{ "condition": "degenerative-disc-disease", "retrieved_on": "2026-10-14", "author": "Claude (Opus 5.5)", "publication_window_inclusive": [ "2026-08-28", "2026-10-14" ], "window_note": "Each PubMed query was run twice (datetype=pdat and datetype=edat, mindate 2026/08/28, maxdate 2026/10/14, retmax 2000) and the ID sets unioned. IDs already listed in sweeps/2026-09-30.json were excluded from screening as previously screened. The base term was widened from the 2026-09-30 sweep by adding \"disc degeneration\" and \"Modic changes\". A Cochrane journal query, a systematic-review LBP query and an RCT LBP query were added.", "verification_level": "Live ESearch/ESummary/EFetch. Abstracts for retained records. Full text for Gao 2026 (Europe PMC PMC13522480) and Fillingim 2026 (publisher HTML). Madrazo-Ibarra 2026 full text HTTP 403 (Wiley); abstract-level only. Independent audit pending.", "pubmed_searches": [ { "topic": "overview", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\")", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "221", "edat_count": "154", "union_ids": [ "38717315", "38741513", "40673597", "41329449", "41343348", "41468578", "41468956", "41468958", "41496306", "41558602", "41559863", "41636867", "41665984", "41729208", "41732059", "41746347", "41779044", "41823596", "41834130", "41862304", "41954970", "41984178", "41985688", "41990698", "42006008", "42015883", "42017905", "42035921", "42049200", "42061462", "42095050", "42105475", "42153663", "42169250", "42176466", "42219090", "42225263", "42234095", "42235689", "42296781", "42303789", "42308800", "42322764", "42324420", "42329412", "42360113", "42370393", "42372654", "42388563", "42401268", "42404489", "42413735", "42419172", "42425027", "42426267", "42428568", "42435939", "42456529", "42462661", "42471059", "42473615", "42473702", "42476215", "42481768", "42492879", "42500814", "42501410", "42503501", "42517148", "42526050", "42526826", "42530800", "42535180", "42535225", "42535255", "42535354", "42553289", "42559161", "42562358", "42564703", "42564997", "42571481", "42571764", "42575212", "42595025", "42598138", "42600329", "42603980", "42635937", "42659810", "42660118", "42663054", "42665013", "42665979", "42666099", "42668501", "42670602", "42671335", "42675945", "42677233", "42677709", "42678490", "42678973", "42679087", "42679091", "42679426", "42683148", "42683424", "42683537", "42685933", "42688780", "42689520", "42690540", "42690558", "42691143", "42691205", "42693219", "42693467", "42694344", "42695042", "42695568", "42696036", "42697416", "42699943", "42703293", "42706237", "42707465", "42710426", "42711395", "42714274", "42717236", "42718399", "42719552", "42719629", "42720291", "42724059", "42726129", "42727104", "42728082", "42729493", "42729915", "42730662", "42731177", "42733314", "42733772", "42733874", "42736121", "42736733", "42738800", "42741378", "42743208", "42743872", "42744636", "42744959", "42749385", "42750036", "42752976", "42753964", "42754814", "42755658", "42757472", "42759153", "42761062", "42763742", "42765343", "42766026", "42766036", "42770026", "42771025", "42771027", "42774880", "42776360", "42776675", "42777337", "42777683", "42778683", "42778782", "42779216", "42781904", "42783798", "42786915", "42790727", "42792120", "42793736", "42794637", "42794657", "42798423", "42798628", "42798646", "42798950", "42799080", "42801296", "42801678", "42801693", "42802137", "42803180", "42804305", "42804313", "42806201", "42807803", "42811977", "42812589", "42812897", "42813570", "42815170", "42815615", "42816544", "42819576", "42822030", "42823843", "42824183", "42824268", "42829533", "42830963", "42831019", "42831202", "42835223", "42835960", "42836528", "42839758", "42840662", "42840758", "42841972", "42844679", "42846521", "42848213", "42849550", "42850345", "42852874", "42853189", "42853900", "42854246", "42854257", "42855423", "42855434", "42855835", "42855864", "42857979", "42861160", "42861622", "42862440", "42863602", "42864749" ], "not_screened_2026_09_30": [ "38717315", "40673597", "41329449", "41343348", "41468956", "41468958", "41558602", "41729208", "41746347", "41823596", "41834130", "41985688", "41990698", "42035921", "42105475", "42153663", "42169250", "42360113", "42413735", "42419172", "42425027", "42435939", "42456529", "42462661", "42476215", "42530800", "42535255", "42535354", "42553289", "42571481", "42571764", "42575212", "42595025", "42598138", "42603980", "42659810", "42663054", "42677233", "42677709", "42679087", "42679091", "42679426", "42683424", "42691143", "42693467", "42694344", "42696036", "42707465", "42711395", "42718399", "42719552", "42719629", "42724059", "42727104", "42729493", "42730662", "42736733", "42738800", "42741378", "42749385", "42750036", "42759153", "42763742", "42766026", "42778782", "42781904", "42786915", "42790727", "42798628", "42803180", "42804313", "42815170", "42815615", "42816544", "42819576", "42822030", "42823843", "42824183", "42824268", "42829533", "42830963", "42831019", "42831202", "42835223", "42835960", "42836528", "42839758", "42840662", "42840758", "42841972", "42844679", "42846521", "42848213", "42849550", "42850345", "42852874", "42853189", "42853900", "42854246", "42854257", "42855423", "42855434", "42855835", "42855864", "42857979", "42861160", "42861622", "42862440", "42863602", "42864749" ] }, { "topic": "epidemiology", "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (epidemiology OR prevalence OR incidence OR burden OR registry OR \"natural history\")", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"low back pain\"[All Fields]) AND (\"epidemiologies\"[All Fields] OR \"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"epidemiology\"[MeSH Terms] OR \"epidemiology s\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields]) OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR (\"registries\"[MeSH Terms] OR \"registries\"[All Fields] OR \"registry\"[All Fields] OR \"registry s\"[All Fields]) OR \"natural history\"[All Fields]) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "170", "edat_count": "136", "union_ids": [ "32491493", "40148257", "40586351", "40639955", "41326201", "41468956", "41559863", "41592680", "41732059", "41779044", "41834130", "41877636", "41954970", "41995627", "42006008", "42015883", "42061275", "42061764", "42083926", "42095615", "42108930", "42176466", "42219090", "42225263", "42263860", "42301237", "42303789", "42315405", "42320269", "42320822", "42324420", "42377890", "42385546", "42413324", "42419172", "42419416", "42419970", "42425027", "42427268", "42434718", "42456529", "42473615", "42481768", "42522050", "42526050", "42555525", "42561632", "42566849", "42570301", "42571275", "42575212", "42602955", "42661508", "42662446", "42663634", "42668501", "42670051", "42670404", "42670602", "42671763", "42676468", "42677216", "42678973", "42679904", "42680080", "42680183", "42687133", "42688083", "42688780", "42688837", "42691205", "42691719", "42693219", "42695042", "42696036", "42696314", "42697255", "42698475", "42698699", "42700878", "42706474", "42710331", "42712230", "42713377", "42713388", "42714274", "42714957", "42723300", "42723949", "42729952", "42732048", "42733314", "42733749", "42734834", "42736121", "42736943", "42736986", "42737010", "42739658", "42739707", "42739868", "42741512", "42743872", "42744233", "42744959", "42747017", "42747281", "42752440", "42752976", "42753813", "42754814", "42755474", "42755755", "42758004", "42758323", "42759032", "42762487", "42762713", "42765154", "42765774", "42766023", "42766026", "42766036", "42766617", "42767531", "42770026", "42771025", "42771047", "42771844", "42772118", "42773786", "42775848", "42777078", "42777337", "42778782", "42779894", "42781724", "42785648", "42785965", "42786905", "42787438", "42788574", "42793573", "42793736", "42794657", "42796083", "42798423", "42801130", "42804297", "42805513", "42814623", "42815217", "42818789", "42821151", "42821491", "42821881", "42823843", "42823924", "42826821", "42827149", "42827429", "42829583", "42831019", "42833965", "42834228", "42836528", "42836969", "42841972", "42842357", "42842811", "42844006", "42844679", "42847400", "42847479", "42849905", "42850344", "42850347", "42851896", "42852784", "42853055", "42853621", "42856590", "42857979", "42858093", "42861521", "42863602", "42865518" ], "not_screened_2026_09_30": [ "40639955", "41468956", "41592680", "41834130", "41995627", "42263860", "42315405", "42320269", "42320822", "42377890", "42419172", "42425027", "42427268", "42456529", "42555525", "42561632", "42566849", "42575212", "42602955", "42662446", "42670404", "42676468", "42677216", "42688083", "42696036", "42698475", "42713377", "42714957", "42723949", "42744233", "42747281", "42766026", "42772118", "42778782", "42787438", "42814623", "42815217", "42818789", "42821151", "42821491", "42821881", "42823843", "42823924", "42826821", "42827149", "42827429", "42829583", "42831019", "42833965", "42834228", "42836528", "42836969", "42841972", "42842357", "42842811", "42844006", "42844679", "42847400", "42847479", "42849905", "42850344", "42850347", "42851896", "42852784", "42853055", "42853621", "42856590", "42857979", "42858093", "42861521", "42863602", "42865518" ] }, { "topic": "anatomy-biomechanics", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (biomechanics OR endplate OR nutrition OR loading)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"biomechanical phenomena\"[MeSH Terms] OR (\"biomechanical\"[All Fields] AND \"phenomena\"[All Fields]) OR \"biomechanical phenomena\"[All Fields] OR \"biomechanic\"[All Fields] OR \"biomechanics\"[All Fields] OR \"biomechanical\"[All Fields] OR \"biomechanically\"[All Fields] OR (\"endplate\"[All Fields] OR \"endplates\"[All Fields]) OR (\"nutrition s\"[All Fields] OR \"nutritional status\"[MeSH Terms] OR (\"nutritional\"[All Fields] AND \"status\"[All Fields]) OR \"nutritional status\"[All Fields] OR \"nutrition\"[All Fields] OR \"nutritional sciences\"[MeSH Terms] OR (\"nutritional\"[All Fields] AND \"sciences\"[All Fields]) OR \"nutritional sciences\"[All Fields] OR \"nutritional\"[All Fields] OR \"nutritionals\"[All Fields] OR \"nutritions\"[All Fields] OR \"nutritive\"[All Fields]) OR (\"loaded\"[All Fields] OR \"loading\"[All Fields] OR \"loadings\"[All Fields] OR \"loads\"[All Fields])) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "64", "edat_count": "45", "union_ids": [ "38717315", "40673597", "41329449", "41496306", "41558602", "41834130", "42015883", "42095050", "42153663", "42219090", "42225263", "42303789", "42360113", "42413735", "42435939", "42462661", "42481768", "42492879", "42503501", "42526050", "42526826", "42535255", "42553289", "42559161", "42564703", "42595025", "42665013", "42668501", "42677233", "42678490", "42679087", "42679091", "42679426", "42691205", "42693219", "42694344", "42695042", "42695568", "42703293", "42711395", "42719552", "42728082", "42729493", "42733772", "42738800", "42744959", "42750036", "42753964", "42765343", "42766026", "42771027", "42777337", "42777683", "42779216", "42781904", "42783798", "42790727", "42798423", "42801678", "42807803", "42815170", "42824183", "42829533", "42831202", "42840662", "42840758", "42849550", "42850345", "42855434", "42855864", "42862440" ], "not_screened_2026_09_30": [ "38717315", "40673597", "41329449", "41558602", "41834130", "42153663", "42360113", "42413735", "42435939", "42462661", "42535255", "42553289", "42595025", "42677233", "42679087", "42679091", "42679426", "42694344", "42711395", "42719552", "42729493", "42738800", "42750036", "42766026", "42781904", "42790727", "42815170", "42824183", "42829533", "42831202", "42840662", "42840758", "42849550", "42850345", "42855434", "42855864", "42862440" ] }, { "topic": "cell-biology", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (senescence OR inflammation OR ferroptosis OR molecular OR \"single cell\" OR transcriptomics)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"aging\"[MeSH Terms] OR \"aging\"[All Fields] OR \"senescence\"[All Fields] OR \"senesce\"[All Fields] OR \"senesced\"[All Fields] OR \"senescences\"[All Fields] OR \"senescent\"[All Fields] OR \"senescents\"[All Fields] OR \"senesces\"[All Fields] OR \"senescing\"[All Fields] OR (\"inflammation\"[MeSH Terms] OR \"inflammation\"[All Fields] OR \"inflammations\"[All Fields] OR \"inflammation s\"[All Fields]) OR (\"ferroptosis\"[MeSH Terms] OR \"ferroptosis\"[All Fields]) OR (\"molecular\"[All Fields] OR \"moleculars\"[All Fields]) OR \"single cell\"[All Fields] OR (\"gene expression profiling\"[MeSH Terms] OR (\"gene\"[All Fields] AND \"expression\"[All Fields] AND \"profiling\"[All Fields]) OR \"gene expression profiling\"[All Fields] OR \"transcriptomics\"[All Fields] OR \"transcriptom\"[All Fields] OR \"transcriptomal\"[All Fields] OR \"transcriptome\"[MeSH Terms] OR \"transcriptome\"[All Fields] OR \"transcriptomes\"[All Fields] OR \"transcriptomic\"[All Fields] OR \"transcriptomically\"[All Fields])) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "96", "edat_count": "66", "union_ids": [ "41329449", "41468956", "41496306", "41558602", "41732059", "41990698", "42035921", "42049200", "42095050", "42105475", "42169250", "42296781", "42308800", "42322764", "42329412", "42370393", "42372654", "42401268", "42404489", "42413735", "42428568", "42435939", "42471059", "42476215", "42492879", "42500814", "42501410", "42517148", "42530800", "42535354", "42553289", "42559161", "42564703", "42571764", "42575212", "42595025", "42598138", "42603980", "42659810", "42660118", "42665979", "42666099", "42668501", "42671335", "42678490", "42679426", "42683148", "42685933", "42688780", "42689520", "42691205", "42694344", "42697416", "42703293", "42706237", "42707465", "42719629", "42720291", "42726129", "42728082", "42733772", "42733874", "42743872", "42744959", "42749385", "42750036", "42754814", "42755658", "42757472", "42759153", "42761062", "42763742", "42766036", "42771025", "42771027", "42774880", "42776360", "42777683", "42778683", "42794637", "42794657", "42801678", "42801693", "42803180", "42807803", "42811977", "42812589", "42815615", "42816544", "42823843", "42824268", "42829533", "42835223", "42835960", "42839758", "42840662", "42841972", "42846521", "42849550", "42855835", "42855864", "42857979", "42863602", "42864749" ], "not_screened_2026_09_30": [ "41329449", "41468956", "41558602", "41990698", "42035921", "42105475", "42169250", "42413735", "42435939", "42476215", "42530800", "42535354", "42553289", "42571764", "42575212", "42595025", "42598138", "42603980", "42659810", "42679426", "42694344", "42707465", "42719629", "42749385", "42750036", "42759153", "42763742", "42803180", "42815615", "42816544", "42823843", "42824268", "42829533", "42835223", "42835960", "42839758", "42840662", "42841972", "42846521", "42849550", "42855835", "42855864", "42857979", "42863602", "42864749" ] }, { "topic": "genetics-risk", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (genetic OR GWAS OR smoking OR obesity OR occupational OR risk)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"genetic\"[All Fields] OR \"genetical\"[All Fields] OR \"genetically\"[All Fields] OR \"genetics\"[MeSH Subheading] OR \"genetics\"[All Fields] OR \"genetics\"[MeSH Terms] OR (\"genome wide association study\"[MeSH Terms] OR (\"genome wide\"[All Fields] AND \"association\"[All Fields] AND \"study\"[All Fields]) OR \"genome wide association study\"[All Fields] OR \"gwas\"[All Fields]) OR (\"smoke\"[Supplementary Concept] OR \"smoke\"[All Fields] OR \"smoke\"[MeSH Terms] OR \"smoke s\"[All Fields] OR \"smoked\"[All Fields] OR \"smokes\"[All Fields] OR \"smoking\"[MeSH Terms] OR \"smoking\"[All Fields] OR \"smokings\"[All Fields] OR \"smoking s\"[All Fields]) OR (\"obeses\"[All Fields] OR \"obesity\"[MeSH Terms] OR \"obesity\"[All Fields] OR \"obese\"[All Fields] OR \"obesities\"[All Fields] OR \"obesity s\"[All Fields]) OR (\"occupant\"[All Fields] OR \"occupant s\"[All Fields] OR \"occupants\"[All Fields] OR \"occupational\"[All Fields] OR \"occupations\"[MeSH Terms] OR \"occupations\"[All Fields] OR \"occupation\"[All Fields]) OR (\"risk\"[MeSH Terms] OR \"risk\"[All Fields])) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "78", "edat_count": "47", "union_ids": [ "38717315", "40673597", "41329449", "41468578", "41468956", "41468958", "41636867", "41746347", "41779044", "41834130", "41954970", "41984178", "41985688", "41990698", "42017905", "42061462", "42169250", "42176466", "42225263", "42308800", "42324420", "42329412", "42360113", "42370393", "42372654", "42401268", "42413735", "42419172", "42426267", "42476215", "42481768", "42517148", "42526050", "42535255", "42559161", "42575212", "42660118", "42670602", "42671335", "42677233", "42683424", "42683537", "42685933", "42688780", "42689520", "42706237", "42717236", "42719629", "42727104", "42730662", "42736733", "42738800", "42741378", "42744636", "42744959", "42750036", "42752976", "42754814", "42766026", "42770026", "42771025", "42776360", "42777337", "42778782", "42783798", "42793736", "42799080", "42801296", "42803180", "42804305", "42811977", "42816544", "42823843", "42824183", "42831019", "42831202", "42840662", "42844679", "42850345", "42853900", "42854246", "42855835", "42863602" ], "not_screened_2026_09_30": [ "38717315", "40673597", "41329449", "41468956", "41468958", "41746347", "41834130", "41985688", "41990698", "42169250", "42360113", "42413735", "42419172", "42476215", "42535255", "42575212", "42677233", "42683424", "42719629", "42727104", "42730662", "42736733", "42738800", "42741378", "42750036", "42766026", "42778782", "42803180", "42816544", "42823843", "42824183", "42831019", "42831202", "42840662", "42844679", "42850345", "42853900", "42854246", "42855835", "42863602" ] }, { "topic": "imaging-diagnosis", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (MRI OR imaging OR Modic OR Pfirrmann OR discography OR diagnosis)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"magnetic resonance imaging\"[MeSH Terms] OR (\"magnetic\"[All Fields] AND \"resonance\"[All Fields] AND \"imaging\"[All Fields]) OR \"magnetic resonance imaging\"[All Fields] OR \"mri\"[All Fields] OR (\"image s\"[All Fields] OR \"imaged\"[All Fields] OR \"imager\"[All Fields] OR \"imager s\"[All Fields] OR \"imagers\"[All Fields] OR \"images\"[All Fields] OR \"imaging\"[All Fields] OR \"imaging s\"[All Fields] OR \"imagings\"[All Fields] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[Supplementary Concept] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[All Fields] OR \"image\"[All Fields]) OR \"Modic\"[All Fields] OR (\"pfirrmann\"[All Fields] OR \"pfirrmann s\"[All Fields]) OR (\"discographies\"[All Fields] OR \"discography\"[All Fields]) OR (\"diagnosable\"[All Fields] OR \"diagnosi\"[All Fields] OR \"diagnosis\"[MeSH Terms] OR \"diagnosis\"[All Fields] OR \"diagnose\"[All Fields] OR \"diagnosed\"[All Fields] OR \"diagnoses\"[All Fields] OR \"diagnosing\"[All Fields] OR \"diagnosis\"[MeSH Subheading])) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "104", "edat_count": "66", "union_ids": [ "38717315", "38741513", "40673597", "41343348", "41468578", "41468956", "41559863", "41746347", "41823596", "41834130", "41862304", "41984178", "41985688", "41990698", "42015883", "42017905", "42035921", "42061462", "42105475", "42153663", "42169250", "42176466", "42219090", "42234095", "42303789", "42324420", "42360113", "42388563", "42404489", "42419172", "42426267", "42428568", "42456529", "42462661", "42473702", "42481768", "42500814", "42501410", "42517148", "42526050", "42526826", "42530800", "42535225", "42535255", "42553289", "42562358", "42564703", "42564997", "42571481", "42600329", "42663054", "42665013", "42666099", "42675945", "42677709", "42678490", "42678973", "42679087", "42679091", "42679426", "42683424", "42691143", "42693219", "42693467", "42695042", "42696036", "42699943", "42710426", "42718399", "42720291", "42727104", "42728082", "42729915", "42730662", "42733314", "42733772", "42736121", "42736733", "42741378", "42744636", "42744959", "42750036", "42754814", "42755658", "42765343", "42766026", "42771025", "42777337", "42778782", "42779216", "42786915", "42792120", "42793736", "42798423", "42799080", "42801693", "42803180", "42804305", "42804313", "42806201", "42807803", "42815170", "42822030", "42823843", "42824183", "42829533", "42830963", "42831019", "42836528", "42839758", "42840758", "42844679", "42848213", "42850345", "42855434", "42863602" ], "not_screened_2026_09_30": [ "38717315", "40673597", "41343348", "41468956", "41746347", "41823596", "41834130", "41985688", "41990698", "42035921", "42105475", "42153663", "42169250", "42360113", "42419172", "42456529", "42462661", "42530800", "42535255", "42553289", "42571481", "42663054", "42677709", "42679087", "42679091", "42679426", "42683424", "42691143", "42693467", "42696036", "42718399", "42727104", "42730662", "42736733", "42741378", "42750036", "42766026", "42778782", "42786915", "42803180", "42804313", "42815170", "42822030", "42823843", "42824183", "42829533", "42830963", "42831019", "42836528", "42839758", "42840758", "42844679", "42848213", "42850345", "42855434", "42863602" ] }, { "topic": "conservative", "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"chronic low back pain\") AND (exercise OR rehabilitation OR physiotherapy OR behavioral OR NSAID OR opioid OR nonoperative)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"chronic low back pain\"[All Fields]) AND (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields] OR (\"rehabilitant\"[All Fields] OR \"rehabilitants\"[All Fields] OR \"rehabilitate\"[All Fields] OR \"rehabilitated\"[All Fields] OR \"rehabilitates\"[All Fields] OR \"rehabilitating\"[All Fields] OR \"rehabilitation\"[MeSH Terms] OR \"rehabilitation\"[All Fields] OR \"rehabilitations\"[All Fields] OR \"rehabilitative\"[All Fields] OR \"rehabilitation\"[MeSH Subheading] OR \"rehabilitation s\"[All Fields] OR \"rehabilitational\"[All Fields] OR \"rehabilitator\"[All Fields] OR \"rehabilitators\"[All Fields]) OR (\"physical therapy modalities\"[MeSH Terms] OR (\"physical\"[All Fields] AND \"therapy\"[All Fields] AND \"modalities\"[All Fields]) OR \"physical therapy modalities\"[All Fields] OR \"physiotherapies\"[All Fields] OR \"physiotherapy\"[All Fields]) OR (\"behavior s\"[All Fields] OR \"behaviorally\"[All Fields] OR \"behaviour\"[All Fields] OR \"behavior\"[MeSH Terms] OR \"behavior\"[All Fields] OR \"behavioural\"[All Fields] OR \"behavioral\"[All Fields] OR \"behaviourally\"[All Fields] OR \"behaviours\"[All Fields] OR \"behaviors\"[All Fields] OR \"pattern\"[All Fields] OR \"pattern s\"[All Fields] OR \"patternability\"[All Fields] OR \"patternable\"[All Fields] OR \"patterned\"[All Fields] OR \"patterning\"[All Fields] OR \"patternings\"[All Fields] OR \"patterns\"[All Fields]) OR (\"anti inflammatory agents non steroidal\"[Pharmacological Action] OR \"anti inflammatory agents non steroidal\"[Supplementary Concept] OR \"anti inflammatory agents non steroidal\"[All Fields] OR \"nsaid\"[All Fields] OR \"anti inflammatory agents, non steroidal\"[MeSH Terms] OR (\"anti inflammatory\"[All Fields] AND \"agents\"[All Fields] AND \"non steroidal\"[All Fields]) OR \"non-steroidal anti-inflammatory agents\"[All Fields] OR \"nsaids\"[All Fields] OR \"nsaid s\"[All Fields]) OR (\"analgesics opioid\"[Pharmacological Action] OR \"analgesics opioid\"[Supplementary Concept] OR \"analgesics opioid\"[All Fields] OR \"opioid\"[All Fields] OR \"analgesics, opioid\"[MeSH Terms] OR (\"analgesics\"[All Fields] AND \"opioid\"[All Fields]) OR \"opioid analgesics\"[All Fields] OR \"opioids\"[All Fields] OR \"opioid s\"[All Fields]) OR (\"nonop\"[All Fields] OR \"nonoperative\"[All Fields] OR \"nonoperatively\"[All Fields])) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "150", "edat_count": "115", "union_ids": [ "40148257", "40639955", "41343348", "41468958", "41496306", "41558602", "41665984", "41732059", "41746347", "41862304", "41869743", "41883835", "41906787", "41954970", "41956901", "42006008", "42015883", "42084386", "42134260", "42235689", "42258429", "42267534", "42276752", "42284831", "42320822", "42329412", "42371634", "42404489", "42413324", "42419415", "42427268", "42473615", "42481208", "42500460", "42518330", "42535255", "42535459", "42551333", "42555525", "42560474", "42564703", "42564747", "42569384", "42570301", "42580901", "42581237", "42586858", "42600329", "42603980", "42615503", "42661508", "42662494", "42662939", "42663054", "42663629", "42664123", "42665013", "42669811", "42670051", "42675945", "42676082", "42676088", "42678619", "42679085", "42679087", "42679426", "42680183", "42683424", "42685155", "42687133", "42688083", "42688892", "42690540", "42697255", "42700197", "42700878", "42706474", "42710947", "42718399", "42719629", "42723334", "42728082", "42730496", "42730933", "42734834", "42736733", "42737010", "42739868", "42741003", "42744636", "42747539", "42748333", "42751572", "42751726", "42751845", "42755038", "42755658", "42757472", "42758004", "42758323", "42762487", "42765343", "42766026", "42769780", "42770858", "42775337", "42775848", "42777683", "42781821", "42785965", "42786912", "42788792", "42791940", "42792325", "42793637", "42793698", "42798430", "42798646", "42799191", "42801693", "42802597", "42803703", "42804316", "42805513", "42806201", "42806217", "42807803", "42811880", "42811977", "42812897", "42815615", "42818789", "42819576", "42821151", "42821491", "42821814", "42823843", "42824922", "42831019", "42831202", "42835223", "42835637", "42836317", "42836969", "42841972", "42844679", "42846470", "42846911", "42850192", "42850345", "42851685", "42853055", "42853189", "42853345", "42854187", "42855398", "42855434", "42855835", "42855864", "42855950", "42861160", "42862041", "42862440", "42867308", "42867926" ], "not_screened_2026_09_30": [ "40639955", "41343348", "41468958", "41558602", "41746347", "41956901", "42267534", "42320822", "42419415", "42427268", "42535255", "42535459", "42551333", "42555525", "42580901", "42581237", "42586858", "42603980", "42662494", "42662939", "42663054", "42679085", "42679087", "42679426", "42683424", "42688083", "42718399", "42719629", "42723334", "42736733", "42766026", "42775337", "42802597", "42806217", "42815615", "42818789", "42819576", "42821151", "42821491", "42821814", "42823843", "42824922", "42831019", "42831202", "42835223", "42835637", "42836317", "42836969", "42841972", "42844679", "42846470", "42846911", "42850192", "42850345", "42851685", "42853055", "42853189", "42853345", "42854187", "42855398", "42855434", "42855835", "42855864", "42855950", "42861160", "42862041", "42862440", "42867308", "42867926" ] }, { "topic": "injections-ablation", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (injection OR ablation OR basivertebral OR radiofrequency OR antibiotic)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"inject\"[All Fields] OR \"injectability\"[All Fields] OR \"injectant\"[All Fields] OR \"injectants\"[All Fields] OR \"injectate\"[All Fields] OR \"injectates\"[All Fields] OR \"injected\"[All Fields] OR \"injectible\"[All Fields] OR \"injectibles\"[All Fields] OR \"injecting\"[All Fields] OR \"injections\"[MeSH Terms] OR \"injections\"[All Fields] OR \"injectable\"[All Fields] OR \"injectables\"[All Fields] OR \"injection\"[All Fields] OR \"injects\"[All Fields] OR (\"ablate\"[All Fields] OR \"ablated\"[All Fields] OR \"ablates\"[All Fields] OR \"ablating\"[All Fields] OR \"ablation\"[All Fields] OR \"ablational\"[All Fields] OR \"ablations\"[All Fields]) OR \"basivertebral\"[All Fields] OR (\"radiofrequencies\"[All Fields] OR \"radiofrequency\"[All Fields] OR \"radiofrequent\"[All Fields]) OR (\"anti bacterial agents\"[Pharmacological Action] OR \"anti bacterial agents\"[Supplementary Concept] OR \"anti bacterial agents\"[All Fields] OR \"antibiotic\"[All Fields] OR \"anti bacterial agents\"[MeSH Terms] OR (\"anti bacterial\"[All Fields] AND \"agents\"[All Fields]) OR \"antibiotics\"[All Fields] OR \"antibiotic s\"[All Fields] OR \"antibiotical\"[All Fields])) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "24", "edat_count": "19", "union_ids": [ "42015883", "42308800", "42388563", "42471059", "42473615", "42473702", "42500814", "42553289", "42564997", "42678490", "42679087", "42679091", "42683424", "42690558", "42714274", "42729915", "42743208", "42754814", "42763742", "42765343", "42771027", "42777337", "42777683", "42804305", "42806201", "42816544", "42853189", "42862440" ], "not_screened_2026_09_30": [ "42553289", "42679087", "42679091", "42683424", "42763742", "42816544", "42853189", "42862440" ] }, { "topic": "surgery", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (fusion OR arthroplasty OR \"disc replacement\" OR reoperation)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"fusion\"[All Fields] OR \"fusions\"[All Fields] OR (\"arthroplasty\"[MeSH Terms] OR \"arthroplasty\"[All Fields] OR \"arthroplasties\"[All Fields]) OR \"disc replacement\"[All Fields] OR (\"reoperate\"[All Fields] OR \"reoperated\"[All Fields] OR \"reoperating\"[All Fields] OR \"reoperation\"[MeSH Terms] OR \"reoperation\"[All Fields] OR \"reoperations\"[All Fields] OR \"reoperative\"[All Fields] OR \"second look surgery\"[MeSH Terms] OR (\"second look\"[All Fields] AND \"surgery\"[All Fields]) OR \"second look surgery\"[All Fields])) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "39", "edat_count": "24", "union_ids": [ "38717315", "40673597", "41468578", "41636867", "41779044", "41834130", "41954970", "41984178", "41985688", "42017905", "42176466", "42235689", "42324420", "42419172", "42426267", "42456529", "42481768", "42503501", "42526050", "42535180", "42595025", "42665013", "42670602", "42677233", "42677709", "42679087", "42683537", "42690540", "42690558", "42727104", "42736121", "42752976", "42766026", "42798423", "42798646", "42824183", "42836528", "42839758", "42848213", "42853900", "42854246", "42854257", "42855423", "42855864", "42861160" ], "not_screened_2026_09_30": [ "38717315", "40673597", "41834130", "41985688", "42419172", "42456529", "42595025", "42677233", "42677709", "42679087", "42727104", "42766026", "42824183", "42836528", "42839758", "42848213", "42853900", "42854246", "42854257", "42855423", "42855864", "42861160" ] }, { "topic": "regeneration", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (cell OR regenerative OR biologic OR hydrogel OR platelet OR gene OR growth-factor)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"cells\"[MeSH Terms] OR \"cells\"[All Fields] OR \"cell\"[All Fields] OR \"regenerative\"[All Fields] OR (\"biological products\"[Supplementary Concept] OR \"biological products\"[All Fields] OR \"biologic\"[All Fields] OR \"biological products\"[MeSH Terms] OR (\"biological\"[All Fields] AND \"products\"[All Fields]) OR \"biological\"[All Fields] OR \"biology\"[MeSH Terms] OR \"biology\"[All Fields] OR \"biologicals\"[All Fields] OR \"biological factors\"[Supplementary Concept] OR \"biological factors\"[All Fields] OR \"biological factors\"[MeSH Terms] OR (\"biological\"[All Fields] AND \"factors\"[All Fields]) OR \"biologics\"[All Fields] OR \"biologically\"[All Fields]) OR (\"hydrogel s\"[All Fields] OR \"hydrogelating\"[All Fields] OR \"hydrogelation\"[All Fields] OR \"hydrogelations\"[All Fields] OR \"hydrogelator\"[All Fields] OR \"hydrogelators\"[All Fields] OR \"hydrogels\"[Supplementary Concept] OR \"hydrogels\"[All Fields] OR \"hydrogel\"[All Fields] OR \"hydrogels\"[MeSH Terms]) OR (\"blood platelets\"[MeSH Terms] OR (\"blood\"[All Fields] AND \"platelets\"[All Fields]) OR \"blood platelets\"[All Fields] OR \"platelet\"[All Fields] OR \"platelets\"[All Fields] OR \"platelet s\"[All Fields] OR \"plateletes\"[All Fields]) OR (\"genes\"[MeSH Terms] OR \"genes\"[All Fields] OR \"gene\"[All Fields]) OR (\"intercellular signaling peptides and proteins\"[Supplementary Concept] OR \"intercellular signaling peptides and proteins\"[All Fields] OR \"growth factor\"[All Fields] OR \"intercellular signaling peptides and proteins\"[MeSH Terms] OR (\"intercellular\"[All Fields] AND \"signaling\"[All Fields] AND \"peptides\"[All Fields] AND \"proteins\"[All Fields]) OR (\"growth\"[All Fields] AND \"factor\"[All Fields]))) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "123", "edat_count": "88", "union_ids": [ "41329449", "41468956", "41468958", "41496306", "41558602", "41732059", "41779044", "41990698", "42035921", "42049200", "42095050", "42105475", "42153663", "42169250", "42296781", "42308800", "42322764", "42329412", "42360113", "42370393", "42372654", "42401268", "42404489", "42413735", "42425027", "42428568", "42456529", "42462661", "42471059", "42476215", "42492879", "42500814", "42501410", "42517148", "42526050", "42526826", "42530800", "42535354", "42553289", "42559161", "42564703", "42571764", "42575212", "42595025", "42598138", "42603980", "42635937", "42659810", "42660118", "42665979", "42666099", "42668501", "42671335", "42679087", "42679091", "42679426", "42683148", "42683424", "42685933", "42688780", "42689520", "42690540", "42690558", "42691205", "42694344", "42695568", "42697416", "42703293", "42706237", "42707465", "42714274", "42717236", "42719629", "42720291", "42724059", "42726129", "42728082", "42731177", "42733772", "42733874", "42738800", "42743208", "42743872", "42744636", "42749385", "42750036", "42752976", "42753964", "42754814", "42755658", "42757472", "42759153", "42761062", "42763742", "42766036", "42774880", "42776360", "42777337", "42777683", "42778683", "42779216", "42783798", "42790727", "42792120", "42794637", "42794657", "42798950", "42801678", "42801693", "42802137", "42803180", "42804305", "42807803", "42811977", "42812589", "42812897", "42813570", "42816544", "42823843", "42824268", "42831202", "42835223", "42835960", "42840662", "42840758", "42841972", "42846521", "42852874", "42853189", "42855835", "42857979", "42861622", "42862440", "42863602", "42864749" ], "not_screened_2026_09_30": [ "41329449", "41468956", "41468958", "41558602", "41990698", "42035921", "42105475", "42153663", "42169250", "42360113", "42413735", "42425027", "42456529", "42462661", "42476215", "42530800", "42535354", "42553289", "42571764", "42575212", "42595025", "42598138", "42603980", "42659810", "42679087", "42679091", "42679426", "42683424", "42694344", "42707465", "42719629", "42724059", "42738800", "42749385", "42750036", "42759153", "42763742", "42790727", "42803180", "42816544", "42823843", "42824268", "42831202", "42835223", "42835960", "42840662", "42840758", "42841972", "42846521", "42852874", "42853189", "42855835", "42857979", "42861622", "42862440", "42863602", "42864749" ] }, { "topic": "outcomes", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (outcome OR disability OR \"quality of life\" OR MCID OR \"return to work\")", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"outcome\"[All Fields] OR \"outcomes\"[All Fields] OR (\"disabilities\"[All Fields] OR \"disability\"[All Fields] OR \"disablement\"[All Fields] OR \"disablements\"[All Fields] OR \"disabling\"[All Fields] OR \"disablity\"[All Fields] OR \"persons with disabilities\"[MeSH Terms] OR (\"persons\"[All Fields] AND \"disabilities\"[All Fields]) OR \"persons with disabilities\"[All Fields] OR \"disabled\"[All Fields]) OR \"quality of life\"[All Fields] OR \"MCID\"[All Fields] OR \"return to work\"[All Fields]) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "86", "edat_count": "63", "union_ids": [ "38717315", "38741513", "40673597", "41343348", "41468578", "41468956", "41665984", "41729208", "41779044", "41823596", "41862304", "41954970", "41985688", "42006008", "42015883", "42035921", "42219090", "42225263", "42235689", "42324420", "42404489", "42419172", "42426267", "42428568", "42435939", "42456529", "42473615", "42473702", "42503501", "42517148", "42535225", "42559161", "42562358", "42564997", "42571764", "42600329", "42659810", "42663054", "42670602", "42677233", "42677709", "42678490", "42679087", "42679091", "42683424", "42683537", "42688780", "42690540", "42691205", "42695042", "42718399", "42729915", "42730662", "42736121", "42736733", "42741378", "42744959", "42750036", "42752976", "42754814", "42755658", "42761062", "42763742", "42765343", "42770026", "42771025", "42771027", "42776675", "42777337", "42778782", "42779216", "42783798", "42798423", "42798628", "42798950", "42799080", "42801296", "42804313", "42807803", "42812897", "42815615", "42819576", "42822030", "42824183", "42835960", "42836528", "42839758", "42840662", "42841972", "42844679", "42848213", "42849550", "42852874", "42853900", "42854246", "42854257", "42855423", "42861160", "42863602" ], "not_screened_2026_09_30": [ "38717315", "40673597", "41343348", "41468956", "41729208", "41823596", "41985688", "42035921", "42419172", "42435939", "42456529", "42571764", "42659810", "42663054", "42677233", "42677709", "42679087", "42679091", "42683424", "42718399", "42730662", "42736733", "42741378", "42750036", "42763742", "42778782", "42798628", "42804313", "42815615", "42819576", "42822030", "42824183", "42835960", "42836528", "42839758", "42840662", "42841972", "42844679", "42848213", "42849550", "42852874", "42853900", "42854246", "42854257", "42855423", "42861160", "42863602" ] }, { "topic": "guidelines", "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (guideline OR consensus OR recommendation)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"low back pain\"[All Fields]) AND (\"guideline\"[Publication Type] OR \"guidelines as topic\"[MeSH Terms] OR \"guideline\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR (\"recommend\"[All Fields] OR \"recommendable\"[All Fields] OR \"recommendation\"[All Fields] OR \"recommendation s\"[All Fields] OR \"recommendations\"[All Fields] OR \"recommended\"[All Fields] OR \"recommending\"[All Fields] OR \"recommends\"[All Fields])) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "55", "edat_count": "49", "union_ids": [ "32491493", "41665984", "41812784", "41887744", "41992727", "42049200", "42191512", "42209326", "42305367", "42320822", "42399214", "42413324", "42424902", "42453003", "42473702", "42522050", "42561632", "42578611", "42657933", "42660880", "42662939", "42665847", "42676082", "42676468", "42679091", "42686182", "42687437", "42689520", "42697255", "42698475", "42700878", "42705126", "42706514", "42706569", "42710331", "42728397", "42730330", "42730933", "42733874", "42736754", "42751726", "42763742", "42769267", "42771025", "42773786", "42775848", "42785648", "42785965", "42786912", "42791943", "42793474", "42793814", "42799684", "42804295", "42804305", "42804306", "42805513", "42823645", "42835223", "42836823", "42836970", "42847400", "42849958", "42852584", "42853621", "42867926", "42869194" ], "not_screened_2026_09_30": [ "41887744", "42191512", "42209326", "42320822", "42561632", "42578611", "42660880", "42662939", "42676468", "42679091", "42686182", "42698475", "42706514", "42706569", "42763742", "42769267", "42823645", "42835223", "42836823", "42836970", "42847400", "42849958", "42852584", "42853621", "42867926", "42869194" ] }, { "topic": "biomarkers", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (biomarker OR proteomics OR metabolomics OR validation OR prediction)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"biomarker s\"[All Fields] OR \"biomarkers\"[Supplementary Concept] OR \"biomarkers\"[All Fields] OR \"biomarker\"[All Fields] OR \"biomarkers\"[MeSH Terms] OR (\"proteom\"[All Fields] OR \"proteome\"[Supplementary Concept] OR \"proteome\"[All Fields] OR \"proteome\"[MeSH Terms] OR \"proteomes\"[All Fields] OR \"proteomical\"[All Fields] OR \"proteomically\"[All Fields] OR \"proteomics\"[MeSH Terms] OR \"proteomics\"[All Fields] OR \"proteomic\"[All Fields]) OR (\"metabolome\"[MeSH Terms] OR \"metabolome\"[All Fields] OR \"metabolomes\"[All Fields] OR \"metabolomics\"[MeSH Terms] OR \"metabolomics\"[All Fields] OR \"metabolomic\"[All Fields]) OR (\"valid\"[All Fields] OR \"validate\"[All Fields] OR \"validated\"[All Fields] OR \"validates\"[All Fields] OR \"validating\"[All Fields] OR \"validation\"[All Fields] OR \"validational\"[All Fields] OR \"validations\"[All Fields] OR \"validator\"[All Fields] OR \"validators\"[All Fields] OR \"validities\"[All Fields] OR \"validity\"[All Fields]) OR (\"predict\"[All Fields] OR \"predictabilities\"[All Fields] OR \"predictability\"[All Fields] OR \"predictable\"[All Fields] OR \"predictably\"[All Fields] OR \"predicted\"[All Fields] OR \"predicting\"[All Fields] OR \"prediction\"[All Fields] OR \"predictions\"[All Fields] OR \"predictive\"[All Fields] OR \"predictively\"[All Fields] OR \"predictiveness\"[All Fields] OR \"predictives\"[All Fields] OR \"predictivities\"[All Fields] OR \"predictivity\"[All Fields] OR \"predicts\"[All Fields])) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "80", "edat_count": "51", "union_ids": [ "41468578", "41468956", "41834130", "41984178", "41985688", "41990698", "42017905", "42049200", "42061462", "42095050", "42176466", "42219090", "42235689", "42296781", "42303789", "42308800", "42322764", "42329412", "42370393", "42372654", "42401268", "42404489", "42413735", "42419172", "42456529", "42462661", "42473702", "42476215", "42500814", "42503501", "42526826", "42530800", "42535180", "42635937", "42665979", "42668501", "42671335", "42691205", "42693467", "42710426", "42718399", "42726129", "42727104", "42728082", "42729493", "42730662", "42733874", "42736733", "42738800", "42741378", "42749385", "42750036", "42754814", "42755658", "42757472", "42759153", "42761062", "42766026", "42770026", "42777337", "42777683", "42783798", "42793736", "42798646", "42799080", "42803180", "42804305", "42806201", "42807803", "42811977", "42812589", "42812897", "42815170", "42822030", "42824183", "42824268", "42831202", "42835223", "42835960", "42840662", "42840758", "42846521", "42850345", "42854246", "42862440" ], "not_screened_2026_09_30": [ "41468956", "41834130", "41985688", "41990698", "42413735", "42419172", "42456529", "42462661", "42476215", "42530800", "42693467", "42718399", "42727104", "42729493", "42730662", "42736733", "42738800", "42741378", "42749385", "42750036", "42759153", "42766026", "42803180", "42815170", "42822030", "42824183", "42824268", "42831202", "42835223", "42835960", "42840662", "42840758", "42846521", "42850345", "42854246", "42862440" ] }, { "topic": "trials", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") AND (randomized OR trial OR sham OR placebo)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields]) AND (\"random allocation\"[MeSH Terms] OR (\"random\"[All Fields] AND \"allocation\"[All Fields]) OR \"random allocation\"[All Fields] OR \"randomization\"[All Fields] OR \"randomized\"[All Fields] OR \"random\"[All Fields] OR \"randomisation\"[All Fields] OR \"randomisations\"[All Fields] OR \"randomise\"[All Fields] OR \"randomised\"[All Fields] OR \"randomising\"[All Fields] OR \"randomizations\"[All Fields] OR \"randomize\"[All Fields] OR \"randomizes\"[All Fields] OR \"randomizing\"[All Fields] OR \"randomness\"[All Fields] OR \"randoms\"[All Fields] OR (\"clinical trials as topic\"[MeSH Terms] OR (\"clinical\"[All Fields] AND \"trials\"[All Fields] AND \"topic\"[All Fields]) OR \"clinical trials as topic\"[All Fields] OR \"trial\"[All Fields] OR \"trial s\"[All Fields] OR \"trialed\"[All Fields] OR \"trialing\"[All Fields] OR \"trials\"[All Fields]) OR (\"salicylhydroxamic acid\"[Supplementary Concept] OR \"salicylhydroxamic acid\"[All Fields] OR \"sham\"[All Fields]) OR (\"placeboes\"[All Fields] OR \"placebos\"[Supplementary Concept] OR \"placebos\"[All Fields] OR \"placebo\"[All Fields] OR \"placebos\"[MeSH Terms])) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "35", "edat_count": "31", "union_ids": [ "42015883", "42105475", "42404489", "42473615", "42476215", "42683537", "42691205", "42720291", "42729915", "42733874", "42738800", "42744636", "42754814", "42766026", "42766036", "42770026", "42771027", "42777337", "42783798", "42798628", "42804305", "42804313", "42807803", "42812589", "42812897", "42815615", "42824268", "42840662", "42849550", "42852874", "42853189", "42853900", "42854257", "42855423", "42862440", "42863602" ], "not_screened_2026_09_30": [ "42105475", "42476215", "42738800", "42766026", "42798628", "42804313", "42815615", "42824268", "42840662", "42849550", "42852874", "42853189", "42853900", "42854257", "42855423", "42862440", "42863602" ] }, { "topic": "patient-experience", "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (qualitative OR \"patient experience\" OR \"patient priorities\" OR stigma OR \"lived experience\")", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"low back pain\"[All Fields]) AND (\"qualitative\"[All Fields] OR \"qualitatively\"[All Fields] OR \"qualitatives\"[All Fields] OR \"patient experience\"[All Fields] OR \"patient priorities\"[All Fields] OR (\"social stigma\"[MeSH Terms] OR (\"social\"[All Fields] AND \"stigma\"[All Fields]) OR \"social stigma\"[All Fields] OR \"stigma\"[All Fields] OR \"stigmas\"[All Fields] OR \"stigma s\"[All Fields]) OR \"lived experience\"[All Fields]) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "19", "edat_count": "17", "union_ids": [ "40455078", "41665984", "41956901", "42560474", "42633118", "42662422", "42686523", "42687133", "42706474", "42729314", "42751726", "42752440", "42753813", "42777337", "42786915", "42792325", "42804306", "42815600", "42821814", "42835637", "42849905", "42855950" ], "not_screened_2026_09_30": [ "41956901", "42633118", "42686523", "42786915", "42815600", "42821814", "42835637", "42849905", "42855950" ] }, { "topic": "safety", "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic OR \"Modic changes\" OR \"disc degeneration\") OR \"low back pain\") AND (\"red flags\" OR \"cauda equina\" OR infection OR malignancy OR \"adverse event\" OR safety)", "translation": "(\"intervertebral disc degeneration\"[All Fields] OR \"degenerative disc disease\"[All Fields] OR \"discogenic\"[All Fields] OR (\"vertebrogenic\"[All Fields] OR \"vertebrogenous\"[All Fields]) OR \"Modic changes\"[All Fields] OR \"disc degeneration\"[All Fields] OR \"low back pain\"[All Fields]) AND (\"red flags\"[All Fields] OR \"cauda equina\"[All Fields] OR (\"infect\"[All Fields] OR \"infectability\"[All Fields] OR \"infectable\"[All Fields] OR \"infectant\"[All Fields] OR \"infectants\"[All Fields] OR \"infected\"[All Fields] OR \"infecteds\"[All Fields] OR \"infectibility\"[All Fields] OR \"infectible\"[All Fields] OR \"infecting\"[All Fields] OR \"infection s\"[All Fields] OR \"infections\"[MeSH Terms] OR \"infections\"[All Fields] OR \"infection\"[All Fields] OR \"infective\"[All Fields] OR \"infectiveness\"[All Fields] OR \"infectives\"[All Fields] OR \"infectivities\"[All Fields] OR \"infects\"[All Fields] OR \"pathogenicity\"[MeSH Subheading] OR \"pathogenicity\"[All Fields] OR \"infectivity\"[All Fields]) OR (\"malign\"[All Fields] OR \"malignance\"[All Fields] OR \"malignances\"[All Fields] OR \"malignant\"[All Fields] OR \"malignants\"[All Fields] OR \"malignities\"[All Fields] OR \"malignity\"[All Fields] OR \"malignization\"[All Fields] OR \"malignized\"[All Fields] OR \"maligns\"[All Fields] OR \"neoplasms\"[MeSH Terms] OR \"neoplasms\"[All Fields] OR \"malignancies\"[All Fields] OR \"malignancy\"[All Fields]) OR \"adverse event\"[All Fields] OR (\"safety\"[MeSH Terms] OR \"safety\"[All Fields] OR \"safeties\"[All Fields])) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "74", "edat_count": "68", "union_ids": [ "29262183", "41468578", "41612848", "41834130", "41869743", "41877636", "41992727", "42012435", "42125858", "42171736", "42212961", "42225263", "42267534", "42371634", "42419970", "42434718", "42473615", "42560000", "42561091", "42561632", "42562358", "42564747", "42568668", "42571764", "42603980", "42660620", "42663054", "42677046", "42677913", "42683424", "42686523", "42688132", "42690540", "42690558", "42707465", "42710947", "42710952", "42714957", "42715237", "42719867", "42720157", "42723024", "42725211", "42730330", "42736704", "42736943", "42741512", "42742776", "42749385", "42759032", "42761062", "42761328", "42762487", "42763400", "42763742", "42765343", "42766204", "42771844", "42773786", "42775188", "42783798", "42784709", "42791943", "42793814", "42798646", "42799080", "42799684", "42805245", "42807803", "42810754", "42812241", "42812900", "42813130", "42815289", "42816544", "42819200", "42824197", "42824922", "42828463", "42829583", "42831019", "42840814", "42846521", "42849958", "42853345", "42854257", "42855423", "42855950", "42856590", "42867926", "42868624", "42869194" ], "not_screened_2026_09_30": [ "41834130", "42171736", "42267534", "42561091", "42561632", "42568668", "42571764", "42603980", "42660620", "42663054", "42683424", "42686523", "42688132", "42707465", "42714957", "42720157", "42723024", "42725211", "42749385", "42763742", "42775188", "42784709", "42812900", "42813130", "42815289", "42816544", "42819200", "42824197", "42824922", "42828463", "42829583", "42831019", "42840814", "42846521", "42849958", "42853345", "42854257", "42855423", "42855950", "42856590", "42867926", "42868624", "42869194" ] }, { "topic": "cochrane", "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"low back pain\" OR \"back pain\" OR \"intervertebral disc\" OR \"lumbar\" OR spinal OR \"sciatica\")", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"low back pain\"[All Fields] OR \"back pain\"[All Fields] OR \"intervertebral disc\"[All Fields] OR \"lumbar\"[All Fields] OR (\"spinal\"[All Fields] OR \"spinalization\"[All Fields] OR \"spinalized\"[All Fields] OR \"spinally\"[All Fields] OR \"spinals\"[All Fields]) OR \"sciatica\"[All Fields]) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "4", "edat_count": "4", "union_ids": [ "42663176", "42680183", "42741999", "42742033" ], "not_screened_2026_09_30": [ "42663176", "42741999", "42742033" ] }, { "topic": "systematic-reviews-lbp", "query": "(\"chronic low back pain\"[tiab] OR \"low back pain\"[majr]) AND (systematic review[pt] OR meta-analysis[pt] OR \"network meta-analysis\"[tiab])", "translation": "(\"chronic low back pain\"[Title/Abstract] OR \"low back pain\"[MeSH Major Topic]) AND (\"systematic review\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"network meta-analysis\"[Title/Abstract]) AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "15", "edat_count": "14", "union_ids": [ "41812784", "41869743", "42258429", "42296329", "42431130", "42546593", "42662494", "42676082", "42680183", "42688083", "42695120", "42705126", "42713377", "42714957", "42748333", "42785965", "42804306", "42823645", "42823924", "42847400" ], "not_screened_2026_09_30": [ "42296329", "42431130", "42546593", "42662494", "42688083", "42695120", "42713377", "42714957", "42823645", "42823924", "42847400" ] }, { "topic": "rcts-lbp", "query": "(\"chronic low back pain\"[tiab]) AND (randomized controlled trial[pt])", "translation": "\"chronic low back pain\"[Title/Abstract] AND \"randomized controlled trial\"[Publication Type] AND 2026/08/28:2026/10/14[Date - Publication]", "pdat_count": "12", "edat_count": "5", "union_ids": [ "41956901", "42061275", "42284831", "42371634", "42419415", "42481208", "42581237", "42615503", "42676088", "42747539", "42806217", "42855950", "42862041" ], "not_screened_2026_09_30": [ "41956901", "42419415", "42581237", "42806217", "42855950", "42862041" ] } ], "unique_unscreened_records": 239, "cochrane_result": "\"Cochrane Database Syst Rev\"[jour] AND (back pain/IVD/lumbar/spinal/sciatica) returned 4 records in window: spinal cord injury fitness, fracture prevention in men, stroke cardiorespiratory training (plus one previously screened). None addresses DDD or LBP; no new or updated Cochrane review relevant to this condition in PubMed for the window. The Cochrane Library itself (CENTRAL) is HTTP 403 and was not searched.", "europe_pmc": { "endpoint": "https://www.ebi.ac.uk/europepmc/webservices/rest/search", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR \"discogenic\" OR \"vertebrogenic\" OR \"Modic\") AND (FIRST_PDATE:[2026-08-28 TO 2026-10-14])", "hitCount": 210, "non_MED_records": [ { "source": "PMC", "id": "PMC13640139", "doi": null, "date": "2026-10-07", "title": "Gut mucosal microbiota and local intervertebral disc immunity: candidate circulating-cytokine-independent pathways informed by Mendelian randomization evidence" }, { "source": "PMC", "id": "PMC13612358", "doi": null, "date": "2026-09-26", "title": "Influence of Modic changes on short-term clinical and patient-reported outcomes after anterior cervical discectomy and fusion: a retrospective cohort study" }, { "source": "PPR", "id": "PPR1308494", "doi": "10.21203/rs.3.rs-10594563/v1", "date": "2026-08-31", "title": "Family History of Low Back Pain is Associated with occurrence of Low Back Pain, Poor Quality of Life, and Lumbar Morphometric Changes: A Cross-Sectional Study" }, { "source": "PPR", "id": "PPR1311839", "doi": "10.64898/2026.09.02.748888", "date": "2026-09-03", "title": "A novel target associated with senescence and inflammatory signaling in human intervertebral disc degeneration" }, { "source": "PMC", "id": "PMC13642720", "doi": null, "date": "2026-10-08", "title": "Iron, lipid peroxidation and discogenic pain: a redox framework for ferroptosis in intervertebral disc degeneration" }, { "source": "PMC", "id": "PMC13636325", "doi": null, "date": "2026-09-27", "title": "Stem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies" }, { "source": "PMC", "id": "PMC13635454", "doi": null, "date": "2026-09-01", "title": "Hyaluronic Acid in Spinal Disorders: A Narrative Review of Hot Spots and Research Perspectives" }, { "source": "PPR", "id": "PPR1333487", "doi": "10.21203/rs.3.rs-10854209/v1", "date": "2026-10-04", "title": "The influence of intervertebral disc vacuum phenomenon on the clinical efficacy of different approaches for lumbar spinal stenosis: a retrospective cohort study" }, { "source": "PMC", "id": "PMC13640997", "doi": null, "date": "2026-10-07", "title": "ROS-responsive biomaterial delivery of the TCM-derived small molecule coptisine protects stem cells and attenuates intervertebral disc degeneration" }, { "source": "PPR", "id": "PPR1325103", "doi": "10.64898/2026.09.18.752770", "date": "2026-09-22", "title": "Sonic Hedgehog Is An Important Regulator Of Intervertebral Disc Homeostasis And Rejuvenation" }, { "source": "PPR", "id": "PPR1330631", "doi": "10.64898/2026.09.24.26363960", "date": "2026-09-29", "title": "Prevalence and Patterns of Lumbar Spine Modic Changes Among Adult Patients with a History of Low Back Pain in the Northern Zone, Tanzania" }, { "source": "PMC", "id": "PMC13644300", "doi": null, "date": "2026-10-08", "title": "Conservative Care for L3/L4 Spondylolisthesis With Severe Stenosis in the Setting of L5 Sacralization" }, { "source": "PPR", "id": "PPR1309929", "doi": "10.21203/rs.3.rs-10748663/v1", "date": "2026-09-01", "title": "Higher exposure to antibiotics is associated with greater clinical improvement of chronic low back pain with Modic changes" }, { "source": "PMC", "id": "PMC13638544", "doi": null, "date": "2026-10-07", "title": "Editorial: Macrophages at the crossroads of fibrosis and immunosuppression" }, { "source": "PMC", "id": "PMC13639566", "doi": null, "date": "2026-10-07", "title": "Platelet-derived growth factor-BB (PDGF-BB): pathophysiological roles and therapeutic implications in aging-related diseases" }, { "source": "PMC", "id": "PMC13445118", "doi": null, "date": "2026-09-04", "title": "GLP-1 Receptor Agonists and Suicide Risk in Adults With Chronic Pain: A New User Cohort Across Multi-System EHR data" }, { "source": "PMC", "id": "PMC13578978", "doi": null, "date": "2026-09-17", "title": "When metabolic enzymes meet lactylation: a bidirectional dialogue in health and disease" }, { "source": "PMC", "id": "PMC13636486", "doi": null, "date": "2026-10-01", "title": "EP4.18 F-FDG PET/MRI Identifies Previously Unrecognized Pain Generators in Patients with Persistent Pain After Hip Surgery" }, { "source": "PPR", "id": "PPR1316448", "doi": "10.21203/rs.3.rs-10748711/v1", "date": "2026-09-10", "title": "Assay sensitivity and the interpretation of culture-based disc microbiology studies: a scoping review" }, { "source": "PMC", "id": "PMC13445214", "doi": null, "date": "2026-09-04", "title": "Gender Differences in the Motivations for Suicide Attempts Among Cases Presenting to the Emergency Department: A Retrospective Study" }, { "source": "PMC", "id": "PMC13649347", "doi": null, "date": "2026-10-08", "title": "Multidimensional Management of Degenerative Scoliosis: A Comprehensive Narrative Review Integrating Diagnostic Assessment, Surgical Decision\u2010Making, and Patient\u2010Centered Outcomes" }, { "source": "PMC", "id": "PMC13646832", "doi": null, "date": "2026-10-01", "title": "Evaluation of Changes in Spinal Posture Following Fluoroscopy-Guided Transforaminal Epidural Steroid Injection in Chronic Low Back Pain using the DIERS Formetric 4D Spine Posture Analysis System: A Prospective Observational Study" }, { "source": "PMC", "id": "PMC13650467", "doi": null, "date": "2026-10-10", "title": "A pre-market, open-label, single-arm study to evaluate b.Bone for posterolateral fusion treatment of degenerative thoracolumbar, lumbar or lumbosacral spinal disease (b.Spine clinical trial)" }, { "source": "PMC", "id": "PMC13638388", "doi": null, "date": "2026-10-07", "title": "Enhancing therapeutic outcomes in degenerative lumbar disc disease: a retrospective study on combined autologous PRP injection and celecoxib therapy" }, { "source": "PMC", "id": "PMC12562739", "doi": null, "date": "2026-09-04", "title": "Industry updates from the field of stem cell research and regenerative medicine in June 2025" }, { "source": "PMC", "id": "PMC13636655", "doi": null, "date": "2026-10-01", "title": "Structural compression and entorhinal vulnerability: Linking tentorial adjacency to tau burden and dementia progression" }, { "source": "PMC", "id": "PMC13645754", "doi": null, "date": "2026-10-09", "title": "Association between preoperative controlling nutritional status score and surgical site infection following instrumented posterior lumbar interbody fusion" }, { "source": "PMC", "id": "PMC13648590", "doi": null, "date": "2026-09-30", "title": "THE MICROANATOMY OF INTRACRANIAL HUMAN THROMBI BY SINGLE NUCLEI TRANSCRIPTOMICS" }, { "source": "PMC", "id": "PMC13616780", "doi": null, "date": "2026-09-29", "title": "Adipose-derived mesenchymal stem cell-exosomes attenuate lipopolysaccharide-induced acute lung injury in mice by regulating the TGFBR2/Smad4 axis to suppress NLRP3-mediated macrophage M1 polarization and pyroptosis" }, { "source": "PMC", "id": "PMC13639544", "doi": null, "date": "2026-10-01", "title": "Multifunctional Hydrogels: Rational Design and Application in Regenerative Medicine" }, { "source": "PMC", "id": "PMC13643697", "doi": null, "date": "2026-10-08", "title": "Research progress in clinical utilization of H2 as a pleiotropic agent" }, { "source": "PMC", "id": "PMC13641234", "doi": null, "date": "2026-09-01", "title": "Abstracts of Scientific Presentations: 2026 AALAS National Meeting Houston, Texas" } ], "outcome": "No non-MEDLINE record retained. Preprints noted for follow-up only: PPR1309929 (Research Square, antibiotic exposure-response meta-regression in Modic cLBP, doi:10.21203/rs.3.rs-10748663/v1); PPR1316448 (culture-based disc microbiology assay sensitivity scoping review, doi:10.21203/rs.3.rs-10748711/v1); PPR1330631 (Modic prevalence, northern Tanzania)." }, "retraction_checks": { "method": "PubMed PublicationType + CommentsCorrections (RetractionIn/ExpressionOfConcernIn) via EFetch; Crossref /works/{doi} updated-by (no mailto; LIFEBANK_CONTACT_EMAIL unset, Unpaywall skipped)", "records": { "42660880": "clean", "42852874": "clean", "42834228": "clean", "42713377": "clean", "42863602": "clean", "42821814": "clean" } }, "retained_papers": [ { "pmid": "42660880", "use": "guidelines.md, injections page, REGISTRY.md; full text verified" }, { "pmid": "42852874", "use": "injections, regenerative, guidelines pages; STATISTICS; OQ-14; abstract-level" }, { "pmid": "42834228", "use": "STATISTICS; full text figures" }, { "pmid": "42713377", "use": "STATISTICS; abstract-level" }, { "pmid": "42863602", "use": "bibliography-only" }, { "pmid": "42821814", "use": "patient-voice sources; abstract-level" } ], "trial_record_endpoint": "https://clinicaltrials.gov/api/v2/studies/{nct}", "trial_snapshots": [ { "nct": "NCT00394732", "status": "COMPLETED", "lastUpdate": "2012-10-12", "resultsFirstPost": null, "hasResults": false, "completion": "2007-09", "primaryCompletion": "2007-09" }, { "nct": "NCT00493558", "status": "COMPLETED", "lastUpdate": "2013-02-20", "resultsFirstPost": null, "hasResults": false, "completion": "2012-06", "primaryCompletion": "2012-06" }, { "nct": "NCT01299077", "status": "COMPLETED", "lastUpdate": "2011-12-28", "resultsFirstPost": "2011-11-28", "hasResults": true, "completion": "2010-11", "primaryCompletion": "2010-09" }, { "nct": "NCT01502644", "status": "COMPLETED", "lastUpdate": "2017-07-11", "resultsFirstPost": "2017-06-08", "hasResults": true, "completion": "2013-01", "primaryCompletion": "2013-01" }, { "nct": "NCT01643681", "status": "WITHDRAWN", "lastUpdate": "2019-06-05", "resultsFirstPost": null, "hasResults": false, "completion": "2015-12", "primaryCompletion": "2014-03" }, { "nct": "NCT02983747", "status": "UNKNOWN", "lastUpdate": "2022-05-09", "resultsFirstPost": null, "hasResults": false, "completion": "2022-12-30", "primaryCompletion": "2022-12-30" }, { "nct": "NCT03002207", "status": "COMPLETED", "lastUpdate": "2024-12-27", "resultsFirstPost": null, "hasResults": false, "completion": "2024-12-22", "primaryCompletion": "2024-12-20" }, { "nct": "NCT03040310", "status": "COMPLETED", "lastUpdate": "2018-02-08", "resultsFirstPost": null, "hasResults": false, "completion": "2017-09", "primaryCompletion": "2017-09" }, { "nct": "NCT03415828", "status": "RECRUITING", "lastUpdate": "2025-09-29", "resultsFirstPost": null, "hasResults": false, "completion": "2027-05-29", "primaryCompletion": "2024-02-29" }, { "nct": "NCT03461458", "status": "TERMINATED", "lastUpdate": "2022-01-25", "resultsFirstPost": null, "hasResults": false, "completion": "2021-02-06", "primaryCompletion": "2021-02-06" }, { "nct": "NCT03674190", "status": "WITHDRAWN", "lastUpdate": "2020-12-16", "resultsFirstPost": null, "hasResults": false, "completion": "2022-10", "primaryCompletion": "2020-10" }, { "nct": "NCT03737461", "status": "ACTIVE_NOT_RECRUITING", "lastUpdate": "2025-09-30", "resultsFirstPost": null, "hasResults": false, "completion": "2026-03-08", "primaryCompletion": "2022-05-30" }, { "nct": "NCT03912454", "status": "UNKNOWN", "lastUpdate": "2022-03-16", "resultsFirstPost": null, "hasResults": false, "completion": "2022-09", "primaryCompletion": "2022-09" }, { "nct": "NCT03955315", "status": "COMPLETED", "lastUpdate": "2025-11-20", "resultsFirstPost": null, "hasResults": false, "completion": "2022-11-28", "primaryCompletion": "2022-02-01" }, { "nct": "NCT03958604", "status": "COMPLETED", "lastUpdate": "2024-11-19", "resultsFirstPost": null, "hasResults": false, "completion": "2021-12-31", "primaryCompletion": "2021-12-31" }, { "nct": "NCT04104412", "status": "RECRUITING", "lastUpdate": "2026-04-23", "resultsFirstPost": null, "hasResults": false, "completion": "2027-06-30", "primaryCompletion": "2026-12-31" }, { "nct": "NCT04414592", "status": "UNKNOWN", "lastUpdate": "2020-06-04", "resultsFirstPost": null, "hasResults": false, "completion": "2023-03", "primaryCompletion": "2022-03" }, { "nct": "NCT04417855", "status": "COMPLETED", "lastUpdate": "2020-08-11", "resultsFirstPost": null, "hasResults": false, "completion": "2020-08-04", "primaryCompletion": "2020-07-20" }, { "nct": "NCT04544709", "status": "TERMINATED", "lastUpdate": "2023-12-11", "resultsFirstPost": "2023-12-11", "hasResults": true, "completion": "2022-07-29", "primaryCompletion": "2022-07-29" }, { "nct": "NCT04600544", "status": "COMPLETED", "lastUpdate": "2024-12-24", "resultsFirstPost": null, "hasResults": false, "completion": "2024-12-10", "primaryCompletion": "2022-10-19" }, { "nct": "NCT04641039", "status": "RECRUITING", "lastUpdate": "2026-04-22", "resultsFirstPost": null, "hasResults": false, "completion": "2029-12-28", "primaryCompletion": "2029-12-28" }, { "nct": "NCT04934917", "status": "TERMINATED", "lastUpdate": "2022-09-30", "resultsFirstPost": null, "hasResults": false, "completion": "2021-07-01", "primaryCompletion": "2021-07-01" }, { "nct": "NCT05066334", "status": "UNKNOWN", "lastUpdate": "2025-05-25", "resultsFirstPost": null, "hasResults": false, "completion": "2025-10-31", "primaryCompletion": "2025-10-31" }, { "nct": "NCT05105490", "status": "WITHDRAWN", "lastUpdate": "2025-05-21", "resultsFirstPost": null, "hasResults": false, "completion": "2021-12-31", "primaryCompletion": "2021-12-31" }, { "nct": "NCT05182489", "status": "ACTIVE_NOT_RECRUITING", "lastUpdate": "2026-02-25", "resultsFirstPost": null, "hasResults": false, "completion": "2026-04-01", "primaryCompletion": "2025-10-01" }, { "nct": "NCT05207813", "status": "COMPLETED", "lastUpdate": "2025-05-08", "resultsFirstPost": "2025-05-08", "hasResults": true, "completion": "2024-02-01", "primaryCompletion": "2024-02-01" }, { "nct": "NCT05287867", "status": "RECRUITING", "lastUpdate": "2025-04-06", "resultsFirstPost": null, "hasResults": false, "completion": "2026-12-31", "primaryCompletion": "2026-12-31" }, { "nct": "NCT05326594", "status": "COMPLETED", "lastUpdate": "2024-02-28", "resultsFirstPost": null, "hasResults": false, "completion": "2023-06-30", "primaryCompletion": "2023-06-30" }, { "nct": "NCT05614284", "status": "TERMINATED", "lastUpdate": "2025-11-28", "resultsFirstPost": null, "hasResults": false, "completion": "2024-05-16", "primaryCompletion": "2024-05-16" }, { "nct": "NCT05692440", "status": "UNKNOWN", "lastUpdate": "2024-03-21", "resultsFirstPost": null, "hasResults": false, "completion": "2026-06-01", "primaryCompletion": "2026-01-01" }, { "nct": "NCT06011551", "status": "RECRUITING", "lastUpdate": "2026-09-18", "resultsFirstPost": null, "hasResults": false, "completion": "2028-12-31", "primaryCompletion": "2027-12-31" }, { "nct": "NCT06053242", "status": "ACTIVE_NOT_RECRUITING", "lastUpdate": "2026-08-21", "resultsFirstPost": null, "hasResults": false, "completion": "2027-08-20", "primaryCompletion": "2027-01-20" }, { "nct": "NCT06144970", "status": "NOT_YET_RECRUITING", "lastUpdate": "2026-08-20", "resultsFirstPost": null, "hasResults": false, "completion": "2029-07-28", "primaryCompletion": "2028-07-28" }, { "nct": "NCT06325566", "status": "ACTIVE_NOT_RECRUITING", "lastUpdate": "2026-06-17", "resultsFirstPost": null, "hasResults": false, "completion": "2028-07", "primaryCompletion": "2027-07" }, { "nct": "NCT06589271", "status": "SUSPENDED", "lastUpdate": "2026-04-27", "resultsFirstPost": null, "hasResults": false, "completion": "2027-12-31", "primaryCompletion": "2027-06-30" }, { "nct": "NCT06611397", "status": "RECRUITING", "lastUpdate": "2026-10-02", "resultsFirstPost": null, "hasResults": false, "completion": "2027-08-30", "primaryCompletion": "2026-12-31" }, { "nct": "NCT06615505", "status": "ACTIVE_NOT_RECRUITING", "lastUpdate": "2026-10-05", "resultsFirstPost": null, "hasResults": false, "completion": "2027-11", "primaryCompletion": "2026-02-06" }, { "nct": "NCT06703671", "status": "RECRUITING", "lastUpdate": "2026-02-04", "resultsFirstPost": null, "hasResults": false, "completion": "2026-06-01", "primaryCompletion": "2026-06-01" }, { "nct": "NCT06709391", "status": "RECRUITING", "lastUpdate": "2026-09-08", "resultsFirstPost": null, "hasResults": false, "completion": "2037-12", "primaryCompletion": "2030-12" }, { "nct": "NCT06778447", "status": "RECRUITING", "lastUpdate": "2026-09-14", "resultsFirstPost": null, "hasResults": false, "completion": "2028-10", "primaryCompletion": "2027-10" }, { "nct": "NCT07011537", "status": "ENROLLING_BY_INVITATION", "lastUpdate": "2026-01-23", "resultsFirstPost": null, "hasResults": false, "completion": "2026-07", "primaryCompletion": "2026-06" }, { "nct": "NCT07137559", "status": "AVAILABLE", "lastUpdate": "2025-08-22", "resultsFirstPost": null, "hasResults": false, "completion": null, "primaryCompletion": null }, { "nct": "NCT07168603", "status": "RECRUITING", "lastUpdate": "2026-04-03", "resultsFirstPost": null, "hasResults": false, "completion": "2027-02-01", "primaryCompletion": "2026-12-01" }, { "nct": "NCT07254806", "status": "RECRUITING", "lastUpdate": "2026-09-23", "resultsFirstPost": null, "hasResults": false, "completion": "2028-11-24", "primaryCompletion": "2027-11-24" }, { "nct": "NCT07386548", "status": "RECRUITING", "lastUpdate": "2026-07-29", "resultsFirstPost": null, "hasResults": false, "completion": "2030-12", "primaryCompletion": "2030-01" }, { "nct": "NCT07392333", "status": "RECRUITING", "lastUpdate": "2026-06-18", "resultsFirstPost": null, "hasResults": false, "completion": "2027-11-30", "primaryCompletion": "2027-01-31" }, { "nct": "NCT07433634", "status": "RECRUITING", "lastUpdate": "2026-03-03", "resultsFirstPost": null, "hasResults": false, "completion": "2026-10", "primaryCompletion": "2026-10" }, { "nct": "NCT07648927", "status": "NOT_YET_RECRUITING", "lastUpdate": "2026-06-16", "resultsFirstPost": null, "hasResults": false, "completion": "2026-09-10", "primaryCompletion": "2026-08-25" }, { "nct": "NCT07668466", "status": "NOT_YET_RECRUITING", "lastUpdate": "2026-06-25", "resultsFirstPost": null, "hasResults": false, "completion": "2030-12-01", "primaryCompletion": "2028-08-31" } ], "trial_changes_vs_2026_09_30": { "status_changes": [], "results_changes": [], "last_update_changes": { "NCT06611397": "2026-04-09 -> 2026-10-02 (enrollment field 5 ESTIMATED; summary still says 40 evaluable)", "NCT06615505": "2026-06-16 -> 2026-10-05 (primary completion ACTUAL 2026-02-06; no results)" } }, "trial_discovery": [ { "params": { "query.cond": "Degenerative Disc Disease", "filter.advanced": "AREA[LastUpdatePostDate]RANGE[2026-09-30,2026-10-14]", "pageSize": 100 }, "totalReturned": 7, "nextPageToken": null }, { "params": { "query.term": "discogenic OR vertebrogenic OR \"intervertebral disc degeneration\" OR \"Modic\"", "filter.advanced": "AREA[LastUpdatePostDate]RANGE[2026-09-30,2026-10-14]", "pageSize": 100 }, "totalReturned": 10, "nextPageToken": null } ], "trials_added": [ "NCT04652687", "NCT06827262" ], "isrctn": { "endpoint": "https://www.isrctn.com/api/query/format/default?q=disc%20degeneration%20OR%20discogenic%20OR%20Modic&limit=100", "totalCount": 52, "updated_in_window": [ "ISRCTN75650267", "ISRCTN48471661", "ISRCTN55506796", "ISRCTN13615218", "ISRCTN96250868", "ISRCTN88711666", "ISRCTN95654194" ], "outcome": "None is a lumbar disc-degeneration trial (perioperative antibiotics, cervical cage, cauda equina recognition, deformity implant, ophthalmology)." }, "who_ictrp": "Portal HTTP 200 but JavaScript-driven; not searched programmatically.", "web_checks": { "https://www.nice.org.uk/guidance/ng59/chapter/Update-information": "200; Last updated 29 July 2026; psychological therapy (1.2.13) and combined programmes (1.2.14) withdrawn", "https://www.painmed.org/clinical-guidelines/": "200; 'Coming Soon' no longer present; links acute LBP guideline pages", "https://www.painmed.org/acute-low-back-pain-clinicians": "200; key recommendations summary", "https://backcare.org.uk/news/back-care-awareness-week-2026-5th-to-10th-october/": "200; booklet not yet linked", "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13522480/fullTextXML": "200; Gao 2026 full text", "https://www.nature.com/articles/s41591-026-04696-w": "200; Fillingim 2026 full text", "https://onlinelibrary.wiley.com/doi/full/10.1002/pmrj.70216": "403" }, "not_searched": [ "Cochrane Library / CENTRAL (HTTP 403)", "SciELO / LILACS (HTTP 403)", "Embase/Scopus/WoS (no credentials)", "Unpaywall (no LIFEBANK_CONTACT_EMAIL)", "OpenAlex, DOAJ (not used this sweep)" ], "independent_audit_completed": false }