{ "condition": "colorectal-adenocarcinoma", "date": "2026-10-26", "engine": "Claude (claude-opus-5-5)", "window": { "from": "2026-08-28", "to": "2026-10-26", "field": "publication date; plus entrez date from 2026-10-19; triage restricted to records not harvested in the 2026-10-19 manifest or already in the bibliography" }, "sources_queried": [ "PubMed E-utilities esearch/esummary/efetch (MCP PubMed tools disconnected; E-utilities used as the live equivalent)", "PubMed \"Cochrane Database Syst Rev\"[jour] per topic", "Europe PMC REST search (full-text availability per candidate; Cochrane journal; SRC CBA/AGR/HIR/CTX/ETH; SRC PPR; non-MEDLINE trial slice; high-signal MED slice)", "Crossref works/{doi} updated-by (no mailto)", "ClinicalTrials.gov API v2 (all 36 tracked NCT IDs + 3 newly cited)", "jRCT jRCTs041230120 (PRABITAS) detail page", "Society pages: NCCN colon and rectal detail pages, USPSTF CRC screening, Leitlinienprogramm Onkologie Kolorektales Karzinom", "Patient organisations: Colorectal Cancer Alliance news + 2026-09-01 press release, Bowel Cancer UK news (HTTP 200, no dated item parsed)" ], "sources_not_queried": [ "Cochrane Library/CENTRAL (HTTP 403 per SOURCES.md; not attempted)", "SciELO/LILACS (HTTP 403 per SOURCES.md; not attempted)", "Unpaywall (LIFEBANK_CONTACT_EMAIL unset)", "WHO ICTRP (JS-driven; not counted)", "ESMO guideline index URL returned HTTP 404", "ACS recommendations page HTTP 406", "Fight Colorectal Cancer news HTTP 403", "Embase/Scopus/WoS (no credentials)" ], "pubmed": [ { "topic": "burden-young-onset", "cochrane": false, "query": "(\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND (epidemiolog* OR incidence OR mortality OR burden OR GLOBOCAN OR GBD OR disparit* OR \"early-onset\" OR \"young-onset\" OR \"early onset\" OR \"birth cohort\") AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date 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(patholog* OR staging OR TNM OR budding OR MMR OR immunohistochemistry OR \"circumferential resection\") AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "(\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"patholog*\"[All Fields] OR (\"stage\"[All Fields] OR \"staged\"[All Fields] OR \"stages\"[All Fields] OR \"staging\"[All Fields] OR \"stagings\"[All Fields]) OR \"TNM\"[All Fields] OR (\"budded\"[All Fields] OR \"budding\"[All Fields] OR \"buddings\"[All Fields]) OR (\"mil med res\"[Journal] OR \"mmr\"[All Fields]) OR (\"immunohistochemistries\"[All Fields] OR \"immunohistochemistry\"[MeSH Terms] OR \"immunohistochemistry\"[All Fields]) OR \"circumferential resection\"[All Fields]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 1753, 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"cochrane": false, "query": "(\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND ((rectal[tiab] OR rectum[tiab]) AND (TNT OR \"total neoadjuvant\" OR \"watch and wait\" OR \"watch-and-wait\" OR \"organ preservation\" OR RAPIDO OR OPRA OR chemoradiation OR TME)) AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "(\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND ((\"rectal\"[Title/Abstract] OR \"rectum\"[Title/Abstract]) AND (\"trinitrotoluene\"[Supplementary Concept] OR \"trinitrotoluene\"[All Fields] OR \"tnt\"[All Fields] OR \"trinitrotoluene\"[MeSH Terms] OR \"total neoadjuvant\"[All Fields] OR 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chemotherapy)) AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "(\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND ((\"metastatically\"[All Fields] OR \"metastatics\"[All Fields] OR \"metastatization\"[All Fields] OR \"metastatize\"[All Fields] OR \"metastatized\"[All Fields] OR \"metastatizing\"[All Fields] OR \"secondary\"[MeSH Subheading] OR \"secondary\"[All Fields] OR \"metastatic\"[All Fields]) AND (\"FOLFOXIRI\"[All Fields] OR \"FOLFOX\"[All Fields] OR \"FOLFIRI\"[All Fields] OR (\"bevacizumab\"[Supplementary Concept] OR \"bevacizumab\"[All Fields] OR \"bevacizumab\"[MeSH Terms] OR \"bevacizumab s\"[All Fields]) OR (\"cetuximab\"[Supplementary Concept] OR \"cetuximab\"[All Fields] OR \"cetuximab\"[MeSH Terms] OR \"cetuximab s\"[All Fields]) OR 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Publication] : \"3000\"[Date - Publication])", "translation": "(\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"obstruct\"[All Fields] OR \"obstructed\"[All Fields] OR \"obstructing\"[All Fields] OR \"obstruction\"[All Fields] OR \"obstructions\"[All Fields] OR \"obstructive\"[All Fields] OR \"obstructs\"[All Fields] OR (\"perforant\"[All Fields] OR \"perforants\"[All Fields] OR \"perforate\"[All Fields] OR \"perforated\"[All Fields] OR \"perforates\"[All Fields] OR \"perforating\"[All Fields] OR \"perforation\"[All Fields] OR \"perforations\"[All Fields] OR \"perforative\"[All Fields] OR \"perforator\"[All Fields] OR \"perforator s\"[All Fields] OR \"perforators\"[All Fields]) OR (\"toxic\"[All Fields] OR \"toxical\"[All Fields] OR \"toxically\"[All Fields] OR \"toxicant\"[All Fields] 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cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"Practice Guideline\"[Publication Type] OR \"Guideline\"[Publication Type] OR \"Guideline\"[Title] OR \"clinical practice guideline\"[Title/Abstract] OR \"consensus statement\"[Title/Abstract]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 21, "ids": [ "42928004", "42906536", "42906535", "42831105", "42814894", "42814066", "42814045", "42771175", "42731257", "42711590", "42684532", "42683623", "42656090", "42604010", "42599724", "42517844", "42389808", "42364818", "41895479", "41770836", "41385753" ], "http": 200 }, { "topic": "rct", "cochrane": false, "query": "(\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND (\"Randomized Controlled Trial\"[pt] OR randomized[ti] OR randomised[ti]) AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "(\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"Randomized Controlled Trial\"[Publication Type] OR \"randomized\"[Title] OR \"randomised\"[Title]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 104, "ids": [ "42927853", "42927765", "42926107", "42925880", "42925093", "42909655", "42905707", "42905213", "42895896", "42892687", "42891491", "42884177", "42879156", "42875765", "42873277", "42871149", "42861260", "42859101", "42850173", "42841450", "42840411", "42838765", "42832110", "42830449", "42829779", "42816498", "42795032", "42791407", "42790919", "42785338", "42782000", "42778806", "42778242", "42777749", "42767745", "42765562", 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"(\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"Practice Guideline\"[Publication Type] OR \"Guideline\"[Publication Type]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 7, "ids": [ "42928004", "42814066", "42814045", "42683623", "42517844", "42389808", "42364818" ], "http": 200 }, { "topic": "high-impact", "cochrane": false, "query": "(\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND (\"N Engl J Med\"[jour] OR \"Lancet\"[jour] OR \"Lancet Oncol\"[jour] OR \"JAMA\"[jour] OR \"J Clin Oncol\"[jour] OR \"Ann Oncol\"[jour] OR \"Nat Med\"[jour] OR \"Gut\"[jour] OR \"Gastroenterology\"[jour] OR \"CA Cancer J Clin\"[jour] OR \"Lancet Gastroenterol Hepatol\"[jour]) AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "(\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"N Engl J Med\"[Journal] OR \"Lancet\"[Journal] OR \"Lancet Oncol\"[Journal] OR \"JAMA\"[Journal] OR \"J Clin Oncol\"[Journal] OR \"Ann Oncol\"[Journal] OR \"Nat Med\"[Journal] OR \"Gut\"[Journal] OR \"Gastroenterology\"[Journal] OR \"CA Cancer J Clin\"[Journal] OR \"Lancet Gastroenterol Hepatol\"[Journal]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 77, "ids": [ "42927858", "42927853", "42927765", "42926107", "42926106", "42925881", "42925880", "42919963", "42918895", "42914035", "42906564", "42906563", "42901758", "42863976", "42849474", "42849473", "42849472", "42849471", "42843898", "42843562", 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Publication\"[pt] OR \"Expression of Concern\"[pt]) AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "(\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"Retracted Publication\"[Publication Type] OR \"Expression of Concern\"[Publication Type]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 3, "ids": [ "42865666", "42844080", "42825377" ], "http": 200 }, { "topic": "entrez-since-2026-10-19", "cochrane": false, "query": "(\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND (\"2026/10/19\"[Date - Entrez] : \"3000\"[Date - Entrez])", "translation": "(\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND 2026/10/19:3000/12/31[Date - Entry]", "count": 279, "ids": [ "42928004", "42927974", "42927972", "42927969", "42927968", "42927947", "42927866", "42927858", "42927853", "42927765", "42927683", "42927618", "42927515", "42927376", "42927245", "42927153", "42927010", "42926972", "42926795", "42926737", "42926687", "42926548", "42926319", "42926227", "42926107", "42926106", "42926018", "42925957", "42925881", "42925880", "42925845", "42925819", "42925817", "42925765", "42925717", "42925093", "42925090", "42924986", "42924896", "42924863", "42924590", "42924496", "42924242", "42923923", "42923657", "42923574", "42923477", "42923466", "42923451", "42923192", "42923188", "42923187", "42923123", "42922856", "42922758", "42922651", "42922440", "42922222", "42922155", "42921908", "42921883", "42921854", 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Publication])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 1, "ids": [ "42770376" ], "http": 200 }, { "topic": "cochrane-burden-young-onset", "cochrane": true, "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND (epidemiolog* OR incidence OR mortality OR burden OR GLOBOCAN OR GBD OR disparit* OR \"early-onset\" OR \"young-onset\" OR \"early onset\" OR \"birth cohort\") AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"epidemiolog*\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading]) OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR \"GLOBOCAN\"[All Fields] OR \"GBD\"[All Fields] OR \"disparit*\"[All Fields] OR \"early-onset\"[All Fields] OR \"young-onset\"[All Fields] OR \"early-onset\"[All Fields] OR \"birth cohort\"[All Fields]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 1, "ids": [ "42770376" ], "http": 200 }, { "topic": "cochrane-carcinogenesis-serrated", "cochrane": true, "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND (adenoma OR serrated OR polyp* OR \"adenoma-carcinoma\" OR precursor OR field-effect OR \"field effect\") AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"adenoma\"[MeSH Terms] OR \"adenoma\"[All Fields] OR \"adenomas\"[All Fields] OR \"adenoma s\"[All Fields] OR (\"serrate\"[All Fields] OR \"serrated\"[All Fields] OR \"serration\"[All Fields] OR \"serrations\"[All Fields]) OR \"polyp*\"[All Fields] OR \"adenoma-carcinoma\"[All Fields] OR (\"precursor\"[All Fields] OR \"precursor s\"[All Fields] OR \"precursors\"[All Fields]) OR \"field-effect\"[All Fields] OR \"field-effect\"[All Fields]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 0, "ids": [], "http": 200 }, { "topic": "cochrane-molecular-subtypes", "cochrane": true, "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND (CMS OR \"consensus molecular\" OR microenvironment OR MSI OR microsatellite OR CIN OR \"chromosomal instability\") AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"comput manag sci\"[Journal] OR \"comp migr stud\"[Journal] OR \"commun math stat\"[Journal] OR \"clin mass spectrom\"[Journal] OR \"cms\"[All Fields] OR \"consensus molecular\"[All Fields] OR (\"microenvironment\"[All Fields] OR \"microenvironment s\"[All Fields] OR \"microenvironments\"[All Fields]) OR \"MSI\"[All Fields] OR (\"microsatellite repeats\"[MeSH Terms] OR (\"microsatellite\"[All Fields] AND \"repeats\"[All Fields]) OR \"microsatellite repeats\"[All Fields] OR \"microsatellite\"[All Fields] OR \"microsatellites\"[All Fields]) OR (\"comput nurs\"[Journal] OR \"comput intell neurosci\"[Journal] OR \"comput inform nurs\"[Journal] OR \"cin\"[All Fields]) OR \"chromosomal instability\"[All Fields]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 0, "ids": [], "http": 200 }, { "topic": "cochrane-hereditary-genetics", "cochrane": true, "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND (Lynch OR FAP OR polyposis OR germline OR hereditary OR \"mismatch repair\" OR MLH1 OR MSH2 OR APC[tiab]) AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"lynch\"[All Fields] OR \"lynch s\"[All Fields] OR \"FAP\"[All Fields] OR \"polyposis\"[All Fields] OR (\"germline\"[All Fields] OR \"germlines\"[All Fields]) OR \"hereditary\"[All Fields] OR \"mismatch repair\"[All Fields] OR (\"mlh1 protein human\"[Supplementary Concept] OR \"mlh1 protein human\"[All Fields] OR \"mlh1\"[All Fields]) OR \"MSH2\"[All Fields] OR \"APC\"[Title/Abstract]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 0, "ids": [], "http": 200 }, { "topic": "cochrane-screening", "cochrane": true, "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND (screening OR FIT OR \"fecal immunochemical\" OR colonoscopy OR \"stool DNA\" OR \"blood-based\" OR \"multi-cancer\" OR sigmoidoscopy) AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"diagnosis\"[MeSH Subheading] OR \"diagnosis\"[All Fields] OR \"screening\"[All Fields] OR \"mass screening\"[MeSH Terms] OR (\"mass\"[All Fields] AND \"screening\"[All Fields]) OR \"mass screening\"[All Fields] OR \"early detection of cancer\"[MeSH Terms] OR (\"early\"[All Fields] AND \"detection\"[All Fields] AND \"cancer\"[All Fields]) OR \"early detection of cancer\"[All Fields] OR \"screen\"[All Fields] OR \"screenings\"[All Fields] OR \"screened\"[All Fields] OR \"screens\"[All Fields] OR (\"seizures\"[MeSH Terms] OR \"seizures\"[All Fields] OR \"fit\"[All Fields]) OR \"fecal immunochemical\"[All Fields] OR (\"colonoscopy\"[MeSH Terms] OR \"colonoscopy\"[All Fields] OR \"colonoscopies\"[All Fields]) OR \"stool DNA\"[All Fields] OR \"blood-based\"[All Fields] OR \"multi-cancer\"[All Fields] OR (\"sigmoidoscopy\"[MeSH Terms] OR \"sigmoidoscopy\"[All Fields] OR \"sigmoidoscopies\"[All Fields])) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 0, "ids": [], "http": 200 }, { "topic": "cochrane-pathology-staging", "cochrane": true, "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND (patholog* OR staging OR TNM OR budding OR MMR OR immunohistochemistry OR \"circumferential resection\") AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND (\"patholog*\"[All Fields] OR (\"stage\"[All Fields] OR \"staged\"[All Fields] OR \"stages\"[All Fields] OR \"staging\"[All Fields] OR \"stagings\"[All Fields]) OR \"TNM\"[All Fields] OR (\"budded\"[All Fields] OR \"budding\"[All Fields] OR \"buddings\"[All Fields]) OR (\"mil med res\"[Journal] OR \"mmr\"[All Fields]) OR (\"immunohistochemistries\"[All Fields] OR \"immunohistochemistry\"[MeSH Terms] OR \"immunohistochemistry\"[All Fields]) OR \"circumferential resection\"[All Fields]) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 0, "ids": [], "http": 200 }, { "topic": "cochrane-localized-colon", "cochrane": true, "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND ((colon[tiab] OR colonic[tiab]) AND (adjuvant OR \"stage II\" OR \"stage III\" OR colectomy OR oxaliplatin OR IDEA OR MOSAIC)) AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND ((\"colon\"[Title/Abstract] OR \"colonic\"[Title/Abstract]) AND (\"adjuvancy\"[All Fields] OR \"adjuvanted\"[All Fields] OR \"adjuvanting\"[All Fields] OR \"adjuvants\"[All Fields] OR \"adjuvants pharmaceutic\"[Pharmacological Action] OR \"adjuvants immunologic\"[Pharmacological Action] OR \"adjuvants pharmaceutic\"[Supplementary Concept] OR \"adjuvants pharmaceutic\"[All Fields] OR \"adjuvant\"[All Fields] OR \"adjuvants immunologic\"[Supplementary Concept] OR \"adjuvants immunologic\"[All Fields] OR \"adjuvants, pharmaceutic\"[MeSH Terms] OR (\"adjuvants\"[All Fields] AND \"pharmaceutic\"[All Fields]) OR \"pharmaceutic adjuvants\"[All Fields] OR \"adjuvants, immunologic\"[MeSH Terms] OR (\"adjuvants\"[All Fields] AND \"immunologic\"[All Fields]) OR \"immunologic adjuvants\"[All Fields] OR \"adjuvated\"[All Fields] OR \"adjuvation\"[All Fields] OR \"adjuvent\"[All Fields] OR \"stage II\"[All Fields] OR \"stage III\"[All Fields] OR (\"colectomy\"[MeSH Terms] OR \"colectomy\"[All Fields] OR \"colectomies\"[All Fields]) OR (\"oxaliplatin\"[Supplementary Concept] OR \"oxaliplatin\"[All Fields] OR \"oxaliplatin\"[MeSH Terms] OR \"oxaliplatine\"[All Fields] OR \"oxaliplatin s\"[All Fields]) OR (\"idea j law technol\"[Journal] OR \"idea\"[All Fields]) OR (\"mosaic\"[All Fields] OR \"mosaicism\"[MeSH Terms] OR \"mosaicism\"[All Fields] OR \"mosaicisms\"[All Fields] OR \"mosaics\"[All Fields]))) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 0, "ids": [], "http": 200 }, { "topic": "cochrane-localized-rectal", "cochrane": true, "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND ((rectal[tiab] OR rectum[tiab]) AND (TNT OR \"total neoadjuvant\" OR \"watch and wait\" OR \"watch-and-wait\" OR \"organ preservation\" OR RAPIDO OR OPRA OR chemoradiation OR TME)) AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR \"colorectal adenocarcinoma\"[Title/Abstract] OR \"colon cancer\"[Title/Abstract] OR \"rectal cancer\"[Title/Abstract] OR \"colorectal carcinoma\"[Title/Abstract]) AND ((\"rectal\"[Title/Abstract] OR \"rectum\"[Title/Abstract]) AND (\"trinitrotoluene\"[Supplementary Concept] OR \"trinitrotoluene\"[All Fields] OR \"tnt\"[All Fields] OR \"trinitrotoluene\"[MeSH Terms] OR \"total neoadjuvant\"[All Fields] OR \"watch-and-wait\"[All Fields] OR \"watch-and-wait\"[All Fields] OR \"organ preservation\"[All Fields] OR \"RAPIDO\"[All Fields] OR \"OPRA\"[All Fields] OR (\"chemoradiotherapy\"[MeSH Terms] OR \"chemoradiotherapy\"[All Fields] OR \"chemoradiation\"[All Fields]) OR (\"tumor microenviron\"[Journal] OR \"tme\"[All Fields]))) AND 2026/08/28:3000/12/31[Date - Publication]", "count": 0, "ids": [], "http": 200 }, { "topic": "cochrane-metastatic-systemic", "cochrane": true, "query": "\"Cochrane Database Syst Rev\"[jour] AND (\"Colorectal Neoplasms\"[Mesh] OR \"colorectal cancer\"[tiab] OR \"colorectal adenocarcinoma\"[tiab] OR \"colon cancer\"[tiab] OR \"rectal cancer\"[tiab] OR \"colorectal carcinoma\"[tiab]) AND (metastatic AND (FOLFOXIRI OR FOLFOX OR FOLFIRI OR bevacizumab OR cetuximab OR panitumumab OR maintenance OR TRIBE OR chemotherapy)) AND (\"2026/08/28\"[Date - Publication] : \"3000\"[Date - Publication])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"Colorectal Neoplasms\"[MeSH Terms] OR \"colorectal cancer\"[Title/Abstract] OR 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