{ "condition": "copd", "sweep_date": "2026-10-27", "author_engine": "Codex", "window": { "from": "2026-08-28", "to": "2026-10-27", "pubmed_field": "[dp]" }, "pubmed": { "queries": { "diagnosis": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (spirometry[tiab] OR diagnosis[tiab] OR \"case finding\"[tiab] OR underdiagnosis[tiab] OR \"lower limit of normal\"[tiab] OR \"pre-COPD\"[tiab] OR PRISm[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"spirometry\"[Title/Abstract] OR \"diagnosis\"[Title/Abstract] OR \"case finding\"[Title/Abstract] OR \"underdiagnosis\"[Title/Abstract] OR \"lower limit of normal\"[Title/Abstract] OR \"pre-COPD\"[Title/Abstract] OR \"PRISm\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 237, "ids": [ "42933872", "42933687", "42930582", "42928917", "42928880", "42926887", "42925274", "42924621", "42923669", "42923616", "42922499", "42922284", "42920925", "42920844", "42915453", "42914685", "42911953", "42911886", "42908796", "42907946", "42907263", "42907121", "42904526", "42904223", "42903829", "42903157", "42902645", "42901581", "42901244", "42900403", "42899456", "42899177", "42894652", "42894311", "42893318", "42892376", "42891961", "42891304", "42890797", "42889261", "42889156", "42886159", "42883438", "42882316", "42882164", "42881837", "42881689", "42881572", "42879152", "42878096", "42878026", "42877096", "42876310", "42871931", "42867256", "42866360", "42866238", "42865811", "42865211", "42864666", "42860238", "42857998", "42857644", "42857362", "42856556", "42844875", "42844490", "42843929", "42843053", "42840673", "42840012", "42839305", "42836949", "42833477", "42833476", "42832978", "42831966", "42831112", "42830888", "42829719", "42829597", "42829540", "42829170", "42826728", "42826512", "42825346", "42820089", "42823318", "42822498", "42818452", "42818151", "42817919", "42816439", "42815744", "42814120", "42813636", "42811567", "42809997", "42807840", "42807362", "42807354", "42807062", "42806974", "42805994", "42802932", "42801453", "42796426", "42796015", "42793803", "42793493", "42792707", "42790974", "42789746", "42782486", "42781194", "42779315", "42778201", "42776696", "42776695", "42773542", "42769809", "42769223", "42766492", "42766486", "42765005", "42764402", "42763198", "42755665", "42753287", "42749349", "42744412", "42744204", "42743534", "42743084", "42743080", "42739775", "42739212", "42736665", "42735858", "42731041", "42729998", "42728690", "32809745", "42726374", "42725037", "42724634", "42724618", "42723543", "42719613", "42718945", "42718934", "42717227", "42713373", "42707541", "42707232", "42706206", "42701775", "42701522", "42701440", "42701415", "42700427", "42699859", "42699828", "42699708", "42697205", "42687556", "42683023", "42682784", "42681260", "42679471", "42675482", "42674271", "42668731", "42665305", "42665061", "42663089", "42643884", "42636988", "42635956", "42629534", "42625685", "42624223", "42610689", "42607740", "42551716", "42551713", "42562238", "42537791", "42501604", "42491235", "42480573", "42476498", "42476425", "42474633", "42470418", "42455020", "42447589", "42442716", "42435914", "42435531", "42426951", "42425178", "42421199", "42417387", "42409225", "42392279", "42391100", "42389860", "42362121", "42331984", "42330343", "42314775", "42288396", "42276842", "42251912", "42242757", "42233594", "42184284", "42171694", "42142305", "42140348", "42128767", "42117467", "42089967", "42083403", "42070637", "42034331", "42024959", "42024580", "41985297", "41979097", "41873608", "41328889", "40698426", "40491388", "40491387", "40372314" ] }, "epidemiology": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (prevalence[tiab] OR incidence[tiab] OR mortality[tiab] OR burden[tiab] OR \"Global Burden\"[tiab] OR DALY*[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"prevalence\"[Title/Abstract] OR \"incidence\"[Title/Abstract] OR \"mortality\"[Title/Abstract] OR \"burden\"[Title/Abstract] OR \"Global Burden\"[Title/Abstract] OR \"daly*\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 462, "ids": [ "42933872", "42933687", "42933164", "42931406", "42931370", "42930048", "42929037", "42924737", "42924627", "42924625", "42924621", "42923616", "42922950", "42922607", "42921797", "42921587", "42920844", "42920666", "42920623", "42920262", "42914555", "42913936", "42911886", "42910254", "42908796", "42908640", "42908534", "42907946", "42907700", "42906940", "42906349", "42905901", "42904136", "42903829", "42903722", "42903200", "42903157", "42902830", "42902645", "42901572", "42901244", "42900457", "42899181", "42899177", "42898932", "42898870", "42898698", "42898520", "42897575", "42897393", "42896716", "42894311", "42893247", "42891930", "42891734", "42891288", "42891260", "42890797", "42890759", "42890526", "42889826", "42889261", "42888584", "42885319", "42884123", "42884046", "42882357", "42882316", "42882235", "42881801", "42881733", "42881689", "42881075", "42879152", "42878096", "42877334", "42877096", "42876310", "42875068", "42874870", "42872502", "42872100", "42871931", "42871153", "42871150", "42871116", "42867073", "42866737", "42866732", "42866550", "42866238", "42866198", "42865918", "42865211", "42864666", "42863936", "42861947", "42861302", "42860278", "42859980", "42859794", "42857998", "42857754", "42857644", "42857213", "42856556", "42855085", "42852906", "42852893", "42852718", "42852569", "42847754", "42845735", "42845158", "42844875", "42844490", "42843053", "42841936", "42841793", "42841174", "42839647", "42839285", "42838806", "42838481", "42838239", "42836949", "42836146", "42835217", "42833910", "42833548", "42832388", "42831475", "42831112", "42831088", "42831046", "42830285", "42829597", "42827170", "42826728", "42826512", "42826321", "42826271", "42825346", "42825262", "42818353", "42818151", "42816626", "42816454", "42816088", "42815330", "42814120", "42813308", "42812767", "42809997", "42809297", "42807842", "42807613", "42807417", "42807062", "42807056", "42805994", "42805833", "42805332", "42804408", "42804204", "42803962", "42803494", "42802926", "42802746", "42801453", "42801175", "42798561", "42798039", "42796426", "42796263", "42793654", "42793634", "42793525", "42793507", "42793458", "42791602", "42791548", "42790974", "42790395", "42790179", "42787135", "42786423", "42786303", "42782989", "42782493", "42781194", "42779858", "42778201", "42777916", "42776697", "42776696", "42776136", "42776133", "42773542", "42773460", "42773082", "42772467", "42770007", "42769223", "42769106", "42769032", "42768888", "42767802", "42767479", "42765005", "42763704", "42763198", "42763192", "42763189", "42761905", "42760692", "42760677", "42760212", "42760129", "42759155", "42758741", "42758674", "42758666", "42758197", "42756486", "42754632", "42754519", "42753772", "42753287", "42751152", "42750629", "42750609", "42750455", "42749449", "42749435", "42749349", "42749280", "42748386", "42746804", "42746077", "42744380", "42744204", "42744008", "42743135", "42741722", "42741470", "42741206", "42739813", "42739805", "42739775", "42739212", "42738369", "42737593", "42736748", "42736665", "42734898", "42734176", "42734163", "42731041", "42730947", "42729998", "42728228", "42727532", "42726374", "42726372", "42726063", "42725278", "42724737", "42724634", "42724407", "42724406", "42721777", "42719712", "42719613", "42719105", "42717348", "42717227", "42717150", "42716782", "42716688", "42714194", "42711111", "42710603", "42710513", "42709430", "42707933", "42707541", "42707527", "42706206", "42705524", "42705504", "42705490", "42705339", "42704890", "42701775", "42701440", "42701415", "42700427", "42699708", "42699305", "42699267", "42696184", "42695440", "42693471", "42692185", "42690965", "42690694", "42688853", "42688733", "42684648", "42683919", "42683441", "42683023", "42682881", "42682871", "42681260", "42680506", "42679174", "42676072", "42675764", "42674271", "42671408", "42667442", "42665355", "42665305", "42665061", "42663928", "42663560", "42663079", "42659031", "42641996", "42641443", "42636993", "42636988", "42635956", "42629534", "42607740", "42604085", "42596503", "42585856", "42584416", "42551713", "42562238", "42561872", "42548201", "42547963", "42544014", "42543031", "42537819", "42537791", "42532360", "42527215", "42526604", "42519111", "42509090", "42508518", "42501604", "42500855", "42492752", "42489718", "42486556", "42480412", "42476498", "42476425", "42474633", "42473419", "42468857", "42460992", "42454974", "42447589", "42447588", "42436658", "42435914", "42435531", "42431469", "42426384", "42425178", "42418962", "42413849", "42403302", "42390593", "42362121", "42337860", "42333497", "42331984", "42330343", "42322795", "42320603", "42315602", "42314183", "42301762", "42289268", "42288396", "42283140", "42281286", "42259118", "42249531", "42244188", "42242757", "42242527", "42240851", "42229232", "42217822", "42189148", "42183930", "42177966", "42177745", "42175599", "42174347", "42173710", "42171694", "42162858", "42159384", "42153327", "42143944", "42142305", "42128769", "42119880", "42119758", "42097456", "42095587", "42085928", "42083403", "42070637", "42069131", "42068691", "42033021", "42026000", "42024580", "41986862", "41986203", "41985297", "41963244", "41950377", "41949785", "41937238", "41896109", "41873608", "41873195", "41804821", "41758011", "41755801", "41738286", "41734305", "41733233", "41677852", "41661079", "41649293", "41644135", "41527261", "41494933", "41490324", "41328889", "40891814", "40832980", "40698436", "40586677", "40549596", "40491388", "40491387", "40390589", "42846888" ] }, "small_airway_emphysema": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"small airway*\"[tiab] OR \"parametric response\"[tiab] OR \"terminal bronchiole*\"[tiab] OR \"mucus plug*\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"small airway*\"[Title/Abstract] OR \"parametric response\"[Title/Abstract] OR \"terminal bronchiole*\"[Title/Abstract] OR \"mucus plug*\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 46, "ids": [ "42922284", "42920975", "42914685", "42903834", "42888276", "42883438", "42881572", "42864666", "42838277", "42814120", "42807081", "42805317", "42802932", "42789746", "42788667", "42778201", "42776695", "42770821", "42769032", "42766492", "42764410", "42762984", "42758674", "42753287", "42746077", "42719853", "42707927", "42701782", "42665061", "42635956", "42612521", "42607740", "42562589", "42480574", "42480573", "42473419", "42458821", "42447589", "42330343", "42330336", "42276842", "42242040", "42184284", "42183930", "42097456", "40372314" ] }, "inflammation": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (eosinophil*[tiab] OR \"type 2\"[tiab] OR neutrophil*[tiab] OR microbiome[tiab] OR endotype*[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"eosinophil*\"[Title/Abstract] OR \"type 2\"[Title/Abstract] OR \"neutrophil*\"[Title/Abstract] OR \"microbiome\"[Title/Abstract] OR \"endotype*\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 159, "ids": [ "42933872", "42933817", "42933687", "42932922", "42930581", "42930487", "42930050", "42930048", "42928917", "42928777", "42923669", "42921797", "42921543", "42921042", "42920623", "42907946", "42906940", "42906349", "42904223", "42901244", "42898768", "42894652", "42889372", "42882468", "42882316", "42882047", "42880940", "42878116", "42877096", "42876713", "42872211", "42871116", "42869731", "42866550", "42866360", "42864764", "42860278", "42859980", "42858866", "42856088", "42855724", "42845784", "42843847", "42839826", "42839285", "42838277", "42834959", "42831943", "42831088", "42831046", "42830888", "42829170", "42826271", "42825262", "42820095", "42821775", "42821483", "42816626", "42813234", "42812739", "42808452", "42806973", "42805959", "42805332", "42805097", "42803733", "42802784", "42801161", "42796263", "42795352", "42795312", "42793803", "42792707", "42785630", "42782552", "42781194", "42779896", "42778035", "42776697", "42773542", "42770007", "42769106", "42769092", "42769032", "42767594", "42761905", "42760939", "42760677", "42760212", "42756486", "42751152", "42750861", "42750333", "42750319", "42747294", "42747060", "42741717", "42734898", "42727368", "42726765", "42724737", "42716515", "42708515", "42707303", "42701775", "42700427", "42699828", "42699792", "42697279", "42685797", "42683175", "42682881", "42682871", "42682833", "42674271", "42667442", "42665061", "42656167", "42635956", "42593569", "42584416", "42551716", "42562589", "42556439", "42543031", "42521255", "42519111", "42509090", "42471095", "42470888", "42447589", "42419728", "42413831", "42403302", "42379526", "42374013", "42372954", "42342518", "42337920", "42337860", "42337097", "42330336", "42314183", "42265988", "42259946", "42252066", "42242757", "42153327", "42148905", "42148875", "42115004", "42089304", "42067210", "41919449", "41873195", "41629169", "41621870", "40832980", "40698426" ] }, "genetics_aatd": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"alpha-1 antitrypsin\"[tiab] OR \"alpha1-antitrypsin\"[tiab] OR AATD[tiab] OR SERPINA1[tiab] OR GWAS[tiab] OR \"polygenic\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"alpha-1 antitrypsin\"[Title/Abstract] OR \"alpha1-antitrypsin\"[Title/Abstract] OR \"AATD\"[Title/Abstract] OR \"SERPINA1\"[Title/Abstract] OR \"GWAS\"[Title/Abstract] OR \"polygenic\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 22, "ids": [ "42928917", "42908640", "42879152", "42850118", "42841174", "42823318", "42806886", "42805959", "42779858", "42774110", "42758741", "42751338", "42750455", "42745457", "42744204", "42741722", "42713628", "42682829", "42610689", "42534701", "42378266", "41804821" ] }, "exposures": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (smoking[tiab] OR \"e-cigarette*\"[tiab] OR biomass[tiab] OR \"air pollution\"[tiab] OR occupational[tiab] OR \"smoking cessation\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"smoking\"[Title/Abstract] OR \"e cigarette*\"[Title/Abstract] OR \"biomass\"[Title/Abstract] OR \"air pollution\"[Title/Abstract] OR \"occupational\"[Title/Abstract] OR \"smoking cessation\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 200, "ids": [ "42933872", "42930050", "42923669", "42922284", "42921783", "42914145", "42913275", "42908640", "42907263", "42906829", "42905895", "42904223", "42903834", "42902645", "42901572", "42899790", "42898932", "42898894", "42898698", "42897393", "42896085", "42890857", "42890759", "42889849", "42889156", "42888276", "42884046", "42882357", "42877639", "42876816", "42871509", "42871085", "42867256", "42866732", "42866360", "42865211", "42859980", "42857754", "42852903", "42852468", "42844875", "42841174", "42840506", "42838239", "42831475", "42830888", "42829729", "42829540", "42828082", "42827947", "42826728", "42826321", "42825346", "42825262", "42820089", "42818151", "42817919", "42816088", "42815655", "42814476", "42813636", "42807056", "42806974", "42805834", "42805833", "42803733", "42801550", "42796426", "42795846", "42795312", "42793634", "42792707", "42790974", "42788667", "42782493", "42779858", "42778969", "42778201", "42776696", "42776041", "42775283", "42774110", "42773907", "42773542", "42773082", "42771472", "42771356", "42769220", "42769106", "42763198", "42763192", "42763189", "42761905", "42761333", "42760692", "42760129", "42758741", "42756486", "42754610", "42754519", "42753772", "42753436", "42753287", "42751338", "42750861", "42750629", "42750455", "42748386", "42746077", "42744380", "42744204", "42743084", "42743080", "42742863", "42736665", "42735858", "42734163", "42733807", "42731273", "42729998", "42719105", "42717348", "42716782", "42714194", "42713935", "42712018", "42709430", "42709260", "42707541", "42705490", "42702300", "42701440", "42701415", "42699828", "42699792", "42699267", "42698240", "42698073", "42697437", "42697205", "42695739", "42687556", "42683441", "42682881", "42682784", "42679471", "42675482", "42674270", "42665724", "42665061", "42663928", "42659031", "42641996", "42627631", "42625685", "42584416", "42580260", "42551713", "42537819", "42526604", "42501604", "42485676", "42480573", "42476425", "42447588", "42435531", "42435486", "42413849", "42386154", "42342518", "42315602", "42310036", "42302895", "42276842", "42265244", "42244188", "42242757", "42240707", "42229232", "42217822", "42205013", "42175599", "42162858", "42148905", "42148875", "42142305", "42132246", "42128769", "42119880", "42085928", "42067210", "42048924", "42034331", "42033021", "41963244", "41896109", "41804821", "41490324", "40832980", "42846888" ] }, "inhaled_therapy": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (LAMA[tiab] OR LABA[tiab] OR \"inhaled corticosteroid*\"[tiab] OR \"triple therapy\"[tiab] OR budesonide[tiab] OR fluticasone[tiab] OR tiotropium[tiab] OR ensifentrine[tiab] OR inhaler*[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"LAMA\"[Title/Abstract] OR \"LABA\"[Title/Abstract] OR \"inhaled corticosteroid*\"[Title/Abstract] OR \"triple therapy\"[Title/Abstract] OR \"budesonide\"[Title/Abstract] OR \"fluticasone\"[Title/Abstract] OR \"tiotropium\"[Title/Abstract] OR \"ensifentrine\"[Title/Abstract] OR \"inhaler*\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 89, "ids": [ "42933872", "42930048", "42928917", "42914145", "42911714", "42908195", "42907700", "42905901", "42904140", "42903722", "42899177", "42889372", "42887614", "42887045", "42882183", "42876310", "42875068", "42871116", "42869434", "42865803", "42864756", "42861035", "42848547", "42845881", "42839305", "42836213", "42833477", "42833476", "42831088", "42831046", "42822709", "42819554", "42819502", "42809997", "42804209", "42803733", "42799591", "42798260", "42798039", "42796263", "42795312", "42791624", "42789344", "42789236", "42782552", "42778969", "42775283", "42773542", "42766845", "42761905", "42761771", "42756486", "42743135", "42742863", "42741955", "42734778", "42726372", "42717150", "42699828", "42699305", "42693577", "42684139", "42683865", "42682881", "42675764", "42667442", "42660606", "42629534", "42551716", "42549852", "42521643", "42519111", "42509090", "42492788", "42480626", "42391132", "42320603", "42289268", "42281286", "42205013", "42166818", "42159704", "42150017", "42128769", "42085256", "41990594", "41985297", "41979103", "40698436" ] }, "exacerbations": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (exacerbation*[tiab] OR AECOPD[tiab] OR readmission*[tiab] OR \"noninvasive ventilation\"[tiab] OR \"non-invasive ventilation\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"exacerbation*\"[Title/Abstract] OR \"AECOPD\"[Title/Abstract] OR \"readmission*\"[Title/Abstract] OR \"noninvasive ventilation\"[Title/Abstract] OR \"non-invasive ventilation\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 329, "ids": [ "42933872", "42933864", "42933817", "42933687", "42933164", "42930048", "42928917", "42928902", "42928880", "42928777", "42924627", "42922130", "42921797", "42921783", "42921543", "42921241", "42920623", "42919454", "42914685", "42914145", "42914006", "42913274", "42912560", "42911886", "42908195", "42907946", "42907700", "42906940", "42906829", "42906587", "42906271", "42905901", "42904810", "42904526", "42904223", "42904141", "42903200", "42902830", "42902768", "42901808", "42901572", "42901278", "42900403", "42899181", "42898894", "42898293", "42896794", "42894311", "42893309", "42893150", "42893075", "42892215", "42890797", "42890526", "42885566", "42885332", "42885319", "42882316", "42882183", "42881801", "42880459", "42878658", "42877358", "42876922", "42876310", "42875068", "42874915", "42874036", "42872533", "42872211", "42872100", "42871890", "42871085", "42869823", "42869434", "42866737", "42866653", "42866350", "42865926", "42864756", "42864666", "42863936", "42860278", "42859980", "42859312", "42852899", "42852718", "42850639", "42846262", "42845735", "42843847", "42842938", "42841793", "42841509", "42841174", "42840420", "42839285", "42838838", "42833910", "42833477", "42831088", "42831046", "42830888", "42829719", "42828396", "42827170", "42826271", "42823634", "42820089", "42821775", "42818656", "42816454", "42813308", "42809997", "42807843", "42807842", "42805834", "42805097", "42802784", "42802746", "42801650", "42801453", "42800650", "42796263", "42795536", "42793458", "42790395", "42789746", "42786423", "42786303", "42785630", "42783486", "42782552", "42782493", "42779896", "42779315", "42776698", "42776605", "42776308", "42776026", "42774738", "42774150", "42773542", "42773460", "42772899", "42772467", "42769451", "42768888", "42768446", "42766845", "42766492", "42762984", "42761937", "42761905", "42761771", "42760649", "42760212", "42760128", "42759155", "42758741", "42758674", "42756486", "42754632", "42754519", "42753287", "42752271", "42751184", "42749468", "42747060", "42746368", "42745957", "42745881", "42742863", "42742400", "42742120", "42741955", "42741717", "42734898", "42734176", "42731630", "42730598", "32809745", "42728228", "42727532", "42727368", "42726374", "42725037", "42724737", "42724423", "42724335", "42721477", "42716617", "42716606", "42712018", "42708515", "42707933", "42707515", "42706206", "42705339", "42703559", "42701865", "42701440", "42701415", "42701340", "42700427", "42699828", "42693471", "42692274", "42690694", "42688733", "42687350", "42685939", "42683865", "42683431", "42683176", "42682881", "42682833", "42675764", "42674270", "42670655", "42667442", "42660530", "42659914", "42647572", "42642859", "42636993", "42636988", "42635956", "42629534", "42624223", "42622415", "42616679", "42608564", "42608563", "42607740", "42600284", "42593569", "42585856", "42551716", "42562589", "42557610", "42552543", "42549852", "42545984", "42538277", "42528123", "42521643", "42521255", "42519111", "42509090", "42508762", "42492788", "42486571", "42486559", "42486556", "42480412", "42475870", "42473419", "42471816", "42460992", "42447589", "42431469", "42426384", "42419728", "42403302", "42392279", "42390593", "42386154", "42386008", "42379526", "42375681", "42372954", "42363406", "42363405", "42362120", "42348945", "42342518", "42337860", "42337097", "42336667", "42330343", "42322795", "42320603", "42314775", "42314183", "42298202", "42289268", "42283140", "42281286", "42275917", "42265988", "42262219", "42243431", "42242757", "42240707", "42234545", "42190503", "42183930", "42173710", "42153327", "42148905", "42148875", "42134570", "42128769", "42106260", "42097456", "42085928", "42069131", "42068691", "42047182", "42033021", "42029388", "42026000", "41986203", "41985297", "41950377", "41937238", "41919449", "41873195", "41758011", "41734305", "41733233", "41677852", "41644135", "41629169", "41512102", "41490324", "41328889", "40390589" ] }, "rehabilitation": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"pulmonary rehabilitation\"[tiab] OR telerehabilitation[tiab] OR \"self-management\"[tiab] OR exercise[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"pulmonary rehabilitation\"[Title/Abstract] OR \"telerehabilitation\"[Title/Abstract] OR \"self-management\"[Title/Abstract] OR \"exercise\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 129, "ids": [ "42933872", "42932895", "42930052", "42930050", "42928679", "42924621", "42922284", "42914006", "42913274", "42913179", "42910776", "42910133", "42906271", "42904147", "42903829", "42899053", "42898520", "42897042", "42896716", "42895273", "42891961", "42891930", "42888100", "42885566", "42885319", "42882183", "42881075", "42877639", "42872922", "42872488", "42871624", "42869823", "42864666", "42863686", "42861835", "42859980", "42859794", "42858305", "42857213", "42855085", "42855003", "42852888", "42845158", "42841793", "42840673", "42839305", "42838838", "42838806", "42836146", "42834905", "42828082", "42814476", "42810416", "42809523", "42808452", "42807843", "42807718", "42798561", "42795810", "42795309", "42793634", "42791602", "42790974", "42789344", "42786795", "42786546", "42786523", "42774738", "42772467", "42767802", "42766845", "42761905", "42761333", "42760127", "42758197", "42755665", "42749900", "42733827", "42725037", "42724538", "42724423", "42724407", "42723543", "42717348", "42716547", "42707527", "42707232", "42705339", "42703360", "42701779", "42695739", "42695215", "42679174", "42666801", "42629000", "42622334", "42617066", "42616316", "42586168", "42539704", "42509090", "42508518", "42485676", "42480412", "42473418", "42468857", "42447588", "42413831", "42409226", "42409225", "42397015", "42392279", "42386008", "42362458", "42342518", "42314775", "42276842", "42275921", "42259720", "42248680", "42150017", "42143500", "42053497", "42047182", "41949785", "41843815", "41581205", "40372314", "39255457" ] }, "oxygen_niv": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"long-term oxygen\"[tiab] OR \"oxygen therapy\"[tiab] OR \"home noninvasive\"[tiab] OR \"home non-invasive\"[tiab] OR \"high-flow\"[tiab] OR palliative[tiab] OR breathlessness[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"long-term oxygen\"[Title/Abstract] OR \"oxygen therapy\"[Title/Abstract] OR \"home noninvasive\"[Title/Abstract] OR \"home non-invasive\"[Title/Abstract] OR \"high-flow\"[Title/Abstract] OR \"palliative\"[Title/Abstract] OR \"breathlessness\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 76, "ids": [ "42933872", "42931911", "42921241", "42914685", "42913274", "42912560", "42909953", "42907946", "42906940", "42904141", "42899053", "42898520", "42897575", "42892394", "42892215", "42889784", "42888100", "42880459", "42872922", "42871890", "42871153", "42859980", "42859312", "42857213", "42852893", "42845158", "42842938", "42841174", "42833910", "42831112", "42823634", "42813981", "42813308", "42809997", "42807081", "42802746", "42796426", "42793525", "42783486", "42782261", "42775276", "42769106", "42767802", "42761905", "42760127", "42755665", "42749468", "42739212", "42728228", "42726765", "42713935", "42705339", "42703360", "42699708", "42685648", "42663560", "42660530", "42586530", "42537819", "42491235", "42486559", "42480412", "42433298", "42413924", "42397015", "42390593", "42152177", "42106260", "42047182", "41986203", "41985297", "41949785", "41581205", "41512102", "40891814", "40586677" ] }, "procedures": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"endobronchial valve*\"[tiab] OR \"lung volume reduction\"[tiab] OR \"lung transplant*\"[tiab] OR bronchoscopic[tiab] OR bullectomy[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"endobronchial valve*\"[Title/Abstract] OR \"lung volume reduction\"[Title/Abstract] OR \"lung transplant*\"[Title/Abstract] OR \"bronchoscopic\"[Title/Abstract] OR \"bullectomy\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 38, "ids": [ "42933872", "42920666", "42914555", "42909126", "42900658", "42891961", "42886159", "42872488", "42872474", "42859980", "42854034", "42852569", "42850067", "42839647", "42829651", "42816439", "42809997", "42781194", "42772814", "42769032", "42751341", "42731041", "42724737", "42724407", "42724310", "42705339", "42701340", "42700980", "42688853", "42612521", "42544014", "42509090", "42500855", "42468857", "42447589", "42259720", "42248680", "41856570" ] }, "comorbidity": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (cardiovascular[tiab] OR cardiopulmonary[tiab] OR \"heart failure\"[tiab] OR osteoporosis[tiab] OR frailty[tiab] OR depression[tiab] OR anxiety[tiab] OR \"lung cancer\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"cardiovascular\"[Title/Abstract] OR \"cardiopulmonary\"[Title/Abstract] OR \"heart failure\"[Title/Abstract] OR \"osteoporosis\"[Title/Abstract] OR \"frailty\"[Title/Abstract] OR \"depression\"[Title/Abstract] OR \"anxiety\"[Title/Abstract] OR \"lung cancer\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 323, "ids": [ "42933872", "42933164", "42932895", "42931699", "42931370", "42930048", "42928917", "42928679", "42926887", "42924625", "42924621", "42922499", "42921783", "42921587", "42921241", "42921196", "42921042", "42920925", "42920262", "42914006", "42912560", "42911634", "42910776", "42910254", "42909953", "42908534", "42907974", "42906940", "42906349", "42904147", "42902830", "42902645", "42901278", "42901244", "42899053", "42898932", "42898293", "42897575", "42894800", "42893318", "42893150", "42892376", "42892215", "42891961", "42891288", "42891260", "42890857", "42890759", "42888065", "42885566", "42885319", "42882357", "42882047", "42881733", "42881689", "42881582", "42876958", "42874870", "42872502", "42871931", "42871509", "42869731", "42867257", "42867073", "42866737", "42866360", "42866350", "42866198", "42865926", "42865211", "42864955", "42863661", "42861302", "42860278", "42859980", "42858305", "42857998", "42857754", "42856556", "42855085", "42852906", "42852718", "42852569", "42850115", "42847754", "42846023", "42845158", "42844490", "42843657", "42838838", "42838239", "42836949", "42835775", "42834905", "42833208", "42832530", "42831966", "42830122", "42829729", "42829622", "42828082", "42827947", "42826728", "42823634", "42822709", "42820327", "42816454", "42816397", "42813308", "42813033", "42812767", "42807718", "42805994", "42804408", "42802746", "42801175", "42800650", "42798039", "42796015", "42793654", "42793525", "42793507", "42793458", "42792939", "42792707", "42792180", "42791548", "42787135", "42786423", "42785630", "42783486", "42778207", "42778035", "42776715", "42776697", "42776136", "42775341", "42775276", "42774579", "42774150", "42773542", "42773082", "42772467", "42772110", "42770131", "42770058", "42769451", "42769106", "42769092", "42767594", "42767479", "42767436", "42765005", "42764402", "42763189", "42761879", "42761333", "42761171", "42760939", "42760692", "42760677", "42760209", "42759155", "42757029", "42754632", "42754610", "42754519", "42753436", "42750629", "42750455", "42749468", "42749449", "42746804", "42746668", "42744412", "42744380", "42744008", "42743135", "42743080", "42739813", "42738369", "42736383", "42735858", "42734176", "42731273", "42730947", "42729998", "32809745", "42728228", "42726063", "42725278", "42725037", "42724538", "42724406", "42724335", "42724310", "42722804", "42719713", "42717348", "42716782", "42716547", "42714263", "42714194", "42713628", "42711268", "42710513", "42709430", "42707527", "42707232", "42705915", "42704083", "42703559", "42702300", "42701865", "42701522", "42701440", "42701415", "42699836", "42699792", "42699698", "42696184", "42695739", "42695440", "42695215", "42690965", "42685648", "42685493", "42684648", "42683919", "42683697", "42683176", "42681260", "42679471", "42676072", "42675482", "42674267", "42671408", "42668731", "42667245", "32644719", "42665305", "42663928", "42663560", "42663289", "42663089", "42659031", "42643884", "42641996", "42629534", "42622334", "42604085", "42585856", "42561872", "42556439", "42548201", "42544014", "42543402", "42537819", "42537791", "42526604", "42519111", "42508762", "42508518", "42501604", "42476425", "42474633", "42470418", "42458821", "42448932", "42447589", "42435531", "42431469", "42426384", "42425178", "42413924", "42409226", "42399449", "42392279", "42362120", "42342518", "42320603", "42315602", "42310036", "42302895", "42301762", "42276842", "42276273", "42275921", "42275917", "42259946", "42248036", "42242527", "42217822", "42208925", "42189148", "42177966", "42177745", "42171694", "42162858", "42159704", "42159384", "42157377", "42143944", "42143500", "42140348", "42089967", "42070637", "42068691", "42029857", "42029388", "41950377", "41949785", "41802233", "41795868", "41733233", "41677852", "41649293", "41527261", "41504608", "41501304", "41490324", "41328889", "39255457" ] }, "guidelines": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (guideline*[tiab] OR GOLD[tiab] OR \"consensus statement\"[tiab] OR \"position statement\"[tiab] OR \"practice guideline\"[pt]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"guideline*\"[Title/Abstract] OR \"GOLD\"[Title/Abstract] OR \"consensus statement\"[Title/Abstract] OR \"position statement\"[Title/Abstract] OR \"practice guideline\"[Publication Type]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 144, "ids": [ "42933872", "42930052", "42928880", "42925274", "42924737", "42924627", "42924621", "42923616", "42921783", "42920925", "42920844", "42914006", "42913936", "42913179", "42912560", "42911953", "42910776", "42909126", "42907946", "42906587", "42904526", "42904141", "42902645", "42899456", "42898293", "42897042", "42896716", "42896235", "42889156", "42888276", "42885566", "42882316", "42882183", "42881689", "42879152", "42878096", "42876713", "42875068", "42867256", "42866550", "42866177", "42865811", "42857213", "42855085", "42852888", "42841509", "42840673", "42839647", "42839305", "42834905", "42833476", "42831112", "42826512", "42817919", "42814120", "42813636", "42809297", "42807843", "42807842", "42802746", "42801550", "42801453", "42798561", "42796426", "42793525", "42792939", "42790179", "42779315", "42778201", "42776696", "42773542", "42771356", "42768888", "42766492", "42761771", "42759155", "42756486", "42749468", "42746368", "42746077", "42745881", "42743135", "42741955", "42741470", "42736665", "42736383", "42735858", "42725037", "42724310", "42723543", "42718945", "42717227", "42713935", "42712018", "42710513", "42707232", "42706206", "42705044", "42701782", "42701775", "42701440", "42687556", "42684139", "42675764", "42674270", "42667442", "42663089", "42659914", "42624223", "42616679", "42600392", "42552543", "42549852", "42521643", "42519111", "42509090", "42508762", "42492752", "42454974", "42447589", "42425178", "42418962", "42417382", "42402212", "42349048", "42322795", "42315602", "42297156", "42275917", "42171694", "42150017", "42143944", "42128767", "42119498", "42097456", "42089967", "42083403", "42029388", "41986203", "41985297", "41979097", "41661079", "41501304", "41421865" ] }, "biomarkers_imaging": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (biomarker*[tiab] OR \"computed tomography\"[tiab] OR \"CT\"[tiab] OR MRI[tiab] OR \"artificial intelligence\"[tiab] OR \"deep learning\"[tiab] OR fibrinogen[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"biomarker*\"[Title/Abstract] OR \"computed tomography\"[Title/Abstract] OR \"CT\"[Title/Abstract] OR \"MRI\"[Title/Abstract] OR \"artificial intelligence\"[Title/Abstract] OR \"deep learning\"[Title/Abstract] OR \"fibrinogen\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 288, "ids": [ "42933872", "42932007", "42930052", "42930050", "42924621", "42923041", "42922607", "42920925", "42915453", "42914685", "42913936", "42913273", "42911634", "42909126", "42908796", "42908534", "42907946", "42906940", "42904141", "42903829", "42902830", "42899181", "42899114", "42898293", "42895273", "42891961", "42891304", "42889784", "42889372", "42889156", "42888276", "42882357", "42882316", "42882287", "42882235", "42882001", "42881572", "42880940", "42878026", "42877802", "42877618", "42877096", "42875772", "42874915", "42872100", "42871890", "42871624", "42871085", "42866550", "42866360", "42866238", "42866198", "42865805", "42864764", "42861343", "42861035", "42857362", "42852906", "42851569", "42846902", "42846023", "42844875", "42843929", "42843845", "42843053", "42842938", "42841936", "42840012", "42838239", "42836120", "42835819", "42832530", "42831966", "42831943", "42831112", "42831088", "42831046", "42830888", "42830122", "42829729", "42829719", "42829597", "42829540", "42827170", "42826271", "42825743", "42823318", "42822498", "42818452", "42816439", "42815744", "42814120", "42813636", "42813033", "42811567", "42809997", "42808452", "42807613", "42807081", "42807062", "42806973", "42805332", "42805317", "42803733", "42801161", "42799591", "42795312", "42795304", "42793803", "42792707", "42792180", "42791602", "42789746", "42789236", "42788667", "42787135", "42785424", "42784862", "42783763", "42782989", "42782552", "42782486", "42778969", "42778254", "42778207", "42778201", "42776697", "42776308", "42774738", "42774579", "42773542", "42770821", "42769220", "42769092", "42769032", "42767479", "42766492", "42766486", "42762984", "42762782", "42761879", "42761195", "42761171", "42760692", "42760677", "42760429", "42760212", "42758741", "42758674", "42755665", "42755119", "42753287", "42752271", "42751184", "42750629", "42749435", "42749301", "42746804", "42746668", "42745957", "42744412", "42744380", "42743534", "42743080", "42736665", "42731822", "42729998", "42727532", "42724634", "42724335", "42724310", "42722722", "42720851", "42719613", "42718934", "42717029", "42716782", "42714263", "42713628", "42712996", "42711268", "42709368", "42708636", "42707527", "42707303", "42706206", "42705044", "42703518", "42701782", "42701775", "42701633", "42701522", "42699868", "42699859", "42699836", "42699802", "42697205", "42695583", "42695215", "42694943", "42692097", "42690965", "42690694", "42688733", "42683441", "42683175", "42682945", "42682784", "42679471", "42675482", "42667245", "42665061", "42663289", "42660606", "42643884", "42636993", "42636988", "42635956", "42616679", "42586168", "42562589", "42562238", "42556749", "42552543", "42534701", "42501604", "42492788", "42491235", "42476498", "42470418", "42456832", "42454974", "42447589", "42442716", "42435531", "42427191", "42425178", "42403302", "42401375", "42399449", "42398097", "42392279", "42386008", "42374013", "42372954", "42362120", "42342518", "42337860", "42330343", "42315602", "42314183", "42310036", "42307991", "42288169", "42276842", "42265988", "42259118", "42251912", "42242757", "42242040", "42240707", "42217822", "42209372", "42208731", "42183930", "42177966", "42174347", "42171694", "42167350", "42159704", "42132246", "42126556", "42097456", "42095587", "42089967", "42085213", "42085202", "42083403", "42034331", "42026000", "41979097", "41873195", "41654320", "41527261", "41507659", "41501304", "41421865", "40698426" ] }, "biologics_trials": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (dupilumab[tiab] OR mepolizumab[tiab] OR benralizumab[tiab] OR tezepelumab[tiab] OR itepekimab[tiab] OR tozorakimab[tiab] OR astegolimab[tiab] OR biologic*[tiab] OR \"phase 3\"[tiab] OR \"phase III\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"dupilumab\"[Title/Abstract] OR \"mepolizumab\"[Title/Abstract] OR \"benralizumab\"[Title/Abstract] OR \"tezepelumab\"[Title/Abstract] OR \"itepekimab\"[Title/Abstract] OR \"tozorakimab\"[Title/Abstract] OR \"astegolimab\"[Title/Abstract] OR \"biologic*\"[Title/Abstract] OR \"phase 3\"[Title/Abstract] OR \"phase III\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 128, "ids": [ "42933872", "42931699", "42930487", "42930050", "42928917", "42928777", "42922607", "42913936", "42910254", "42908796", "42906940", "42904223", "42904140", "42891486", "42889372", "42888116", "42882001", "42881801", "42881075", "42878116", "42877618", "42876816", "42874915", "42864764", "42852919", "42852718", "42846262", "42846023", "42845784", "42841793", "42839285", "42838277", "42831112", "42831088", "42831046", "42830888", "42830793", "42822498", "42816454", "42815330", "42809997", "42806973", "42803733", "42802784", "42801161", "42795536", "42795304", "42792707", "42791602", "42790974", "42789236", "42786303", "42785630", "42783763", "42782552", "42779315", "42777916", "42776697", "42774738", "42774579", "42773542", "42770131", "42769451", "42761905", "42758674", "42751184", "42750455", "42750319", "42749449", "42741717", "42725278", "42724737", "42724664", "42716617", "42716547", "42716515", "42713628", "42709275", "42708515", "42699267", "42697279", "42687556", "42686822", "42683175", "42682833", "42675037", "42665061", "42656167", "42635956", "42580260", "42551716", "42562589", "42537791", "42509090", "42508746", "42476498", "42456832", "42447589", "42442716", "42435531", "42403302", "42401321", "42386154", "42381344", "42375681", "42374013", "42372954", "42337920", "42337097", "42330343", "42314183", "42281286", "42265988", "42259118", "42252066", "42242757", "42183930", "42177966", "42153327", "42148905", "42148875", "42128767", "42095587", "42046906", "42029857", "41873195", "41654320", "41621870" ] }, "patient_experience": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (stigma[tiab] OR qualitative[tiab] OR \"patient experience\"[tiab] OR caregiver*[tiab] OR \"quality of life\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"stigma\"[Title/Abstract] OR \"qualitative\"[Title/Abstract] OR \"patient experience\"[Title/Abstract] OR \"caregiver*\"[Title/Abstract] OR \"quality of life\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 125, "ids": [ "42930052", "42930050", "42924625", "42924621", "42922284", "42921587", "42914006", "42913179", "42912560", "42911953", "42910776", "42907700", "42905901", "42903722", "42903133", "42899053", "42897575", "42891961", "42885566", "42885319", "42881582", "42881075", "42877639", "42874870", "42869823", "42867257", "42864666", "42863686", "42859980", "42859794", "42857754", "42855085", "42855003", "42852899", "42849827", "42845158", "42841936", "42841793", "42841174", "42840420", "42832388", "42828082", "42826512", "42826262", "42823634", "42819554", "42814476", "42807842", "42807378", "42802746", "42801175", "42798561", "42796098", "42796015", "42793525", "42782261", "42779164", "42775341", "42775283", "42774150", "42772814", "42770058", "42768446", "42767436", "42766845", "42764252", "42761771", "42761171", "42760429", "42758741", "42749900", "42746668", "42744412", "42743135", "42742863", "42741717", "42733852", "42724538", "42724423", "42724407", "42717425", "42716547", "42713935", "42707232", "42705339", "42705044", "42685648", "42685555", "42683919", "42674270", "42665305", "42663560", "42660606", "42622334", "42616316", "42521830", "42509090", "42480412", "42474633", "42473419", "42468857", "42417387", "42413924", "42403302", "42397015", "42386154", "42337920", "42337097", "42259720", "42183930", "42159384", "42152177", "42150017", "42148905", "42143500", "42140348", "42097456", "42053497", "41986203", "41758011", "41649293", "41581205", "40698436", "40372314", "37161739" ] }, "safety": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (pneumonia[tiab] OR pneumothorax[tiab] OR \"respiratory failure\"[tiab] OR hypercapni*[tiab] OR \"adverse event*\"[tiab] OR \"pulmonary embolism\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"pneumonia\"[Title/Abstract] OR \"pneumothorax\"[Title/Abstract] OR \"respiratory failure\"[Title/Abstract] OR \"hypercapni*\"[Title/Abstract] OR \"adverse event*\"[Title/Abstract] OR \"pulmonary embolism\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 189, "ids": [ "42933872", "42931406", "42930048", "42928902", "42928777", "42924737", "42924621", "42923041", "42921402", "42920623", "42919454", "42915453", "42913275", "42913274", "42913273", "42912560", "42909126", "42908796", "42908195", "42906940", "42905895", "42904141", "42903157", "42902830", "42902768", "42900403", "42898697", "42898293", "42893309", "42893150", "42892376", "42892215", "42889784", "42887614", "42885332", "42882235", "42882183", "42881801", "42876922", "42875772", "42874870", "42874036", "42871931", "42871890", "42871153", "42866732", "42866653", "42866238", "42866198", "42865805", "42864764", "42861035", "42857362", "42854034", "42852906", "42852899", "42852888", "42852569", "42846023", "42845158", "42845064", "42843929", "42840012", "42835775", "42833910", "42830285", "42827170", "42825262", "42818656", "42816397", "42815744", "42813033", "42807843", "42807081", "42804408", "42800755", "42798039", "42796098", "42795846", "42793463", "42793458", "42790395", "42790179", "42788599", "42783486", "42782493", "42781194", "42777916", "42776697", "42775358", "42773082", "42770821", "42769451", "42768888", "42761195", "42760212", "42760127", "42758666", "42758197", "42755119", "42754632", "42751184", "42750609", "42750333", "42749468", "42749349", "42749280", "42739212", "42738369", "42736748", "42736665", "42731630", "32809745", "42728228", "42727532", "42726372", "42726063", "42724748", "42721477", "42719712", "42712996", "42710603", "42708515", "42707303", "42705915", "42701865", "42701340", "42701071", "42699868", "42699836", "42699802", "42698240", "42697205", "42693471", "42688853", "42687350", "42685555", "42667442", "42666801", "32644719", "42660606", "42660530", "42647572", "42586530", "42584416", "42534701", "42528123", "42506991", "42500855", "42491235", "42486571", "42486556", "42480626", "42480573", "42480412", "42468857", "42461694", "42443675", "42418962", "42413924", "42412522", "42362458", "42349048", "42342518", "42314183", "42289268", "42283140", "42259720", "42209372", "42177745", "42143944", "42143500", "42134570", "42128769", "42106260", "42095587", "42069131", "41986203", "41979097", "41963244", "41950377", "41937238", "41919449", "41856570", "41738286", "41629169", "41512102", "41504608", "40586677" ] }, "rcts": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (randomized controlled trial[pt] OR \"randomised\"[ti] OR \"randomized\"[ti]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"randomised\"[Title] OR \"randomized\"[Title]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 57, "ids": [ "42925274", "42914006", "42909953", "42908195", "42904147", "42899053", "42888100", "42887614", "42885332", "42874870", "42869434", "42859312", "42855085", "42852919", "42852906", "42852888", "42832388", "42820089", "42802784", "42767802", "42764252", "42760127", "42758197", "42731630", "42728690", "42717034", "42701865", "42701779", "42693471", "42688853", "42551713", "42521830", "42500855", "42480626", "42475870", "42449486", "42413924", "42409226", "42397015", "42387326", "42379526", "42337097", "42281286", "42265988", "42205013", "42159704", "42159384", "42153327", "42150017", "42148875", "42143500", "41843815", "41263593", "40885217", "40262016", "40067955", "39255457" ] }, "systematic_reviews": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (systematic review[pt] OR meta-analysis[pt] OR \"meta-analysis\"[ti] OR \"systematic review\"[ti]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"systematic review\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"meta-analysis\"[Title] OR \"systematic review\"[Title]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 51, "ids": [ "42930487", "42919454", "42913179", "42910776", "42896085", "42882047", "42876713", "42874904", "42859794", "42855085", "42847754", "42845735", "42842938", "42842052", "42835775", "42834905", "42821775", "42814476", "42810416", "42807843", "42802784", "42800650", "42795309", "42790179", "42761844", "42758197", "42741717", "42741206", "42736665", "42734163", "42730947", "42728228", "42724538", "42724335", "42724310", "42717227", "42716782", "42710513", "42705044", "42622334", "42557610", "42500855", "42349048", "42302895", "42242757", "42097456", "42085928", "42053497", "42029388", "41986203", "41661079" ] }, "top_journals": { "query": "(COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"N Engl J Med\"[jour] OR \"Lancet\"[jour] OR \"JAMA\"[jour] OR \"BMJ\"[jour] OR \"Lancet Respir Med\"[jour] OR \"Am J Respir Crit Care Med\"[jour] OR \"Eur Respir J\"[jour] OR \"Chest\"[jour] OR \"Thorax\"[jour] OR \"Nat Med\"[jour] OR \"JAMA Intern Med\"[jour] OR \"Ann Intern Med\"[jour]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "(\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"N Engl J Med\"[Journal] OR \"Lancet\"[Journal] OR \"JAMA\"[Journal] OR \"BMJ\"[Journal] OR \"Lancet Respir Med\"[Journal] OR \"Am J Respir Crit Care Med\"[Journal] OR \"Eur Respir J\"[Journal] OR \"Chest\"[Journal] OR \"Thorax\"[Journal] OR \"Nat Med\"[Journal] OR \"JAMA Intern Med\"[Journal] OR \"Ann Intern Med\"[Journal]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 76, "ids": [ "42933687", "42901808", "42880940", "42860278", "42850067", "42838277", "42833548", "42829170", "42826512", "42813981", "42790895", "42790893", "42789746", "42788667", "42785424", "42776605", "42776041", "42776026", "42772899", "42768446", "42767594", "42762984", "42760129", "42760128", "42760127", "42753772", "42750319", "42747294", "42717034", "42716782", "42716620", "42716617", "42716606", "42710513", "42709457", "42709451", "42708515", "42660606", 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"42143944", "42143500", "42142305", "42140348", "42134570", "42132246", "42128769", "42128767", "42126556", "42126453", "42119880", "42119777", "42119758", "42119498", "42117467", "42115004", "42106260", "42097456", "42095587", "42091360", "42089967", "42089304", "42085928", "42085256", "42085213", "42085202", "42083403", "42070637", "42069131", "42068691", "42067211", "42067210", "42053497", "42048924", "42047182", "42046906", "42034331", "42033021", "42029857", "42029388", "42026000", "42024959", "42024580", "41990594", "41986862", "41986203", "41985297", "41984640", "41979103", "41979097", "41968744", "41963244", "41950377", "41949785", "41945282", "41937238", "41919449", "41896109", "41873608", "41873195", "41863224", "41856570", "41843815", "41804821", "41802233", "41795868", "41780550", "41758011", "41755801", "41738286", "41734305", "41733233", "41728657", "41709776", "41677852", "41661079", "41654320", "41649293", "41644135", "41639948", "41629169", "41621870", "41581205", "41527261", "41512102", "41507659", "41504608", "41501304", "41495625", "41494933", "41490324", "41421865", "41328889", "41263593", "40891814", "40885217", "40832980", "40698436", "40698426", "40586677", "40549596", "40491388", "40491387", "40390589", "40372314", "42846888", "40262016", "40067955", "39255457", "38362896", "37161739" ] }, "cochrane": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (COPD OR \"chronic obstructive\" OR emphysema OR \"pulmonary rehabilitation\" OR bronchiectasis OR \"alpha-1\") AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"pulmonary disease, chronic obstructive\"[MeSH Terms] OR (\"pulmonary\"[All Fields] AND \"disease\"[All Fields] AND \"chronic\"[All Fields] AND \"obstructive\"[All Fields]) OR \"chronic obstructive pulmonary disease\"[All Fields] OR \"copd\"[All Fields] OR \"chronic obstructive\"[All Fields] OR (\"emphysema\"[MeSH Terms] OR \"emphysema\"[All Fields] OR \"emphysemas\"[All Fields] OR \"pulmonary emphysema\"[MeSH Terms] OR (\"pulmonary\"[All Fields] AND \"emphysema\"[All Fields]) OR \"pulmonary emphysema\"[All Fields]) OR \"pulmonary rehabilitation\"[All Fields] OR (\"bronchiectasies\"[All Fields] OR \"bronchiectasis\"[MeSH Terms] OR \"bronchiectasis\"[All Fields] OR \"bronchiectases\"[All Fields]) OR \"alpha-1\"[All Fields]) AND 2026/08/28:2026/10/27[Date - Publication]", "count": 1, "ids": [ "42742038" ] } }, "endpoint": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esearch.fcgi", "efetch_record_count": 1360, "other_record_types": 3, "screening": "Compared with prior sweep manifest; screened all 157 newly returned article titles, current randomized-trial/systematic-review/guideline/top-journal query titles and candidate abstracts. Previously triaged unchanged records were not reinterpreted wholesale." }, "cochrane_cdsr": { "queries": { "diagnosis": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (spirometry[tiab] OR diagnosis[tiab] OR \"case finding\"[tiab] OR underdiagnosis[tiab] OR \"lower limit of normal\"[tiab] OR \"pre-COPD\"[tiab] OR PRISm[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"spirometry\"[Title/Abstract] OR \"diagnosis\"[Title/Abstract] OR \"case finding\"[Title/Abstract] OR \"underdiagnosis\"[Title/Abstract] OR \"lower limit of normal\"[Title/Abstract] OR \"pre-COPD\"[Title/Abstract] OR \"PRISm\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "epidemiology": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (prevalence[tiab] OR incidence[tiab] OR mortality[tiab] OR burden[tiab] OR \"Global Burden\"[tiab] OR DALY*[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"prevalence\"[Title/Abstract] OR \"incidence\"[Title/Abstract] OR \"mortality\"[Title/Abstract] OR \"burden\"[Title/Abstract] OR \"Global Burden\"[Title/Abstract] OR \"daly*\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "small_airway_emphysema": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"small airway*\"[tiab] OR \"parametric response\"[tiab] OR \"terminal bronchiole*\"[tiab] OR \"mucus plug*\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"small airway*\"[Title/Abstract] OR \"parametric response\"[Title/Abstract] OR \"terminal bronchiole*\"[Title/Abstract] OR \"mucus plug*\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "inflammation": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (eosinophil*[tiab] OR \"type 2\"[tiab] OR neutrophil*[tiab] OR microbiome[tiab] OR endotype*[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"eosinophil*\"[Title/Abstract] OR \"type 2\"[Title/Abstract] OR \"neutrophil*\"[Title/Abstract] OR \"microbiome\"[Title/Abstract] OR \"endotype*\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "genetics_aatd": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"alpha-1 antitrypsin\"[tiab] OR \"alpha1-antitrypsin\"[tiab] OR AATD[tiab] OR SERPINA1[tiab] OR GWAS[tiab] OR \"polygenic\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"alpha-1 antitrypsin\"[Title/Abstract] OR \"alpha1-antitrypsin\"[Title/Abstract] OR \"AATD\"[Title/Abstract] OR \"SERPINA1\"[Title/Abstract] OR \"GWAS\"[Title/Abstract] OR \"polygenic\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "exposures": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (smoking[tiab] OR \"e-cigarette*\"[tiab] OR biomass[tiab] OR \"air pollution\"[tiab] OR occupational[tiab] OR \"smoking cessation\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"smoking\"[Title/Abstract] OR \"e cigarette*\"[Title/Abstract] OR \"biomass\"[Title/Abstract] OR \"air pollution\"[Title/Abstract] OR \"occupational\"[Title/Abstract] OR \"smoking cessation\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "inhaled_therapy": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (LAMA[tiab] OR LABA[tiab] OR \"inhaled corticosteroid*\"[tiab] OR \"triple therapy\"[tiab] OR budesonide[tiab] OR fluticasone[tiab] OR tiotropium[tiab] OR ensifentrine[tiab] OR inhaler*[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"LAMA\"[Title/Abstract] OR \"LABA\"[Title/Abstract] OR \"inhaled corticosteroid*\"[Title/Abstract] OR \"triple therapy\"[Title/Abstract] OR \"budesonide\"[Title/Abstract] OR \"fluticasone\"[Title/Abstract] OR \"tiotropium\"[Title/Abstract] OR \"ensifentrine\"[Title/Abstract] OR \"inhaler*\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "exacerbations": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (exacerbation*[tiab] OR AECOPD[tiab] OR readmission*[tiab] OR \"noninvasive ventilation\"[tiab] OR \"non-invasive ventilation\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"exacerbation*\"[Title/Abstract] OR \"AECOPD\"[Title/Abstract] OR \"readmission*\"[Title/Abstract] OR \"noninvasive ventilation\"[Title/Abstract] OR \"non-invasive ventilation\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "rehabilitation": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"pulmonary rehabilitation\"[tiab] OR telerehabilitation[tiab] OR \"self-management\"[tiab] OR exercise[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"pulmonary rehabilitation\"[Title/Abstract] OR \"telerehabilitation\"[Title/Abstract] OR \"self-management\"[Title/Abstract] OR \"exercise\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "oxygen_niv": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"long-term oxygen\"[tiab] OR \"oxygen therapy\"[tiab] OR \"home noninvasive\"[tiab] OR \"home non-invasive\"[tiab] OR \"high-flow\"[tiab] OR palliative[tiab] OR breathlessness[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"long-term oxygen\"[Title/Abstract] OR \"oxygen therapy\"[Title/Abstract] OR \"home noninvasive\"[Title/Abstract] OR \"home non-invasive\"[Title/Abstract] OR \"high-flow\"[Title/Abstract] OR \"palliative\"[Title/Abstract] OR \"breathlessness\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "procedures": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"endobronchial valve*\"[tiab] OR \"lung volume reduction\"[tiab] OR \"lung transplant*\"[tiab] OR bronchoscopic[tiab] OR bullectomy[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"endobronchial valve*\"[Title/Abstract] OR \"lung volume reduction\"[Title/Abstract] OR \"lung transplant*\"[Title/Abstract] OR \"bronchoscopic\"[Title/Abstract] OR \"bullectomy\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "comorbidity": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (cardiovascular[tiab] OR cardiopulmonary[tiab] OR \"heart failure\"[tiab] OR osteoporosis[tiab] OR frailty[tiab] OR depression[tiab] OR anxiety[tiab] OR \"lung cancer\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"cardiovascular\"[Title/Abstract] OR \"cardiopulmonary\"[Title/Abstract] OR \"heart failure\"[Title/Abstract] OR \"osteoporosis\"[Title/Abstract] OR \"frailty\"[Title/Abstract] OR \"depression\"[Title/Abstract] OR \"anxiety\"[Title/Abstract] OR \"lung cancer\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "guidelines": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (guideline*[tiab] OR GOLD[tiab] OR \"consensus statement\"[tiab] OR \"position statement\"[tiab] OR \"practice guideline\"[pt]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"guideline*\"[Title/Abstract] OR \"GOLD\"[Title/Abstract] OR \"consensus statement\"[Title/Abstract] OR \"position statement\"[Title/Abstract] OR \"practice guideline\"[Publication Type]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "biomarkers_imaging": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (biomarker*[tiab] OR \"computed tomography\"[tiab] OR \"CT\"[tiab] OR MRI[tiab] OR \"artificial intelligence\"[tiab] OR \"deep learning\"[tiab] OR fibrinogen[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"biomarker*\"[Title/Abstract] OR \"computed tomography\"[Title/Abstract] OR \"CT\"[Title/Abstract] OR \"MRI\"[Title/Abstract] OR \"artificial intelligence\"[Title/Abstract] OR \"deep learning\"[Title/Abstract] OR \"fibrinogen\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "biologics_trials": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (dupilumab[tiab] OR mepolizumab[tiab] OR benralizumab[tiab] OR tezepelumab[tiab] OR itepekimab[tiab] OR tozorakimab[tiab] OR astegolimab[tiab] OR biologic*[tiab] OR \"phase 3\"[tiab] OR \"phase III\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"dupilumab\"[Title/Abstract] OR \"mepolizumab\"[Title/Abstract] OR \"benralizumab\"[Title/Abstract] OR \"tezepelumab\"[Title/Abstract] OR \"itepekimab\"[Title/Abstract] OR \"tozorakimab\"[Title/Abstract] OR \"astegolimab\"[Title/Abstract] OR \"biologic*\"[Title/Abstract] OR \"phase 3\"[Title/Abstract] OR \"phase III\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "patient_experience": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (stigma[tiab] OR qualitative[tiab] OR \"patient experience\"[tiab] OR caregiver*[tiab] OR \"quality of life\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"stigma\"[Title/Abstract] OR \"qualitative\"[Title/Abstract] OR \"patient experience\"[Title/Abstract] OR \"caregiver*\"[Title/Abstract] OR \"quality of life\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "safety": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (pneumonia[tiab] OR pneumothorax[tiab] OR \"respiratory failure\"[tiab] OR hypercapni*[tiab] OR \"adverse event*\"[tiab] OR \"pulmonary embolism\"[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"pneumonia\"[Title/Abstract] OR \"pneumothorax\"[Title/Abstract] OR \"respiratory failure\"[Title/Abstract] OR \"hypercapni*\"[Title/Abstract] OR \"adverse event*\"[Title/Abstract] OR \"pulmonary embolism\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "rcts": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (randomized controlled trial[pt] OR \"randomised\"[ti] OR \"randomized\"[ti]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"randomized controlled trial\"[Publication Type] OR \"randomised\"[Title] OR \"randomized\"[Title]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "systematic_reviews": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (systematic review[pt] OR meta-analysis[pt] OR \"meta-analysis\"[ti] OR \"systematic review\"[ti]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"systematic review\"[Publication Type] OR \"meta-analysis\"[Publication Type] OR \"meta-analysis\"[Title] OR \"systematic review\"[Title]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "top_journals": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"N Engl J Med\"[jour] OR \"Lancet\"[jour] OR \"JAMA\"[jour] OR \"BMJ\"[jour] OR \"Lancet Respir Med\"[jour] OR \"Am J Respir Crit Care Med\"[jour] OR \"Eur Respir J\"[jour] OR \"Chest\"[jour] OR \"Thorax\"[jour] OR \"Nat Med\"[jour] OR \"JAMA Intern Med\"[jour] OR \"Ann Intern Med\"[jour]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND (\"N Engl J Med\"[Journal] OR \"Lancet\"[Journal] OR \"JAMA\"[Journal] OR \"BMJ\"[Journal] OR \"Lancet Respir Med\"[Journal] OR \"Am J Respir Crit Care Med\"[Journal] OR \"Eur Respir J\"[Journal] OR \"Chest\"[Journal] OR \"Thorax\"[Journal] OR \"Nat Med\"[Journal] OR \"JAMA Intern Med\"[Journal] OR \"Ann Intern Med\"[Journal]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "broad": { "query": "\"Cochrane Database Syst Rev\"[jour] AND ((COPD[tiab] OR \"chronic obstructive pulmonary disease\"[tiab] OR \"chronic obstructive lung disease\"[tiab] OR emphysema[tiab]) AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND ((\"COPD\"[Title/Abstract] OR \"chronic obstructive pulmonary disease\"[Title/Abstract] OR \"chronic obstructive lung disease\"[Title/Abstract] OR \"emphysema\"[Title/Abstract]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 0, "ids": [] }, "cochrane": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"Cochrane Database Syst Rev\"[jour] AND (COPD OR \"chronic obstructive\" OR emphysema OR \"pulmonary rehabilitation\" OR bronchiectasis OR \"alpha-1\") AND (\"2026/08/28\"[dp] : \"2026/10/27\"[dp]))", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Cochrane Database Syst Rev\"[Journal] AND (\"pulmonary disease, chronic obstructive\"[MeSH Terms] OR (\"pulmonary\"[All Fields] AND \"disease\"[All Fields] AND \"chronic\"[All Fields] AND \"obstructive\"[All Fields]) OR \"chronic obstructive pulmonary disease\"[All Fields] OR \"copd\"[All Fields] OR \"chronic obstructive\"[All Fields] OR (\"emphysema\"[MeSH Terms] OR \"emphysema\"[All Fields] OR \"emphysemas\"[All Fields] OR \"pulmonary emphysema\"[MeSH Terms] OR (\"pulmonary\"[All Fields] AND \"emphysema\"[All Fields]) OR \"pulmonary emphysema\"[All Fields]) OR \"pulmonary rehabilitation\"[All Fields] OR (\"bronchiectasies\"[All Fields] OR \"bronchiectasis\"[MeSH Terms] OR \"bronchiectasis\"[All Fields] OR \"bronchiectases\"[All Fields]) OR \"alpha-1\"[All Fields]) AND 2026/08/28:2026/10/27[Date - Publication])", "count": 1, "ids": [ "42742038" ] } } }, "europe_pmc": { "queries": { "diagnosis": { "query": "(TITLE_ABS:COPD OR TITLE_ABS:\"chronic obstructive pulmonary disease\" OR TITLE_ABS:\"chronic obstructive lung disease\" OR TITLE_ABS:emphysema) AND (TITLE_ABS:spirometry OR TITLE_ABS:diagnosis OR TITLE_ABS:\"case finding\" OR TITLE_ABS:underdiagnosis OR TITLE_ABS:\"lower limit of normal\" OR TITLE_ABS:\"pre-COPD\" OR TITLE_ABS:PRISm) AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 164, "ids": [ [ "MED", "42766492" ], [ "MED", "42904526" ], [ "MED", "42706206" ], [ "MED", "42807840" ], [ "MED", "42796426" ], [ "MED", "42867256" ], [ "MED", "42914685" ], [ "MED", "42899456" ], [ "MED", "42902645" ], [ "MED", "42421199" ], [ "MED", "42763198" ], [ "MED", "42793493" ], [ "MED", "42744412" ], [ "MED", "42707541" ], [ "MED", "42665061" ], [ "MED", "42923669" ], [ "MED", "42789746" ], [ "MED", "42831112" ], [ "MED", "42889156" ], [ "MED", "42743080" ], [ "MED", "42844875" ], [ "MED", "42826728" ], [ "MED", "42417387" ], [ "MED", "42857998" ], [ "MED", "42865211" ], [ "MED", "42330343" ], [ "MED", "42923616" ], [ "MED", "42922284" ], [ "MED", "42681260" ], [ "MED", "42843053" ], [ "PPR", "PPR1319633" ], [ "MED", "42829719" ], [ "MED", "42894652" ], [ "MED", "42806974" ], [ "MED", "42833476" ], [ "MED", "42881572" ], [ "MED", "42907946" ], [ "MED", "42802932" ], [ "MED", 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obstructive pulmonary disease\" OR TITLE_ABS:\"chronic obstructive lung disease\" OR TITLE_ABS:emphysema) AND (TITLE_ABS:prevalence OR TITLE_ABS:incidence OR TITLE_ABS:mortality OR TITLE_ABS:burden OR TITLE_ABS:\"Global Burden\" OR TITLE_ABS:DALY*) AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 352, "ids": [ [ "MED", "42898698" ], [ "MED", "42891260" ], [ "MED", "42756486" ], [ "MED", "42812767" ], [ "MED", "42893247" ], [ "MED", "42763704" ], [ "MED", "42924627" ], [ "MED", "42859980" ], [ "MED", "42753772" ], [ "MED", "42890759" ], [ "MED", "42831088" ], [ "MED", "42902645" ], [ "MED", "42330343" ], [ "MED", "42865211" ], [ "MED", "42831112" ], [ "MED", "42875068" ], [ "MED", "42841936" ], [ "MED", "42816088" ], [ "MED", "42674271" ], [ "MED", "42763198" ], [ "MED", "42333497" ], [ "MED", "42705339" ], [ "MED", "42681260" ], [ "MED", "42765005" ], [ "MED", "41733233" ], [ "MED", "42905901" ], [ "MED", "42667442" ], [ "MED", "42888584" ], [ "MED", "42770007" ], [ "PPR", "PPR1323313" ], [ "MED", "42739805" ], [ "PPR", "PPR1326382" ], [ "MED", "42871116" ], [ "MED", "42885319" ], [ "MED", "42899181" ], [ "MED", "42767479" ], [ "MED", "42809997" ], [ "MED", "42826321" ], [ "MED", "42898870" ], [ "MED", "42857644" ], [ "MED", "42920844" ], [ "MED", "42761905" ], [ "MED", "42908640" ], [ "PMC", "PMC13691444" ], [ "MED", "42923616" ], [ "MED", "42921797" ], [ "MED", "42826728" ], [ "MED", "42881075" ], [ "MED", "41950377" ], [ "PMC", "PMC13651490" ], [ "MED", "42907946" ], [ "MED", "42921587" ], [ "MED", "42897393" ], [ "MED", "42754632" ], [ "MED", "42705490" ], [ "PPR", "PPR1331268" ], [ "MED", "42741722" ], [ "MED", "42679174" ], [ "MED", "42706206" ], [ "MED", "42852893" ], [ "MED", "42807417" ], [ "MED", "42249531" ], [ "MED", "42881689" ], [ "MED", "42838239" ], [ "PPR", "PPR1323027" ], [ "MED", "42855085" ], [ "MED", "42904136" ], [ "MED", "42898520" ], [ "MED", "42805833" ], [ "PPR", "PPR1346252" ], [ "MED", "42899177" ], [ "MED", "42805994" ], [ 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"MED", "42845158" ], [ "MED", "42769106" ], [ "MED", "42746804" ], [ "MED", "42803494" ], [ "MED", "42782493" ], [ "MED", "42884123" ], [ "MED", "42705504" ], [ "MED", "42704890" ], [ "MED", "42906349" ], [ "MED", "42924737" ], [ "MED", "42816626" ], [ "MED", "42798561" ], [ "MED", "42707527" ], [ "MED", "41644135" ], [ "MED", "42728228" ], [ "MED", "42711111" ], [ "PPR", "PPR1350473" ], [ "MED", "42242757" ], [ "MED", "42807842" ], [ "MED", "40549596" ], [ "PPR", "PPR1315385" ], [ "MED", "42663560" ], [ "MED", "42759155" ] ] }, "small_airway_emphysema": { "query": "(TITLE_ABS:COPD OR TITLE_ABS:\"chronic obstructive pulmonary disease\" OR TITLE_ABS:\"chronic obstructive lung disease\" OR TITLE_ABS:emphysema) AND (TITLE_ABS:\"small airway*\" OR TITLE_ABS:\"parametric response\" OR TITLE_ABS:\"terminal bronchiole*\" OR TITLE_ABS:\"mucus plug*\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 24, "ids": [ [ "MED", "42914685" ], [ "MED", "42762984" ], [ "MED", "42766492" ], [ "MED", "42330343" ], [ "MED", "42330336" ], [ "MED", "42701782" ], [ "PPR", "PPR1326015" ], [ "MED", "42719853" ], [ "MED", "42922284" ], [ "PPR", "PPR1319633" ], [ "MED", "42814120" ], [ "MED", "42881572" ], [ "PPR", "PPR1347747" ], [ "MED", "42802932" ], [ "MED", "42864666" ], [ "MED", "42776695" ], [ "MED", "42562589" ], [ "MED", "42838277" ], [ "PPR", "PPR1332317" ], [ "MED", "42805317" ], [ "MED", "42746077" ], [ "MED", "42769032" ], [ "MED", "42807081" ], [ "MED", "42770821" ] ] }, "inflammation": { "query": "(TITLE_ABS:COPD OR TITLE_ABS:\"chronic obstructive pulmonary disease\" OR TITLE_ABS:\"chronic obstructive lung disease\" OR TITLE_ABS:emphysema) AND (TITLE_ABS:eosinophil* OR TITLE_ABS:\"type 2\" OR TITLE_ABS:neutrophil* OR TITLE_ABS:microbiome OR TITLE_ABS:endotype*) AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 132, "ids": [ [ "MED", "42756486" ], [ "MED", "42831088" ], [ "MED", "42928777" ], [ "MED", "42921543" ], [ "MED", "42782552" ], [ "MED", "42830888" ], [ "MED", "42265988" ], [ "MED", "42923669" ], [ "MED", "42667442" ], [ "MED", "42770007" ], [ "MED", "42089304" ], [ "MED", "42921797" ], [ "MED", "42767594" ], [ "MED", "42907946" ], [ "MED", "42831046" ], [ "MED", "42871116" ], [ "MED", "42834959" ], [ "MED", "42856088" ], [ "PPR", "PPR1308671" ], [ "PPR", "PPR1329202" ], [ "MED", "42674271" ], [ "MED", "42750861" ], [ "MED", "42839826" ], [ "MED", "42866550" ], [ "MED", "42153327" ], [ "MED", "42701775" ], [ "MED", "42882468" ], [ "MED", "42148875" ], [ "MED", "42773542" ], [ "MED", "42802784" ], [ "MED", "42878116" ], [ "PPR", "PPR1328483" ], [ "MED", "42734898" ], [ "MED", "42894652" ], [ "MED", "42869731" ], [ "PPR", "PPR1337181" ], [ "MED", "42761905" ], [ "MED", "42795312" ], [ "MED", "42726765" ], [ "MED", "42855724" ], [ "MED", "42829170" ], [ "MED", "42898768" ], [ "PPR", "PPR1323063" ], [ "MED", "42727368" ], [ "MED", "42330336" ], [ "MED", "42928917" ], [ "MED", "42920623" ], [ "MED", "42656167" ], [ "PPR", "PPR1347747" ], [ "PPR", "PPR1338642" ], [ "MED", "42747060" ], [ "MED", "42805097" ], [ "MED", "42760677" ], [ "MED", "42776697" ], [ "MED", "42864764" ], [ "MED", "42751152" ], [ "PPR", "PPR1328062" ], [ "MED", "42724737" ], [ "MED", "42665061" ], [ "MED", "42831943" ], [ "MED", "42699792" ], [ "MED", "42880940" ], [ "PPR", "PPR1316761" ], [ "MED", "42785630" ], [ "MED", "42741717" ], [ "MED", "42845784" ], [ "MED", "42801161" ], [ "MED", "42769032" ], [ "MED", "42826271" ], [ "MED", "42882316" ], [ "MED", "42708515" ], [ "MED", "42792707" ], [ "MED", "42778035" ], [ "MED", "42889372" ], [ "MED", "42930048" ], [ "MED", "42839285" ], [ "MED", "42700427" ], [ "MED", "42808452" ], [ "MED", "42872211" ], [ "PMC", "PMC13690786" ], [ "MED", "42921042" ], [ "MED", "42813234" ], [ "MED", "42682871" ], [ "MED", "42562589" ], [ "MED", "42838277" ], [ "MED", "42796263" ], [ "MED", "42697279" ], [ "MED", "42707303" ], [ "MED", "42806973" ], [ "MED", "42750333" ], [ "MED", "42904223" ], [ "PPR", "PPR1330478" ], [ "MED", "42820095" ], [ "MED", "42858866" ], [ "MED", "42821775" ], [ "MED", "42760939" ], [ "PMC", "PMC13642290" ], [ "PMC", "PMC13658142" ], [ "PMC", "PMC13664007" ], [ "MED", "42877096" ], [ "MED", "42882047" ], [ "MED", "42682833" ], [ "MED", "42769092" ], [ "MED", "42683175" ], [ "MED", "42747294" ], [ "MED", "42750319" ], [ "MED", "42148905" ], [ "MED", "42671054" ], [ "MED", "42825262" ], [ "MED", "42816626" ], [ "MED", "42682881" ], [ "MED", "42860278" ], [ "MED", "42803733" ], [ "MED", "42812739" ], [ "MED", "42805332" ], [ "MED", "42781194" ], [ "MED", "42716515" ], [ "MED", "42760212" ], [ "MED", "42242757" ], [ "PPR", "PPR1320929" ], [ "MED", "42866360" ], [ "MED", "42795352" ], [ "MED", "42769106" ], [ "MED", "42906940" ], [ "MED", "42805959" ], [ "MED", "42793803" ], [ "MED", "42843847" ], [ "MED", "42821483" ], [ "MED", "42901244" ], [ "PPR", "PPR1334800" ], [ "MED", "42906349" ], [ "MED", "42067210" ] ] }, "genetics_aatd": { "query": "(TITLE_ABS:COPD OR TITLE_ABS:\"chronic obstructive pulmonary disease\" OR TITLE_ABS:\"chronic obstructive lung disease\" OR TITLE_ABS:emphysema) AND (TITLE_ABS:\"alpha-1 antitrypsin\" OR TITLE_ABS:\"alpha1-antitrypsin\" OR TITLE_ABS:AATD OR TITLE_ABS:SERPINA1 OR TITLE_ABS:GWAS OR TITLE_ABS:\"polygenic\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 19, "ids": [ [ "PPR", "PPR1346764" ], [ "PPR", "PPR1320028" ], [ "MED", "42823318" ], [ "MED", "42805959" ], [ "MED", "42908640" ], [ "MED", "42841174" ], [ "MED", "42741722" ], [ "MED", "42758741" ], [ "MED", "42774110" ], [ "PPR", "PPR1322415" ], [ "MED", "42850118" ], [ "MED", "42879152" ], [ "MED", "42806886" ], [ "MED", "42745457" ], [ "MED", "42751338" ], [ "MED", "42750455" ], [ "MED", "42713628" ], [ "MED", "42744204" ], [ "MED", "42682829" ] ] }, "exposures": { "query": "(TITLE_ABS:COPD OR TITLE_ABS:\"chronic obstructive pulmonary disease\" OR TITLE_ABS:\"chronic obstructive lung disease\" OR TITLE_ABS:emphysema) AND (TITLE_ABS:smoking OR TITLE_ABS:\"e-cigarette*\" OR TITLE_ABS:biomass OR TITLE_ABS:\"air pollution\" OR TITLE_ABS:occupational OR TITLE_ABS:\"smoking cessation\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 155, "ids": [ [ "MED", "42867256" ], [ "MED", "42774110" ], [ "MED", "42859980" ], [ "MED", "42756486" ], [ "MED", "42705490" ], [ "MED", "42663928" ], [ "MED", "42898698" ], [ "MED", "42820089" ], [ "MED", "42788667" ], [ "MED", "42921783" ], [ "MED", "42805834" ], [ "MED", "42813636" ], [ "MED", "42761905" ], [ "MED", "42659031" ], [ "MED", "42793634" ], [ "MED", "42902645" ], [ "MED", "42743080" ], [ "MED", "42865211" ], [ "MED", "42734163" ], [ "MED", "42763198" ], [ "MED", "42889156" ], [ "MED", "42701440" ], [ "MED", "42897393" ], [ "PPR", "PPR1314574" ], [ "MED", "42773542" ], [ "MED", "42923669" ], [ "MED", "42831475" ], [ "MED", "42877639" ], [ "MED", "42922284" ], [ "MED", "42742863" ], [ "MED", "42827947" ], [ "MED", "42699267" ], [ "MED", "42674270" ], [ "MED", "42908640" ], [ 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(TITLE_ABS:LAMA OR TITLE_ABS:LABA OR TITLE_ABS:\"inhaled corticosteroid*\" OR TITLE_ABS:\"triple therapy\" OR TITLE_ABS:budesonide OR TITLE_ABS:fluticasone OR TITLE_ABS:tiotropium OR TITLE_ABS:ensifentrine OR TITLE_ABS:inhaler*) AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 59, "ids": [ [ "MED", "42930048" ], [ "MED", "42773542" ], [ "MED", "42741955" ], [ "MED", "42756486" ], [ "MED", "42904140" ], [ "MED", "42882183" ], [ "MED", "42914145" ], [ "MED", "42819502" ], [ "MED", "42875068" ], [ "MED", "42871116" ], [ "MED", "42281286" ], [ "MED", "42667442" ], [ "MED", "42798039" ], [ "MED", "42521643" ], [ "MED", "42799591" ], [ "MED", "42899177" ], [ "MED", "42831088" ], [ "MED", "42907700" ], [ "MED", "42887045" ], [ "MED", "42887614" ], [ "MED", "42833477" ], [ "MED", "42683865" ], [ "MED", "42831046" ], [ "MED", "42782552" ], [ "MED", "42549852" ], [ "MED", "42775283" ], [ "PPR", "PPR1316761" ], [ "MED", "42905901" ], [ "MED", "42796263" ], [ "MED", "42795312" ], [ "MED", 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FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 253, "ids": [ [ "MED", "42766492" ], [ "MED", "42921783" ], [ "MED", "42841509" ], [ "MED", "42904526" ], [ "MED", "42859980" ], [ "MED", "42908195" ], [ "MED", "42829719" ], [ "MED", "42756486" ], [ "MED", "42881801" ], [ "MED", "42734176" ], [ "MED", "42762984" ], [ "MED", "42801650" ], [ "MED", "42914685" ], [ "MED", "42818656" ], [ "MED", "42727368" ], [ "MED", "42876922" ], [ "MED", "42924627" ], [ "MED", "42852899" ], [ "MED", "42928902" ], [ "PMC", "PMC13577940" ], [ "MED", "42700427" ], [ "MED", "42776308" ], [ "MED", "42741717" ], [ "MED", "42871085" ], [ "MED", "42683865" ], [ "MED", "42903200" ], [ "MED", "42885332" ], [ "MED", "42901278" ], [ "MED", "42701340" ], [ "MED", "42898293" ], [ "MED", "42865926" ], [ "MED", "42898894" ], [ "MED", "42823634" ], [ "MED", "42705339" ], [ "MED", "42761937" ], [ "MED", "42912560" ], [ "MED", "42826271" ], [ "PPR", "PPR1323313" ], [ "MED", "42928777" ], [ "MED", "42906829" ], [ "PPR", 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"(TITLE_ABS:COPD OR TITLE_ABS:\"chronic obstructive pulmonary disease\" OR TITLE_ABS:\"chronic obstructive lung disease\" OR TITLE_ABS:emphysema) AND (TITLE_ABS:\"pulmonary rehabilitation\" OR TITLE_ABS:telerehabilitation OR TITLE_ABS:\"self-management\" OR TITLE_ABS:exercise) AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 90, "ids": [ [ "MED", "42877639" ], [ "MED", "42733827" ], [ "MED", "42881075" ], [ "PMC", "PMC13662792" ], [ "MED", "42855085" ], [ "MED", "42885319" ], [ "MED", "42897042" ], [ "MED", "42898520" ], [ "MED", "42828082" ], [ "MED", "42852888" ], [ "MED", "42913179" ], [ "MED", "42930050" ], [ "MED", "42859980" ], [ "MED", "42810416" ], [ "MED", "42666801" ], [ "MED", "42766845" ], [ "MED", "42622334" ], [ "MED", "42914006" ], [ "MED", "42772467" ], [ "MED", "42705339" ], [ "MED", "42679174" ], [ "PPR", "PPR1345864" ], [ "MED", "42838838" ], [ "MED", "42928679" ], [ "MED", "42248680" ], [ "MED", "42910776" ], [ "MED", "42863686" ], [ "MED", "42910133" ], [ 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"42880459" ], [ "MED", "42913274" ], [ "MED", "42705339" ], [ "MED", "42831112" ], [ "MED", "42813981" ], [ "MED", "42872922" ], [ "MED", "42912560" ], [ "MED", "42852893" ], [ "MED", "42823634" ], [ "MED", "42726765" ], [ "MED", "42898520" ], [ "PPR", "PPR1331613" ], [ "MED", "42892394" ], [ "MED", "42871142" ], [ "MED", "42749468" ], [ "MED", "42685648" ], [ "MED", "42761905" ], [ "MED", "42760127" ], [ "MED", "42775276" ], [ "MED", "42809997" ], [ "MED", "42660530" ], [ "MED", "42699708" ], [ "PPR", "PPR1336842" ], [ "MED", "42796426" ], [ "MED", "42842938" ], [ "MED", "42899053" ], [ "MED", "42739212" ], [ "MED", "42782261" ], [ "MED", "42841174" ], [ "MED", "42897575" ], [ "MED", "42767802" ], [ "MED", "42728228" ], [ "MED", "42663560" ], [ "MED", "42871890" ], [ "MED", "42807081" ], [ "MED", "42833910" ], [ "MED", "42813308" ], [ "MED", "42888100" ], [ "MED", "42783486" ], [ "MED", "42921241" ], [ "MED", "42871153" ], [ "MED", "42859312" ], [ "MED", "42793525" ], [ "MED", 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[ "MED", "41856570" ], [ "MED", "42781194" ], [ "MED", "42854034" ] ] }, "comorbidity": { "query": "(TITLE_ABS:COPD OR TITLE_ABS:\"chronic obstructive pulmonary disease\" OR TITLE_ABS:\"chronic obstructive lung disease\" OR TITLE_ABS:emphysema) AND (TITLE_ABS:cardiovascular OR TITLE_ABS:cardiopulmonary OR TITLE_ABS:\"heart failure\" OR TITLE_ABS:osteoporosis OR TITLE_ABS:frailty OR TITLE_ABS:depression OR TITLE_ABS:anxiety OR TITLE_ABS:\"lung cancer\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 239, "ids": [ [ "MED", "42767479" ], [ "MED", "42921783" ], [ "MED", "42921587" ], [ "MED", "42902645" ], [ "MED", "42865211" ], [ "MED", "42885319" ], [ "MED", "42928679" ], [ "MED", "42765005" ], [ "MED", "42898293" ], [ "PPR", "PPR1331268" ], [ "PMC", "PMC13641682" ], [ "MED", "41795868" ], [ "MED", "41802233" ], [ "MED", "42743080" ], [ "MED", "42800650" ], [ "MED", "42827947" ], [ "MED", "42701440" ], [ "PPR", "PPR1338642" ], [ "MED", "42767594" ], [ "MED", "42891260" ], [ "MED", 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"42845158" ], [ "MED", "42830122" ], [ "MED", "42926887" ], [ "PPR", "PPR1350473" ] ] }, "guidelines": { "query": "(TITLE_ABS:COPD OR TITLE_ABS:\"chronic obstructive pulmonary disease\" OR TITLE_ABS:\"chronic obstructive lung disease\" OR TITLE_ABS:emphysema) AND (TITLE_ABS:guideline* OR TITLE_ABS:GOLD OR TITLE_ABS:\"consensus statement\" OR TITLE_ABS:\"position statement\" OR \"practice guideline\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 122, "ids": [ [ "MED", "42766492" ], [ "MED", "42904526" ], [ "MED", "42756486" ], [ "MED", "42813636" ], [ "MED", "42867256" ], [ "MED", "42898293" ], [ "MED", "42667442" ], [ "MED", "42921783" ], [ "MED", "42852888" ], [ "MED", "42924627" ], [ "MED", "42899456" ], [ "MED", "42902645" ], [ "MED", "42701782" ], [ "MED", "42741955" ], [ "MED", "42841509" ], [ "MED", "42907946" ], [ "MED", "42889156" ], [ "MED", "42745881" ], [ "MED", "42706206" ], [ "MED", "42831112" ], [ "MED", "42865811" ], [ "MED", "42674270" ], [ "MED", "42779315" ], 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FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 0, "ids": [] }, "systematic_reviews": { "query": "(TITLE_ABS:COPD OR TITLE_ABS:\"chronic obstructive pulmonary disease\" OR TITLE_ABS:\"chronic obstructive lung disease\" OR TITLE_ABS:emphysema) AND (systematic review OR meta-analysis OR \"meta-analysis\"[ti] OR \"systematic review\"[ti]) AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 0, "ids": [] }, "top_journals": { "query": "(TITLE_ABS:COPD OR TITLE_ABS:\"chronic obstructive pulmonary disease\" OR TITLE_ABS:\"chronic obstructive lung disease\" OR TITLE_ABS:emphysema) AND (\"N Engl J Med\" OR \"Lancet\" OR \"JAMA\" OR \"BMJ\" OR \"Lancet Respir Med\" OR \"Am J Respir Crit Care Med\" OR \"Eur Respir J\" OR \"Chest\" OR \"Thorax\" OR \"Nat Med\" OR \"JAMA Intern Med\" OR \"Ann Intern Med\") AND FIRST_PDATE:[2026-08-28 TO 2026-10-27]", "count": 298, "ids": [ [ "MED", "42788667" ], [ "MED", "42184284" ], [ "MED", "42363406" ], [ "MED", "42363405" ], [ "MED", "42548115" ], [ "MED", 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Obstructive Pulmonary Disease (COPD)", "status": "COMPLETED", "lastUpdate": "2026-10-15", "hasResults": true, "resultsFirstPost": "2026-10-15", "statusModule": { "statusVerifiedDate": "2026-09", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2020-12-16", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2025-04-11", "type": "ACTUAL" }, "completionDateStruct": { "date": "2025-08-27", "type": "ACTUAL" }, "studyFirstSubmitDate": "2020-12-30", "studyFirstSubmitQcDate": "2021-01-06", "studyFirstPostDateStruct": { "date": "2021-01-08", "type": "ACTUAL" }, "resultsFirstSubmitDate": "2026-08-27", "resultsFirstSubmitQcDate": "2026-09-22", "resultsFirstPostDateStruct": { "date": "2026-10-15", "type": "ACTUAL" }, "dispFirstSubmitDate": "2026-04-09", "dispFirstPostDateStruct": { "date": "2026-10-15", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-09-22", "lastUpdatePostDateStruct": { "date": "2026-10-15", "type": "ACTUAL" } }, "results_sha256": "4df56a8c0e8c7fa0e12acb55c6337b31f497a0e081062aed4dab33d440a389d2", "primary_outcomes": [ { "type": "PRIMARY", "title": "Annualized Rate of Adjudicated Moderate or Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) Events Over the Placebo-Controlled Treatment Period", "description": "Exacerbations were recorded by Investigator. Moderate exacerbations were defined as acute worsening of respiratory symptoms that required either systemic corticosteroids (such as intramuscular \\[IM\\], intravenous \\[IV\\], or oral) and/or antibiotics. Severe exacerbations were defined as AECOPD that required hospitalization, observation for \\>24 hours in an emergency department/urgent care facility, or resulted in death. For both moderate and severe events to be counted as 2 separate events, they must be separated by at least 14 days between any course of systemic steroids/antibiotics or 14 days between discharge and new admission in case of hospitalization (severe events only). Annualized rate was the total number of moderate or severe exacerbation events divided by the total observation duration and was estimated based on negative binomial regression. Events were adjudicated by third party.", "populationDescription": "The intent-to-treat (ITT) population included randomized participants from both 52 weeks treatment duration portion and variable treatment duration portion.", "reportingStatus": "POSTED", "paramType": "NUMBER", "dispersionType": "95% Confidence Interval", "unitOfMeasure": "events per participant year", "timeFrame": "Baseline (Day 1) up to Week 52 for initial randomized participants; Baseline (Day 1) up to Week 24 to 52 for additional randomized participants", "groups": [ { "id": "OG000", "title": "Placebo Q2W", "description": "Participants received placebo matching itepekimab as an SC injection Q2W for up to 52 weeks." }, { "id": "OG001", "title": "Itepekimab 300 mg Q4W", "description": "Participants received itepekimab 300 mg as an SC injection Q4W with alternating placebo matching itepekimab administration at the 2-week interval between active study drug for up to 52 weeks." }, { "id": "OG002", "title": "Itepekimab 300 mg Q2W", "description": "Participants received itepekimab 300 mg as an SC injection Q2W for up to 52 weeks." } ], "denoms": [ { "units": "Participants", "counts": [ { "groupId": "OG000", "value": "375" }, { "groupId": "OG001", "value": "377" }, { "groupId": "OG002", "value": "375" } ] } ], "classes": [ { "categories": [ { "measurements": [ { "groupId": "OG000", "value": "0.891", "spread": "0.763", "lowerLimit": "0.763", "upperLimit": "1.042" }, { "groupId": "OG001", "value": "0.708", "spread": "0.602", "lowerLimit": "0.602", "upperLimit": "0.834" }, { "groupId": "OG002", "value": "0.650", "spread": "0.550", "lowerLimit": "0.550", "upperLimit": "0.768" } ] } ] } ], "analyses": [ { "groupIds": [ "OG000", "OG001" ], "groupDescription": "Derived from negative binomial regression model with total number of events occurring during observation duration as response variable, treatment group, eosinophil randomization strata, controller therapy randomization strata, region, number of severe AECOPD events experienced in previous year(0 vs 1+) at baseline, and post-bronchodilator(post-BD) forced expiratory volume in one second(FEV1) percent predicted at baseline as covariates and log-transformed observation duration as offset variable.", "nonInferiorityType": "SUPERIORITY", "nonInferiorityComment": "A hierarchical testing procedure was used to control overall type I error. Primary endpoint was tested at 2-sided significance level of 0.049, after which alpha was split. Endpoint of annualized rate of severe AECOPD was tested based on significance level of 0.02, while remaining 6 secondary efficacy endpoints were tested at significance level of 0.029 for comparison between itepekimab (300 mg Q2W or 300 mg Q4W) and placebo. Testing was performed sequentially in order endpoints are reported.", "pValue": "= 0.0213", "statisticalMethod": "Negative binomial regression model", "paramType": "Rate ratio", "paramValue": "0.795", "ciPctValue": "95", "ciNumSides": "TWO_SIDED", "ciLowerLimit": "0.654", "ciUpperLimit": "0.966" }, { "groupIds": [ "OG000", "OG002" ], "groupDescription": "Derived from negative binomial regression model with the total number of events occurring during the observation duration as response variable, treatment group, eosinophil randomization strata, controller therapy randomization strata, region, number of severe AECOPD events experienced in previous year (0 vs. 1+) at baseline, and post-BD FEV1 percent predicted at baseline as covariates, and the log-transformed observation duration as the offset variable.", "nonInferiorityType": "SUPERIORITY", "nonInferiorityComment": "A hierarchical testing procedure was used to control overall type I error. Primary endpoint was tested at 2-sided significance level of 0.049, after which alpha was split. Endpoint of annualized rate of severe AECOPD was tested based on significance level of 0.02, while remaining 6 secondary efficacy endpoints were tested at significance level of 0.029 for comparison between itepekimab (300 mg Q2W or 300 mg Q4W) and placebo. Testing was performed sequentially in order endpoints are reported.", "pValue": "= 0.0019", "statisticalMethod": "Negative binomial regression model", "paramType": "Rate ratio", "paramValue": "0.729", "ciPctValue": "95", "ciNumSides": "TWO_SIDED", "ciLowerLimit": "0.598", "ciUpperLimit": "0.890" } ] } ], "eligibilityCriteria": "Inclusion criteria :\n\n* Participant must be 40 to 85 years of age inclusive\n* Physician diagnosis of COPD for at least 1 year (based on Global Initiative for Chronic Obstructive Lung Disease \\[GOLD\\] definition)\n* Smoking history of ≥10 pack-years, but who were not currently smoking, and smoking cessation must have occurred ≥6 months prior to Screening (Visit 1A) with an intention to quit permanently\n* Participants with moderate-to-severe COPD\n* Participant-reported history of signs and symptoms of chronic bronchitis (chronic productive cough for at least 3 months in the year prior to screening in a participant in whom other causes of chronic cough \\[eg, inadequately treated gastroesophageal reflux or chronic rhinosinusitis; or clinical diagnosis of bronchiectasis\\] has been excluded)\n* Documented history of high exacerbation risk defined as having had ≥2 moderate or ≥1 severe exacerbations within the year prior to Screening (Visit 1A), with at least 1 exacerbation treated with systemic corticosteroids. At least one exacerbation must have occurred while participants were on their current controller therapy:\n\n * Moderate exacerbations were recorded by the Investigator and were defined as acute worsening of respiratory symptoms that requires either systemic corticosteroids (IM, IV, or oral) and/or antibiotics\n * Severe exacerbations were recorded by the Investigator and were defined as AECOPD that require hospitalization or observation for \\>24 hours in emergency department/urgent care facility\n* Participants with standard of care controller therapy, for ≥3 months prior to Screening (Visit 1A) and at a stable dose of controller therapy for at least 1 month prior to the screening, including either: inhaled corticosteroid (ICS) + long-acting beta-agonist (LABA), long-acting muscarinic antagonist (LAMA) + LABA or LAMA + LABA + ICS\n* Body mass index (BMI) ≥18.0 kg/m\\^2, or BMI ≥16.0 kg/m\\^2 for participants enrolled in East-Asian countries\n* Female participant was not pregnant, not breastfeeding, and at least one of the following conditions applies:\n\n * not a women of child-bearing potential (WOCBP) OR\n * a WOCBP who agrees to follow the contraceptive guidance during the intervention period and for at least 20 weeks after the last dose of study intervention\n\nExclusion criteria:\n\n* Current diagnosis of asthma according to the Global Initiative for Asthma (GINA) guidelines, or documented history of asthma unless asthma resolved before 18 years of age and has not recurred\n* Active smoking or vaping of any products (eg, nicotine, tetrahydrocannabinol \\[THC\\]) within 6 months prior to Screening (Visit 1A)\n* Clinically significant new abnormal electrocardiogram (ECG) within 6 months prior to, or at Screening (Visit 1A) that may affect the participant's participation in the study\n* Clinically significant and current pulmonary disease other than COPD, eg, sarcoidosis, interstitial lung disease, bronchiectasis (clinical diagnosis), diagnosis of α-1 anti-trypsin deficiency, or another diagnosed pulmonary disease\n* Diagnosis of cor pulmonale, evidence of right cardiac failure, or moderate-to-severe pulmonary hypertension\n* Hypercapnia requiring bilevel positive airway pressure (BiPAP)\n* Moderate or severe exacerbation of COPD (AECOPD) within 4 weeks prior to Screening (Visit 1A)\n* Prior history of / planned: lung pneumonectomy for any reason, or lung volume reduction procedures (including bronchoscopic volume reduction) for COPD. Note: Surgical biopsy, or segmentectomy, or wedge resection, or lobectomy for other diseases would not be excluded.\n* Unstable ischemic heart disease, including acute myocardial infarction within the past 1 year prior to Screening, or unstable angina in the 6 months prior to Screening (Visit 1A)\n* Cardiac arrhythmias including paroxysmal (eg, intermittent) atrial fibrillation\n* Uncontrolled hypertension (ie, systolic blood pressure \\[BP\\] \\>180 mm Hg or diastolic BP \\>110 mm Hg with or without use of anti-hypertensive therapy)\n* Participants with active tuberculosis (TB), latent TB, a history of incompletely treated TB, suspected extrapulmonary TB infection (TBI), or who were at high risk of contracting TB (such as close contact with individuals with active or latent TB) or received Bacillus Calmette-Guérin (BCG)-vaccination within 12 weeks prior to Screening (Visit 1A)\n* History of human immunodeficiency virus (HIV) infection or positive HIV 1/2 serology at Screening (Visit 1A)\n* Suspicion of, or confirmed, coronavirus disease 2019 (COVID-19) infection or in contact with known exposure to COVID-19 at Screening (Visit 1A); known history of COVID-19 infection within 4 weeks prior to Screening (Visit 1A); history of requiring mechanical ventilation or extracorporeal membrane oxygenation (ECMO) secondary to COVID-19 within 3 months prior to sScreening (Visit 1A); participants who have had a COVID-19 infection prior Screening (Visit 1A) who have not yet sufficiently recovered to participate in the procedures of a clinical trial\n* Evidence of acute or chronic infection requiring systemic treatment with antibacterial, antiviral, antifungal, antiparasitic, or antiprotozoal medications within 4 weeks before Screening (Visit 1A), significant viral infections within 4 weeks before Screening (Visit 1A) that may not have been treated with antiviral treatment (eg, influenza receiving only symptomatic treatment)\n* Participants with active autoimmune disease or participants using immunosuppressive therapy for autoimmune disease (eg, rheumatoid arthritis, inflammatory bowel disease, primary biliary cirrhosis, systemic lupus erythematosus, multiple sclerosis\n* History of malignancy within 5 years before Screening (Visit 1A), except completely treated in situ carcinoma of the cervix, completely treated and resolved nonmetastatic squamous or basal cell carcinoma of the skin\n* Previous use of itepekimab\n\nThe above information was not intended to contain all considerations relevant to a participant's potential participation in a clinical trial." }, "NCT04751487": { "title": "Study to Assess the Efficacy, Safety, and Tolerability of SAR440340/REGN3500/Itepekimab in Chronic Obstructive Pulmonary Disease (COPD)", "status": "COMPLETED", "lastUpdate": "2026-10-09", "hasResults": true, "resultsFirstPost": "2026-10-09", "statusModule": { "statusVerifiedDate": "2026-10", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2021-02-12", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2025-04-21", "type": "ACTUAL" }, "completionDateStruct": { "date": "2025-08-28", "type": "ACTUAL" }, "studyFirstSubmitDate": "2021-02-08", "studyFirstSubmitQcDate": "2021-02-08", "studyFirstPostDateStruct": { "date": "2021-02-12", "type": "ACTUAL" }, "resultsFirstSubmitDate": "2026-09-16", "resultsFirstSubmitQcDate": "2026-10-08", "resultsFirstPostDateStruct": { "date": "2026-10-09", "type": "ACTUAL" }, "dispFirstSubmitDate": "2026-04-09", "dispFirstPostDateStruct": { "date": "2026-10-09", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-10-08", "lastUpdatePostDateStruct": { "date": "2026-10-09", "type": "ACTUAL" } }, "results_sha256": "0dfebbfce18fec3214bcd75e25314a28eb51c02c5fae825e46dbe60df48be908", "primary_outcomes": [ { "type": "PRIMARY", "title": "Former Smoker Cohort: Annualized Rate of Adjudicated Moderate or Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) Events Over the 52-Week Placebo-Controlled Treatment Period", "description": "Exacerbations were recorded by Investigator. Moderate exacerbations were defined as acute worsening of respiratory symptoms that required either systemic corticosteroids (such as intramuscular \\[IM\\], intravenous \\[IV\\], or oral) and/or antibiotics. Severe exacerbations were defined as AECOPD that required hospitalization, observation for \\>24 hours in an emergency department/urgent care facility, or resulted in death. For both moderate and severe events to be counted as 2 separate events, they must be separated by at least 14 days between any course of systemic steroids/antibiotics or 14 days between discharge and new admission in case of hospitalization (severe events only). Annualized rate was total number of moderate or severe exacerbation events divided by total observation duration and was estimated based on negative binomial regression. Events were adjudicated by third party.", "populationDescription": "The intent-to-treat (ITT) population included randomized participants from both 52 weeks treatment duration portion and variable treatment duration portion.", "reportingStatus": "POSTED", "paramType": "NUMBER", "dispersionType": "95% Confidence Interval", "unitOfMeasure": "exacerbation per participant-year", "timeFrame": "Baseline (Day 1) up to Week 52 for initial randomized participants; Baseline (Day 1) up to Weeks 24 to 52 for additional randomized participants", "groups": [ { "id": "OG000", "title": "Former Smoker Cohort: Placebo", "description": "Participants who were former smokers received placebo matched to itepekimab as SC injection Q2W for up to 52 weeks." }, { "id": "OG001", "title": "Former Smoker Cohort: Itepekimab 300 mg Q4W", "description": "Participants who were former smokers received itepekimab 300 mg as an SC injection Q4W with alternating placebo matched to itepekimab SC injection administration at the 2-week interval between active study treatment for up to 52 weeks." }, { "id": "OG002", "title": "Former Smoker Cohort: Itepekimab 300 mg Q2W", "description": "Participants who were former smokers received itepekimab 300 mg as an SC injection Q2W for up to 52 weeks." } ], "denoms": [ { "units": "Participants", "counts": [ { "groupId": "OG000", "value": "324" }, { "groupId": "OG001", "value": "303" }, { "groupId": "OG002", "value": "326" } ] } ], "classes": [ { "categories": [ { "measurements": [ { "groupId": "OG000", "value": "0.879", "spread": "0.732", "lowerLimit": "0.732", "upperLimit": "1.054" }, { "groupId": "OG001", "value": "0.770", "spread": "0.636", "lowerLimit": "0.636", "upperLimit": "0.932" }, { "groupId": "OG002", "value": "0.865", "spread": "0.721", "lowerLimit": "0.721", "upperLimit": "1.037" } ] } ] } ], "analyses": [ { "groupIds": [ "OG000", "OG001" ], "groupDescription": "Derived from negative binomial regression model with total number of events occurring during observation duration as response variable, treatment group,eosinophil randomization strata,controller therapy randomization strata,region,number of severe AECOPD events experienced in previous year(0 vs 1+) at baseline and post-bronchodilator(y) (post-BD) forced expiratory volume in one second(FEV1) percent predicted at baseline as covariates and log-transformed observation duration as offset variable.", "nonInferiorityType": "SUPERIORITY", "nonInferiorityComment": "A hierarchical testing procedure was used to control overall type I error. Primary endpoint was tested at 2-sided significance level of 0.049, after which alpha was split. Endpoint of annualized rate of severe AECOPD was tested based on significance level of 0.02, while remaining 6 secondary efficacy endpoints were tested at significance level of 0.029 for comparison between itepekimab (300 mg Q2W or 300 mg Q4W) and placebo. Testing was performed sequentially in order endpoints are reported.", "pValue": "= 0.2176", "statisticalMethod": "Negative binomial regression model", "paramType": "Rate ratio", "paramValue": "0.876", "ciPctValue": "95", "ciNumSides": "TWO_SIDED", "ciLowerLimit": "0.710", "ciUpperLimit": "1.081" }, { "groupIds": [ "OG000", "OG002" ], "groupDescription": "Derived from negative binomial regression model with the total number of events occurring during the observation duration as response variable, treatment group, eosinophil randomization strata, controller therapy randomization strata, region, number of severe AECOPD events experienced in previous year (0 vs. 1+) at baseline, and post-BD FEV1 percent predicted at baseline as covariates, and the log-transformed observation duration as the offset variable.", "nonInferiorityType": "SUPERIORITY", "nonInferiorityComment": "A hierarchical testing procedure was used to control overall type I error. Primary endpoint was tested at 2-sided significance level of 0.049, after which alpha was split. Endpoint of annualized rate of severe AECOPD was tested based on significance level of 0.02, while remaining 6 secondary efficacy endpoints were tested at significance level of 0.029 for comparison between itepekimab (300 mg Q2W or 300 mg Q4W) and placebo. Testing was performed sequentially in order endpoints are reported.", "pValue": "= 0.8781", "statisticalMethod": "Negative binomial regression model", "paramType": "Rate ratio", "paramValue": "0.984", "ciPctValue": "95", "ciNumSides": "TWO_SIDED", "ciLowerLimit": "0.803", "ciUpperLimit": "1.206" } ] } ], "eligibilityCriteria": "Inclusion criteria :\n\n* Participant must be 40 to 85 years of age inclusive.\n* Physician diagnosis of COPD for at least 1 year (based on Global Initiative for Chronic Obstructive Lung Disease \\[GOLD\\] definition).\n* Smoking history of ≥10 pack-years:\n\n * For former smokers: participants who reported that they were not currently smoking and smoking cessation must had occurred ≥6 months prior to Screening (Visit 1A) with an intention to quit permanently.\n * For current smokers: participants who reported that they were currently smoking tobacco (participant smoked at least 1 cigarette per day on average during the past 7 days) at Screening (Visit 1A) and who were not currently participating in or planning to initiate a smoking cessation intervention at Screening (Visit 1A) or during Screening period.\n* Participants with moderate-to-severe COPD\n* Participant-reported history of signs and symptoms of chronic bronchitis (chronic productive cough for at least 3 months in the year prior to Screening in a participant in whom other causes of chronic cough \\[eg, inadequately treated gastroesophageal reflux or chronic rhinosinusitis; or clinical diagnosis of bronchiectasis\\] had been excluded).\n* Documented history of high exacerbation risk defined as having had ≥2 moderate or ≥1 severe exacerbations within the year prior to Screening (Visit 1A), with at least 1 exacerbation treated with systemic corticosteroids. At least one exacerbation must had occurred while participants were on their current controller therapy:\n\n * Moderate exacerbations would be recorded by the Investigator and were defined as acute worsening of respiratory symptoms that requires either systemic corticosteroids (IM, IV, or oral) and/or antibiotics.\n * Severe exacerbations would be recorded by the Investigator and were defined as AECOPD that required hospitalization or observation for \\>24 hours in emergency department/urgent care facility.\n* Participants with standard of care controller therapy, for ≥3 months prior to Screening (Visit 1A) and at a stable dose of controller therapy for at least 1 month prior to the Screening, including either: inhaled corticosteroid (ICS) + long-acting beta-agonist (LABA), long-acting muscarinic antagonist (LAMA) + LABA or LAMA + LABA + ICS.\n* Body mass index (BMI) ≥18.0 kg/m\\^2, or BMI ≥16.0 kg/m\\^2 for participants enrolled in East-Asian countries.\n* Female participant was not pregnant, not breastfeeding, and at least one of the following conditions applies:\n\n * not a women of child-bearing potential (WOCBP) OR\n * a WOCBP who agreed to follow the contraceptive guidance during the intervention period and for at least 20 weeks after the last dose of study intervention. -\n\nExclusion criteria:\n\n* Current diagnosis of asthma according to the Global Initiative for Asthma (GINA) guidelines, or documented history of asthma unless asthma resolved before 18 years of age and has not recurred.\n* For former smokers: Active smoking or vaping of any products (eg, nicotine, tetrahydrocannabinol \\[THC\\]) within 6 months prior to Screening (Visit 1A).\n* For current smokers: vaping of any products (eg, nicotine, THC) within 6 months prior to Screening (Visit 1A).\n* Clinically significant new abnormal electrocardiogram (ECG) within 6 months prior to, or at Screening (Visit 1A) that might affect the participant's participation in the study.\n* Clinically significant and current pulmonary disease other than COPD, eg, sarcoidosis, interstitial lung disease, bronchiectasis (clinical diagnosis), diagnosis of α-1 anti-trypsin deficiency, or another diagnosed pulmonary disease.\n* Diagnosis of cor pulmonale, evidence of right cardiac failure, or moderate-to-severe pulmonary hypertension.\n* Hypercapnia requiring bilevel positive airway pressure (BiPAP).\n* Moderate or severe exacerbation of COPD (AECOPD) within 4 weeks prior to Screening (Visit 1A).\n* Prior history of / planned: lung pneumonectomy for any reason, or lung volume reduction procedures (including bronchoscopic volume reduction) for COPD. Note: Surgical biopsy, or segmentectomy, or wedge resection, or lobectomy for other diseases would not be excluded.\n* Unstable ischemic heart disease, including acute myocardial infarction within the past 1 year prior to Screening, or unstable angina in the 6 months prior to Screening (Visit 1A).\n* Cardiac arrhythmias including paroxysmal (eg, intermittent) atrial fibrillation.\n* Uncontrolled hypertension (ie, systolic blood pressure \\[BP\\] \\>180 mm Hg or diastolic BP \\>110 mm Hg with or without use of anti-hypertensive therapy).\n* Participants with active tuberculosis (TB), latent TB, a history of incompletely treated TB, suspected extrapulmonary TB infection (TBI), or who were at high risk of contracting TB (such as close contact with individuals with active or latent TB) or received Bacillus Calmette-Guérin (BCG)-vaccination within 12 weeks prior to Screening (Visit 1A).\n* History of human immunodeficiency virus (HIV) infection or positive HIV 1/2 serology at Screening (Visit 1A).\n* Suspicion of, or confirmed, coronavirus disease 2019 (COVID-19) infection or in contact with known exposure to COVID-19 at Screening (Visit 1A); known history of COVID-19 infection within 4 weeks prior to Screening (Visit 1A); history of requiring mechanical ventilation or extracorporeal membrane oxygenation (ECMO) secondary to COVID-19 within 3 months prior to Screening (Visit 1A); participants who have had a COVID-19 infection prior Screening (Visit 1A) who had not yet sufficiently recovered to participate in the procedures of a clinical trial.\n* Evidence of acute or chronic infection requiring systemic treatment with antibacterial, antiviral, antifungal, antiparasitic, or antiprotozoal medications within 4 weeks before Screening (Visit 1A), significant viral infections within 4 weeks before Screening (Visit 1A) that might not have been treated with antiviral treatment (eg, influenza receiving only symptomatic treatment).\n* Participants with active autoimmune disease or participants using immunosuppressive therapy for autoimmune disease (eg, rheumatoid arthritis, inflammatory bowel disease, primary biliary cirrhosis, systemic lupus erythematosus, multiple sclerosis.\n* History of malignancy within 5 years before Screening (Visit 1A), except completely treated in situ carcinoma of the cervix, completely treated and resolved nonmetastatic squamous or basal cell carcinoma of the skin.\n* Previous use of itepekimab.\n\nThe above information was not intended to contain all considerations relevant to a participant's potential participation in a clinical trial." }, "NCT04786171": { "title": "4D Medical X-ray Velocimetry for Bronchoscopic Lung Volume Reduction Targeting", "status": "COMPLETED", "lastUpdate": "2024-06-21", "hasResults": false, "resultsFirstPost": null, "statusModule": { "statusVerifiedDate": "2024-06", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2021-01-07", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2024-05-30", "type": "ACTUAL" }, "completionDateStruct": { "date": "2024-05-30", "type": "ACTUAL" }, "studyFirstSubmitDate": "2021-03-03", "studyFirstSubmitQcDate": "2021-03-03", "studyFirstPostDateStruct": { "date": "2021-03-08", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2024-06-18", "lastUpdatePostDateStruct": { "date": "2024-06-21", "type": "ACTUAL" } }, "results_sha256": null }, "NCT05037929": { "title": "A Study to Evaluate the Efficacy and Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Disease", "status": "COMPLETED", "lastUpdate": "2026-10-16", "hasResults": true, "resultsFirstPost": "2026-10-16", "statusModule": { "statusVerifiedDate": "2026-09", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2021-10-05", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2025-02-24", "type": "ACTUAL" }, "completionDateStruct": { "date": "2025-07-07", "type": "ACTUAL" }, "studyFirstSubmitDate": "2021-08-31", "studyFirstSubmitQcDate": "2021-08-31", "studyFirstPostDateStruct": { "date": "2021-09-08", "type": "ACTUAL" }, "resultsFirstSubmitDate": "2026-07-07", "resultsFirstSubmitQcDate": "2026-09-24", "resultsFirstPostDateStruct": { "date": "2026-10-16", "type": "ACTUAL" }, "dispFirstSubmitDate": "2026-02-23", "dispFirstPostDateStruct": { "date": "2026-10-16", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-09-24", "lastUpdatePostDateStruct": { "date": "2026-10-16", "type": "ACTUAL" } }, "results_sha256": "0637e7ba0feedf4a95509b51e978717427082806affe918127d51577c988003b" }, "NCT05158387": { "title": "Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.", "status": "COMPLETED", "lastUpdate": "2026-04-16", "hasResults": false, "resultsFirstPost": null, "statusModule": { "statusVerifiedDate": "2026-04", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2022-02-07", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2026-01-19", "type": "ACTUAL" }, "completionDateStruct": { "date": "2026-03-22", "type": "ACTUAL" }, "studyFirstSubmitDate": "2021-12-02", "studyFirstSubmitQcDate": "2021-12-02", "studyFirstPostDateStruct": { "date": "2021-12-15", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-04-15", "lastUpdatePostDateStruct": { "date": "2026-04-16", "type": "ACTUAL" } }, "results_sha256": null }, "NCT05166889": { "title": "Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations", "status": "COMPLETED", "lastUpdate": "2026-04-16", "hasResults": false, "resultsFirstPost": null, "statusModule": { "statusVerifiedDate": "2026-04", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2022-01-03", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2026-01-19", "type": "ACTUAL" }, "completionDateStruct": { "date": "2026-03-11", "type": "ACTUAL" }, "studyFirstSubmitDate": "2021-12-09", "studyFirstSubmitQcDate": "2021-12-09", "studyFirstPostDateStruct": { "date": "2021-12-22", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-04-15", "lastUpdatePostDateStruct": { "date": "2026-04-16", "type": "ACTUAL" } }, "results_sha256": null }, "NCT05270525": { "title": "Effect of Ensifentrine on Sputum Markers of Inflammation in COPD", "status": "ACTIVE_NOT_RECRUITING", "lastUpdate": "2026-09-30", "hasResults": false, "resultsFirstPost": null, "statusModule": { "statusVerifiedDate": "2026-09", "overallStatus": "ACTIVE_NOT_RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2022-05-27", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2027-03-01", "type": "ESTIMATED" }, "completionDateStruct": { "date": "2027-03-01", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2022-02-08", "studyFirstSubmitQcDate": "2022-02-22", "studyFirstPostDateStruct": { "date": "2022-03-08", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-09-25", "lastUpdatePostDateStruct": { "date": "2026-09-30", "type": "ACTUAL" } }, "results_sha256": null }, "NCT05595642": { "title": "A Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease", "status": "ACTIVE_NOT_RECRUITING", "lastUpdate": "2026-05-20", "hasResults": false, "resultsFirstPost": null, "statusModule": { "statusVerifiedDate": "2026-05", "overallStatus": "ACTIVE_NOT_RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2022-12-29", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2025-06-24", "type": "ACTUAL" }, "completionDateStruct": { "date": "2027-09-24", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2022-10-24", "studyFirstSubmitQcDate": "2022-10-24", "studyFirstPostDateStruct": { "date": "2022-10-27", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-05-19", "lastUpdatePostDateStruct": { "date": "2026-05-20", "type": "ACTUAL" } }, "results_sha256": null }, "NCT05743075": { "title": "A Study to Evaluate the Efficacy and Safety of Ensifentrine for 24 Weeks in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease", "status": "COMPLETED", "lastUpdate": "2025-06-04", "hasResults": false, "resultsFirstPost": null, "statusModule": { "statusVerifiedDate": "2025-05", "overallStatus": "COMPLETED", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2023-03-10", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2024-12-06", "type": "ACTUAL" }, "completionDateStruct": { "date": "2025-03-07", "type": "ACTUAL" }, "studyFirstSubmitDate": "2023-02-14", "studyFirstSubmitQcDate": "2023-02-14", "studyFirstPostDateStruct": { "date": "2023-02-24", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2025-05-29", "lastUpdatePostDateStruct": { "date": "2025-06-04", "type": "ACTUAL" } }, "results_sha256": null }, "NCT05775588": { "title": "Long-term Effects of Endobronchial Valve Implantation on Cardiac Function and Skeletal Muscle Function", "status": "RECRUITING", "lastUpdate": "2026-10-05", "hasResults": false, "resultsFirstPost": null, "statusModule": { "statusVerifiedDate": "2026-09", "overallStatus": "RECRUITING", "expandedAccessInfo": { "hasExpandedAccess": false }, "startDateStruct": { "date": "2023-03-27", "type": "ACTUAL" }, "primaryCompletionDateStruct": { "date": "2028-12-31", "type": "ESTIMATED" }, "completionDateStruct": { "date": "2029-12-31", "type": "ESTIMATED" }, "studyFirstSubmitDate": "2023-02-23", "studyFirstSubmitQcDate": "2023-03-16", "studyFirstPostDateStruct": { "date": "2023-03-20", "type": "ACTUAL" }, "lastUpdateSubmitDate": "2026-09-30", "lastUpdatePostDateStruct": { "date": "2026-10-05", "type": "ACTUAL" } }, "results_sha256": null }, "NCT06335992": { "title": "Tissue 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However, no head-to-head trials or real-world comparative effectiveness studies have been reported. We aimed to compare the effectiveness of dupilumab, mepolizumab, and benralizumab in patients with COPD using propensity score-matched cohort analyses.", "Retrospective cohort study using the TriNetX US Collaborative Network.", "Adults with COPD initiating dupilumab, mepolizumab, or benralizumab between 2022 and 2025 were identified. Biologic-naive new users were included in two pairwise comparisons: dupilumab versus mepolizumab and dupilumab versus benralizumab. Propensity score matching (1:1) balanced baseline characteristics. The primary outcome was COPD exacerbation; secondary outcomes included acute respiratory failure, pneumonia, and bronchitis over 365 days. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards models.", "Propensity score matching identified 3078 dupilumab-mepolizumab pairs and 2109 dupilumab-benralizumab pairs. Compared with mepolizumab, dupilumab was associated with a numerically lower risk of COPD exacerbation (HR, 0.76; 95% CI, 0.57-1.01) and a significantly lower risk of bronchitis (HR, 0.69; 95% CI, 0.49-0.98). No significant differences were observed between dupilumab and benralizumab for COPD exacerbation (HR, 0.98; 95% CI, 0.70-1.40), acute respiratory failure, pneumonia, or bronchitis.", "In this large real-world cohort study, no statistically significant difference in COPD exacerbation risk was observed between dupilumab and mepolizumab or between dupilumab and benralizumab. However, blood eosinophil counts and baseline lung function measurements were not available in the dataset, so residual confounding cannot be excluded." ], "pubmed_publication_types": [ "Journal Article", "Comparative Study" ], "live_efetch_endpoint": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&retmode=xml&id=42928777" }, "42928880": { "title": "CONQUEST-ADVANCE: Achieving proDuctiVe implementAtioN of CONQUEST Quality Standards in COPD Care.", "identifiers": { "pubmed": "42928880", "pmc": "PMC13695919", "doi": "10.2147/POR.S601059", "pii": "601059" }, "journal": "Pragmat Obs Res", "abstract": [ "Integrated COPD management has improved outcomes for patients with diagnosed COPD. The CONQUEST Quality Improvement Program aims to improve the diagnosis and management for patients with potential and diagnosed modifiable high-risk (MHR) COPD, defined as those with a history of exacerbations and opportunities for treatment optimization.", "Utilizing the CONQUEST registry and Optimum Patient Care (OPC) Research Database, this observational cohort analysis assessed changes in quality indicator attainment over 12 months among potentially undiagnosed, newly diagnosed and already diagnosed patients with MHR COPD in exposed and matched usual care (UC) general practices. In exposed practices, newly diagnosed and already diagnosed patients were restricted to those receiving OPC-led CONQUEST clinics. Outcomes were compared using difference-in-difference generalized linear models with overlap propensity weighting.", "From 168 UK practices, we identified 113,574 potentially undiagnosed (59,706 exposed, 53,868 UC), 2787 newly diagnosed (1448 exposed of which 252 attended OPC clinics, 1339 UC) and 38,054 already diagnosed (21,670 exposed of which 392 attended OPC clinics, 16,384 UC). Potentially undiagnosed patients in exposed practices were more likely to subsequently receive a spirometry-confirmed COPD diagnosis (1.0% vs 0.6%; adjusted ratios-of-risk-ratios [ARRR]:1.55, 95% CI: 1.19-2.01) compared to UC. Initiation or step-up to guideline-appropriate inhaled therapy was more likely among OPC-supported patients in exposed practices for newly diagnosed (96.4% vs 55.7%; ARRR: 1.71, 95% CI: 1.41-2.06) and already diagnosed (91.6% vs 39.8%; ARRR: 1.94, 95% CI: 1.77-2.1212) versus unsupported UC.", "CONQUEST is associated with measurable improvements in quality indicator attainment aligned with guideline-recommended identification and management of COPD, including higher rates of spirometry-confirmed COPD diagnosis and treatment optimization. Future randomized trials will evaluate if this translates into improved outcomes including reduced exacerbations and hospitalizations." ], "pubmed_publication_types": [ "Journal Article" ], "live_efetch_endpoint": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&retmode=xml&id=42928880" }, "42897575": { "title": "Needs among persons with advanced COPD and their informal caregivers: a multi-perspective qualitative study focusing on the potential role of palliative care.", "identifiers": { "pubmed": "42897575", "pmc": "PMC13681904", "doi": "10.1186/s12890-026-04828-5", "pii": "10.1186/s12890-026-04828-5" }, "journal": "BMC Pulm Med", "abstract": [ "To explore needs among persons with advanced COPD and informal caregivers, and to explore how palliative care can address those needs.", "COPD is a common, progressive disease affecting lung function and represents a leading cause of death. Advanced COPD is associated with a high symptom burden and poor quality of life. Persons with advanced COPD may benefit from palliative care, but its use among persons with COPD remains limited, also in Germany.", "A qualitative, multi-perspective interview study was conducted with persons suffering from advanced COPD, informal caregivers, and formal caregivers (general practitioners, pulmonologists, and palliative care physicians). A total of 53 interviews were analysed following structuring (Kuckartz') as well as latent content analysis methods using MAXQDA.", "Key needs were identified in the following domains (1) management of dyspnoea and anxiety, (2) home-based healthcare, (3) emergency planning and support, (4) psychosocial care, (5) organisational support, and (6) timely information about COPD and palliative care. Persons who had previously received PC reported various needs met in the first five areas.", "Persons with advanced COPD and their informal caregivers reported numerous needs. Persons receiving palliative care reported relief from various needs. Timely information about COPD's progression and palliative care could increase acceptance and thus use of palliative care among these persons and could consequently reduce or curtail the burden of living with advanced COPD." ], "pubmed_publication_types": [ "Journal Article" ], "live_efetch_endpoint": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&retmode=xml&id=42897575" }, "42899053": { "title": "Effect of l-menthol on breathlessness and exercise endurance in COPD: a randomised crossover trial.", "identifiers": { "pubmed": "42899053", "pmc": "PMC13678658", "doi": "10.1183/23120541.00495-2026", "pii": "00495-2026" }, "journal": "ERJ Open Res", "abstract": [ "Breathlessness is a leading cause of disability and reduced quality of life in COPD. Inhaled l-menthol may reduce breathlessness but data on its effect on exertional breathlessness is limited. We aimed to evaluate the effect of inhaled l-menthol on exertional breathlessness and exercise capacity in patients with COPD.", "This was a double-blinded, randomised (ratio 1:1), crossover trial (RCT) of l-menthol inhalation versus placebo. 20 participants with COPD performed two constant-load cycle cardiopulmonary exercise tests (CPET) to exhaustion, with either l-menthol or placebo (strawberry) scented patch in the mask in randomised order. The primary outcome was the difference in breathlessness intensity (Borg 0-10 scale) at isotime. Secondary outcomes were change in breathlessness unpleasantness and leg fatigue at isotime, exercise endurance time (EET), exertional physiological responses and multidimensional breathlessness (MDP).", "Compared with placebo, inhaled l-menthol reduced breathlessness intensity at isotime (mean difference -0.8, 95% CI -1.6-0.0; p=0.042), corresponding to a moderate effect size (Cohen's d= -0.49). Isotime breathlessness unpleasantness (-0.7, -1.7-0.3) and emotional response score was lower with L-menthol (-2.2, -4.4-0.0). Leg discomfort (-0.5, -1.3-0.2) was numerically lower, EET was longer (0.9 min, -0.7-2.5) and physiological responses were unchanged.", "Inhalation of l-menthol reduced the intensity and emotional response of exertional breathlessness and increased the EET compared with placebo in patients with COPD. The unchanged physiological responses support a central brain effect and l-menthol might be a promising new treatment." ], "pubmed_publication_types": [ "Journal Article" ], "live_efetch_endpoint": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&retmode=xml&id=42899053" }, "42905895": { "title": "Comparison of Nebulized Long-Acting Muscarinic Antagonist Revefenacin to Ipratropium in COPD Patients With Acute Respiratory Failure Requiring Mechanical Ventilation: Results of the RARICO Study.", "identifiers": { "pubmed": "42905895", "doi": "10.15326/jcopdf.2026.0804" }, "journal": "Chronic Obstr Pulm Dis", "abstract": [ "Revefenacin is a nebulized long-acting muscarinic antagonist approved for maintenance therapy in stable chronic obstructive pulmonary disease (COPD). We conducted a pilot study to evaluate the feasibility and safety of revefenacin in mechanically ventilated COPD patients with acute respiratory failure (ARF), and compare its use with the short-acting muscarinic antagonist ipratropium, the current standard inpatient therapy.", "In this double-blind, randomized controlled pilot study, intubated COPD patients were assigned to revefenacin 175mcg once daily plus three placebo doses, or ipratropium 500mcg via vibrating mesh nebulizer every 6 hours, for up to 7 days. The primary endpoints were safety and feasibility; exploratory endpoints included ventilator-derived respiratory mechanics and clinical outcomes.", "Twenty-one patients (mean age 76±11 years, 60±51 pack years smoking, percent-predicted FEV1 56±26%) were randomized to revefenacin (N=12) or ipratropium (N=9). Duration of mechanical ventilation was similar between groups (2.5±2.3 vs 3.6±2.8 days; P=0.83), with similar number of administered doses (2.8±2.1 vs 14.2±11.1; P=0.74). Daily nebulization time was significantly lower with revefenacin (7.2±1.0 vs 26.8±5.3 minutes; P<0.01). Adverse events were infrequent and comparable between the groups. Revefenacin improved dynamic resistance (Rdyn) post-dose (-0.9 vs +2.6 cmH₂O/L/s; P<0.01), without differences in peak inspiratory, resistive, or plateau pressures.", "Once-daily nebulized revefenacin is a feasible and safe alternative to ipratropium in mechanically ventilated COPD patients with ARF, with reduced time spent on nebulization adminitration. Improvements in airway resistance suggest a potential physiologic benefit, warranting further investigation." ], "pubmed_publication_types": [ "Journal Article" ], "live_efetch_endpoint": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&retmode=xml&id=42905895" }, "42933872": { "title": "[Chinese guidelines for the diagnosis and management of chronic obstructive pulmonary disease (2026 revision)].", "identifiers": { "pubmed": "42933872", "doi": "10.3760/cma.j.cn112147-20260817-00487" }, "journal": "Zhonghua Jie He He Hu Xi Za Zhi", "abstract": [ "The Chinese guidelines for the diagnosis and management of chronic obstructive pulmonary disease (2026 revision) were developed by the Chronic Obstructive Pulmonary Disease Groups of the Chinese Thoracic Society and the Chinese Association of Chest Physicians. Building on the 2021 edition, this revision incorporates evidence published over the past five years and experience from COPD prevention and management in China, and provides comprehensive updates on disease definition, etiology and pathogenesis, case finding, diagnosis and comprehensive assessment, stable COPD management, diagnosis and treatment of acute exacerbations, comorbidity management, and future research directions. The guideline primarily applies the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, supplemented by the Oxford Centre for Evidence-Based Medicine Levels of Evidence, to assess the certainty of evidence and develop recommendations. It offers practical recommendations for the diagnosis and management of COPD across 22 clinical questions. It aims to promote early identification, standardized diagnosis and treatment, and comprehensive management of COPD, and therefore to improve the standardized care and reduce the disease burden of COPD in China.The 22 key clinical questions and corresponding recommendations are summarized as follows.Question 1: Given the current underdiagnosis of COPD, which strategies can improve early diagnosis?Recommendation 1: We recommend active and opportunistic case finding to identify individuals at high risk of COPD and facilitate early diagnosis. (1B/strong recommendation)Question 2: Which parameters should be assessed when selecting initial pharmacotherapy for patients with COPD?Recommendation 2: Patients with COPD should undergo individualized assessment based on symptom burden and exacerbation risk and be classified into groups A, B, or E. Additional assessments should include the severity of airflow obstruction on pulmonary function testing, comorbidities, and biomarkers such as the peripheral blood eosinophil count. (2B/strong recommendation)Question 3: How should the mMRC and CAT scores be used for symptom assessment in the ABE classification?Recommendation 3: Symptoms of COPD should be assessed using the modified Medical Research Council (mMRC) dyspnea scale and/or the COPD Assessment Test (CAT). Results from the two instruments may be discordant: the mMRC scale focuses on dyspnea, whereas the CAT is more suitable for a comprehensive assessment of multiple symptoms. (2B/strong recommendation)Question 4: Should chest CT be included in the initial assessment of COPD?Recommendation 4: Chest imaging should be included in the initial assessment of COPD, with chest computed tomography (CT) preferred. (2B/conditional recommendation)Question 5: What are the key preventive measures targeting exposure to risk factors?Recommendation 5: Smoking cessation interventions should be actively provided to all patients with COPD. Clean fuels, effective ventilation, nonpolluting stoves, and similar measures are recommended to reduce harmful environmental exposures; occupational protection should also be strengthened to avoid continued exposure to potential irritants. (1A/strong recommendation)Question 6: How should vaccination be recommended for patients with COPD?Recommendation 6: Annual influenza vaccination is recommended. Regular pneumococcal vaccination with PPSV23 is also recommended, with PCV20 or PCV21 as options for susceptible individuals; the specific pneumococcal vaccination schedule should follow product-specific prescribing information. (1A/strong recommendation). Vaccination against respiratory syncytial virus (RSV), tetanus, diphtheria, and acellular pertussis (Tdap), and herpes zoster is suggested. (1A/conditional recommendation)Question 7: How should initial pharmacotherapy be selected according to the ABE classification and the peripheral blood eosinophil count?Recommendation 7: Initial pharmacotherapy should be selected according to symptoms, exacerbation risk, and the peripheral blood eosinophil count. For patients in group E, regimens that reduce the risk of future exacerbations should be prioritized. When the peripheral blood eosinophil count is ≥300 cells/μl, triple inhaled therapy[inhaled corticosteroids(ICS) plus long-acting β2 agonists (LABA) plus long-acting muscarinic antagonists(LAMA)] is recommended to achieve a state of low disease activity characterized by freedom from exacerbations. (1B/strong recommendation)Question 8: What are the indications for adding an ICS to long-acting bronchodilator therapy?Recommendation 8: The addition of an ICS to long-acting bronchodilator therapy is recommended for patients with COPD who have any of the following features: (1)≥1 moderate or severe COPD exacerbation per year; (2) a blood eosinophil count ≥300 cells/μl, or ≥100 cells/μl during follow-up assessment; or (3) a history of asthma or concomitant asthma-like features. (1B/strong recommendation)Question 9: How should a standardized pathway for follow-up assessment and pharmacological treatment adjustment be established for patients with stable COPD?Recommendation 9: During follow-up pharmacotherapy, treatment adjustment should be guided by two core treatable traits: persistent dyspnea and the occurrence of exacerbations. For patients with persistently poor symptom control, bronchodilator therapy should be optimized stepwise after inhaler technique, adherence, and the effects of comorbidities have been assessed. For patients who continue to experience exacerbations, the addition, continuation, or cautious withdrawal of ICS should be guided by the current regimen and peripheral blood eosinophil count. Biologic therapy is appropriate for selected high-risk populations. (1B/strong recommendation)Question 10: How should treatment be optimized and adjusted for patients already receiving ICS+LABA therapy?Recommendation 10: Patients receiving ICS+LABA may continue the regimen if their condition is stable. If exacerbations persist, escalation to triple therapy with ICS+LABA+LAMA is recommended. For patients with COPD who are at high risk of pulmonary infection, including mycobacterial infection, withdrawal of ICS and a switch to dual bronchodilator therapy should be considered to reduce the risk of further infections. (1B/strong recommendation)Question 11: What are the indications for biologic therapy in patients with COPD?Recommendation 11: For patients who continue to experience recurrent exacerbations despite ICS+LABA+LAMA therapy, inhaled medication use, comorbidities and other contributing factors should be assessed, and biologic therapy should be selected on an individualized basis according to features such as the peripheral blood eosinophil count and the presence of chronic bronchitis. (1B/conditional recommendation)Question 12: How should an inhaler device be selected according to individual patient characteristics?Recommendation 12: The most appropriate inhaler device and medication should be selected according to whether the patient has adequate inspiratory flow, hand-mouth coordination, and the ability to inhale independently, as well as the characteristics of the device and medication. Training in inhaler technique and individualized assessment should be reinforced. (4/strong recommendation)Question 13: How should pulmonary rehabilitation be implemented for patients with COPD?Recommendation 13: Dynamic pulmonary rehabilitation assessment is recommended before treatment and at different stages during treatment, including clinical, functional, nutritional, and psychological assessments. Pulmonary rehabilitation should be initiated as early as possible in patients with stable COPD who have no absolute contraindications. For patients with acute exacerbations of COPD, pulmonary rehabilitation should be provided early during hospitalization and after discharge. An individualized rehabilitation prescription should be developed according to assessment findings and may include airway clearance techniques, breathing training, aerobic and resistance exercise, positioning, and respiratory support. (1A/strong recommendation)Question 14: What are the indications and treatment regimen for oxygen therapy in stable COPD?Recommendation 14: Long-term oxygen therapy is recommended for patients with COPD and severe resting hypoxemia, defined as either (1) PaO2≤55 mmHg(1 mmHg=0.133 kPa) or SpO2≤88% at rest, or (2) PaO2 of 55-60 mmHg or SpO2 of 88%-89% at rest together with pulmonary hypertension, peripheral edema suggestive of congestive heart failure, or polycythemia (hematocrit>55%). Oxygen should be administered for at least 15 h/day to maintain PaO2 ≥60 mmHg and/or SpO2 ≥90%. (1B/strong recommendation)Question 15: What are the indications for noninvasive ventilation in stable COPD?Recommendation 15: Long-term noninvasive ventilation (NIV) is suggested for patients with severe chronic hypercapnia and a history of hospitalization for acute respiratory failure, or for those with persistent daytime hypercapnia (PaCO2>53 mmHg). (1B/strong recommendation)Question 16: Which pharmacological and nonpharmacological interventions can reduce mortality in patients with COPD?Recommendation 16: Smoking cessation, pharmacotherapy (fixed-dose triple therapy), and nonpharmacological interventions, including pulmonary rehabilitation, long-term oxygen therapy, noninvasive ventilation, and surgical lung volume reduction, are recommended to reduce mortality in patients with COPD. (1B/strong recommendation)Question 17: How should bronchoscopic interventional therapies be selected for patients with COPD?Recommendation 17: Bronchoscopic interventions, including endobronchial valves and thermal vapor ablation, are recommended for selected patients with advanced emphysema and COPD. (1B/conditional recommendation)Question 18: What are the indications for lung transplantation in patients with COPD?Recommendation 18: For patients with very severe COPD (progressive disease with a BODE index of 7-10 who are not candidates for lung volume reduction surgery), referral for lung transplantation may be considered if at least one of the following is present: (1) a history of hospitalization for an acute hypercapnic exacerbation (PaCO2>50 mmHg); (2) pulmonary hypertension and/or cor pulmonale despite oxygen therapy; or (3) FEV₁<20% predicted together with DLCO<20% predicted or homogeneous emphysema. (3B/conditional recommendation)Question 19: How should systemic corticosteroids be used for acute exacerbations of COPD?Recommendation 19: For moderate or severe acute exacerbations of COPD, low-dose, short-course systemic corticosteroid therapy is suggested; routine prolongation of treatment or use of high-dose systemic corticosteroids is not recommended. Nebulized budesonide may be considered as an alternative for patients with contraindications to systemic corticosteroids or a high risk of adverse reactions. (Very low-quality evidence/weak recommendation)Question 20: How should high-flow nasal cannula oxygen therapy be used in the treatment of acute exacerbations of COPD?Recommendation 20: High-flow nasal cannula (HFNC) oxygen therapy is suggested for patients with an acute exacerbation of COPD who have persistent hypoxemia, cannot tolerate NIV or have contraindications to NIV, require sequential oxygen therapy after NIV, or require prevention of reintubation after extubation. In patients with acute hypercapnic respiratory failure who meet the indications for NIV, HFNC should not replace NIV as the preferred initial treatment. (1B/conditional recommendation)Question 21: What are the indications for noninvasive ventilation in the treatment of acute exacerbations of COPD?Recommendation 21: NIV is recommended for patients with an acute exacerbation of COPD who have any of the following: (1) respiratory acidosis (PaCO2 ≥6.0 kPa or 45 mmHg and arterial pH≤7.35); (2) severe dyspnea with clinical signs of respiratory muscle fatigue and/or increased work of breathing, such as use of accessory respiratory muscles, paradoxical thoracoabdominal motion, or intercostal retraction; (3) persistent hypoxemia despite oxygen therapy; or (4) a need for sequential invasive-noninvasive mechanical ventilation. (1A/strong recommendation)Question 22: What measures are recommended to prevent acute exacerbations of COPD?Recommendation 22: After an acute exacerbation, the management plans for COPD and its comorbidities should be evaluated, and appropriate measures should be implemented to prevent further exacerbations, particularly peri-discharge management, long-term standardized pharmacotherapy, smoking cessation, vaccination, and nonpharmacological interventions such as pulmonary rehabilitation. (4/strong recommendation).", "《慢性阻塞性肺疾病诊治指南（2026年修订版）》由中华医学会呼吸病学分会慢性阻塞性肺疾病（简称慢阻肺病）学组和中国医师协会呼吸医师分会慢阻肺病学组组织制订。在2021年版指南基础上，本次修订结合近5年国内外循证医学证据和我国慢阻肺病防治实践，对疾病定义、病因与发病机制、病例发现、诊断与综合评估、稳定期管理、急性加重诊治、共病管理及未来研究方向进行了全面更新。指南主要采用GRADE方法，并结合牛津循证医学中心证据分级体系，对证据质量进行评价并形成推荐意见，围绕22个临床问题提出可操作的诊疗建议。指南旨在促进我国慢阻肺病的早期识别、规范诊疗和全程管理，提高我国慢阻肺病诊疗规范化水平，降低疾病负担。." ], "pubmed_publication_types": [ "English Abstract", "Journal Article" ], "live_efetch_endpoint": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&retmode=xml&id=42933872" }, "42933817": { "title": "Nationwide study of blood eosinophils in COPD: impact of exacerbations and corticosteroids.", "identifiers": { "pubmed": "42933817", "doi": "10.1136/bmjresp-2026-004269", "pii": "13/1/e004269" }, "journal": "BMJ Open Respir Res", "abstract": [], "pubmed_publication_types": [ "Journal Article" ], "live_efetch_endpoint": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&retmode=xml&id=42933817" } }, "full_text_checks": { "42928777": { "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13695899/fullTextXML", "claim_locations": [ "Table 1: matched cohorts 3078 and 2109 pairs", "Table 2: exacerbation HR 0.76 (0.57–1.01), 0.98 (0.70–1.40)", "Study Design and Patient Population: diagnosis-code algorithm includes asthma–COPD overlap and off-label use", "Conclusions: missing eosinophils/lung-function data, residual confounding" ], "quotation": "These findings are hypothesis-generating and do not support a preference for one biologic over another." }, "42928880": { "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13695919/fullTextXML", "claim_locations": [ "Results", "Limitations: exposed diagnosed cohorts restricted to clinic attendees", "Conclusion: clinical outcomes reserved for PREVAIL" ], "quotation": "residual confounding is possible." }, "42897575": { "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13681904/fullTextXML", "claim_locations": [ "Table 1: 17 patients, 10 informal caregivers", "Table 2: 10 GPs, 9 pulmonologists, 7 palliative physicians", "Table 3: six needs domains", "Limitations: physician recruitment and German system transferability" ], "quotation": "findings of this study were not returned to participants for validation." }, "42899053": { "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13678658/fullTextXML", "claim_locations": [ "Table 1: 20 participants", "Table 3: endurance time difference 0.9 min, 95% CI −0.7 to 2.5", "Strengths and limitations: unblinding and no neutral odour comparator" ], "quotation": "The lack of a neutral no-odour comparator limits interpretation" }, "42905895": { "url": "https://journal.copdfoundation.org/Portals/0/JCOPDF/InPress/JCOPDF-2026-0804-InPress.pdf", "status": "PDF downloaded but not read; 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