{
  "condition": "depression",
  "date": "2026-10-22",
  "author": "Grok",
  "window": {
    "from": "2026-08-28",
    "to": "2026-10-22",
    "field": "publication date"
  },
  "compared_with_prior_manifest": "literature/sweeps/2026-10-15.json",
  "prior_pubmed_id_count": 795,
  "window_unique_pubmed_ids": 856,
  "new_pubmed_ids_not_in_prior_manifest": [
    "42901970",
    "42901397",
    "42901213",
    "42899015",
    "42898229",
    "42897683",
    "42897264",
    "42896406",
    "42896217",
    "42896175",
    "42895746",
    "42895100",
    "42894926",
    "42894304",
    "42894301",
    "42894300",
    "42893748",
    "42892769",
    "42892401",
    "42892100",
    "42892099",
    "42892095",
    "42892069",
    "42891334",
    "42891241",
    "42891141",
    "42890752",
    "42890690",
    "42889347",
    "42889292",
    "42889194",
    "42888351",
    "42887784",
    "42887658",
    "42887530",
    "42887092",
    "42886804",
    "42886483",
    "42886211",
    "42885693",
    "42884380",
    "42884023",
    "42883782",
    "42883713",
    "42880603",
    "42880597",
    "42880443",
    "42880279",
    "42879997",
    "42879916",
    "42879686",
    "42879530",
    "42878501",
    "42878230",
    "42877783",
    "42877696",
    "42877540",
    "42876953",
    "42876217",
    "42875717",
    "42629468",
    "42617977",
    "42575363",
    "42524749",
    "40977395",
    "40830864",
    "28520380"
  ],
  "edat_only_ids": [
    "42902279",
    "42902270",
    "42901399",
    "42898691",
    "42897167",
    "42896686",
    "42894373",
    "42893994",
    "42892400",
    "42892399",
    "42885695"
  ],
  "cdsr_2026_ids_not_in_prior_manifest": [
    "42863850",
    "42644645",
    "42339755",
    "42206608",
    "42138335",
    "42117563",
    "42011808",
    "41700575",
    "41636687",
    "41542871"
  ],
  "pubmed": [
    {
      "topic": "diagnosis",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (diagnos* OR heterogeneity OR phenotype* OR screening OR \"mixed features\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"diagnos*\"[All Fields] OR (\"heterogeneic\"[All Fields] OR \"heterogeneities\"[All Fields] OR \"heterogeneity\"[All Fields] OR \"heterogeneous\"[All Fields] OR \"heterogeneously\"[All Fields] OR \"heterogenic\"[All Fields] OR \"heterogenicity\"[All Fields] OR \"heterogenities\"[All Fields] OR \"heterogenity\"[All Fields] OR \"heterogenization\"[All Fields] OR \"heterogenized\"[All Fields] OR \"heterogenizing\"[All Fields] OR \"heterogenous\"[All Fields] OR \"heterogenously\"[All Fields]) OR \"phenotype*\"[All Fields] OR (\"diagnosis\"[MeSH Subheading] OR \"diagnosis\"[All Fields] OR \"screening\"[All Fields] OR \"mass screening\"[MeSH Terms] OR (\"mass\"[All Fields] AND \"screening\"[All Fields]) OR \"mass screening\"[All Fields] OR \"early detection of cancer\"[MeSH Terms] OR (\"early\"[All Fields] AND \"detection\"[All Fields] AND \"cancer\"[All Fields]) OR \"early detection of cancer\"[All Fields] OR \"screen\"[All Fields] OR \"screenings\"[All Fields] OR \"screened\"[All Fields] OR \"screens\"[All Fields]) OR \"mixed features\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 514,
      "ids": [
        "42901970",
        "42901397",
        "42898229",
        "42897264",
        "42896175",
        "42895100",
        "42894926",
        "28520380",
        "42892769",
        "42892099",
        "42892069",
        "42891334",
        "42891241",
        "42891141",
        "42890752",
        "42889194",
        "42888351",
        "42887784",
        "42887658",
        "42887530",
        "42885693",
        "42884380",
        "42884023",
        "42883782",
        "42883713",
        "42880603",
        "42880597",
        "42879997",
        "42879916",
        "42879686",
        "42879530",
        "42877696",
        "42877540",
        "42875717",
        "42873880",
        "42873387",
        "42872768",
        "42872493",
        "42872469",
        "42872182",
        "42871667",
        "42871390",
        "42869999",
        "42869167",
        "42867189",
        "42866549",
        "42866493",
        "42866044",
        "42863800",
        "42863798",
        "42863557",
        "42863253",
        "42862091",
        "42861501",
        "42861312",
        "42861207",
        "42858801",
        "42858466",
        "42858455",
        "42858131",
        "42858129",
        "42856559",
        "42856359",
        "42855248",
        "42850904",
        "42850268",
        "42849853",
        "42849015",
        "42848743",
        "42846268",
        "42844936",
        "42843469",
        "42843279",
        "42843278",
        "42841964",
        "42841689",
        "42840913",
        "42840883",
        "42839301",
        "42839296",
        "42839001",
        "42838387",
        "42838229",
        "42838181",
        "42837291",
        "42837085",
        "42835756",
        "42835728",
        "42834754",
        "42833865",
        "42833406",
        "42832644",
        "42831370",
        "42829941",
        "42829057",
        "42829056",
        "42828817",
        "42828816",
        "42828479",
        "42826818",
        "42826767",
        "42826634",
        "42826067",
        "42822715",
        "42822232",
        "42822187",
        "42820260",
        "42819418",
        "42818443",
        "42818201",
        "42815877",
        "42815731",
        "42815730",
        "42815037",
        "42814927",
        "42814113",
        "42813267",
        "42813034",
        "42812643",
        "42812173",
        "42811409",
        "42811249",
        "42810627",
        "42809578",
        "42807528",
        "42807520",
        "42806848",
        "42806433",
        "42806365",
        "42805955",
        "42805662",
        "42805590",
        "42804205",
        "42804067",
        "42803524",
        "42803346",
        "42802390",
        "42799620",
        "42799588",
        "42799462",
        "42798114",
        "42796411",
        "42796071",
        "42794622",
        "42794424",
        "42792438",
        "42788073",
        "42787626",
        "42786817",
        "42786261",
        "42785392",
        "42785391",
        "42785390",
        "42785386",
        "42785233",
        "42784817",
        "42783499",
        "42783367",
        "42780377",
        "42779163",
        "42779162",
        "42779037",
        "42778763",
        "42778211",
        "42778028",
        "42777979",
        "42777239",
        "42775302",
        "42774912",
        "42773889",
        "42773517",
        "42771937",
        "42771073",
        "42770597",
        "42770453",
        "42769949",
        "42769103",
        "42768327",
        "42768143",
        "42767513",
        "42767042",
        "42767040",
        "42766849",
        "42765892",
        "42765861",
        "42765605",
        "42765387",
        "42765137",
        "42763338",
        "42762770",
        "42762626",
        "42761770",
        "42761292",
        "42760730",
        "42760705",
        "42758600",
        "42758324",
        "42757108",
        "42756839",
        "42756688",
        "42756176",
        "42756128",
        "42755741",
        "42754771",
        "42753347",
        "42753254",
        "42752951",
        "42752290",
        "42752169",
        "42751846",
        "42751051",
        "42750362",
        "42749683",
        "42749161",
        "42748866",
        "42748805",
        "42746369",
        "42744142",
        "42739877",
        "42737920",
        "42737858",
        "42736557",
        "42736349",
        "42735276",
        "42734915",
        "42733696",
        "42732835",
        "42732542",
        "42731320",
        "42729848",
        "42729393",
        "42728740",
        "42728072",
        "42727204",
        "42726936",
        "42726636",
        "42725756",
        "42723086",
        "42722619",
        "42722301",
        "42721198",
        "42721164",
        "42717325",
        "42716347",
        "42716345",
        "42716277",
        "42713675",
        "42711407",
        "32644424",
        "42710732",
        "42710718",
        "42710716",
        "42710693",
        "42710643",
        "42710528",
        "42710021",
        "42709166",
        "42707775",
        "42706232",
        "42705400",
        "42704775",
        "42704208",
        "42702788",
        "42701687",
        "42701679",
        "42700945",
        "42700777",
        "42700488",
        "42700486",
        "42699006",
        "42698280",
        "42698177",
        "42696738",
        "42696458",
        "42696128",
        "42695028",
        "42692098",
        "42688891",
        "42688558",
        "42686352",
        "42686088",
        "42686075",
        "42686074",
        "42685988",
        "42684694",
        "42684674",
        "42682166",
        "42681589",
        "42680855",
        "42680119",
        "42679763",
        "42679360",
        "42676877",
        "42676104",
        "42675468",
        "42675332",
        "42674299",
        "42674239",
        "42670957",
        "42670435",
        "42670051",
        "42669842",
        "42669383",
        "42668924",
        "42668072",
        "42667366",
        "42665164",
        "42663608",
        "42649423",
        "42642808",
        "42640306",
        "42640305",
        "42636957",
        "42635055",
        "42633856",
        "42633314",
        "42625058",
        "42624134",
        "42623125",
        "42621346",
        "42620154",
        "42617977",
        "42612565",
        "42610482",
        "42610207",
        "42607586",
        "42607410",
        "42600677",
        "42598999",
        "42598032",
        "42595101",
        "42595040",
        "42594760",
        "42581396",
        "42580506",
        "42575363",
        "42572630",
        "42571148",
        "42569312",
        "42567088",
        "42562964",
        "42561530",
        "42558024",
        "42550193",
        "42546834",
        "42543058",
        "42537476",
        "42533130",
        "42532398",
        "42528357",
        "42528344",
        "42524749",
        "42522354",
        "42522066",
        "42517234",
        "42508605",
        "42498564",
        "42498428",
        "42494826",
        "42492720",
        "42492718",
        "42485972",
        "42475069",
        "42474069",
        "42471518",
        "42471042",
        "42470859",
        "42464919",
        "42462453",
        "42462416",
        "42455478",
        "42435731",
        "42432162",
        "42425188",
        "42425053",
        "42425030",
        "42419634",
        "42419463",
        "42418908",
        "42413809",
        "42410139",
        "42399489",
        "42398293",
        "42384049",
        "42383885",
        "42383744",
        "42377414",
        "42370887",
        "42364336",
        "42362819",
        "42358003",
        "42350630",
        "42350629",
        "42349103",
        "42337428",
        "42331234",
        "42330683",
        "42320979",
        "42320286",
        "42314449",
        "42314447",
        "42310163",
        "42307972",
        "42302888",
        "42302638",
        "42301395",
        "42298346",
        "42296874",
        "42284804",
        "42284801",
        "42276172",
        "42269542",
        "42265226",
        "42264040",
        "42263954",
        "42252042",
        "42250361",
        "42250253",
        "42248243",
        "42230966",
        "42223086",
        "42219697",
        "42217371",
        "42215638",
        "42211077",
        "42203964",
        "42203004",
        "42190845",
        "42177868",
        "42176815",
        "42176813",
        "42173043",
        "42169234",
        "42168587",
        "42167697",
        "42167696",
        "42167549",
        "42155857",
        "42155212",
        "42151503",
        "42144137",
        "42144135",
        "42142759",
        "42140323",
        "42140321",
        "42140319",
        "42134745",
        "42134744",
        "42134743",
        "42134742",
        "42134004",
        "42131982",
        "42129477",
        "42127355",
        "42120555",
        "42119909",
        "42119282",
        "42119185",
        "42115366",
        "42107653",
        "42106071",
        "42105580",
        "42105579",
        "42103239",
        "42092402",
        "42090938",
        "42087765",
        "42084387",
        "42081006",
        "42070700",
        "42070122",
        "42065494",
        "42055138",
        "42055130",
        "42055128",
        "42053632",
        "42050011",
        "42049070",
        "42049068",
        "42044556",
        "42035799",
        "42035454",
        "42031014",
        "42020719",
        "42014469",
        "42013686",
        "42002221",
        "41968289",
        "41947665",
        "41921889",
        "41904070",
        "41903946",
        "41880255",
        "41845545",
        "41807319",
        "41794061",
        "41791639",
        "41790247",
        "41762174",
        "41690355",
        "41582323",
        "41581557",
        "41500406",
        "41434748",
        "41429013",
        "41319841",
        "41275966",
        "41247288",
        "40996024",
        "40875158",
        "40830864",
        "40204235",
        "40168143",
        "39564315"
      ],
      "http": 200
    },
    {
      "topic": "diagnosis",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (diagnos* OR heterogeneity OR phenotype* OR screening OR \"mixed features\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"diagnos*\"[All Fields] OR (\"heterogeneic\"[All Fields] OR \"heterogeneities\"[All Fields] OR \"heterogeneity\"[All Fields] OR \"heterogeneous\"[All Fields] OR \"heterogeneously\"[All Fields] OR \"heterogenic\"[All Fields] OR \"heterogenicity\"[All Fields] OR \"heterogenities\"[All Fields] OR \"heterogenity\"[All Fields] OR \"heterogenization\"[All Fields] OR \"heterogenized\"[All Fields] OR \"heterogenizing\"[All Fields] OR \"heterogenous\"[All Fields] OR \"heterogenously\"[All Fields]) OR \"phenotype*\"[All Fields] OR (\"diagnosis\"[MeSH Subheading] OR \"diagnosis\"[All Fields] OR \"screening\"[All Fields] OR \"mass screening\"[MeSH Terms] OR (\"mass\"[All Fields] AND \"screening\"[All Fields]) OR \"mass screening\"[All Fields] OR \"early detection of cancer\"[MeSH Terms] OR (\"early\"[All Fields] AND \"detection\"[All Fields] AND \"cancer\"[All Fields]) OR \"early detection of cancer\"[All Fields] OR \"screen\"[All Fields] OR \"screenings\"[All Fields] OR \"screened\"[All Fields] OR \"screens\"[All Fields]) OR \"mixed features\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "burden",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (epidemiology OR prevalence OR incidence OR \"global burden\" OR \"treatment gap\" OR registry) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"epidemiologies\"[All Fields] OR \"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"epidemiology\"[MeSH Terms] OR \"epidemiology s\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields]) OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR \"global burden\"[All Fields] OR \"treatment gap\"[All Fields] OR (\"registries\"[MeSH Terms] OR \"registries\"[All Fields] OR \"registry\"[All Fields] OR \"registry s\"[All Fields])) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 253,
      "ids": [
        "42901213",
        "42898229",
        "42896217",
        "42892401",
        "42892095",
        "42891241",
        "42889194",
        "42887092",
        "42886483",
        "42885693",
        "42879916",
        "42872469",
        "42872125",
        "42871390",
        "42867189",
        "42866493",
        "42864498",
        "42862569",
        "42862091",
        "42861501",
        "42858801",
        "42858520",
        "42858466",
        "42858455",
        "42856559",
        "42855248",
        "42854791",
        "42850904",
        "42850268",
        "42849853",
        "42844936",
        "42844674",
        "42843279",
        "42841964",
        "42841672",
        "42840883",
        "42838229",
        "42837085",
        "42836998",
        "42834832",
        "42828816",
        "42826878",
        "42826821",
        "42826766",
        "42822232",
        "42820260",
        "42819210",
        "42818885",
        "42818201",
        "42817096",
        "42815877",
        "42815731",
        "42813267",
        "42809770",
        "42806365",
        "42804205",
        "42803904",
        "42803346",
        "42802397",
        "42802390",
        "42799588",
        "42799462",
        "42798114",
        "42795740",
        "42794622",
        "42794551",
        "42792385",
        "42791907",
        "42787777",
        "42787408",
        "42785386",
        "42779163",
        "42778028",
        "42776545",
        "42771084",
        "42767626",
        "42766849",
        "42765892",
        "42765208",
        "42765137",
        "42761770",
        "42760730",
        "42760705",
        "42758600",
        "42758324",
        "42756843",
        "42756839",
        "42755741",
        "42754771",
        "42753853",
        "42749881",
        "42748866",
        "42748377",
        "42744145",
        "42739724",
        "42735274",
        "42733696",
        "42732835",
        "42731592",
        "42731320",
        "42728813",
        "42727204",
        "42726636",
        "42725261",
        "42722435",
        "42721518",
        "42716277",
        "42715127",
        "42714373",
        "42714093",
        "42713675",
        "32644424",
        "42710693",
        "42707709",
        "42705422",
        "42705400",
        "42705027",
        "42701687",
        "42700488",
        "42700487",
        "42698872",
        "42698078",
        "42696738",
        "42695158",
        "42695028",
        "42691037",
        "42688558",
        "42686352",
        "42686075",
        "42685988",
        "42682977",
        "42681589",
        "42680114",
        "42679360",
        "42675332",
        "42671502",
        "42670435",
        "42670051",
        "42664168",
        "42663608",
        "42658152",
        "42649425",
        "42649390",
        "42640305",
        "42635055",
        "42633314",
        "42625058",
        "42624134",
        "42612565",
        "42607586",
        "42600677",
        "42594760",
        "42584886",
        "42577036",
        "42567088",
        "42562964",
        "42530607",
        "42524749",
        "42498428",
        "42494826",
        "42475069",
        "42474069",
        "42435748",
        "42432162",
        "42425098",
        "42418908",
        "42384049",
        "42384048",
        "42383885",
        "42383744",
        "42379544",
        "42379070",
        "42377482",
        "42377414",
        "42364507",
        "42364336",
        "42361653",
        "42358003",
        "42349103",
        "42339150",
        "42337416",
        "42320979",
        "42320286",
        "42320285",
        "42314447",
        "42302888",
        "42301395",
        "42298346",
        "42284804",
        "42269957",
        "42269542",
        "42267832",
        "42263954",
        "42230966",
        "42217371",
        "42215638",
        "42211077",
        "42203004",
        "42190845",
        "42184716",
        "42184575",
        "42178053",
        "42173043",
        "42167696",
        "42155212",
        "42144137",
        "42142759",
        "42134745",
        "42134004",
        "42119282",
        "42119185",
        "42115366",
        "42107849",
        "42107653",
        "42105580",
        "42105579",
        "42092398",
        "42087765",
        "42084387",
        "42081006",
        "42070122",
        "42055128",
        "42035454",
        "42031013",
        "42013686",
        "41999998",
        "41968289",
        "41951544",
        "41923473",
        "41904070",
        "41880255",
        "41804951",
        "41791639",
        "41790247",
        "41763442",
        "41758223",
        "41582323",
        "41558805",
        "41547389",
        "41534638",
        "41513565",
        "41434748",
        "41429013",
        "41319841",
        "41275966",
        "41247288",
        "40996024",
        "40977395",
        "40935332",
        "40875158",
        "40830864",
        "40204235",
        "39964582"
      ],
      "http": 200
    },
    {
      "topic": "burden",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (epidemiology OR prevalence OR incidence OR \"global burden\" OR \"treatment gap\" OR registry) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"epidemiologies\"[All Fields] OR \"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"epidemiology\"[MeSH Terms] OR \"epidemiology s\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields]) OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR \"global burden\"[All Fields] OR \"treatment gap\"[All Fields] OR (\"registries\"[MeSH Terms] OR \"registries\"[All Fields] OR \"registry\"[All Fields] OR \"registry s\"[All Fields])) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "mechanisms",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (neurobiolog* OR neuroinflamm* OR \"HPA axis\" OR BDNF OR \"neural circuit\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"neurobiolog*\"[All Fields] OR \"neuroinflamm*\"[All Fields] OR \"HPA axis\"[All Fields] OR (\"brain derived neurotrophic factor\"[Supplementary Concept] OR \"brain derived neurotrophic factor\"[All Fields] OR \"bdnf\"[All Fields] OR \"brain derived neurotrophic factor\"[MeSH Terms] OR (\"brain derived\"[All Fields] AND \"neurotrophic\"[All Fields] AND \"factor\"[All Fields])) OR \"neural circuit\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 155,
      "ids": [
        "42897264",
        "42895100",
        "42893748",
        "42892095",
        "42889292",
        "42887658",
        "42884023",
        "42883782",
        "42883713",
        "42874001",
        "42871390",
        "42870751",
        "42860592",
        "42858520",
        "42850268",
        "42842414",
        "42841964",
        "42840883",
        "42838181",
        "42828817",
        "42826818",
        "42826634",
        "42826581",
        "42819418",
        "42818885",
        "42817096",
        "42813034",
        "42810627",
        "42809944",
        "42807528",
        "42807520",
        "42806433",
        "42805955",
        "42805590",
        "42803524",
        "42797527",
        "42797287",
        "42794551",
        "42794424",
        "42793276",
        "42783499",
        "42778028",
        "42777979",
        "42773517",
        "42771937",
        "42771073",
        "42770453",
        "42770452",
        "42768143",
        "42767040",
        "42766483",
        "42765605",
        "42765387",
        "42764140",
        "42763338",
        "42762784",
        "42762770",
        "42762287",
        "42753853",
        "42752951",
        "42745799",
        "42745218",
        "42744142",
        "42737858",
        "42735276",
        "42734915",
        "42731592",
        "42729906",
        "42729560",
        "42728701",
        "42724084",
        "42723246",
        "42723086",
        "42721112",
        "42715443",
        "42710732",
        "42710718",
        "42710528",
        "42709645",
        "42707775",
        "42707762",
        "42707709",
        "42704208",
        "42702788",
        "42700763",
        "42696458",
        "42692098",
        "42688891",
        "42686088",
        "42686075",
        "42685988",
        "42679360",
        "42676104",
        "42671502",
        "42670051",
        "42668072",
        "42663293",
        "42630054",
        "42620154",
        "42613180",
        "42600677",
        "42580506",
        "42577036",
        "42572461",
        "42567088",
        "42543058",
        "42532352",
        "42508695",
        "42498564",
        "42494826",
        "42492720",
        "42435748",
        "42419634",
        "42414566",
        "42384049",
        "42349103",
        "42331234",
        "42322911",
        "42320286",
        "42307972",
        "42297310",
        "42296874",
        "42294641",
        "42263954",
        "42210495",
        "42178053",
        "42168587",
        "42155857",
        "42151503",
        "42144135",
        "42140323",
        "42129477",
        "42127355",
        "42119909",
        "42105580",
        "42092578",
        "42090938",
        "42086176",
        "42070700",
        "42055138",
        "42055137",
        "42055130",
        "42055128",
        "42050011",
        "42049070",
        "42044556",
        "42020763",
        "42020719",
        "41968289",
        "41963179",
        "41791639",
        "41581557",
        "41534638",
        "41307243",
        "40204235"
      ],
      "http": 200
    },
    {
      "topic": "mechanisms",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (neurobiolog* OR neuroinflamm* OR \"HPA axis\" OR BDNF OR \"neural circuit\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"neurobiolog*\"[All Fields] OR \"neuroinflamm*\"[All Fields] OR \"HPA axis\"[All Fields] OR (\"brain derived neurotrophic factor\"[Supplementary Concept] OR \"brain derived neurotrophic factor\"[All Fields] OR \"bdnf\"[All Fields] OR \"brain derived neurotrophic factor\"[MeSH Terms] OR (\"brain derived\"[All Fields] AND \"neurotrophic\"[All Fields] AND \"factor\"[All Fields])) OR \"neural circuit\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "genetics",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (genetic* OR GWAS OR polygenic OR epigenetic* OR ancestry) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"genetic*\"[All Fields] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields]) OR (\"polygene\"[All Fields] OR \"polygenes\"[All Fields] OR \"polygenic\"[All Fields] OR \"polygenically\"[All Fields] OR \"polygenicity\"[All Fields]) OR \"epigenetic*\"[All Fields] OR (\"ancestries\"[All Fields] OR \"ancestry\"[All Fields])) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 163,
      "ids": [
        "42901213",
        "42895100",
        "42894926",
        "28520380",
        "42892769",
        "42892069",
        "42891334",
        "42891141",
        "42890752",
        "42887784",
        "42886804",
        "42886211",
        "42884023",
        "42879530",
        "42876217",
        "42874001",
        "42872493",
        "42871888",
        "42871390",
        "42862091",
        "42861501",
        "42858520",
        "42858466",
        "42856559",
        "42853203",
        "42850268",
        "42839001",
        "42836998",
        "42835756",
        "42834754",
        "42833865",
        "42831370",
        "42830219",
        "42829528",
        "42826767",
        "42818443",
        "42818201",
        "42817096",
        "42814113",
        "42807520",
        "42807437",
        "42806433",
        "42803524",
        "42803521",
        "42803346",
        "42792438",
        "42791907",
        "42786261",
        "42785386",
        "42779037",
        "42778763",
        "42777979",
        "42773889",
        "42771937",
        "42771084",
        "42768143",
        "42767513",
        "42765387",
        "42765137",
        "42764573",
        "42760730",
        "42749774",
        "42749498",
        "42744145",
        "42742582",
        "42732835",
        "42728740",
        "42716055",
        "42715443",
        "42710732",
        "42710693",
        "42709645",
        "42706232",
        "42700945",
        "42696128",
        "42693300",
        "42688891",
        "42682166",
        "42679763",
        "42670435",
        "42669383",
        "42668072",
        "42667302",
        "42649423",
        "42649390",
        "42640306",
        "42633314",
        "42632223",
        "42630054",
        "42629468",
        "42625058",
        "42623125",
        "42620154",
        "42617977",
        "42613180",
        "42598999",
        "42595040",
        "42584886",
        "42580506",
        "42572938",
        "42569312",
        "42543058",
        "42537476",
        "42517234",
        "42485789",
        "42471042",
        "42462453",
        "42435748",
        "42425053",
        "42419634",
        "42418908",
        "42377483",
        "42364336",
        "42350629",
        "42320979",
        "42320287",
        "42320286",
        "42316910",
        "42314449",
        "42307972",
        "42296874",
        "42267832",
        "42252042",
        "42250361",
        "42230966",
        "42210495",
        "42203964",
        "42190845",
        "42178053",
        "42155857",
        "42144135",
        "42142759",
        "42134742",
        "42120555",
        "42119908",
        "42107849",
        "42105580",
        "42100925",
        "42098399",
        "42092578",
        "42092402",
        "42092400",
        "42055137",
        "42050011",
        "42047285",
        "42035806",
        "42035799",
        "42020763",
        "42020719",
        "42020718",
        "41968289",
        "41873584",
        "41845545",
        "41794061",
        "41791639",
        "41763442",
        "41761828",
        "41690355",
        "41605285",
        "41547389",
        "41534638",
        "40875158",
        "40204235"
      ],
      "http": 200
    },
    {
      "topic": "genetics",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (genetic* OR GWAS OR polygenic OR epigenetic* OR ancestry) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"genetic*\"[All Fields] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields]) OR (\"polygene\"[All Fields] OR \"polygenes\"[All Fields] OR \"polygenic\"[All Fields] OR \"polygenically\"[All Fields] OR \"polygenicity\"[All Fields]) OR \"epigenetic*\"[All Fields] OR (\"ancestries\"[All Fields] OR \"ancestry\"[All Fields])) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "antidepressants",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (antidepressant* OR SSRI OR SNRI OR withdrawal OR discontinuation OR \"sexual dysfunction\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"antidepressant*\"[All Fields] OR (\"selective serotonin reuptake inhibitors\"[Pharmacological Action] OR \"selective serotonin reuptake inhibitors\"[Supplementary Concept] OR \"selective serotonin reuptake inhibitors\"[All Fields] OR \"ssri\"[All Fields] OR \"selective serotonin reuptake inhibitors\"[MeSH Terms] OR (\"selective\"[All Fields] AND \"serotonin\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"serotonin and noradrenaline reuptake inhibitors\"[Pharmacological Action] OR \"serotonin and noradrenaline reuptake inhibitors\"[Supplementary Concept] OR \"serotonin and noradrenaline reuptake inhibitors\"[All Fields] OR \"snri\"[All Fields] OR \"serotonin and noradrenaline reuptake inhibitors\"[MeSH Terms] OR (\"serotonin\"[All Fields] AND \"noradrenaline\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"withdraw\"[All Fields] OR \"withdrawal\"[All Fields] OR \"withdrawals\"[All Fields] OR \"withdrawing\"[All Fields] OR \"withdraws\"[All Fields]) OR (\"discontinuance\"[All Fields] OR \"discontinuances\"[All Fields] OR \"discontinuated\"[All Fields] OR \"discontinuation\"[All Fields] OR \"discontinuations\"[All Fields] OR \"discontinue\"[All Fields] OR \"discontinued\"[All Fields] OR \"discontinuer\"[All Fields] OR \"discontinuers\"[All Fields] OR \"discontinues\"[All Fields] OR \"discontinuing\"[All Fields]) OR \"sexual dysfunction\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 228,
      "ids": [
        "42901397",
        "42901213",
        "42899015",
        "42896406",
        "42895746",
        "42895100",
        "42894926",
        "42894301",
        "28520380",
        "42892401",
        "42892100",
        "42890690",
        "42889347",
        "42889292",
        "42888351",
        "42887658",
        "42886804",
        "42883713",
        "42879530",
        "42877783",
        "42875717",
        "42871888",
        "42870348",
        "42869167",
        "42866549",
        "42863798",
        "42863557",
        "42861207",
        "42858801",
        "42858129",
        "42856566",
        "42850904",
        "42842414",
        "42841964",
        "42839386",
        "42838387",
        "42838181",
        "42835756",
        "42834741",
        "42832766",
        "42829528",
        "42826878",
        "42819418",
        "42818885",
        "42818515",
        "42817096",
        "42815037",
        "42814927",
        "42814111",
        "42812942",
        "42812643",
        "42812173",
        "42805662",
        "42805099",
        "42803521",
        "42801835",
        "42799904",
        "42797287",
        "42795930",
        "42795740",
        "42793276",
        "42792385",
        "42788073",
        "42786817",
        "42785392",
        "42784817",
        "42783499",
        "42778211",
        "42774912",
        "42770597",
        "42769822",
        "42769711",
        "42767626",
        "42767564",
        "42767040",
        "42766849",
        "42766673",
        "42766019",
        "42763552",
        "42762641",
        "42761770",
        "42756843",
        "42756839",
        "42753853",
        "42752587",
        "42751846",
        "42750362",
        "42750260",
        "42739877",
        "42736557",
        "42735274",
        "30725910",
        "28613681",
        "42732834",
        "42731592",
        "42729560",
        "42729393",
        "42729184",
        "42728072",
        "42727730",
        "42727635",
        "42725261",
        "42724084",
        "42722435",
        "42716345",
        "42716055",
        "42715443",
        "42715127",
        "42710716",
        "42710412",
        "42707709",
        "42705363",
        "42702010",
        "42701679",
        "42701110",
        "42700488",
        "42696738",
        "42696458",
        "42695158",
        "42692098",
        "42690086",
        "42688594",
        "42686996",
        "42684694",
        "42684061",
        "42682977",
        "42680855",
        "42680119",
        "42679360",
        "42674239",
        "42670957",
        "42668390",
        "42668254",
        "42668072",
        "42667302",
        "42665164",
        "42664168",
        "42663293",
        "42658027",
        "42642808",
        "42640306",
        "42640305",
        "42628206",
        "42621346",
        "42616023",
        "42610482",
        "42595101",
        "42595040",
        "42584886",
        "42581396",
        "42580506",
        "42572461",
        "42562964",
        "42556713",
        "42550483",
        "42532352",
        "42531622",
        "42524749",
        "42522066",
        "42518156",
        "42508605",
        "42508527",
        "42508525",
        "42494826",
        "42492718",
        "42475069",
        "42470859",
        "42462453",
        "42455478",
        "42435731",
        "42418124",
        "42414566",
        "42413809",
        "42411994",
        "42410139",
        "42384049",
        "42379544",
        "42379141",
        "42362819",
        "42361653",
        "42341411",
        "42322911",
        "42307972",
        "42302638",
        "42284801",
        "42283956",
        "42276172",
        "42264040",
        "42263954",
        "42252042",
        "42250361",
        "42248243",
        "42242455",
        "42203004",
        "42176815",
        "42176813",
        "42169234",
        "42168587",
        "42167696",
        "42151503",
        "42131982",
        "42129477",
        "42127355",
        "42119282",
        "42115366",
        "42107656",
        "42105579",
        "42103244",
        "42086176",
        "42065494",
        "42055130",
        "42050011",
        "42047285",
        "42035805",
        "41986746",
        "41963179",
        "41904070",
        "41903946",
        "41873584",
        "41817153",
        "41814584",
        "41807319",
        "41804951",
        "41691708",
        "41558805",
        "41534638",
        "41111092",
        "40977395"
      ],
      "http": 200
    },
    {
      "topic": "antidepressants",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (antidepressant* OR SSRI OR SNRI OR withdrawal OR discontinuation OR \"sexual dysfunction\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"antidepressant*\"[All Fields] OR (\"selective serotonin reuptake inhibitors\"[Pharmacological Action] OR \"selective serotonin reuptake inhibitors\"[Supplementary Concept] OR \"selective serotonin reuptake inhibitors\"[All Fields] OR \"ssri\"[All Fields] OR \"selective serotonin reuptake inhibitors\"[MeSH Terms] OR (\"selective\"[All Fields] AND \"serotonin\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"serotonin and noradrenaline reuptake inhibitors\"[Pharmacological Action] OR \"serotonin and noradrenaline reuptake inhibitors\"[Supplementary Concept] OR \"serotonin and noradrenaline reuptake inhibitors\"[All Fields] OR \"snri\"[All Fields] OR \"serotonin and noradrenaline reuptake inhibitors\"[MeSH Terms] OR (\"serotonin\"[All Fields] AND \"noradrenaline\"[All Fields] AND \"reuptake\"[All Fields] AND \"inhibitors\"[All Fields])) OR (\"withdraw\"[All Fields] OR \"withdrawal\"[All Fields] OR \"withdrawals\"[All Fields] OR \"withdrawing\"[All Fields] OR \"withdraws\"[All Fields]) OR (\"discontinuance\"[All Fields] OR \"discontinuances\"[All Fields] OR \"discontinuated\"[All Fields] OR \"discontinuation\"[All Fields] OR \"discontinuations\"[All Fields] OR \"discontinue\"[All Fields] OR \"discontinued\"[All Fields] OR \"discontinuer\"[All Fields] OR \"discontinuers\"[All Fields] OR \"discontinues\"[All Fields] OR \"discontinuing\"[All Fields]) OR \"sexual dysfunction\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "efficacy",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (\"publication bias\" OR placebo OR STAR*D OR \"clinical significance\" OR \"individual participant\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"publication bias\"[All Fields] OR (\"placeboes\"[All Fields] OR \"placebos\"[Supplementary Concept] OR \"placebos\"[All Fields] OR \"placebo\"[All Fields] OR \"placebos\"[MeSH Terms]) OR \"star*d\"[All Fields] OR \"clinical significance\"[All Fields] OR \"individual participant\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 43,
      "ids": [
        "42892401",
        "42877783",
        "42870348",
        "42863798",
        "42858520",
        "42815730",
        "42812942",
        "42802397",
        "42789363",
        "42778211",
        "42774912",
        "42766673",
        "42752587",
        "42733696",
        "42729393",
        "42721112",
        "42701110",
        "42690086",
        "42688558",
        "42684061",
        "42680855",
        "42680119",
        "42670051",
        "42610482",
        "42562964",
        "42550483",
        "42522066",
        "42494826",
        "42470859",
        "42455478",
        "42435731",
        "42414566",
        "42383744",
        "42350630",
        "42283956",
        "42252042",
        "42176815",
        "42176813",
        "42140323",
        "41963179",
        "41790247",
        "41558805",
        "41191045"
      ],
      "http": 200
    },
    {
      "topic": "efficacy",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (\"publication bias\" OR placebo OR STAR*D OR \"clinical significance\" OR \"individual participant\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"publication bias\"[All Fields] OR (\"placeboes\"[All Fields] OR \"placebos\"[Supplementary Concept] OR \"placebos\"[All Fields] OR \"placebo\"[All Fields] OR \"placebos\"[MeSH Terms]) OR \"star*d\"[All Fields] OR \"clinical significance\"[All Fields] OR \"individual participant\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "psychotherapy",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (psychotherap* OR \"cognitive behavioral\" OR \"behavioural activation\" OR exercise OR \"task sharing\" OR \"task-shared\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"psychotherap*\"[All Fields] OR \"cognitive behavioral\"[All Fields] OR \"behavioural activation\"[All Fields] OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]) OR \"task sharing\"[All Fields] OR \"task-shared\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 119,
      "ids": [
        "42896406",
        "42895746",
        "42892100",
        "42892095",
        "42889347",
        "42886483",
        "42879686",
        "42879530",
        "42877783",
        "42872182",
        "42869999",
        "42865326",
        "42863798",
        "42863717",
        "42858129",
        "42854791",
        "42844936",
        "42843278",
        "42839301",
        "42838229",
        "42835728",
        "42834832",
        "42815884",
        "42812173",
        "42807040",
        "42805955",
        "42801310",
        "42799904",
        "42796411",
        "42795740",
        "42792385",
        "42789363",
        "42789054",
        "42785391",
        "42784817",
        "42779037",
        "42766019",
        "42756843",
        "42756688",
        "42750260",
        "42749161",
        "42736557",
        "42735276",
        "42734915",
        "42732835",
        "42732834",
        "42732542",
        "42726702",
        "42725261",
        "42724084",
        "42714093",
        "42710691",
        "42709645",
        "42700486",
        "42686352",
        "42682977",
        "42680855",
        "42679601",
        "42678888",
        "42669842",
        "42669383",
        "42664168",
        "42640306",
        "42632223",
        "42625058",
        "42612565",
        "42567088",
        "42562964",
        "42558024",
        "42550483",
        "42550193",
        "42518170",
        "42485789",
        "42475069",
        "42470859",
        "42435731",
        "42432162",
        "42425188",
        "42425030",
        "42418908",
        "42418124",
        "42413809",
        "42411994",
        "42384049",
        "42383885",
        "42379068",
        "42362819",
        "42294641",
        "42284801",
        "42269957",
        "42269542",
        "42263954",
        "42248243",
        "42217371",
        "42215638",
        "42184575",
        "42169234",
        "42155212",
        "42140319",
        "42134745",
        "42131982",
        "42129477",
        "42119908",
        "42119282",
        "42107658",
        "42096803",
        "42070700",
        "42047285",
        "42014469",
        "42002221",
        "41991348",
        "41807319",
        "41791639",
        "41787762",
        "41690355",
        "41558805",
        "40830864",
        "40204235",
        "40184540"
      ],
      "http": 200
    },
    {
      "topic": "psychotherapy",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (psychotherap* OR \"cognitive behavioral\" OR \"behavioural activation\" OR exercise OR \"task sharing\" OR \"task-shared\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"psychotherap*\"[All Fields] OR \"cognitive behavioral\"[All Fields] OR \"behavioural activation\"[All Fields] OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]) OR \"task sharing\"[All Fields] OR \"task-shared\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "resistance",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (\"treatment resistant\" OR \"treatment-resistant\" OR augmentation OR lithium OR sequencing) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"treatment-resistant\"[All Fields] OR \"treatment-resistant\"[All Fields] OR (\"augment\"[All Fields] OR \"augmentation\"[All Fields] OR \"augmentations\"[All Fields] OR \"augmented\"[All Fields] OR \"augmenting\"[All Fields] OR \"augments\"[All Fields]) OR (\"lithium\"[Supplementary Concept] OR \"lithium\"[All Fields] OR \"lithium\"[MeSH Terms] OR \"lithium s\"[All Fields] OR \"lithiums\"[All Fields]) OR (\"base sequence\"[MeSH Terms] OR (\"base\"[All Fields] AND \"sequence\"[All Fields]) OR \"base sequence\"[All Fields] OR \"sequence\"[All Fields] OR \"sequences\"[All Fields] OR \"sequence analysis\"[MeSH Terms] OR (\"sequence\"[All Fields] AND \"analysis\"[All Fields]) OR \"sequence analysis\"[All Fields] OR \"sequencing\"[All Fields] OR \"sequence s\"[All Fields] OR \"sequenceable\"[All Fields] OR \"sequenced\"[All Fields] OR \"sequenceing\"[All Fields] OR \"sequencer\"[All Fields] OR \"sequencers\"[All Fields] OR \"sequencies\"[All Fields] OR \"sequencings\"[All Fields])) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 158,
      "ids": [
        "42896406",
        "42895100",
        "42892401",
        "42892100",
        "42890690",
        "42889292",
        "42887658",
        "42879530",
        "42878501",
        "42878230",
        "42876217",
        "42870751",
        "42870348",
        "42869167",
        "42865326",
        "42864698",
        "42864498",
        "42863798",
        "42861501",
        "42858129",
        "42856359",
        "42849015",
        "42844676",
        "42844674",
        "42843471",
        "42841964",
        "42840696",
        "42831370",
        "42830219",
        "42829941",
        "42818885",
        "42818515",
        "42818201",
        "42817096",
        "42815730",
        "42814927",
        "42813034",
        "42812942",
        "42812173",
        "42807040",
        "42803524",
        "42799904",
        "42789054",
        "42788073",
        "42783499",
        "42783367",
        "42778763",
        "42771084",
        "42769103",
        "42768327",
        "42767513",
        "42767040",
        "42766673",
        "42766497",
        "42766019",
        "42765892",
        "42762641",
        "42761770",
        "42760730",
        "42756843",
        "42756688",
        "42756176",
        "42753254",
        "42751846",
        "42749498",
        "42748866",
        "42745306",
        "42745218",
        "42744145",
        "42742966",
        "42736349",
        "30855854",
        "42732835",
        "42732834",
        "42732542",
        "42729848",
        "42728740",
        "42727730",
        "42721112",
        "42711407",
        "42702010",
        "42700945",
        "42700487",
        "42699006",
        "42690530",
        "42686996",
        "42684694",
        "42684061",
        "42682977",
        "42682166",
        "42679763",
        "42679236",
        "42678910",
        "42675468",
        "42668390",
        "42663266",
        "42658152",
        "42658027",
        "42649423",
        "42649390",
        "42642808",
        "42630054",
        "42629468",
        "42625058",
        "42620154",
        "42613180",
        "42598999",
        "42580506",
        "42562964",
        "42542090",
        "42532352",
        "42531622",
        "42518156",
        "42517234",
        "42508605",
        "42502622",
        "42492720",
        "42435748",
        "42383744",
        "42379141",
        "42379068",
        "42377483",
        "42364336",
        "42339150",
        "42320287",
        "42307972",
        "42302659",
        "42302638",
        "42267832",
        "42248243",
        "42240040",
        "42230966",
        "42219697",
        "42210495",
        "42203964",
        "42144137",
        "42140321",
        "42127355",
        "42119282",
        "42107849",
        "42100925",
        "42065494",
        "42050011",
        "42035806",
        "42035799",
        "42020763",
        "42020719",
        "42020718",
        "41963179",
        "41904070",
        "41873584",
        "41814584",
        "41763442",
        "41761828",
        "41605285",
        "41558805",
        "41111092",
        "40875158"
      ],
      "http": 200
    },
    {
      "topic": "resistance",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (\"treatment resistant\" OR \"treatment-resistant\" OR augmentation OR lithium OR sequencing) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"treatment-resistant\"[All Fields] OR \"treatment-resistant\"[All Fields] OR (\"augment\"[All Fields] OR \"augmentation\"[All Fields] OR \"augmentations\"[All Fields] OR \"augmented\"[All Fields] OR \"augmenting\"[All Fields] OR \"augments\"[All Fields]) OR (\"lithium\"[Supplementary Concept] OR \"lithium\"[All Fields] OR \"lithium\"[MeSH Terms] OR \"lithium s\"[All Fields] OR \"lithiums\"[All Fields]) OR (\"base sequence\"[MeSH Terms] OR (\"base\"[All Fields] AND \"sequence\"[All Fields]) OR \"base sequence\"[All Fields] OR \"sequence\"[All Fields] OR \"sequences\"[All Fields] OR \"sequence analysis\"[MeSH Terms] OR (\"sequence\"[All Fields] AND \"analysis\"[All Fields]) OR \"sequence analysis\"[All Fields] OR \"sequencing\"[All Fields] OR \"sequence s\"[All Fields] OR \"sequenceable\"[All Fields] OR \"sequenced\"[All Fields] OR \"sequenceing\"[All Fields] OR \"sequencer\"[All Fields] OR \"sequencers\"[All Fields] OR \"sequencies\"[All Fields] OR \"sequencings\"[All Fields])) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "glutamatergic",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (ketamine OR esketamine OR dextromethorphan OR hydroxynorketamine OR zelquistinel) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"ketamin\"[All Fields] OR \"ketamine\"[Supplementary Concept] OR \"ketamine\"[All Fields] OR \"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields] OR \"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields] OR \"ketamine\"[MeSH Terms] OR \"ketamine s\"[All Fields] OR \"ketamines\"[All Fields] OR (\"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields]) OR (\"dextromethorphan\"[Supplementary Concept] OR \"dextromethorphan\"[All Fields] OR \"dextromethorphan\"[MeSH Terms] OR \"dextromethorphane\"[All Fields]) OR \"hydroxynorketamine\"[All Fields] OR \"zelquistinel\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 53,
      "ids": [
        "42896406",
        "42894304",
        "42894301",
        "42894300",
        "42889292",
        "42879530",
        "42877783",
        "42869167",
        "42865326",
        "42863798",
        "42858129",
        "42838387",
        "42835728",
        "42812942",
        "42803524",
        "42767564",
        "42767040",
        "42762641",
        "42756688",
        "42755741",
        "42748866",
        "42735276",
        "42721112",
        "42702010",
        "42692098",
        "42684694",
        "42682977",
        "42663266",
        "42616023",
        "42610482",
        "42572461",
        "42562964",
        "42556713",
        "42531622",
        "42522066",
        "42518156",
        "42508525",
        "42384049",
        "42377483",
        "42302638",
        "42240040",
        "42217548",
        "42151503",
        "42140321",
        "42103244",
        "42065494",
        "41873584",
        "41844563",
        "41814584",
        "41582323",
        "41191045",
        "41111092",
        "39964582"
      ],
      "http": 200
    },
    {
      "topic": "glutamatergic",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (ketamine OR esketamine OR dextromethorphan OR hydroxynorketamine OR zelquistinel) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"ketamin\"[All Fields] OR \"ketamine\"[Supplementary Concept] OR \"ketamine\"[All Fields] OR \"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields] OR \"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields] OR \"ketamine\"[MeSH Terms] OR \"ketamine s\"[All Fields] OR \"ketamines\"[All Fields] OR (\"esketamine\"[Supplementary Concept] OR \"esketamine\"[All Fields]) OR (\"dextromethorphan\"[Supplementary Concept] OR \"dextromethorphan\"[All Fields] OR \"dextromethorphan\"[MeSH Terms] OR \"dextromethorphane\"[All Fields]) OR \"hydroxynorketamine\"[All Fields] OR \"zelquistinel\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "neuromodulation",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (electroconvulsive OR \"transcranial magnetic\" OR iTBS OR tDCS OR \"vagus nerve\" OR \"deep brain stimulation\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"electroconvulsant\"[All Fields] OR \"electroconvulsion\"[All Fields] OR \"electroconvulsions\"[All Fields] OR \"electroconvulsive\"[All Fields] OR \"transcranial magnetic\"[All Fields] OR \"iTBS\"[All Fields] OR (\"transcranial direct current stimulation\"[MeSH Terms] OR (\"transcranial\"[All Fields] AND \"direct\"[All Fields] AND \"current\"[All Fields] AND \"stimulation\"[All Fields]) OR \"transcranial direct current stimulation\"[All Fields] OR \"tdcs\"[All Fields]) OR \"vagus nerve\"[All Fields] OR \"deep brain stimulation\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 100,
      "ids": [
        "42895746",
        "42892100",
        "42890690",
        "42880443",
        "42879997",
        "42878501",
        "42878230",
        "42877696",
        "42870348",
        "42864698",
        "42863719",
        "42863253",
        "42860592",
        "42858129",
        "42855128",
        "42844676",
        "42844674",
        "42843471",
        "42841964",
        "42839296",
        "42838181",
        "42830939",
        "42829057",
        "42829029",
        "42818515",
        "42810830",
        "42801310",
        "42799904",
        "42789363",
        "42789054",
        "42787626",
        "42785385",
        "42785233",
        "42783367",
        "42769949",
        "42766673",
        "42766019",
        "42762784",
        "42753347",
        "42745306",
        "42745218",
        "42735276",
        "30855854",
        "42731592",
        "42727730",
        "42721517",
        "42721112",
        "42700487",
        "42700486",
        "42699697",
        "42696738",
        "42687377",
        "42686996",
        "42679601",
        "42679236",
        "42676877",
        "42675468",
        "42674239",
        "42668924",
        "42658152",
        "42642808",
        "42628206",
        "42595040",
        "42581396",
        "42524749",
        "42518170",
        "42508605",
        "42502622",
        "42492720",
        "42475069",
        "42398293",
        "42384049",
        "42383744",
        "42341411",
        "42339150",
        "42335495",
        "42302659",
        "42284801",
        "42272332",
        "42265226",
        "42252042",
        "42223086",
        "42219697",
        "42155351",
        "42127355",
        "42115366",
        "42107658",
        "42090938",
        "42086176",
        "42035805",
        "41986746",
        "41862185",
        "41814584",
        "41807319",
        "41690355",
        "40228165",
        "40184540",
        "40168143",
        "40132108",
        "39964582"
      ],
      "http": 200
    },
    {
      "topic": "neuromodulation",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (electroconvulsive OR \"transcranial magnetic\" OR iTBS OR tDCS OR \"vagus nerve\" OR \"deep brain stimulation\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"electroconvulsant\"[All Fields] OR \"electroconvulsion\"[All Fields] OR \"electroconvulsions\"[All Fields] OR \"electroconvulsive\"[All Fields] OR \"transcranial magnetic\"[All Fields] OR \"iTBS\"[All Fields] OR (\"transcranial direct current stimulation\"[MeSH Terms] OR (\"transcranial\"[All Fields] AND \"direct\"[All Fields] AND \"current\"[All Fields] AND \"stimulation\"[All Fields]) OR \"transcranial direct current stimulation\"[All Fields] OR \"tdcs\"[All Fields]) OR \"vagus nerve\"[All Fields] OR \"deep brain stimulation\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "novel",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (psilocybin OR psychedelic* OR neurosteroid* OR zuranolone OR brexanolone OR CYB003 OR \"GM-2505\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation_note": "Rerun after the first call treated phrasesnotfound CYB003 as fatal. Successful esearch count 22. CYB003 remained a phrase-not-found warning and was dropped from the translation; GM-2505 was quoted.",
      "count": 22,
      "ids": [
        "42896406",
        "42869167",
        "42865326",
        "42835728",
        "42834832",
        "42809944",
        "42750260",
        "42735276",
        "42732542",
        "42663266",
        "42658027",
        "42580506",
        "42562964",
        "42531622",
        "42414566",
        "42379141",
        "42320287",
        "42302638",
        "42252042",
        "42215638",
        "41963179",
        "41191045"
      ],
      "http": 200
    },
    {
      "topic": "novel",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (psilocybin OR psychedelic* OR neurosteroid* OR zuranolone OR brexanolone OR CYB003 OR \"GM-2505\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "count": 0,
      "ids": [],
      "http": 200,
      "translation_note": "Same CYB003 phrase-not-found warning. Count 0."
    },
    {
      "topic": "prediction",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (biomarker* OR pharmacogen* OR prediction OR \"machine learning\" OR \"digital phenotyping\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"biomarker*\"[All Fields] OR \"pharmacogen*\"[All Fields] OR (\"predict\"[All Fields] OR \"predictabilities\"[All Fields] OR \"predictability\"[All Fields] OR \"predictable\"[All Fields] OR \"predictably\"[All Fields] OR \"predicted\"[All Fields] OR \"predicting\"[All Fields] OR \"prediction\"[All Fields] OR \"predictions\"[All Fields] OR \"predictive\"[All Fields] OR \"predictively\"[All Fields] OR \"predictiveness\"[All Fields] OR \"predictives\"[All Fields] OR \"predictivities\"[All Fields] OR \"predictivity\"[All Fields] OR \"predicts\"[All Fields]) OR \"machine learning\"[All Fields] OR \"digital phenotyping\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 289,
      "ids": [
        "42901970",
        "42901213",
        "42897683",
        "42896406",
        "42895100",
        "42894926",
        "28520380",
        "42892769",
        "42892100",
        "42892069",
        "42890752",
        "42889194",
        "42887784",
        "42887530",
        "42884380",
        "42884023",
        "42883782",
        "42883713",
        "42878501",
        "42877696",
        "42876953",
        "42875717",
        "42874811",
        "42873387",
        "42872493",
        "42872182",
        "42871667",
        "42871390",
        "42870751",
        "42869999",
        "42866549",
        "42863253",
        "42861501",
        "42861312",
        "42860592",
        "42858801",
        "42858129",
        "42856566",
        "42856559",
        "42855128",
        "42851958",
        "42846268",
        "42844674",
        "42843469",
        "42843279",
        "42841964",
        "42840883",
        "42840696",
        "42839301",
        "42838181",
        "42834754",
        "42833865",
        "42833406",
        "42832644",
        "42831370",
        "42830939",
        "42829528",
        "42829057",
        "42826878",
        "42826821",
        "42826818",
        "42826767",
        "42826634",
        "42826067",
        "42822715",
        "42822187",
        "42820260",
        "42818201",
        "42815884",
        "42815731",
        "42813034",
        "42812173",
        "42811409",
        "42810830",
        "42810627",
        "42806848",
        "42806433",
        "42805955",
        "42805099",
        "42803524",
        "42801835",
        "42799620",
        "42797527",
        "42796411",
        "42794622",
        "42794551",
        "42794424",
        "42792438",
        "42792385",
        "42791907",
        "42788145",
        "42787777",
        "42787408",
        "42785393",
        "42785392",
        "42785391",
        "42785390",
        "42783499",
        "42780703",
        "42777933",
        "42775302",
        "42774912",
        "42773889",
        "42771937",
        "42771084",
        "42770453",
        "42769822",
        "42767042",
        "42766673",
        "42766019",
        "42765861",
        "42765605",
        "42764573",
        "42763552",
        "42758600",
        "42756843",
        "42756839",
        "42756176",
        "42755741",
        "42754579",
        "42753347",
        "42753254",
        "42752951",
        "42752567",
        "42752290",
        "42752169",
        "42751051",
        "42749778",
        "42748377",
        "42745834",
        "42744142",
        "42739724",
        "42737858",
        "42736557",
        "42735276",
        "42734915",
        "30725910",
        "42732880",
        "42732835",
        "42731592",
        "42729848",
        "42726936",
        "42726702",
        "42726636",
        "42725756",
        "42722301",
        "42721164",
        "42721112",
        "42719402",
        "42717271",
        "42716347",
        "42716055",
        "42710732",
        "42710693",
        "42710691",
        "42710528",
        "42710412",
        "42709645",
        "42709166",
        "42707775",
        "42706232",
        "42705363",
        "42702788",
        "42700763",
        "42700487",
        "42699697",
        "42699006",
        "42698909",
        "42698872",
        "42696128",
        "42686996",
        "42686088",
        "42685988",
        "42684674",
        "42682166",
        "42676104",
        "42669383",
        "42668072",
        "42664168",
        "42663293",
        "42660575",
        "42642808",
        "42640306",
        "42636957",
        "42633856",
        "42625058",
        "42624134",
        "42623125",
        "42622332",
        "42621346",
        "42616023",
        "42612565",
        "42598032",
        "42572938",
        "42572461",
        "42565167",
        "42561530",
        "42558024",
        "42546834",
        "42546815",
        "42543058",
        "42542090",
        "42528344",
        "42522354",
        "42522066",
        "42498564",
        "42494826",
        "42492720",
        "42492718",
        "42485972",
        "42474069",
        "42471518",
        "42471042",
        "42470859",
        "42462453",
        "42462416",
        "42435240",
        "42425053",
        "42419634",
        "42414566",
        "42413809",
        "42410139",
        "42399489",
        "42398293",
        "42379544",
        "42379070",
        "42377483",
        "42364336",
        "42362819",
        "42342066",
        "42341411",
        "42337416",
        "42330683",
        "42320286",
        "42307972",
        "42302638",
        "42297310",
        "42276172",
        "42263954",
        "42252042",
        "42250253",
        "42230966",
        "42211077",
        "42210495",
        "42168587",
        "42155212",
        "42151503",
        "42140323",
        "42134744",
        "42131982",
        "42129477",
        "42127355",
        "42120555",
        "42119909",
        "42119908",
        "42107656",
        "42103244",
        "42100925",
        "42092578",
        "42092400",
        "42090938",
        "42086176",
        "42070700",
        "42069105",
        "42055138",
        "42055130",
        "42053632",
        "42050011",
        "42049068",
        "42047285",
        "42044556",
        "42035806",
        "42035799",
        "42031013",
        "42014469",
        "42013686",
        "41986746",
        "41947665",
        "41880255",
        "41817153",
        "41807319",
        "41762174",
        "41581557",
        "41547389",
        "41534638",
        "41191045",
        "40996024",
        "40935332",
        "40689925"
      ],
      "http": 200
    },
    {
      "topic": "prediction",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (biomarker* OR pharmacogen* OR prediction OR \"machine learning\" OR \"digital phenotyping\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"biomarker*\"[All Fields] OR \"pharmacogen*\"[All Fields] OR (\"predict\"[All Fields] OR \"predictabilities\"[All Fields] OR \"predictability\"[All Fields] OR \"predictable\"[All Fields] OR \"predictably\"[All Fields] OR \"predicted\"[All Fields] OR \"predicting\"[All Fields] OR \"prediction\"[All Fields] OR \"predictions\"[All Fields] OR \"predictive\"[All Fields] OR \"predictively\"[All Fields] OR \"predictiveness\"[All Fields] OR \"predictives\"[All Fields] OR \"predictivities\"[All Fields] OR \"predictivity\"[All Fields] OR \"predicts\"[All Fields]) OR \"machine learning\"[All Fields] OR \"digital phenotyping\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "mortality-safety",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (suicid* OR mortality OR safety OR \"adverse effect\" OR mania OR overdose) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"suicid*\"[All Fields] OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading]) OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]) OR \"adverse effect\"[All Fields] OR (\"mania\"[MeSH Terms] OR \"mania\"[All Fields] OR \"manias\"[All Fields]) OR (\"drug overdose\"[MeSH Terms] OR (\"drug\"[All Fields] AND \"overdose\"[All Fields]) OR \"drug overdose\"[All Fields] OR \"overdose\"[All Fields] OR \"overdoses\"[All Fields] OR \"overdosed\"[All Fields] OR \"overdosing\"[All Fields])) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 218,
      "ids": [
        "42901213",
        "42898229",
        "42896217",
        "42895746",
        "42894304",
        "42894300",
        "42892769",
        "42892099",
        "42891241",
        "42889292",
        "42887092",
        "42880603",
        "42880279",
        "42877783",
        "42875717",
        "42872469",
        "42871667",
        "42870751",
        "42866044",
        "42863798",
        "42862594",
        "42862569",
        "42861207",
        "42856559",
        "42855248",
        "42851958",
        "42849853",
        "42849015",
        "42844676",
        "42841964",
        "42841689",
        "42840913",
        "42840696",
        "42838387",
        "42837291",
        "42835728",
        "42830939",
        "42829833",
        "42822715",
        "42818443",
        "42817096",
        "42815731",
        "42814927",
        "42812942",
        "42809770",
        "42804205",
        "42802397",
        "42801835",
        "42799588",
        "42797287",
        "42792450",
        "42788073",
        "42787626",
        "42785386",
        "42785385",
        "42783499",
        "42780377",
        "42779163",
        "42779162",
        "42778211",
        "42774912",
        "42768327",
        "42767564",
        "42767042",
        "42766849",
        "42766019",
        "42765892",
        "42764573",
        "42764140",
        "42758600",
        "42757108",
        "42756688",
        "42755741",
        "42753853",
        "42753254",
        "42752169",
        "42751846",
        "42750260",
        "42745306",
        "42745218",
        "42742582",
        "42739724",
        "42737920",
        "42736557",
        "42734915",
        "30855854",
        "30725910",
        "28613681",
        "42732835",
        "42732834",
        "42732542",
        "42731592",
        "42731320",
        "42729393",
        "42727204",
        "42725756",
        "42722619",
        "42721198",
        "42721164",
        "42720675",
        "42714373",
        "32644424",
        "42710718",
        "42710716",
        "42710412",
        "42706232",
        "31747213",
        "42705422",
        "42701679",
        "42701110",
        "42698177",
        "42698078",
        "42696738",
        "42696532",
        "42693223",
        "42692098",
        "42689366",
        "42687377",
        "42686352",
        "42686074",
        "42685988",
        "42684694",
        "42684674",
        "42682977",
        "42680855",
        "42679236",
        "42678910",
        "42670435",
        "42668390",
        "42663608",
        "42663293",
        "42663266",
        "42658152",
        "42658027",
        "42649425",
        "42642808",
        "42633856",
        "42629468",
        "42628206",
        "42616023",
        "42610482",
        "42584886",
        "42581396",
        "42571148",
        "42562964",
        "42518156",
        "42517234",
        "42508605",
        "42502622",
        "42494826",
        "42470859",
        "42455478",
        "42425098",
        "42419463",
        "42410139",
        "42399489",
        "42361653",
        "42335495",
        "42320979",
        "42320286",
        "42314447",
        "42310163",
        "42307972",
        "42302888",
        "42301395",
        "42298346",
        "42296874",
        "42284804",
        "42283956",
        "42269542",
        "42267832",
        "42265226",
        "42250361",
        "42240040",
        "42223086",
        "42217371",
        "42215638",
        "42210495",
        "42203004",
        "42173043",
        "42169234",
        "42167697",
        "42167696",
        "42155351",
        "42155212",
        "42144137",
        "42140319",
        "42134004",
        "42131982",
        "42115366",
        "42107658",
        "42107653",
        "42106071",
        "42105579",
        "42092398",
        "42069105",
        "42055137",
        "42031014",
        "42031013",
        "42014469",
        "42013686",
        "42002221",
        "41968289",
        "41963179",
        "41947665",
        "41817153",
        "41804951",
        "41790247",
        "41758223",
        "41691708",
        "41558805",
        "41429013",
        "41319841",
        "41247288",
        "41111092",
        "40977395",
        "40132108",
        "39964582"
      ],
      "http": 200
    },
    {
      "topic": "mortality-safety",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (suicid* OR mortality OR safety OR \"adverse effect\" OR mania OR overdose) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"suicid*\"[All Fields] OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading]) OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]) OR \"adverse effect\"[All Fields] OR (\"mania\"[MeSH Terms] OR \"mania\"[All Fields] OR \"manias\"[All Fields]) OR (\"drug overdose\"[MeSH Terms] OR (\"drug\"[All Fields] AND \"overdose\"[All Fields]) OR \"drug overdose\"[All Fields] OR \"overdose\"[All Fields] OR \"overdoses\"[All Fields] OR \"overdosed\"[All Fields] OR \"overdosing\"[All Fields])) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "guidelines",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (guideline[pt] OR practice guideline[pt] OR consensus OR recommendation*) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR \"recommendation*\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 27,
      "ids": [
        "28520380",
        "42854791",
        "42832766",
        "42814927",
        "42801835",
        "42797527",
        "42789363",
        "42788073",
        "42783499",
        "42766019",
        "42756688",
        "42745306",
        "30725910",
        "42696738",
        "42658152",
        "42572938",
        "42533130",
        "42518156",
        "42411994",
        "42410139",
        "42314447",
        "42105580",
        "42092400",
        "42035799",
        "42020763",
        "41513565",
        "41500406"
      ],
      "http": 200
    },
    {
      "topic": "guidelines",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (guideline[pt] OR practice guideline[pt] OR consensus OR recommendation*) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"guideline\"[Publication Type] OR \"practice guideline\"[Publication Type] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR \"recommendation*\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "patient-experience",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (\"lived experience\" OR \"patient perspective\" OR \"patient reported\" OR stigma OR \"shared decision\" OR \"treatment burden\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"lived experience\"[All Fields] OR \"patient perspective\"[All Fields] OR \"patient reported\"[All Fields] OR (\"social stigma\"[MeSH Terms] OR (\"social\"[All Fields] AND \"stigma\"[All Fields]) OR \"social stigma\"[All Fields] OR \"stigma\"[All Fields] OR \"stigmas\"[All Fields] OR \"stigma s\"[All Fields]) OR \"shared decision\"[All Fields] OR \"treatment burden\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 36,
      "ids": [
        "42901970",
        "42901397",
        "42901213",
        "42898229",
        "42879916",
        "42878501",
        "42878230",
        "42842074",
        "42832644",
        "42830726",
        "42811249",
        "42799722",
        "42799462",
        "42778211",
        "42767626",
        "42766849",
        "42766497",
        "42756839",
        "42748866",
        "42742617",
        "30855854",
        "42725261",
        "42716055",
        "42710412",
        "42701687",
        "42701679",
        "42693223",
        "42684674",
        "42663608",
        "42610207",
        "42558024",
        "42475069",
        "42119185",
        "42070122",
        "41817153",
        "40935332"
      ],
      "http": 200
    },
    {
      "topic": "patient-experience",
      "cochrane": true,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (\"lived experience\" OR \"patient perspective\" OR \"patient reported\" OR stigma OR \"shared decision\" OR \"treatment burden\") AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication]) AND \"Cochrane Database Syst Rev\"[jour]",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND (\"lived experience\"[All Fields] OR \"patient perspective\"[All Fields] OR \"patient reported\"[All Fields] OR (\"social stigma\"[MeSH Terms] OR (\"social\"[All Fields] AND \"stigma\"[All Fields]) OR \"social stigma\"[All Fields] OR \"stigma\"[All Fields] OR \"stigmas\"[All Fields] OR \"stigma s\"[All Fields]) OR \"shared decision\"[All Fields] OR \"treatment burden\"[All Fields]) AND 2026/08/28:2026/10/22[Date - Publication] AND \"Cochrane Database Syst Rev\"[Journal]",
      "count": 0,
      "ids": [],
      "http": 200
    },
    {
      "topic": "broad-depression-CDSR",
      "cochrane": true,
      "query": "depress* AND \"Cochrane Database Syst Rev\"[jour] AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "translation": "\"depress*\"[All Fields] AND \"Cochrane Database Syst Rev\"[Journal] AND 2026/08/28:2026/10/22[Date - Publication]",
      "count": 3,
      "ids": [
        "42861686",
        "42680183",
        "42663176"
      ],
      "http": 200
    },
    {
      "topic": "cdsr-depression-2026-catchup",
      "cochrane": true,
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (depress* OR antidepressant*) AND 2026:2026[dp]",
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"depress*\"[All Fields] OR \"antidepressant*\"[All Fields]) AND 2026/01/01:2026/12/31[Date - Publication]",
      "count": 14,
      "ids": [
        "42863850",
        "42861686",
        "42680183",
        "42663176",
        "42644645",
        "42339755",
        "42206608",
        "42138335",
        "42117563",
        "42011808",
        "41700575",
        "41636687",
        "41542871",
        "41500513"
      ],
      "http": 200
    },
    {
      "topic": "edat-since-last-sweep",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (\"2026/10/16\"[Date - Entrez] : \"2026/10/22\"[Date - Entrez])",
      "translation": "(\"major depression\"[Title/Abstract] OR \"major depressive\"[Title/Abstract] OR \"unipolar depression\"[Title/Abstract]) AND 2026/10/16:2026/10/22[Date - Entry]",
      "count": 56,
      "ids": [
        "42902279",
        "42902270",
        "42901970",
        "42901399",
        "42901397",
        "42901213",
        "42899015",
        "42898691",
        "42898229",
        "42897683",
        "42897264",
        "42897167",
        "42896686",
        "42896406",
        "42896217",
        "42896175",
        "42895746",
        "42895100",
        "42894926",
        "42894373",
        "42894304",
        "42894301",
        "42894300",
        "42893994",
        "28520380",
        "42893748",
        "42892769",
        "42892401",
        "42892400",
        "42892399",
        "42892100",
        "42892099",
        "42892095",
        "42892069",
        "42891334",
        "42891241",
        "42891141",
        "42890752",
        "42890690",
        "42889347",
        "42889292",
        "42889194",
        "42888351",
        "42887784",
        "42887658",
        "42887530",
        "42887092",
        "42886804",
        "42886483",
        "42886211",
        "42885695",
        "42885693",
        "42884380",
        "42884023",
        "42883782",
        "42883713"
      ],
      "http": 200
    },
    {
      "topic": "retraction-window",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depression\"[tiab] OR \"major depressive\"[tiab] OR \"unipolar depression\"[tiab]) AND (retracted publication[pt] OR \"Expression of Concern\"[pt] OR \"Retraction of Publication\"[pt]) AND (\"2026/08/28\"[Date - Publication] : \"2026/10/22\"[Date - Publication])",
      "count": 0,
      "ids": [],
      "http": 200,
      "translation_note": "First unquoted attempt errored on phrasesnotfound publication. This quoted rerun returned count 0."
    },
    {
      "topic": "retracted-publication-mdd-2026",
      "cochrane": false,
      "query": "(\"Depressive Disorder, Major\"[Mesh] OR \"major depressive\"[tiab]) AND (retracted publication[pt] OR \"Retraction of Publication\"[pt]) AND 2026:2026[dp]",
      "count": 1,
      "ids": [
        "42656927"
      ],
      "http": 200,
      "note": "Outside the strict 2026-08-28 window. Not added. Not previously cited in this condition."
    }
  ],
  "europe_pmc": [
    {
      "topic": "diagnosis",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (diagnos* OR heterogeneity OR phenotype* OR screening OR \"mixed features\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 444,
      "fetched": 444,
      "medline_count": 333,
      "pmids": [
        "42758600",
        "42725756",
        "42670435",
        "42688594",
        "42737920",
        "42721164",
        "42883713",
        "42737858",
        "42815877",
        "42812643",
        "42815730",
        "42688891",
        "42699697",
        "42829941",
        "42783499",
        "42819210",
        "42756176",
        "42760730",
        "42839001",
        "42732880",
        "42769949",
        "42707709",
        "42871390",
        "42702010",
        "42736349",
        "42807528",
        "42686088",
        "42698177",
        "42894373",
        "42895100",
        "42774912",
        "42796411",
        "42684694",
        "42550483",
        "42797527",
        "42804067",
        "42771084",
        "42766673",
        "42756843",
        "42803524",
        "42745834",
        "42749683",
        "42812942",
        "42721198",
        "42773889",
        "42807520",
        "42760705",
        "42792438",
        "42729906",
        "42826767",
        "42735276",
        "42755741",
        "42700486",
        "42884023",
        "42748805",
        "42889194",
        "42670051",
        "42630054",
        "42696738",
        "42795740",
        "42762770",
        "42879530",
        "42696128",
        "42739877",
        "42616023",
        "42792450",
        "42729560",
        "42729848",
        "42811409",
        "42702788",
        "42704208",
        "42813034",
        "42675468",
        "42752169",
        "42901397",
        "42711407",
        "42890752",
        "42679601",
        "42728740",
        "42767040",
        "42707775",
        "42841689",
        "42863253",
        "42779163",
        "42744142",
        "42676104",
        "42710732",
        "42766497",
        "42769103",
        "42716345",
        "42751846",
        "42796071",
        "42880603",
        "42710528",
        "42685988",
        "42799462",
        "42861312",
        "42689366",
        "42758324",
        "42745799",
        "42828817",
        "42829528",
        "42806848",
        "42358003",
        "42869999",
        "42667366",
        "42698280",
        "42875717",
        "42765387",
        "42794499",
        "42840883",
        "42799588",
        "42794622",
        "42710718",
        "42701679",
        "42598999",
        "42413809",
        "42807040",
        "42783367",
        "42763338",
        "42748866",
        "42752567",
        "42753254",
        "42668924",
        "42674299",
        "42830939",
        "42735274",
        "42757108",
        "42826634",
        "42832644",
        "42872469",
        "42784817",
        "42778763",
        "41880255",
        "42681589",
        "42680855",
        "42765208",
        "42771073",
        "42833865",
        "42765605",
        "42736557",
        "42474069",
        "42805662",
        "42894926",
        "42688558",
        "42695028",
        "42885693",
        "42700488",
        "42670957",
        "42739724",
        "42789363",
        "42765861",
        "42723086",
        "42891141",
        "42883782",
        "42901970",
        "42734915",
        "42751051",
        "42723246",
        "42873880",
        "42820260",
        "42794424",
        "42777239",
        "42837085",
        "42834754",
        "42726702",
        "42767042",
        "42858131",
        "42887784",
        "42819418",
        "42688822",
        "42682977",
        "42722619",
        "42710021",
        "42779037",
        "42887530",
        "42668072",
        "42773517",
        "42768327",
        "42843469",
        "42733696",
        "42754771",
        "42843278",
        "42810627",
        "42731320",
        "42858466",
        "42771937",
        "42675332",
        "42775302",
        "42778211",
        "42861207",
        "42892099",
        "42706232",
        "42838387",
        "42824397",
        "42879997",
        "42812173",
        "42624134",
        "42732542",
        "42726636",
        "42896175",
        "42769575",
        "42791907",
        "42765137",
        "42767513",
        "42700777",
        "42732835",
        "42717325",
        "42785386",
        "42866549",
        "42710693",
        "42756128",
        "42769822",
        "42843279",
        "42698078",
        "42862091",
        "42674239",
        "42795930",
        "42785392",
        "42316910",
        "42709166",
        "42849015",
        "42701687",
        "42746369",
        "42729393",
        "42858520",
        "42838229",
        "42871667",
        "42785233",
        "42806365",
        "42756688",
        "42863800",
        "42769711",
        "42728072",
        "42797287",
        "42613180",
        "42873387",
        "42742582",
        "42761770",
        "42835756",
        "42831370",
        "42695158",
        "42752290",
        "42806433",
        "42879686",
        "42897264",
        "42705400",
        "42698872",
        "42766849",
        "42686075",
        "42844936",
        "42829056",
        "42848743",
        "42809578",
        "42680780",
        "42786261",
        "42785390",
        "42828816",
        "42765892",
        "42663293",
        "42850268",
        "42842414",
        "42830015",
        "42793276",
        "42888351",
        "42658027",
        "42815884",
        "42788073",
        "42846268",
        "42749161",
        "42838181",
        "42826818",
        "42727204",
        "42682166",
        "42822715",
        "42721112",
        "42866044",
        "42805955",
        "42887658",
        "42814927",
        "42679360",
        "42687377",
        "42765980",
        "42669842",
        "42770453",
        "42841964",
        "42752951",
        "42829057",
        "42815731",
        "40168143",
        "42716277",
        "42861501",
        "42867189",
        "42858455",
        "42850904",
        "42879916",
        "42669383",
        "41247288",
        "42756839",
        "42814113",
        "42726936",
        "42811249",
        "42880597",
        "42716347",
        "42872182",
        "42858801",
        "42679763",
        "42748377",
        "42892069",
        "32644424",
        "42833406",
        "42779162",
        "42895746",
        "42686352",
        "42691037",
        "42713675",
        "42724084",
        "42379141",
        "42799620",
        "42792385",
        "42770597",
        "42849853",
        "42891241",
        "42805590",
        "42787626",
        "42692098",
        "42778028",
        "42761292",
        "42872493",
        "42802390",
        "42803346",
        "42684674",
        "42804205"
      ],
      "non_medline": [
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PMC13444738",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depressive disorders related to Post-traumatic cases in Geriatic Patients with traumatic brain Injuries",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444423",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depressive disorders related to Post-traumatic cases after cervical spine injuries in amateur athletes",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442657",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Association Between Childhood Neglect and Major Depressive Disorder: A Systematic Review, Meta-Analysis and Meta-Regression",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442470",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "An algorithmic approach in cases of dual diagnosis - gaming disorder and major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443874",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy and Safety of Triple Monoamine Reuptake Inhibitors for Major Depressive Disorder: Meta-analysis of Randomised Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443727",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Lithium Prescription in Unipolar Depression: Findings from a Nationwide Greek Cohort Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442215",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Predictors of Sexual Dysfunction in Unipolar Depression: A Register-Based Nested Case-Control Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444383",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Reviewing Probiotics’ effects on Major depressive disorders in older adults: a systematic analysis of randomized controlled trails",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13601905",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Metabolomic dysregulation in the association between major depressive disorder and chronic pancreatitis: a large prospective cohort study",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Nutr"
        },
        {
          "id": "PMC13674596",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": "bioRxiv"
        },
        {
          "id": "PMC13608885",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The expressions and m6A methylation modification patterns of mRNAs and lncRNAs in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Genet"
        },
        {
          "id": "PMC13445404",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Transcranial Magnetic Stimulation Efficacy and Future Directions in Major Depressive Disorder: A Comprehensive Review",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556833",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "780. Classification of Major Depressive Disorder Subtypes via Surface-based Brain Imaging and Clinical Features",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1310525",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10321561/v1",
          "title": "Perceived Parental Control and Mixed-Feature Symptoms in Student Patients with Depressive Episodes: Associations with Depressive Symptoms and Smartphone Addiction in a Multicenter Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-02",
          "journalTitle": null
        },
        {
          "id": "PMC13441813",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major Depressive Disorder and Patterns of Antidepressant Prescription in Greece: Α Pharmacoepidemiological Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13664290",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
          "pubYear": null,
          "pubType": "systematic-review; review",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PPR1310193",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.29.26361710",
          "title": "The timeline of brain aging in major depression: A prospective study from before first-onset to established illness",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PMC13442395",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Emotional Cognition in Major Depressive, Bipolar and Borderline Personality Disorder - a Comparative Study of Recognition of Emotion in Auditory and Visual Stimuli",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442465",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "What Outcomes Matter in Recovery in Depression?: Cross-sectional Sample of Individuals with Major Depressive Disorder in a Diverse, Safety-net Setting",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443595",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Non-communicable disease risk factors in patients with major depressive disorders",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13680482",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Spatiotemporal feature-based investigation of major depressive disorder and emotion recognition using functional near infrared spectroscopy",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-21",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13442667",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Illness course variables as predictors of efficacy and speed of response to Spravaro in major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13643535",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Machine learning classification of fNIRS signals in patients with major depressive disorder and healthy controls",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-08",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13556582",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "249. A head-to-head comparison of two biologically-based subtyping solutions for major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556773",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "306. Genetic and neuroimaging correlates of symptom severity in major depressive disorder: an imaging–genetics study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13442032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy of Probiotic Supplementation with Lactobacillus and Bifidobacterium in Major Depressive Disorder: A Meta-analysis of Randomized Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444688",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Predictive value of C-reactive Protein for antidepressant treatment response in patients with major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1323246",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/u72y4_v1",
          "title": "Genetic Evidence Linking Prefrontal Surface Area to ADHD, Major Depression, and Smoking Initiation",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-20",
          "journalTitle": null
        },
        {
          "id": "PMC13661943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13443547",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The efficacy of transcranial direct current stimulation (tDCS) combined with cognitive behavioural therapy for major depressive disorder: a systematic review and meta-analysis of randomised controlled trials.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443003",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effectiveness of Cognitive Remediation in Subjects with Major Depressive Disorder: 3-Month Follow-Up Results of a Multicenter Randomized Controlled Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441991",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Genome-Wide DNA Methylation Analysis Reveals Epigenetic Signatures of Early Life Stress in Major Depressive Disorder Patients",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556752",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "816. Frontal structural network vulnerability and peripheral immune dysregulation in major depressive disorder: diagnostic and prognostic implications",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556682",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "487. Genome-wide DNA methylation analysis reveals epigenetic signatures of early life stress in major depressive disorder patients",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1335135",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/8wtqx_v4",
          "title": "Empirically derived phenotypes can reduce diagnostic heterogeneity",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-06",
          "journalTitle": null
        },
        {
          "id": "PMC13443665",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Endogenous Lithium Status in Major Depression: A Retrospective Analysis of EDTA Blood Samples",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441644",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Bidirectional Associations Between Highly Processed Food Consumption and Major Depressive Disorder: A Cross-Sectional Study on Adults Residing in Madrid and Barcelona (Edad con Salud)",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1327123",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/8wtqx_v3",
          "title": "Empirically derived phenotypes can reduce diagnostic heterogeneity",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-24",
          "journalTitle": null
        },
        {
          "id": "PMC13442409",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Patient and Family Determinants of Caregiver Burden in Major Depressive Disorder: A Multicenter Observational Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1333312",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.28.754910",
          "title": "Temporal organization of shared brain states characterizes heterogeneity in major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-02",
          "journalTitle": null
        },
        {
          "id": "PMC13444869",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Breaking Barriers: Exploring New Treatment Approaches for Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442464",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Case Report of an Adolescent with Major Depressive Disorder and Recurrent Suicide Attempts",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442246",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Prediction of the onset of mood disorders in the offspring of parents with bipolar and major depressive disorders",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442562",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The Neurobiology of Dual Diagnosis: Investigating the Shared Pathophysiology of Alcohol Use Disorder and Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441736",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Clinical Characteristics of Major Depressive Disorder in Children: Experience from the Child Psychiatry Department of Casablanca University",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442414",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Mind the gap: representation and outcomes of individuals with schizophrenia or major depressive disorder not eligible for randomized controlled trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556705",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "489. Task-based fMRI investigation of neural changes following acceptance and commitment therapy in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13443858",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "GLP-1 Agonist As Adjunct To Antidepressants In Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556358",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "587. Female-specific role of interleukin 6 and C-reactive protein in individuals with major depressive disorder and comorbid obesity",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556626",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "365. Association between CYP2D6 genotype and treatment outcomes in hospitalized patients with major depressive disorder: a retrospective cohort study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13444618",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Impact of Remote Patient Monitoring On Major Depressive episode And Bipolar Disorder Treatment Outcomes: EC-102 Randomized Controlled Trial",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445104",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Exploring the association between cognitive performances, early life traumas, and lifetime suicide attempts in Major Depressive Disorder: an analysis of the PROMPT study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556688",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "436. Distinct neural correlates between suicide attempters with major depressive disorder and other psychiatric disorders: a multimodal imaging study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556740",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "214. Magnetic seizure therapy for major depressive disorder: clinical efficacy, safety, and prefrontal activation measured by functional near-infrared spectroscopy",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13445383",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Polygenic risk indices for schizophrenia, bipolar and major depressive disorder associated with addiction (smoking and alcohol) in the Russian population in patients with schizophrenia or schizophrenia spectrum disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556477",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "290. Plasma neurofilament light chain levels in drug-free patients with major depressive disorder and changes after antidepressant treatment: a longitudinal pilot study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13442284",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy and Safety of Adjunctive Lumateperone 42 mg in Major Depressive Disorder: A Pooled Analysis of Demographic and Clinical Subgroups from 2 Phase 3 Randomized Placebo-Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556380",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "193. Efficacy and safety of adjunctive lumateperone 42 mg in major depressive disorder: pooled analysis of demographic and clinical subgroups from Phase 3 randomized placebo-controlled trials",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1346357",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.18.26365862",
          "title": "Shared Social Brain Gray Matter Reductions in Depression, Schizophrenia, and Alcohol Use Disorder: A Meta-Analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-20",
          "journalTitle": null
        },
        {
          "id": "PPR1313962",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.02.26362049",
          "title": "Genetic and epigenetic architecture of mass spectrometry-derived lipids in blood and their role in lifetime Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-06",
          "journalTitle": null
        },
        {
          "id": "PMC13442185",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Electroconvulsive Therapy in a Patient with Somatic Symptom Disorder and Major Depression: A Case Report",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441626",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Postoperative Catatonia in a Patient with Major Depression: A Case Report Following Orthognathic Surgery",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444050",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depression and glucidic metabolism: a prospective assessment of response to treatment with antidepressant drugs",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441862",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "What routine mental healthcare data could be used to predict response in major depression treatment?",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1330586",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.28.26364187",
          "title": "Cortical hemodynamic dysregulation is linked to peripheral NIMETOX pathways in major depressive disorder: an 89-channel fNIRS systems-biology study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PPR1337537",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-11109337/v1",
          "title": "Self-Organizing Immune-Inflammatory Architectures in Severe Major Depression: Higher- Order Interactivity and Viral Pathogenesis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-09",
          "journalTitle": null
        },
        {
          "id": "PMC13445032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Association between blood concentration of sertraline and its effectiveness and safety in major depression: exploratory results of the PREDEP-SERT study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1337148",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.06.26364737",
          "title": "Psychiatric comorbidity in dissociative identity disorder: A meta-analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-07",
          "journalTitle": null
        },
        {
          "id": "PPR1313556",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-9885081/v1",
          "title": "Adolescent subthreshold depression: Prevalence, risk factors, and transition to major depressive disorder: A systematic review and meta-analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-07",
          "journalTitle": null
        },
        {
          "id": "PPR1312842",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.29.748003",
          "title": "Postmortem Alterations of Metabotropic Glutamate Receptors across Neuropsychiatric Disorders: A Systematic Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        },
        {
          "id": "PPR1342587",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.11.26365268",
          "title": "Reduced Systemic Homeostatic and Endothelial Protective Capacity in Adolescent Major Depression: Associations with Early-Life Adversity and Clinical Phenotypes",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-13",
          "journalTitle": null
        },
        {
          "id": "PPR1340721",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-8177826/v1",
          "title": "Cellular senescence changes and their association with brain structure in schizophrenia and major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-14",
          "journalTitle": null
        },
        {
          "id": "PPR1322092",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10858262/v1",
          "title": "Symptom-level associations of immuno-metabolic indices in major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-18",
          "journalTitle": null
        },
        {
          "id": "PPR1331786",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.28.26364141",
          "title": "Transdiagnostic metabolic architecture across major depressive disorder and schizophrenia: a NIMETOX systems-biology approach",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PPR1310996",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.28.26361493",
          "title": "<i>In Vitro</i>  Ketamine Attenuates Immune Sensitization in Major Depressive Disorder in a Concentration-Dependent Manner",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-02",
          "journalTitle": null
        },
        {
          "id": "PPR1341989",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/kzsmp_v1",
          "title": "Effects of a Web-Based Debiasing Intervention on Brazilian Psychologists’ Accuracy on Major Depressive Disorder Diagnostic Tasks: A Randomized Training Intervention",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-12",
          "journalTitle": null
        },
        {
          "id": "PPR1315605",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-9633682/v1",
          "title": "Case Report: Grade 2 oligodendroglioma presenting as treatment resistant major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-09",
          "journalTitle": null
        },
        {
          "id": "PPR1328587",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.25.26363706",
          "title": "A founder population reveals genetic variation with major effect on serious mental illness",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-27",
          "journalTitle": null
        },
        {
          "id": "PPR1323803",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10628442/v1",
          "title": "Multi-Feature 3D Deep Learning for Predicting Antidepressant Treatment Response from Structural MRI",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-21",
          "journalTitle": null
        },
        {
          "id": "PPR1345206",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.16.26365761",
          "title": "The stuff that dreams are made of: Genomics and biology of nightmares",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-19",
          "journalTitle": null
        },
        {
          "id": "PPR1335719",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-11053638/v1",
          "title": "Mood Disorder Risk After Pregnancy: A Comparison of Gestational and Pregestational Diabetes",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-07",
          "journalTitle": null
        },
        {
          "id": "PPR1312767",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.31.26361809",
          "title": "Molecular Underpinnings of Retinal Traits Shared with Major Psychiatric Disorders",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        },
        {
          "id": "PPR1319526",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10822676/v1",
          "title": "Altered Serum Lipid and Amino Acid Metabolism in First-Episode Treatment-Naïve Major Depressive Disorder: A UHPLC-Q-TOF-MS Metabolomics Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-15",
          "journalTitle": null
        },
        {
          "id": "PPR1344134",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.12.26365369",
          "title": "Attenuated GlycoRNA-microglial transcriptional coupling in the dorsolateral prefrontal cortex of patients with major depressive disorder: an exploratory interaction-based in-silico analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": null
        },
        {
          "id": "PPR1318126",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362224",
          "title": "Parsing the Functional Heterogeneity of the Psychosis Spectrum: A Clinically Informed Application of Genomic Structural Equation Modeling",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-11",
          "journalTitle": null
        },
        {
          "id": "PPR1339601",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.1127.v1",
          "title": "What Epidemiological Studies Tell Us About Depression Among Black Populations?",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-13",
          "journalTitle": null
        },
        {
          "id": "PPR1328258",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.18.752576",
          "title": "Major depressive disorder recurrence and medication status shape brain network topology",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-24",
          "journalTitle": null
        },
        {
          "id": "PPR1346384",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.18.26365736",
          "title": "Dysfunctional Sleep Beliefs and Attitudes in Major Depressive Disorder: Dimensional Associations with Clinical Phenotypes and Gut-Neuroimmune-Metabolic-Oxidative Pathways",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-20",
          "journalTitle": null
        },
        {
          "id": "PPR1336428",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.0247.v1",
          "title": "Neurobiological Mechanisms of Mental Disorders in Relation to Epilepsy: A Narrative Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-05",
          "journalTitle": null
        },
        {
          "id": "PPR1317194",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10823532/v1",
          "title": "Automatic detection of depression in clinical interviews with large language models",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-11",
          "journalTitle": null
        },
        {
          "id": "PPR1342759",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.10.26365209",
          "title": "Longitudinal Pain Profiles and Their Clinical and Genetic Correlates in 624,996 U.S. Veterans",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-12",
          "journalTitle": null
        },
        {
          "id": "PPR1339657",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.1070.v1",
          "title": "Does Depression Phenotype Predict Antidepressant Response? A Transdiagnostic Review of Phenotype-Specific Antidepressant Efficacy",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-12",
          "journalTitle": null
        },
        {
          "id": "PPR1320038",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.13.26362400",
          "title": "Cumulative Indicators of Circadian Rhythm Disturbance and its Clinical, Functional and Genetic Correlates in the Brisbane Longitudinal Twin Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-14",
          "journalTitle": null
        },
        {
          "id": "PPR1344289",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.15.26365624",
          "title": "A clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of psychiatric disorders",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": null
        },
        {
          "id": "PPR1323328",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.18.26363360",
          "title": "Low-Intensity Focused Ultrasound of the Amygdala in Depression and Anxiety: A First-in-Human Active-Controlled Trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-20",
          "journalTitle": null
        },
        {
          "id": "PPR1343271",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.14.759202",
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": null
        },
        {
          "id": "PPR1319853",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10779463/v1",
          "title": "Disrupted brain network connectivity associated with the endogenous risk trait of impulsivity in depressive disorder: A network-based statistic study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-15",
          "journalTitle": null
        },
        {
          "id": "PPR1344690",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.1646.v1",
          "title": "The Role of Cortisol in CNS Disease –11β-HSD1 Inhibition as a Potential New Therapeutic Strategy for Alzheimer’s Disease and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": null
        },
        {
          "id": "PPR1343736",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10095364/v1",
          "title": "PCA-MR - A powerful framework for cis-Mendelian Randomization with correlated variants and sparse exposures",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": null
        },
        {
          "id": "PPR1307554",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10811698/v1",
          "title": "A Multilevel Mechanistic Platform for Antidepressant-Response Prediction Integrating Pharmacokinetics, Polypharmacology, Inflammation, Neuroplasticity, Large-Scale Networks and the Gut–Brain Axis: Chronological Development and Indicator-Level Evaluation Across 51 Drugs and 15 Drug–Nutraceutical Combinations",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-28",
          "journalTitle": null
        },
        {
          "id": "PPR1332815",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/m24gs_v1",
          "title": "Psychiatric Overdiagnosis as Diagnostic Stretching in Response to Clinical Need",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-02",
          "journalTitle": null
        },
        {
          "id": "PPR1332876",
          "source": "PPR",
          "pmid": null,
          "doi": "10.14293/pr2199.004576.v1",
          "title": "Voided REM Sleep (V-REM)",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-28",
          "journalTitle": null
        },
        {
          "id": "PPR1310523",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10739557/v1",
          "title": "Mitochondrial dysfunction in first-episode drug-naïve major depressive disorder: insights from serum non-targeted metabolomics",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-02",
          "journalTitle": null
        },
        {
          "id": "PPR1341863",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/cepxv_v1",
          "title": "Rumination under the microscope: causal discovery and inference of the effect of rumination on depressive symptoms in an N-of-1 time series",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-14",
          "journalTitle": null
        },
        {
          "id": "PPR1312534",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/c3qbj_v1",
          "title": "Longitudinal computational phenotyping reveals a stable marker for depression symptoms",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": null
        },
        {
          "id": "PPR1328368",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.24.26363889",
          "title": "Directed effective connectivity between the SCN-containing hypothalamus and pineal gland varies by chronotype in bipolar disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-26",
          "journalTitle": null
        },
        {
          "id": "PPR1343552",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-11088167/v1",
          "title": "Striatal tissue iron in depressed and healthy individuals and the effect of buproprion",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": null
        },
        {
          "id": "PPR1324601",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10327913/v1",
          "title": "Treatment Resistant Depression: Perspective of Psychiatrists in Saudi Arabia",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-22",
          "journalTitle": null
        },
        {
          "id": "PPR1320383",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10638348/v1",
          "title": "Neutrophil-related inflammatory activation during medication-overdose suicide attempts in depressive patients: a case-control study with within-subject pre-attempt comparison",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-16",
          "journalTitle": null
        },
        {
          "id": "PPR1332977",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.27.754773",
          "title": "Alignment with sex-typical brain architecture: Links to mood pathology, sex hormones and transcriptomics of neurodegenerative conditions",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-02",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "burden",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (epidemiology OR prevalence OR incidence OR \"global burden\" OR \"treatment gap\" OR registry) AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 210,
      "fetched": 210,
      "medline_count": 170,
      "pmids": [
        "42688594",
        "42765137",
        "42819210",
        "42837085",
        "42758600",
        "42812643",
        "42850268",
        "42681589",
        "42663608",
        "42812942",
        "42735274",
        "42358003",
        "42879916",
        "42779163",
        "42474069",
        "42795740",
        "42858455",
        "42760730",
        "42737858",
        "42698280",
        "42688558",
        "42820260",
        "42815877",
        "42787408",
        "42850904",
        "42771084",
        "42766849",
        "42817096",
        "42713675",
        "42758324",
        "42696738",
        "42710693",
        "42862569",
        "42670435",
        "42894373",
        "42749881",
        "42799462",
        "42858466",
        "42701679",
        "42731320",
        "42670051",
        "42757108",
        "42701687",
        "42700488",
        "42767626",
        "42785386",
        "42739877",
        "42756128",
        "42794622",
        "42695028",
        "42866493",
        "42675332",
        "42779162",
        "42721198",
        "42829528",
        "42715127",
        "42744145",
        "42707709",
        "42745834",
        "42797527",
        "42802397",
        "42843279",
        "42836998",
        "42858520",
        "42752567",
        "42729906",
        "42727204",
        "42756843",
        "42826766",
        "42733696",
        "42688822",
        "42890752",
        "42844936",
        "42722435",
        "42841964",
        "42765208",
        "42867189",
        "42803904",
        "41247288",
        "42807528",
        "42799588",
        "42789363",
        "42795930",
        "42858801",
        "42792438",
        "42705027",
        "42714093",
        "42699697",
        "42679601",
        "42778028",
        "42716277",
        "42766673",
        "42887092",
        "42686075",
        "42598999",
        "42840883",
        "42802390",
        "42705400",
        "42726702",
        "42861501",
        "42584886",
        "42680114",
        "42679360",
        "42756176",
        "42828816",
        "42819418",
        "42886483",
        "42769103",
        "42751051",
        "42731592",
        "42682977",
        "42809770",
        "42658027",
        "42698872",
        "32644424",
        "42616023",
        "42756839",
        "42630054",
        "42739724",
        "42803346",
        "42784817",
        "42754771",
        "42742582",
        "42761770",
        "42695158",
        "42663293",
        "42891241",
        "42710021",
        "42729848",
        "42684674",
        "42748377",
        "42896217",
        "42838229",
        "42717325",
        "42734915",
        "42805662",
        "42796411",
        "42901213",
        "42884023",
        "42792450",
        "42796071",
        "42768327",
        "42842414",
        "42872125",
        "42687377",
        "42729560",
        "42807520",
        "42682166",
        "42815884",
        "42783499",
        "42769711",
        "42668924",
        "42804205",
        "42691037",
        "42778763",
        "42791907",
        "42895746",
        "42769822",
        "42686352",
        "42760705",
        "42756688",
        "42728740",
        "42698078",
        "42706232",
        "42830939",
        "42613180",
        "42794424",
        "42775302",
        "42783367",
        "42746369"
      ],
      "non_medline": [
        {
          "id": "PMC13601905",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Metabolomic dysregulation in the association between major depressive disorder and chronic pancreatitis: a large prospective cohort study",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Nutr"
        },
        {
          "id": "PMC13443727",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Lithium Prescription in Unipolar Depression: Findings from a Nationwide Greek Cohort Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442470",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "An algorithmic approach in cases of dual diagnosis - gaming disorder and major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556477",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "290. Plasma neurofilament light chain levels in drug-free patients with major depressive disorder and changes after antidepressant treatment: a longitudinal pilot study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13443874",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy and Safety of Triple Monoamine Reuptake Inhibitors for Major Depressive Disorder: Meta-analysis of Randomised Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443665",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Endogenous Lithium Status in Major Depression: A Retrospective Analysis of EDTA Blood Samples",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13661943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PPR1344460",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10141103/v1",
          "title": "Internet Addiction and Non-Suicidal Self-Injury in Adolescents with Major Depressive Disorder: The Sequential Mediating Roles of Insomnia and Depressive Symptoms",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-18",
          "journalTitle": null
        },
        {
          "id": "PMC13442246",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Prediction of the onset of mood disorders in the offspring of parents with bipolar and major depressive disorders",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441813",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major Depressive Disorder and Patterns of Antidepressant Prescription in Greece: Α Pharmacoepidemiological Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1313556",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-9885081/v1",
          "title": "Adolescent subthreshold depression: Prevalence, risk factors, and transition to major depressive disorder: A systematic review and meta-analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-07",
          "journalTitle": null
        },
        {
          "id": "PMC13444738",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depressive disorders related to Post-traumatic cases in Geriatic Patients with traumatic brain Injuries",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556810",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "439. Polygenic stratification reveals differential response to V1b antagonism in pre-exposed patients with major depressive disorder: a post-hoc analysis of the phase 2 OLIVE trial",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13444423",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depressive disorders related to Post-traumatic cases after cervical spine injuries in amateur athletes",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1310193",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.29.26361710",
          "title": "The timeline of brain aging in major depression: A prospective study from before first-onset to established illness",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PMC13442562",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The Neurobiology of Dual Diagnosis: Investigating the Shared Pathophysiology of Alcohol Use Disorder and Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442465",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "What Outcomes Matter in Recovery in Depression?: Cross-sectional Sample of Individuals with Major Depressive Disorder in a Diverse, Safety-net Setting",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444869",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Breaking Barriers: Exploring New Treatment Approaches for Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PMC13442931",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effect Of Cariprazine On Metabolic Parameters In Patients Living With Major Depressive Disorder: A Systematic Review And Meta-Analysis",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13674596",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": "bioRxiv"
        },
        {
          "id": "PMC13608885",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The expressions and m6A methylation modification patterns of mRNAs and lncRNAs in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Genet"
        },
        {
          "id": "PMC13442395",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Emotional Cognition in Major Depressive, Bipolar and Borderline Personality Disorder - a Comparative Study of Recognition of Emotion in Auditory and Visual Stimuli",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556678",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "602. Neurobiological subtyping of major depression identifies distinct cardiometabolic risk profiles in UK Biobank",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13443003",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effectiveness of Cognitive Remediation in Subjects with Major Depressive Disorder: 3-Month Follow-Up Results of a Multicenter Randomized Controlled Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13680482",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Spatiotemporal feature-based investigation of major depressive disorder and emotion recognition using functional near infrared spectroscopy",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-21",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13664290",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
          "pubYear": null,
          "pubType": "systematic-review; review",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13442185",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Electroconvulsive Therapy in a Patient with Somatic Symptom Disorder and Major Depression: A Case Report",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Association between blood concentration of sertraline and its effectiveness and safety in major depression: exploratory results of the PREDEP-SERT study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1308902",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.25.26361081",
          "title": "Adjunctive Psychobiotic  <i>Lactiplantibacillus plantarum</i>  PS128 Therapy and Escitalopram in Major Depressive Disorder: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PPR1338064",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.07.26364957",
          "title": "Sustained Viral Suppression and its association with Psychiatric Morbidity and Sleep Quality among Older Adults with Human Immunodeficiency Virus: Evidence from a Retrospective Cohort in Ibadan, Nigeria.",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-09",
          "journalTitle": null
        },
        {
          "id": "PPR1317770",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362462",
          "title": "Effects of sex, treatment resistance, and antidepressant treatment on monoamine oxidase B total distribution volume",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-10",
          "journalTitle": null
        },
        {
          "id": "PPR1313962",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.02.26362049",
          "title": "Genetic and epigenetic architecture of mass spectrometry-derived lipids in blood and their role in lifetime Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-06",
          "journalTitle": null
        },
        {
          "id": "PPR1337148",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.06.26364737",
          "title": "Psychiatric comorbidity in dissociative identity disorder: A meta-analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-07",
          "journalTitle": null
        },
        {
          "id": "PPR1345217",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.16.26364574",
          "title": "Identification of pleiotropic genes and biological mechanisms underlying the shared genetic component between asthma, neuropsychiatric disorders, and substance use behaviors",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-19",
          "journalTitle": null
        },
        {
          "id": "PPR1317728",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362466",
          "title": "Lifestyle therapy versus cognitive behavioural therapy for adults with mood disorders: a randomised non-inferiority trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-10",
          "journalTitle": null
        },
        {
          "id": "PPR1328258",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.18.752576",
          "title": "Major depressive disorder recurrence and medication status shape brain network topology",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-24",
          "journalTitle": null
        },
        {
          "id": "PPR1320038",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.13.26362400",
          "title": "Cumulative Indicators of Circadian Rhythm Disturbance and its Clinical, Functional and Genetic Correlates in the Brisbane Longitudinal Twin Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-14",
          "journalTitle": null
        },
        {
          "id": "PPR1324601",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10327913/v1",
          "title": "Treatment Resistant Depression: Perspective of Psychiatrists in Saudi Arabia",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-22",
          "journalTitle": null
        },
        {
          "id": "PPR1339601",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.1127.v1",
          "title": "What Epidemiological Studies Tell Us About Depression Among Black Populations?",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-13",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "mechanisms",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (neurobiolog* OR neuroinflamm* OR \"HPA axis\" OR BDNF OR \"neural circuit\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 182,
      "fetched": 182,
      "medline_count": 143,
      "pmids": [
        "42670051",
        "42707709",
        "42671502",
        "42699697",
        "42794499",
        "42883713",
        "42737858",
        "42729906",
        "42724084",
        "42729560",
        "42663293",
        "42752951",
        "42777979",
        "42707775",
        "42794424",
        "42745799",
        "42783499",
        "42893748",
        "42812942",
        "42770453",
        "42826634",
        "42710732",
        "42685988",
        "42797527",
        "42826581",
        "42616023",
        "42795740",
        "42884023",
        "42702010",
        "42753853",
        "42630054",
        "42758600",
        "42723246",
        "42829528",
        "42696458",
        "42692098",
        "42819418",
        "42860592",
        "42803524",
        "42774912",
        "42755741",
        "42879530",
        "42842414",
        "42768327",
        "42813034",
        "42792438",
        "42729848",
        "42688891",
        "42894373",
        "42756176",
        "42871390",
        "42794622",
        "42737920",
        "42732880",
        "42797287",
        "42828817",
        "42550483",
        "42723086",
        "42812173",
        "42817096",
        "42752567",
        "42598999",
        "42696738",
        "42771073",
        "42765605",
        "42733696",
        "42736557",
        "42824397",
        "42698280",
        "42799462",
        "42767040",
        "42769949",
        "42779163",
        "42745218",
        "42670435",
        "42773517",
        "42700763",
        "42895100",
        "42810627",
        "42728701",
        "42769822",
        "42771084",
        "42764140",
        "42686088",
        "42765861",
        "42735276",
        "42710718",
        "42709645",
        "42793276",
        "42766483",
        "42765387",
        "42676104",
        "42715443",
        "42769103",
        "42870751",
        "42762770",
        "42807528",
        "42704208",
        "42721112",
        "42765208",
        "42744142",
        "42795930",
        "42841964",
        "42762287",
        "42874001",
        "42675468",
        "42728740",
        "42858520",
        "42706232",
        "42688822",
        "42789363",
        "42806433",
        "42897264",
        "42734915",
        "42883782",
        "42769575",
        "42771937",
        "42702788",
        "42668072",
        "42850268",
        "42892095",
        "42763338",
        "42840883",
        "42838181",
        "42826818",
        "42807520",
        "42805955",
        "42887658",
        "42679360",
        "42731592",
        "42778763",
        "42710528",
        "42768143",
        "42809944",
        "42890752",
        "42613180",
        "42770452",
        "42799588",
        "42805590",
        "42778028",
        "42686075",
        "42775302",
        "42746369"
      ],
      "non_medline": [
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PMC13445404",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Transcranial Magnetic Stimulation Efficacy and Future Directions in Major Depressive Disorder: A Comprehensive Review",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442562",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The Neurobiology of Dual Diagnosis: Investigating the Shared Pathophysiology of Alcohol Use Disorder and Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443727",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Lithium Prescription in Unipolar Depression: Findings from a Nationwide Greek Cohort Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556810",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "439. Polygenic stratification reveals differential response to V1b antagonism in pre-exposed patients with major depressive disorder: a post-hoc analysis of the phase 2 OLIVE trial",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13443003",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effectiveness of Cognitive Remediation in Subjects with Major Depressive Disorder: 3-Month Follow-Up Results of a Multicenter Randomized Controlled Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13601905",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Metabolomic dysregulation in the association between major depressive disorder and chronic pancreatitis: a large prospective cohort study",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Nutr"
        },
        {
          "id": "PMC13443858",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "GLP-1 Agonist As Adjunct To Antidepressants In Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13608885",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The expressions and m6A methylation modification patterns of mRNAs and lncRNAs in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Genet"
        },
        {
          "id": "PMC13674596",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": "bioRxiv"
        },
        {
          "id": "PMC13443665",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Endogenous Lithium Status in Major Depression: A Retrospective Analysis of EDTA Blood Samples",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1340375",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-11194275/v1",
          "title": "Sex-dependent differences in matrix metalloproteinase-9 and inflammatory markers in postmortem brain of depressed subjects: Effect of pharmacological treatment and suicide",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-14",
          "journalTitle": null
        },
        {
          "id": "PMC13661943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PPR1341371",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-11106755/v1",
          "title": "Intranasal Human Olfactory Mucosa-Derived Neural Stem Cells Restore Neuroplasticity and Suppress Neuroinflammation in a Rat Model of Chronic Stress-Induced Depression",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-13",
          "journalTitle": null
        },
        {
          "id": "PPR1336028",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.06.26364759",
          "title": "Neuroplasticity-Based Treatment Prioritization in Major Depressive Disorder: A Two-Cohort Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-07",
          "journalTitle": null
        },
        {
          "id": "PPR1308902",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.25.26361081",
          "title": "Adjunctive Psychobiotic  <i>Lactiplantibacillus plantarum</i>  PS128 Therapy and Escitalopram in Major Depressive Disorder: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PMC13444383",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Reviewing Probiotics’ effects on Major depressive disorders in older adults: a systematic analysis of randomized controlled trails",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1342658",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.06.757042",
          "title": "Dual Roles of Interferon-γ Receptor in Somatostatin Interneurons at Baseline and During",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-13",
          "journalTitle": null
        },
        {
          "id": "PPR1323246",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/u72y4_v1",
          "title": "Genetic Evidence Linking Prefrontal Surface Area to ADHD, Major Depression, and Smoking Initiation",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-20",
          "journalTitle": null
        },
        {
          "id": "PPR1310193",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.29.26361710",
          "title": "The timeline of brain aging in major depression: A prospective study from before first-onset to established illness",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PMC13680482",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Spatiotemporal feature-based investigation of major depressive disorder and emotion recognition using functional near infrared spectroscopy",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-21",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13643535",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Machine learning classification of fNIRS signals in patients with major depressive disorder and healthy controls",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-08",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13664290",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
          "pubYear": null,
          "pubType": "systematic-review; review",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13444869",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Breaking Barriers: Exploring New Treatment Approaches for Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556582",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "249. A head-to-head comparison of two biologically-based subtyping solutions for major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13441736",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Clinical Characteristics of Major Depressive Disorder in Children: Experience from the Child Psychiatry Department of Casablanca University",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556833",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "780. Classification of Major Depressive Disorder Subtypes via Surface-based Brain Imaging and Clinical Features",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556752",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "816. Frontal structural network vulnerability and peripheral immune dysregulation in major depressive disorder: diagnostic and prognostic implications",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556705",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "489. Task-based fMRI investigation of neural changes following acceptance and commitment therapy in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556682",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "487. Genome-wide DNA methylation analysis reveals epigenetic signatures of early life stress in major depressive disorder patients",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556394",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "363. Angular gyrus as a key hub of treatment refractoriness and neuromodulation response in major depressive disorder: a data-driven structural covariance network analysis",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1307554",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10811698/v1",
          "title": "A Multilevel Mechanistic Platform for Antidepressant-Response Prediction Integrating Pharmacokinetics, Polypharmacology, Inflammation, Neuroplasticity, Large-Scale Networks and the Gut–Brain Axis: Chronological Development and Indicator-Level Evaluation Across 51 Drugs and 15 Drug–Nutraceutical Combinations",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-28",
          "journalTitle": null
        },
        {
          "id": "PMC13442185",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Electroconvulsive Therapy in a Patient with Somatic Symptom Disorder and Major Depression: A Case Report",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556549",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "252. Clinical application of psychedelic-assisted therapy in major depression and addictions",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556678",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "602. Neurobiological subtyping of major depression identifies distinct cardiometabolic risk profiles in UK Biobank",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1336428",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.0247.v1",
          "title": "Neurobiological Mechanisms of Mental Disorders in Relation to Epilepsy: A Narrative Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-05",
          "journalTitle": null
        },
        {
          "id": "PPR1328258",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.18.752576",
          "title": "Major depressive disorder recurrence and medication status shape brain network topology",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-24",
          "journalTitle": null
        },
        {
          "id": "PPR1312767",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.31.26361809",
          "title": "Molecular Underpinnings of Retinal Traits Shared with Major Psychiatric Disorders",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        },
        {
          "id": "PPR1317763",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362586",
          "title": "Brain functional dynamics linked to depression and anxiety: cross-sectional and longitudinal associations over 9 years",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-10",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "genetics",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (genetic* OR GWAS OR polygenic OR epigenetic* OR ancestry) AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 172,
      "fetched": 172,
      "medline_count": 125,
      "pmids": [
        "42773889",
        "42831370",
        "42771084",
        "42598999",
        "42894926",
        "42887784",
        "42839001",
        "42872493",
        "42861501",
        "42862091",
        "42886211",
        "42814113",
        "42706232",
        "42679763",
        "42892069",
        "42890752",
        "42760730",
        "42710693",
        "42792438",
        "42728740",
        "42836998",
        "42830219",
        "42709645",
        "42749774",
        "42858466",
        "42707775",
        "42803346",
        "42891141",
        "42807520",
        "42850268",
        "42791907",
        "42744145",
        "42813034",
        "42901213",
        "42695028",
        "42756843",
        "42693300",
        "42794499",
        "42797527",
        "42688891",
        "42702010",
        "42732880",
        "42777979",
        "42894373",
        "42879530",
        "42707709",
        "42803524",
        "42883713",
        "42729906",
        "42819418",
        "42871390",
        "42817096",
        "42745834",
        "42737858",
        "42696128",
        "42729848",
        "42630054",
        "42815877",
        "42833865",
        "42736557",
        "42682166",
        "42742582",
        "42853203",
        "42670435",
        "42895100",
        "42734915",
        "42745799",
        "42756176",
        "42670051",
        "42663293",
        "42812643",
        "42765137",
        "42765387",
        "42715443",
        "42769103",
        "42732835",
        "42785386",
        "42884023",
        "42765208",
        "42751051",
        "42794622",
        "42696738",
        "42584886",
        "42729560",
        "42829528",
        "42874001",
        "42858520",
        "42749498",
        "42812173",
        "42788145",
        "42688822",
        "42783499",
        "42779037",
        "42794424",
        "42835756",
        "42803521",
        "42806433",
        "42771937",
        "42769575",
        "42702788",
        "42795740",
        "42723246",
        "42786261",
        "42668072",
        "42842414",
        "42769822",
        "42721112",
        "42316910",
        "42100925",
        "42710732",
        "42871888",
        "42778763",
        "42768143",
        "42733696",
        "42669383",
        "42764573",
        "42876217",
        "42613180",
        "42616023",
        "42761770",
        "42668924",
        "42723086",
        "42701687",
        "42667302",
        "42775302"
      ],
      "non_medline": [
        {
          "id": "PMC13674596",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": "bioRxiv"
        },
        {
          "id": "PPR1312767",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.31.26361809",
          "title": "Molecular Underpinnings of Retinal Traits Shared with Major Psychiatric Disorders",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        },
        {
          "id": "PPR1344289",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.15.26365624",
          "title": "A clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of psychiatric disorders",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": null
        },
        {
          "id": "PPR1320038",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.13.26362400",
          "title": "Cumulative Indicators of Circadian Rhythm Disturbance and its Clinical, Functional and Genetic Correlates in the Brisbane Longitudinal Twin Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-14",
          "journalTitle": null
        },
        {
          "id": "PPR1345206",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.16.26365761",
          "title": "The stuff that dreams are made of: Genomics and biology of nightmares",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-19",
          "journalTitle": null
        },
        {
          "id": "PPR1342759",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.10.26365209",
          "title": "Longitudinal Pain Profiles and Their Clinical and Genetic Correlates in 624,996 U.S. Veterans",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-12",
          "journalTitle": null
        },
        {
          "id": "PPR1313962",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.02.26362049",
          "title": "Genetic and epigenetic architecture of mass spectrometry-derived lipids in blood and their role in lifetime Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-06",
          "journalTitle": null
        },
        {
          "id": "PMC13445383",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Polygenic risk indices for schizophrenia, bipolar and major depressive disorder associated with addiction (smoking and alcohol) in the Russian population in patients with schizophrenia or schizophrenia spectrum disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556810",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "439. Polygenic stratification reveals differential response to V1b antagonism in pre-exposed patients with major depressive disorder: a post-hoc analysis of the phase 2 OLIVE trial",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556752",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "816. Frontal structural network vulnerability and peripheral immune dysregulation in major depressive disorder: diagnostic and prognostic implications",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1347340",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.18.26365850",
          "title": "Association of neurotransmitter-based polygenic scores with antidepressant treatment outcomes in patients with major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-21",
          "journalTitle": null
        },
        {
          "id": "PMC13443727",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Lithium Prescription in Unipolar Depression: Findings from a Nationwide Greek Cohort Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556678",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "602. Neurobiological subtyping of major depression identifies distinct cardiometabolic risk profiles in UK Biobank",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1317739",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362568",
          "title": "Human genetic risk for major depressive disorder implicates motor cortex PVALB⁺ inhibitory neurons",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-10",
          "journalTitle": null
        },
        {
          "id": "PMC13442246",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Prediction of the onset of mood disorders in the offspring of parents with bipolar and major depressive disorders",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PMC13441813",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major Depressive Disorder and Patterns of Antidepressant Prescription in Greece: Α Pharmacoepidemiological Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1329344",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.18.26363409",
          "title": "Epigenetic age acceleration is associated with brain connectivity changes and the risk of major depression after trauma",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-28",
          "journalTitle": null
        },
        {
          "id": "PPR1343271",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.14.759202",
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": null
        },
        {
          "id": "PPR1345217",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.16.26364574",
          "title": "Identification of pleiotropic genes and biological mechanisms underlying the shared genetic component between asthma, neuropsychiatric disorders, and substance use behaviors",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-19",
          "journalTitle": null
        },
        {
          "id": "PMC13608885",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The expressions and m6A methylation modification patterns of mRNAs and lncRNAs in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Genet"
        },
        {
          "id": "PPR1336428",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.0247.v1",
          "title": "Neurobiological Mechanisms of Mental Disorders in Relation to Epilepsy: A Narrative Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-05",
          "journalTitle": null
        },
        {
          "id": "PMC13601905",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Metabolomic dysregulation in the association between major depressive disorder and chronic pancreatitis: a large prospective cohort study",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Nutr"
        },
        {
          "id": "PPR1329398",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.26.26364056",
          "title": "Dissecting shared genetic susceptibility between gastroesophageal reflux disease and psychiatric disorders beyond body mass index",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-28",
          "journalTitle": null
        },
        {
          "id": "PMC13442562",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The Neurobiology of Dual Diagnosis: Investigating the Shared Pathophysiology of Alcohol Use Disorder and Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441991",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Genome-Wide DNA Methylation Analysis Reveals Epigenetic Signatures of Early Life Stress in Major Depressive Disorder Patients",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556682",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "487. Genome-wide DNA methylation analysis reveals epigenetic signatures of early life stress in major depressive disorder patients",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13441644",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Bidirectional Associations Between Highly Processed Food Consumption and Major Depressive Disorder: A Cross-Sectional Study on Adults Residing in Madrid and Barcelona (Edad con Salud)",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443595",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Non-communicable disease risk factors in patients with major depressive disorders",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444869",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Breaking Barriers: Exploring New Treatment Approaches for Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442464",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Case Report of an Adolescent with Major Depressive Disorder and Recurrent Suicide Attempts",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445404",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Transcranial Magnetic Stimulation Efficacy and Future Directions in Major Depressive Disorder: A Comprehensive Review",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556773",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "306. Genetic and neuroimaging correlates of symptom severity in major depressive disorder: an imaging–genetics study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556626",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "365. Association between CYP2D6 genotype and treatment outcomes in hospitalized patients with major depressive disorder: a retrospective cohort study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1307554",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10811698/v1",
          "title": "A Multilevel Mechanistic Platform for Antidepressant-Response Prediction Integrating Pharmacokinetics, Polypharmacology, Inflammation, Neuroplasticity, Large-Scale Networks and the Gut–Brain Axis: Chronological Development and Indicator-Level Evaluation Across 51 Drugs and 15 Drug–Nutraceutical Combinations",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-28",
          "journalTitle": null
        },
        {
          "id": "PMC13442185",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Electroconvulsive Therapy in a Patient with Somatic Symptom Disorder and Major Depression: A Case Report",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Association between blood concentration of sertraline and its effectiveness and safety in major depression: exploratory results of the PREDEP-SERT study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1346357",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.18.26365862",
          "title": "Shared Social Brain Gray Matter Reductions in Depression, Schizophrenia, and Alcohol Use Disorder: A Meta-Analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-20",
          "journalTitle": null
        },
        {
          "id": "PPR1323246",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/u72y4_v1",
          "title": "Genetic Evidence Linking Prefrontal Surface Area to ADHD, Major Depression, and Smoking Initiation",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-20",
          "journalTitle": null
        },
        {
          "id": "PPR1309049",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.27.26361547",
          "title": "Epigenetic and Immunometabolic Signatures of Suicidal Behavior in Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PPR1331666",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.29.26364222",
          "title": "A rare-variant analysis of  <i>FADS</i>  -related metabolites in Major Depression",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PPR1328587",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.25.26363706",
          "title": "A founder population reveals genetic variation with major effect on serious mental illness",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-27",
          "journalTitle": null
        },
        {
          "id": "PPR1343736",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10095364/v1",
          "title": "PCA-MR - A powerful framework for cis-Mendelian Randomization with correlated variants and sparse exposures",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": null
        },
        {
          "id": "PPR1340375",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-11194275/v1",
          "title": "Sex-dependent differences in matrix metalloproteinase-9 and inflammatory markers in postmortem brain of depressed subjects: Effect of pharmacological treatment and suicide",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-14",
          "journalTitle": null
        },
        {
          "id": "PPR1338899",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.08.757516",
          "title": "Cellular and molecular census of the pleiotropic disease  <i>locus</i>  Negr1 in zebrafish",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-11",
          "journalTitle": null
        },
        {
          "id": "PPR1318126",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362224",
          "title": "Parsing the Functional Heterogeneity of the Psychosis Spectrum: A Clinically Informed Application of Genomic Structural Equation Modeling",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-11",
          "journalTitle": null
        },
        {
          "id": "PPR1311324",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.0161.v1",
          "title": "Pharmacometabolomics of Psychotropic Drugs: Treatment Response, Adverse Effects, and Precision Psychiatry—A Narrative Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-02",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "antidepressants",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (antidepressant* OR SSRI OR SNRI OR withdrawal OR discontinuation OR \"sexual dysfunction\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 269,
      "fetched": 269,
      "medline_count": 201,
      "pmids": [
        "42812643",
        "42812942",
        "42742617",
        "42682977",
        "42729393",
        "42735274",
        "42616023",
        "42829528",
        "42584886",
        "42814111",
        "42795930",
        "42739877",
        "42750362",
        "42805662",
        "42690086",
        "42756843",
        "42819210",
        "42701679",
        "42758600",
        "42663293",
        "42721164",
        "42688594",
        "42710716",
        "42756839",
        "42850904",
        "42729848",
        "42721198",
        "42745834",
        "42732880",
        "42883713",
        "42689366",
        "42687377",
        "42737920",
        "42680855",
        "42794622",
        "42797527",
        "42894926",
        "42815877",
        "42769822",
        "42550483",
        "42729184",
        "42807040",
        "42695158",
        "42894301",
        "42783499",
        "42670051",
        "42728072",
        "42795740",
        "42899015",
        "42767626",
        "42699697",
        "42736557",
        "42894373",
        "42769575",
        "42756688",
        "42769949",
        "42724084",
        "42806848",
        "42658027",
        "42794499",
        "42707709",
        "42707775",
        "42817096",
        "42752567",
        "42769711",
        "42737858",
        "42675468",
        "42688891",
        "42698872",
        "42696738",
        "42766019",
        "42766497",
        "42702010",
        "42670957",
        "42745799",
        "42769103",
        "42761770",
        "42698280",
        "42774912",
        "42789363",
        "42830939",
        "42767040",
        "42717325",
        "42901397",
        "42869167",
        "42679601",
        "42896406",
        "42779163",
        "42668390",
        "42892401",
        "42879530",
        "42734915",
        "42670435",
        "42875717",
        "42807520",
        "42705363",
        "42767564",
        "42895100",
        "42826878",
        "42729906",
        "42801835",
        "42778211",
        "42895746",
        "42861207",
        "42721112",
        "42819418",
        "42838387",
        "42892100",
        "42762641",
        "42727730",
        "42716345",
        "42413809",
        "42755741",
        "42715443",
        "28613681",
        "42715127",
        "42807528",
        "42866549",
        "42701110",
        "42763552",
        "42680119",
        "42630054",
        "42674239",
        "42751051",
        "42824397",
        "42710412",
        "30725910",
        "42784817",
        "42766673",
        "42751846",
        "42749683",
        "42812173",
        "42752587",
        "42873387",
        "42792385",
        "42858129",
        "42839386",
        "42835756",
        "42753853",
        "42684694",
        "42768327",
        "42766849",
        "42702788",
        "42680780",
        "42668072",
        "42668254",
        "42842414",
        "42722435",
        "42889347",
        "42830015",
        "42793276",
        "42696458",
        "42888351",
        "42863557",
        "42788073",
        "42838181",
        "42884023",
        "42886804",
        "42887658",
        "42814927",
        "42797287",
        "42863798",
        "42679360",
        "42841964",
        "42729560",
        "42731592",
        "42727635",
        "42871888",
        "42856566",
        "42785392",
        "42778763",
        "42684061",
        "42664168",
        "42805099",
        "42858801",
        "42379141",
        "42813034",
        "42799588",
        "42779162",
        "42777239",
        "42760705",
        "42668924",
        "42815037",
        "42732834",
        "42706232",
        "42877783",
        "42794424",
        "42786817",
        "42796071",
        "42770597",
        "42803521",
        "42692098",
        "42667302",
        "42775302",
        "42686996",
        "42799904",
        "42746369",
        "42832766",
        "42783367",
        "42901213",
        "42716055"
      ],
      "non_medline": [
        {
          "id": "PMC13556380",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "193. Efficacy and safety of adjunctive lumateperone 42 mg in major depressive disorder: pooled analysis of demographic and clinical subgroups from Phase 3 randomized placebo-controlled trials",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13442215",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Predictors of Sexual Dysfunction in Unipolar Depression: A Register-Based Nested Case-Control Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442284",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy and Safety of Adjunctive Lumateperone 42 mg in Major Depressive Disorder: A Pooled Analysis of Demographic and Clinical Subgroups from 2 Phase 3 Randomized Placebo-Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556582",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "249. A head-to-head comparison of two biologically-based subtyping solutions for major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13443665",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Endogenous Lithium Status in Major Depression: A Retrospective Analysis of EDTA Blood Samples",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444688",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Predictive value of C-reactive Protein for antidepressant treatment response in patients with major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1347340",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.18.26365850",
          "title": "Association of neurotransmitter-based polygenic scores with antidepressant treatment outcomes in patients with major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-21",
          "journalTitle": null
        },
        {
          "id": "PMC13444050",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depression and glucidic metabolism: a prospective assessment of response to treatment with antidepressant drugs",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556391",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "217. SSVEP as a physiological biomarker of attentional bias and treatment response in adolescent Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13442657",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Association Between Childhood Neglect and Major Depressive Disorder: A Systematic Review, Meta-Analysis and Meta-Regression",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy of Probiotic Supplementation with Lactobacillus and Bifidobacterium in Major Depressive Disorder: A Meta-analysis of Randomized Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443727",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Lithium Prescription in Unipolar Depression: Findings from a Nationwide Greek Cohort Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13661943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PMC13443003",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effectiveness of Cognitive Remediation in Subjects with Major Depressive Disorder: 3-Month Follow-Up Results of a Multicenter Randomized Controlled Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1311246",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.0237.v1",
          "title": "Choosing Antidepressants When Depression Meets Insomnia: Comparative Efficacy, Sleep Effects, and Sexual-Function Trade-offs—A Narrative Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        },
        {
          "id": "PMC13442931",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effect Of Cariprazine On Metabolic Parameters In Patients Living With Major Depressive Disorder: A Systematic Review And Meta-Analysis",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441736",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Clinical Characteristics of Major Depressive Disorder in Children: Experience from the Child Psychiatry Department of Casablanca University",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442395",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Emotional Cognition in Major Depressive, Bipolar and Borderline Personality Disorder - a Comparative Study of Recognition of Emotion in Auditory and Visual Stimuli",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1308902",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.25.26361081",
          "title": "Adjunctive Psychobiotic  <i>Lactiplantibacillus plantarum</i>  PS128 Therapy and Escitalopram in Major Depressive Disorder: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PMC13442562",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The Neurobiology of Dual Diagnosis: Investigating the Shared Pathophysiology of Alcohol Use Disorder and Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442470",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "An algorithmic approach in cases of dual diagnosis - gaming disorder and major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1346357",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.18.26365862",
          "title": "Shared Social Brain Gray Matter Reductions in Depression, Schizophrenia, and Alcohol Use Disorder: A Meta-Analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-20",
          "journalTitle": null
        },
        {
          "id": "PMC13664290",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
          "pubYear": null,
          "pubType": "systematic-review; review",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13608885",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The expressions and m6A methylation modification patterns of mRNAs and lncRNAs in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Genet"
        },
        {
          "id": "PMC13601905",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Metabolomic dysregulation in the association between major depressive disorder and chronic pancreatitis: a large prospective cohort study",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Nutr"
        },
        {
          "id": "PMC13444869",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Breaking Barriers: Exploring New Treatment Approaches for Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441813",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major Depressive Disorder and Patterns of Antidepressant Prescription in Greece: Α Pharmacoepidemiological Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443006",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Return to work after major depressive disorder: predictive factors and reintegration strategies",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445404",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Transcranial Magnetic Stimulation Efficacy and Future Directions in Major Depressive Disorder: A Comprehensive Review",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442667",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Illness course variables as predictors of efficacy and speed of response to Spravaro in major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444383",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Reviewing Probiotics’ effects on Major depressive disorders in older adults: a systematic analysis of randomized controlled trails",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556670",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "749. Safety, tolerability, and efficacy data of 60 Hz white light stimulation in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13443874",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy and Safety of Triple Monoamine Reuptake Inhibitors for Major Depressive Disorder: Meta-analysis of Randomised Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556365",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "218. miR-221-3p mediates electroconvulsive therapy’s mechanisms in adolescent major depressive disorder: a translational study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556705",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "489. Task-based fMRI investigation of neural changes following acceptance and commitment therapy in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556701",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "355. PPARγ as a predictive biomarker for antidepressant response in major depressive disorder: insights from TNIP1 transcriptional regulation",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13443858",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "GLP-1 Agonist As Adjunct To Antidepressants In Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556506",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "250. Efficacy of adjunctive lumateperone 42 mg treatment across patient-reported depression symptoms in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556358",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "587. Female-specific role of interleukin 6 and C-reactive protein in individuals with major depressive disorder and comorbid obesity",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556626",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "365. Association between CYP2D6 genotype and treatment outcomes in hospitalized patients with major depressive disorder: a retrospective cohort study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556740",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "214. Magnetic seizure therapy for major depressive disorder: clinical efficacy, safety, and prefrontal activation measured by functional near-infrared spectroscopy",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556394",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "363. Angular gyrus as a key hub of treatment refractoriness and neuromodulation response in major depressive disorder: a data-driven structural covariance network analysis",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556477",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "290. Plasma neurofilament light chain levels in drug-free patients with major depressive disorder and changes after antidepressant treatment: a longitudinal pilot study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556810",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "439. Polygenic stratification reveals differential response to V1b antagonism in pre-exposed patients with major depressive disorder: a post-hoc analysis of the phase 2 OLIVE trial",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556549",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "252. Clinical application of psychedelic-assisted therapy in major depression and addictions",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13441862",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "What routine mental healthcare data could be used to predict response in major depression treatment?",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Association between blood concentration of sertraline and its effectiveness and safety in major depression: exploratory results of the PREDEP-SERT study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1314594",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10683316/v1",
          "title": "Electroconvulsive therapy modulates neurite density and free water in discrete white matter compartments in major depression",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-08",
          "journalTitle": null
        },
        {
          "id": "PPR1315605",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-9633682/v1",
          "title": "Case Report: Grade 2 oligodendroglioma presenting as treatment resistant major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-09",
          "journalTitle": null
        },
        {
          "id": "PPR1317739",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362568",
          "title": "Human genetic risk for major depressive disorder implicates motor cortex PVALB⁺ inhibitory neurons",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-10",
          "journalTitle": null
        },
        {
          "id": "PPR1336028",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.06.26364759",
          "title": "Neuroplasticity-Based Treatment Prioritization in Major Depressive Disorder: A Two-Cohort Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-07",
          "journalTitle": null
        },
        {
          "id": "PPR1321262",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10861845/v1",
          "title": "Baseline subgenual cingulate functional connectivity does not predict symptom-dimension-specific improvement during escitalopram treatment in major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-17",
          "journalTitle": null
        },
        {
          "id": "PPR1321121",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.1304.v1",
          "title": "Adjunctive Brexpiprazole in Major Depressive Disorder with Inadequate Response to Antidepressants: A Prospective Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-16",
          "journalTitle": null
        },
        {
          "id": "PPR1317770",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362462",
          "title": "Effects of sex, treatment resistance, and antidepressant treatment on monoamine oxidase B total distribution volume",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-10",
          "journalTitle": null
        },
        {
          "id": "PPR1317510",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/d7bc2_v1",
          "title": "Combined sleep deprivation and light therapy for depression in major depressive disorder and bipolar disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-11",
          "journalTitle": null
        },
        {
          "id": "PPR1340375",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-11194275/v1",
          "title": "Sex-dependent differences in matrix metalloproteinase-9 and inflammatory markers in postmortem brain of depressed subjects: Effect of pharmacological treatment and suicide",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-14",
          "journalTitle": null
        },
        {
          "id": "PPR1328258",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.18.752576",
          "title": "Major depressive disorder recurrence and medication status shape brain network topology",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-24",
          "journalTitle": null
        },
        {
          "id": "PPR1339733",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.0994.v1",
          "title": "Long-Term Fluoxetine Treatment Alters Fecal Microbiota and Induces Systemic Disruption in Sprague-Dawley Rats",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-12",
          "journalTitle": null
        },
        {
          "id": "PPR1339657",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.1070.v1",
          "title": "Does Depression Phenotype Predict Antidepressant Response? A Transdiagnostic Review of Phenotype-Specific Antidepressant Efficacy",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-12",
          "journalTitle": null
        },
        {
          "id": "PPR1323803",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10628442/v1",
          "title": "Multi-Feature 3D Deep Learning for Predicting Antidepressant Treatment Response from Structural MRI",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-21",
          "journalTitle": null
        },
        {
          "id": "PPR1318167",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362080",
          "title": "Chronic sensing during subcallosal cingulate deep brain stimulation captures ketamine-associated changes in major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-11",
          "journalTitle": null
        },
        {
          "id": "PPR1343552",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-11088167/v1",
          "title": "Striatal tissue iron in depressed and healthy individuals and the effect of buproprion",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": null
        },
        {
          "id": "PPR1324601",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10327913/v1",
          "title": "Treatment Resistant Depression: Perspective of Psychiatrists in Saudi Arabia",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-22",
          "journalTitle": null
        },
        {
          "id": "PPR1312706",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.01.26361949",
          "title": "Substance Use is Not Associated with Antidepressant Response to Transcranial Magnetic Stimulation",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        },
        {
          "id": "PPR1312767",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.31.26361809",
          "title": "Molecular Underpinnings of Retinal Traits Shared with Major Psychiatric Disorders",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        },
        {
          "id": "PPR1311324",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.0161.v1",
          "title": "Pharmacometabolomics of Psychotropic Drugs: Treatment Response, Adverse Effects, and Precision Psychiatry—A Narrative Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-02",
          "journalTitle": null
        },
        {
          "id": "PPR1307554",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10811698/v1",
          "title": "A Multilevel Mechanistic Platform for Antidepressant-Response Prediction Integrating Pharmacokinetics, Polypharmacology, Inflammation, Neuroplasticity, Large-Scale Networks and the Gut–Brain Axis: Chronological Development and Indicator-Level Evaluation Across 51 Drugs and 15 Drug–Nutraceutical Combinations",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-28",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "efficacy",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (\"publication bias\" OR placebo OR \"STAR*D\" OR \"clinical significance\" OR \"individual participant\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 91,
      "fetched": 91,
      "medline_count": 59,
      "pmids": [
        "42812643",
        "42778211",
        "42737920",
        "42680855",
        "42812942",
        "42742617",
        "42550483",
        "42815730",
        "42701110",
        "42774912",
        "42680780",
        "42802397",
        "42752587",
        "42815877",
        "42681589",
        "42690086",
        "42892401",
        "42684061",
        "42688558",
        "42702010",
        "42796411",
        "42680119",
        "42795740",
        "42766497",
        "42696738",
        "42707709",
        "42883713",
        "42745834",
        "42668924",
        "42670051",
        "42729393",
        "42756843",
        "42863798",
        "42756688",
        "42769949",
        "42879530",
        "42877783",
        "42805662",
        "42670435",
        "42749683",
        "42679601",
        "42701679",
        "42819418",
        "42663293",
        "42682977",
        "42721112",
        "42658027",
        "42830939",
        "42783499",
        "42358003",
        "42726702",
        "42733696",
        "42884023",
        "42756128",
        "42850904",
        "42729560",
        "42769822",
        "42616023",
        "42701687"
      ],
      "non_medline": [
        {
          "id": "PMC13442215",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Predictors of Sexual Dysfunction in Unipolar Depression: A Register-Based Nested Case-Control Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1339657",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.1070.v1",
          "title": "Does Depression Phenotype Predict Antidepressant Response? A Transdiagnostic Review of Phenotype-Specific Antidepressant Efficacy",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-12",
          "journalTitle": null
        },
        {
          "id": "PMC13443858",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "GLP-1 Agonist As Adjunct To Antidepressants In Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556506",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "250. Efficacy of adjunctive lumateperone 42 mg treatment across patient-reported depression symptoms in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556786",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "230. LSD microdosing for depression: hype or hope? A randomised controlled trial in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13443874",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy and Safety of Triple Monoamine Reuptake Inhibitors for Major Depressive Disorder: Meta-analysis of Randomised Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442284",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy and Safety of Adjunctive Lumateperone 42 mg in Major Depressive Disorder: A Pooled Analysis of Demographic and Clinical Subgroups from 2 Phase 3 Randomized Placebo-Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556380",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "193. Efficacy and safety of adjunctive lumateperone 42 mg in major depressive disorder: pooled analysis of demographic and clinical subgroups from Phase 3 randomized placebo-controlled trials",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556810",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "439. Polygenic stratification reveals differential response to V1b antagonism in pre-exposed patients with major depressive disorder: a post-hoc analysis of the phase 2 OLIVE trial",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13442032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy of Probiotic Supplementation with Lactobacillus and Bifidobacterium in Major Depressive Disorder: A Meta-analysis of Randomized Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442414",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Mind the gap: representation and outcomes of individuals with schizophrenia or major depressive disorder not eligible for randomized controlled trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444383",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Reviewing Probiotics’ effects on Major depressive disorders in older adults: a systematic analysis of randomized controlled trails",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441862",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "What routine mental healthcare data could be used to predict response in major depression treatment?",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1311246",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.0237.v1",
          "title": "Choosing Antidepressants When Depression Meets Insomnia: Comparative Efficacy, Sleep Effects, and Sexual-Function Trade-offs—A Narrative Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        },
        {
          "id": "PMC13441813",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major Depressive Disorder and Patterns of Antidepressant Prescription in Greece: Α Pharmacoepidemiological Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445065",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Bringing cost-effectiveness models to life: AI Replication of a published model of venlafaxine treatment in major depressive disorder using a large language model (LLM)",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442470",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "An algorithmic approach in cases of dual diagnosis - gaming disorder and major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PMC13661943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PPR1346357",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.18.26365862",
          "title": "Shared Social Brain Gray Matter Reductions in Depression, Schizophrenia, and Alcohol Use Disorder: A Meta-Analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-20",
          "journalTitle": null
        },
        {
          "id": "PPR1336028",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.06.26364759",
          "title": "Neuroplasticity-Based Treatment Prioritization in Major Depressive Disorder: A Two-Cohort Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-07",
          "journalTitle": null
        },
        {
          "id": "PMC13442395",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Emotional Cognition in Major Depressive, Bipolar and Borderline Personality Disorder - a Comparative Study of Recognition of Emotion in Auditory and Visual Stimuli",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1333678",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10879308/v1",
          "title": "Therapists’ Perspectives on the Psychotherapeutic Support in Psilocybin Treatment for Major Depressive Disorder: Insights from a Randomized Controlled Trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-05",
          "journalTitle": null
        },
        {
          "id": "PPR1308902",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.25.26361081",
          "title": "Adjunctive Psychobiotic  <i>Lactiplantibacillus plantarum</i>  PS128 Therapy and Escitalopram in Major Depressive Disorder: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PMC13664290",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
          "pubYear": null,
          "pubType": "systematic-review; review",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13674596",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": "bioRxiv"
        },
        {
          "id": "PMC13444050",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depression and glucidic metabolism: a prospective assessment of response to treatment with antidepressant drugs",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13680482",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Spatiotemporal feature-based investigation of major depressive disorder and emotion recognition using functional near infrared spectroscopy",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-21",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PPR1337148",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.06.26364737",
          "title": "Psychiatric comorbidity in dissociative identity disorder: A meta-analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-07",
          "journalTitle": null
        },
        {
          "id": "PPR1312842",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.29.748003",
          "title": "Postmortem Alterations of Metabotropic Glutamate Receptors across Neuropsychiatric Disorders: A Systematic Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        },
        {
          "id": "PPR1311324",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.0161.v1",
          "title": "Pharmacometabolomics of Psychotropic Drugs: Treatment Response, Adverse Effects, and Precision Psychiatry—A Narrative Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-02",
          "journalTitle": null
        },
        {
          "id": "PPR1307554",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10811698/v1",
          "title": "A Multilevel Mechanistic Platform for Antidepressant-Response Prediction Integrating Pharmacokinetics, Polypharmacology, Inflammation, Neuroplasticity, Large-Scale Networks and the Gut–Brain Axis: Chronological Development and Indicator-Level Evaluation Across 51 Drugs and 15 Drug–Nutraceutical Combinations",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-28",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "psychotherapy",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (psychotherap* OR \"cognitive behavioral\" OR \"behavioural activation\" OR exercise OR \"task sharing\" OR \"task-shared\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 145,
      "fetched": 145,
      "medline_count": 118,
      "pmids": [
        "42784817",
        "42795740",
        "42843278",
        "42779037",
        "42892100",
        "42766497",
        "42721164",
        "42879686",
        "42700486",
        "42663293",
        "42789363",
        "42710021",
        "42732834",
        "42413809",
        "42863798",
        "42726702",
        "42769822",
        "42714093",
        "42792385",
        "42550483",
        "42774912",
        "42812942",
        "42815884",
        "42807040",
        "42742617",
        "42736557",
        "42819210",
        "42796411",
        "42812173",
        "42732880",
        "42894373",
        "42892095",
        "40184540",
        "42819418",
        "42752567",
        "42789054",
        "42702010",
        "42737858",
        "42872469",
        "42883713",
        "42616023",
        "42815877",
        "42797527",
        "42766019",
        "42838229",
        "42679601",
        "42739877",
        "42680780",
        "42756843",
        "42721198",
        "42896406",
        "42879530",
        "42675332",
        "42729906",
        "42805955",
        "42760730",
        "42735276",
        "42709645",
        "42732835",
        "42865326",
        "42682977",
        "42794622",
        "42795930",
        "42696738",
        "42682166",
        "42877783",
        "42701679",
        "42863717",
        "42717325",
        "42765208",
        "42724084",
        "42769103",
        "42750260",
        "42873387",
        "42858129",
        "42793276",
        "42734915",
        "42680855",
        "42801310",
        "42754771",
        "42830939",
        "42756688",
        "42844936",
        "42783499",
        "42799462",
        "42889347",
        "42358003",
        "42869999",
        "42658027",
        "42749161",
        "42670051",
        "42669842",
        "42834832",
        "42732542",
        "42676104",
        "42669383",
        "42839301",
        "42664168",
        "42872182",
        "42748377",
        "42809770",
        "42890752",
        "42710691",
        "42678888",
        "42746369",
        "42668924",
        "42805662",
        "42777239",
        "42785391",
        "42799904",
        "42895746",
        "42684674",
        "42886483",
        "42729393",
        "42701687",
        "42796071",
        "42698078",
        "42686352"
      ],
      "non_medline": [
        {
          "id": "PMC13442470",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "An algorithmic approach in cases of dual diagnosis - gaming disorder and major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556705",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "489. Task-based fMRI investigation of neural changes following acceptance and commitment therapy in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13444869",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Breaking Barriers: Exploring New Treatment Approaches for Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PMC13445065",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Bringing cost-effectiveness models to life: AI Replication of a published model of venlafaxine treatment in major depressive disorder using a large language model (LLM)",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13661943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PPR1310193",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.29.26361710",
          "title": "The timeline of brain aging in major depression: A prospective study from before first-onset to established illness",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PMC13664290",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
          "pubYear": null,
          "pubType": "systematic-review; review",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13443006",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Return to work after major depressive disorder: predictive factors and reintegration strategies",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445404",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Transcranial Magnetic Stimulation Efficacy and Future Directions in Major Depressive Disorder: A Comprehensive Review",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442409",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Patient and Family Determinants of Caregiver Burden in Major Depressive Disorder: A Multicenter Observational Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444738",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depressive disorders related to Post-traumatic cases in Geriatic Patients with traumatic brain Injuries",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441736",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Clinical Characteristics of Major Depressive Disorder in Children: Experience from the Child Psychiatry Department of Casablanca University",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444423",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depressive disorders related to Post-traumatic cases after cervical spine injuries in amateur athletes",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443003",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effectiveness of Cognitive Remediation in Subjects with Major Depressive Disorder: 3-Month Follow-Up Results of a Multicenter Randomized Controlled Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444618",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Impact of Remote Patient Monitoring On Major Depressive episode And Bipolar Disorder Treatment Outcomes: EC-102 Randomized Controlled Trial",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443547",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The efficacy of transcranial direct current stimulation (tDCS) combined with cognitive behavioural therapy for major depressive disorder: a systematic review and meta-analysis of randomised controlled trials.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443665",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Endogenous Lithium Status in Major Depression: A Retrospective Analysis of EDTA Blood Samples",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442185",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Electroconvulsive Therapy in a Patient with Somatic Symptom Disorder and Major Depression: A Case Report",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556549",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "252. Clinical application of psychedelic-assisted therapy in major depression and addictions",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13441658",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Digital psychiatry in major depression and suicidality: emotion tracking, smart monitoring, and AI-supported care",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441862",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "What routine mental healthcare data could be used to predict response in major depression treatment?",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Distinguishing Major Depression from Bipolar Disorders: DSM-5 Dimensional Model and Depression-related Psychotic Features",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1317739",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362568",
          "title": "Human genetic risk for major depressive disorder implicates motor cortex PVALB⁺ inhibitory neurons",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-10",
          "journalTitle": null
        },
        {
          "id": "PPR1333678",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10879308/v1",
          "title": "Therapists’ Perspectives on the Psychotherapeutic Support in Psilocybin Treatment for Major Depressive Disorder: Insights from a Randomized Controlled Trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-05",
          "journalTitle": null
        },
        {
          "id": "PPR1329762",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.2452.v1",
          "title": "Voided REM Sleep (V-REM): A Candidate Biomarker Linking Treatment-Resistant PTSD and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PPR1317728",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362466",
          "title": "Lifestyle therapy versus cognitive behavioural therapy for adults with mood disorders: a randomised non-inferiority trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-10",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "resistance",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (\"treatment resistant\" OR \"treatment-resistant\" OR augmentation OR lithium OR sequencing) AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 154,
      "fetched": 154,
      "medline_count": 115,
      "pmids": [
        "42863798",
        "42812942",
        "42678910",
        "42783499",
        "42814927",
        "42682977",
        "42742617",
        "42815730",
        "42688594",
        "42849015",
        "42756843",
        "42682166",
        "42803524",
        "42896406",
        "42748866",
        "42870751",
        "42865326",
        "42700487",
        "42878501",
        "42829941",
        "42765892",
        "42766019",
        "42797527",
        "42794499",
        "42878230",
        "42684694",
        "42702010",
        "42762641",
        "42788073",
        "42658027",
        "42767040",
        "42721112",
        "42745218",
        "30855854",
        "42668390",
        "42732542",
        "42729848",
        "42883713",
        "42751846",
        "42766497",
        "42864698",
        "42783367",
        "42830939",
        "42727730",
        "42858129",
        "42686996",
        "42766673",
        "42812643",
        "42684061",
        "42869167",
        "42761770",
        "42830219",
        "42789054",
        "42749683",
        "42737920",
        "42742966",
        "42756688",
        "42789363",
        "42799904",
        "42843471",
        "42765861",
        "42769822",
        "42696738",
        "42732835",
        "42379141",
        "42769949",
        "42892401",
        "42739877",
        "42813034",
        "42864498",
        "42755741",
        "42707775",
        "42769103",
        "42699697",
        "42688891",
        "42812173",
        "42819418",
        "42663293",
        "42756176",
        "42737858",
        "42736349",
        "42707709",
        "42840696",
        "42841964",
        "42687377",
        "42779163",
        "42884023",
        "42745834",
        "42670051",
        "42630054",
        "42729906",
        "42735274",
        "42774912",
        "42698280",
        "42829528",
        "42711407",
        "42768327",
        "42613180",
        "42771084",
        "42887658",
        "42784817",
        "42778763",
        "42679763",
        "42728740",
        "42668924",
        "42753254",
        "42794424",
        "42616023",
        "42729393",
        "42723246",
        "42807520",
        "42316910",
        "42723086",
        "42729560",
        "42777239"
      ],
      "non_medline": [
        {
          "id": "PMC13443727",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Lithium Prescription in Unipolar Depression: Findings from a Nationwide Greek Cohort Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556365",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "218. miR-221-3p mediates electroconvulsive therapy’s mechanisms in adolescent major depressive disorder: a translational study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1324601",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10327913/v1",
          "title": "Treatment Resistant Depression: Perspective of Psychiatrists in Saudi Arabia",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-22",
          "journalTitle": null
        },
        {
          "id": "PMC13442395",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Emotional Cognition in Major Depressive, Bipolar and Borderline Personality Disorder - a Comparative Study of Recognition of Emotion in Auditory and Visual Stimuli",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443858",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "GLP-1 Agonist As Adjunct To Antidepressants In Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442657",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Association Between Childhood Neglect and Major Depressive Disorder: A Systematic Review, Meta-Analysis and Meta-Regression",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1315605",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-9633682/v1",
          "title": "Case Report: Grade 2 oligodendroglioma presenting as treatment resistant major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-09",
          "journalTitle": null
        },
        {
          "id": "PMC13444050",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depression and glucidic metabolism: a prospective assessment of response to treatment with antidepressant drugs",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1329762",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.2452.v1",
          "title": "Voided REM Sleep (V-REM): A Candidate Biomarker Linking Treatment-Resistant PTSD and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PMC13556394",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "363. Angular gyrus as a key hub of treatment refractoriness and neuromodulation response in major depressive disorder: a data-driven structural covariance network analysis",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556549",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "252. Clinical application of psychedelic-assisted therapy in major depression and addictions",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556810",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "439. Polygenic stratification reveals differential response to V1b antagonism in pre-exposed patients with major depressive disorder: a post-hoc analysis of the phase 2 OLIVE trial",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13444613",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Clinical Validation of Patient-Reported Cognitive Assessment Tools for Adverse Effects of Electroconvulsive Therapy in Patients with Unipolar Depression",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445404",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Transcranial Magnetic Stimulation Efficacy and Future Directions in Major Depressive Disorder: A Comprehensive Review",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442409",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Patient and Family Determinants of Caregiver Burden in Major Depressive Disorder: A Multicenter Observational Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443547",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The efficacy of transcranial direct current stimulation (tDCS) combined with cognitive behavioural therapy for major depressive disorder: a systematic review and meta-analysis of randomised controlled trials.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444959",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Predicting rTMS Treatment Response in Major Depression Using Minimal-Electrode EEG and Machine Learning",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442931",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effect Of Cariprazine On Metabolic Parameters In Patients Living With Major Depressive Disorder: A Systematic Review And Meta-Analysis",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442185",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Electroconvulsive Therapy in a Patient with Somatic Symptom Disorder and Major Depression: A Case Report",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443665",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Endogenous Lithium Status in Major Depression: A Retrospective Analysis of EDTA Blood Samples",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1314594",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10683316/v1",
          "title": "Electroconvulsive therapy modulates neurite density and free water in discrete white matter compartments in major depression",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-08",
          "journalTitle": null
        },
        {
          "id": "PPR1332876",
          "source": "PPR",
          "pmid": null,
          "doi": "10.14293/pr2199.004576.v1",
          "title": "Voided REM Sleep (V-REM)",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-28",
          "journalTitle": null
        },
        {
          "id": "PPR1339657",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.1070.v1",
          "title": "Does Depression Phenotype Predict Antidepressant Response? A Transdiagnostic Review of Phenotype-Specific Antidepressant Efficacy",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-12",
          "journalTitle": null
        },
        {
          "id": "PMC13674596",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": "bioRxiv"
        },
        {
          "id": "PMC13445032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Association between blood concentration of sertraline and its effectiveness and safety in major depression: exploratory results of the PREDEP-SERT study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443003",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effectiveness of Cognitive Remediation in Subjects with Major Depressive Disorder: 3-Month Follow-Up Results of a Multicenter Randomized Controlled Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1317770",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362462",
          "title": "Effects of sex, treatment resistance, and antidepressant treatment on monoamine oxidase B total distribution volume",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-10",
          "journalTitle": null
        },
        {
          "id": "PPR1308951",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.25.26361076",
          "title": "Multiday rhythms shape mood dynamics in depression",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PMC13664290",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
          "pubYear": null,
          "pubType": "systematic-review; review",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PPR1318167",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362080",
          "title": "Chronic sensing during subcallosal cingulate deep brain stimulation captures ketamine-associated changes in major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-11",
          "journalTitle": null
        },
        {
          "id": "PMC13556682",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "487. Genome-wide DNA methylation analysis reveals epigenetic signatures of early life stress in major depressive disorder patients",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13441991",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Genome-Wide DNA Methylation Analysis Reveals Epigenetic Signatures of Early Life Stress in Major Depressive Disorder Patients",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1332977",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.27.754773",
          "title": "Alignment with sex-typical brain architecture: Links to mood pathology, sex hormones and transcriptomics of neurodegenerative conditions",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-02",
          "journalTitle": null
        },
        {
          "id": "PMC13441644",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Bidirectional Associations Between Highly Processed Food Consumption and Major Depressive Disorder: A Cross-Sectional Study on Adults Residing in Madrid and Barcelona (Edad con Salud)",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1330110",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-9707995/v1",
          "title": "Balancing Utility and Privacy: Evaluating Synthetic Gene Expression Data with a Novel Dilution Metric for Feature Stability",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PPR1308902",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.25.26361081",
          "title": "Adjunctive Psychobiotic  <i>Lactiplantibacillus plantarum</i>  PS128 Therapy and Escitalopram in Major Depressive Disorder: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PPR1330586",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.28.26364187",
          "title": "Cortical hemodynamic dysregulation is linked to peripheral NIMETOX pathways in major depressive disorder: an 89-channel fNIRS systems-biology study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PPR1328587",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.25.26363706",
          "title": "A founder population reveals genetic variation with major effect on serious mental illness",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-27",
          "journalTitle": null
        },
        {
          "id": "PPR1312767",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.31.26361809",
          "title": "Molecular Underpinnings of Retinal Traits Shared with Major Psychiatric Disorders",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "glutamatergic",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (ketamine OR esketamine OR dextromethorphan OR hydroxynorketamine OR zelquistinel) AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 58,
      "fetched": 58,
      "medline_count": 41,
      "pmids": [
        "42616023",
        "42894300",
        "42894301",
        "42762641",
        "42877783",
        "42756688",
        "42735276",
        "42658027",
        "42702010",
        "42838387",
        "42682977",
        "42812942",
        "42692098",
        "42783499",
        "42767040",
        "42670051",
        "42803524",
        "42896406",
        "42879530",
        "42865326",
        "42755741",
        "42748866",
        "42684694",
        "42869167",
        "42745834",
        "42863798",
        "42721112",
        "42756843",
        "42767564",
        "42858129",
        "42721198",
        "42766497",
        "42883713",
        "42819418",
        "42668924",
        "42663293",
        "42729906",
        "42729848",
        "42842414",
        "42830939",
        "42613180"
      ],
      "non_medline": [
        {
          "id": "PMC13443858",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "GLP-1 Agonist As Adjunct To Antidepressants In Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442657",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Association Between Childhood Neglect and Major Depressive Disorder: A Systematic Review, Meta-Analysis and Meta-Regression",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1311324",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.0161.v1",
          "title": "Pharmacometabolomics of Psychotropic Drugs: Treatment Response, Adverse Effects, and Precision Psychiatry—A Narrative Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-02",
          "journalTitle": null
        },
        {
          "id": "PMC13443003",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effectiveness of Cognitive Remediation in Subjects with Major Depressive Disorder: 3-Month Follow-Up Results of a Multicenter Randomized Controlled Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442409",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Patient and Family Determinants of Caregiver Burden in Major Depressive Disorder: A Multicenter Observational Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13661943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13442395",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Emotional Cognition in Major Depressive, Bipolar and Borderline Personality Disorder - a Comparative Study of Recognition of Emotion in Auditory and Visual Stimuli",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy of Probiotic Supplementation with Lactobacillus and Bifidobacterium in Major Depressive Disorder: A Meta-analysis of Randomized Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443547",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The efficacy of transcranial direct current stimulation (tDCS) combined with cognitive behavioural therapy for major depressive disorder: a systematic review and meta-analysis of randomised controlled trials.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556549",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "252. Clinical application of psychedelic-assisted therapy in major depression and addictions",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13444050",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depression and glucidic metabolism: a prospective assessment of response to treatment with antidepressant drugs",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442284",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy and Safety of Adjunctive Lumateperone 42 mg in Major Depressive Disorder: A Pooled Analysis of Demographic and Clinical Subgroups from 2 Phase 3 Randomized Placebo-Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445104",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Exploring the association between cognitive performances, early life traumas, and lifetime suicide attempts in Major Depressive Disorder: an analysis of the PROMPT study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444383",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Reviewing Probiotics’ effects on Major depressive disorders in older adults: a systematic analysis of randomized controlled trails",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1310996",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.28.26361493",
          "title": "<i>In Vitro</i>  Ketamine Attenuates Immune Sensitization in Major Depressive Disorder in a Concentration-Dependent Manner",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-02",
          "journalTitle": null
        },
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PPR1318167",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362080",
          "title": "Chronic sensing during subcallosal cingulate deep brain stimulation captures ketamine-associated changes in major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-11",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "neuromodulation",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (electroconvulsive OR \"transcranial magnetic\" OR iTBS OR tDCS OR \"vagus nerve\" OR \"deep brain stimulation\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 108,
      "fetched": 108,
      "medline_count": 86,
      "pmids": [
        "42699697",
        "42769822",
        "42735276",
        "42727730",
        "42878230",
        "42688594",
        "42789054",
        "42769949",
        "42799904",
        "42658027",
        "42675468",
        "42766673",
        "42858129",
        "42670051",
        "42895746",
        "42830939",
        "42794499",
        "42783499",
        "42682977",
        "42855128",
        "42878501",
        "42839296",
        "42801310",
        "42668924",
        "40184540",
        "42838181",
        "42880443",
        "42700487",
        "42721164",
        "42721517",
        "42877696",
        "42766019",
        "42700486",
        "42789363",
        "42863253",
        "42892100",
        "42844676",
        "42737858",
        "42707709",
        "42674239",
        "42745218",
        "42696738",
        "42785385",
        "42829029",
        "41862185",
        "42783367",
        "42812942",
        "42753347",
        "42721198",
        "42864698",
        "40132108",
        "42879997",
        "42860592",
        "42843471",
        "30855854",
        "40168143",
        "42810830",
        "42707775",
        "42863719",
        "42785233",
        "42687377",
        "42721112",
        "42829057",
        "42883713",
        "42731592",
        "42698872",
        "42723086",
        "42841964",
        "42686996",
        "42729560",
        "42688891",
        "42745834",
        "42680780",
        "42807040",
        "42701679",
        "42768327",
        "42729906",
        "42756688",
        "42819418",
        "42879530",
        "42807528",
        "42679601",
        "42761770",
        "42830015",
        "42663293",
        "42616023"
      ],
      "non_medline": [
        {
          "id": "PMC13444613",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Clinical Validation of Patient-Reported Cognitive Assessment Tools for Adverse Effects of Electroconvulsive Therapy in Patients with Unipolar Depression",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442395",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Emotional Cognition in Major Depressive, Bipolar and Borderline Personality Disorder - a Comparative Study of Recognition of Emotion in Auditory and Visual Stimuli",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442185",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Electroconvulsive Therapy in a Patient with Somatic Symptom Disorder and Major Depression: A Case Report",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445404",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Transcranial Magnetic Stimulation Efficacy and Future Directions in Major Depressive Disorder: A Comprehensive Review",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556394",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "363. Angular gyrus as a key hub of treatment refractoriness and neuromodulation response in major depressive disorder: a data-driven structural covariance network analysis",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13664290",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
          "pubYear": null,
          "pubType": "systematic-review; review",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13443547",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The efficacy of transcranial direct current stimulation (tDCS) combined with cognitive behavioural therapy for major depressive disorder: a systematic review and meta-analysis of randomised controlled trials.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442409",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Patient and Family Determinants of Caregiver Burden in Major Depressive Disorder: A Multicenter Observational Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556365",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "218. miR-221-3p mediates electroconvulsive therapy’s mechanisms in adolescent major depressive disorder: a translational study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1336017",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.05.26364655",
          "title": "Accelerated high-capacity 6 mA transcranial direct current stimulation for major depression",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-07",
          "journalTitle": null
        },
        {
          "id": "PMC13556582",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "249. A head-to-head comparison of two biologically-based subtyping solutions for major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13444959",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Predicting rTMS Treatment Response in Major Depression Using Minimal-Electrode EEG and Machine Learning",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1311047",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.27.746330",
          "title": "Spacing theta-burst stimulation enhances synaptic potentiation in the vulnerable prefrontal cortex",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": null
        },
        {
          "id": "PMC13444383",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Reviewing Probiotics’ effects on Major depressive disorders in older adults: a systematic analysis of randomized controlled trails",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556740",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "214. Magnetic seizure therapy for major depressive disorder: clinical efficacy, safety, and prefrontal activation measured by functional near-infrared spectroscopy",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1314594",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10683316/v1",
          "title": "Electroconvulsive therapy modulates neurite density and free water in discrete white matter compartments in major depression",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-08",
          "journalTitle": null
        },
        {
          "id": "PPR1318167",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362080",
          "title": "Chronic sensing during subcallosal cingulate deep brain stimulation captures ketamine-associated changes in major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-11",
          "journalTitle": null
        },
        {
          "id": "PPR1312706",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.01.26361949",
          "title": "Substance Use is Not Associated with Antidepressant Response to Transcranial Magnetic Stimulation",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        },
        {
          "id": "PMC13661943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PPR1342624",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.11.26365174",
          "title": "Discrete cortico-hippocampal circuit states underlie mood state transitions in depression",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-13",
          "journalTitle": null
        },
        {
          "id": "PMC13674596",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": "bioRxiv"
        }
      ]
    },
    {
      "topic": "novel",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (psilocybin OR psychedelic* OR neurosteroid* OR zuranolone OR brexanolone OR CYB003 OR \"GM-2505\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 22,
      "fetched": 22,
      "medline_count": 15,
      "pmids": [
        "42663293",
        "42750260",
        "42658027",
        "42732542",
        "42834832",
        "42379141",
        "42794499",
        "42735276",
        "42616023",
        "42869167",
        "42896406",
        "42879530",
        "42865326",
        "42794622",
        "42809944"
      ],
      "non_medline": [
        {
          "id": "PPR1333678",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10879308/v1",
          "title": "Therapists’ Perspectives on the Psychotherapeutic Support in Psilocybin Treatment for Major Depressive Disorder: Insights from a Randomized Controlled Trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-05",
          "journalTitle": null
        },
        {
          "id": "PMC13556549",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "252. Clinical application of psychedelic-assisted therapy in major depression and addictions",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1315197",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.03.26362170",
          "title": "Who Is Reached by Supervised Psilocybin Services? Oregon Services Versus National Psilocybin Use",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-07",
          "journalTitle": null
        },
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PMC13556786",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "230. LSD microdosing for depression: hype or hope? A randomised controlled trial in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13441862",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "What routine mental healthcare data could be used to predict response in major depression treatment?",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1312706",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.01.26361949",
          "title": "Substance Use is Not Associated with Antidepressant Response to Transcranial Magnetic Stimulation",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "prediction",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (biomarker* OR pharmacogen* OR prediction OR \"machine learning\" OR \"digital phenotyping\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 245,
      "fetched": 245,
      "medline_count": 186,
      "pmids": [
        "42725756",
        "42766673",
        "42756843",
        "42785392",
        "42726636",
        "42710412",
        "42765605",
        "42732835",
        "42833865",
        "42767042",
        "42826878",
        "42721164",
        "42887784",
        "42707775",
        "42742617",
        "42706232",
        "42834754",
        "42754579",
        "42769822",
        "42801835",
        "42624134",
        "42716347",
        "42722301",
        "42826767",
        "42840883",
        "42785393",
        "42794499",
        "42785390",
        "42775302",
        "42895100",
        "42826821",
        "42702788",
        "42869999",
        "42812942",
        "42765861",
        "42846268",
        "42877696",
        "42805955",
        "42883713",
        "42702010",
        "42833406",
        "42806848",
        "41880255",
        "42843469",
        "42884023",
        "42887530",
        "42684674",
        "42753254",
        "42875717",
        "42819210",
        "42851958",
        "42780703",
        "42732880",
        "42894373",
        "42829057",
        "42792438",
        "42699697",
        "42729848",
        "42774912",
        "42734915",
        "42855128",
        "42783499",
        "42794622",
        "42871390",
        "42735276",
        "42797527",
        "42721198",
        "42689366",
        "42874811",
        "42745834",
        "42737858",
        "42787408",
        "42696128",
        "42839301",
        "42830939",
        "42719402",
        "42698280",
        "42681589",
        "42729906",
        "42815877",
        "42861501",
        "42756176",
        "42700487",
        "42755741",
        "42723086",
        "42896406",
        "42779163",
        "42863253",
        "42685988",
        "42736557",
        "42707709",
        "42879530",
        "42803524",
        "42630054",
        "42705363",
        "42700763",
        "42810627",
        "42726702",
        "42796411",
        "42771084",
        "42861312",
        "42686088",
        "42819418",
        "42749683",
        "42892100",
        "42822187",
        "42777239",
        "42812643",
        "42413809",
        "42813034",
        "42752169",
        "42769103",
        "42870751",
        "42807528",
        "42866549",
        "42710693",
        "42843279",
        "42763552",
        "42815731",
        "42765208",
        "42751051",
        "42811409",
        "42744142",
        "42680780",
        "42829528",
        "42824397",
        "42679601",
        "30725910",
        "42688822",
        "42871667",
        "42788145",
        "42807520",
        "42760730",
        "42663293",
        "42696738",
        "42858129",
        "42753347",
        "42806433",
        "42883782",
        "42739724",
        "42768327",
        "42771937",
        "42778763",
        "42795740",
        "42670051",
        "42668072",
        "42812173",
        "42793276",
        "42769575",
        "42777933",
        "42838181",
        "42826818",
        "42682166",
        "42822715",
        "42721112",
        "42810830",
        "42840696",
        "42860592",
        "42698177",
        "42770453",
        "42841964",
        "42729560",
        "42731592",
        "42710732",
        "42797287",
        "42728740",
        "42733696",
        "42669383",
        "42748377",
        "42764573",
        "42709166",
        "42890752",
        "42872182",
        "42858801",
        "42710691",
        "42616023",
        "42749778",
        "42710021",
        "42724084",
        "42794424",
        "42676104",
        "42889194",
        "42783367",
        "42901213",
        "42716055",
        "42756839"
      ],
      "non_medline": [
        {
          "id": "PMC13643535",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Machine learning classification of fNIRS signals in patients with major depressive disorder and healthy controls",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-08",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13444959",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Predicting rTMS Treatment Response in Major Depression Using Minimal-Electrode EEG and Machine Learning",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442414",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Mind the gap: representation and outcomes of individuals with schizophrenia or major depressive disorder not eligible for randomized controlled trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444688",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Predictive value of C-reactive Protein for antidepressant treatment response in patients with major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556678",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "602. Neurobiological subtyping of major depression identifies distinct cardiometabolic risk profiles in UK Biobank",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13680482",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Spatiotemporal feature-based investigation of major depressive disorder and emotion recognition using functional near infrared spectroscopy",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-21",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PPR1310193",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.29.26361710",
          "title": "The timeline of brain aging in major depression: A prospective study from before first-onset to established illness",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PMC13664290",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
          "pubYear": null,
          "pubType": "systematic-review; review",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13556786",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "230. LSD microdosing for depression: hype or hope? A randomised controlled trial in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13443727",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Lithium Prescription in Unipolar Depression: Findings from a Nationwide Greek Cohort Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1323803",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10628442/v1",
          "title": "Multi-Feature 3D Deep Learning for Predicting Antidepressant Treatment Response from Structural MRI",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-21",
          "journalTitle": null
        },
        {
          "id": "PMC13442246",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Prediction of the onset of mood disorders in the offspring of parents with bipolar and major depressive disorders",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PPR1319124",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.750125",
          "title": "Multi-Methodological Characterization of Sleep Deprivation: From Standard EEG Power Spectra to Aperiodic Dynamics in Humans and Mice",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-14",
          "journalTitle": null
        },
        {
          "id": "PMC13443006",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Return to work after major depressive disorder: predictive factors and reintegration strategies",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556590",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "242. The effect of childhood trauma on drug resistance in major depressive disorder - results from the international PROMPT study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13445404",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Transcranial Magnetic Stimulation Efficacy and Future Directions in Major Depressive Disorder: A Comprehensive Review",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441862",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "What routine mental healthcare data could be used to predict response in major depression treatment?",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13674596",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": "bioRxiv"
        },
        {
          "id": "PMC13608885",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The expressions and m6A methylation modification patterns of mRNAs and lncRNAs in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Genet"
        },
        {
          "id": "PPR1339657",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.1070.v1",
          "title": "Does Depression Phenotype Predict Antidepressant Response? A Transdiagnostic Review of Phenotype-Specific Antidepressant Efficacy",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-12",
          "journalTitle": null
        },
        {
          "id": "PMC13601905",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Metabolomic dysregulation in the association between major depressive disorder and chronic pancreatitis: a large prospective cohort study",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Nutr"
        },
        {
          "id": "PMC13646898",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Correction to ‘Predictive value of biomarker signatures for suicide risk in hospitalised patients with major depressive disorders: A multicentre study in Shanghai’",
          "pubYear": "2026",
          "pubType": "correction; corrected and republished article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-01",
          "journalTitle": "Gen Psychiatr"
        },
        {
          "id": "PMC13661943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13445104",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Exploring the association between cognitive performances, early life traumas, and lifetime suicide attempts in Major Depressive Disorder: an analysis of the PROMPT study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441813",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major Depressive Disorder and Patterns of Antidepressant Prescription in Greece: Α Pharmacoepidemiological Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Association between blood concentration of sertraline and its effectiveness and safety in major depression: exploratory results of the PREDEP-SERT study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556582",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "249. A head-to-head comparison of two biologically-based subtyping solutions for major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556391",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "217. SSVEP as a physiological biomarker of attentional bias and treatment response in adolescent Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13444383",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Reviewing Probiotics’ effects on Major depressive disorders in older adults: a systematic analysis of randomized controlled trails",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556701",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "355. PPARγ as a predictive biomarker for antidepressant response in major depressive disorder: insights from TNIP1 transcriptional regulation",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13442395",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Emotional Cognition in Major Depressive, Bipolar and Borderline Personality Disorder - a Comparative Study of Recognition of Emotion in Auditory and Visual Stimuli",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443858",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "GLP-1 Agonist As Adjunct To Antidepressants In Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556358",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "587. Female-specific role of interleukin 6 and C-reactive protein in individuals with major depressive disorder and comorbid obesity",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556626",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "365. Association between CYP2D6 genotype and treatment outcomes in hospitalized patients with major depressive disorder: a retrospective cohort study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556740",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "214. Magnetic seizure therapy for major depressive disorder: clinical efficacy, safety, and prefrontal activation measured by functional near-infrared spectroscopy",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556477",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "290. Plasma neurofilament light chain levels in drug-free patients with major depressive disorder and changes after antidepressant treatment: a longitudinal pilot study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13556810",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "439. Polygenic stratification reveals differential response to V1b antagonism in pre-exposed patients with major depressive disorder: a post-hoc analysis of the phase 2 OLIVE trial",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1313962",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.02.26362049",
          "title": "Genetic and epigenetic architecture of mass spectrometry-derived lipids in blood and their role in lifetime Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-06",
          "journalTitle": null
        },
        {
          "id": "PPR1318221",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.09.26362608",
          "title": "A Systems Biology Model Linking Peripheral NIMETOX Biomarkers to Multilevel Brain Structural and Functional Alterations Across Major Depression and Schizophrenia",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-11",
          "journalTitle": null
        },
        {
          "id": "PPR1342587",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.11.26365268",
          "title": "Reduced Systemic Homeostatic and Endothelial Protective Capacity in Adolescent Major Depression: Associations with Early-Life Adversity and Clinical Phenotypes",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-13",
          "journalTitle": null
        },
        {
          "id": "PPR1321262",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10861845/v1",
          "title": "Baseline subgenual cingulate functional connectivity does not predict symptom-dimension-specific improvement during escitalopram treatment in major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-17",
          "journalTitle": null
        },
        {
          "id": "PPR1307554",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10811698/v1",
          "title": "A Multilevel Mechanistic Platform for Antidepressant-Response Prediction Integrating Pharmacokinetics, Polypharmacology, Inflammation, Neuroplasticity, Large-Scale Networks and the Gut–Brain Axis: Chronological Development and Indicator-Level Evaluation Across 51 Drugs and 15 Drug–Nutraceutical Combinations",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-28",
          "journalTitle": null
        },
        {
          "id": "PPR1335002",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10948059/v1",
          "title": "Cross-tissue integrative transcriptomics identifies peripheral blood biomarkers associated with the neuroimmune molecular landscape in major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-06",
          "journalTitle": null
        },
        {
          "id": "PPR1329762",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.2452.v1",
          "title": "Voided REM Sleep (V-REM): A Candidate Biomarker Linking Treatment-Resistant PTSD and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PPR1347340",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.18.26365850",
          "title": "Association of neurotransmitter-based polygenic scores with antidepressant treatment outcomes in patients with major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-21",
          "journalTitle": null
        },
        {
          "id": "PPR1340721",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-8177826/v1",
          "title": "Cellular senescence changes and their association with brain structure in schizophrenia and major depressive disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-14",
          "journalTitle": null
        },
        {
          "id": "PPR1336028",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.06.26364759",
          "title": "Neuroplasticity-Based Treatment Prioritization in Major Depressive Disorder: A Two-Cohort Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-07",
          "journalTitle": null
        },
        {
          "id": "PPR1346384",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.18.26365736",
          "title": "Dysfunctional Sleep Beliefs and Attitudes in Major Depressive Disorder: Dimensional Associations with Clinical Phenotypes and Gut-Neuroimmune-Metabolic-Oxidative Pathways",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-20",
          "journalTitle": null
        },
        {
          "id": "PPR1309049",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.27.26361547",
          "title": "Epigenetic and Immunometabolic Signatures of Suicidal Behavior in Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PPR1331786",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.28.26364141",
          "title": "Transdiagnostic metabolic architecture across major depressive disorder and schizophrenia: a NIMETOX systems-biology approach",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PPR1330586",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.28.26364187",
          "title": "Cortical hemodynamic dysregulation is linked to peripheral NIMETOX pathways in major depressive disorder: an 89-channel fNIRS systems-biology study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PPR1311324",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.0161.v1",
          "title": "Pharmacometabolomics of Psychotropic Drugs: Treatment Response, Adverse Effects, and Precision Psychiatry—A Narrative Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-02",
          "journalTitle": null
        },
        {
          "id": "PPR1332876",
          "source": "PPR",
          "pmid": null,
          "doi": "10.14293/pr2199.004576.v1",
          "title": "Voided REM Sleep (V-REM)",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-28",
          "journalTitle": null
        },
        {
          "id": "PPR1312767",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.31.26361809",
          "title": "Molecular Underpinnings of Retinal Traits Shared with Major Psychiatric Disorders",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-03",
          "journalTitle": null
        },
        {
          "id": "PPR1344289",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.15.26365624",
          "title": "A clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of psychiatric disorders",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": null
        },
        {
          "id": "PPR1331512",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/6f48v_v2",
          "title": "Digital Twins in Mental Health Care: A Qualitative Study on Subjective Relevance, Acceptability and Implementation Considerations Co-Designed, Co-Produced and Co-Written with Experts by Experience and Academics",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-30",
          "journalTitle": null
        },
        {
          "id": "PPR1330110",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-9707995/v1",
          "title": "Balancing Utility and Privacy: Evaluating Synthetic Gene Expression Data with a Novel Dilution Metric for Feature Stability",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PPR1320038",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.13.26362400",
          "title": "Cumulative Indicators of Circadian Rhythm Disturbance and its Clinical, Functional and Genetic Correlates in the Brisbane Longitudinal Twin Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-14",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "mortality-safety",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (suicid* OR mortality OR safety OR \"adverse effect\" OR mania OR overdose) AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 268,
      "fetched": 268,
      "medline_count": 196,
      "pmids": [
        "42688594",
        "42725756",
        "42774912",
        "42684694",
        "42872469",
        "42758600",
        "42737920",
        "42792450",
        "42721164",
        "42766019",
        "30725910",
        "42756688",
        "28613681",
        "42696738",
        "31747213",
        "42812942",
        "30855854",
        "42721198",
        "42749683",
        "42830939",
        "42767042",
        "42797527",
        "32644424",
        "42682977",
        "42678910",
        "42783499",
        "42684674",
        "42689366",
        "42668390",
        "42757108",
        "42735274",
        "42794424",
        "42550483",
        "42710412",
        "42880279",
        "42766497",
        "42670435",
        "42658027",
        "42894300",
        "42687377",
        "42701679",
        "42795740",
        "42698177",
        "41247288",
        "42819210",
        "42739877",
        "42817096",
        "42851958",
        "42841689",
        "42785385",
        "42844676",
        "42663293",
        "42720675",
        "42802397",
        "42894373",
        "42751846",
        "42679601",
        "42737858",
        "42584886",
        "42812643",
        "42698280",
        "42745218",
        "42875717",
        "42794499",
        "42815877",
        "42753853",
        "42785386",
        "42707775",
        "42769949",
        "42701110",
        "42752567",
        "42707709",
        "40132108",
        "42877783",
        "42792438",
        "42870751",
        "42789363",
        "42760730",
        "42799462",
        "42779162",
        "42729906",
        "42681589",
        "42822715",
        "42880603",
        "42736557",
        "42688558",
        "42819418",
        "42745799",
        "42752169",
        "42750260",
        "42779163",
        "42729184",
        "42685988",
        "42769103",
        "42722619",
        "42788073",
        "42756843",
        "42829833",
        "42698078",
        "42731320",
        "42801835",
        "42756176",
        "42793276",
        "42778211",
        "42895746",
        "42861207",
        "42764140",
        "42838387",
        "42616023",
        "42710718",
        "42755741",
        "42784817",
        "42732835",
        "42767564",
        "42807528",
        "42710716",
        "42668924",
        "42630054",
        "42765208",
        "42849853",
        "42751051",
        "42794622",
        "42840696",
        "42771084",
        "42729393",
        "42804205",
        "42768327",
        "42769711",
        "42688822",
        "42727204",
        "42732542",
        "42766673",
        "42721112",
        "42841964",
        "42871667",
        "42863798",
        "42702788",
        "42787626",
        "42873387",
        "42670051",
        "42696532",
        "42797287",
        "42729560",
        "42769822",
        "42766849",
        "42729848",
        "42726702",
        "42710021",
        "42837291",
        "42680780",
        "42840913",
        "42765892",
        "42706232",
        "42799588",
        "42695028",
        "42891241",
        "42705027",
        "42723086",
        "42830015",
        "42791907",
        "42692098",
        "42887092",
        "42849015",
        "42739724",
        "42682166",
        "42866044",
        "42892099",
        "42814927",
        "42695158",
        "42663608",
        "42734915",
        "42731592",
        "42815731",
        "42714373",
        "42778763",
        "42686074",
        "42753254",
        "42675332",
        "42764573",
        "42733696",
        "42809770",
        "42756128",
        "42742582",
        "42792385",
        "42796071",
        "42777239",
        "42705422",
        "42701687",
        "42862569",
        "42760705",
        "42746369",
        "42901213",
        "42896217",
        "42754771",
        "42686352",
        "42756839"
      ],
      "non_medline": [
        {
          "id": "PMC13442215",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Predictors of Sexual Dysfunction in Unipolar Depression: A Register-Based Nested Case-Control Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442246",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Prediction of the onset of mood disorders in the offspring of parents with bipolar and major depressive disorders",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444618",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Impact of Remote Patient Monitoring On Major Depressive episode And Bipolar Disorder Treatment Outcomes: EC-102 Randomized Controlled Trial",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1338064",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.07.26364957",
          "title": "Sustained Viral Suppression and its association with Psychiatric Morbidity and Sleep Quality among Older Adults with Human Immunodeficiency Virus: Evidence from a Retrospective Cohort in Ibadan, Nigeria.",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-09",
          "journalTitle": null
        },
        {
          "id": "PMC13442032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy of Probiotic Supplementation with Lactobacillus and Bifidobacterium in Major Depressive Disorder: A Meta-analysis of Randomized Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443874",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy and Safety of Triple Monoamine Reuptake Inhibitors for Major Depressive Disorder: Meta-analysis of Randomised Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1325655",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10859532/v1",
          "title": "Anxiety symptoms and suicidal ideation in adolescents with major depressive disorder and bipolar disorder: the mediating effect of internet addiction",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-23",
          "journalTitle": null
        },
        {
          "id": "PMC13674596",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": "bioRxiv"
        },
        {
          "id": "PMC13441813",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major Depressive Disorder and Patterns of Antidepressant Prescription in Greece: Α Pharmacoepidemiological Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442931",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effect Of Cariprazine On Metabolic Parameters In Patients Living With Major Depressive Disorder: A Systematic Review And Meta-Analysis",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445032",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Association between blood concentration of sertraline and its effectiveness and safety in major depression: exploratory results of the PREDEP-SERT study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556670",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "749. Safety, tolerability, and efficacy data of 60 Hz white light stimulation in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13443595",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Non-communicable disease risk factors in patients with major depressive disorders",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556740",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "214. Magnetic seizure therapy for major depressive disorder: clinical efficacy, safety, and prefrontal activation measured by functional near-infrared spectroscopy",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13443858",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "GLP-1 Agonist As Adjunct To Antidepressants In Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444383",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Reviewing Probiotics’ effects on Major depressive disorders in older adults: a systematic analysis of randomized controlled trails",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442465",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "What Outcomes Matter in Recovery in Depression?: Cross-sectional Sample of Individuals with Major Depressive Disorder in a Diverse, Safety-net Setting",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1320383",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10638348/v1",
          "title": "Neutrophil-related inflammatory activation during medication-overdose suicide attempts in depressive patients: a case-control study with within-subject pre-attempt comparison",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-16",
          "journalTitle": null
        },
        {
          "id": "PMC13556380",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "193. Efficacy and safety of adjunctive lumateperone 42 mg in major depressive disorder: pooled analysis of demographic and clinical subgroups from Phase 3 randomized placebo-controlled trials",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13442284",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Efficacy and Safety of Adjunctive Lumateperone 42 mg in Major Depressive Disorder: A Pooled Analysis of Demographic and Clinical Subgroups from 2 Phase 3 Randomized Placebo-Controlled Trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442414",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Mind the gap: representation and outcomes of individuals with schizophrenia or major depressive disorder not eligible for randomized controlled trials",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441658",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Digital psychiatry in major depression and suicidality: emotion tracking, smart monitoring, and AI-supported care",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PMC13445065",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Bringing cost-effectiveness models to life: AI Replication of a published model of venlafaxine treatment in major depressive disorder using a large language model (LLM)",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1310193",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.29.26361710",
          "title": "The timeline of brain aging in major depression: A prospective study from before first-onset to established illness",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PMC13680482",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Spatiotemporal feature-based investigation of major depressive disorder and emotion recognition using functional near infrared spectroscopy",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-21",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PMC13661943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PPR1336017",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.05.26364655",
          "title": "Accelerated high-capacity 6 mA transcranial direct current stimulation for major depression",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-07",
          "journalTitle": null
        },
        {
          "id": "PMC13556549",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "252. Clinical application of psychedelic-assisted therapy in major depression and addictions",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13442667",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Illness course variables as predictors of efficacy and speed of response to Spravaro in major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13646898",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Correction to ‘Predictive value of biomarker signatures for suicide risk in hospitalised patients with major depressive disorders: A multicentre study in Shanghai’",
          "pubYear": "2026",
          "pubType": "correction; corrected and republished article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-01",
          "journalTitle": "Gen Psychiatr"
        },
        {
          "id": "PMC13442464",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Case Report of an Adolescent with Major Depressive Disorder and Recurrent Suicide Attempts",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13445404",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Transcranial Magnetic Stimulation Efficacy and Future Directions in Major Depressive Disorder: A Comprehensive Review",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441862",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "What routine mental healthcare data could be used to predict response in major depression treatment?",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13601905",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Metabolomic dysregulation in the association between major depressive disorder and chronic pancreatitis: a large prospective cohort study",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Nutr"
        },
        {
          "id": "PMC13442562",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The Neurobiology of Dual Diagnosis: Investigating the Shared Pathophysiology of Alcohol Use Disorder and Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441736",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Clinical Characteristics of Major Depressive Disorder in Children: Experience from the Child Psychiatry Department of Casablanca University",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443003",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effectiveness of Cognitive Remediation in Subjects with Major Depressive Disorder: 3-Month Follow-Up Results of a Multicenter Randomized Controlled Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556678",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "602. Neurobiological subtyping of major depression identifies distinct cardiometabolic risk profiles in UK Biobank",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13442395",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Emotional Cognition in Major Depressive, Bipolar and Borderline Personality Disorder - a Comparative Study of Recognition of Emotion in Auditory and Visual Stimuli",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556506",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "250. Efficacy of adjunctive lumateperone 42 mg treatment across patient-reported depression symptoms in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13445104",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Exploring the association between cognitive performances, early life traumas, and lifetime suicide attempts in Major Depressive Disorder: an analysis of the PROMPT study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556688",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "436. Distinct neural correlates between suicide attempters with major depressive disorder and other psychiatric disorders: a multimodal imaging study",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13664290",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
          "pubYear": null,
          "pubType": "systematic-review; review",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PPR1328972",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10757676/v1",
          "title": "Obsessive–Compulsive Disorder, Major Depressive Disorder, and Gender Dysphoria Complicated by Non-Medical Self-Castration and Subsequent Genital Self-Injury: A Case Report from Sudan",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-28",
          "journalTitle": null
        },
        {
          "id": "PMC13445383",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Polygenic risk indices for schizophrenia, bipolar and major depressive disorder associated with addiction (smoking and alcohol) in the Russian population in patients with schizophrenia or schizophrenia spectrum disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443547",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The efficacy of transcranial direct current stimulation (tDCS) combined with cognitive behavioural therapy for major depressive disorder: a systematic review and meta-analysis of randomised controlled trials.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443721",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Family Matters: The Role of Internalized Stigma in Shaping Burden Across Caregivers and Patients with Major Depression",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1318126",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.08.26362224",
          "title": "Parsing the Functional Heterogeneity of the Psychosis Spectrum: A Clinically Informed Application of Genomic Structural Equation Modeling",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-11",
          "journalTitle": null
        },
        {
          "id": "PMC13443665",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Endogenous Lithium Status in Major Depression: A Retrospective Analysis of EDTA Blood Samples",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442185",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Electroconvulsive Therapy in a Patient with Somatic Symptom Disorder and Major Depression: A Case Report",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444030",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Testosterone reactivity moderates the association between reactive aggression and suicidality in major depression",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13441943",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Distinguishing Major Depression from Bipolar Disorders: DSM-5 Dimensional Model and Depression-related Psychotic Features",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1329344",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.18.26363409",
          "title": "Epigenetic age acceleration is associated with brain connectivity changes and the risk of major depression after trauma",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-28",
          "journalTitle": null
        },
        {
          "id": "PPR1342587",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.11.26365268",
          "title": "Reduced Systemic Homeostatic and Endothelial Protective Capacity in Adolescent Major Depression: Associations with Early-Life Adversity and Clinical Phenotypes",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-13",
          "journalTitle": null
        },
        {
          "id": "PPR1323328",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.18.26363360",
          "title": "Low-Intensity Focused Ultrasound of the Amygdala in Depression and Anxiety: A First-in-Human Active-Controlled Trial",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-20",
          "journalTitle": null
        },
        {
          "id": "PPR1321121",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.1304.v1",
          "title": "Adjunctive Brexpiprazole in Major Depressive Disorder with Inadequate Response to Antidepressants: A Prospective Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-16",
          "journalTitle": null
        },
        {
          "id": "PPR1313405",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-9336932/v1",
          "title": "Depression Treatment Modalities and Correlates Among Adults with Major Depressive Episode and Suicidal Behaviors",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-07",
          "journalTitle": null
        },
        {
          "id": "PPR1346384",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.18.26365736",
          "title": "Dysfunctional Sleep Beliefs and Attitudes in Major Depressive Disorder: Dimensional Associations with Clinical Phenotypes and Gut-Neuroimmune-Metabolic-Oxidative Pathways",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-20",
          "journalTitle": null
        },
        {
          "id": "PPR1309049",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.27.26361547",
          "title": "Epigenetic and Immunometabolic Signatures of Suicidal Behavior in Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PPR1323026",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10742849/v1",
          "title": "Symptom-Based Latent Classes and 1-Month Symptom Severity and Improvement in Major Depressive Disorder: A Retrospective Latent Class Analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-20",
          "journalTitle": null
        },
        {
          "id": "PPR1344460",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10141103/v1",
          "title": "Internet Addiction and Non-Suicidal Self-Injury in Adolescents with Major Depressive Disorder: The Sequential Mediating Roles of Insomnia and Depressive Symptoms",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-18",
          "journalTitle": null
        },
        {
          "id": "PPR1331786",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.28.26364141",
          "title": "Transdiagnostic metabolic architecture across major depressive disorder and schizophrenia: a NIMETOX systems-biology approach",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-29",
          "journalTitle": null
        },
        {
          "id": "PPR1315197",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.03.26362170",
          "title": "Who Is Reached by Supervised Psilocybin Services? Oregon Services Versus National Psilocybin Use",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-07",
          "journalTitle": null
        },
        {
          "id": "PPR1343271",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.10.14.759202",
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": null
        },
        {
          "id": "PPR1340375",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-11194275/v1",
          "title": "Sex-dependent differences in matrix metalloproteinase-9 and inflammatory markers in postmortem brain of depressed subjects: Effect of pharmacological treatment and suicide",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-14",
          "journalTitle": null
        },
        {
          "id": "PPR1319526",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10822676/v1",
          "title": "Altered Serum Lipid and Amino Acid Metabolism in First-Episode Treatment-Naïve Major Depressive Disorder: A UHPLC-Q-TOF-MS Metabolomics Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-15",
          "journalTitle": null
        },
        {
          "id": "PPR1336428",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.0247.v1",
          "title": "Neurobiological Mechanisms of Mental Disorders in Relation to Epilepsy: A Narrative Review",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-05",
          "journalTitle": null
        },
        {
          "id": "PPR1339601",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.1127.v1",
          "title": "What Epidemiological Studies Tell Us About Depression Among Black Populations?",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-13",
          "journalTitle": null
        },
        {
          "id": "PPR1314413",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10907540/v1",
          "title": "Neuropsychiatric Adverse-Event Reporting With Brexpiprazole Across Approved Indications: A Disproportionality Analysis Using the FDA Adverse Event Reporting System (FAERS)",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-08",
          "journalTitle": null
        },
        {
          "id": "PPR1320038",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.09.13.26362400",
          "title": "Cumulative Indicators of Circadian Rhythm Disturbance and its Clinical, Functional and Genetic Correlates in the Brisbane Longitudinal Twin Study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-14",
          "journalTitle": null
        },
        {
          "id": "PPR1319853",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10779463/v1",
          "title": "Disrupted brain network connectivity associated with the endogenous risk trait of impulsivity in depressive disorder: A network-based statistic study",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-15",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "guidelines",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (guideline OR consensus OR recommendation*) AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 86,
      "fetched": 86,
      "medline_count": 73,
      "pmids": [
        "42756843",
        "42758600",
        "42448624",
        "42812643",
        "42774912",
        "42658027",
        "42814927",
        "42753254",
        "42806848",
        "42550483",
        "42894373",
        "42739877",
        "42736557",
        "42797527",
        "42689366",
        "42735274",
        "42783499",
        "42707775",
        "42766019",
        "42766497",
        "42792438",
        "42630054",
        "42756688",
        "42789363",
        "42737858",
        "42795740",
        "42707709",
        "42815877",
        "42801835",
        "42769949",
        "42805662",
        "42729906",
        "42884023",
        "42613180",
        "42682977",
        "42696738",
        "42663293",
        "30725910",
        "42784817",
        "42796411",
        "42756176",
        "42670051",
        "42675468",
        "42766849",
        "42792450",
        "42726702",
        "42745799",
        "42616023",
        "42761770",
        "42695028",
        "42598999",
        "42698177",
        "42734915",
        "42815884",
        "42788073",
        "42682166",
        "42717325",
        "42777239",
        "42721112",
        "42830939",
        "42850904",
        "42813034",
        "42676104",
        "42792385",
        "42729184",
        "42701687",
        "42804205",
        "42796071",
        "42832766",
        "42710021",
        "42684674",
        "42895746",
        "42686352"
      ],
      "non_medline": [
        {
          "id": "PMC13443727",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Lithium Prescription in Unipolar Depression: Findings from a Nationwide Greek Cohort Study",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442395",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Emotional Cognition in Major Depressive, Bipolar and Borderline Personality Disorder - a Comparative Study of Recognition of Emotion in Auditory and Visual Stimuli",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556678",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "602. Neurobiological subtyping of major depression identifies distinct cardiometabolic risk profiles in UK Biobank",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PPR1310193",
          "source": "PPR",
          "pmid": null,
          "doi": "10.64898/2026.08.29.26361710",
          "title": "The timeline of brain aging in major depression: A prospective study from before first-onset to established illness",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "Y",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-08-31",
          "journalTitle": null
        },
        {
          "id": "PMC13674596",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
          "pubYear": "2026",
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-15",
          "journalTitle": "bioRxiv"
        },
        {
          "id": "PMC13442562",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The Neurobiology of Dual Diagnosis: Investigating the Shared Pathophysiology of Alcohol Use Disorder and Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444738",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depressive disorders related to Post-traumatic cases in Geriatic Patients with traumatic brain Injuries",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444423",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Major depressive disorders related to Post-traumatic cases after cervical spine injuries in amateur athletes",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13608885",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The expressions and m6A methylation modification patterns of mRNAs and lncRNAs in major depressive disorder",
          "pubYear": null,
          "pubType": "research-article; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-25",
          "journalTitle": "Front Genet"
        },
        {
          "id": "PMC13664290",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
          "pubYear": null,
          "pubType": "systematic-review; review",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Psychiatry"
        },
        {
          "id": "PPR1335165",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31222/osf.io/ctbzg_v1",
          "title": "Improving causal inference in neighbourhood-health research by applying target trial emulation to relocation data",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-06",
          "journalTitle": null
        },
        {
          "id": "PPR1313205",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.0433.v1",
          "title": "From Needs Assessment to Pre-Trial Specification: Participatory Co-Design of a Generative AI Chatbot (CARES-MDD) for Persons Living with Depression in Hong Kong Psychiatric Care",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-07",
          "journalTitle": null
        },
        {
          "id": "PPR1331512",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/6f48v_v2",
          "title": "Digital Twins in Mental Health Care: A Qualitative Study on Subjective Relevance, Acceptability and Implementation Considerations Co-Designed, Co-Produced and Co-Written with Experts by Experience and Academics",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-30",
          "journalTitle": null
        }
      ]
    },
    {
      "topic": "patient-experience",
      "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND (\"lived experience\" OR \"patient perspective\" OR \"patient reported\" OR stigma OR \"shared decision\" OR \"treatment burden\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-22]",
      "http": 200,
      "hitCount": 69,
      "fetched": 69,
      "medline_count": 54,
      "pmids": [
        "42742617",
        "42682166",
        "42830726",
        "42901397",
        "42799462",
        "42710021",
        "42799722",
        "42832644",
        "42842074",
        "42778211",
        "42766497",
        "42794499",
        "42811249",
        "42819210",
        "30855854",
        "42792450",
        "42878501",
        "42766849",
        "42663608",
        "42879916",
        "42693223",
        "42701679",
        "42658027",
        "42748866",
        "42901213",
        "42716055",
        "42710412",
        "42783499",
        "42688558",
        "42721198",
        "42878230",
        "42850904",
        "42684674",
        "42726702",
        "42767626",
        "42695028",
        "42784817",
        "42766673",
        "42901970",
        "42739724",
        "42682977",
        "42696738",
        "42830939",
        "42799588",
        "42756843",
        "42796411",
        "42701687",
        "42663293",
        "42805662",
        "42777239",
        "42686352",
        "42754771",
        "42698078",
        "42756839"
      ],
      "non_medline": [
        {
          "id": "PMC13444613",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Clinical Validation of Patient-Reported Cognitive Assessment Tools for Adverse Effects of Electroconvulsive Therapy in Patients with Unipolar Depression",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13443721",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Family Matters: The Role of Internalized Stigma in Shaping Burden Across Caregivers and Patients with Major Depression",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444869",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Breaking Barriers: Exploring New Treatment Approaches for Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13442931",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Effect Of Cariprazine On Metabolic Parameters In Patients Living With Major Depressive Disorder: A Systematic Review And Meta-Analysis",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13556506",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "250. Efficacy of adjunctive lumateperone 42 mg treatment across patient-reported depression symptoms in major depressive disorder",
          "pubYear": "2026",
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-01",
          "journalTitle": "Int J Neuropsychopharmacol"
        },
        {
          "id": "PMC13442562",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The Neurobiology of Dual Diagnosis: Investigating the Shared Pathophysiology of Alcohol Use Disorder and Major Depressive Disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1328972",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10757676/v1",
          "title": "Obsessive–Compulsive Disorder, Major Depressive Disorder, and Gender Dysphoria Complicated by Non-Medical Self-Castration and Subsequent Genital Self-Injury: A Case Report from Sudan",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-28",
          "journalTitle": null
        },
        {
          "id": "PMC13444688",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Predictive value of C-reactive Protein for antidepressant treatment response in patients with major depressive disorder",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13444618",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Impact of Remote Patient Monitoring On Major Depressive episode And Bipolar Disorder Treatment Outcomes: EC-102 Randomized Controlled Trial",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PMC13659288",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
          "pubYear": null,
          "pubType": "review-article; review; journal article",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-10-16",
          "journalTitle": "Front Integr Neurosci"
        },
        {
          "id": "PMC13443547",
          "source": "PMC",
          "pmid": null,
          "doi": null,
          "title": "The efficacy of transcranial direct current stimulation (tDCS) combined with cognitive behavioural therapy for major depressive disorder: a systematic review and meta-analysis of randomised controlled trials.",
          "pubYear": null,
          "pubType": "abstract",
          "isOpenAccess": "Y",
          "inEPMC": "Y",
          "inPMC": "Y",
          "firstPublicationDate": "2026-09-04",
          "journalTitle": "Eur Psychiatry"
        },
        {
          "id": "PPR1313205",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202609.0433.v1",
          "title": "From Needs Assessment to Pre-Trial Specification: Participatory Co-Design of a Generative AI Chatbot (CARES-MDD) for Persons Living with Depression in Hong Kong Psychiatric Care",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-07",
          "journalTitle": null
        },
        {
          "id": "PPR1331512",
          "source": "PPR",
          "pmid": null,
          "doi": "10.31234/osf.io/6f48v_v2",
          "title": "Digital Twins in Mental Health Care: A Qualitative Study on Subjective Relevance, Acceptability and Implementation Considerations Co-Designed, Co-Produced and Co-Written with Experts by Experience and Academics",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-30",
          "journalTitle": null
        },
        {
          "id": "PPR1313590",
          "source": "PPR",
          "pmid": null,
          "doi": "10.21203/rs.3.rs-10504174/v1",
          "title": "Examining Mental Health Literacy among Iranian Teachers through Item Level Analysis",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-09-07",
          "journalTitle": null
        },
        {
          "id": "PPR1339601",
          "source": "PPR",
          "pmid": null,
          "doi": "10.20944/preprints202610.1127.v1",
          "title": "What Epidemiological Studies Tell Us About Depression Among Black Populations?",
          "pubYear": "2026",
          "pubType": "preprint",
          "isOpenAccess": "N",
          "inEPMC": "N",
          "inPMC": "N",
          "firstPublicationDate": "2026-10-13",
          "journalTitle": null
        }
      ]
    }
  ],
  "europe_pmc_non_medline": {
    "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-22] NOT (SRC:MED)",
    "http": 200,
    "hitCount": 194,
    "fetched": 194,
    "records": [
      {
        "id": "PMC13443727",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Lithium Prescription in Unipolar Depression: Findings from a Nationwide Greek Cohort Study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442215",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Predictors of Sexual Dysfunction in Unipolar Depression: A Register-Based Nested Case-Control Study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13444613",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Clinical Validation of Patient-Reported Cognitive Assessment Tools for Adverse Effects of Electroconvulsive Therapy in Patients with Unipolar Depression",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PPR1310193",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.08.29.26361710",
        "title": "The timeline of brain aging in major depression: A prospective study from before first-onset to established illness",
        "pubType": "preprint",
        "firstPublicationDate": "2026-08-31",
        "journalTitle": null
      },
      {
        "id": "PMC13659288",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Neurobiological mechanisms and brain network dysfunction in major depressive disorder: an integrative review",
        "pubType": "review-article; review; journal article",
        "firstPublicationDate": "2026-10-16",
        "journalTitle": "Front Integr Neurosci"
      },
      {
        "id": "PMC13674596",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
        "pubType": "research-article; journal article",
        "firstPublicationDate": "2026-10-15",
        "journalTitle": "bioRxiv"
      },
      {
        "id": "PMC13680482",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Spatiotemporal feature-based investigation of major depressive disorder and emotion recognition using functional near infrared spectroscopy",
        "pubType": "research-article; journal article",
        "firstPublicationDate": "2026-10-21",
        "journalTitle": "Front Psychiatry"
      },
      {
        "id": "PMC13661943",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Resting-state functional connectivity of hippocampal subregions in predicting escitalopram treatment outcome in major depressive disorder",
        "pubType": "research-article; journal article",
        "firstPublicationDate": "2026-10-16",
        "journalTitle": "Front Psychiatry"
      },
      {
        "id": "PMC13643535",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Machine learning classification of fNIRS signals in patients with major depressive disorder and healthy controls",
        "pubType": "research-article; journal article",
        "firstPublicationDate": "2026-10-08",
        "journalTitle": "Front Psychiatry"
      },
      {
        "id": "PMC13664290",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Large-scale brain network modulation by auricular vagus neuromodulation in major depressive disorder: a systematic review of neuroimaging evidence",
        "pubType": "systematic-review; review",
        "firstPublicationDate": "2026-10-16",
        "journalTitle": "Front Psychiatry"
      },
      {
        "id": "PMC13608885",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "The expressions and m6A methylation modification patterns of mRNAs and lncRNAs in major depressive disorder",
        "pubType": "research-article; journal article",
        "firstPublicationDate": "2026-09-25",
        "journalTitle": "Front Genet"
      },
      {
        "id": "PMC13556758",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "70. Desvenlafaxine in the treatment of major depressive disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13601905",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Metabolomic dysregulation in the association between major depressive disorder and chronic pancreatitis: a large prospective cohort study",
        "pubType": "research-article; journal article",
        "firstPublicationDate": "2026-09-25",
        "journalTitle": "Front Nutr"
      },
      {
        "id": "PMC13646898",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Correction to ‘Predictive value of biomarker signatures for suicide risk in hospitalised patients with major depressive disorders: A multicentre study in Shanghai’",
        "pubType": "correction; corrected and republished article",
        "firstPublicationDate": "2026-10-01",
        "journalTitle": "Gen Psychiatr"
      },
      {
        "id": "PMC13443595",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Non-communicable disease risk factors in patients with major depressive disorders",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13444869",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Breaking Barriers: Exploring New Treatment Approaches for Major Depressive Disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442464",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Case Report of an Adolescent with Major Depressive Disorder and Recurrent Suicide Attempts",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13441813",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Major Depressive Disorder and Patterns of Antidepressant Prescription in Greece: Α Pharmacoepidemiological Study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442246",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Prediction of the onset of mood disorders in the offspring of parents with bipolar and major depressive disorders",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13443006",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Return to work after major depressive disorder: predictive factors and reintegration strategies",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442470",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "An algorithmic approach in cases of dual diagnosis - gaming disorder and major depressive disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13556814",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "220. Increased preference transitivity as a marker of cognitive rigidity in major depressive disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13445404",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Transcranial Magnetic Stimulation Efficacy and Future Directions in Major Depressive Disorder: A Comprehensive Review",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442667",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Illness course variables as predictors of efficacy and speed of response to Spravaro in major depressive disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442409",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Patient and Family Determinants of Caregiver Burden in Major Depressive Disorder: A Multicenter Observational Study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442562",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "The Neurobiology of Dual Diagnosis: Investigating the Shared Pathophysiology of Alcohol Use Disorder and Major Depressive Disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13444688",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Predictive value of C-reactive Protein for antidepressant treatment response in patients with major depressive disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13444738",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Major depressive disorders related to Post-traumatic cases in Geriatic Patients with traumatic brain Injuries",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13556582",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "249. A head-to-head comparison of two biologically-based subtyping solutions for major depressive disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556391",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "217. SSVEP as a physiological biomarker of attentional bias and treatment response in adolescent Major Depressive Disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556773",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "306. Genetic and neuroimaging correlates of symptom severity in major depressive disorder: an imaging–genetics study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556786",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "230. LSD microdosing for depression: hype or hope? A randomised controlled trial in major depressive disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13442931",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Effect Of Cariprazine On Metabolic Parameters In Patients Living With Major Depressive Disorder: A Systematic Review And Meta-Analysis",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13441736",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Clinical Characteristics of Major Depressive Disorder in Children: Experience from the Child Psychiatry Department of Casablanca University",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442414",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Mind the gap: representation and outcomes of individuals with schizophrenia or major depressive disorder not eligible for randomized controlled trials",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13444383",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Reviewing Probiotics’ effects on Major depressive disorders in older adults: a systematic analysis of randomized controlled trails",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13444423",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Major depressive disorders related to Post-traumatic cases after cervical spine injuries in amateur athletes",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442657",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Association Between Childhood Neglect and Major Depressive Disorder: A Systematic Review, Meta-Analysis and Meta-Regression",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442032",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Efficacy of Probiotic Supplementation with Lactobacillus and Bifidobacterium in Major Depressive Disorder: A Meta-analysis of Randomized Controlled Trials",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13556833",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "780. Classification of Major Depressive Disorder Subtypes via Surface-based Brain Imaging and Clinical Features",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556670",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "749. Safety, tolerability, and efficacy data of 60 Hz white light stimulation in major depressive disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13443874",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Efficacy and Safety of Triple Monoamine Reuptake Inhibitors for Major Depressive Disorder: Meta-analysis of Randomised Controlled Trials",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13556365",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "218. miR-221-3p mediates electroconvulsive therapy’s mechanisms in adolescent major depressive disorder: a translational study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556752",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "816. Frontal structural network vulnerability and peripheral immune dysregulation in major depressive disorder: diagnostic and prognostic implications",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556590",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "242. The effect of childhood trauma on drug resistance in major depressive disorder - results from the international PROMPT study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556705",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "489. Task-based fMRI investigation of neural changes following acceptance and commitment therapy in major depressive disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556701",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "355. PPARγ as a predictive biomarker for antidepressant response in major depressive disorder: insights from TNIP1 transcriptional regulation",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13441991",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Genome-Wide DNA Methylation Analysis Reveals Epigenetic Signatures of Early Life Stress in Major Depressive Disorder Patients",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442395",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Emotional Cognition in Major Depressive, Bipolar and Borderline Personality Disorder - a Comparative Study of Recognition of Emotion in Auditory and Visual Stimuli",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13443858",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "GLP-1 Agonist As Adjunct To Antidepressants In Patients With Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial.",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13556506",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "250. Efficacy of adjunctive lumateperone 42 mg treatment across patient-reported depression symptoms in major depressive disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556358",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "587. Female-specific role of interleukin 6 and C-reactive protein in individuals with major depressive disorder and comorbid obesity",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556626",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "365. Association between CYP2D6 genotype and treatment outcomes in hospitalized patients with major depressive disorder: a retrospective cohort study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13442465",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "What Outcomes Matter in Recovery in Depression?: Cross-sectional Sample of Individuals with Major Depressive Disorder in a Diverse, Safety-net Setting",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13443003",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Effectiveness of Cognitive Remediation in Subjects with Major Depressive Disorder: 3-Month Follow-Up Results of a Multicenter Randomized Controlled Study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13444618",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Impact of Remote Patient Monitoring On Major Depressive episode And Bipolar Disorder Treatment Outcomes: EC-102 Randomized Controlled Trial",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13556688",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "436. Distinct neural correlates between suicide attempters with major depressive disorder and other psychiatric disorders: a multimodal imaging study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556682",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "487. Genome-wide DNA methylation analysis reveals epigenetic signatures of early life stress in major depressive disorder patients",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13445104",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Exploring the association between cognitive performances, early life traumas, and lifetime suicide attempts in Major Depressive Disorder: an analysis of the PROMPT study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13556740",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "214. Magnetic seizure therapy for major depressive disorder: clinical efficacy, safety, and prefrontal activation measured by functional near-infrared spectroscopy",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556394",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "363. Angular gyrus as a key hub of treatment refractoriness and neuromodulation response in major depressive disorder: a data-driven structural covariance network analysis",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13445383",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Polygenic risk indices for schizophrenia, bipolar and major depressive disorder associated with addiction (smoking and alcohol) in the Russian population in patients with schizophrenia or schizophrenia spectrum disorder",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13445065",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Bringing cost-effectiveness models to life: AI Replication of a published model of venlafaxine treatment in major depressive disorder using a large language model (LLM)",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13556477",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "290. Plasma neurofilament light chain levels in drug-free patients with major depressive disorder and changes after antidepressant treatment: a longitudinal pilot study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13441644",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Bidirectional Associations Between Highly Processed Food Consumption and Major Depressive Disorder: A Cross-Sectional Study on Adults Residing in Madrid and Barcelona (Edad con Salud)",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13443547",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "The efficacy of transcranial direct current stimulation (tDCS) combined with cognitive behavioural therapy for major depressive disorder: a systematic review and meta-analysis of randomised controlled trials.",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13556810",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "439. Polygenic stratification reveals differential response to V1b antagonism in pre-exposed patients with major depressive disorder: a post-hoc analysis of the phase 2 OLIVE trial",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13442284",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Efficacy and Safety of Adjunctive Lumateperone 42 mg in Major Depressive Disorder: A Pooled Analysis of Demographic and Clinical Subgroups from 2 Phase 3 Randomized Placebo-Controlled Trials",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13556380",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "193. Efficacy and safety of adjunctive lumateperone 42 mg in major depressive disorder: pooled analysis of demographic and clinical subgroups from Phase 3 randomized placebo-controlled trials",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13556549",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "252. Clinical application of psychedelic-assisted therapy in major depression and addictions",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13443665",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Endogenous Lithium Status in Major Depression: A Retrospective Analysis of EDTA Blood Samples",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13442185",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Electroconvulsive Therapy in a Patient with Somatic Symptom Disorder and Major Depression: A Case Report",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13444030",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Testosterone reactivity moderates the association between reactive aggression and suicidality in major depression",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13441626",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Postoperative Catatonia in a Patient with Major Depression: A Case Report Following Orthognathic Surgery",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13444050",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Major depression and glucidic metabolism: a prospective assessment of response to treatment with antidepressant drugs",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13443721",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Family Matters: The Role of Internalized Stigma in Shaping Burden Across Caregivers and Patients with Major Depression",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13441658",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Digital psychiatry in major depression and suicidality: emotion tracking, smart monitoring, and AI-supported care",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13444959",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Predicting rTMS Treatment Response in Major Depression Using Minimal-Electrode EEG and Machine Learning",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13441862",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "What routine mental healthcare data could be used to predict response in major depression treatment?",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PMC13556678",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "602. Neurobiological subtyping of major depression identifies distinct cardiometabolic risk profiles in UK Biobank",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": "Int J Neuropsychopharmacol"
      },
      {
        "id": "PMC13441943",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Distinguishing Major Depression from Bipolar Disorders: DSM-5 Dimensional Model and Depression-related Psychotic Features",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PPR1318221",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.09.26362608",
        "title": "A Systems Biology Model Linking Peripheral NIMETOX Biomarkers to Multilevel Brain Structural and Functional Alterations Across Major Depression and Schizophrenia",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-11",
        "journalTitle": null
      },
      {
        "id": "PPR1337537",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-11109337/v1",
        "title": "Self-Organizing Immune-Inflammatory Architectures in Severe Major Depression: Higher- Order Interactivity and Viral Pathogenesis",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-09",
        "journalTitle": null
      },
      {
        "id": "PMC13445032",
        "source": "PMC",
        "pmid": null,
        "doi": null,
        "title": "Association between blood concentration of sertraline and its effectiveness and safety in major depression: exploratory results of the PREDEP-SERT study",
        "pubType": "abstract",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": "Eur Psychiatry"
      },
      {
        "id": "PPR1336017",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.05.26364655",
        "title": "Accelerated high-capacity 6 mA transcranial direct current stimulation for major depression",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-07",
        "journalTitle": null
      },
      {
        "id": "PPR1342587",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.11.26365268",
        "title": "Reduced Systemic Homeostatic and Endothelial Protective Capacity in Adolescent Major Depression: Associations with Early-Life Adversity and Clinical Phenotypes",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-13",
        "journalTitle": null
      },
      {
        "id": "PPR1313962",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.02.26362049",
        "title": "Genetic and epigenetic architecture of mass spectrometry-derived lipids in blood and their role in lifetime Major Depressive Disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-06",
        "journalTitle": null
      },
      {
        "id": "PPR1314594",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10683316/v1",
        "title": "Electroconvulsive therapy modulates neurite density and free water in discrete white matter compartments in major depression",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-08",
        "journalTitle": null
      },
      {
        "id": "PPR1329344",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.18.26363409",
        "title": "Epigenetic age acceleration is associated with brain connectivity changes and the risk of major depression after trauma",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-28",
        "journalTitle": null
      },
      {
        "id": "PPR1335002",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10948059/v1",
        "title": "Cross-tissue integrative transcriptomics identifies peripheral blood biomarkers associated with the neuroimmune molecular landscape in major depressive disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-06",
        "journalTitle": null
      },
      {
        "id": "PPR1333678",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10879308/v1",
        "title": "Therapists’ Perspectives on the Psychotherapeutic Support in Psilocybin Treatment for Major Depressive Disorder: Insights from a Randomized Controlled Trial",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-05",
        "journalTitle": null
      },
      {
        "id": "PPR1333312",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.28.754910",
        "title": "Temporal organization of shared brain states characterizes heterogeneity in major depressive disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-02",
        "journalTitle": null
      },
      {
        "id": "PPR1317138",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10597420/v1",
        "title": "Escalating intimate partner violence and depression following resettlement among Tamil speaking Sri Lankan women from refugee-background: A longitudinal Australian cohort study. ",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-11",
        "journalTitle": null
      },
      {
        "id": "PPR1315605",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-9633682/v1",
        "title": "Case Report: Grade 2 oligodendroglioma presenting as treatment resistant major depressive disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-09",
        "journalTitle": null
      },
      {
        "id": "PPR1341989",
        "source": "PPR",
        "pmid": null,
        "doi": "10.31234/osf.io/kzsmp_v1",
        "title": "Effects of a Web-Based Debiasing Intervention on Brazilian Psychologists’ Accuracy on Major Depressive Disorder Diagnostic Tasks: A Randomized Training Intervention",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-12",
        "journalTitle": null
      },
      {
        "id": "PPR1346357",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.18.26365862",
        "title": "Shared Social Brain Gray Matter Reductions in Depression, Schizophrenia, and Alcohol Use Disorder: A Meta-Analysis",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-20",
        "journalTitle": null
      },
      {
        "id": "PPR1329762",
        "source": "PPR",
        "pmid": null,
        "doi": "10.20944/preprints202609.2452.v1",
        "title": "Voided REM Sleep (V-REM): A Candidate Biomarker Linking Treatment-Resistant PTSD and Major Depressive Disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-29",
        "journalTitle": null
      },
      {
        "id": "PPR1313405",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-9336932/v1",
        "title": "Depression Treatment Modalities and Correlates Among Adults with Major Depressive Episode and Suicidal Behaviors",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-07",
        "journalTitle": null
      },
      {
        "id": "PPR1323246",
        "source": "PPR",
        "pmid": null,
        "doi": "10.31234/osf.io/u72y4_v1",
        "title": "Genetic Evidence Linking Prefrontal Surface Area to ADHD, Major Depression, and Smoking Initiation",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-20",
        "journalTitle": null
      },
      {
        "id": "PPR1336698",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-7349413/v1",
        "title": "Profiling Transcriptomic Changes Across Frontal Cortical Subregions in Major Depressive Disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-08",
        "journalTitle": null
      },
      {
        "id": "PPR1347340",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.18.26365850",
        "title": "Association of neurotransmitter-based polygenic scores with antidepressant treatment outcomes in patients with major depressive disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-21",
        "journalTitle": null
      },
      {
        "id": "PPR1317739",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.08.26362568",
        "title": "Human genetic risk for major depressive disorder implicates motor cortex PVALB⁺ inhibitory neurons",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-10",
        "journalTitle": null
      },
      {
        "id": "PPR1328972",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10757676/v1",
        "title": "Obsessive–Compulsive Disorder, Major Depressive Disorder, and Gender Dysphoria Complicated by Non-Medical Self-Castration and Subsequent Genital Self-Injury: A Case Report from Sudan",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-28",
        "journalTitle": null
      },
      {
        "id": "PPR1313556",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-9885081/v1",
        "title": "Adolescent subthreshold depression: Prevalence, risk factors, and transition to major depressive disorder: A systematic review and meta-analysis",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-07",
        "journalTitle": null
      },
      {
        "id": "PPR1344134",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.12.26365369",
        "title": "Attenuated GlycoRNA-microglial transcriptional coupling in the dorsolateral prefrontal cortex of patients with major depressive disorder: an exploratory interaction-based in-silico analysis",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-15",
        "journalTitle": null
      },
      {
        "id": "PPR1340721",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-8177826/v1",
        "title": "Cellular senescence changes and their association with brain structure in schizophrenia and major depressive disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-14",
        "journalTitle": null
      },
      {
        "id": "PPR1342227",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.13.26365398",
        "title": "Not just harder: Compression of perceived effort in major depressive disorder is associated with symptom burden and altered decision-making",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-14",
        "journalTitle": null
      },
      {
        "id": "PPR1340792",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-11097214/v1",
        "title": "Beyond Gray Matter: White Matter Functional Network Signatures of Major Depressive Disorder Track Symptom Severity",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-14",
        "journalTitle": null
      },
      {
        "id": "PPR1309049",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.08.27.26361547",
        "title": "Epigenetic and Immunometabolic Signatures of Suicidal Behavior in Major Depressive Disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-08-31",
        "journalTitle": null
      },
      {
        "id": "PPR1338064",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.07.26364957",
        "title": "Sustained Viral Suppression and its association with Psychiatric Morbidity and Sleep Quality among Older Adults with Human Immunodeficiency Virus: Evidence from a Retrospective Cohort in Ibadan, Nigeria.",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-09",
        "journalTitle": null
      },
      {
        "id": "PPR1336028",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.06.26364759",
        "title": "Neuroplasticity-Based Treatment Prioritization in Major Depressive Disorder: A Two-Cohort Study",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-07",
        "journalTitle": null
      },
      {
        "id": "PPR1321262",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10861845/v1",
        "title": "Baseline subgenual cingulate functional connectivity does not predict symptom-dimension-specific improvement during escitalopram treatment in major depressive disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-17",
        "journalTitle": null
      },
      {
        "id": "PPR1346384",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.18.26365736",
        "title": "Dysfunctional Sleep Beliefs and Attitudes in Major Depressive Disorder: Dimensional Associations with Clinical Phenotypes and Gut-Neuroimmune-Metabolic-Oxidative Pathways",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-20",
        "journalTitle": null
      },
      {
        "id": "PPR1342658",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.06.757042",
        "title": "Dual Roles of Interferon-γ Receptor in Somatostatin Interneurons at Baseline and During",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-13",
        "journalTitle": null
      },
      {
        "id": "PPR1325655",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10859532/v1",
        "title": "Anxiety symptoms and suicidal ideation in adolescents with major depressive disorder and bipolar disorder: the mediating effect of internet addiction",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-23",
        "journalTitle": null
      },
      {
        "id": "PPR1323026",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10742849/v1",
        "title": "Symptom-Based Latent Classes and 1-Month Symptom Severity and Improvement in Major Depressive Disorder: A Retrospective Latent Class Analysis",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-20",
        "journalTitle": null
      },
      {
        "id": "PPR1322092",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10858262/v1",
        "title": "Symptom-level associations of immuno-metabolic indices in major depressive disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-18",
        "journalTitle": null
      },
      {
        "id": "PPR1321121",
        "source": "PPR",
        "pmid": null,
        "doi": "10.20944/preprints202609.1304.v1",
        "title": "Adjunctive Brexpiprazole in Major Depressive Disorder with Inadequate Response to Antidepressants: A Prospective Study",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-16",
        "journalTitle": null
      },
      {
        "id": "PPR1344460",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10141103/v1",
        "title": "Internet Addiction and Non-Suicidal Self-Injury in Adolescents with Major Depressive Disorder: The Sequential Mediating Roles of Insomnia and Depressive Symptoms",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-18",
        "journalTitle": null
      },
      {
        "id": "PPR1317194",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10823532/v1",
        "title": "Automatic detection of depression in clinical interviews with large language models",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-11",
        "journalTitle": null
      },
      {
        "id": "PPR1331786",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.28.26364141",
        "title": "Transdiagnostic metabolic architecture across major depressive disorder and schizophrenia: a NIMETOX systems-biology approach",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-29",
        "journalTitle": null
      },
      {
        "id": "PPR1317770",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.08.26362462",
        "title": "Effects of sex, treatment resistance, and antidepressant treatment on monoamine oxidase B total distribution volume",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-10",
        "journalTitle": null
      },
      {
        "id": "PPR1335165",
        "source": "PPR",
        "pmid": null,
        "doi": "10.31222/osf.io/ctbzg_v1",
        "title": "Improving causal inference in neighbourhood-health research by applying target trial emulation to relocation data",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-06",
        "journalTitle": null
      },
      {
        "id": "PPR1317510",
        "source": "PPR",
        "pmid": null,
        "doi": "10.31234/osf.io/d7bc2_v1",
        "title": "Combined sleep deprivation and light therapy for depression in major depressive disorder and bipolar disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-11",
        "journalTitle": null
      },
      {
        "id": "PPR1310996",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.08.28.26361493",
        "title": "<i>In Vitro</i>  Ketamine Attenuates Immune Sensitization in Major Depressive Disorder in a Concentration-Dependent Manner",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-02",
        "journalTitle": null
      },
      {
        "id": "PPR1308902",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.08.25.26361081",
        "title": "Adjunctive Psychobiotic  <i>Lactiplantibacillus plantarum</i>  PS128 Therapy and Escitalopram in Major Depressive Disorder: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial",
        "pubType": "preprint",
        "firstPublicationDate": "2026-08-31",
        "journalTitle": null
      },
      {
        "id": "PPR1331666",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.29.26364222",
        "title": "A rare-variant analysis of  <i>FADS</i>  -related metabolites in Major Depression",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-29",
        "journalTitle": null
      },
      {
        "id": "PPR1328587",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.25.26363706",
        "title": "A founder population reveals genetic variation with major effect on serious mental illness",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-27",
        "journalTitle": null
      },
      {
        "id": "PPR1323328",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.18.26363360",
        "title": "Low-Intensity Focused Ultrasound of the Amygdala in Depression and Anxiety: A First-in-Human Active-Controlled Trial",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-20",
        "journalTitle": null
      },
      {
        "id": "PPR1343271",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.14.759202",
        "title": "Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-15",
        "journalTitle": null
      },
      {
        "id": "PPR1345206",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.16.26365761",
        "title": "The stuff that dreams are made of: Genomics and biology of nightmares",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-19",
        "journalTitle": null
      },
      {
        "id": "PPR1308951",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.08.25.26361076",
        "title": "Multiday rhythms shape mood dynamics in depression",
        "pubType": "preprint",
        "firstPublicationDate": "2026-08-31",
        "journalTitle": null
      },
      {
        "id": "PPR1332894",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.01.26364438",
        "title": "Prefrontal EEG Delta-Beta Coupling Marks Depressed State in Adult Siblings",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-02",
        "journalTitle": null
      },
      {
        "id": "PPR1320866",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.10.750575",
        "title": "Motor learning adapts to effort-dependent uncertainty",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-15",
        "journalTitle": null
      },
      {
        "id": "PPR1311047",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.08.27.746330",
        "title": "Spacing theta-burst stimulation enhances synaptic potentiation in the vulnerable prefrontal cortex",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-01",
        "journalTitle": null
      },
      {
        "id": "PPR1329398",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.26.26364056",
        "title": "Dissecting shared genetic susceptibility between gastroesophageal reflux disease and psychiatric disorders beyond body mass index",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-28",
        "journalTitle": null
      },
      {
        "id": "PPR1330586",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.28.26364187",
        "title": "Cortical hemodynamic dysregulation is linked to peripheral NIMETOX pathways in major depressive disorder: an 89-channel fNIRS systems-biology study",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-29",
        "journalTitle": null
      },
      {
        "id": "PPR1344690",
        "source": "PPR",
        "pmid": null,
        "doi": "10.20944/preprints202610.1646.v1",
        "title": "The Role of Cortisol in CNS Disease –11β-HSD1 Inhibition as a Potential New Therapeutic Strategy for Alzheimer’s Disease and Major Depressive Disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-16",
        "journalTitle": null
      },
      {
        "id": "PPR1343736",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10095364/v1",
        "title": "PCA-MR - A powerful framework for cis-Mendelian Randomization with correlated variants and sparse exposures",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-16",
        "journalTitle": null
      },
      {
        "id": "PPR1319526",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10822676/v1",
        "title": "Altered Serum Lipid and Amino Acid Metabolism in First-Episode Treatment-Naïve Major Depressive Disorder: A UHPLC-Q-TOF-MS Metabolomics Study",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-15",
        "journalTitle": null
      },
      {
        "id": "PPR1340375",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-11194275/v1",
        "title": "Sex-dependent differences in matrix metalloproteinase-9 and inflammatory markers in postmortem brain of depressed subjects: Effect of pharmacological treatment and suicide",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-14",
        "journalTitle": null
      },
      {
        "id": "PPR1342624",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.11.26365174",
        "title": "Discrete cortico-hippocampal circuit states underlie mood state transitions in depression",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-13",
        "journalTitle": null
      },
      {
        "id": "PPR1332815",
        "source": "PPR",
        "pmid": null,
        "doi": "10.31234/osf.io/m24gs_v1",
        "title": "Psychiatric Overdiagnosis as Diagnostic Stretching in Response to Clinical Need",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-02",
        "journalTitle": null
      },
      {
        "id": "PPR1345217",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.16.26364574",
        "title": "Identification of pleiotropic genes and biological mechanisms underlying the shared genetic component between asthma, neuropsychiatric disorders, and substance use behaviors",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-19",
        "journalTitle": null
      },
      {
        "id": "PPR1320354",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10930107/v1",
        "title": "MDD-Explorer: A Multi-scale Visual Evolution Framework for Dynamic Functional Connectivity in Depression",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-16",
        "journalTitle": null
      },
      {
        "id": "PPR1319124",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.08.750125",
        "title": "Multi-Methodological Characterization of Sleep Deprivation: From Standard EEG Power Spectra to Aperiodic Dynamics in Humans and Mice",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-14",
        "journalTitle": null
      },
      {
        "id": "PPR1336428",
        "source": "PPR",
        "pmid": null,
        "doi": "10.20944/preprints202610.0247.v1",
        "title": "Neurobiological Mechanisms of Mental Disorders in Relation to Epilepsy: A Narrative Review",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-05",
        "journalTitle": null
      },
      {
        "id": "PPR1310523",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10739557/v1",
        "title": "Mitochondrial dysfunction in first-episode drug-naïve major depressive disorder: insights from serum non-targeted metabolomics",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-02",
        "journalTitle": null
      },
      {
        "id": "PPR1332876",
        "source": "PPR",
        "pmid": null,
        "doi": "10.14293/pr2199.004576.v1",
        "title": "Voided REM Sleep (V-REM)",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-28",
        "journalTitle": null
      },
      {
        "id": "PPR1328258",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.18.752576",
        "title": "Major depressive disorder recurrence and medication status shape brain network topology",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-24",
        "journalTitle": null
      },
      {
        "id": "PPR1341863",
        "source": "PPR",
        "pmid": null,
        "doi": "10.31234/osf.io/cepxv_v1",
        "title": "Rumination under the microscope: causal discovery and inference of the effect of rumination on depressive symptoms in an N-of-1 time series",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-14",
        "journalTitle": null
      },
      {
        "id": "PPR1339733",
        "source": "PPR",
        "pmid": null,
        "doi": "10.20944/preprints202610.0994.v1",
        "title": "Long-Term Fluoxetine Treatment Alters Fecal Microbiota and Induces Systemic Disruption in Sprague-Dawley Rats",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-12",
        "journalTitle": null
      },
      {
        "id": "PPR1334272",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.30.26363896",
        "title": "Escaping the Negative Attentional Bias in Depression with Real-Time Neurofeedback",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-05",
        "journalTitle": null
      },
      {
        "id": "PPR1312534",
        "source": "PPR",
        "pmid": null,
        "doi": "10.31234/osf.io/c3qbj_v1",
        "title": "Longitudinal computational phenotyping reveals a stable marker for depression symptoms",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-04",
        "journalTitle": null
      },
      {
        "id": "PPR1310173",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.08.26.747253",
        "title": "Every Cure Knowledge Graph: A Unified Biomedical Knowledge Graph for Drug Repurposing",
        "pubType": "preprint",
        "firstPublicationDate": "2026-08-31",
        "journalTitle": null
      },
      {
        "id": "PPR1323803",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10628442/v1",
        "title": "Multi-Feature 3D Deep Learning for Predicting Antidepressant Treatment Response from Structural MRI",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-21",
        "journalTitle": null
      },
      {
        "id": "PPR1343927",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.08.757641",
        "title": "Acute stress reorganizes pregenual cingulate and subthalamic coupling to approach-avoidance decisions in remitted depression",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-16",
        "journalTitle": null
      },
      {
        "id": "PPR1339657",
        "source": "PPR",
        "pmid": null,
        "doi": "10.20944/preprints202610.1070.v1",
        "title": "Does Depression Phenotype Predict Antidepressant Response? A Transdiagnostic Review of Phenotype-Specific Antidepressant Efficacy",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-12",
        "journalTitle": null
      },
      {
        "id": "PPR1318167",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.08.26362080",
        "title": "Chronic sensing during subcallosal cingulate deep brain stimulation captures ketamine-associated changes in major depressive disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-11",
        "journalTitle": null
      },
      {
        "id": "PPR1335135",
        "source": "PPR",
        "pmid": null,
        "doi": "10.31234/osf.io/8wtqx_v4",
        "title": "Empirically derived phenotypes can reduce diagnostic heterogeneity",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-06",
        "journalTitle": null
      },
      {
        "id": "PPR1315197",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.03.26362170",
        "title": "Who Is Reached by Supervised Psilocybin Services? Oregon Services Versus National Psilocybin Use",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-07",
        "journalTitle": null
      },
      {
        "id": "PPR1312842",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.08.29.748003",
        "title": "Postmortem Alterations of Metabotropic Glutamate Receptors across Neuropsychiatric Disorders: A Systematic Review",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-03",
        "journalTitle": null
      },
      {
        "id": "PPR1327123",
        "source": "PPR",
        "pmid": null,
        "doi": "10.31234/osf.io/8wtqx_v3",
        "title": "Empirically derived phenotypes can reduce diagnostic heterogeneity",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-24",
        "journalTitle": null
      },
      {
        "id": "PPR1338899",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.08.757516",
        "title": "Cellular and molecular census of the pleiotropic disease  <i>locus</i>  Negr1 in zebrafish",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-11",
        "journalTitle": null
      },
      {
        "id": "PPR1337148",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.06.26364737",
        "title": "Psychiatric comorbidity in dissociative identity disorder: A meta-analysis",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-07",
        "journalTitle": null
      },
      {
        "id": "PPR1313590",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10504174/v1",
        "title": "Examining Mental Health Literacy among Iranian Teachers through Item Level Analysis",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-07",
        "journalTitle": null
      },
      {
        "id": "PPR1328368",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.24.26363889",
        "title": "Directed effective connectivity between the SCN-containing hypothalamus and pineal gland varies by chronotype in bipolar disorder",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-26",
        "journalTitle": null
      },
      {
        "id": "PPR1344289",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.15.26365624",
        "title": "A clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of psychiatric disorders",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-16",
        "journalTitle": null
      },
      {
        "id": "PPR1341371",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-11106755/v1",
        "title": "Intranasal Human Olfactory Mucosa-Derived Neural Stem Cells Restore Neuroplasticity and Suppress Neuroinflammation in a Rat Model of Chronic Stress-Induced Depression",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-13",
        "journalTitle": null
      },
      {
        "id": "PPR1337427",
        "source": "PPR",
        "pmid": null,
        "doi": "10.20944/preprints202610.0452.v1",
        "title": "The Somnogenesis System: A Proposed Biological System for Psychiatry",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-08",
        "journalTitle": null
      },
      {
        "id": "PPR1342084",
        "source": "PPR",
        "pmid": null,
        "doi": "10.14293/pr2199.004616.v1",
        "title": "The Somnogenesis System",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-05",
        "journalTitle": null
      },
      {
        "id": "PPR1313205",
        "source": "PPR",
        "pmid": null,
        "doi": "10.20944/preprints202609.0433.v1",
        "title": "From Needs Assessment to Pre-Trial Specification: Participatory Co-Design of a Generative AI Chatbot (CARES-MDD) for Persons Living with Depression in Hong Kong Psychiatric Care",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-07",
        "journalTitle": null
      },
      {
        "id": "PPR1335719",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-11053638/v1",
        "title": "Mood Disorder Risk After Pregnancy: A Comparison of Gestational and Pregestational Diabetes",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-07",
        "journalTitle": null
      },
      {
        "id": "PPR1331512",
        "source": "PPR",
        "pmid": null,
        "doi": "10.31234/osf.io/6f48v_v2",
        "title": "Digital Twins in Mental Health Care: A Qualitative Study on Subjective Relevance, Acceptability and Implementation Considerations Co-Designed, Co-Produced and Co-Written with Experts by Experience and Academics",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-30",
        "journalTitle": null
      },
      {
        "id": "PPR1343552",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-11088167/v1",
        "title": "Striatal tissue iron in depressed and healthy individuals and the effect of buproprion",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-16",
        "journalTitle": null
      },
      {
        "id": "PPR1311246",
        "source": "PPR",
        "pmid": null,
        "doi": "10.20944/preprints202609.0237.v1",
        "title": "Choosing Antidepressants When Depression Meets Insomnia: Comparative Efficacy, Sleep Effects, and Sexual-Function Trade-offs—A Narrative Review",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-03",
        "journalTitle": null
      },
      {
        "id": "PPR1310525",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10321561/v1",
        "title": "Perceived Parental Control and Mixed-Feature Symptoms in Student Patients with Depressive Episodes: Associations with Depressive Symptoms and Smartphone Addiction in a Multicenter Study",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-02",
        "journalTitle": null
      },
      {
        "id": "PPR1324601",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10327913/v1",
        "title": "Treatment Resistant Depression: Perspective of Psychiatrists in Saudi Arabia",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-22",
        "journalTitle": null
      },
      {
        "id": "PPR1320383",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10638348/v1",
        "title": "Neutrophil-related inflammatory activation during medication-overdose suicide attempts in depressive patients: a case-control study with within-subject pre-attempt comparison",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-16",
        "journalTitle": null
      },
      {
        "id": "PPR1318126",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.08.26362224",
        "title": "Parsing the Functional Heterogeneity of the Psychosis Spectrum: A Clinically Informed Application of Genomic Structural Equation Modeling",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-11",
        "journalTitle": null
      },
      {
        "id": "PPR1330110",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-9707995/v1",
        "title": "Balancing Utility and Privacy: Evaluating Synthetic Gene Expression Data with a Novel Dilution Metric for Feature Stability",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-29",
        "journalTitle": null
      },
      {
        "id": "PPR1312706",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.01.26361949",
        "title": "Substance Use is Not Associated with Antidepressant Response to Transcranial Magnetic Stimulation",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-03",
        "journalTitle": null
      },
      {
        "id": "PPR1312767",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.08.31.26361809",
        "title": "Molecular Underpinnings of Retinal Traits Shared with Major Psychiatric Disorders",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-03",
        "journalTitle": null
      },
      {
        "id": "PPR1335078",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-11258808/v1",
        "title": "From Suspicion to Syndrome: A Systematic Review on Threat Monitoring, Cognitive Biases, and the Transdiagnostic Trajectory from Fear to Depression within Metacognitive Therapy Frameworks",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-06",
        "journalTitle": null
      },
      {
        "id": "PPR1319853",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10779463/v1",
        "title": "Disrupted brain network connectivity associated with the endogenous risk trait of impulsivity in depressive disorder: A network-based statistic study",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-15",
        "journalTitle": null
      },
      {
        "id": "PPR1332977",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.27.754773",
        "title": "Alignment with sex-typical brain architecture: Links to mood pathology, sex hormones and transcriptomics of neurodegenerative conditions",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-02",
        "journalTitle": null
      },
      {
        "id": "PPR1311324",
        "source": "PPR",
        "pmid": null,
        "doi": "10.20944/preprints202609.0161.v1",
        "title": "Pharmacometabolomics of Psychotropic Drugs: Treatment Response, Adverse Effects, and Precision Psychiatry—A Narrative Review",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-02",
        "journalTitle": null
      },
      {
        "id": "PPR1307554",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10811698/v1",
        "title": "A Multilevel Mechanistic Platform for Antidepressant-Response Prediction Integrating Pharmacokinetics, Polypharmacology, Inflammation, Neuroplasticity, Large-Scale Networks and the Gut–Brain Axis: Chronological Development and Indicator-Level Evaluation Across 51 Drugs and 15 Drug–Nutraceutical Combinations",
        "pubType": "preprint",
        "firstPublicationDate": "2026-08-28",
        "journalTitle": null
      },
      {
        "id": "PPR1317728",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.08.26362466",
        "title": "Lifestyle therapy versus cognitive behavioural therapy for adults with mood disorders: a randomised non-inferiority trial",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-10",
        "journalTitle": null
      },
      {
        "id": "PPR1320038",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.13.26362400",
        "title": "Cumulative Indicators of Circadian Rhythm Disturbance and its Clinical, Functional and Genetic Correlates in the Brisbane Longitudinal Twin Study",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-14",
        "journalTitle": null
      },
      {
        "id": "PPR1317763",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.09.08.26362586",
        "title": "Brain functional dynamics linked to depression and anxiety: cross-sectional and longitudinal associations over 9 years",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-10",
        "journalTitle": null
      },
      {
        "id": "PPR1339601",
        "source": "PPR",
        "pmid": null,
        "doi": "10.20944/preprints202610.1127.v1",
        "title": "What Epidemiological Studies Tell Us About Depression Among Black Populations?",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-13",
        "journalTitle": null
      },
      {
        "id": "PPR1342759",
        "source": "PPR",
        "pmid": null,
        "doi": "10.64898/2026.10.10.26365209",
        "title": "Longitudinal Pain Profiles and Their Clinical and Genetic Correlates in 624,996 U.S. Veterans",
        "pubType": "preprint",
        "firstPublicationDate": "2026-10-12",
        "journalTitle": null
      },
      {
        "id": "PPR1314413",
        "source": "PPR",
        "pmid": null,
        "doi": "10.21203/rs.3.rs-10907540/v1",
        "title": "Neuropsychiatric Adverse-Event Reporting With Brexpiprazole Across Approved Indications: A Disproportionality Analysis Using the FDA Adverse Event Reporting System (FAERS)",
        "pubType": "preprint",
        "firstPublicationDate": "2026-09-08",
        "journalTitle": null
      }
    ]
  },
  "europe_pmc_preprints": {
    "query": "(TITLE_ABS:\"major depression\" OR TITLE_ABS:\"major depressive\" OR TITLE_ABS:\"unipolar depression\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-22] AND SRC:PPR",
    "http": 200,
    "hitCount": 113,
    "fetched": 113,
    "note": "None added. Preprints are not peer-reviewed and none was a landmark result with full text used for a wiki number."
  },
  "trials": [
    {
      "nct": "NCT04337242",
      "http": 200,
      "error": null,
      "briefTitle": "Blended Care Versus Face-to-Face Therapy for Depression",
      "overallStatus": "ACTIVE_NOT_RECRUITING",
      "lastUpdateSubmitDate": "2024-12-04",
      "lastUpdatePostDate": "2024-12-05",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 504,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT04959253",
      "http": 200,
      "error": null,
      "briefTitle": "Psilocybin in Depression Resistant to Standard Treatments",
      "overallStatus": "COMPLETED",
      "lastUpdateSubmitDate": "2026-08-25",
      "lastUpdatePostDate": "2026-08-28",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE2"
      ],
      "enrollment": 60,
      "enrollmentType": "ACTUAL"
    },
    {
      "nct": "NCT05415397",
      "http": 200,
      "error": null,
      "briefTitle": "Treating Immuno-metabolic Depression With Anti-inflammatory Drugs",
      "overallStatus": "COMPLETED",
      "lastUpdateSubmitDate": "2026-09-15",
      "lastUpdatePostDate": "2026-09-21",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE3"
      ],
      "enrollment": 94,
      "enrollmentType": "ACTUAL"
    },
    {
      "nct": "NCT05437588",
      "http": 200,
      "error": null,
      "briefTitle": "Neural-Derived Plasma Exosomal MicroRNAs As Promising Novel Biomarkers for Suicidality and Treatment Outcome in Adolescents",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2026-07-10",
      "lastUpdatePostDate": "2026-07-13",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 240,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT05616559",
      "http": 200,
      "error": null,
      "briefTitle": "Precision Medicine in the Depression Treatment",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2024-10-03",
      "lastUpdatePostDate": "2024-10-08",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": null,
      "enrollment": 800,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT05773755",
      "http": 200,
      "error": null,
      "briefTitle": "DBS for TRD With the Medtronic Percept PC",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2026-09-17",
      "lastUpdatePostDate": "2026-09-22",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 20,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT05786066",
      "http": 200,
      "error": null,
      "briefTitle": "The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2026-05-05",
      "lastUpdatePostDate": "2026-05-06",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE2"
      ],
      "enrollment": 30,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06110897",
      "http": 200,
      "error": null,
      "briefTitle": "RESISTance Exercise for Depression Trial",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2026-04-30",
      "lastUpdatePostDate": "2026-05-05",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 200,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06136546",
      "http": 200,
      "error": null,
      "briefTitle": "Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2025-05-06",
      "lastUpdatePostDate": "2025-05-07",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE2"
      ],
      "enrollment": 100,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06213324",
      "http": 200,
      "error": null,
      "briefTitle": "Neural Circuit Effects of Ketamine in Depression",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2025-06-30",
      "lastUpdatePostDate": "2025-07-03",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE4"
      ],
      "enrollment": 120,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06236880",
      "http": 200,
      "error": null,
      "briefTitle": "A Phase 2a Study to Evaluate the Safety and Tolerability of GM-2505 in Patients With MDD",
      "overallStatus": "COMPLETED",
      "lastUpdateSubmitDate": "2026-10-14",
      "lastUpdatePostDate": "2026-10-19",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE2"
      ],
      "enrollment": 126,
      "enrollmentType": "ACTUAL"
    },
    {
      "nct": "NCT06363981",
      "http": 200,
      "error": null,
      "briefTitle": "Multisite rTMS for Mood, Cognitive Impairment and Other Symptoms of Depression",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2024-10-09",
      "lastUpdatePostDate": "2024-10-15",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 90,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06392867",
      "http": 200,
      "error": null,
      "briefTitle": "Intermittent Theta-burst Stimulation for Major Depression: an Intensity-response Study",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2025-03-11",
      "lastUpdatePostDate": "2025-03-14",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 246,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06507787",
      "http": 200,
      "error": null,
      "briefTitle": "Evaluation of the Impact of the EDIT-B® Blood Test on the Health Status of Patients Presenting a Major Depressive Episode. Clinical Utility and Medico-Economic Aspects",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2025-02-14",
      "lastUpdatePostDate": "2025-02-18",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 450,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06511908",
      "http": 200,
      "error": null,
      "briefTitle": "Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2026-10-02",
      "lastUpdatePostDate": "2026-10-05",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE2"
      ],
      "enrollment": 50,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06547489",
      "http": 200,
      "error": null,
      "briefTitle": "Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2026-07-30",
      "lastUpdatePostDate": "2026-08-03",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE2"
      ],
      "enrollment": 164,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06626152",
      "http": 200,
      "error": null,
      "briefTitle": "Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trial",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2024-10-01",
      "lastUpdatePostDate": "2024-10-03",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE2"
      ],
      "enrollment": 50,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06732089",
      "http": 200,
      "error": null,
      "briefTitle": "Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2024-12-09",
      "lastUpdatePostDate": "2024-12-13",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": null,
      "enrollment": 200,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06793397",
      "http": 200,
      "error": null,
      "briefTitle": "A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2026-10-15",
      "lastUpdatePostDate": "2026-10-16",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE3"
      ],
      "enrollment": 330,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT06801925",
      "http": 200,
      "error": null,
      "briefTitle": "Evaluating the Effectiveness and Acceptability of a GPT-4o and RAG-Based Voice Chatbot for Depression Screening Using PHQ-9",
      "overallStatus": "ENROLLING_BY_INVITATION",
      "lastUpdateSubmitDate": "2025-01-24",
      "lastUpdatePostDate": "2025-01-30",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": null,
      "enrollment": 100,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT07042217",
      "http": 200,
      "error": null,
      "briefTitle": "Transcranial Direct Current Stimulation for Depression",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2026-10-13",
      "lastUpdatePostDate": "2026-10-19",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 25,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT07043738",
      "http": 200,
      "error": null,
      "briefTitle": "Imaging- vs. Scalp-Targeted Accelerated TMS for Depression: The Number Needed to Scan Trial",
      "overallStatus": "NOT_YET_RECRUITING",
      "lastUpdateSubmitDate": "2026-09-15",
      "lastUpdatePostDate": "2026-09-18",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 160,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT07139106",
      "http": 200,
      "error": null,
      "briefTitle": "Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts",
      "overallStatus": "NOT_YET_RECRUITING",
      "lastUpdateSubmitDate": "2026-07-30",
      "lastUpdatePostDate": "2026-08-03",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE4"
      ],
      "enrollment": 12,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT07226661",
      "http": 200,
      "error": null,
      "briefTitle": "Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder",
      "overallStatus": "RECRUITING",
      "lastUpdateSubmitDate": "2026-03-19",
      "lastUpdatePostDate": "2026-03-24",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE2"
      ],
      "enrollment": 230,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT07282366",
      "http": 200,
      "error": null,
      "briefTitle": "Video Intervention to Reduce Depression-related Stigma Among Adolescents",
      "overallStatus": "NOT_YET_RECRUITING",
      "lastUpdateSubmitDate": "2025-12-01",
      "lastUpdatePostDate": "2025-12-15",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 500,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT07373535",
      "http": 200,
      "error": null,
      "briefTitle": "Understanding Music and Mindfulness Preferences in Psilocybin-Assisted Psychotherapy",
      "overallStatus": "NOT_YET_RECRUITING",
      "lastUpdateSubmitDate": "2026-04-21",
      "lastUpdatePostDate": "2026-04-22",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "PHASE2"
      ],
      "enrollment": 16,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT07528157",
      "http": 200,
      "error": null,
      "briefTitle": "Early Brainwave Biomarkers for Personalized Neuromodulation in Treatment-resistant Depression",
      "overallStatus": "NOT_YET_RECRUITING",
      "lastUpdateSubmitDate": "2026-04-07",
      "lastUpdatePostDate": "2026-04-14",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 80,
      "enrollmentType": "ESTIMATED"
    },
    {
      "nct": "NCT07775586",
      "http": 200,
      "error": null,
      "briefTitle": "Home-Based Wearable rTMS Therapy for Moderate to Severe Depression",
      "overallStatus": "NOT_YET_RECRUITING",
      "lastUpdateSubmitDate": "2026-08-19",
      "lastUpdatePostDate": "2026-08-20",
      "resultsFirstPostDate": null,
      "hasResultsSection": false,
      "phases": [
        "NA"
      ],
      "enrollment": 124,
      "enrollmentType": "ESTIMATED"
    }
  ],
  "new_trials_queried": [
    {
      "nct": "NCT04953208",
      "overallStatus": "UNKNOWN",
      "lastUpdatePostDate": "2024-01-18",
      "hasResultsSection": false,
      "enrollment": 114,
      "briefTitle": "Remotely Non-invasive Brain Stimulation and Videogame to Alleviate Depression"
    },
    {
      "nct": "NCT06895863",
      "overallStatus": "RECRUITING",
      "lastUpdatePostDate": "2026-08-26",
      "hasResultsSection": false,
      "enrollment": 78,
      "briefTitle": "COpenhagen Magnetic Personalized Accelerated Brain Circuit Therapy for Treatment Resistant Depression"
    }
  ],
  "probes": [
    {
      "url": "https://www.cochranelibrary.com/",
      "status": 403,
      "final_url": "https://www.cochranelibrary.com/",
      "error": "HTTP Error 403: Forbidden",
      "bytes": 5475
    },
    {
      "url": "https://search.scielo.org/",
      "status": 403,
      "final_url": "https://search.scielo.org/",
      "error": "HTTP Error 403: Forbidden",
      "bytes": 2183
    },
    {
      "url": "https://trialsearch.who.int/",
      "status": 200,
      "final_url": "https://trialsearch.who.int/",
      "error": null,
      "bytes": 36375
    },
    {
      "url": "https://www.isrctn.com/api/query?q=depression",
      "status": 404,
      "final_url": "https://www.isrctn.com/api/query?q=depression",
      "error": "HTTP Error 404: Not Found",
      "bytes": 19302
    },
    {
      "url": "https://www.clinicaltrialsregister.eu/ctr-search/search?query=depression",
      "status": 200,
      "final_url": "https://www.clinicaltrialsregister.eu/ctr-search/search?query=depression",
      "error": null,
      "bytes": 78991
    },
    {
      "url": "https://www.clinicaltrialsregister.eu/ctr-search/trial/2018-003573-97/results",
      "status": 200,
      "final_url": "https://www.clinicaltrialsregister.eu/ctr-search/trial/2018-003573-97/results",
      "error": null,
      "bytes": 116646
    },
    {
      "url": "http://www.chictr.org.cn/searchproj.aspx",
      "status": 404,
      "final_url": "https://www.chictr.org.cn/searchproj.aspx",
      "error": "HTTP Error 404: ",
      "bytes": 104
    },
    {
      "url": "https://ctri.nic.in/Clinicaltrials/advancesearchmain.php",
      "status": 200,
      "final_url": "https://ctri.nic.in/Clinicaltrials/advancesearchmain.php",
      "error": null,
      "bytes": 25861
    },
    {
      "url": "https://lilacs.bvsalud.org/",
      "status": null,
      "final_url": null,
      "error": "URLError: <urlopen error timed out>",
      "bytes": 0
    }
  ],
  "guideline_and_org_pages": [
    {
      "url": "https://www.nice.org.uk/guidance/ng222",
      "status": 200,
      "final_url": "https://www.nice.org.uk/guidance/ng222",
      "bytes": 27284
    },
    {
      "url": "https://www.canmat.org/2025/04/29/major-depressive-disorder-guidelines-related-resources/",
      "status": 200,
      "final_url": "https://www.canmat.org/2025/04/29/major-depressive-disorder-guidelines-related-resources/",
      "bytes": 33817
    },
    {
      "url": "https://www.apa.org/depression-guideline",
      "status": 200,
      "final_url": "https://www.apa.org/depression-guideline",
      "bytes": 212
    },
    {
      "url": "https://www.psychiatry.org/psychiatrists/practice/clinical-practice-guidelines",
      "status": 200,
      "final_url": "https://www.psychiatry.org/psychiatrists/practice/clinical-practice-guidelines",
      "bytes": 238039
    },
    {
      "url": "https://www.healthquality.va.gov/guidelines/MH/mdd/",
      "status": 200,
      "final_url": "https://www.healthquality.va.gov/guidelines/MH/mdd/",
      "bytes": 75944
    },
    {
      "url": "https://www.who.int/news-room/fact-sheets/detail/depression",
      "status": 200,
      "final_url": "https://www.who.int/news-room/fact-sheets/detail/depression",
      "bytes": 113513
    },
    {
      "url": "https://www.mind.org.uk/",
      "status": 200,
      "final_url": "https://www.mind.org.uk/",
      "bytes": 166911
    },
    {
      "url": "https://mhanational.org/",
      "status": 200,
      "final_url": "https://mhanational.org/",
      "bytes": 143874
    },
    {
      "url": "https://www.dbsalliance.org/",
      "status": 200,
      "final_url": "https://www.dbsalliance.org/",
      "bytes": 156282
    },
    {
      "url": "https://www.beyondblue.org.au/",
      "status": 200,
      "final_url": "https://www.beyondblue.org.au/",
      "bytes": 347539
    },
    {
      "url": "https://www.sadag.org/",
      "status": 200,
      "final_url": "https://www.sadag.org/",
      "bytes": 63403
    }
  ],
  "followup_fulltext_still_unavailable": {
    "41500513": {
      "http": 200,
      "error": null,
      "title": "Exercise for depression.",
      "doi": "10.1002/14651858.cd004366.pub7",
      "isOpenAccess": "N",
      "inEPMC": "N",
      "inPMC": "N",
      "pmcid": null,
      "pubType": null,
      "fullTextUrls": [
        {
          "availability": "Subscription required",
          "documentStyle": "doi",
          "site": "DOI"
        }
      ]
    },
    "42581396": {
      "http": 200,
      "error": null,
      "title": "Individualized Connectivity-Guided Versus Conventional Targeting of Accelerated Theta-Burst Stimulation in Depression: A Randomized, Double-Blind, Parallel-Design Trial.",
      "doi": "10.1176/appi.ajp.20251084",
      "isOpenAccess": "N",
      "inEPMC": "N",
      "inPMC": "N",
      "pmcid": null,
      "pubType": null,
      "fullTextUrls": [
        {
          "availability": "Subscription required",
          "documentStyle": "doi",
          "site": "DOI"
        }
      ]
    },
    "42778211": {
      "http": 200,
      "error": null,
      "title": "QTc changes and early major adverse cardiovascular events associated with antidepressant treatment for major depressive disorder in adults: individual participant data network meta-regression of double blind randomised trials.",
      "doi": "10.1136/bmj-2026-100600",
      "isOpenAccess": "N",
      "inEPMC": "N",
      "inPMC": "N",
      "pmcid": null,
      "pubType": null,
      "fullTextUrls": [
        {
          "availability": "Subscription required",
          "documentStyle": "doi",
          "site": "DOI"
        }
      ]
    },
    "42814111": {
      "http": 200,
      "error": null,
      "title": "The discontinuation-emergent signs and symptoms (DESS) scale: reliable measurement-but perhaps not of antidepressant withdrawal.",
      "doi": "10.1007/s00406-026-02393-w",
      "isOpenAccess": "N",
      "inEPMC": "N",
      "inPMC": "N",
      "pmcid": null,
      "pubType": null,
      "fullTextUrls": [
        {
          "availability": "Subscription required",
          "documentStyle": "doi",
          "site": "DOI"
        }
      ]
    }
  },
  "openalex_retracted_in_window": {
    "http": 200,
    "count": 1,
    "results": [
      {
        "id": "https://openalex.org/W7204878960",
        "doi": "https://doi.org/10.1371/journal.pone.0357331",
        "display_name": "Retraction: Efficacy and safety of aripiprazole or bupropion augmentation and switching in patients with treatment-resistant depression or major depressive disorder: A systematic review and meta-analysis of randomized controlled trials",
        "publication_date": "2026-09-01",
        "type": "retraction",
        "is_retracted": true
      }
    ]
  },
  "doaj": {
    "http": 502,
    "error": "HTTP Error 502: Bad Gateway",
    "note": "HTTP 502. Not a completed search."
  },
  "unpaywall": "skipped; LIFEBANK_CONTACT_EMAIL unset",
  "crossref_mailto": "omitted; no contact email used",
  "added_record_summaries": {
    "42895746": {
      "uid": "42895746",
      "title": "Home Transcranial Direct Current Stimulation With Gamified Cognitive Control Training for Depression: A Randomized Clinical Trial.",
      "source": "JAMA Netw Open",
      "pubdate": "2026 Oct 1",
      "epubdate": "2026 Oct 1",
      "sortpubdate": "2026/10/01 00:00",
      "authors": [
        "Dechantsreiter E",
        "Padberg F",
        "Benjamini Y",
        "Goerigk S",
        "Rubene-Kesele L",
        "Konosonoka L"
      ],
      "lastauthor": "Nahum M",
      "pubtype": [
        "Journal Article",
        "Randomized Controlled Trial",
        "Multicenter Study"
      ],
      "doi": "10.1001/jamanetworkopen.2026.39400",
      "pmc": "PMC13681204"
    },
    "42629468": {
      "uid": "42629468",
      "title": "Dysregulated adult hippocampal neurogenesis in major depressive disorder.",
      "source": "Nat Med",
      "pubdate": "2026 Oct",
      "epubdate": "2026 Aug 21",
      "sortpubdate": "2026/10/01 00:00",
      "authors": [
        "Peng MS",
        "Jiang J",
        "Polizzi L",
        "Shi T",
        "Ramkumar R",
        "Anosike VO"
      ],
      "lastauthor": "Dupont MB",
      "pubtype": [
        "Journal Article"
      ],
      "doi": "10.1038/s41591-026-04571-8",
      "pmc": "PMC13668758"
    },
    "42890690": {
      "uid": "42890690",
      "title": "Copenhagen Magnetic Personalized Accelerated Brain Circuit Therapy (CoMPACT) trial: study protocol for a randomized, double-blinded, sham-controlled, three-armed, parallel-group trial of transcranial magnetic stimulation for treatment-resistant depression.",
      "source": "Front Psychiatry",
      "pubdate": "2026",
      "epubdate": "2026 Oct 2",
      "sortpubdate": "2026/10/02 00:00",
      "authors": [
        "Faghani Jadidi A",
        "Ibrahim I",
        "Christiansen L",
        "Beck MM",
        "Labanauskas V",
        "Sigurdsson B"
      ],
      "lastauthor": "Videbech P",
      "pubtype": [
        "Journal Article"
      ],
      "doi": "10.3389/fpsyt.2026.1937455",
      "pmc": "PMC13673963"
    },
    "42880603": {
      "uid": "42880603",
      "title": "Transcranial alternating current stimulation for major depressive disorder: An updated systematic review and meta-analysis of randomized trials with GRADE assessment.",
      "source": "J Affect Disord",
      "pubdate": "2026 Oct 15",
      "epubdate": "2026 Oct 15",
      "sortpubdate": "2026/10/15 00:00",
      "authors": [
        "Nabil Y",
        "Moghib KA",
        "Tarek Z",
        "Helmy Z",
        "Hatem N",
        "Mansour AEA"
      ],
      "lastauthor": "Seyed EKA",
      "pubtype": [
        "Journal Article",
        "Review"
      ],
      "doi": "10.1016/j.jad.2026.122606",
      "pmc": null
    },
    "42880279": {
      "uid": "42880279",
      "title": "Safety and efficacy of high-current tTIS targeting left sgACC for major depressive disorder: A randomized, double-blind, sham-controlled trial.",
      "source": "Cell Rep Med",
      "pubdate": "2026 Oct 15",
      "epubdate": "2026 Oct 15",
      "sortpubdate": "2026/10/15 00:00",
      "authors": [
        "Wang M",
        "Wu W",
        "Zheng Q",
        "Zhou H",
        "Ren J",
        "Gou H"
      ],
      "lastauthor": "Zhang X",
      "pubtype": [
        "Journal Article"
      ],
      "doi": "10.1016/j.xcrm.2026.103112",
      "pmc": null
    }
  },
  "retraction_checks_for_added_records": {
    "42895746": {
      "pubmed_pubtypes": [
        "Journal Article",
        "Randomized Controlled Trial",
        "Multicenter Study"
      ],
      "crossref_updated_by": [],
      "doi": "10.1001/jamanetworkopen.2026.39400"
    },
    "42629468": {
      "pubmed_pubtypes": [
        "Journal Article"
      ],
      "crossref_updated_by": [],
      "doi": "10.1038/s41591-026-04571-8"
    },
    "42890690": {
      "pubmed_pubtypes": [
        "Journal Article"
      ],
      "crossref_updated_by": [],
      "doi": "10.3389/fpsyt.2026.1937455"
    },
    "42880603": {
      "pubmed_pubtypes": [
        "Journal Article",
        "Review"
      ],
      "crossref_updated_by": [],
      "doi": "10.1016/j.jad.2026.122606"
    },
    "42880279": {
      "pubmed_pubtypes": [
        "Journal Article"
      ],
      "crossref_updated_by": [],
      "doi": "10.1016/j.xcrm.2026.103112"
    },
    "42656927": {
      "pubmed_pubtypes_from_efetch": [
        "Journal Article",
        "Review",
        "Retracted Publication"
      ],
      "crossref_updated_by": [],
      "doi": "10.7759/cureus.113431",
      "disposition": "Not cited and not added. PubMed flags Retracted Publication. Crossref updated-by was empty. PMC full text title is prefixed Retraction."
    }
  },
  "not_searched": [
    "Cochrane Library and CENTRAL: cochranelibrary.com HTTP 403",
    "SciELO: search.scielo.org HTTP 403",
    "LILACS: lilacs.bvsalud.org connection failed (no HTTP status)",
    "WHO ICTRP: trialsearch.who.int HTTP 200 HTML shell; no result count retrieved",
    "ISRCTN query API: HTTP 404",
    "ChiCTR searchproj.aspx: HTTP 404; showproj for ChiCTR2400094971 returned gzip that did not decode to readable text",
    "CTRI: advancesearchmain.php HTTP 200 search-form page, not a result set",
    "DOAJ: HTTP 502",
    "Unpaywall: skipped"
  ],
  "eu_ctr": {
    "depression_search": "https://www.clinicaltrialsregister.eu/ctr-search/search?query=depression HTTP 200; page text reported 1,481 result(s) for depression. This is the legacy EU CTR, not a complete CTIS review.",
    "eudract_2018-003573-97": "Results page HTTP 200. Results version number v1 (current). This version publication date 26 Sep 2026. No newer version on the page."
  },
  "triage": {
    "added_to_wiki": [
      "42895746",
      "42629468",
      "42890690",
      "42880603"
    ],
    "bibliography_only": [
      "42880279"
    ],
    "retracted_not_added": [
      "42656927"
    ],
    "known_retraction_notice_not_added": "OpenAlex DOI 10.1371/journal.pone.0357331, the aripiprazole/bupropion retraction already logged on 2026-10-15",
    "cochrane_exercise_pmid_41500513": "Europe PMC still reports subscription required, inPMC N, inEPMC N. No numeric update.",
    "conference_abstracts_without_pmid_or_doi": "Not citable. Includes lumateperone phase-3 pooled-subgroup posters, an LSD-microdosing RCT abstract, and a GLP-1 adjunct abstract in Eur Psychiatry / Int J Neuropsychopharmacol supplements."
  }
}
