{
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  "retrieved_on": "2026-10-21",
  "author": "Codex",
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        "42696036",
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        "42661508",
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        "42555525",
        "42526050",
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        "42473615",
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        "42263860",
        "42225263",
        "42219090",
        "42176466",
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        "42015883",
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        "41995627",
        "41954970",
        "41877636",
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        "41468956",
        "41326201",
        "40639955",
        "40586351",
        "40148257"
      ],
      "warnings": null
    },
    {
      "topic": "epidemiology-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (epidemiology OR prevalence OR incidence OR burden OR registry OR \"natural history\"))",
      "date_type": "pdat",
      "count": 1,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"low back pain\"[All Fields]) AND (\"epidemiologies\"[All Fields] OR \"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"epidemiology\"[MeSH Terms] OR \"epidemiology s\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields]) OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR (\"registries\"[MeSH Terms] OR \"registries\"[All Fields] OR \"registry\"[All Fields] OR \"registry s\"[All Fields]) OR \"natural history\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
        "42680183"
      ],
      "warnings": null
    },
    {
      "topic": "anatomy-biomechanics",
      "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (biomechanics OR endplate OR nutrition OR loading)",
      "date_type": "pdat",
      "count": 71,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"biomechanical phenomena\"[MeSH Terms] OR (\"biomechanical\"[All Fields] AND \"phenomena\"[All Fields]) OR \"biomechanical phenomena\"[All Fields] OR \"biomechanic\"[All Fields] OR \"biomechanics\"[All Fields] OR \"biomechanical\"[All Fields] OR \"biomechanically\"[All Fields] OR (\"endplate\"[All Fields] OR \"endplates\"[All Fields]) OR (\"nutrition s\"[All Fields] OR \"nutritional status\"[MeSH Terms] OR (\"nutritional\"[All Fields] AND \"status\"[All Fields]) OR \"nutritional status\"[All Fields] OR \"nutrition\"[All Fields] OR \"nutritional sciences\"[MeSH Terms] OR (\"nutritional\"[All Fields] AND \"sciences\"[All Fields]) OR \"nutritional sciences\"[All Fields] OR \"nutritional\"[All Fields] OR \"nutritionals\"[All Fields] OR \"nutritions\"[All Fields] OR \"nutritive\"[All Fields]) OR (\"loaded\"[All Fields] OR \"loading\"[All Fields] OR \"loadings\"[All Fields] OR \"loads\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
        "42900385",
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        "42462661",
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        "42360113",
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        "42219090",
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        "42095050",
        "42015883",
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        "41558602",
        "41496306",
        "41329449",
        "40673597",
        "38717315"
      ],
      "warnings": null
    },
    {
      "topic": "anatomy-biomechanics-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (biomechanics OR endplate OR nutrition OR loading))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"biomechanical phenomena\"[MeSH Terms] OR (\"biomechanical\"[All Fields] AND \"phenomena\"[All Fields]) OR \"biomechanical phenomena\"[All Fields] OR \"biomechanic\"[All Fields] OR \"biomechanics\"[All Fields] OR \"biomechanical\"[All Fields] OR \"biomechanically\"[All Fields] OR (\"endplate\"[All Fields] OR \"endplates\"[All Fields]) OR (\"nutrition s\"[All Fields] OR \"nutritional status\"[MeSH Terms] OR (\"nutritional\"[All Fields] AND \"status\"[All Fields]) OR \"nutritional status\"[All Fields] OR \"nutrition\"[All Fields] OR \"nutritional sciences\"[MeSH Terms] OR (\"nutritional\"[All Fields] AND \"sciences\"[All Fields]) OR \"nutritional sciences\"[All Fields] OR \"nutritional\"[All Fields] OR \"nutritionals\"[All Fields] OR \"nutritions\"[All Fields] OR \"nutritive\"[All Fields]) OR (\"loaded\"[All Fields] OR \"loading\"[All Fields] OR \"loadings\"[All Fields] OR \"loads\"[All Fields]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "cell-biology",
      "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (senescence OR inflammation OR ferroptosis OR molecular OR \"single cell\" OR transcriptomics)",
      "date_type": "pdat",
      "count": 113,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"aging\"[MeSH Terms] OR \"aging\"[All Fields] OR \"senescence\"[All Fields] OR \"senesce\"[All Fields] OR \"senesced\"[All Fields] OR \"senescences\"[All Fields] OR \"senescent\"[All Fields] OR \"senescents\"[All Fields] OR \"senesces\"[All Fields] OR \"senescing\"[All Fields] OR (\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation s\"[All Fields]) OR (\"ferroptosis\"[MeSH Terms] OR \"ferroptosis\"[All Fields]) OR (\"molecular\"[All Fields] OR \"moleculars\"[All Fields]) OR \"single cell\"[All Fields] OR (\"gene expression profiling\"[MeSH Terms] OR (\"gene\"[All Fields] AND \"expression\"[All Fields] AND \"profiling\"[All Fields]) OR \"gene expression profiling\"[All Fields] OR \"transcriptomics\"[All Fields] OR \"transcriptom\"[All Fields] OR \"transcriptomal\"[All Fields] OR \"transcriptome\"[MeSH Terms] OR \"transcriptome\"[All Fields] OR \"transcriptomes\"[All Fields] OR \"transcriptomic\"[All Fields] OR \"transcriptomically\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
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        "42178083",
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        "41990698",
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        "41496306",
        "41468956",
        "41329449"
      ],
      "warnings": null
    },
    {
      "topic": "cell-biology-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (senescence OR inflammation OR ferroptosis OR molecular OR \"single cell\" OR transcriptomics))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"aging\"[MeSH Terms] OR \"aging\"[All Fields] OR \"senescence\"[All Fields] OR \"senesce\"[All Fields] OR \"senesced\"[All Fields] OR \"senescences\"[All Fields] OR \"senescent\"[All Fields] OR \"senescents\"[All Fields] OR \"senesces\"[All Fields] OR \"senescing\"[All Fields] OR (\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation s\"[All Fields]) OR (\"ferroptosis\"[MeSH Terms] OR \"ferroptosis\"[All Fields]) OR (\"molecular\"[All Fields] OR \"moleculars\"[All Fields]) OR \"single cell\"[All Fields] OR (\"gene expression profiling\"[MeSH Terms] OR (\"gene\"[All Fields] AND \"expression\"[All Fields] AND \"profiling\"[All Fields]) OR \"gene expression profiling\"[All Fields] OR \"transcriptomics\"[All Fields] OR \"transcriptom\"[All Fields] OR \"transcriptomal\"[All Fields] OR \"transcriptome\"[MeSH Terms] OR \"transcriptome\"[All Fields] OR \"transcriptomes\"[All Fields] OR \"transcriptomic\"[All Fields] OR \"transcriptomically\"[All Fields]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "genetics-risk",
      "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (genetic OR GWAS OR smoking OR obesity OR occupational OR risk)",
      "date_type": "pdat",
      "count": 90,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"genetic\"[All Fields] OR \"genetical\"[All Fields] OR \"genetically\"[All Fields] OR \"genetics\"[MeSH Subheading] OR \"genetics\"[All Fields] OR \"genetics\"[MeSH Terms] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields]) OR (\"smoke\"[Supplementary Concept] OR \"smoke\"[All Fields] OR \"smoke\"[MeSH Terms] OR \"smoke s\"[All Fields] OR \"smoked\"[All Fields] OR \"smokes\"[All Fields] OR \"smoking\"[MeSH Terms] OR \"smoking\"[All Fields] OR \"smokings\"[All Fields] OR \"smoking s\"[All Fields]) OR (\"obeses\"[All Fields] OR \"obesity\"[MeSH Terms] OR \"obesity\"[All Fields] OR \"obese\"[All Fields] OR \"obesities\"[All Fields] OR \"obesity s\"[All Fields]) OR (\"occupant\"[All Fields] OR \"occupant s\"[All Fields] OR \"occupants\"[All Fields] OR \"occupational\"[All Fields] OR \"occupations\"[MeSH Terms] OR \"occupations\"[All Fields] OR \"occupation\"[All Fields]) OR (\"risk\"[MeSH Terms] OR \"risk\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
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        "42895774",
        "42892648",
        "42890622",
        "42890620",
        "42890091",
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        "42880403",
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        "42801296",
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        "42526050",
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        "42476215",
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        "42419172",
        "42413735",
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        "42372654",
        "42370393",
        "42360113",
        "42329412",
        "42324420",
        "42308800",
        "42225263",
        "42176466",
        "42169250",
        "42061462",
        "42017905",
        "41990698",
        "41985688",
        "41984178",
        "41954970",
        "41834130",
        "41779044",
        "41746347",
        "41636867",
        "41468958",
        "41468956",
        "41468578",
        "41329449",
        "40673597",
        "38717315"
      ],
      "warnings": null
    },
    {
      "topic": "genetics-risk-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (genetic OR GWAS OR smoking OR obesity OR occupational OR risk))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"genetic\"[All Fields] OR \"genetical\"[All Fields] OR \"genetically\"[All Fields] OR \"genetics\"[MeSH Subheading] OR \"genetics\"[All Fields] OR \"genetics\"[MeSH Terms] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields]) OR (\"smoke\"[Supplementary Concept] OR \"smoke\"[All Fields] OR \"smoke\"[MeSH Terms] OR \"smoke s\"[All Fields] OR \"smoked\"[All Fields] OR \"smokes\"[All Fields] OR \"smoking\"[MeSH Terms] OR \"smoking\"[All Fields] OR \"smokings\"[All Fields] OR \"smoking s\"[All Fields]) OR (\"obeses\"[All Fields] OR \"obesity\"[MeSH Terms] OR \"obesity\"[All Fields] OR \"obese\"[All Fields] OR \"obesities\"[All Fields] OR \"obesity s\"[All Fields]) OR (\"occupant\"[All Fields] OR \"occupant s\"[All Fields] OR \"occupants\"[All Fields] OR \"occupational\"[All Fields] OR \"occupations\"[MeSH Terms] OR \"occupations\"[All Fields] OR \"occupation\"[All Fields]) OR (\"risk\"[MeSH Terms] OR \"risk\"[All Fields]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "imaging-diagnosis",
      "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (MRI OR imaging OR Modic OR Pfirrmann OR discography OR diagnosis)",
      "date_type": "pdat",
      "count": 123,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"magnetic resonance imaging\"[MeSH Terms] OR (\"magnetic\"[All Fields] AND \"resonance\"[All Fields] AND \"imaging\"[All Fields]) OR \"magnetic resonance imaging\"[All Fields] OR \"mri\"[All Fields] OR (\"image s\"[All Fields] OR \"imaged\"[All Fields] OR \"imager\"[All Fields] OR \"imager s\"[All Fields] OR \"imagers\"[All Fields] OR \"images\"[All Fields] OR \"imaging\"[All Fields] OR \"imaging s\"[All Fields] OR \"imagings\"[All Fields] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[Supplementary Concept] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[All Fields] OR \"image\"[All Fields]) OR \"Modic\"[All Fields] OR (\"pfirrmann\"[All Fields] OR \"pfirrmann s\"[All Fields]) OR (\"discographies\"[All Fields] OR \"discography\"[All Fields]) OR (\"diagnosable\"[All Fields] OR \"diagnosi\"[All Fields] OR \"diagnosis\"[MeSH Terms] OR \"diagnosis\"[All Fields] OR \"diagnose\"[All Fields] OR \"diagnosed\"[All Fields] OR \"diagnoses\"[All Fields] OR \"diagnosing\"[All Fields] OR \"diagnosis\"[MeSH Subheading])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
        "42900386",
        "42900385",
        "42893279",
        "42890620",
        "42890091",
        "42889204",
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        "42733772",
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        "42481768",
        "42473702",
        "42462661",
        "42456529",
        "42428568",
        "42426267",
        "42419172",
        "42404489",
        "42388563",
        "42360113",
        "42324420",
        "42303789",
        "42234095",
        "42219090",
        "42178083",
        "42176466",
        "42169250",
        "42153663",
        "42105475",
        "42061462",
        "42035921",
        "42017905",
        "42015883",
        "41990698",
        "41985688",
        "41984178",
        "41862304",
        "41834130",
        "41823596",
        "41746347",
        "41559863",
        "41468956",
        "41468578",
        "41343348",
        "40673597",
        "38741513",
        "38717315"
      ],
      "warnings": null
    },
    {
      "topic": "imaging-diagnosis-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (MRI OR imaging OR Modic OR Pfirrmann OR discography OR diagnosis))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"magnetic resonance imaging\"[MeSH Terms] OR (\"magnetic\"[All Fields] AND \"resonance\"[All Fields] AND \"imaging\"[All Fields]) OR \"magnetic resonance imaging\"[All Fields] OR \"mri\"[All Fields] OR (\"image s\"[All Fields] OR \"imaged\"[All Fields] OR \"imager\"[All Fields] OR \"imager s\"[All Fields] OR \"imagers\"[All Fields] OR \"images\"[All Fields] OR \"imaging\"[All Fields] OR \"imaging s\"[All Fields] OR \"imagings\"[All Fields] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[Supplementary Concept] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[All Fields] OR \"image\"[All Fields]) OR \"Modic\"[All Fields] OR (\"pfirrmann\"[All Fields] OR \"pfirrmann s\"[All Fields]) OR (\"discographies\"[All Fields] OR \"discography\"[All Fields]) OR (\"diagnosable\"[All Fields] OR \"diagnosi\"[All Fields] OR \"diagnosis\"[MeSH Terms] OR \"diagnosis\"[All Fields] OR \"diagnose\"[All Fields] OR \"diagnosed\"[All Fields] OR \"diagnoses\"[All Fields] OR \"diagnosing\"[All Fields] OR \"diagnosis\"[MeSH Subheading]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "conservative",
      "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"chronic low back pain\") AND (exercise OR rehabilitation OR physiotherapy OR behavioral OR NSAID OR opioid OR nonoperative)",
      "date_type": "pdat",
      "count": 175,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"chronic low back pain\"[All Fields]) AND (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields] OR (\"rehabilitant\"[All Fields] OR \"rehabilitants\"[All Fields] OR \"rehabilitate\"[All Fields] OR \"rehabilitated\"[All Fields] OR \"rehabilitates\"[All Fields] OR \"rehabilitating\"[All Fields] OR \"rehabilitation\"[MeSH Terms] OR \"rehabilitation\"[All Fields] OR \"rehabilitations\"[All Fields] OR \"rehabilitative\"[All Fields] OR \"rehabilitation\"[MeSH Subheading] OR \"rehabilitation s\"[All Fields] OR \"rehabilitational\"[All Fields] OR \"rehabilitator\"[All Fields] OR \"rehabilitators\"[All Fields]) OR (\"physical therapy modalities\"[MeSH Terms] OR (\"physical\"[All Fields] AND \"therapy\"[All Fields] AND \"modalities\"[All Fields]) OR \"physical therapy modalities\"[All Fields] OR \"physiotherapies\"[All Fields] OR \"physiotherapy\"[All Fields]) OR (\"behavior s\"[All Fields] OR \"behaviorally\"[All Fields] OR \"behaviour\"[All Fields] OR \"behavior\"[MeSH Terms] OR \"behavior\"[All Fields] OR \"behavioural\"[All Fields] OR \"behavioral\"[All Fields] OR \"behaviourally\"[All Fields] OR \"behaviours\"[All Fields] OR \"behaviors\"[All Fields] OR \"pattern\"[All Fields] OR \"pattern s\"[All Fields] OR \"patternability\"[All Fields] OR \"patternable\"[All Fields] OR \"patterned\"[All Fields] OR \"patterning\"[All Fields] OR \"patternings\"[All Fields] OR \"patterns\"[All Fields]) OR (\"anti inflammatory agents non steroidal\"[Pharmacological Action] OR \"anti inflammatory agents non steroidal\"[Supplementary Concept] OR \"anti inflammatory agents non steroidal\"[All Fields] OR \"nsaid\"[All Fields] OR \"anti inflammatory agents, non steroidal\"[MeSH Terms] OR (\"anti inflammatory\"[All Fields] AND \"agents\"[All Fields] AND \"non steroidal\"[All Fields]) OR \"non-steroidal anti-inflammatory agents\"[All Fields] OR \"nsaids\"[All Fields] OR \"nsaid s\"[All Fields]) OR (\"analgesics opioid\"[Pharmacological Action] OR \"analgesics opioid\"[Supplementary Concept] OR \"analgesics opioid\"[All Fields] OR \"opioid\"[All Fields] OR \"analgesics, opioid\"[MeSH Terms] OR (\"analgesics\"[All Fields] AND \"opioid\"[All Fields]) OR \"opioid analgesics\"[All Fields] OR \"opioids\"[All Fields] OR \"opioid s\"[All Fields]) OR (\"nonop\"[All Fields] OR \"nonoperative\"[All Fields] OR \"nonoperatively\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
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        "42900385",
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        "42751572",
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        "42744636",
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        "42730496",
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        "42706474",
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        "42676088",
        "42676082",
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        "42665013",
        "42664123",
        "42663629",
        "42661508",
        "42615503",
        "42603980",
        "42600329",
        "42586858",
        "42581237",
        "42580901",
        "42551333",
        "42570301",
        "42569384",
        "42564747",
        "42564703",
        "42560474",
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        "42015883",
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      ],
      "warnings": null
    },
    {
      "topic": "conservative-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"chronic low back pain\") AND (exercise OR rehabilitation OR physiotherapy OR behavioral OR NSAID OR opioid OR nonoperative))",
      "date_type": "pdat",
      "count": 1,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"chronic low back pain\"[All Fields]) AND (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields] OR (\"rehabilitant\"[All Fields] OR \"rehabilitants\"[All Fields] OR \"rehabilitate\"[All Fields] OR \"rehabilitated\"[All Fields] OR \"rehabilitates\"[All Fields] OR \"rehabilitating\"[All Fields] OR \"rehabilitation\"[MeSH Terms] OR \"rehabilitation\"[All Fields] OR \"rehabilitations\"[All Fields] OR \"rehabilitative\"[All Fields] OR \"rehabilitation\"[MeSH Subheading] OR \"rehabilitation s\"[All Fields] OR \"rehabilitational\"[All Fields] OR \"rehabilitator\"[All Fields] OR \"rehabilitators\"[All Fields]) OR (\"physical therapy modalities\"[MeSH Terms] OR (\"physical\"[All Fields] AND \"therapy\"[All Fields] AND \"modalities\"[All Fields]) OR \"physical therapy modalities\"[All Fields] OR \"physiotherapies\"[All Fields] OR \"physiotherapy\"[All Fields]) OR (\"behavior s\"[All Fields] OR \"behaviorally\"[All Fields] OR \"behaviour\"[All Fields] OR \"behavior\"[MeSH Terms] OR \"behavior\"[All Fields] OR \"behavioural\"[All Fields] OR \"behavioral\"[All Fields] OR \"behaviourally\"[All Fields] OR \"behaviours\"[All Fields] OR \"behaviors\"[All Fields] OR \"pattern\"[All Fields] OR \"pattern s\"[All Fields] OR \"patternability\"[All Fields] OR \"patternable\"[All Fields] OR \"patterned\"[All Fields] OR \"patterning\"[All Fields] OR \"patternings\"[All Fields] OR \"patterns\"[All Fields]) OR (\"anti inflammatory agents non steroidal\"[Pharmacological Action] OR \"anti inflammatory agents non steroidal\"[Supplementary Concept] OR \"anti inflammatory agents non steroidal\"[All Fields] OR \"nsaid\"[All Fields] OR \"anti inflammatory agents, non steroidal\"[MeSH Terms] OR (\"anti inflammatory\"[All Fields] AND \"agents\"[All Fields] AND \"non steroidal\"[All Fields]) OR \"non-steroidal anti-inflammatory agents\"[All Fields] OR \"nsaids\"[All Fields] OR \"nsaid s\"[All Fields]) OR (\"analgesics opioid\"[Pharmacological Action] OR \"analgesics opioid\"[Supplementary Concept] OR \"analgesics opioid\"[All Fields] OR \"opioid\"[All Fields] OR \"analgesics, opioid\"[MeSH Terms] OR (\"analgesics\"[All Fields] AND \"opioid\"[All Fields]) OR \"opioid analgesics\"[All Fields] OR \"opioids\"[All Fields] OR \"opioid s\"[All Fields]) OR (\"nonop\"[All Fields] OR \"nonoperative\"[All Fields] OR \"nonoperatively\"[All Fields]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
        "42680183"
      ],
      "warnings": null
    },
    {
      "topic": "injections-ablation",
      "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (injection OR ablation OR basivertebral OR radiofrequency OR antibiotic)",
      "date_type": "pdat",
      "count": 27,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"inject\"[All Fields] OR \"injectability\"[All Fields] OR \"injectant\"[All Fields] OR \"injectants\"[All Fields] OR \"injectate\"[All Fields] OR \"injectates\"[All Fields] OR \"injected\"[All Fields] OR \"injectible\"[All Fields] OR \"injectibles\"[All Fields] OR \"injecting\"[All Fields] OR \"injections\"[MeSH Terms] OR \"injections\"[All Fields] OR \"injectable\"[All Fields] OR \"injectables\"[All Fields] OR \"injection\"[All Fields] OR \"injects\"[All Fields] OR (\"ablate\"[All Fields] OR \"ablated\"[All Fields] OR \"ablates\"[All Fields] OR \"ablating\"[All Fields] OR \"ablation\"[All Fields] OR \"ablational\"[All Fields] OR \"ablations\"[All Fields]) OR \"basivertebral\"[All Fields] OR (\"radiofrequencies\"[All Fields] OR \"radiofrequency\"[All Fields] OR \"radiofrequent\"[All Fields]) OR (\"anti bacterial agents\"[Pharmacological Action] OR \"anti bacterial agents\"[Supplementary Concept] OR \"anti bacterial agents\"[All Fields] OR \"antibiotic\"[All Fields] OR \"anti bacterial agents\"[MeSH Terms] OR (\"anti bacterial\"[All Fields] AND \"agents\"[All Fields]) OR \"antibiotics\"[All Fields] OR \"antibiotic s\"[All Fields] OR \"antibiotical\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
        "42887554",
        "42884176",
        "42874093",
        "42862440",
        "42853189",
        "42816544",
        "42806201",
        "42804305",
        "42777683",
        "42777337",
        "42771027",
        "42765343",
        "42754814",
        "42743208",
        "42729915",
        "42714274",
        "42690558",
        "42678490",
        "42564997",
        "42553289",
        "42500814",
        "42473702",
        "42473615",
        "42471059",
        "42388563",
        "42308800",
        "42015883"
      ],
      "warnings": null
    },
    {
      "topic": "injections-ablation-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (injection OR ablation OR basivertebral OR radiofrequency OR antibiotic))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"inject\"[All Fields] OR \"injectability\"[All Fields] OR \"injectant\"[All Fields] OR \"injectants\"[All Fields] OR \"injectate\"[All Fields] OR \"injectates\"[All Fields] OR \"injected\"[All Fields] OR \"injectible\"[All Fields] OR \"injectibles\"[All Fields] OR \"injecting\"[All Fields] OR \"injections\"[MeSH Terms] OR \"injections\"[All Fields] OR \"injectable\"[All Fields] OR \"injectables\"[All Fields] OR \"injection\"[All Fields] OR \"injects\"[All Fields] OR (\"ablate\"[All Fields] OR \"ablated\"[All Fields] OR \"ablates\"[All Fields] OR \"ablating\"[All Fields] OR \"ablation\"[All Fields] OR \"ablational\"[All Fields] OR \"ablations\"[All Fields]) OR \"basivertebral\"[All Fields] OR (\"radiofrequencies\"[All Fields] OR \"radiofrequency\"[All Fields] OR \"radiofrequent\"[All Fields]) OR (\"anti bacterial agents\"[Pharmacological Action] OR \"anti bacterial agents\"[Supplementary Concept] OR \"anti bacterial agents\"[All Fields] OR \"antibiotic\"[All Fields] OR \"anti bacterial agents\"[MeSH Terms] OR (\"anti bacterial\"[All Fields] AND \"agents\"[All Fields]) OR \"antibiotics\"[All Fields] OR \"antibiotic s\"[All Fields] OR \"antibiotical\"[All Fields]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "surgery",
      "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (fusion OR arthroplasty OR \"disc replacement\" OR reoperation)",
      "date_type": "pdat",
      "count": 44,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"fusion\"[All Fields] OR \"fusions\"[All Fields] OR (\"arthroplasty\"[MeSH Terms] OR \"arthroplasty\"[All Fields] OR \"arthroplasties\"[All Fields]) OR \"disc replacement\"[All Fields] OR (\"reoperate\"[All Fields] OR \"reoperated\"[All Fields] OR \"reoperating\"[All Fields] OR \"reoperation\"[MeSH Terms] OR \"reoperation\"[All Fields] OR \"reoperations\"[All Fields] OR \"reoperative\"[All Fields] OR \"second look surgery\"[MeSH Terms] OR (\"second look\"[All Fields] AND \"surgery\"[All Fields]) OR \"second look surgery\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
        "42881872",
        "42876555",
        "42875190",
        "42871559",
        "42855864",
        "42855423",
        "42854257",
        "42854246",
        "42853900",
        "42848213",
        "42824183",
        "42798646",
        "42798423",
        "42766026",
        "42752976",
        "42736121",
        "42727104",
        "42700672",
        "42690558",
        "42690540",
        "42683537",
        "42670602",
        "42665013",
        "42595025",
        "42535180",
        "42526050",
        "42503501",
        "42481768",
        "42456529",
        "42426267",
        "42419172",
        "42324420",
        "42235689",
        "42176466",
        "42017905",
        "41985688",
        "41984178",
        "41954970",
        "41834130",
        "41779044",
        "41636867",
        "41468578",
        "40673597",
        "38717315"
      ],
      "warnings": null
    },
    {
      "topic": "surgery-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (fusion OR arthroplasty OR \"disc replacement\" OR reoperation))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"fusion\"[All Fields] OR \"fusions\"[All Fields] OR (\"arthroplasty\"[MeSH Terms] OR \"arthroplasty\"[All Fields] OR \"arthroplasties\"[All Fields]) OR \"disc replacement\"[All Fields] OR (\"reoperate\"[All Fields] OR \"reoperated\"[All Fields] OR \"reoperating\"[All Fields] OR \"reoperation\"[MeSH Terms] OR \"reoperation\"[All Fields] OR \"reoperations\"[All Fields] OR \"reoperative\"[All Fields] OR \"second look surgery\"[MeSH Terms] OR (\"second look\"[All Fields] AND \"surgery\"[All Fields]) OR \"second look surgery\"[All Fields]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "regeneration",
      "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (cell OR regenerative OR biologic OR hydrogel OR platelet OR gene OR growth-factor)",
      "date_type": "pdat",
      "count": 140,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"cells\"[MeSH Terms] OR \"cells\"[All Fields] OR \"cell\"[All Fields] OR \"regenerative\"[All Fields] OR (\"biological products\"[Supplementary Concept] OR \"biological products\"[All Fields] OR \"biologic\"[All Fields] OR \"biological products\"[MeSH Terms] OR (\"biological\"[All Fields] AND \"products\"[All Fields]) OR \"biological\"[All Fields] OR \"biology\"[MeSH Terms] OR \"biology\"[All Fields] OR \"biologicals\"[All Fields] OR \"biological factors\"[Supplementary Concept] OR \"biological factors\"[All Fields] OR \"biological factors\"[MeSH Terms] OR (\"biological\"[All Fields] AND \"factors\"[All Fields]) OR \"biologics\"[All Fields] OR \"biologically\"[All Fields]) OR (\"hydrogel s\"[All Fields] OR \"hydrogelating\"[All Fields] OR \"hydrogelation\"[All Fields] OR \"hydrogelations\"[All Fields] OR \"hydrogelator\"[All Fields] OR \"hydrogelators\"[All Fields] OR \"hydrogels\"[Supplementary Concept] OR \"hydrogels\"[All Fields] OR \"hydrogel\"[All Fields] OR \"hydrogels\"[MeSH Terms]) OR (\"blood platelets\"[MeSH Terms] OR (\"blood\"[All Fields] AND \"platelets\"[All Fields]) OR \"blood platelets\"[All Fields] OR \"platelet\"[All Fields] OR \"platelets\"[All Fields] OR \"platelet s\"[All Fields] OR \"plateletes\"[All Fields]) OR (\"genes\"[MeSH Terms] OR \"genes\"[All Fields] OR \"gene\"[All Fields]) OR (\"intercellular signaling peptides and proteins\"[Supplementary Concept] OR \"intercellular signaling peptides and proteins\"[All Fields] OR \"growth factor\"[All Fields] OR \"intercellular signaling peptides and proteins\"[MeSH Terms] OR (\"intercellular\"[All Fields] AND \"signaling\"[All Fields] AND \"peptides\"[All Fields] AND \"proteins\"[All Fields]) OR (\"growth\"[All Fields] AND \"factor\"[All Fields]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
        "42900386",
        "42897005",
        "42895774",
        "42892648",
        "42890622",
        "42890091",
        "42889204",
        "42887554",
        "42884619",
        "42884176",
        "42880403",
        "42877538",
        "42876555",
        "42875857",
        "42873876",
        "42864749",
        "42863602",
        "42862440",
        "42861622",
        "42857979",
        "42855835",
        "42853189",
        "42852874",
        "42846521",
        "42841972",
        "42840758",
        "42840662",
        "42835960",
        "42835223",
        "42831202",
        "42824268",
        "42823843",
        "42816544",
        "42813570",
        "42812897",
        "42812589",
        "42811977",
        "42807803",
        "42804305",
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        "42759153",
        "42757472",
        "42755658",
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        "42635937",
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        "41468958",
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    },
    {
      "topic": "regeneration-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (cell OR regenerative OR biologic OR hydrogel OR platelet OR gene OR growth-factor))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"cells\"[MeSH Terms] OR \"cells\"[All Fields] OR \"cell\"[All Fields] OR \"regenerative\"[All Fields] OR (\"biological products\"[Supplementary Concept] OR \"biological products\"[All Fields] OR \"biologic\"[All Fields] OR \"biological products\"[MeSH Terms] OR (\"biological\"[All Fields] AND \"products\"[All Fields]) OR \"biological\"[All Fields] OR \"biology\"[MeSH Terms] OR \"biology\"[All Fields] OR \"biologicals\"[All Fields] OR \"biological factors\"[Supplementary Concept] OR \"biological factors\"[All Fields] OR \"biological factors\"[MeSH Terms] OR (\"biological\"[All Fields] AND \"factors\"[All Fields]) OR \"biologics\"[All Fields] OR \"biologically\"[All Fields]) OR (\"hydrogel s\"[All Fields] OR \"hydrogelating\"[All Fields] OR \"hydrogelation\"[All Fields] OR \"hydrogelations\"[All Fields] OR \"hydrogelator\"[All Fields] OR \"hydrogelators\"[All Fields] OR \"hydrogels\"[Supplementary Concept] OR \"hydrogels\"[All Fields] OR \"hydrogel\"[All Fields] OR \"hydrogels\"[MeSH Terms]) OR (\"blood platelets\"[MeSH Terms] OR (\"blood\"[All Fields] AND \"platelets\"[All Fields]) OR \"blood platelets\"[All Fields] OR \"platelet\"[All Fields] OR \"platelets\"[All Fields] OR \"platelet s\"[All Fields] OR \"plateletes\"[All Fields]) OR (\"genes\"[MeSH Terms] OR \"genes\"[All Fields] OR \"gene\"[All Fields]) OR (\"intercellular signaling peptides and proteins\"[Supplementary Concept] OR \"intercellular signaling peptides and proteins\"[All Fields] OR \"growth factor\"[All Fields] OR \"intercellular signaling peptides and proteins\"[MeSH Terms] OR (\"intercellular\"[All Fields] AND \"signaling\"[All Fields] AND \"peptides\"[All Fields] AND \"proteins\"[All Fields]) OR (\"growth\"[All Fields] AND \"factor\"[All Fields])))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "outcomes",
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      "date_type": "pdat",
      "count": 99,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"outcome\"[All Fields] OR \"outcomes\"[All Fields] OR (\"disabilities\"[All Fields] OR \"disability\"[All Fields] OR \"disablement\"[All Fields] OR \"disablements\"[All Fields] OR \"disabling\"[All Fields] OR \"disablity\"[All Fields] OR \"persons with disabilities\"[MeSH Terms] OR (\"persons\"[All Fields] AND \"disabilities\"[All Fields]) OR \"persons with disabilities\"[All Fields] OR \"disabled\"[All Fields]) OR \"quality of life\"[All Fields] OR \"MCID\"[All Fields] OR \"return to work\"[All Fields]) AND 2026/08/28:2026/10/21[Date - Publication]",
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        "38741513",
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      "warnings": null
    },
    {
      "topic": "outcomes-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (outcome OR disability OR \"quality of life\" OR MCID OR \"return to work\"))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"outcome\"[All Fields] OR \"outcomes\"[All Fields] OR (\"disabilities\"[All Fields] OR \"disability\"[All Fields] OR \"disablement\"[All Fields] OR \"disablements\"[All Fields] OR \"disabling\"[All Fields] OR \"disablity\"[All Fields] OR \"persons with disabilities\"[MeSH Terms] OR (\"persons\"[All Fields] AND \"disabilities\"[All Fields]) OR \"persons with disabilities\"[All Fields] OR \"disabled\"[All Fields]) OR \"quality of life\"[All Fields] OR \"MCID\"[All Fields] OR \"return to work\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "guidelines",
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      "date_type": "pdat",
      "count": 63,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"low back pain\"[All Fields]) AND (\"guideline\"[Publication Type] OR \"guidelines as topic\"[MeSH Terms] OR \"guideline\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR (\"recommend\"[All Fields] OR \"recommendable\"[All Fields] OR \"recommendation\"[All Fields] OR \"recommendation s\"[All Fields] OR \"recommendations\"[All Fields] OR \"recommended\"[All Fields] OR \"recommending\"[All Fields] OR \"recommends\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
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      ],
      "warnings": null
    },
    {
      "topic": "guidelines-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (guideline OR consensus OR recommendation))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"low back pain\"[All Fields]) AND (\"guideline\"[Publication Type] OR \"guidelines as topic\"[MeSH Terms] OR \"guideline\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR (\"recommend\"[All Fields] OR \"recommendable\"[All Fields] OR \"recommendation\"[All Fields] OR \"recommendation s\"[All Fields] OR \"recommendations\"[All Fields] OR \"recommended\"[All Fields] OR \"recommending\"[All Fields] OR \"recommends\"[All Fields]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "biomarkers",
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      "date_type": "pdat",
      "count": 93,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"biomarker s\"[All Fields] OR \"biomarkers\"[Supplementary Concept] OR \"biomarkers\"[All Fields] OR \"biomarker\"[All Fields] OR \"biomarkers\"[MeSH Terms] OR (\"proteom\"[All Fields] OR \"proteome\"[Supplementary Concept] OR \"proteome\"[All Fields] OR \"proteome\"[MeSH Terms] OR \"proteomes\"[All Fields] OR \"proteomical\"[All Fields] OR \"proteomically\"[All Fields] OR \"proteomics\"[MeSH Terms] OR \"proteomics\"[All Fields] OR \"proteomic\"[All Fields]) OR (\"metabolome\"[MeSH Terms] OR \"metabolome\"[All Fields] OR \"metabolomes\"[All Fields] OR \"metabolomics\"[MeSH Terms] OR \"metabolomics\"[All Fields] OR \"metabolomic\"[All Fields]) OR (\"valid\"[All Fields] OR \"validate\"[All Fields] OR \"validated\"[All Fields] OR \"validates\"[All Fields] OR \"validating\"[All Fields] OR \"validation\"[All Fields] OR \"validational\"[All Fields] OR \"validations\"[All Fields] OR \"validator\"[All Fields] OR \"validators\"[All Fields] OR \"validities\"[All Fields] OR \"validity\"[All Fields]) OR (\"predict\"[All Fields] OR \"predictabilities\"[All Fields] OR \"predictability\"[All Fields] OR \"predictable\"[All Fields] OR \"predictably\"[All Fields] OR \"predicted\"[All Fields] OR \"predicting\"[All Fields] OR \"prediction\"[All Fields] OR \"predictions\"[All Fields] OR \"predictive\"[All Fields] OR \"predictively\"[All Fields] OR \"predictiveness\"[All Fields] OR \"predictives\"[All Fields] OR \"predictivities\"[All Fields] OR \"predictivity\"[All Fields] OR \"predicts\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
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        "42413735",
        "42404489",
        "42401268",
        "42372654",
        "42370393",
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        "42235689",
        "42219090",
        "42176466",
        "42095050",
        "42061462",
        "42049200",
        "42017905",
        "41990698",
        "41985688",
        "41984178",
        "41834130",
        "41468956",
        "41468578"
      ],
      "warnings": null
    },
    {
      "topic": "biomarkers-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (biomarker OR proteomics OR metabolomics OR validation OR prediction))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"biomarker s\"[All Fields] OR \"biomarkers\"[Supplementary Concept] OR \"biomarkers\"[All Fields] OR \"biomarker\"[All Fields] OR \"biomarkers\"[MeSH Terms] OR (\"proteom\"[All Fields] OR \"proteome\"[Supplementary Concept] OR \"proteome\"[All Fields] OR \"proteome\"[MeSH Terms] OR \"proteomes\"[All Fields] OR \"proteomical\"[All Fields] OR \"proteomically\"[All Fields] OR \"proteomics\"[MeSH Terms] OR \"proteomics\"[All Fields] OR \"proteomic\"[All Fields]) OR (\"metabolome\"[MeSH Terms] OR \"metabolome\"[All Fields] OR \"metabolomes\"[All Fields] OR \"metabolomics\"[MeSH Terms] OR \"metabolomics\"[All Fields] OR \"metabolomic\"[All Fields]) OR (\"valid\"[All Fields] OR \"validate\"[All Fields] OR \"validated\"[All Fields] OR \"validates\"[All Fields] OR \"validating\"[All Fields] OR \"validation\"[All Fields] OR \"validational\"[All Fields] OR \"validations\"[All Fields] OR \"validator\"[All Fields] OR \"validators\"[All Fields] OR \"validities\"[All Fields] OR \"validity\"[All Fields]) OR (\"predict\"[All Fields] OR \"predictabilities\"[All Fields] OR \"predictability\"[All Fields] OR \"predictable\"[All Fields] OR \"predictably\"[All Fields] OR \"predicted\"[All Fields] OR \"predicting\"[All Fields] OR \"prediction\"[All Fields] OR \"predictions\"[All Fields] OR \"predictive\"[All Fields] OR \"predictively\"[All Fields] OR \"predictiveness\"[All Fields] OR \"predictives\"[All Fields] OR \"predictivities\"[All Fields] OR \"predictivity\"[All Fields] OR \"predicts\"[All Fields]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "trials",
      "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (randomized OR trial OR sham OR placebo)",
      "date_type": "pdat",
      "count": 43,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"random allocation\"[MeSH Terms] OR (\"random\"[All Fields] AND \"allocation\"[All Fields]) OR \"random allocation\"[All Fields] OR \"randomization\"[All Fields] OR \"randomized\"[All Fields] OR \"random\"[All Fields] OR \"randomisation\"[All Fields] OR \"randomisations\"[All Fields] OR \"randomise\"[All Fields] OR \"randomised\"[All Fields] OR \"randomising\"[All Fields] OR \"randomizations\"[All Fields] OR \"randomize\"[All Fields] OR \"randomizes\"[All Fields] OR \"randomizing\"[All Fields] OR \"randomness\"[All Fields] OR \"randoms\"[All Fields] OR (\"clinical trials as topic\"[MeSH Terms] OR (\"clinical\"[All Fields] AND \"trials\"[All Fields] AND \"topic\"[All Fields]) OR \"clinical trials as topic\"[All Fields] OR \"trial\"[All Fields] OR \"trial s\"[All Fields] OR \"trialed\"[All Fields] OR \"trialing\"[All Fields] OR \"trials\"[All Fields]) OR (\"salicylhydroxamic acid\"[Supplementary Concept] OR \"salicylhydroxamic acid\"[All Fields] OR \"sham\"[All Fields]) OR (\"placeboes\"[All Fields] OR \"placebos\"[Supplementary Concept] OR \"placebos\"[All Fields] OR \"placebo\"[All Fields] OR \"placebos\"[MeSH Terms])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
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        "42683537",
        "42476215",
        "42473615",
        "42404489",
        "42105475",
        "42015883"
      ],
      "warnings": null
    },
    {
      "topic": "trials-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (randomized OR trial OR sham OR placebo))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"random allocation\"[MeSH Terms] OR (\"random\"[All Fields] AND \"allocation\"[All Fields]) OR \"random allocation\"[All Fields] OR \"randomization\"[All Fields] OR \"randomized\"[All Fields] OR \"random\"[All Fields] OR \"randomisation\"[All Fields] OR \"randomisations\"[All Fields] OR \"randomise\"[All Fields] OR \"randomised\"[All Fields] OR \"randomising\"[All Fields] OR \"randomizations\"[All Fields] OR \"randomize\"[All Fields] OR \"randomizes\"[All Fields] OR \"randomizing\"[All Fields] OR \"randomness\"[All Fields] OR \"randoms\"[All Fields] OR (\"clinical trials as topic\"[MeSH Terms] OR (\"clinical\"[All Fields] AND \"trials\"[All Fields] AND \"topic\"[All Fields]) OR \"clinical trials as topic\"[All Fields] OR \"trial\"[All Fields] OR \"trial s\"[All Fields] OR \"trialed\"[All Fields] OR \"trialing\"[All Fields] OR \"trials\"[All Fields]) OR (\"salicylhydroxamic acid\"[Supplementary Concept] OR \"salicylhydroxamic acid\"[All Fields] OR \"sham\"[All Fields]) OR (\"placeboes\"[All Fields] OR \"placebos\"[Supplementary Concept] OR \"placebos\"[All Fields] OR \"placebo\"[All Fields] OR \"placebos\"[MeSH Terms]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "patient-experience",
      "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (qualitative OR \"patient experience\" OR \"patient priorities\" OR stigma OR \"lived experience\")",
      "date_type": "pdat",
      "count": 21,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"low back pain\"[All Fields]) AND (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields] OR \"patient experience\"[All Fields] OR \"patient priorities\"[All Fields] OR (\"social stigma\"[MeSH Terms] OR (\"social\"[All Fields] AND \"stigma\"[All Fields]) OR \"social stigma\"[All Fields] OR \"stigma\"[All Fields] OR \"stigmas\"[All Fields] OR \"stigma s\"[All Fields]) OR \"lived experience\"[All Fields]) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
        "42900415",
        "42870522",
        "42849905",
        "42835637",
        "42821814",
        "42815600",
        "42804306",
        "42792325",
        "42777337",
        "42753813",
        "42752440",
        "42751726",
        "42729314",
        "42706474",
        "42687133",
        "42662422",
        "42633118",
        "42560474",
        "41956901",
        "41665984",
        "40455078"
      ],
      "warnings": null
    },
    {
      "topic": "patient-experience-cochrane",
      "query": "\"Cochrane Database Syst Rev\"[jour] AND (((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (qualitative OR \"patient experience\" OR \"patient priorities\" OR stigma OR \"lived experience\"))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"low back pain\"[All Fields]) AND (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields] OR \"patient experience\"[All Fields] OR \"patient priorities\"[All Fields] OR (\"social stigma\"[MeSH Terms] OR (\"social\"[All Fields] AND \"stigma\"[All Fields]) OR \"social stigma\"[All Fields] OR \"stigma\"[All Fields] OR \"stigmas\"[All Fields] OR \"stigma s\"[All Fields]) OR \"lived experience\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
      "topic": "safety",
      "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (\"red flags\" OR \"cauda equina\" OR infection OR malignancy OR \"adverse event\" OR safety)",
      "date_type": "pdat",
      "count": 92,
      "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"low back pain\"[All Fields]) AND (\"red flags\"[All Fields] OR \"cauda equina\"[All Fields] OR (\"infect\"[All Fields] OR \"infectability\"[All Fields] OR \"infectable\"[All Fields] OR \"infectant\"[All Fields] OR \"infectants\"[All Fields] OR \"infected\"[All Fields] OR \"infecteds\"[All Fields] OR \"infectibility\"[All Fields] OR \"infectible\"[All Fields] OR \"infecting\"[All Fields] OR \"infection s\"[All Fields] OR \"infections\"[MeSH Terms] OR \"infections\"[All Fields] OR \"infection\"[All Fields] OR \"infective\"[All Fields] OR \"infectiveness\"[All Fields] OR \"infectives\"[All Fields] OR \"infectivities\"[All Fields] OR \"infects\"[All Fields] OR \"pathogenicity\"[MeSH Subheading] OR \"pathogenicity\"[All Fields] OR \"infectivity\"[All Fields]) OR (\"malign\"[All Fields] OR \"malignance\"[All Fields] OR \"malignances\"[All Fields] OR \"malignant\"[All Fields] OR \"malignants\"[All Fields] OR \"malignities\"[All Fields] OR \"malignity\"[All Fields] OR \"malignization\"[All Fields] OR \"malignized\"[All Fields] OR \"maligns\"[All Fields] OR \"neoplasms\"[MeSH Terms] OR \"neoplasms\"[All Fields] OR \"malignancies\"[All Fields] OR \"malignancy\"[All Fields]) OR \"adverse event\"[All Fields] OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
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        "41877636",
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        "41834130",
        "41612848",
        "41468578"
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      "warnings": null
    },
    {
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      "query": "\"Cochrane Database Syst Rev\"[jour] AND (((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (\"red flags\" OR \"cauda equina\" OR infection OR malignancy OR \"adverse event\" OR safety))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"low back pain\"[All Fields]) AND (\"red flags\"[All Fields] OR \"cauda equina\"[All Fields] OR (\"infect\"[All Fields] OR \"infectability\"[All Fields] OR \"infectable\"[All Fields] OR \"infectant\"[All Fields] OR \"infectants\"[All Fields] OR \"infected\"[All Fields] OR \"infecteds\"[All Fields] OR \"infectibility\"[All Fields] OR \"infectible\"[All Fields] OR \"infecting\"[All Fields] OR \"infection s\"[All Fields] OR \"infections\"[MeSH Terms] OR \"infections\"[All Fields] OR \"infection\"[All Fields] OR \"infective\"[All Fields] OR \"infectiveness\"[All Fields] OR \"infectives\"[All Fields] OR \"infectivities\"[All Fields] OR \"infects\"[All Fields] OR \"pathogenicity\"[MeSH Subheading] OR \"pathogenicity\"[All Fields] OR \"infectivity\"[All Fields]) OR (\"malign\"[All Fields] OR \"malignance\"[All Fields] OR \"malignances\"[All Fields] OR \"malignant\"[All Fields] OR \"malignants\"[All Fields] OR \"malignities\"[All Fields] OR \"malignity\"[All Fields] OR \"malignization\"[All Fields] OR \"malignized\"[All Fields] OR \"maligns\"[All Fields] OR \"neoplasms\"[MeSH Terms] OR \"neoplasms\"[All Fields] OR \"malignancies\"[All Fields] OR \"malignancy\"[All Fields]) OR \"adverse event\"[All Fields] OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields]))) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
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      "date_type": "pdat",
      "count": 18,
      "translation": "(\"chronic low back pain\"[Title/Abstract] OR \"low back pain\"[MeSH Major Topic]) AND (\"systematic review\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"network meta-analysis\"[Title/Abstract]) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
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        "42877061",
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        "42823645",
        "42804306",
        "42785965",
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        "42258429",
        "41869743",
        "41812784"
      ],
      "warnings": null
    },
    {
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      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"chronic low back pain\"[tiab] OR \"low back pain\"[majr]) AND (systematic review[pt] OR meta-analysis[pt] OR \"network meta-analysis\"[tiab]))",
      "date_type": "pdat",
      "count": 1,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"chronic low back pain\"[Title/Abstract] OR \"low back pain\"[MeSH Major Topic]) AND (\"systematic review\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"network meta-analysis\"[Title/Abstract])) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
        "42680183"
      ],
      "warnings": null
    },
    {
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      "date_type": "pdat",
      "count": 14,
      "translation": "\"chronic low back pain\"[Title/Abstract] AND \"randomized controlled trial\"[Publication Type] AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
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        "42284831",
        "42061275",
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      ],
      "warnings": null
    },
    {
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      "query": "\"Cochrane Database Syst Rev\"[jour] AND ((\"chronic low back pain\"[tiab]) AND (randomized controlled trial[pt]))",
      "date_type": "pdat",
      "count": 0,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"chronic low back pain\"[Title/Abstract] AND \"randomized controlled trial\"[Publication Type]) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [],
      "warnings": {
        "phrasesignored": [],
        "quotedphrasesnotfound": [],
        "outputmessages": [
          "No items found."
        ]
      }
    },
    {
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      "date_type": "pdat",
      "count": 1,
      "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"low back pain\"[All Fields] OR (\"sciatica\"[MeSH Terms] OR \"sciatica\"[All Fields] OR \"sciaticas\"[All Fields]) OR (\"lumbarised\"[All Fields] OR \"lumbarization\"[All Fields] OR \"lumbarized\"[All Fields] OR \"lumbars\"[All Fields] OR \"lumbosacral region\"[MeSH Terms] OR (\"lumbosacral\"[All Fields] AND \"region\"[All Fields]) OR \"lumbosacral region\"[All Fields] OR \"lumbar\"[All Fields]) OR \"intervertebral disc\"[All Fields]) AND 2026/08/28:2026/10/21[Date - Publication]",
      "ids": [
        "42680183"
      ]
    }
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    {
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    },
    {
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    },
    {
      "topic": "genetics-risk",
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    },
    {
      "topic": "imaging-diagnosis",
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      ]
    },
    {
      "topic": "conservative",
      "query": "(((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"chronic low back pain\") AND (exercise OR rehabilitation OR physiotherapy OR behavioral OR NSAID OR opioid OR nonoperative)) AND FIRST_PDATE:[2026-08-28 TO 2026-10-21]",
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    },
    {
      "topic": "injections-ablation",
      "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (injection OR ablation OR basivertebral OR radiofrequency OR antibiotic)) AND FIRST_PDATE:[2026-08-28 TO 2026-10-21]",
      "count": 123,
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      ]
    },
    {
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      "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (fusion OR arthroplasty OR \"disc replacement\" OR reoperation)) AND FIRST_PDATE:[2026-08-28 TO 2026-10-21]",
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      ]
    },
    {
      "topic": "regeneration",
      "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (cell OR regenerative OR biologic OR hydrogel OR platelet OR gene OR growth-factor)) AND FIRST_PDATE:[2026-08-28 TO 2026-10-21]",
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      ]
    },
    {
      "topic": "outcomes",
      "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (outcome OR disability OR \"quality of life\" OR MCID OR \"return to work\")) AND FIRST_PDATE:[2026-08-28 TO 2026-10-21]",
      "count": 228,
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    },
    {
      "topic": "guidelines",
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      ]
    },
    {
      "topic": "biomarkers",
      "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (biomarker OR proteomics OR metabolomics OR validation OR prediction)) AND FIRST_PDATE:[2026-08-28 TO 2026-10-21]",
      "count": 211,
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        "PMC:PMC13658900",
        "PMC:PMC13641234",
        "MED:42702834"
      ]
    },
    {
      "topic": "trials",
      "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (randomized OR trial OR sham OR placebo)) AND FIRST_PDATE:[2026-08-28 TO 2026-10-21]",
      "count": 136,
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      ]
    },
    {
      "topic": "patient-experience",
      "query": "(((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (qualitative OR \"patient experience\" OR \"patient priorities\" OR stigma OR \"lived experience\")) AND FIRST_PDATE:[2026-08-28 TO 2026-10-21]",
      "count": 176,
      "ids": [
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      ]
    },
    {
      "topic": "safety",
      "query": "(((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (\"red flags\" OR \"cauda equina\" OR infection OR malignancy OR \"adverse event\" OR safety)) AND FIRST_PDATE:[2026-08-28 TO 2026-10-21]",
      "count": 501,
      "ids": [
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      "title": "Perineal recurrence presenting as a cutaneous lesion after intersphincteric abdominoperineal resection for low rectal cancer: a case report with implications for surgical planning and postoperative surveillance.",
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      "inPMC": "Y"
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      "source": "MED",
      "id": "40639954",
      "title": "Objective, long-term mobility data in patients with chronic pain after lumbar spine surgery treated with spinal cord stimulation-a prospective, multicenter trial.",
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      "title": "Treatment of C-Section Scar with Light Touch as a Comparator to Myofascial Release in Patients with Chronic Low Back Pain Case Report",
      "doi": null,
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      "isOpenAccess": "Y",
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    {
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      "id": "42296329",
      "title": "Platelet-rich plasma versus corticosteroid injections for facet and sacroiliac joint pain: a systematic review and meta-analysis with trial sequential analysis.",
      "doi": "10.1093/pm/pnag072",
      "firstPublicationDate": "2026-10-01",
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    {
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      "title": "Effects of Hidden Conditioning and Positive Expectations on Pain Intensity Following Spinal Manipulative Therapy: A Three-Arm Randomized Controlled Trial.",
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    {
      "source": "MED",
      "id": "42696034",
      "title": "36-Month prospective multicenter randomized controlled trial comparing endoscopic facet denervation and cryoneurolysis for chronic lumbar facet joint pain.",
      "doi": "10.1007/s00586-026-10143-8",
      "firstPublicationDate": "2026-09-04",
      "isOpenAccess": "N",
      "inEPMC": "N",
      "inPMC": "N"
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    {
      "source": "MED",
      "id": "42812644",
      "title": "Platelet-Rich Plasma Injections for Refractory Sacroiliac Joint Pain: A Two-Patient Case Series.",
      "doi": "10.52965/001c.171213",
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      "isOpenAccess": "N",
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    {
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      "id": "42865518",
      "title": "Effectiveness of dynamic neuromuscular stabilization-based interventions for nonspecific low back pain: a systematic review and meta-analysis.",
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      "title": "Invasive Procedures for Most Musculoskeletal Conditions Are Not Better Than Placebo: A Systematic Review With Meta-Analysis.",
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      "isOpenAccess": "N",
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      "title": "Evidence of lower back pain, lumbosacral, sacroiliac joint, and pelvic asymmetries relevant to the posterior triangle effect: A systematic review protocol",
      "doi": "10.12688/f1000research.190297.1",
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    {
      "source": "PPR",
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      "title": "Building the Foundations: The Development of Attributes for a Discrete Choice Experiment on Spinal Manipulative Therapy for Low Back Pain in the Netherlands\u2014 The DECISION Project",
      "doi": "10.21203/rs.3.rs-10166272/v1",
      "firstPublicationDate": "2026-09-04",
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      "inEPMC": "N",
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    {
      "source": "MED",
      "id": "42843729",
      "title": "Health-related quality of life after ketamine or esketamine treatment for chronic pain: a review of randomized controlled trials.",
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      "title": "Pain Sensitivity, Pain Catastrophizing and Fear-Avoidance in Adult Runners: Injured vs. Uninjured Comparisons and Multivariable Associations.",
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    "no_new_statistics": true
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    "Preserve PubMed query translations. Supplementary broad/unmapped queries are marked superseded and not used for absence claims.",
    "Parse record IDs only from PubmedData/ArticleIdList; assert own PMID equals top-level MedlineCitation/PMID, excluding reference-list identifiers.",
    "EPMC syntax correction retained alongside original query; only corrected query is used for review coverage."
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    "SciELO/LILACS: HTTP 403 limitation; no regional absence claim.",
    "WHO ICTRP query returned HTTP 403; ISRCTN API queried instead. CTIS ABBA page returned a JS portal without usable study detail; European status not independently verified.",
    "Unpaywall skipped: LIFEBANK_CONTACT_EMAIL unset; no personal contact address used. Crossref queried without mailto.",
    "DOAJ and Embase/Scopus/Web of Science not searched.",
    "PRP meta-analysis and Skelly full guideline: publisher HTTP 403; Europe PMC reports no accessible full text. OpenAlex PRP citation graph queried."
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    "previously_added_without_snapshot": [
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      "NCT06827262"
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    "global_build": "Not run: task restricts edits to this condition; publishing handled separately."
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}