields] OR \"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields] OR \"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields] OR \"ketamine\"[MeSH Terms] OR \"ketamine s\"[All Fields] OR \"ketamines\"[All Fields] OR (\"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields]) OR (\"dextromethorphan\"[Supplementary Concept] OR \"dextromethorphan\"[All Fields] OR \"dextromethorphan\"[MeSH Terms] OR \"dextromethorphane\"[All Fields]) OR \"hydroxynorketamine\"[All Fields] OR \"zelquistinel\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]", "count": 0, "ids": [] }, { "topic": "neuromodulation", "cochrane": false, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (electroconvulsive OR \"transcranial magnetic\" OR iTBS OR tDCS OR \"vagus nerve\" OR \"deep brain stimulation\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication])", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"electroconvulsant\"[All Fields] OR \"electroconvulsion\"[All Fields] OR \"electroconvulsions\"[All Fields] OR \"electroconvulsive\"[All Fields] OR \"transcranial magnetic\"[All Fields] OR \"iTBS\"[All Fields] OR (\"transcranial direct current stimulation\"[MeSH Terms] OR (\"transcranial\"[All Fields] AND \"direct\"[All Fields] AND \"current\"[All Fields] AND \"stimulation\"[All Fields]) OR \"transcranial direct current stimulation\"[All Fields] OR \"tdcs\"[All Fields]) OR \"vagus nerve\"[All Fields] OR \"deep brain stimulation\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]", "count": 110, "ids": [ "42951036", "42948034", "42935567", "42934485", "42927380", "42926624", "42924478", "42922724", "42914690", "42895746", "42892100", "42890690", "42880443", "42879997", "42878501", "42878230", "42877696", "42870348", "42864698", "42863719", "42863253", "42860592", "42858129", "42855128", "42844676", "42844674", "42843471", "42841964", "42839296", "42838181", "42830939", "42829057", "42829029", "42818515", "42810830", "42801310", "42799904", "42789363", "42789054", "42787626", "42785385", "42785233", "42783367", "42769949", "42766673", "42766019", "42762784", "42753347", "42745306", "42745218", "42735276", "30855854", "42731592", "42727730", "42721517", "42721112", "42700487", "42700486", "42699697", "42696738", "42687377", "42686996", "42679601", "42679236", "42676877", "42675468", "42674239", "42668924", "42658152", "42642808", "42628206", "42595040", "42581396", "42524749", "42518170", "42508605", "42502622", "42492720", "42475069", "42398293", "42390535", "42384049", "42383744", "42341411", "42339150", "42335495", "42302659", "42284801", "42272332", "42265226", "42252042", "42223086", "42219697", "42155351", "42127355", "42115366", "42107658", "42090938", "42086176", "42035805", "41986746", "41862185", "41814584", "41807319", "41690355", "40228165", "40184540", "40168143", "40132108", "39964582" ] }, { "topic": "neuromodulation", "cochrane": true, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (electroconvulsive OR \"transcranial magnetic\" OR iTBS OR tDCS OR \"vagus nerve\" OR \"deep brain stimulation\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"electroconvulsant\"[All Fields] OR \"electroconvulsion\"[All Fields] OR \"electroconvulsions\"[All Fields] OR \"electroconvulsive\"[All Fields] OR \"transcranial magnetic\"[All Fields] OR \"iTBS\"[All Fields] OR (\"transcranial direct current stimulation\"[MeSH Terms] OR (\"transcranial\"[All Fields] AND \"direct\"[All Fields] AND \"current\"[All Fields] AND \"stimulation\"[All Fields]) OR \"transcranial direct current stimulation\"[All Fields] OR \"tdcs\"[All Fields]) OR \"vagus nerve\"[All Fields] OR \"deep brain stimulation\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]", "count": 0, "ids": [] }, { "topic": "novel", "cochrane": false, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (psilocybin OR psychedelic* OR neurosteroid* OR zuranolone OR brexanolone OR CYB003 OR \"GM-2505\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication])", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"psilocybin\"[Supplementary Concept] OR \"psilocybin\"[All Fields] OR \"psilocybin\"[MeSH Terms] OR \"psilocybine\"[All Fields] OR \"psilocybin s\"[All Fields] OR \"psychedelic*\"[All Fields] OR \"neurosteroid*\"[All Fields] OR (\"zuranolone\"[Supplementary Concept] OR \"zuranolone\"[All Fields]) OR (\"brexanolone\"[Supplementary Concept] OR \"brexanolone\"[All Fields]) OR \"GM-2505\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]", "count": 26, "ids": [ "42931904", "42931733", "42922724", "42906286", "42896406", "42869167", "42865326", "42835728", "42834832", "42809944", "42750260", "42735276", "42732542", "42663266", "42658027", "42580506", "42562964", "42531622", "42414566", "42379141", "42320287", "42302638", "42252042", "42215638", "41963179", "41191045" ] }, { "topic": "novel", "cochrane": true, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (psilocybin OR psychedelic* OR neurosteroid* OR zuranolone OR brexanolone OR CYB003 OR \"GM-2505\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"psilocybin\"[Supplementary Concept] OR \"psilocybin\"[All Fields] OR \"psilocybin\"[MeSH Terms] OR \"psilocybine\"[All Fields] OR \"psilocybin s\"[All Fields] OR \"psychedelic*\"[All Fields] OR \"neurosteroid*\"[All Fields] OR (\"zuranolone\"[Supplementary Concept] OR \"zuranolone\"[All Fields]) OR (\"brexanolone\"[Supplementary Concept] OR \"brexanolone\"[All Fields]) OR \"GM-2505\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]", "count": 0, "ids": [] }, { "topic": "prediction", "cochrane": false, "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (biomarker* OR pharmacogen* OR prediction OR \"machine learning\" OR \"digital phenotyping\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/29\"[Date - Publication])", "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"biomarker*\"[All Fields] OR \"pharmacogen*\"[All Fields] OR (\"predict\"[All Fields] OR \"predictabilities\"[All Fields] OR \"predictability\"[All Fields] OR \"predictable\"[All Fields] OR \"predictably\"[All Fields] OR \"predicted\"[All Fields] OR \"predicting\"[All Fields] OR \"prediction\"[All Fields] OR \"predictions\"[All Fields] OR \"predictive\"[All Fields] OR \"predictively\"[All Fields] OR \"predictiveness\"[All Fields] OR \"predictives\"[All Fields] OR \"predictivities\"[All Fields] OR \"predictivity\"[All Fields] OR \"predicts\"[All Fields]) OR \"machine learning\"[All Fields] OR \"digital phenotyping\"[All Fields]) AND 2026/08/28:2026/10/29[Date - Publication]", "count": 323, "ids": [ "42951037", "42951036", "42947616", "42946686", "42940015", "42939613", "42938483", "42938361", "42934094", "42929306", "42928939", "42928662", "42928374", "42927174", "42926874", "42924883", "42922724", "42922641", "42921204", "42921031", "42920722", "42918858", "42918425", "42918350", "42913960", "42911097", "42907235", "42906709", "42905697", "42904642", "42904492", "42903202", "42901970", "42901213", "42897683", "42896406", "42895100", "42894926", "28520380", "42892769", "42892100", "42892069", "42890752", "42889194", "42887784", "42887530", "42884380", "42884023", "42883782", "42883713", "42878501", "42877696", "42876953", "42875717", "42874811", "42873387", "42872493", "42872182", "42871667", "42871390", "42870751", "42869999", "42866549", "42863253", "42861501", "42861312", "42860592", "42858801", "42858129", "42856566", "42856559", "42855128", "42851958", "42846268", "42844674", "42843469", "42843279", "42841964", "42840883", "42840696", "42839301", "42838181", "42834754", "42833865", "42833406", "42832644", "42831370", "42830939", "42829528", "42829057", "42826878", "42826821", "42826818", "42826767", "42826634", "42826067", "42822715", "42822187", "42820260", "42818201", "42815884", "42815731", "42813034", "42812173", "42811409", "42810830", "42810627", "42806848", "42806433", "42805955", "42805099", "42803524", "42801835", "42799620", "42797527", "42796411", "42794622", "42794551", "42794424", "42792438", "42792385", "42791907", "42788145", "42787777", "42787408", "42785393", "42785392", "42785391", "42785390", "42783499", "42780703", "42777933", "42775302", 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OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"suicid*\"[All Fields] OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading]) OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]) OR \"adverse effect\"[All Fields] OR (\"mania\"[MeSH Terms] OR \"mania\"[All Fields] OR \"manias\"[All Fields]) OR (\"drug overdose\"[MeSH Terms] OR (\"drug\"[All Fields] AND \"overdose\"[All Fields]) OR \"drug overdose\"[All Fields] OR \"overdose\"[All Fields] OR \"overdoses\"[All Fields] OR \"overdosed\"[All Fields] OR \"overdosing\"[All Fields])) AND 2026/08/28:2026/10/29[Date - Publication]", "count": 242, "ids": [ "42951038", "42951036", "42947773", "42945872", "42938483", "42938342", "42933579", "42931733", "42929087", "42928374", "42926695", "42926624", "42926317", "42925114", "42924883", "42922641", "42912821", "42912777", "42911781", "42908300", "42906705", 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TITLE_ABS:\"unipolar depression\") AND (epidemiology OR prevalence OR incidence OR \"global burden\" OR \"treatment gap\" OR registry) AND FIRST_PDATE:[2026-08-28 TO 2026-10-29]", "http": 200, "hitCount": 230 }, { "topic": "mechanisms", "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (neurobiolog* OR neuroinflamm* OR \"HPA axis\" OR BDNF OR \"neural circuit\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-29]", "http": 200, "hitCount": 201 }, { "topic": "genetics", "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (genetic* OR GWAS OR polygenic OR epigenetic* OR ancestry) AND FIRST_PDATE:[2026-08-28 TO 2026-10-29]", "http": 200, "hitCount": 197 }, { "topic": "antidepressants", "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (antidepressant* OR SSRI OR SNRI OR withdrawal OR discontinuation 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