{ "date": "2026-10-20", "window": { "from": "2026-10-13", "to": "2026-10-20", "field": "PubMed Date - Publication; Europe PMC FIRST_PDATE" }, "contact_email_used": false, "unpaywall": "skipped; LIFEBANK_CONTACT_EMAIL unset", "sources_queried": [ "PubMed E-utilities esearch/esummary/efetch", "Europe PMC REST search", "ClinicalTrials.gov API v2", "Crossref works (title and DOI)", "OpenAlex works filter", "DOAJ article search (not date-restricted; not used for citation)", "ISRCTN API query format/default", "EU CTIS public API (HTTP 403)", "ChiCTR English search (HTTP 405 / undecodable)", "CTRI landing page (declaration form)", "WHO ICTRP portal (JS-driven; no programmatic results)", "NICE, EMA, FDA, AWMF, WHO fact sheet, Alzheimer's Association, ADI, Alzheimer's Society (direct fetch)" ], "sources_unreachable": [ { "source": "cochranelibrary.com / CENTRAL", "status": "HTTP 403" }, { "source": "search.scielo.org / LILACS", "status": "HTTP 403" }, { "source": "EU CTIS public API", "status": "HTTP 403" }, { "source": "ChiCTR programmatic search", "status": "HTTP 405 or undecodable" } ], "pubmed": { "broad_ad": { "query": "(Alzheimer*[tiab] OR \"Alzheimer Disease\"[mh]) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"Alzheimer Disease\"[MeSH Terms]) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 242, "ids": [ "42896796", "42896468", "42896306", "42895818", "42895756", "42895713", "42895489", "42895176", "42895155", "42895154", "42895147", "42894634", "42894627", "42894599", "42894479", "42894248", "42894207", "42894195", "42893889", "42893780", "42893747", "42892741", "42892493", "42892457", "42892388", "42892274", "42891822", "42891802", "42891801", "42891615", "42891040", "42890838", "42890602", "42890483", "42890315", "42890170", "42889888", "42888935", "42888370", "42888346", "42888163", "42887875", "42887710", "42887705", "42887669", "42887664", "42887430", "42887235", "42887066", "42887030", "42886879", "42886878", "42886876", "42886871", "42886802", "42886392", "42886279", "42885968", "42885915", "42885693", "42885691", "42885690", "42885688", "42885687", "42885682", "42885680", "42885677", "42885674", "42885673", "42885665", "42885191", "42881225", "42880986", "42880601", "42880559", "42880558", "42880555", "42880289", "42880287", "42880056", "42880054", "42880003", "42879978", "42879974", "42879727", "42879726", "42879228", "42879070", "42879058", "42878972", "42878916", "42878720", "42878653", "42878651", "42878647", "42878617", "42878502", "42877708", "42877606", "42877556", "42876885", "42876854", "42876597", "42876052", "42875818", "42875809", "42875694", "42875680", "42875646", "42875639", "42875638", "42875627", "42875562", "42875556", "42874953", "42874949", "42874875", "42874747", "42874425", "42874293", "42874250", "42874179", "42873892", "42873864", "42873676", "42873658", "42873606", "42873451", "42873408", "42873357", "42873344", "42873210", "42873092", "42872646", "42872643", "42872589", "42872112", "42870413", "42870189", "42869662", "42869342", "42869338", "42869308", "42869255", "42869229", "42869138", "42869105", "42869027", "42868934", "42868172", "42868046", "42868044", "42868043", "42868033", "42868017", "42867945", "42867929", "42867924", "42867762", "42867690", "42867612", "42867611", "42867534", "42867198", "42865106", "42864705", "42864178", "42863052", "42852552", "42833256", "42832655", "42831322", "42830961", "42825683", "42788140", "42784895", "42780659", "42778072", "42765029", "42761867", "42759392", "42759390", "42758499", "42757589", "42748981", "42735059", "42732855", "42731186", "42722309", "42722213", "42721523", "42716318", "42716316", "42710552", "42710551", "42700779", "42691626", "42690079", "42689388", "42689376", "42678362", "42674339", "42667935", "42647766", "42637537", "42637536", "42632510", "42632354", "42624449", "42618108", "42618102", "42617977", "42617975", "42612783", "42607896", "42607731", "42603633", "42595023", "42575313", "42562307", "42561665", "42556278", "42543113", "42535671", "42532327", "42526376", "42492602", "42492469", "42490402", "42471077", "42470846", "42437499", "42425257", "42320781", "42320199", "42297098", "42288030", "42217399", "42171655", "42166920", "42127553", "41876055" ] }, "diagnosis_staging": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (diagnos* OR stag* OR criteria OR disclosure) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"diagnos*\"[All Fields] OR \"stag*\"[All Fields] OR (\"criteria s\"[All Fields] OR \"criterias\"[All Fields] OR \"standards\"[MeSH Subheading] OR \"standards\"[All Fields] OR \"criteria\"[All Fields]) OR (\"disclosure\"[MeSH Terms] OR \"disclosure\"[All Fields] OR \"disclosures\"[All Fields] OR \"disclosure s\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 124, "ids": [ "42897099", "42896595", "42896468", "42895713", "42895276", "42895154", "42894627", "42893889", "42892741", "42892457", "42892388", "42891981", "42891802", "42891615", "42891040", "42890838", "42890602", "42888935", "42888867", "42888381", "42887710", "42887669", "42887093", "42887030", "42886896", "42886878", "42886392", "42886279", "42885968", "42885693", "42885691", "42885690", "42885682", "42885677", "42885674", "42885481", "42881403", "42881367", "42880791", "42880601", "42880559", "42880555", "42880054", "42880003", "42879726", "42879274", "42879228", "42879070", "42878720", "42878653", "42878651", "42878617", "42878527", "42878155", "42877708", "42877606", "42877556", "42876885", "42876348", "42875694", "42875646", "42875639", "42875627", "42874953", "42874425", "42874293", "42874246", "42874179", "42874008", "42873676", "42873606", "42873489", "42873408", "42873209", "42873092", "42870189", "42869338", "42868934", "42868090", "42868046", "42868044", "42868033", "42867945", "42867924", "42867762", "42867534", "42867198", "42864763", "42830961", "42825683", "42785596", "42784895", "42763025", "42761867", "42757589", "42748981", "42735059", "42722309", "42721523", "42721413", "42710551", "42709848", "42689376", "42678362", "42674339", "42648504", "42647766", "42624449", "42618108", "42618102", "42617977", "42595023", "42572281", "42532327", "42471077", "42470846", "42437499", "42297098", "42288030", "42217636", "42217399", "42215028", "42171655", "41874954" ] }, "epidemiology_burden": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (prevalence OR incidence OR mortality OR burden OR cost) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading]) OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR (\"economics\"[MeSH Subheading] OR \"economics\"[All Fields] OR \"cost\"[All Fields] OR \"costs and cost analysis\"[MeSH Terms] OR (\"costs\"[All Fields] AND \"cost\"[All Fields] AND \"analysis\"[All Fields]) OR \"costs and cost analysis\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 100, "ids": [ "42897099", "42896595", "42896464", "42896356", "42896306", "42895818", "42895713", "42895276", "42895176", "42894627", "42894207", "42892274", "42891943", "42891802", "42891466", "42890838", "42890315", "42888596", "42888381", "42888145", "42887694", "42887430", "42887093", "42886896", "42886878", "42886877", "42886876", "42886871", "42886585", "42886077", "42885809", "42885693", "42885691", "42885682", "42885680", "42885674", "42885481", "42885233", "42885214", "42881403", "42881367", "42880986", "42880601", "42880558", "42879726", "42879274", "42879257", "42878675", "42878417", "42878155", "42877918", "42877708", "42877556", "42876348", "42876052", "42875826", "42875818", "42875639", "42875556", "42874883", "42874747", "42874425", "42874293", "42874249", "42874179", "42874008", "42873521", "42873451", "42872383", "42872112", "42869753", "42869308", "42868934", "42868172", "42868046", "42867945", "42867611", "42867534", "42864705", "42831322", "42825683", "42761867", "42757589", "42722309", "42722213", "42716316", "42710551", "42709848", "42648504", "42647766", "42612783", "42607896", "42575313", "42572281", "42556278", "42532327", "42471077", "42470846", "42437499", "42171655" ] }, "genetics_risk": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (APOE OR genetic* OR genome OR risk) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"apolipoproteins e\"[Supplementary Concept] OR \"apolipoproteins e\"[All Fields] OR \"apoe\"[All Fields] OR \"apoe protein human\"[Supplementary Concept] OR \"apoe protein human\"[All Fields] OR \"apolipoproteins e\"[MeSH Terms] OR \"genetic*\"[All Fields] OR (\"genome\"[MeSH Terms] OR \"genome\"[All Fields] OR \"genomes\"[All Fields] OR \"genome s\"[All Fields] OR \"genomically\"[All Fields] OR \"genomics\"[MeSH Terms] OR \"genomics\"[All Fields] OR \"genomic\"[All Fields]) OR (\"risk\"[MeSH Terms] OR \"risk\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 136, "ids": [ "42896464", "42896356", "42896306", "42896219", "42895276", "42894627", "42894325", "42892741", "42892388", "42891943", "42891822", "42891801", "42890838", "42890602", "42890315", "42888868", "42888381", "42888346", "42887093", "42887030", "42886997", "42886896", "42886879", "42886878", "42886876", "42886871", "42886392", "42886077", "42885809", "42885688", "42885682", "42885680", "42885677", "42885481", "42885312", "42885233", "42885110", "42881403", "42881367", "42881225", "42881068", "42880601", "42880555", "42880287", "42880054", "42880003", "42879727", "42879058", "42878916", "42878502", "42878155", "42877918", "42877708", "42877606", "42876597", "42876348", "42876073", "42876052", "42875826", "42875818", "42875639", "42875638", "42874591", "42874425", "42874293", "42874179", "42874008", "42873892", "42873864", "42873658", "42873606", "42873521", "42873451", "42873408", "42873210", "42872646", "42872589", "42872383", "42872112", "42870413", "42869753", "42869662", "42869650", "42869255", "42869229", "42869105", "42869027", "42868172", "42867762", "42867690", "42867612", "42867611", "42864705", "42863052", "42833256", "42830961", "42763025", "42761867", "42759390", "42757589", "42748981", "42735059", "42732855", "42731186", "42722309", "42722213", "42721413", "42716318", "42710551", "42700779", "42696687", "42696686", "42696685", "42696684", "42696683", "42689388", "42689376", "42647766", "42632510", "42618108", "42617977", "42607896", "42607731", "42603633", "42575313", "42556278", "42535671", "42490402", "42471077", "42437499", "42425257", "42297098", "42217636", "42171655", "42127553", "41876055" ] }, "amyloid_tau": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (amyloid OR tau OR neuropathology) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"amyloid\"[Supplementary Concept] OR \"amyloid\"[All Fields] OR \"amyloids\"[All Fields] OR \"amyloid\"[MeSH Terms] OR \"amyloidal\"[All Fields] OR \"amyloidic\"[All Fields] OR \"app protein human\"[Supplementary Concept] OR \"app protein human\"[All Fields] OR (\"transl androl urol\"[Journal] OR \"tau\"[All Fields]) OR (\"neuropathology\"[MeSH Terms] OR \"neuropathology\"[All Fields] OR \"neuropathologies\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 122, "ids": [ "42896306", "42894479", "42894248", "42893780", "42892457", "42892388", "42892274", "42891822", "42890838", "42890602", "42890483", "42890315", "42888346", "42887875", "42887710", "42887705", "42887235", "42887030", "42886878", "42886876", "42886279", "42885968", "42885691", "42885690", "42885687", "42885677", "42885673", "42885665", "42880559", "42880558", "42880287", "42880054", "42879726", "42879070", "42878972", "42878916", "42878720", "42878653", "42878502", "42877918", "42877708", "42876885", "42876854", "42876597", "42875680", "42875646", "42875639", "42875638", "42875627", "42875556", "42874747", "42874425", "42874179", "42873892", "42873864", "42873676", "42873606", "42873408", "42873357", "42873344", "42873092", "42872646", "42872643", "42872112", "42870189", "42869342", "42869308", "42869138", "42868172", "42868046", "42868033", "42868017", "42867924", "42867762", "42867690", "42867612", "42867534", "42865106", "42863052", "42852552", "42833256", "42830961", "42780659", "42765029", "42761867", "42759390", "42732855", "42731186", "42722309", "42721523", "42716318", "42716316", "42710552", "42710551", "42691626", "42690079", "42689388", "42689376", "42678362", "42667935", "42637536", "42632510", "42618102", "42617975", "42607896", "42607731", "42562307", "42561665", "42556278", "42532327", "42526376", "42492469", "42471077", "42437499", "42425257", "42320199", "42297098", "42288030", "42171655", "42166920", "42127553", "41876055" ] }, "glia_vascular_metabolic": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (microglia OR neuroinflamm* OR vascular OR metabolic) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"microglia\"[MeSH Terms] OR \"microglia\"[All Fields] OR \"microglias\"[All Fields] OR \"microglia s\"[All Fields] OR \"neuroinflamm*\"[All Fields] OR (\"blood vessels\"[MeSH Terms] OR (\"blood\"[All Fields] AND \"vessels\"[All Fields]) OR \"blood vessels\"[All Fields] OR \"vascular\"[All Fields] OR \"vascularisation\"[All Fields] OR \"neovascularization, pathologic\"[MeSH Terms] OR (\"neovascularization\"[All Fields] AND \"pathologic\"[All Fields]) OR \"pathologic neovascularization\"[All Fields] OR \"vascularization\"[All Fields] OR \"vascularisations\"[All Fields] OR \"vascularise\"[All Fields] OR \"vascularised\"[All Fields] OR \"vascularities\"[All Fields] OR \"vascularitis\"[All Fields] OR \"vascularity\"[All Fields] OR \"vascularizations\"[All Fields] OR \"vascularize\"[All Fields] OR \"vascularized\"[All Fields] OR \"vascularizes\"[All Fields] OR \"vascularizing\"[All Fields] OR \"vasculars\"[All Fields]) OR (\"metabolic\"[All Fields] OR \"metabolical\"[All Fields] OR \"metabolically\"[All Fields] OR \"metabolics\"[All Fields] OR \"metabolism\"[MeSH Terms] OR \"metabolism\"[All Fields] OR \"metabolisms\"[All Fields] OR \"metabolism\"[MeSH Subheading] OR \"metabolities\"[All Fields] OR \"metabolization\"[All Fields] OR \"metabolize\"[All Fields] OR \"metabolized\"[All Fields] OR \"metabolizer\"[All Fields] OR \"metabolizers\"[All Fields] OR \"metabolizes\"[All Fields] OR \"metabolizing\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 145, "ids": [ "42896796", "42896468", "42895276", "42895155", "42895147", "42894634", "42894627", "42894599", "42894325", "42893889", "42893747", "42892457", "42891822", "42891801", "42891615", "42890838", "42890483", "42890170", "42889888", "42887875", "42887710", "42887705", "42887669", "42887430", "42887235", "42886878", "42886876", "42886802", "42886392", "42886279", "42885915", "42885682", "42885680", "42885677", "42885481", "42881225", "42880601", "42880287", "42880056", "42879274", "42879070", "42879058", "42878972", "42878916", "42878720", "42878651", "42878502", "42876885", "42876854", "42876597", "42876052", "42875809", "42875680", "42875646", "42875639", "42875638", "42875627", "42875556", "42874993", "42874953", "42874747", "42874697", "42874293", "42873892", "42873864", "42873676", "42873408", "42873357", "42873344", "42873210", "42872643", "42872589", "42872112", "42870189", "42869338", "42869138", "42869105", "42869027", "42868046", "42868044", "42868033", "42868017", "42867929", "42867924", "42867762", "42867612", "42867611", "42867534", "42863052", "42833256", "42831322", "42780659", "42778072", "42765029", "42763025", "42759392", "42759390", "42757589", "42748981", "42735059", "42732855", "42731186", "42727710", "42722309", "42722213", "42721523", "42721413", "42716318", "42716316", "42710551", "42700779", "42691626", "42690079", "42689388", "42689376", "42678362", "42667935", "42632510", "42624449", "42618108", "42618102", "42617977", "42617975", "42612783", "42607896", "42607731", "42603633", "42575313", "42562307", "42561665", "42556278", "42532327", "42492469", "42471077", "42437499", "42425257", "42320781", "42320199", "42297098", "42288030", "42217399", "42166920", "42127553", "42035861", "41876055" ] }, "fluid_biomarkers": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (plasma OR blood OR cerebrospinal OR biomarker*) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"plasma\"[MeSH Terms] OR \"plasma\"[All Fields] OR \"plasmas\"[All Fields] OR \"plasma s\"[All Fields] OR (\"blood\"[MeSH Subheading] OR \"blood\"[All Fields] OR \"blood\"[MeSH Terms] OR \"bloods\"[All Fields] OR \"haematology\"[All Fields] OR \"hematology\"[MeSH Terms] OR \"hematology\"[All Fields] OR \"haematoma\"[All Fields] OR \"hematoma\"[MeSH Terms] OR \"hematoma\"[All Fields] OR \"haemorrhage\"[All Fields] OR \"hemorrhage\"[MeSH Terms] OR \"hemorrhage\"[All Fields] OR \"haemorrhages\"[All Fields] OR \"hemorrhages\"[All Fields] OR \"haemorrhagic\"[All Fields] OR \"haemorrhaging\"[All Fields] OR \"hematologies\"[All Fields] OR \"haematomas\"[All Fields] OR \"hematomas\"[All Fields] OR \"hematoma s\"[All Fields] OR \"hematomae\"[All Fields] OR \"hemorrhaged\"[All Fields] OR \"hemorrhagic\"[All Fields] OR \"hemorrhagical\"[All Fields] OR \"hemorrhaging\"[All Fields]) OR \"cerebrospinal\"[All Fields] OR \"biomarker*\"[All Fields]) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 106, "ids": [ "42895756", "42895154", "42894634", "42894599", "42892741", "42892493", "42892457", "42892388", "42891822", "42891615", "42890838", "42890602", "42888935", "42888867", "42888381", "42888163", "42887710", "42887669", "42887235", "42887030", "42886878", "42886876", "42886392", "42886279", "42885968", "42885809", "42885691", "42885690", "42885682", "42885677", "42885673", "42885665", "42885481", "42885214", "42885191", "42885110", "42880559", "42880558", "42880555", "42880054", "42879727", "42879274", "42878972", "42878916", "42878720", "42877918", "42877606", "42875694", "42875680", "42875639", "42875627", "42874425", "42874179", "42873892", "42873676", "42873606", "42873451", "42873408", "42873357", "42873092", "42872646", "42872643", "42872588", "42872112", "42870189", "42869308", "42868046", "42868017", "42867924", "42867762", "42867612", "42867611", "42865106", "42864705", "42864178", "42852552", "42778072", "42761867", "42758499", "42757589", "42748981", "42732855", "42722309", "42721413", "42691626", "42678362", "42647766", "42637536", "42624449", "42618108", "42618102", "42607731", "42595023", "42575313", "42572281", "42562307", "42532327", "42526376", "42471077", "42320781", "42297098", "42217399", "42171655", "42166920", "42127553", "41876055" ] }, "imaging": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (PET OR MRI OR imaging OR atrophy) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"PET\"[All Fields] OR (\"magnetic resonance imaging\"[MeSH Terms] OR (\"magnetic\"[All Fields] AND \"resonance\"[All Fields] AND \"imaging\"[All Fields]) OR \"magnetic resonance imaging\"[All Fields] OR \"mri\"[All Fields]) OR (\"image s\"[All Fields] OR \"imaged\"[All Fields] OR \"imager\"[All Fields] OR \"imager s\"[All Fields] OR \"imagers\"[All Fields] OR \"images\"[All Fields] OR \"imaging\"[All Fields] OR \"imaging s\"[All Fields] OR \"imagings\"[All Fields] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[Supplementary Concept] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[All Fields] OR \"image\"[All Fields]) OR (\"atrophie\"[All Fields] OR \"atrophy\"[MeSH Terms] OR \"atrophy\"[All Fields] OR \"atrophied\"[All Fields] OR \"atrophies\"[All Fields] OR \"atrophying\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 67, "ids": [ "42896595", "42896468", "42896306", "42892457", "42892388", "42892274", "42891802", "42891801", "42890315", "42889888", "42888163", "42887710", "42887030", "42886896", "42886878", "42886585", "42886392", "42885691", "42885690", "42885665", "42885481", "42880559", "42880558", "42880289", "42880054", "42879978", "42879274", "42879228", "42878653", "42876073", "42875694", "42875680", "42875639", "42875627", "42875556", "42874425", "42874179", "42873676", "42873606", "42873092", "42872646", "42872588", "42869338", "42869229", "42869027", "42867924", "42867611", "42864178", "42852552", "42830961", "42785596", "42784895", "42761867", "42731186", "42722309", "42721523", "42721413", "42648504", "42647766", "42632510", "42595023", "42535671", "42532327", "42492469", "42470846", "42437499", "42171655" ] }, "anti_amyloid": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (lecanemab OR donanemab OR antibody OR ARIA) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"lecanemab\"[Supplementary Concept] OR \"lecanemab\"[All Fields] OR (\"donanemab\"[Supplementary Concept] OR \"donanemab\"[All Fields]) OR (\"antibodie\"[All Fields] OR \"antibodies\"[Supplementary Concept] OR \"antibodies\"[All Fields] OR \"antibodies\"[MeSH Terms] OR \"antibody s\"[All Fields] OR \"antibodys\"[All Fields] OR \"immunoglobulins\"[Supplementary Concept] OR \"immunoglobulins\"[All Fields] OR \"antibody\"[All Fields] OR \"immunoglobulins\"[MeSH Terms]) OR (\"nrg1 protein human\"[Supplementary Concept] OR \"nrg1 protein human\"[All Fields] OR \"aria\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 21, "ids": [ "42892274", "42890315", "42887030", "42886878", "42885677", "42885110", "42880054", "42879726", "42878653", "42875639", "42875627", "42874425", "42873892", "42872646", "42872588", "42765029", "42678362", "42543113", "42437499", "42217399", "42127553" ] }, "symptomatic_nps": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (cholinesterase OR memantine OR agitation OR psychosis OR sleep) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"cholinesterases\"[Supplementary Concept] OR \"cholinesterases\"[All Fields] OR \"cholinesterase\"[All Fields] OR \"cholinesterases\"[MeSH Terms] OR \"cholinesterasic\"[All Fields] OR (\"memantine\"[Supplementary Concept] OR \"memantine\"[All Fields] OR \"memantin\"[All Fields] OR \"memantine\"[MeSH Terms] OR \"memantine s\"[All Fields]) OR (\"agitate\"[All Fields] OR \"agitated\"[All Fields] OR \"agitates\"[All Fields] OR \"agitating\"[All Fields] OR \"agitation\"[All Fields] OR \"agitations\"[All Fields] OR \"agitator\"[All Fields] OR \"agitators\"[All Fields]) OR (\"psychotic disorders\"[MeSH Terms] OR (\"psychotic\"[All Fields] AND \"disorders\"[All Fields]) OR \"psychotic disorders\"[All Fields] OR \"psychosis\"[All Fields]) OR (\"sleep\"[MeSH Terms] OR \"sleep\"[All Fields] OR \"sleeping\"[All Fields] OR \"sleeps\"[All Fields] OR \"sleep s\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 22, "ids": [ "42893780", "42893747", "42888868", "42888370", "42886077", "42885680", "42885674", "42885233", "42877708", "42877556", "42875646", "42873521", "42864758", "42788140", "42759392", "42674339", "42535671", "42490402", "42470846", "42320199", "42288030", "42171655" ] }, "prevention": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (prevention OR lifestyle OR exercise OR diet OR hearing) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"prevent\"[All Fields] OR \"preventability\"[All Fields] OR \"preventable\"[All Fields] OR \"preventative\"[All Fields] OR \"preventatively\"[All Fields] OR \"preventatives\"[All Fields] OR \"prevented\"[All Fields] OR \"preventing\"[All Fields] OR \"prevention and control\"[MeSH Subheading] OR (\"prevention\"[All Fields] AND \"control\"[All Fields]) OR \"prevention and control\"[All Fields] OR \"prevention\"[All Fields] OR \"prevention s\"[All Fields] OR \"preventions\"[All Fields] OR \"preventive\"[All Fields] OR \"preventively\"[All Fields] OR \"preventives\"[All Fields] OR \"prevents\"[All Fields] OR (\"life style\"[MeSH Terms] OR (\"life\"[All Fields] AND \"style\"[All Fields]) OR \"life style\"[All Fields] OR \"lifestyle\"[All Fields] OR \"lifestyles\"[All Fields]) OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]) OR (\"diet\"[MeSH Terms] OR \"diet\"[All Fields]) OR (\"hearing\"[MeSH Terms] OR \"hearing\"[All Fields] OR \"hearings\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 63, "ids": [ "42896464", "42896306", "42895713", "42895489", "42894627", "42894325", "42894207", "42891943", "42890602", "42888868", "42888381", "42888346", "42888145", "42887875", "42887694", "42887030", "42886997", "42886879", "42886876", "42886279", "42885809", "42885682", "42885680", "42881403", "42881367", "42881225", "42881068", "42880601", "42880054", "42879058", "42878972", "42878675", "42878502", "42877708", "42877606", "42876348", "42876073", "42875826", "42874697", "42874008", "42873864", "42873658", "42873521", "42873451", "42869753", "42869338", "42869105", "42868044", "42868043", "42868033", "42867611", "42864705", "42825683", "42778072", "42757589", "42735059", "42722213", "42689376", "42632354", "42618102", "42612783", "42607896", "42217636" ] }, "care_patient": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (caregiv* OR care OR patient* OR stigma OR experience) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"caregiv*\"[All Fields] OR \"care\"[All Fields] OR \"patient*\"[All Fields] OR (\"social stigma\"[MeSH Terms] OR (\"social\"[All Fields] AND \"stigma\"[All Fields]) OR \"social stigma\"[All Fields] OR \"stigma\"[All Fields] OR \"stigmas\"[All Fields] OR \"stigma s\"[All Fields]) OR (\"experience\"[All Fields] OR \"experience s\"[All Fields] OR \"experiences\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 120, "ids": [ "42897099", "42896881", "42896356", "42896219", "42895818", "42895489", "42894207", "42894195", "42893253", "42892274", "42891981", "42891943", "42891822", "42891802", "42891615", "42890838", "42890602", "42890315", "42889540", "42888935", "42888868", "42888867", "42888381", "42888370", "42888346", "42888163", "42888145", "42887710", "42887669", "42887093", "42886997", "42886896", "42886585", "42886077", "42885968", "42885691", "42885690", "42885677", "42885674", "42885312", "42885233", "42885110", "42881403", "42880054", "42880003", "42879978", "42879974", "42879726", "42879498", "42879274", "42879257", "42879228", "42878675", "42878653", "42878651", "42878617", "42878527", "42878417", "42877918", "42877708", "42877606", "42877556", "42876885", "42876052", "42875818", "42875809", "42875734", "42875639", "42875627", "42874425", "42874293", "42874249", "42874246", "42874179", "42874008", "42873625", "42873521", "42873489", "42873408", "42873209", "42873092", "42872588", "42872383", "42872112", "42870413", "42869753", "42869650", "42869338", "42868934", "42868877", "42868090", "42867945", "42867762", "42867198", "42864763", "42864758", "42864705", "42864178", "42863052", "42785596", "42765029", "42727710", "42722309", "42722213", "42710551", "42709848", "42689376", "42674339", "42647766", "42637537", "42618108", "42603633", "42575313", "42572281", "42470846", "42437499", "42217636", "42215028", "42035861", "41876055" ] }, "guidelines_trials": { "query": "(Alzheimer*[tiab] OR dementia[tiab]) AND (guideline* OR consensus OR trial* OR treatment) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"dementia\"[Title/Abstract]) AND (\"guideline*\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR \"trial*\"[All Fields] OR (\"therapeutics\"[MeSH Terms] OR \"therapeutics\"[All Fields] OR \"treatments\"[All Fields] OR \"therapy\"[MeSH Subheading] OR \"therapy\"[All Fields] OR \"treatment\"[All Fields] OR \"treatment s\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 133, "ids": [ "42897099", "42895489", "42895155", "42895147", "42894634", "42894248", "42893253", "42892457", "42892274", "42891981", "42891801", "42890838", "42890602", "42890315", "42890170", "42889888", "42888868", "42888867", "42888381", "42888370", "42888346", "42887710", "42887705", "42887669", "42887093", "42887030", "42886802", "42886585", "42886392", "42886279", "42885915", "42885691", "42885680", "42885677", "42885674", "42885312", "42885214", "42885191", "42885110", "42881367", "42881225", "42880601", "42880559", "42880555", "42880289", "42880287", "42880054", "42879978", "42879726", "42879274", "42879058", "42878972", "42878417", "42877918", "42877708", "42877606", "42876885", "42876597", "42875809", "42875734", "42875646", "42875639", "42875638", "42875627", "42875556", "42874993", "42874747", "42874591", "42874425", "42874179", "42874008", "42873892", "42873864", "42873658", "42873625", "42873521", "42873489", "42873451", "42873357", "42873344", "42872646", "42872643", "42870413", "42869753", "42869650", "42869342", "42869105", "42869027", "42868090", "42868046", "42868033", "42867945", "42867929", "42867762", "42867612", "42867198", "42833256", "42831322", "42830961", "42778072", "42759390", "42757589", "42735059", "42732855", "42731186", "42721523", "42716318", "42710552", "42710551", "42709848", "42691626", "42689376", "42647766", "42637536", "42632510", "42632354", "42624449", "42617975", "42612783", "42607896", "42603633", "42572281", "42561665", "42556278", "42471077", "42437499", "42320781", "42320199", "42288030", "42217399", "42215028", "42166920", "42035861" ] }, "cochrane_diagnosis_staging": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (diagnos* OR stag* OR criteria OR disclosure) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"diagnos*\"[All Fields] OR \"stag*\"[All Fields] OR (\"criteria s\"[All Fields] OR \"criterias\"[All Fields] OR \"standards\"[MeSH Subheading] OR \"standards\"[All Fields] OR \"criteria\"[All Fields]) OR (\"disclosure\"[MeSH Terms] OR \"disclosure\"[All Fields] OR \"disclosures\"[All Fields] OR \"disclosure s\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 1, "ids": [ "42878653" ] }, "cochrane_epidemiology_burden": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (prevalence OR incidence OR mortality OR burden OR cost) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"prevalence\"[All Fields] OR \"prevalence\"[MeSH Terms] OR \"prevalance\"[All Fields] OR \"prevalences\"[All Fields] OR \"prevalence s\"[All Fields] OR \"prevalent\"[All Fields] OR \"prevalently\"[All Fields] OR \"prevalents\"[All Fields] OR (\"epidemiology\"[MeSH Subheading] OR \"epidemiology\"[All Fields] OR \"incidence\"[All Fields] OR \"incidence\"[MeSH Terms] OR \"incidences\"[All Fields] OR \"incident\"[All Fields] OR \"incidents\"[All Fields]) OR (\"mortality\"[MeSH Terms] OR \"mortality\"[All Fields] OR \"mortalities\"[All Fields] OR \"mortality\"[MeSH Subheading]) OR (\"burden\"[All Fields] OR \"burdened\"[All Fields] OR \"burdening\"[All Fields] OR \"burdens\"[All Fields]) OR (\"economics\"[MeSH Subheading] OR \"economics\"[All Fields] OR \"cost\"[All Fields] OR \"costs and cost analysis\"[MeSH Terms] OR (\"costs\"[All Fields] AND \"cost\"[All Fields] AND \"analysis\"[All Fields]) OR \"costs and cost analysis\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 0, "ids": [] }, "cochrane_genetics_risk": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (APOE OR genetic* OR genome OR risk) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"apolipoproteins e\"[Supplementary Concept] OR \"apolipoproteins e\"[All Fields] OR \"apoe\"[All Fields] OR \"apoe protein human\"[Supplementary Concept] OR \"apoe protein human\"[All Fields] OR \"apolipoproteins e\"[MeSH Terms] OR \"genetic*\"[All Fields] OR (\"genome\"[MeSH Terms] OR \"genome\"[All Fields] OR \"genomes\"[All Fields] OR \"genome s\"[All Fields] OR \"genomically\"[All Fields] OR \"genomics\"[MeSH Terms] OR \"genomics\"[All Fields] OR \"genomic\"[All Fields]) OR (\"risk\"[MeSH Terms] OR \"risk\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 0, "ids": [] }, "cochrane_amyloid_tau": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (amyloid OR tau OR neuropathology) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"amyloid\"[Supplementary Concept] OR \"amyloid\"[All Fields] OR \"amyloids\"[All Fields] OR \"amyloid\"[MeSH Terms] OR \"amyloidal\"[All Fields] OR \"amyloidic\"[All Fields] OR \"app protein human\"[Supplementary Concept] OR \"app protein human\"[All Fields] OR (\"transl androl urol\"[Journal] OR \"tau\"[All Fields]) OR (\"neuropathology\"[MeSH Terms] OR \"neuropathology\"[All Fields] OR \"neuropathologies\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 1, "ids": [ "42878653" ] }, "cochrane_glia_vascular_metabolic": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (microglia OR neuroinflamm* OR vascular OR metabolic) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"microglia\"[MeSH Terms] OR \"microglia\"[All Fields] OR \"microglias\"[All Fields] OR \"microglia s\"[All Fields] OR \"neuroinflamm*\"[All Fields] OR (\"blood vessels\"[MeSH Terms] OR (\"blood\"[All Fields] AND \"vessels\"[All Fields]) OR \"blood vessels\"[All Fields] OR \"vascular\"[All Fields] OR \"vascularisation\"[All Fields] OR \"neovascularization, pathologic\"[MeSH Terms] OR (\"neovascularization\"[All Fields] AND \"pathologic\"[All Fields]) OR \"pathologic neovascularization\"[All Fields] OR \"vascularization\"[All Fields] OR \"vascularisations\"[All Fields] OR \"vascularise\"[All Fields] OR \"vascularised\"[All Fields] OR \"vascularities\"[All Fields] OR \"vascularitis\"[All Fields] OR \"vascularity\"[All Fields] OR \"vascularizations\"[All Fields] OR \"vascularize\"[All Fields] OR \"vascularized\"[All Fields] OR \"vascularizes\"[All Fields] OR \"vascularizing\"[All Fields] OR \"vasculars\"[All Fields]) OR (\"metabolic\"[All Fields] OR \"metabolical\"[All Fields] OR \"metabolically\"[All Fields] OR \"metabolics\"[All Fields] OR \"metabolism\"[MeSH Terms] OR \"metabolism\"[All Fields] OR \"metabolisms\"[All Fields] OR \"metabolism\"[MeSH Subheading] OR \"metabolities\"[All Fields] OR \"metabolization\"[All Fields] OR \"metabolize\"[All Fields] OR \"metabolized\"[All Fields] OR \"metabolizer\"[All Fields] OR \"metabolizers\"[All Fields] OR \"metabolizes\"[All Fields] OR \"metabolizing\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 0, "ids": [] }, "cochrane_fluid_biomarkers": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (plasma OR blood OR cerebrospinal OR biomarker*) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"plasma\"[MeSH Terms] OR \"plasma\"[All Fields] OR \"plasmas\"[All Fields] OR \"plasma s\"[All Fields] OR (\"blood\"[MeSH Subheading] OR \"blood\"[All Fields] OR \"blood\"[MeSH Terms] OR \"bloods\"[All Fields] OR \"haematology\"[All Fields] OR \"hematology\"[MeSH Terms] OR \"hematology\"[All Fields] OR \"haematoma\"[All Fields] OR \"hematoma\"[MeSH Terms] OR \"hematoma\"[All Fields] OR \"haemorrhage\"[All Fields] OR \"hemorrhage\"[MeSH Terms] OR \"hemorrhage\"[All Fields] OR \"haemorrhages\"[All Fields] OR \"hemorrhages\"[All Fields] OR \"haemorrhagic\"[All Fields] OR \"haemorrhaging\"[All Fields] OR \"hematologies\"[All Fields] OR \"haematomas\"[All Fields] OR \"hematomas\"[All Fields] OR \"hematoma s\"[All Fields] OR \"hematomae\"[All Fields] OR \"hemorrhaged\"[All Fields] OR \"hemorrhagic\"[All Fields] OR \"hemorrhagical\"[All Fields] OR \"hemorrhaging\"[All Fields]) OR \"cerebrospinal\"[All Fields] OR \"biomarker*\"[All Fields]) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 0, "ids": [] }, "cochrane_imaging": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (PET OR MRI OR imaging OR atrophy) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"PET\"[All Fields] OR (\"magnetic resonance imaging\"[MeSH Terms] OR (\"magnetic\"[All Fields] AND \"resonance\"[All Fields] AND \"imaging\"[All Fields]) OR \"magnetic resonance imaging\"[All Fields] OR \"mri\"[All Fields]) OR (\"image s\"[All Fields] OR \"imaged\"[All Fields] OR \"imager\"[All Fields] OR \"imager s\"[All Fields] OR \"imagers\"[All Fields] OR \"images\"[All Fields] OR \"imaging\"[All Fields] OR \"imaging s\"[All Fields] OR \"imagings\"[All Fields] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[Supplementary Concept] OR \"intrauterine growth retardation metaphyseal dysplasia adrenal hypoplasia congenita and genital anomalies\"[All Fields] OR \"image\"[All Fields]) OR (\"atrophie\"[All Fields] OR \"atrophy\"[MeSH Terms] OR \"atrophy\"[All Fields] OR \"atrophied\"[All Fields] OR \"atrophies\"[All Fields] OR \"atrophying\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 1, "ids": [ "42878653" ] }, "cochrane_anti_amyloid": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (lecanemab OR donanemab OR antibody OR ARIA) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"lecanemab\"[Supplementary Concept] OR \"lecanemab\"[All Fields] OR (\"donanemab\"[Supplementary Concept] OR \"donanemab\"[All Fields]) OR (\"antibodie\"[All Fields] OR \"antibodies\"[Supplementary Concept] OR \"antibodies\"[All Fields] OR \"antibodies\"[MeSH Terms] OR \"antibody s\"[All Fields] OR \"antibodys\"[All Fields] OR \"immunoglobulins\"[Supplementary Concept] OR \"immunoglobulins\"[All Fields] OR \"antibody\"[All Fields] OR \"immunoglobulins\"[MeSH Terms]) OR (\"nrg1 protein human\"[Supplementary Concept] OR \"nrg1 protein human\"[All Fields] OR \"aria\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 1, "ids": [ "42878653" ] }, "cochrane_symptomatic_nps": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (cholinesterase OR memantine OR agitation OR psychosis OR sleep) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"cholinesterases\"[Supplementary Concept] OR \"cholinesterases\"[All Fields] OR \"cholinesterase\"[All Fields] OR \"cholinesterases\"[MeSH Terms] OR \"cholinesterasic\"[All Fields] OR (\"memantine\"[Supplementary Concept] OR \"memantine\"[All Fields] OR \"memantin\"[All Fields] OR \"memantine\"[MeSH Terms] OR \"memantine s\"[All Fields]) OR (\"agitate\"[All Fields] OR \"agitated\"[All Fields] OR \"agitates\"[All Fields] OR \"agitating\"[All Fields] OR \"agitation\"[All Fields] OR \"agitations\"[All Fields] OR \"agitator\"[All Fields] OR \"agitators\"[All Fields]) OR (\"psychotic disorders\"[MeSH Terms] OR (\"psychotic\"[All Fields] AND \"disorders\"[All Fields]) OR \"psychotic disorders\"[All Fields] OR \"psychosis\"[All Fields]) OR (\"sleep\"[MeSH Terms] OR \"sleep\"[All Fields] OR \"sleeping\"[All Fields] OR \"sleeps\"[All Fields] OR \"sleep s\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 0, "ids": [] }, "cochrane_prevention": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (prevention OR lifestyle OR exercise OR diet OR hearing) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"prevent\"[All Fields] OR \"preventability\"[All Fields] OR \"preventable\"[All Fields] OR \"preventative\"[All Fields] OR \"preventatively\"[All Fields] OR \"preventatives\"[All Fields] OR \"prevented\"[All Fields] OR \"preventing\"[All Fields] OR \"prevention and control\"[MeSH Subheading] OR (\"prevention\"[All Fields] AND \"control\"[All Fields]) OR \"prevention and control\"[All Fields] OR \"prevention\"[All Fields] OR \"prevention s\"[All Fields] OR \"preventions\"[All Fields] OR \"preventive\"[All Fields] OR \"preventively\"[All Fields] OR \"preventives\"[All Fields] OR \"prevents\"[All Fields] OR (\"life style\"[MeSH Terms] OR (\"life\"[All Fields] AND \"style\"[All Fields]) OR \"life style\"[All Fields] OR \"lifestyle\"[All Fields] OR \"lifestyles\"[All Fields]) OR (\"exercise\"[MeSH Terms] OR \"exercise\"[All Fields] OR \"exercises\"[All Fields] OR \"exercise therapy\"[MeSH Terms] OR (\"exercise\"[All Fields] AND \"therapy\"[All Fields]) OR \"exercise therapy\"[All Fields] OR \"exercising\"[All Fields] OR \"exercise s\"[All Fields] OR \"exercised\"[All Fields] OR \"exerciser\"[All Fields] OR \"exercisers\"[All Fields]) OR (\"diet\"[MeSH Terms] OR \"diet\"[All Fields]) OR (\"hearing\"[MeSH Terms] OR \"hearing\"[All Fields] OR \"hearings\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 0, "ids": [] }, "cochrane_care_patient": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (caregiv* OR care OR patient* OR stigma OR experience) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"caregiv*\"[All Fields] OR \"care\"[All Fields] OR \"patient*\"[All Fields] OR (\"social stigma\"[MeSH Terms] OR (\"social\"[All Fields] AND \"stigma\"[All Fields]) OR \"social stigma\"[All Fields] OR \"stigma\"[All Fields] OR \"stigmas\"[All Fields] OR \"stigma s\"[All Fields]) OR (\"experience\"[All Fields] OR \"experience s\"[All Fields] OR \"experiences\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 1, "ids": [ "42878653" ] }, "cochrane_guidelines_trials": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (guideline* OR consensus OR trial* OR treatment) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND (\"guideline*\"[All Fields] OR (\"consensual\"[All Fields] OR \"consensually\"[All Fields] OR \"consensus\"[MeSH Terms] OR \"consensus\"[All Fields]) OR \"trial*\"[All Fields] OR (\"therapeutics\"[MeSH Terms] OR \"therapeutics\"[All Fields] OR \"treatments\"[All Fields] OR \"therapy\"[MeSH Subheading] OR \"therapy\"[All Fields] OR \"treatment\"[All Fields] OR \"treatment s\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 0, "ids": [] }, "cochrane_ad_window": { "query": "\"Cochrane Database Syst Rev\"[jour] AND (Alzheimer* OR dementia) AND (\"2026/10/13\"[dp]:\"2026/10/20\"[dp])", "translation": "\"Cochrane Database Syst Rev\"[Journal] AND (\"alzheimer*\"[All Fields] OR (\"dementia\"[MeSH Terms] OR \"dementia\"[All Fields] OR \"dementias\"[All Fields] OR \"dementia s\"[All Fields])) AND 2026/10/13:2026/10/20[Date - Publication]", "count": 2, "ids": [ "42878653", "42878647" ] } }, "followup": { "diranersen_results": { "query": "diranersen OR BIIB080 OR IONIS-MAPTRx AND (Alzheimer*) AND (2026[dp])", "translation": "(\"diranersen\"[All Fields] OR \"BIIB080\"[All Fields]) AND \"alzheimer*\"[All Fields] AND 2026/01/01:2026/12/31[Date - Publication]", "count": 7, "ids": [ "42744164", "42702342", "42164617", "41964075", "41735150", "41702711", "41673497" ] }, "tau_personalized_endpoint": { "query": "(Alzheimer*[tiab]) AND (\"personalized composite\"[tiab] OR \"personalised composite\"[tiab] OR \"personalized cognitive composite\"[tiab] OR \"individualized cognitive\"[tiab] OR \"personalized cognitive endpoint*\"[tiab] OR \"tau-informed\"[tiab] OR \"patient-specific cognitive\"[tiab])", "translation": "\"alzheimer*\"[Title/Abstract] AND (\"individualized cognitive\"[Title/Abstract] OR \"tau-informed\"[Title/Abstract] OR \"patient-specific cognitive\"[Title/Abstract])", "count": 11, "ids": [ "42594414", "41962454", "41376794", "41322478", "38093572", "29439353", "28731452", "26572551", "24011983", "19183790", "16753587" ] }, "oq25_outcomes": { "query": "(Alzheimer*[tiab] OR \"Alzheimer Disease\"[mh]) AND (biomarker*[tiab] OR \"biological definition\"[tiab] OR disclosure[tiab]) AND (insurance[tiab] OR employment[tiab] OR \"legal capacity\"[tiab] OR \"legal-capacity\"[tiab]) AND (\"2024/01/01\"[dp]:\"2026/10/20\"[dp])", "translation": "(\"alzheimer*\"[Title/Abstract] OR \"Alzheimer Disease\"[MeSH Terms]) AND (\"biomarker*\"[Title/Abstract] OR \"biological definition\"[Title/Abstract] OR \"disclosure\"[Title/Abstract]) AND (\"insurance\"[Title/Abstract] OR \"employment\"[Title/Abstract] OR \"legal-capacity\"[Title/Abstract] OR \"legal-capacity\"[Title/Abstract]) AND 2024/01/01:2026/10/20[Date - Publication]", "count": 34, "ids": [ "42895756", "42626026", "42421820", "42418029", "42325223", "42255963", "41983466", "41950049", "41852591", "41804520", "41722593", "41644472", "41477735", "41445784", "41313603", "40825393", "40799724", "40768634", "40680346", "40656066", "40645733", "40207637", "40196631", "40092057", "39371133", "39361156", "39302379", "39261447", "38711561", "38393896", "38374734", "38109088", "38105531", "37832727" ] }, "oq27_treatment_experience": { "query": "(Alzheimer*[tiab]) AND (lecanemab[tiab] OR donanemab[tiab] OR \"anti-amyloid\"[tiab] OR ARIA[tiab]) AND (qualitative[tiab] OR interview*[tiab] OR \"lived experience\"[tiab] OR \"patient experience\"[tiab]) AND (\"2026/09/01\"[dp]:\"2026/10/20\"[dp])", "translation": "\"alzheimer*\"[Title/Abstract] AND (\"lecanemab\"[Title/Abstract] OR \"donanemab\"[Title/Abstract] OR \"anti-amyloid\"[Title/Abstract] OR \"ARIA\"[Title/Abstract]) AND (\"qualitative\"[Title/Abstract] OR \"interview*\"[Title/Abstract] OR \"lived experience\"[Title/Abstract] OR \"patient experience\"[Title/Abstract]) AND 2026/09/01:2026/10/20[Date - Publication]", "count": 0, "ids": [] }, "pending_molina": { "query": "42862590[pmid]", "translation": "42862590[UID]", "count": 1, "ids": [ "42862590" ] }, "pending_ataka": { "query": "42862138[pmid]", "translation": "42862138[UID]", "count": 1, "ids": [ "42862138" ] }, "pending_alten": { "query": "42855813[pmid]", "translation": "42855813[UID]", "count": 1, "ids": [ "42855813" ] } }, "europepmc": { "diagnosis_staging": { "query": "FIRST_PDATE:[2026-10-13 TO 2026-10-20] AND (TITLE_ABS:Alzheimer* OR TITLE_ABS:dementia) AND (diagnos* OR stag* OR criteria OR disclosure)", "count": 141, "pmid_ids": [ "42885674", "42880054", "42881403", "42873209", "42885682", "42876348", "42879726", "42888867", "42878653", "42891981", "42873489", "42887093", "42878155", "42879070", "42878527", "42868046", "42890838", "42864763", "42874246", "42874179", "42880791", "42874425", "42867534", "42867945", "42868090", "42874293", "42878651", "42867924", "42868044", "42874008", "42891615", "42888935", "42885693", "42891040", "42888346", "42879274", "42888381", "42892388", "42880559", "42875694", "42867198", "42880555", "42885481" ], "no_pmid": [ { "id": "PMC13666334", "pmid": null, "doi": null, "title": "Validation of the Shiraz Verbal Learning Test in elderly women, both with and without dementia Valida\u00e7\u00e3o do Teste de Aprendizagem Verbal de Shiraz em idosas com e sem dem\u00eancia", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PMC13676600", "pmid": null, "doi": null, "title": "Timing matters: a life-course review of midlife type 2 diabetes, exposure duration, and late-life dementia risk", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PMC13663878", "pmid": null, "doi": null, "title": "Nutritional intervention targeting muscle-brain axis in dementia continuum: from mechanisms to practice", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PMC13671975", "pmid": null, "doi": null, "title": "From empirical efficacy to neurovascular and cerebrovascular systems perspective: a bibliometric and visualized analysis of traditional Chinese medicine for vascular dementia", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PMC13665260", "pmid": null, "doi": null, "title": "Home health pathways relevant to Patient-Driven Groupings Model Classification Among Medicare Beneficiaries with and Without Dementia", "source": "PMC", "isOpenAccess": "N", "inEPMC": "Y" }, { "id": "PMC13668599", "pmid": null, "doi": null, "title": "Development of a multimodal health education module for dementia prevention in at-risk rural Indian elders: a SMRUTHI INDIA initiative", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PMC13655026", "pmid": null, "doi": null, "title": "Home-administered unfocused transcranial ultrasound in subjective cognitive decline and dementia: an open-label, uncontrolled feasibility pilot study", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PMC13669113", "pmid": null, "doi": null, "title": "Eye-movement-based machine learning for identifying Parkinson\u2019s disease dementia in a retrospective cohort: an interpretable model-development study", "source": 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"PPR", "isOpenAccess": "N", "inEPMC": "N" }, { "id": "PMC13655067", "pmid": null, "doi": null, "title": "Efficacy and safety of lecanemab monoclonal antibody in the treatment of mild to moderate Alzheimer\u2019s disease: a systematic review and meta-analysis", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PPR1340633", "pmid": null, "doi": "10.21203/rs.3.rs-10818940/v1", "title": "The Effect of Noncontingent Monetary Incentives in Recruitment Letters on Research Enrollment of Alzheimer\u2019s Disease and Related Dementia Caregiving Dyads: A Study Within a Trial (SWAT) Randomized Controlled Trial", "source": "PPR", "isOpenAccess": "N", "inEPMC": "N" }, { "id": "PMC13672516", "pmid": null, "doi": null, "title": "Safety of lecanemab in real-world patients with Alzheimer\u2019s disease: a prospective, observational case series supported by FAERS signal analysis", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PPR1343923", "pmid": null, "doi": 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{ "id": "PMC13656208", "pmid": null, "doi": null, "title": "Microbiota-derived metabolite signatures in Alzheimer\u2019s disease across the cognitive aging continuum: a human-focused systematic review and evidence-weighted knowledge graph", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PPR1342498", "pmid": null, "doi": "10.64898/2026.10.12.26365318", "title": "Turbulent dynamics and in silico perturbation-based measures are disrupted across biological stages of Alzheimers disease", "source": "PPR", "isOpenAccess": "N", "inEPMC": "N" }, { "id": "PMC13655124", "pmid": null, "doi": null, "title": "Association of temporal and masseter muscle thickness with cognitive function and clinical severity in Alzheimer\u2019s disease: a retrospective study", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PMC13669838", "pmid": null, "doi": null, "title": "The application progress of artificial intelligence in the diagnosis of Alzheimer\u2019s disease", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PMC13658621", "pmid": null, "doi": null, "title": "A pilot study of invasive vagus nerve stimulation in Chinese patients with Alzheimer\u2019s disease: preliminary results on safety, cognition, and biomarkers", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PMC13659920", "pmid": null, "doi": null, "title": "Potential links between PCOS/PMOS and Alzheimer disease and related dementias", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PMC13670211", "pmid": null, "doi": null, "title": "No evidence that serum metabolite slopes improve held-out prediction of clinical progression in the Alzheimer\u2019s disease neuroimaging initiative", "source": "PMC", "isOpenAccess": "Y", "inEPMC": "Y" }, { "id": "PMC13655240", "pmid": null, "doi": null, "title": "Immune-related molecular links between asthma and Alzheimer\u2019s disease identified by multi-omics, machine learning and single-cell analysis", "source": 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"2031-09", "primary_outcomes": [ "Positive predictive power of a biomarker or group of biomarkers", "Biomarkers obtained by blood draw, lumbar puncture, MRI, FDG PET, PET amyloid imaging", "Clinical markers also examined from clinical interview and cognitive testing" ] }, { "id": "NCT00898807", "verified_id": "NCT00898807", "status": "COMPLETED", "last_update_posted": "2014-06-27", "results_posted": "2014-06-27", "has_results": true, "title": "Citalopram for Agitation in Alzheimer's Disease", "status_verified": "2014-06", "primary_completion": "2013-09", "enrollment": 186, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2009-07", "completion_date": "2013-09", "primary_outcomes": [ "NeuroBehavior Rating Scale-- Agitation", "Modified Alzheimer's Disease Cooperative Study- Clinical Global Impression of Change in Agitation(CGIC)" ] }, { "id": "NCT01041989", "verified_id": "NCT01041989", "status": "UNKNOWN", "last_update_posted": "2023-04-19", "results_posted": null, "has_results": false, "title": "Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability", "status_verified": "2023-04", "primary_completion": "2013-12", "enrollment": 1200, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2009-09", "completion_date": "2025-12", "primary_outcomes": [ "Cognitive impairment assessed with a Neuropsychological Test Battery, and Stroop and Trail Making tests." ] }, { "id": "NCT01206062", "verified_id": "NCT01206062", "status": "COMPLETED", "last_update_posted": "2021-01-08", "results_posted": "2017-12-04", "has_results": true, "title": "Systolic Blood Pressure Intervention Trial", "status_verified": "2020-12", "primary_completion": "2016-07", "enrollment": 9361, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2010-10", "completion_date": "2019-03", "primary_outcomes": [ "Number of Participants With First Occurrence of a Myocardial Infarction (MI), Acute Coronary Syndrome (ACS), Stroke, Heart Failure (HF), or CVD Death" ] }, { "id": "NCT01584440", "verified_id": "NCT01584440", "status": "COMPLETED", "last_update_posted": "2021-11-26", "results_posted": "2021-11-26", "has_results": true, "title": "Efficacy, Safety and Tolerability Study of AVP-923 (Dextromethorphan/Quinidine) for Treatment of Symptoms of Agitation in Participants With Alzheimer's Disease", "status_verified": "2021-10", "primary_completion": "2014-07-30", "enrollment": 220, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2012-08-13", "completion_date": "2014-07-30", "primary_outcomes": [ "Change in the Neuropsychiatric Inventory (NPI) Agitation/Aggression Domain Score From Day 1 (Stage 1 Baseline) to Day 36 (Stage 2 Baseline) and From Day 36 to Day 70" ] }, { "id": "NCT01739348", "verified_id": "NCT01739348", "status": "TERMINATED", "last_update_posted": "2018-10-24", "results_posted": "2018-05-16", "has_results": true, "title": "An Efficacy and Safety Trial of Verubecestat (MK-8931) in Mild to Moderate Alzheimer's Disease (P07738)", "status_verified": "2018-09", "primary_completion": "2017-04-14", "enrollment": 2211, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2012-11-30", "completion_date": "2017-04-14", "primary_outcomes": [ "[Part I (Base Study)] Change From Baseline in the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) Score", "[Part I (Base Study)] Change From Baseline in Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) Score", "[Part II (Extension Study)] Change From Baseline in Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) Score", "[Part II (Extension Study)] Change From Baseline in Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL) Score", "[Part I (Base Study)] Number of Participants Who Experienced an Adverse Event" ] }, { "id": "NCT01760005", "verified_id": "NCT01760005", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-07-27", "results_posted": null, "has_results": false, "title": "Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001", "status_verified": "2026-07", "primary_completion": "2028-04", "enrollment": 490, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2012-12", "completion_date": "2028-07", "primary_outcomes": [ "Assess cognitive efficacy in individuals with mutations causing dominantly inherited AD as measured by the change from baseline in the DIAN-Multivariate Cognitive Endpoint (DIAN-MCE)" ] }, { "id": "NCT01843075", "verified_id": "NCT01843075", "status": "UNKNOWN", "last_update_posted": "2019-06-10", "results_posted": null, "has_results": false, "title": "Evaluating Liraglutide in Alzheimer's Disease", "status_verified": "2019-06", "primary_completion": "2019-12", "enrollment": 204, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2014-01", "completion_date": "2019-12", "primary_outcomes": [ "The change in cerebral glucose metabolic rate" ] }, { "id": "NCT01900665", "verified_id": "NCT01900665", "status": "TERMINATED", "last_update_posted": "2019-10-09", "results_posted": "2018-03-14", "has_results": true, "title": "Progress of Mild Alzheimer's Disease in Participants on Solanezumab Versus Placebo", "status_verified": "2019-09", "primary_completion": "2016-10", "enrollment": 2129, "enrollment_type": "ACTUAL", "why_stopped": "Solanezumab did not meet the study's primary endpoint.", "start_date": "2013-07", "completion_date": "2017-02", "primary_outcomes": [ "Change From Baseline in Alzheimer's Disease Assessment Scale-Cognitive 14 Item Subscore (ADAS-Cog14)" ] }, { "id": "NCT01953601", "verified_id": "NCT01953601", "status": "TERMINATED", "last_update_posted": "2019-05-17", "results_posted": "2019-05-17", "has_results": true, "title": "Efficacy and Safety Trial of Verubecestat (MK-8931) in Participants With Prodromal Alzheimer's Disease (MK-8931-019)", "status_verified": "2019-05", "primary_completion": "2018-04-17", "enrollment": 1454, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2013-11-05", "completion_date": "2018-04-17", "primary_outcomes": [ "Part 1 (Base Study). Least Squares Mean (LSM) Change From Baseline in Clinical Dementia Rating Sum of Boxes (CDR-SB) Score at Week 104", "Part 2 (Extension Study). Mean Change From Baseline in Clinical Dementia Rating Sum of Boxes (CDR-SB) Score at Week 130", "Part 1 (Base Study). Percentage of Participants Who Experienced \u22651 Adverse Event (AE)", "Part 1 (Base Study). Percentage of Participants Who Discontinued From Study Drug Due to an Adverse Event (AE)", "Part 2 (Extension Study). Percentage of Participants Who Experienced \u22651 Adverse Event (AE)" ] }, { "id": "NCT02008357", "verified_id": "NCT02008357", "status": "COMPLETED", "last_update_posted": "2026-08-21", "results_posted": "2023-12-28", "has_results": true, "title": "Clinical Trial of Solanezumab for Older Individuals Who May be at Risk for Memory Loss", "status_verified": "2026-08", "primary_completion": "2022-12-27", "enrollment": 1169, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2014-02-28", "completion_date": "2023-06-08", "primary_outcomes": [ "Change From Baseline of the Preclinical Alzheimer Cognitive Composite (PACC) Score", "Change From Baseline of the Preclinical Alzheimer Cognitive Composite (PACC) Score" ] }, { "id": "NCT02346201", "verified_id": "NCT02346201", "status": "COMPLETED", "last_update_posted": "2023-06-13", "results_posted": "2023-06-13", "has_results": true, "title": "Apathy in Dementia Methylphenidate Trial 2", "status_verified": "2023-06", "primary_completion": "2020-07-15", "enrollment": 200, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2016-01", "completion_date": "2020-07-15", "primary_outcomes": [ "Neuropsychiatric Inventory (NPI)", "Percentage of Participants With Change in Modified Alzheimer's Disease Cooperative Study- Clinical Global Impression of Change (CGIC)" ] }, { "id": "NCT03108846", "verified_id": "NCT03108846", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2025-01-31", "results_posted": null, "has_results": false, "title": "Escitalopram for Agitation in Alzheimer's Disease", "status_verified": "2025-01", "primary_completion": "2024-04-05", "enrollment": 187, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2018-01-03", "completion_date": "2025-05", "primary_outcomes": [ "modified- Alzheimer's Disease Cooperative Study--Clinical Global Impression of Change (mADCS-CGIC)" ] }, { "id": "NCT03186989", "verified_id": "NCT03186989", "status": "COMPLETED", "last_update_posted": "2025-04-08", "results_posted": "2025-04-08", "has_results": true, "title": "Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS-MAPTRx in Patients With Mild Alzheimer's Disease", "status_verified": "2025-03", "primary_completion": "2022-05-12", "enrollment": 46, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2017-10-12", "completion_date": "2022-05-12", "primary_outcomes": [ "Part 1: Number of Participants With Adverse Events That Are Related to Treatment With ISIS 814907", "Part 2: Number of Participants With Adverse Events That Are Related to Treatment With ISIS 814907" ] }, { "id": "NCT03243422", "verified_id": "NCT03243422", "status": "COMPLETED", "last_update_posted": "2024-02-01", "results_posted": "2024-02-01", "has_results": true, "title": "Aging and Cognitive Health Evaluation in Elders (ACHIEVE)", "status_verified": "2024-01", "primary_completion": "2022-11-30", "enrollment": 977, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2018-01-04", "completion_date": "2023-06-12", "primary_outcomes": [ "Change in Global Cognitive Function" ] }, { "id": "NCT03289143", "verified_id": "NCT03289143", "status": "TERMINATED", "last_update_posted": "2022-03-16", "results_posted": "2022-03-16", "has_results": true, "title": "A Study to Evaluate the Efficacy and Safety of Semorinemab in Patients With Prodromal to Mild Alzheimer's Disease", "status_verified": "2022-02", "primary_completion": "2021-01-15", "enrollment": 457, "enrollment_type": "ACTUAL", "why_stopped": "Study was terminated during Open Label Extension period because analyses of placebo-controlled Blinded portion of study did not show any evidence of clinical efficacy or modulation of accumulation of tau PET signal at any of the doses studied.", "start_date": "2017-10-04", "completion_date": "2021-01-15", "primary_outcomes": [ "Change From Baseline on the CDR-SB", "Percentage of Participants With Adverse Events", "Change From Baseline on the C-SSRS", "Other Abnormal MRI Findings" ] }, { "id": "NCT03325556", "verified_id": "NCT03325556", "status": "COMPLETED", "last_update_posted": "2021-06-21", "results_posted": "2021-06-21", "has_results": true, "title": "Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis", "status_verified": "2021-05", "primary_completion": "2019-07-31", "enrollment": 392, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2017-09-27", "completion_date": "2019-10-30", "primary_outcomes": [ "Time From Randomization to Relapse in the Double-blind (DB) Period" ] }, { "id": "NCT03352557", "verified_id": "NCT03352557", "status": "TERMINATED", "last_update_posted": "2022-11-08", "results_posted": "2022-11-08", "has_results": true, "title": "Phase 2 Study of BIIB092 in Participants With Early Alzheimer's Disease", "status_verified": "2022-10", "primary_completion": "2021-08-30", "enrollment": 654, "enrollment_type": "ACTUAL", "why_stopped": "The study (NCT03352557) was terminated based on lack of efficacy following the placebo-controlled period readout.", "start_date": "2018-05-03", "completion_date": "2021-08-30", "primary_outcomes": [ "PC Period: Percentage of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)", "LTE Period: Percentage of Participants With AEs and SAEs" ] }, { "id": "NCT03367403", "verified_id": "NCT03367403", "status": "COMPLETED", "last_update_posted": "2026-03-19", "results_posted": "2022-02-15", "has_results": true, "title": "A Study of LY3002813 in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ)", "status_verified": "2022-09", "primary_completion": "2020-12-04", "enrollment": 272, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2017-12-18", "completion_date": "2021-09-21", "primary_outcomes": [ "Change From Baseline in the Integrated Alzheimer's Disease Rating Scale (iADRS) Score" ] }, { "id": "NCT03443973", "verified_id": "NCT03443973", "status": "TERMINATED", "last_update_posted": "2024-01-17", "results_posted": "2024-01-17", "has_results": true, "title": "Safety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)", "status_verified": "2023-12", "primary_completion": "2022-09-23", "enrollment": 975, "enrollment_type": "ACTUAL", "why_stopped": "Decision to terminate development of Gantenerumab for treatment of prodromal/mild/early stage Alzheimer's disease following results of a pre-planned analysis of the safety and efficacy of Gant in Graduate I\\&II (WN29922/WN39658).", "start_date": "2018-08-22", "completion_date": "2022-11-28", "primary_outcomes": [ "DBT Period: Change From Baseline to Week 116 in Global Outcome, as Measured by CDR-SB", "OLE Period: Number of Participants With Adverse Events (AEs)", "OLE Period: Number of Participants With Post-baseline Suicidal Ideation or Suicidal Behavior as Measured Using Columbia-Suicide Severity Rating Scale (C-SSRS)", "OLE Period : Number of Participants With Amyloid-Related Imaging Abnormalities-Haemosiderin Deposition (ARIA-H) Confirmed by MRI", "OLE Period: Number of Participants With Amyloid-Related Imaging Abnormalities-Edema (ARIA-E) Confirmed by Magnetic Resonance Imaging (MRI)" ] }, { "id": "NCT03444870", "verified_id": "NCT03444870", "status": "TERMINATED", "last_update_posted": "2024-01-30", "results_posted": "2024-01-30", "has_results": true, "title": "Efficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)", "status_verified": "2024-01", "primary_completion": "2022-12-28", "enrollment": 1053, "enrollment_type": "ACTUAL", "why_stopped": "Decision to terminate development of Gantenerumab for treatment of prodromal/mild/early-stage Alzheimer's disease following results of a pre-planned analysis of the safety and efficacy of Gant in Graduate I\\&II (WN29922/WN39658).", "start_date": "2018-06-06", "completion_date": "2023-02-17", "primary_outcomes": [ "DBT Period: Change From Baseline to Week 116 in Global Outcome, as Measured by CDR-SB", "China Extension: DBT Period: Change From Baseline to Week 116 in Global Outcome, as Measured by CDR-SB" ] }, { "id": "NCT03446001", "verified_id": "NCT03446001", "status": "COMPLETED", "last_update_posted": "2025-09-04", "results_posted": "2025-09-04", "has_results": true, "title": "Safety and Efficacy of TRx0237 in Subjects With Alzheimer's Disease Followed by Open-Label Treatment", "status_verified": "2025-08", "primary_completion": "2022-03-31", "enrollment": 598, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2017-12-01", "completion_date": "2023-04-04", "primary_outcomes": [ "Change From Baseline on Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog11) (16 mg/Day vs Control)", "Change From Baseline on Alzheimer's Disease Cooperative Study - Activities of Daily Living (ADCS-ADL23) (16 mg/Day vs Control)", "Number of Study Participants With Serious and Non-serious Adverse Events (16 mg/Day vs Control)" ] }, { "id": "NCT03548584", "verified_id": "NCT03548584", "status": "COMPLETED", "last_update_posted": "2023-09-18", "results_posted": "2023-09-18", "has_results": true, "title": "A Trial to Evaluate the Safety, Efficacy, and Tolerability of Brexpiprazole in Treating Agitation Associated With Dementia of the Alzheimer's Type", "status_verified": "2023-09", "primary_completion": "2022-05-23", "enrollment": 345, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2018-05-16", "completion_date": "2022-06-01", "primary_outcomes": [ "Change From Baseline to Week 12 in the CMAI Total Score" ] }, { "id": "NCT03688126", "verified_id": "NCT03688126", "status": "COMPLETED", "last_update_posted": "2025-11-03", "results_posted": null, "has_results": false, "title": "U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk", "status_verified": "2025-01", "primary_completion": "2025-05-16", "enrollment": 2000, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2019-01-08", "completion_date": "2025-05-16", "primary_outcomes": [ "Global cognitive function composite score" ] }, { "id": "NCT03786471", "verified_id": "NCT03786471", "status": "COMPLETED", "last_update_posted": "2025-01-30", "results_posted": "2025-01-30", "has_results": true, "title": "D-CARE - The Dementia Care Study: A Pragmatic Clinical Trial of Health System-Based Versus Community-Based Dementia Care", "status_verified": "2025-01", "primary_completion": "2023-08-21", "enrollment": 2176, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2019-06-28", "completion_date": "2023-08-21", "primary_outcomes": [ "Severity of Dementia-related Behavioral Symptoms", "Severity of Dementia-related Behavioral Symptoms", "Severity of Dementia-related Behavioral Symptoms", "Severity of Dementia-related Behavioral Symptoms", "Severity of Dementia-related Behavioral Symptoms" ] }, { "id": "NCT03887455", "verified_id": "NCT03887455", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-10-06", "results_posted": null, "has_results": false, "title": "A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease", "status_verified": "2026-03", "primary_completion": "2026-12-31", "enrollment": 1906, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2019-03-27", "completion_date": "2026-12-31", "primary_outcomes": [ "Core Study: Change from Baseline in the CDR-SB at 18 Months", "Extension Phase: Number of Participants Reporting One or More Treatment-emergent Adverse Events (TEAEs)", "Extension Phase: Change from Core Study Baseline in CDR-SB", "Extension Phase Part B: Number of Participants Exposed to Lecanemab" ] }, { "id": "NCT04314934", "verified_id": "NCT04314934", "status": "COMPLETED", "last_update_posted": "2024-08-12", "results_posted": null, "has_results": false, "title": "OLE of Phase 2b/3 Study ANAVEX2-73-AD-004", "status_verified": "2024-08", "primary_completion": "2024-06-14", "enrollment": 300, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2019-10-10", "completion_date": "2024-06-14", "primary_outcomes": [ "Number of participants with treatment-related adverse events as assessed by CTCAE v4.03" ] }, { "id": "NCT04437511", "verified_id": "NCT04437511", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-08-26", "results_posted": "2024-05-20", "has_results": true, "title": "A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)", "status_verified": "2026-08", "primary_completion": "2023-04-14", "enrollment": 1736, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2020-06-19", "completion_date": "2028-11", "primary_outcomes": [ "Change From Baseline on the Integrated Alzheimer's Disease Rating Scale (iADRS) (Overall Population)", "Change From Baseline on the Integrated Alzheimer's Disease Rating Scale (iADRS) (Intermediate (Low-medium) Tau Population)" ] }, { "id": "NCT04468659", "verified_id": "NCT04468659", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-06-04", "results_posted": null, "has_results": false, "title": "AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid", "status_verified": "2026-06", "primary_completion": "2028-12-21", "enrollment": 1400, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2020-07-14", "completion_date": "2031-01-16", "primary_outcomes": [ "A45 Trial: Change From Baseline in Preclinical Alzheimer Cognitive Composite 5 (PACC5) Score at Week 216", "A3 Trial: Change From Baseline in Amyloid Positron Emission Tomography (PET) Standard Uptake Value Ratio (SUVr) at Week 216" ] }, { "id": "NCT04592874", "verified_id": "NCT04592874", "status": "COMPLETED", "last_update_posted": "2025-10-29", "results_posted": "2025-10-29", "has_results": true, "title": "A Phase 2 Study to Evaluate Efficacy and Safety of AL002 in Participants With Early Alzheimer's Disease", "status_verified": "2025-08", "primary_completion": "2024-08-19", "enrollment": 356, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2021-01-22", "completion_date": "2024-09-12", "primary_outcomes": [ "Disease Progression as Measured by the Clinical Dementia Rating - Sum of Boxes (CDR-SB) Score" ] }, { "id": "NCT04639050", "verified_id": "NCT04639050", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-09-14", "results_posted": null, "has_results": false, "title": "Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease", "status_verified": "2026-09", "primary_completion": "2027-07-31", "enrollment": 241, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2021-03-15", "completion_date": "2027-07-31", "primary_outcomes": [ "Part 1, 2, 3, and 4: Percentage of Participants With Adverse Events (AEs)", "Part 3: Change From Baseline in Brain Amyloid Load as Measured by Amyloid Positron Emission Tomography (PET) Scan" ] }, { "id": "NCT04770220", "verified_id": "NCT04770220", "status": "COMPLETED", "last_update_posted": "2026-09-29", "results_posted": "2025-11-10", "has_results": true, "title": "An Efficacy and Safety Study of ALZ-801 in APOE4/4 Early AD Subjects", "status_verified": "2026-09", "primary_completion": "2024-05-29", "enrollment": 325, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2021-05-19", "completion_date": "2024-07-29", "primary_outcomes": [ "Primary Cognitive Efficacy Endpoint (ADAS-Cog13)", "Incidence, Nature, and Severity of Treatment Emergent Adverse Events (TEAE)" ] }, { "id": "NCT04777396", "verified_id": "NCT04777396", "status": "COMPLETED", "last_update_posted": "2026-07-07", "results_posted": null, "has_results": false, "title": "A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)", "status_verified": "2026-07", "primary_completion": "2025-09-16", "enrollment": 1840, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2021-05-18", "completion_date": "2026-01-30", "primary_outcomes": [ "Change in the Clinical Dementia Rating - Sum of Boxes (CDR-SB) score" ] }, { "id": "NCT04777409", "verified_id": "NCT04777409", "status": "COMPLETED", "last_update_posted": "2026-06-26", "results_posted": null, "has_results": false, "title": "A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)", "status_verified": "2026-06", "primary_completion": "2025-09-15", "enrollment": 1840, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2021-05-18", "completion_date": "2026-01-30", "primary_outcomes": [ "Change in the Clinical Dementia Rating - Sum of Boxes (CDR-SB) score" ] }, { "id": "NCT05026866", "verified_id": "NCT05026866", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-01-21", "results_posted": null, "has_results": false, "title": "A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer's Disease (TRAILBLAZER-ALZ 3)", "status_verified": "2026-01", "primary_completion": "2027-11", "enrollment": 2996, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2021-08-27", "completion_date": "2027-11", "primary_outcomes": [ "Time to Clinical Progression of Composite Endpoint as Measured by Clinical Dementia Rating (CDR) in the Primary Study Population (Baseline CDR-Global Score [GS 0])" ] }, { "id": "NCT05108922", "verified_id": "NCT05108922", "status": "COMPLETED", "last_update_posted": "2024-11-29", "results_posted": "2023-11-02", "has_results": true, "title": "A Study of Donanemab (LY3002813) Compared With Aducanumab in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 4)", "status_verified": "2024-11", "primary_completion": "2022-09-09", "enrollment": 148, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2021-11-16", "completion_date": "2023-09-19", "primary_outcomes": [ "Percentage of Participants Who Reach Complete Amyloid Plaque Clearance on Florbetapir F18 Positron Emission Tomography (PET) Scan (Superiority) on Donanemab Versus Aducanumab", "Percentage of Participants Who Reach Complete Amyloid Plaque Clearance on Florbetapir F18 PET Scan in the Low/Medium (Intermediate) Subpopulation (Superiority) on Donanemab Versus Aducanumab" ] }, { "id": "NCT05399888", "verified_id": "NCT05399888", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-06-30", "results_posted": null, "has_results": false, "title": "A Study to Learn About the Safety of Diranersen (BIIB080) Injections and Whether They Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age", "status_verified": "2026-06", "primary_completion": "2026-03-11", "enrollment": 416, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2022-08-24", "completion_date": "2028-06-06", "primary_outcomes": [ "Dose response in Change From Baseline to Week 76 on the CDR-SB" ] }, { "id": "NCT05552157", "verified_id": "NCT05552157", "status": "RECRUITING", "last_update_posted": "2026-07-27", "results_posted": null, "has_results": false, "title": "A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation", "status_verified": "2026-07", "primary_completion": "2034-03-30", "enrollment": 280, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2024-11-22", "completion_date": "2034-08-30", "primary_outcomes": [ "Stage 1: Evaluate the ability of study drug to prevent or slow the rate of A\u03b2 accumulation compared with placebo in participants with mutations that cause DIAD", "Stage 2: Evaluate the effect of anti-amyloid treatment on downstream biomarkers of AD" ] }, { "id": "NCT05738486", "verified_id": "NCT05738486", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-06-18", "results_posted": "2025-11-14", "has_results": true, "title": "A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)", "status_verified": "2025-10", "primary_completion": "2024-05-16", "enrollment": 1175, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2023-02-28", "completion_date": "2027-05", "primary_outcomes": [ "Percentage of Participants With Any Occurrence of Amyloid-Related Imaging Abnormality-Edema/Effusion (ARIA-E)" ] }, { "id": "NCT05999084", "verified_id": "NCT05999084", "status": "ENROLLING_BY_INVITATION", "last_update_posted": "2026-07-10", "results_posted": null, "has_results": false, "title": "Georgia Memory Net Anti-Amyloid Monoclonal Antibody Registry", "status_verified": "2026-07", "primary_completion": "2028-07", "enrollment": 735, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2025-03-06", "completion_date": "2028-07", "primary_outcomes": [ "Change in Quick Dementia Rating System (QDRS) Score", "Montreal Cognitive Assessment (MoCA) Score", "Change in Functional Activities Questionnaire (FAQ) Score", "Change in Lawton-Brody Activities of Daily Living (ADL) Physical Self-Maintenance Scale (PSMS) Score", "Change in Lawton-Brody Instrumental Activities of Daily Living (IADL) Scale Score" ] }, { "id": "NCT06072963", "verified_id": "NCT06072963", "status": "RECRUITING", "last_update_posted": "2026-07-27", "results_posted": null, "has_results": false, "title": "COMMETS- Combination MCI Metabolic Syndrome", "status_verified": "2026-07", "primary_completion": "2027-12-01", "enrollment": 80, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2024-01-30", "completion_date": "2028-12-01", "primary_outcomes": [ "Cognitive change - The effect of the combination of Semaglutide and intranasal insulin on cognitive functioning.", "Neuroimaging outcome -- The effect of the combination of Semaglutide and intranasal insulin on cerebral blood flow (CBF).", "Neuroimaging outcome -- The effect of the combination of Semaglutide and intranasal insulin on brain glucose intake." ] }, { "id": "NCT06384573", "verified_id": "NCT06384573", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-07-27", "results_posted": null, "has_results": false, "title": "DIAN-TU Amyloid Removal Trial (ART) in Dominantly Inherited Alzheimer's Disease", "status_verified": "2026-07", "primary_completion": "2030-06", "enrollment": 40, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2024-06-10", "completion_date": "2030-06", "primary_outcomes": [ "The primary endpoint for the final analysis is the time to recurrent progression of Clinical Dementia Rating - Sum of Boxes (CDR-SB)." ] }, { "id": "NCT06424236", "verified_id": "NCT06424236", "status": "TERMINATED", "last_update_posted": "2025-02-04", "results_posted": "2025-02-04", "has_results": true, "title": "Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation", "status_verified": "2025-01", "primary_completion": "2023-10-06", "enrollment": 73, "enrollment_type": "ACTUAL", "why_stopped": "DIAN-TU announced the discontinuation of the DIAN-TU-001 OLE based on the status of the drug program and findings from an interim efficacy analysis and.", "start_date": "2020-06-03", "completion_date": "2023-11-13", "primary_outcomes": [ "Change From Baseline in Composite [11C] Pittsburgh Compound B (PiB)-Positron Emission Tomography (PET) Composite Standardized Uptake Value Ratio (C-SUVR) at Weeks 52, 104 and 156" ] }, { "id": "NCT06566170", "verified_id": "NCT06566170", "status": "RECRUITING", "last_update_posted": "2026-10-16", "results_posted": null, "has_results": false, "title": "A Real-World Comparative Study of Donanemab (LY3002813) Plus Usual Care Versus Usual Care Alone in US Participants With Early Symptomatic Alzheimer's Disease", "status_verified": "2026-10", "primary_completion": "2033-02", "enrollment": 6250, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2024-10-07", "completion_date": "2033-02", "primary_outcomes": [ "Time to First Increase in Dependence Level Above Baseline (as derived from the Dependence Scale [DS])" ] }, { "id": "NCT06602258", "verified_id": "NCT06602258", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-02-11", "results_posted": null, "has_results": false, "title": "A Study of E2814 With Concurrent Lecanemab Treatment in Participants With Early Alzheimer's Disease", "status_verified": "2026-01", "primary_completion": "2026-12-03", "enrollment": 105, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2024-09-30", "completion_date": "2027-08-18", "primary_outcomes": [ "Change From Baseline in CSF MTBR-tau-243 at 6 Months" ] }, { "id": "NCT06647498", "verified_id": "NCT06647498", "status": "RECRUITING", "last_update_posted": "2026-07-27", "results_posted": null, "has_results": false, "title": "A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation", "status_verified": "2026-07", "primary_completion": "2034-03", "enrollment": 280, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2024-11-22", "completion_date": "2034-08", "primary_outcomes": [ "Stage 1: Change in amyloid load as measured by centiloid (CL) [11C]PiB-PET as biomarker endpoint for DIAN-TU-002 remternetug arm" ] }, { "id": "NCT06653153", "verified_id": "NCT06653153", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-10-07", "results_posted": null, "has_results": false, "title": "A Study of Remternetug (LY3372993) in Early Alzheimer's Disease (TRAILRUNNER-ALZ 3)", "status_verified": "2026-10", "primary_completion": "2029-04", "enrollment": 1400, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2024-10-24", "completion_date": "2030-10", "primary_outcomes": [ "Time to Clinically Meaningful Progression as Measured by Clinical Dementia Rate Scale (CDR)" ] }, { "id": "NCT06889818", "verified_id": "NCT06889818", "status": "RECRUITING", "last_update_posted": "2025-03-21", "results_posted": null, "has_results": false, "title": "Korean Joint Registry for Alzheimer's Treatment and Diagnostics (JOY-ALZ)", "status_verified": "2025-02", "primary_completion": "2034-12-31", "enrollment": 4000, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2025-02-24", "completion_date": "2034-12-31", "primary_outcomes": [ "Change from baseline in the Korean Mini-Mental State Examination-2 (K-MMSE-2) total score", "Change from baseline in the Korean version of Montreal Cognitive Assessment (K-MOCA) total score", "Change from baseline in the Clinical Dementia Rating scale (CDR) total score", "Change from baseline in the Functional Assessment Questionnaire (FAQ) total score", "Change from baseline in the Korean version of the Alzheimer disease 8 (K-AD8) total score" ] }, { "id": "NCT06957418", "verified_id": "NCT06957418", "status": "RECRUITING", "last_update_posted": "2026-09-08", "results_posted": null, "has_results": false, "title": "Alzheimer's Tau Platform: Master Protocol", "status_verified": "2026-09", "primary_completion": "2028-08-31", "enrollment": 900, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2026-07-06", "completion_date": "2028-08-31", "primary_outcomes": [ "Reduction of brain tau deposition as measured by tau positron emission tomography (PET)" ] }, { "id": "NCT06996730", "verified_id": "NCT06996730", "status": "RECRUITING", "last_update_posted": "2026-09-02", "results_posted": null, "has_results": false, "title": "A Study of Donanemab, RG6289, or the Combination of Donanemab and RG6289 in Presenilin 1 (PSEN1) E280A Mutation Carriers for the Treatment of Autosomal-Dominant Alzheimer's Disease", "status_verified": "2026-08", "primary_completion": "2030-06-01", "enrollment": 240, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2026-07-08", "completion_date": "2030-06-01", "primary_outcomes": [ "Part 1: Change in amyloid load as measured by centiloid (CL) [F18]Florbetapir-PET as biomarker endpoint", "Part 2: Maintenance of Low Levels of Brain Amyloid as Measured by centiloid (Cl) [F18]Florbetapir-PET Following Combined Intervention of Donanemab and RG6289" ] }, { "id": "NCT07142954", "verified_id": "NCT07142954", "status": "RECRUITING", "last_update_posted": "2026-07-07", "results_posted": null, "has_results": false, "title": "Epidemiology and Biomarker Study in Alzheimer's Disease", "status_verified": "2026-07", "primary_completion": "2033-07", "enrollment": 3400, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2025-08-25", "completion_date": "2033-07", "primary_outcomes": [ "Time to Cognitive Worsening Within Cohorts as Measured by Cognitive Composite or Any of the Individual Composite Components" ] }, { "id": "NCT07158905", "verified_id": "NCT07158905", "status": "RECRUITING", "last_update_posted": "2026-08-21", "results_posted": null, "has_results": false, "title": "AV-1980R (Tau Vaccine) in Preclinical Alzheimer's Disease (TAURUS-1980)", "status_verified": "2026-07", "primary_completion": "2029-06-15", "enrollment": 48, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2026-06-23", "completion_date": "2029-10-15", "primary_outcomes": [ "Number of Participants with Treatment-Emergent Adverse Events and Serious Adverse Events" ] }, { "id": "NCT07167966", "verified_id": "NCT07167966", "status": "ENROLLING_BY_INVITATION", "last_update_posted": "2026-09-08", "results_posted": null, "has_results": false, "title": "Alzheimer's Tau Platform: Regimen A - AADvac1", "status_verified": "2026-09", "primary_completion": "2028-08-31", "enrollment": 450, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2026-11-03", "completion_date": "2028-08-31", "primary_outcomes": [ "Reduction of brain tau deposition as measured by tau positron emission tomography (PET)" ] }, { "id": "NCT07169578", "verified_id": "NCT07169578", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-09-25", "results_posted": null, "has_results": false, "title": "A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease", "status_verified": "2026-09", "primary_completion": "2028-02-16", "enrollment": 1101, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2025-09-17", "completion_date": "2028-02-16", "primary_outcomes": [ "Change From Baseline to Week 72 in Clinical Dementia Rating, Sum of Boxes (CDR-SB)" ] }, { "id": "NCT07170150", "verified_id": "NCT07170150", "status": "ACTIVE_NOT_RECRUITING", "last_update_posted": "2026-09-25", "results_posted": null, "has_results": false, "title": "A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease", "status_verified": "2026-09", "primary_completion": "2028-02-16", "enrollment": 1060, "enrollment_type": "ACTUAL", "why_stopped": null, "start_date": "2025-11-12", "completion_date": "2028-02-16", "primary_outcomes": [ "Change From Baseline to Week 72 in Clinical Dementia Rating, Sum of Boxes (CDR-SB)" ] }, { "id": "NCT07651319", "verified_id": "NCT07651319", "status": "RECRUITING", "last_update_posted": "2026-09-23", "results_posted": null, "has_results": false, "title": "Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease", "status_verified": "2026-09", "primary_completion": "2029-06", "enrollment": 30, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2026-09-01", "completion_date": "2029-12", "primary_outcomes": [ "Safety and the tolerability of IL-2 plus Semaglutide in AD patients" ] }, { "id": "NCT07717411", "verified_id": "NCT07717411", "status": "RECRUITING", "last_update_posted": "2026-10-13", "results_posted": null, "has_results": false, "title": "A Study of Trontinemab in Cognitively Unimpaired Individuals at Risk for Progression to Symptomatic Alzheimer's Disease", "status_verified": "2026-10", "primary_completion": "2032-09-03", "enrollment": 1600, "enrollment_type": "ESTIMATED", "why_stopped": null, "start_date": "2026-11-30", "completion_date": "2032-09-03", "primary_outcomes": [ "Time to Progression, defined as confirmed Clinical Dementia Rating - Global Score (CDR-GS) > 0" ] } ], "registry_extra": { "ctgov_tau_endpoint": { "query": "AREA[ConditionSearch]\"Alzheimer\" AND AREA[OutcomeSearch]\"tau PET\"", "count": null, "studies": [ { "nct": "NCT07827768", "title": "AV-1959R Vaccine in Individuals With Preclinical Alzheimer's Disease", "status": "NOT_YET_RECRUITING", "last_update": "2026-10-13", "has_results": false }, { "nct": "NCT05183321", "title": "Treatment of Periodontal Disease in Patients With Alzheimer's Disease", "status": "NOT_YET_RECRUITING", "last_update": "2024-05-13", "has_results": false }, { "nct": "NCT04169126", "title": "Topography Staging and Dual Phase Image Quantification of Tau PET in Cognitive Impairment Subjects", "status": "UNKNOWN", "last_update": "2021-01-27", "has_results": false }, { "nct": "NCT05063539", "title": "A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease", "status": "COMPLETED", "last_update": "2026-06-12", "has_results": true }, { "nct": "NCT07347574", "title": "NeuroCare Community Project: A Community Based Prospective Observational Study for Early Alzheimer's Detection in HK", "status": "RECRUITING", "last_update": "2026-07-08", "has_results": false }, { "nct": "NCT07169578", "title": "A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-09-25", "has_results": false }, { "nct": "NCT02791191", "title": "A Study of LY3202626 on Disease Progression in Participants With Mild Alzheimer's Disease Dementia", "status": "TERMINATED", "last_update": "2021-04-19", "has_results": true }, { "nct": "NCT05256134", "title": "A Study to Evaluate the Efficacy and Safety of Gantenerumab in Participants at Risk for or at the Earliest Stages of Alzheimer's Disease (AD)", "status": "TERMINATED", "last_update": "2025-06-12", "has_results": true }, { "nct": "NCT04413344", "title": "Repurposing Bromocriptine for Abeta Metabolism in Alzheimer's Disease", "status": "COMPLETED", "last_update": "2025-08-29", "has_results": false }, { "nct": "NCT05026177", "title": "Simufilam 50 mg or 100 mg for Mild-to-Moderate Alzheimer's Disease", "status": "TERMINATED", "last_update": "2025-09-22", "has_results": true }, { "nct": "NCT06618872", "title": "Incremental Diagnostic Value of Tau-PET With [18F]RO948 vs Amyloid-PET in Patients With Cognitive Impairment", "status": "RECRUITING", "last_update": "2025-12-23", "has_results": false }, { "nct": "NCT05143528", "title": "Evaluating the Efficacy and Safety of Nilotinib BE in Subjects With Early Alzheimer's Disease", "status": "UNKNOWN", "last_update": "2021-12-03", "has_results": false }, { "nct": "NCT05094271", "title": "Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?", "status": "COMPLETED", "last_update": "2026-05-11", "has_results": true }, { "nct": "NCT06679296", "title": "Study on Aging and Cognitive Impairment in China", "status": "RECRUITING", "last_update": "2024-11-07", "has_results": false }, { "nct": "NCT05361382", "title": "Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-09-08", "has_results": false }, { "nct": "NCT05658913", "title": "Tau PET/CT Imaging in the Mismatch Prospective Cohort Study (MPC-TAU)", "status": "RECRUITING", "last_update": "2026-09-04", "has_results": false }, { "nct": "NCT04994847", "title": "APOE in the Predisposition to, Protection From, and Prevention of Alzheimer's Disease", "status": "ENROLLING_BY_INVITATION", "last_update": "2025-07-20", "has_results": false }, { "nct": "NCT02646982", "title": "Candesartan's Effects on Alzheimer's Disease And Related Biomarkers", "status": "COMPLETED", "last_update": "2022-12-01", "has_results": true }, { "nct": "NCT07170150", "title": "A Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-09-25", "has_results": false }, { "nct": "NCT04871074", "title": "The Synapse Project", "status": "COMPLETED", "last_update": "2026-06-26", "has_results": true } ] }, "ctgov_personalized_cognitive": { "query": "AREA[ConditionSearch]\"Alzheimer\" AND AREA[OutcomeSearch]\"personalized\" cognitive", "count": null, "studies": [ { "nct": "NCT04082611", "title": "The PREVENTION Trial: Precision Recommendations to Optimize Neurocognition", "status": "COMPLETED", "last_update": "2025-05-15", "has_results": false }, { "nct": "NCT07146412", "title": "Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study", "status": "ACTIVE_NOT_RECRUITING", "last_update": "2026-09-29", "has_results": false }, { "nct": "NCT06039267", "title": "Brain Health & the Microbiome", "status": "COMPLETED", "last_update": "2026-01-29", "has_results": false }, { "nct": "NCT06403345", "title": "A Feasiblity Study of Green Activity Program for People Living With Memory Challenges", "status": "RECRUITING", "last_update": "2026-07-15", "has_results": false }, { "nct": "NCT07306065", "title": "University of 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