{ "condition": "degenerative-disc-disease", "retrieved_on": "2026-09-30", "publication_window_inclusive": [ "2026-08-28", "2026-09-30" ], "author": "Codex", "verification_level": "Live ESearch/EFetch metadata and abstracts; API v2 registry records. Independent audit pending.", "pubmed_searches": [ { "topic": "overview", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic)", "count": "132", "ids": [ "42813570", "42812897", "42812589", "42811977", "42807803", "42806201", "42804305", "42802137", "42801693", "42801678", "42801296", "42799080", "42798950", "42798646", "42798423", "42794657", "42794637", "42793736", "42792120", "42783798", "42779216", "42778683", "42777683", "42777337", "42776675", "42776360", "42774880", "42771027", "42771025", "42770026", "42766036", "42765343", "42761062", "42757472", "42755658", "42753964", "42752976", "42744959", "42744636", "42743872", "42743208", "42736121", "42733874", "42733772", "42733314", "42731177", "42729915", "42728082", "42726129", "42720291", "42717236", "42714274", "42710426", "42706237", "42703293", "42699943", "42697416", "42695568", "42695042", "42693219", "42691205", "42690558", "42690540", "42689520", "42688780", "42685933", "42683537", "42683148", "42678973", "42678490", "42675945", "42671335", "42670602", "42668501", "42666099", "42665979", "42665013", "42660118", "42635937", "42600329", "42564997", "42564703", "42562358", "42559161", "42535225", "42535180", "42526826", "42526050", "42517148", "42503501", "42501410", "42500814", "42492879", "42481768", "42473702", "42473615", "42471059", "42428568", "42426267", "42404489", "42401268", "42388563", "42372654", "42370393", "42329412", "42324420", "42322764", "42308800", "42303789", "42296781", "42235689", "42234095", "42225263", "42219090", "42176466", "42095050", "42061462", "42049200", "42017905", "42015883", "42006008", "41984178", "41954970", "41862304", "41779044", "41732059", "41665984", "41636867", "41559863", "41496306", "41468578", "38741513" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "epidemiology", "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) OR \"low back pain\") AND (epidemiology OR prevalence OR incidence OR burden OR registry OR \"natural history\")", "count": "115", "ids": [ "42805513", "42804297", "42801130", "42798423", "42796083", "42794657", "42793736", "42793573", "42788574", "42786905", "42785965", "42785648", "42781724", "42779894", "42777337", "42777078", "42775848", "42773786", "42771844", "42771047", "42771025", "42770026", "42767531", "42766617", "42766036", "42766023", "42765774", "42765154", "42762713", "42762487", "42759032", "42758323", "42758004", "42755755", "42755474", "42754814", "42753813", "42752976", "42752440", "42747017", "42744959", "42743872", "42741512", "42739868", "42739707", "42739658", "42737010", "42736986", "42736943", "42736121", "42734834", "42733749", "42733314", "42732048", "42729952", "32491493", "42723300", "42714274", "42713388", "42712230", "42710331", "42706474", "42700878", "42698699", "42697255", "42696314", "42695042", "42693219", "42691719", "42691205", "42688837", "42688780", "42687133", "42680183", "42680080", "42679904", "42678973", "42671763", "42670602", "42670051", "42668501", "42663634", "42661508", "42571275", "42570301", "42526050", "42522050", "42481768", "42473615", "42434718", "42419970", "42419416", "42413324", "42385546", "42324420", "42303789", "42301237", "42225263", "42219090", "42176466", "42108930", "42095615", "42083926", "42061764", "42061275", "42015883", "42006008", "41954970", "41877636", "41779044", "41732059", "41559863", "41326201", "40586351", "40148257" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+OR+%22low+back+pain%22%29+AND+%28epidemiology+OR+prevalence+OR+incidence+OR+burden+OR+registry+OR+%22natural+history%22%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "anatomy-biomechanics", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) AND (biomechanics OR endplate OR nutrition OR loading)", "count": "34", "ids": [ "42807803", "42801678", "42798423", "42783798", "42779216", "42777683", "42777337", "42771027", "42765343", "42753964", "42744959", "42733772", "42728082", "42703293", "42695568", "42695042", "42693219", "42691205", "42678490", "42668501", "42665013", "42564703", "42559161", "42526826", "42526050", "42503501", "42492879", "42481768", "42303789", "42225263", "42219090", "42095050", "42015883", "41496306" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+AND+%28biomechanics+OR+endplate+OR+nutrition+OR+loading%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "cell-biology", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) AND (senescence OR inflammation OR ferroptosis OR molecular OR \"single cell\" OR transcriptomics)", "count": "58", "ids": [ "42812589", "42811977", "42807803", "42801693", "42801678", "42794657", "42794637", "42778683", "42777683", "42776360", "42774880", "42771027", "42771025", "42766036", "42761062", "42757472", "42755658", "42744959", "42743872", "42733874", "42733772", "42728082", "42726129", "42720291", "42706237", "42703293", "42697416", "42691205", "42689520", "42688780", "42685933", "42683148", "42678490", "42671335", "42668501", "42666099", "42665979", "42660118", "42564703", "42559161", "42517148", "42501410", "42500814", "42492879", "42471059", "42428568", "42404489", "42401268", "42372654", "42370393", "42329412", "42322764", "42308800", "42296781", "42095050", "42049200", "41732059", "41496306" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+AND+%28senescence+OR+inflammation+OR+ferroptosis+OR+molecular+OR+%22single+cell%22+OR+transcriptomics%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "genetics-risk", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) AND (genetic OR GWAS OR smoking OR obesity OR occupational OR risk)", "count": "40", "ids": [ "42811977", "42804305", "42801296", "42799080", "42793736", "42783798", "42777337", "42776360", "42771025", "42770026", "42752976", "42744959", "42744636", "42706237", "42689520", "42688780", "42683537", "42671335", "42670602", "42660118", "42559161", "42526050", "42517148", "42481768", "42426267", "42401268", "42372654", "42370393", "42329412", "42324420", "42308800", "42225263", "42176466", "42061462", "42017905", "41984178", "41954970", "41779044", "41636867", "41468578" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+AND+%28genetic+OR+GWAS+OR+smoking+OR+obesity+OR+occupational+OR+risk%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "imaging-diagnosis", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) AND (MRI OR imaging OR Modic OR Pfirrmann OR discography OR diagnosis)", "count": "58", "ids": [ "42807803", "42806201", "42804305", "42801693", "42799080", "42798423", "42793736", "42792120", "42779216", "42777337", "42771025", "42765343", "42755658", "42744959", "42744636", "42736121", "42733772", "42733314", "42729915", "42720291", "42710426", "42699943", "42695042", "42693219", "42678973", "42678490", "42675945", "42666099", "42665013", "42600329", "42564997", "42564703", "42562358", "42535225", "42526826", "42526050", "42517148", "42501410", "42500814", "42481768", "42473702", "42428568", "42426267", "42404489", "42388563", "42324420", "42303789", "42234095", "42219090", "42176466", "42061462", "42017905", "42015883", "41984178", "41862304", "41559863", "41468578", "38741513" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+AND+%28MRI+OR+imaging+OR+Modic+OR+Pfirrmann+OR+discography+OR+diagnosis%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "conservative", "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) OR \"chronic low back pain\") AND (exercise OR rehabilitation OR physiotherapy OR behavioral OR NSAID OR opioid OR nonoperative)", "count": "95", "ids": [ "42812897", "42811977", "42811880", "42807803", "42806201", "42805513", "42804316", "42803703", "42801693", "42799191", "42798646", "42798430", "42793698", "42793637", "42792325", "42791940", "42788792", "42786912", "42785965", "42781821", "42775848", "42770858", "42769780", "42765343", "42762487", "42758323", "42758004", "42757472", "42755658", "42755038", "42751845", "42751726", "42751572", "42748333", "42747539", "42744636", "42741003", "42739868", "42737010", "42734834", "42730933", "42730496", "42728082", "42710947", "42706474", "42700878", "42700197", "42697255", "42690540", "42688892", "42687133", "42685155", "42680183", "42678619", "42676088", "42676082", "42675945", "42670051", "42669811", "42665013", "42664123", "42663629", "42661508", "42615503", "42600329", "42570301", "42569384", "42564747", "42564703", "42560474", "42518330", "42500460", "42481208", "42473615", "42413324", "42404489", "42371634", "42329412", "42284831", "42276752", "42258429", "42235689", "42134260", "42084386", "42015883", "42006008", "41954970", "41906787", "41883835", "41869743", "41862304", "41732059", "41665984", "41496306", "40148257" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+OR+%22chronic+low+back+pain%22%29+AND+%28exercise+OR+rehabilitation+OR+physiotherapy+OR+behavioral+OR+NSAID+OR+opioid+OR+nonoperative%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "injections-ablation", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) AND (injection OR ablation OR basivertebral OR radiofrequency OR antibiotic)", "count": "19", "ids": [ "42806201", "42804305", "42777683", "42777337", "42771027", "42765343", "42743208", "42729915", "42714274", "42690558", "42678490", "42564997", "42500814", "42473702", "42473615", "42471059", "42388563", "42308800", "42015883" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+AND+%28injection+OR+ablation+OR+basivertebral+OR+radiofrequency+OR+antibiotic%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "surgery", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) AND (fusion OR arthroplasty OR \"disc replacement\" OR reoperation)", "count": "23", "ids": [ "42798646", "42798423", "42752976", "42736121", "42690558", "42690540", "42683537", "42670602", "42665013", "42535180", "42526050", "42503501", "42481768", "42426267", "42324420", "42235689", "42176466", "42017905", "41984178", "41954970", "41779044", "41636867", "41468578" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+AND+%28fusion+OR+arthroplasty+OR+%22disc+replacement%22+OR+reoperation%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "regeneration", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) AND (cell OR regenerative OR biologic OR hydrogel OR platelet OR gene OR growth-factor)", "count": "77", "ids": [ "42813570", "42812897", "42812589", "42811977", "42807803", "42804305", "42802137", "42801693", "42801678", "42798950", "42794657", "42794637", "42792120", "42783798", "42779216", "42778683", "42777683", "42777337", "42776360", "42774880", "42766036", "42761062", "42757472", "42755658", "42753964", "42752976", "42744636", "42743872", "42743208", "42733874", "42733772", "42731177", "42728082", "42726129", "42720291", "42717236", "42714274", "42706237", "42703293", "42697416", "42695568", "42691205", "42690558", "42690540", "42689520", "42688780", "42685933", "42683148", "42671335", "42668501", "42666099", "42665979", "42660118", "42635937", "42564703", "42559161", "42526826", "42526050", "42517148", "42501410", "42500814", "42492879", "42471059", "42428568", "42404489", "42401268", "42372654", "42370393", "42329412", "42322764", "42308800", "42296781", "42095050", "42049200", "41779044", "41732059", "41496306" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+AND+%28cell+OR+regenerative+OR+biologic+OR+hydrogel+OR+platelet+OR+gene+OR+growth-factor%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "outcomes", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) AND (outcome OR disability OR \"quality of life\" OR MCID OR \"return to work\")", "count": "52", "ids": [ "42812897", "42807803", "42801296", "42799080", "42798950", "42798423", "42783798", "42779216", "42777337", "42776675", "42771027", "42771025", "42770026", "42765343", "42761062", "42755658", "42752976", "42744959", "42736121", "42729915", "42695042", "42691205", "42690540", "42688780", "42683537", "42678490", "42670602", "42600329", "42564997", "42562358", "42559161", "42535225", "42517148", "42503501", "42473702", "42473615", "42428568", "42426267", "42404489", "42324420", "42235689", "42225263", "42219090", "42015883", "42006008", "41954970", "41862304", "41779044", "41665984", "41496306", "41468578", "38741513" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+AND+%28outcome+OR+disability+OR+%22quality+of+life%22+OR+MCID+OR+%22return+to+work%22%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "guidelines", "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) OR \"low back pain\") AND (guideline OR consensus OR recommendation)", "count": "41", "ids": [ "42805513", "42804306", "42804305", "42804295", "42799684", "42793814", "42793474", "42791943", "42786912", "42785965", "42785648", "42775848", "42773786", "42771025", "42751726", "42736754", "42733874", "42730933", "42730330", "42728397", "32491493", "42710331", "42705126", "42700878", "42697255", "42689520", "42687437", "42676082", "42665847", "42657933", "42522050", "42473702", "42453003", "42424902", "42413324", "42399214", "42305367", "42049200", "41992727", "41812784", "41665984" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+OR+%22low+back+pain%22%29+AND+%28guideline+OR+consensus+OR+recommendation%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "biomarkers", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) AND (biomarker OR proteomics OR metabolomics OR validation OR prediction)", "count": "49", "ids": [ "42812897", "42812589", "42811977", "42807803", "42806201", "42804305", "42799080", "42798646", "42793736", "42783798", "42777683", "42777337", "42770026", "42761062", "42757472", "42755658", "42733874", "42728082", "42726129", "42710426", "42691205", "42671335", "42668501", "42665979", "42635937", "42535180", "42526826", "42503501", "42500814", "42473702", "42404489", "42401268", "42372654", "42370393", "42329412", "42322764", "42308800", "42303789", "42296781", "42235689", "42219090", "42176466", "42095050", "42061462", "42049200", "42017905", "41984178", "41496306", "41468578" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+AND+%28biomarker+OR+proteomics+OR+metabolomics+OR+validation+OR+prediction%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "trials", "query": "(\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) AND (randomized OR trial OR sham OR placebo)", "count": "19", "ids": [ "42812897", "42812589", "42807803", "42804305", "42783798", "42777337", "42771027", "42770026", "42766036", "42744636", "42733874", "42729915", "42720291", "42691205", "42683537", "42473615", "42404489", "42015883", "41496306" ], "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi?db=pubmed&term=%28%22intervertebral+disc+degeneration%22+OR+%22degenerative+disc+disease%22+OR+discogenic+OR+vertebrogenic%29+AND+%28randomized+OR+trial+OR+sham+OR+placebo%29&retmode=json&retmax=1000&mindate=2026%2F08%2F28&maxdate=2026%2F09%2F30&datetype=pdat" }, { "topic": "patient-experience", "query": "((\"intervertebral disc degeneration\" OR \"degenerative disc disease\" OR discogenic OR vertebrogenic) OR \"low back pain\") AND (qualitative OR \"patient experience\" OR \"patient priorities\" OR stigma OR \"lived experience\")", "count": "13", "ids": [ "42804306", "42792325", "42777337", "42753813", "42752440", "42751726", "42729314", "42706474", "42687133", "42662422", "42560474", "41665984", "40455078" ], "url": 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"nct": "NCT07392333", "title": "A Prospective Cohort Study of Basivertebral Nerve Ablation Using the Stryker OptaBlate BVN System for the Treatment of Vertebrogenic Low Back Pain", "status": "RECRUITING", "lastUpdate": { "date": "2026-06-18", "type": "ACTUAL" }, "resultsFirstPost": null, "hasResults": false, "resultsSection": false, "completion": { "date": "2027-11-30", "type": "ESTIMATED" } }, { "nct": "NCT07433634", "title": "Time to BBVNA Relief", "status": "RECRUITING", "lastUpdate": { "date": "2026-03-03", "type": "ACTUAL" }, "resultsFirstPost": null, "hasResults": false, "resultsSection": false, "completion": { "date": "2026-10", "type": "ESTIMATED" } }, { "nct": "NCT07648927", "title": "Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging Findings", "status": "NOT_YET_RECRUITING", "lastUpdate": { "date": "2026-06-16", "type": "ACTUAL" }, "resultsFirstPost": null, "hasResults": false, "resultsSection": false, "completion": { "date": "2026-09-10", "type": "ESTIMATED" } }, { "nct": "NCT07668466", "title": "Intradiscal rhGDF-6 for the Treatment of Lumbar Disc Degeneration", "status": "NOT_YET_RECRUITING", "lastUpdate": { "date": "2026-06-25", "type": "ACTUAL" }, "resultsFirstPost": null, "hasResults": false, "resultsSection": false, "completion": { "date": "2030-12-01", "type": "ESTIMATED" } }, { "nct": "NCT06709391", "title": "Fusion or Not - a Study on Low Back Pain", "status": "RECRUITING", "lastUpdate": { "date": "2026-09-08", "type": "ACTUAL" }, "resultsFirstPost": null, "hasResults": false, "resultsSection": false, "completion": { "date": "2037-12", "type": "ESTIMATED" }, "primaryCompletion": { "date": "2030-12", "type": "ESTIMATED" }, "enrollment": { "count": 90, "type": "ESTIMATED" }, "primaryOutcomes": [ { "measure": "Oswestry Disability Index", "description": "The primary outcome variable is change in Oswestry Disability index (ODI) from baseline (preoperative) to the 6-month follow-up. ODI is a back specific index measuring disability due to back pain. It is the recommended instrument for studies concerning low back problems. An index from 0-100 is calculated. An ODI of 0-20 indicate minimal disability, 21-40; moderate disability, 41-60; severe disability, 61-80; severely crippled, 81-100; bed-bound.", "timeFrame": "From baseline to the 6-month follow-up." } ], "firstPost": { "date": "2024-11-29", "type": "ACTUAL" }, "new_to_tracker": true } ], "trial_change_limit": "Local prior snapshot stores status labels but not full historical JSON or posted-results fields. Compare status labels to that snapshot; use live last-update/results-first-post dates for window claims. Do not infer enrollment or endpoint changes without historical records.", "independent_audit_completed": false, "local_validation": { "changed_markdown": 11, "bibliography_unique": 358, "tracked_nct": 49, "new_line_live_pmids": 12, "new_line_live_nct": 16, "errors": [] } }